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GLSSDDTRRREVVRDLAAGALLIGALFFPWNLYFGFRIPDSSKTVFGLLLAVTSLSLASLAVTFAGRRSQ LRLGLNVPYLLLVLAFVVFDAIQTIRLGGTVHVPGGVGPGGWLGITGALLSAQPALTGATTDEGSHSRWL RATQFLGYASMLGAALSTGFNLSWRVRYALEPAAGASGFGKQNLAVIDTAVVYGVVALAAVLVASRWLLR PTAAEALSTVALGGSTLIAGSIVWSLPIGREIDAFHGIAQNTSTAGVGYEGYLVWAAAAAMCAPLTLFRS PNAPPIDKTVWRAASRNGLLLIAVWCLGSVAMRLTDLVVAVLLNYPFSRYDSMALAAFDLATAVLAIWLR FNMATEALPARLISSLCGLLCTFTVSRVIVGVVLAPRFQASSGGSAHPVYGNDLAQQITSTFDVVLCGLA LSILAAAIVIGRLRQLPQPPHTPALSRPAGSPRIFRSAGSTHPVRPKIYRPPDHSS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0537c | - | - | 100% (477) | PROBABLE INTEGRAL MEMBRANE PROTEIN |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0551c | - | 0.0 | 100.00% (477) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_3578 | - | 9e-05 | 24.59% (305) | hypothetical protein Mflv_3578 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0883 | - | 1e-174 | 61.21% (531) | hypothetical protein MMAR_0883 |
| M. avium 104 | MAV_4608 | - | 1e-149 | 56.18% (534) | hypothetical protein MAV_4608 |
| M. smegmatis MC2 155 | MSMEG_1189 | - | 6e-96 | 43.61% (454) | hypothetical protein MSMEG_1189 |
| M. thermoresistible (build 8) | TH_4600 | - | 6e-56 | 46.48% (256) | PUTATIVE putative hypothetical protein Mjls_0809 |
| M. ulcerans Agy99 | MUL_0636 | - | 1e-172 | 60.64% (531) | hypothetical protein MUL_0636 |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0537c|M.tuberculosis_H37Rv --------------------MG----LSSDD----------TRRREVVRD
Mb0551c|M.bovis_AF2122/97 --------------------MG----LSSDD----------TRRREVVRD
MMAR_0883|M.marinum_M -MSLGSDDTPTGPIAGAQPQQGQSGQLTLDL----------AHRRNMVRD
MUL_0636|M.ulcerans_Agy99 ----------------MQPQQGQSGQLTLDL----------AHRRNMVRD
MAV_4608|M.avium_104 MVSQSSDDTPTGPIAGQPRQPAAPRIIRSHATGATPPPGPATTGRRVAAD
MSMEG_1189|M.smegmatis_MC2_155 -MTDPRYDASETVAVATTAAPSVARSPRVGY---------VPTRTNRVRD
TH_4600|M.thermoresistible__bu --------------------------------------------------
Mflv_3578|M.gilvum_PYR-GCK -MADMTEPHSAVIARLSADFAAISHQLTRVSG-------DLAALDRILTD
Rv0537c|M.tuberculosis_H37Rv LAAGALLIGALFFPWNLYFGFRIPDSSKTVFGLLLAVTSLSLASLAVTFA
Mb0551c|M.bovis_AF2122/97 LAAGALLIGALFFPWNLYFGFRIPDSSKTVFGLLLAVTSLSLASLAVTFA
MMAR_0883|M.marinum_M LTGGALLVLAVFFPWNLYFGFRIPGSSNYVLAVLLAVTLLSLIAIAVPYV
MUL_0636|M.ulcerans_Agy99 LTGGALLVLAVFFPWNLYFGFRIPGSSNYVLAVLLAVTLLSLIAIAVPYV
MAV_4608|M.avium_104 LTAVALLLAAVLLPWNLYFGVGIPDSNPIVFAVLVAVTALALAALAV--A
MSMEG_1189|M.smegmatis_MC2_155 GVAVVLLVLALLLPWNLQFGVGVPGSDGSTFVVLAVVTVLALAAALAPHV
TH_4600|M.thermoresistible__bu --------------------------------------------------
Mflv_3578|M.gilvum_PYR-GCK RAPAAAAPRPAPQPAAYWPQYPPQPAPFRPWPQAPAPAPTQALTPAPRKE
Rv0537c|M.tuberculosis_H37Rv G--RRS----------QLRLGLNVPYLLLVLAFVVFDAIQTIRLGGTVHV
Mb0551c|M.bovis_AF2122/97 G--RRS----------QLRLGLNVPYLLLVLAFVVFDAIQTIRLGGTVHV
MMAR_0883|M.marinum_M GPWRLSGTRFAPTATNRLRLGLNIPYLLLLLAFVVYDIFQTIRSGGTVNV
MUL_0636|M.ulcerans_Agy99 GPWRLSGTRFAPTATNRLRLGLNIPYLLLLLAFVVYDIFQTIRSGGTVNV
MAV_4608|M.avium_104 GSWRAGGARFDPARAARLRLALNVPYLLLVLAFVGFDAVQTVRFGGTVDV
MSMEG_1189|M.smegmatis_MC2_155 GPLRLAAPKADVRRTGVVRLLLCVAYLVVVIGFVAFHLVQTVRNGGTGAV
TH_4600|M.thermoresistible__bu --------------------------------------------------
Mflv_3578|M.gilvum_PYR-GCK RSEGWIGKLLAVAGVAVTLIGVVLLLVLAAQAGILRPEFRVSAGGALAAA
Rv0537c|M.tuberculosis_H37Rv PGGVGPGGWLGITGALLSAQPALTGATTD-------EGSHSRWLRATQFL
Mb0551c|M.bovis_AF2122/97 PGGVGPGGWLGITGALLSAQPALTGATTD-------EGSHSRWLRATQFL
MMAR_0883|M.marinum_M PGGVGPGGWLGIAGAMLCAQPVSTGQPGD-------NENYDNWLFTARIL
MUL_0636|M.ulcerans_Agy99 PGGVGPGGWLGIAGAMLCAQPVSTGQPGD-------NENYDNWLFTARIL
MAV_4608|M.avium_104 PGGVGPGAWVGIAGALLSAQAVPAGTAAAPVPGTPAGDEATGWHRAARII
MSMEG_1189|M.smegmatis_MC2_155 PPGVGPGLLLGAAGALLAAQPPITSITIE-------DNKFRRWYTVTQAI
TH_4600|M.thermoresistible__bu --------------------------------------------------
Mflv_3578|M.gilvum_PYR-GCK LVGAGWWLNTRPGGRVGAIALVATGVAAAYMDVIAVTTIYDWVPAPAGLV
Rv0537c|M.tuberculosis_H37Rv GYASMLGAALSTG--FNLSWRVRYALEPAAGASGFGKQNLAVIDTAVVYG
Mb0551c|M.bovis_AF2122/97 GYASMLGAALSTG--FNLSWRVRYALEPAAGASGFGKQNLAVIDTAVVYG
MMAR_0883|M.marinum_M GYASMFGAALSSG--FNLAWRVRYALQPTNSASGFGRQNIAVIDTALVYG
MUL_0636|M.ulcerans_Agy99 GYASMFGAALSSG--FNLAWRVRYALQPTNSASGFGRQNIAVIDTALVYG
MAV_4608|M.avium_104 GALSMLAAVLSFG--FNLYWRVRYALQSSGGAAQFGKENIAVIATAVVYG
MSMEG_1189|M.smegmatis_MC2_155 GFLSIALATLSVA--FNLYWRLRYLFVT---EVAFGSHDVAVIVTTVLYG
TH_4600|M.thermoresistible__bu --------------------------------------------------
Mflv_3578|M.gilvum_PYR-GCK LAAVIAGAGLTLARRWDSEHLGLLVLVPLIVLAPIVTDGVSLLLVGFMLA
Rv0537c|M.tuberculosis_H37Rv VVALAAVLVASR---WLLRPTAAEALS--TVALGGSTLIAGSIVWSLPIG
Mb0551c|M.bovis_AF2122/97 VVALAAVLVASR---WLLRPTAAEALS--TVALGGSTLIAGSIVWSLPIG
MMAR_0883|M.marinum_M VVALVAVLVASR---WLLKGTREYQLP--TIALGASAMVAGIIVWVLPVG
MUL_0636|M.ulcerans_Agy99 VVALVAVLVASR---WLLKGTREYQLP--TIALGASAMVAGIIVWVLPVG
MAV_4608|M.avium_104 VVALVAVLVASR---WLLRSDRASRLT--TIALGTSTLAAGILVWLLPAG
MSMEG_1189|M.smegmatis_MC2_155 AEAMTALVIASR---WLTEKTAAARLA--TTAVGVSGAVAATLVWLMGIG
TH_4600|M.thermoresistible__bu VVAVIPLVIGYR---WLRSTRLAARVA--TLLLAVSALVAGMIVWVLPVG
Mflv_3578|M.gilvum_PYR-GCK LAAVSLPVQLGKDWIWLHAARIAAAVLPLLVALAARHIDSREDLWLAGAC
*: : : ** : :. : :*
Rv0537c|M.tuberculosis_H37Rv REIDAFHGIAQNTSTAGVGYEGYLVWAAAAAMCAPLTL-FRSPNAPPIDK
Mb0551c|M.bovis_AF2122/97 REIDAFHGIAQNTSTAGVGYEGYLVWAAAAAMCAPLTL-FRSPNAPPIDK
MMAR_0883|M.marinum_M REIDAFHGIAQNTSTAGVGYEGYLVWAAGAAIFAPMAL-VRS-HTHPIGR
MUL_0636|M.ulcerans_Agy99 REIDAFHGIAQNTSTAGVGYEGYLVWATGAAIFAPMAL-VRS-HTHPIGR
MAV_4608|M.avium_104 RDLDAFHGIAQNTSTAGVGFEGYLAWAAGAALFAPRTL-FERRTPSHTEE
MSMEG_1189|M.smegmatis_MC2_155 RDIDAFHGIAENTSTAAVGYEGYLAWAVGAAIVAPTTL-YAVFLIKPPTL
TH_4600|M.thermoresistible__bu REVDAFHGIAQNTGISGVGYEGYLSWVAVAAIVAVPTV-SAL----RDDR
Mflv_3578|M.gilvum_PYR-GCK GIAAVIALTAALILLPGTGNRVVMALLTVAGIVPVLCVNLAVDRVVAALM
.: * ...* . : . *.: . :
Rv0537c|M.tuberculosis_H37Rv TVWRAASRNGLLLIAVWCLGSVAMRLTDLVVAVLLNYPFSRYDSMALAAF
Mb0551c|M.bovis_AF2122/97 TVWRAASRNGLLLIAVWCLGSVAMRLTDLVVAVLLNYPFSRYDSMALAAF
MMAR_0883|M.marinum_M DIWRAAARNGLLLIAVWCLGSVVMRLTDLSTAVMLNFPYSRYDTMTLAAF
MUL_0636|M.ulcerans_Agy99 DIWRAAARNELLLIAVWCLGSVVMRLTDLSTAVMLNFPYSRYDTMTLAAF
MAV_4608|M.avium_104 SAWRATARNGLLLIAVWALGSMAMRITDLAVAVTLNYPFSRYDSLVLAAF
MSMEG_1189|M.smegmatis_MC2_155 GAYRGAALKCLTLIAFWGFAAAALRIVDYAVAESLNLPRALYDSVAMTVF
TH_4600|M.thermoresistible__bu AVWRRAVRRCLLLIGAWCAGTAVLRLADVALSAVLDLPAPPYNGTALMAF
Mflv_3578|M.gilvum_PYR-GCK AAALAAALLAVALLADRLPGVDGVVRRVFAVTSAIAALIAVTTAFDGRVG
: : *:. . : : : . .
Rv0537c|M.tuberculosis_H37Rv DLATAVLAIWLRFNMATEALPARLISSLCGLLCTFTVSRVIVGVVLAPRF
Mb0551c|M.bovis_AF2122/97 DLATAVLAIWLRFNMATEALPARLISSLCGLLCTFTVSRVIVGVVLAPRF
MMAR_0883|M.marinum_M DLVTAALAFWLRINLVNQALPARLISSLCGFLLTLTVSRVIVGVVLAPRF
MUL_0636|M.ulcerans_Agy99 DLVTAALAFWLRINLVNQALPARLISSLCGFLLTLTVSRVIVGVVLAPRF
MAV_4608|M.avium_104 DLVTAVLAIWLRRQLAN--LAARLVTSLCGLVAALAVARVVVGVQLAPRF
MSMEG_1189|M.smegmatis_MC2_155 SLLTAIIARWVHRQISKGVVSTVVTAAFSAVLFVFTVADVAIGVALAPRY
TH_4600|M.thermoresistible__bu DLLAAVLAWWLFLNAGR-FAPGRMLTTLFAVLFAAVVSRVIVGIALVPRS
Mflv_3578|M.gilvum_PYR-GCK GPVLLAMAVVVAIAVGRDVVGRWVAIGFAVIGAAAHLSYAPLAVLLQPVE
. :* : : : . . :: . :.: * *
Rv0537c|M.tuberculosis_H37Rv QASSGG---SAHPVYGNDLAQQITSTFDVVLCGLALSILAAAIVIG----
Mb0551c|M.bovis_AF2122/97 QASSGG---SAHPVYGNDLAQQITSTFDVVLCGLALSILAAAIVIG----
MMAR_0883|M.marinum_M AASPDA---RPNPVYGNNLAQQITSTFDVTLCGLALGIVVAVIISGRRSA
MUL_0636|M.ulcerans_Agy99 AASPDA---RPNPVYGNNLAQQITSTFDVTLCGLALGIVVAVIISGRRSA
MAV_4608|M.avium_104 ADTPNSP--VHHPVYGNNLAQQITSVFDVTLCGLALGILVAAVVAG----
MSMEG_1189|M.smegmatis_MC2_155 AAPAPD------AIYGNNLAQQITSTFDIVVCVLSLLVLAVLLFTG----
TH_4600|M.thermoresistible__bu EPLDPA---TINAVFGNTLVQQITSTFDVTLVVLALALSVIAIMTAR---
Mflv_3578|M.gilvum_PYR-GCK VSTATGISTLVSSLLLATAAVTIVWMWDRTETALWVGAAVVTVYAVTS--
.: . *. :* . * : . :
Rv0537c|M.tuberculosis_H37Rv -----------RLRQLPQP-------------------------------
Mb0551c|M.bovis_AF2122/97 -----------RLRQLPQP-------------------------------
MMAR_0883|M.marinum_M TQTKRPGRPRRRQRRTGQPGPARGGAAVPSEA------ETTQFRSPAALD
MUL_0636|M.ulcerans_Agy99 TQTKQPGRPRRRQRRTGQPGPARGGAAVPSEA------ETTQFRSPAALD
MAV_4608|M.avium_104 QLGRRRRARRAARRRAAQANAAAPTTRIPVSQGAAPSAAATTRIATGGPG
MSMEG_1189|M.smegmatis_MC2_155 -----PLAGYLSRRQTAKPAPAPAAQVTPAP------------VTPAVPV
TH_4600|M.thermoresistible__bu ----------PARPTASKPAG-----------------------------
Mflv_3578|M.gilvum_PYR-GCK ------CTVTAGMLVIGGDGGFYAGHMVATILWIAMAAVLFWYAARLPRE
Rv0537c|M.tuberculosis_H37Rv ----PHTPALSR-PAGSPRIFR---------SAGSTHPVR----------
Mb0551c|M.bovis_AF2122/97 ----PHTPALSR-PAGSPRIFR---------SAGSTHPVR----------
MMAR_0883|M.marinum_M AHDDAPTTVLSG-PGRAPRIFR---------SGESTGPLP----------
MUL_0636|M.ulcerans_Agy99 AHDDAPTTVLSG-PGRAPRIFR---------SGESTGPLP----------
MAV_4608|M.avium_104 ADHEPPTTEIPP-LAGSPRIFRGDD------SGTRQIPVPK---------
MSMEG_1189|M.smegmatis_MC2_155 DDSAPPTLARRPQPAAVPKIVRLKE------DSTTVLPAPPTTELQVPTT
TH_4600|M.thermoresistible__bu ----PAGPAERR--AAAPRKSAS-A------WPTIVIPTRSGP-------
Mflv_3578|M.gilvum_PYR-GCK DRSVPLGGGLGLVAAAMAKLFLFDLGTLDGIFRVVVFIVVGLTLLGIGAG
. . .:
Rv0537c|M.tuberculosis_H37Rv -PKIYR---------PPDHSS
Mb0551c|M.bovis_AF2122/97 -PKIYR---------PPDHSS
MMAR_0883|M.marinum_M -PKIYR---------RPDDPS
MUL_0636|M.ulcerans_Agy99 -PKIYR---------RLDDPS
MAV_4608|M.avium_104 -PQIYR---------PPQQ--
MSMEG_1189|M.smegmatis_MC2_155 TLRIQRRPSSGFTPRPPDNNR
TH_4600|M.thermoresistible__bu -ARIVR---------PGHDDD
Mflv_3578|M.gilvum_PYR-GCK YARLLERQDKQAATRTFDTT-
:: . .