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VTDPRYDASETVAVATTAAPSVARSPRVGYVPTRTNRVRDGVAVVLLVLALLLPWNLQFGVGVPGSDGST FVVLAVVTVLALAAALAPHVGPLRLAAPKADVRRTGVVRLLLCVAYLVVVIGFVAFHLVQTVRNGGTGAV PPGVGPGLLLGAAGALLAAQPPITSITIEDNKFRRWYTVTQAIGFLSIALATLSVAFNLYWRLRYLFVTE VAFGSHDVAVIVTTVLYGAEAMTALVIASRWLTEKTAAARLATTAVGVSGAVAATLVWLMGIGRDIDAFH GIAENTSTAAVGYEGYLAWAVGAAIVAPTTLYAVFLIKPPTLGAYRGAALKCLTLIAFWGFAAAALRIVD YAVAESLNLPRALYDSVAMTVFSLLTAIIARWVHRQISKGVVSTVVTAAFSAVLFVFTVADVAIGVALAP RYAAPAPDAIYGNNLAQQITSTFDIVVCVLSLLVLAVLLFTGPLAGYLSRRQTAKPAPAPAAQVTPAPVT PAVPVDDSAPPTLARRPQPAAVPKIVRLKEDSTTVLPAPPTTELQVPTTTLRIQRRPSSGFTPRPPDNNR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1189 | - | - | 100% (560) | hypothetical protein MSMEG_1189 |
| M. smegmatis MC2 155 | MSMEG_5167 | - | 7e-05 | 26.40% (303) | major facilitator superfamily protein MFS_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0551c | - | 4e-96 | 43.61% (454) | integral membrane protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0537c | - | 5e-96 | 43.61% (454) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0883 | - | 9e-99 | 39.88% (519) | hypothetical protein MMAR_0883 |
| M. avium 104 | MAV_4608 | - | 1e-105 | 42.68% (553) | hypothetical protein MAV_4608 |
| M. thermoresistible (build 8) | TH_4600 | - | 3e-46 | 37.46% (283) | PUTATIVE putative hypothetical protein Mjls_0809 |
| M. ulcerans Agy99 | MUL_0636 | - | 7e-99 | 39.88% (519) | hypothetical protein MUL_0636 |
| M. vanbaalenii PYR-1 | Mvan_1015 | - | 1e-05 | 27.52% (149) | hypothetical protein Mvan_1015 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0551c|M.bovis_AF2122/97 --------------------MG----LSSDD----------TRRREVVRD
Rv0537c|M.tuberculosis_H37Rv --------------------MG----LSSDD----------TRRREVVRD
MMAR_0883|M.marinum_M -MSLGSDDTPTGPIAGAQPQQGQSGQLTLDL----------AHRRNMVRD
MUL_0636|M.ulcerans_Agy99 ----------------MQPQQGQSGQLTLDL----------AHRRNMVRD
MAV_4608|M.avium_104 MVSQSSDDTPTGPIAGQPRQPAAPRIIRSHATGATPPPGPATTGRRVAAD
TH_4600|M.thermoresistible__bu --------------------------------------------------
MSMEG_1189|M.smegmatis_MC2_155 -MTDPRYDASETVAVATTAAPSVARSPRVG---------YVPTRTNRVRD
Mvan_1015|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0551c|M.bovis_AF2122/97 LAAGALLIGALFFPWNLYFGFRIPDSSKTVFGLLLAVTSLSLASLAVTFA
Rv0537c|M.tuberculosis_H37Rv LAAGALLIGALFFPWNLYFGFRIPDSSKTVFGLLLAVTSLSLASLAVTFA
MMAR_0883|M.marinum_M LTGGALLVLAVFFPWNLYFGFRIPGSSNYVLAVLLAVTLLSLIAIAVPYV
MUL_0636|M.ulcerans_Agy99 LTGGALLVLAVFFPWNLYFGFRIPGSSNYVLAVLLAVTLLSLIAIAVPYV
MAV_4608|M.avium_104 LTAVALLLAAVLLPWNLYFGVGIPDSNPIVFAVLVAVTALALAALAV--A
TH_4600|M.thermoresistible__bu --------------------------------------------------
MSMEG_1189|M.smegmatis_MC2_155 GVAVVLLVLALLLPWNLQFGVGVPGSDGSTFVVLAVVTVLALAAALAPHV
Mvan_1015|M.vanbaalenii_PYR-1 -------MTASSIRWVLVDGATGEESVTIDRGSVPVDDAFQADALLDRLL
Mb0551c|M.bovis_AF2122/97 G--RRS----------QLRLGLNVPYLLLVLAFVVFDAIQTIRLGGTVHV
Rv0537c|M.tuberculosis_H37Rv G--RRS----------QLRLGLNVPYLLLVLAFVVFDAIQTIRLGGTVHV
MMAR_0883|M.marinum_M GPWRLSGTRFAPTATNRLRLGLNIPYLLLLLAFVVYDIFQTIRSGGTVNV
MUL_0636|M.ulcerans_Agy99 GPWRLSGTRFAPTATNRLRLGLNIPYLLLLLAFVVYDIFQTIRSGGTVNV
MAV_4608|M.avium_104 GSWRAGGARFDPARAARLRLALNVPYLLLVLAFVGFDAVQTVRFGGTVDV
TH_4600|M.thermoresistible__bu --------------------------------------------------
MSMEG_1189|M.smegmatis_MC2_155 GPLRLAAPKADVRRTGVVRLLLCVAYLVVVIGFVAFHLVQTVRNGGTGAV
Mvan_1015|M.vanbaalenii_PYR-1 G-----------------------------------RPVHAIGLTWTVEA
Mb0551c|M.bovis_AF2122/97 PGGVGPGGWLGITGALLSAQPALTGATTD-------EGSHSRWLRATQFL
Rv0537c|M.tuberculosis_H37Rv PGGVGPGGWLGITGALLSAQPALTGATTD-------EGSHSRWLRATQFL
MMAR_0883|M.marinum_M PGGVGPGGWLGIAGAMLCAQPVSTGQPGD-------NENYDNWLFTARIL
MUL_0636|M.ulcerans_Agy99 PGGVGPGGWLGIAGAMLCAQPVSTGQPGD-------NENYDNWLFTARIL
MAV_4608|M.avium_104 PGGVGPGAWVGIAGALLSAQAVPAGTAAAPVPGTPAGDEATGWHRAARII
TH_4600|M.thermoresistible__bu --------------------------------------------------
MSMEG_1189|M.smegmatis_MC2_155 PPGVGPGLLLGAAGALLAAQPPITSITIE-------DNKFRRWYTVTQAI
Mvan_1015|M.vanbaalenii_PYR-1 ER-TASAVWQGLTDRGVENVIAVSDVESA---------------------
Mb0551c|M.bovis_AF2122/97 GYASMLGAALSTGFNLSWRVRYALEPAAGASGFGKQNLAVIDTAVVYGVV
Rv0537c|M.tuberculosis_H37Rv GYASMLGAALSTGFNLSWRVRYALEPAAGASGFGKQNLAVIDTAVVYGVV
MMAR_0883|M.marinum_M GYASMFGAALSSGFNLAWRVRYALQPTNSASGFGRQNIAVIDTALVYGVV
MUL_0636|M.ulcerans_Agy99 GYASMFGAALSSGFNLAWRVRYALQPTNSASGFGRQNIAVIDTALVYGVV
MAV_4608|M.avium_104 GALSMLAAVLSFGFNLYWRVRYALQSSGGAAQFGKENIAVIATAVVYGVV
TH_4600|M.thermoresistible__bu ------------------------------------------------VV
MSMEG_1189|M.smegmatis_MC2_155 GFLSIALATLSVAFNLYWRLRYLFVT---EVAFGSHDVAVIVTTVLYGAE
Mvan_1015|M.vanbaalenii_PYR-1 ----------------------------EALACGIADLAGCERVVVG--L
Mb0551c|M.bovis_AF2122/97 ALAAVLVASRWLLRPTAAEALSTVALGGSTLIAGSIVWSLPIGREIDAFH
Rv0537c|M.tuberculosis_H37Rv ALAAVLVASRWLLRPTAAEALSTVALGGSTLIAGSIVWSLPIGREIDAFH
MMAR_0883|M.marinum_M ALVAVLVASRWLLKGTREYQLPTIALGASAMVAGIIVWVLPVGREIDAFH
MUL_0636|M.ulcerans_Agy99 ALVAVLVASRWLLKGTREYQLPTIALGASAMVAGIIVWVLPVGREIDAFH
MAV_4608|M.avium_104 ALVAVLVASRWLLRSDRASRLTTIALGTSTLAAGILVWLLPAGRDLDAFH
TH_4600|M.thermoresistible__bu AVIPLVIGYRWLRSTRLAARVATLLLAVSALVAGMIVWVLPVGREVDAFH
MSMEG_1189|M.smegmatis_MC2_155 AMTALVIASRWLTEKTAAARLATTAVGVSGAVAATLVWLMGIGRDIDAFH
Mvan_1015|M.vanbaalenii_PYR-1 AEPGTSVIAAVTPDGVTADRVDPAALTDVDGFDPDAIFVLGSGDVAGVVS
* : : . : :: : * ...
Mb0551c|M.bovis_AF2122/97 GIAQNTSTAGVG-YEGYLVWAAAAAMCAPLTLFRSPNAPPIDKTVWRAAS
Rv0537c|M.tuberculosis_H37Rv GIAQNTSTAGVG-YEGYLVWAAAAAMCAPLTLFRSPNAPPIDKTVWRAAS
MMAR_0883|M.marinum_M GIAQNTSTAGVG-YEGYLVWAAGAAIFAPMALVRS-HTHPIGRDIWRAAA
MUL_0636|M.ulcerans_Agy99 GIAQNTSTAGVG-YEGYLVWATGAAIFAPMALVRS-HTHPIGRDIWRAAA
MAV_4608|M.avium_104 GIAQNTSTAGVG-FEGYLAWAAGAALFAPRTLFERRTPSHTEESAWRATA
TH_4600|M.thermoresistible__bu GIAQNTGISGVG-YEGYLSWVAVAAIVA----VPTVSALRDDRAVWRRAV
MSMEG_1189|M.smegmatis_MC2_155 GIAENTSTAAVG-YEGYLAWAVGAAIVAPTTLYAVFLIKPPTLGAYRGAA
Mvan_1015|M.vanbaalenii_PYR-1 ALEQRSTVPVVSADEADLALARGAALAS----ASAVSILDAQAAPARRRL
.: :.: . *. *. * . **: : *
Mb0551c|M.bovis_AF2122/97 RNGLLLIAVWCLGSVAMRLTDLVVAVLLNYPFSRYDSMALAAFDLATAVL
Rv0537c|M.tuberculosis_H37Rv RNGLLLIAVWCLGSVAMRLTDLVVAVLLNYPFSRYDSMALAAFDLATAVL
MMAR_0883|M.marinum_M RNGLLLIAVWCLGSVVMRLTDLSTAVMLNFPYSRYDTMTLAAFDLVTAAL
MUL_0636|M.ulcerans_Agy99 RNELLLIAVWCLGSVVMRLTDLSTAVMLNFPYSRYDTMTLAAFDLVTAAL
MAV_4608|M.avium_104 RNGLLLIAVWALGSMAMRITDLAVAVTLNYPFSRYDSLVLAAFDLVTAVL
TH_4600|M.thermoresistible__bu RRCLLLIGAWCAGTAVLRLADVALSAVLDLPAPPYNGTALMAFDLLAAVL
MSMEG_1189|M.smegmatis_MC2_155 LKCLTLIAFWGFAAAALRIVDYAVAESLNLPRALYDSVAMTVFSLLTAII
Mvan_1015|M.vanbaalenii_PYR-1 SPTATLASVLATAVVTFVVSLSVALGMTLTPDSPAPQMARAVTEPTPEPV
* . . .: : * . . . . . :
Mb0551c|M.bovis_AF2122/97 AIWLRFNMATEALPARLISSLCGLLCTFTVSRVIVGVVLAPRFQASSGG-
Rv0537c|M.tuberculosis_H37Rv AIWLRFNMATEALPARLISSLCGLLCTFTVSRVIVGVVLAPRFQASSGG-
MMAR_0883|M.marinum_M AFWLRINLVNQALPARLISSLCGFLLTLTVSRVIVGVVLAPRFAASPDA-
MUL_0636|M.ulcerans_Agy99 AFWLRINLVNQALPARLISSLCGFLLTLTVSRVIVGVVLAPRFAASPDA-
MAV_4608|M.avium_104 AIWLRRQLAN--LAARLVTSLCGLVAALAVARVVVGVQLAPRFADTPNSP
TH_4600|M.thermoresistible__bu AWWLFLNAGR-FAPGRMLTTLFAVLFAAVVSRVIVGIALVPRSEPLDPA-
MSMEG_1189|M.smegmatis_MC2_155 ARWVHRQISKGVVSTVVTAAFSAVLFVFTVADVAIGVALAPRYAAPAPD-
Mvan_1015|M.vanbaalenii_PYR-1 EKPVVKPAPVKAAPPEPEAAPPPPAAPPVAEPVAVEIPAPAAPALPEAP-
: . :: .. * : : .
Mb0551c|M.bovis_AF2122/97 SAHPVYGNDLAQQITSTFDVVLCGLALSILAAAIVIG-------------
Rv0537c|M.tuberculosis_H37Rv SAHPVYGNDLAQQITSTFDVVLCGLALSILAAAIVIG-------------
MMAR_0883|M.marinum_M RPNPVYGNNLAQQITSTFDVTLCGLALGIVVAVIISGRRSATQTKRPGRP
MUL_0636|M.ulcerans_Agy99 RPNPVYGNNLAQQITSTFDVTLCGLALGIVVAVIISGRRSATQTKQPGRP
MAV_4608|M.avium_104 VHHPVYGNNLAQQITSVFDVTLCGLALGILVAAVVAG----QLGRRRRAR
TH_4600|M.thermoresistible__bu TINAVFGNTLVQQITSTFDVTLVVLALALSVIAIMTAR------------
MSMEG_1189|M.smegmatis_MC2_155 ---AIYGNNLAQQITSTFDIVVCVLSLLVLAVLLFTG---------PLAG
Mvan_1015|M.vanbaalenii_PYR-1 --PPVYDEPLAPPPVVAPAPAYVPPPPPANYLPPAPAAP-----------
.::.: *. . . . . .
Mb0551c|M.bovis_AF2122/97 --RLRQLPQP-----------------------------------PHTPA
Rv0537c|M.tuberculosis_H37Rv --RLRQLPQP-----------------------------------PHTPA
MMAR_0883|M.marinum_M RRRQRRTGQPGPARGGAAVPSEA------ETTQFRSPAALDAHDDAPTTV
MUL_0636|M.ulcerans_Agy99 RRRQRRTGQPGPARGGAAVPSEA------ETTQFRSPAALDAHDDAPTTV
MAV_4608|M.avium_104 RAARRRAAQANAAAPTTRIPVSQGAAPSAAATTRIATGGPGADHEPPTTE
TH_4600|M.thermoresistible__bu -PARPTASKPAGPAG------------------------------PAERR
MSMEG_1189|M.smegmatis_MC2_155 YLSRRQTAKPAPAPAAQVTPAPVTP-----------AVPVDDSAPPTLAR
Mvan_1015|M.vanbaalenii_PYR-1 -AYVPPAQVP--------------------------------AYVPPAQQ
. .
Mb0551c|M.bovis_AF2122/97 LSRPAGSPRIFR---SAGSTHPVR--------------------PKIYRP
Rv0537c|M.tuberculosis_H37Rv LSRPAGSPRIFR---SAGSTHPVR--------------------PKIYRP
MMAR_0883|M.marinum_M LSGPGRAPRIFR---SGESTGPLP--------------------PKIYRR
MUL_0636|M.ulcerans_Agy99 LSGPGRAPRIFR---SGESTGPLP--------------------PKIYRR
MAV_4608|M.avium_104 IPPLAGSPRIFRGDDSGTRQIPVPK-------------------PQIYRP
TH_4600|M.thermoresistible__bu AAAPRKSASAWPTIVIPTRSGPAR----------------------IVRP
MSMEG_1189|M.smegmatis_MC2_155 RPQPAAVPKIVRLKEDSTTVLPAPPTTELQVPTTTLRIQRRPSSGFTPRP
Mvan_1015|M.vanbaalenii_PYR-1 PAYVPPAPQQPRLRDRIIERIPIIN---------------------RFHE
. . * :
Mb0551c|M.bovis_AF2122/97 PDHSS
Rv0537c|M.tuberculosis_H37Rv PDHSS
MMAR_0883|M.marinum_M PDDPS
MUL_0636|M.ulcerans_Agy99 LDDPS
MAV_4608|M.avium_104 PQQ--
TH_4600|M.thermoresistible__bu GHDDD
MSMEG_1189|M.smegmatis_MC2_155 PDNNR
Mvan_1015|M.vanbaalenii_PYR-1 PEY--
.