For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VRTTGSVPVLALAGYLGAGKTTLLNHLLRNSRGVRIGALVNDFGAVNIDAMLVAGQVDAMAGLTNGCICC AVDADEAGEMLGKLAAVKPRLDLIVVEASGLAEPAALARTIAMADDTRYHYAGLVLVVDAVESTRAELGN NVQVADLVVVNKADQVSDAELEAVRAKITALNDRVPVLPTEFGRVDPELLVDPPQQVPRVAQLSLDELLW ETYDHDHHEHATFQSVAFTSDVPLDPRRFMDLLKNRPAGMYRAKGFVDFGDAGEGRKFVLQLVGGSLRFE RRRWDRGEARRTSLVLIGTDIDEAAALSALQGCATAEPADKQAILGVLRYTD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1123 | - | - | 100% (332) | cobalamin synthesis protein |
| M. smegmatis MC2 155 | MSMEG_6048 | - | 8e-32 | 32.24% (366) | cobalamin synthesis protein/P47K |
| M. smegmatis MC2 155 | MSMEG_4869 | - | 2e-05 | 28.57% (182) | LAO/AO transport system ATPase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1883 | ureG | 5e-06 | 27.51% (189) | urease accessory protein ureG |
| M. gilvum PYR-GCK | Mflv_1052 | - | 1e-29 | 54.03% (124) | cobalamin synthesis protein, P47K |
| M. tuberculosis H37Rv | Rv1852 | ureG | 5e-06 | 27.51% (189) | urease accessory protein ureG |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3425c | - | 2e-67 | 45.87% (303) | putative cobalamin synthesis protein |
| M. marinum M | MMAR_4787 | - | 3e-05 | 27.93% (179) | transport system kinase |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_4457 | - | 1e-53 | 38.81% (335) | PUTATIVE cobalamin synthesis protein, P47K |
| M. ulcerans Agy99 | MUL_0356 | - | 2e-05 | 27.37% (179) | transport system kinase |
| M. vanbaalenii PYR-1 | Mvan_5779 | - | 5e-48 | 39.64% (333) | cobalamin synthesis protein, P47K |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1883|M.bovis_AF2122/97 ---------------------------------MATHSHPHSHTVPARPR
Rv1852|M.tuberculosis_H37Rv ---------------------------------MATHSHPHSHTVPARPR
Mflv_1052|M.gilvum_PYR-GCK MGPDLQIDSGGVASPAVQPIPVIALTGYLGAGKTTLLNHVLR-SPDARIG
Mvan_5779|M.vanbaalenii_PYR-1 ----------------MQPIPVIALTGYLGAGKTTLLNHVLR-SPDARIG
TH_4457|M.thermoresistible__bu ----------------VEPIPVIALTGYLGAGKTSLLNHVLR-TPGARIG
MAB_3425c|M.abscessus_ATCC_199 ------------------MIPVTIVSGFLGAGKTTLLNNLLRNTLGVRIG
MSMEG_1123|M.smegmatis_MC2_155 -------------MRTTGSVPVLALAGYLGAGKTTLLNHLLRNSRGVRIG
MMAR_4787|M.marinum_M -------------------MSIDDLIAAARNGSQRAAGRLLSLIEGDRRD
MUL_0356|M.ulcerans_Agy99 -------------------MSIDDLIAAARNGSQRAAGRLLSLIEGDRRD
.. *
Mb1883|M.bovis_AF2122/97 RVRKPGEPLRIG---VGGPVGSG----KTALVAALCRQLRG---ELSLAV
Rv1852|M.tuberculosis_H37Rv RVRKPGEPLRIG---VGGPVGSG----KTALVAALCRQLRG---ELSLAV
Mflv_1052|M.gilvum_PYR-GCK VVINDFGELNVDAGLVTGQVDEP----ASIAGGCICCLPDEGGLDVALER
Mvan_5779|M.vanbaalenii_PYR-1 VVINDFGELNVDAGLVTGQVDEP----ASIAGGCICCLPDEGGLDSALAR
TH_4457|M.thermoresistible__bu VVINDFGDINVDASMVTGQIDEP----ASIAGGCICCLPDDGELDVALAK
MAB_3425c|M.abscessus_ATCC_199 VVVNDFGAINIDAMLVAGQVDST----MTMSNGCLCCTADDDELGGMLSA
MSMEG_1123|M.smegmatis_MC2_155 ALVNDFGAVNIDAMLVAGQVDAM----AGLTNGCICCAVDADEAGEMLGK
MMAR_4787|M.marinum_M EVLAGIEDWSQRPARVIGITGPPGAGKSTTITGLVGAYRERGTRVAVLAV
MUL_0356|M.ulcerans_Agy99 EVLAGIEDWSQRPARVIGITGPPGAGKSTTITGLVGAYRERGTRVAVLAV
: * * . . : *
Mb1883|M.bovis_AF2122/97 LTN-----DIYTTEDADFLRTHAVLPDDRIAAVQT-----GGCPHTAIRD
Rv1852|M.tuberculosis_H37Rv LTN-----DIYTTEDADFLRTHAVLPDDRIAAVQT-----GGCPHTAIRD
Mflv_1052|M.gilvum_PYR-GCK LADPKLRLDAIIVEASGLADPVAVSRIIRFSGVDG--IRPGGVVDVLDAA
Mvan_5779|M.vanbaalenii_PYR-1 LADPKLRLDAIIVEASGLADPVAVSRIIRFSGVDG--VRPGGVVDVLDAA
TH_4457|M.thermoresistible__bu LADPRLRLDAIIIEASGVAEPASIARMIGFSGVDG--IRDGGVVDVIDAA
MAB_3425c|M.abscessus_ATCC_199 LAG--RDIDAIVIEASGLAEPLPLVRMVLAATAEDRRIGYGGLVTVVDTA
MSMEG_1123|M.smegmatis_MC2_155 LAAVKPRLDLIVVEASGLAEPAALARTIAMADDTR--YHYAGLVLVVDAV
MMAR_4787|M.marinum_M DPSSPFSGGALLGDRIRMTAHVNDSEVLIRSVASRG--HLGGLAASVPAA
MUL_0356|M.ulcerans_Agy99 DPSSPFSGGALLGDRIRMTAHVNDSEVLIRSVASRG--HLGGLAASVPAA
. . : . : .*
Mb1883|M.bovis_AF2122/97 DITANLDAIDELMAAHDALDLILVES------------------------
Rv1852|M.tuberculosis_H37Rv DITANLDAIDELMAAHDALDLILVES------------------------
Mflv_1052|M.gilvum_PYR-GCK THFDTIDRDDAPPARYGPP-------------------------------
Mvan_5779|M.vanbaalenii_PYR-1 THFDTVDRDATPPARYGAATLVVVNKLDRIPVRDRADALVRIESRVRELN
TH_4457|M.thermoresistible__bu NHFDTVDRGDQPPARYGAATLVVVNKLDQIPEQERPALLRRVEDRVRERN
MAB_3425c|M.abscessus_ATCC_199 QYEDVAVRHPEIAQHLDLADLVVLNKIDLADAGDR----THLRAVVKERN
MSMEG_1123|M.smegmatis_MC2_155 ESTR-----AELGNNVQVADLVVVNKADQVSDAEL----EAVRAKITALN
MMAR_4787|M.marinum_M IRLLGALRYDVVLLETVGVGQSEIEVAAVADP----------TVVVLNPG
MUL_0356|M.ulcerans_Agy99 IRLLGALRYDVVLLKTVGVGQSEIEVVAVADP----------TVVVLNPG
Mb1883|M.bovis_AF2122/97 ----------------------------GGDNLTATFSSGLVDAQ-----
Rv1852|M.tuberculosis_H37Rv ----------------------------GGDNLTATFSSGLVDAQ-----
Mflv_1052|M.gilvum_PYR-GCK ----------------------------------PWWSSTSSTGY-----
Mvan_5779|M.vanbaalenii_PYR-1 PHAHVVGATAGRIDPALLYDVAGDAETLGQLTFRELWSDAEAQAHPHVHD
TH_4457|M.thermoresistible__bu PRAHIVGTTGGRIDPALLYDVASAQDETGQLSFRDLFIEPSDHGAHG--D
MAB_3425c|M.abscessus_ATCC_199 PRASIVETTGADVDPRLLFDKKERPEPVGQLSLEDLIREDHSHEH-----
MSMEG_1123|M.smegmatis_MC2_155 DRVPVLPTEFGRVDPELLVDPPQQVPRVAQLSLDELLWETYDHDH-----
MMAR_4787|M.marinum_M TGDAVQAAKAGLLEVADIVAVNKADRVGAEQTVRDLRAETNAPILS----
MUL_0356|M.ulcerans_Agy99 TGDAVQAAKAGLLEVADIVAVNKADRVGAEQTVRDLRAETNAPILS----
.
Mb1883|M.bovis_AF2122/97 --------------------------------------IFVIDVAGGDKV
Rv1852|M.tuberculosis_H37Rv --------------------------------------IFVIDVAGGDKV
Mflv_1052|M.gilvum_PYR-GCK ------------------------------------------RPRSVPRR
Mvan_5779|M.vanbaalenii_PYR-1 HDHSHADSVTVTGEGCVDPAAVIDLLEAPPDGVYRMKGTVAVRYRSSSRC
TH_4457|M.thermoresistible__bu HDHVHADSVTVTSTGTVDPVRLVELLEDPPARVYRLKGTVAVRQRSNPRH
MAB_3425c|M.abscessus_ATCC_199 HAHHHYETVEFATEQPLHPRRLIEFLDSQPAGVYRIKG----LVRLGDRT
MSMEG_1123|M.smegmatis_MC2_155 HEHATFQSVAFTSDVPLDPRRFMDLLKNRPAGMYRAKGFVDFGDAGEGRK
MMAR_4787|M.marinum_M ----------------------------------------LVAVKSEGIG
MUL_0356|M.ulcerans_Agy99 ----------------------------------------LVAVKSEGIG
Mb1883|M.bovis_AF2122/97 PRKGGPGVTYSDLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQSL
Rv1852|M.tuberculosis_H37Rv PRKGGPGVTYSDLLVVNKTDLAALVGADLAVMARDADAVRDGRPTVLQSL
Mflv_1052|M.gilvum_PYR-GCK WSASRAG---SAR-------------------------------------
Mvan_5779|M.vanbaalenii_PYR-1 YSVNVVG---PSVHIAVAPPRAVANSLVAIGMGLDVEAVRERMRSALTPV
TH_4457|M.thermoresistible__bu YLINAVG---SAVHVTTRRSRVSENSLVAIGMGLDIDAVRTRLSTALQPF
MAB_3425c|M.abscessus_ATCC_199 LAVHTVGDHISFDKVGRASDFSSGASLVLIGTHLDGDTITERLRTLIDDP
MSMEG_1123|M.smegmatis_MC2_155 FVLQLVGGSLRFERRRWDRGEARRTSLVLIGTDIDEAAALSALQGCAT--
MMAR_4787|M.marinum_M ELLALIDAHQRGDSRDRRLARARAQILSLAQTRLRGRTDLDRLAEAVVDG
MUL_0356|M.ulcerans_Agy99 ELLALIDAHQRGDSRDRRLARARAQILSLAQTRLRGRTDLDRLAEAVVDG
.
Mb1883|M.bovis_AF2122/97 TEDPAASDVVAWVRSQLAADGV
Rv1852|M.tuberculosis_H37Rv TEDPAASDVVAWVRSQLAADGV
Mflv_1052|M.gilvum_PYR-GCK ----------------------
Mvan_5779|M.vanbaalenii_PYR-1 QGAASAHGLRRLQRYRKLSI--
TH_4457|M.thermoresistible__bu DGPTSAAALRRLQRYQAGVG--
MAB_3425c|M.abscessus_ATCC_199 PDPDRERSMLVLGKYLR-----
MSMEG_1123|M.smegmatis_MC2_155 AEPADKQAILGVLRYTD-----
MMAR_4787|M.marinum_M LEDPYAAADRLLAPPPP-----
MUL_0356|M.ulcerans_Agy99 LEDPYAAADRLLAPPPP-----