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IPVTIVSGFLGAGKTTLLNNLLRNTLGVRIGVVVNDFGAINIDAMLVAGQVDSTMTMSNGCLCCTADDDE LGGMLSALAGRDIDAIVIEASGLAEPLPLVRMVLAATAEDRRIGYGGLVTVVDTAQYEDVAVRHPEIAQH LDLADLVVLNKIDLADAGDRTHLRAVVKERNPRASIVETTGADVDPRLLFDKKERPEPVGQLSLEDLIRE DHSHEHHAHHHYETVEFATEQPLHPRRLIEFLDSQPAGVYRIKGLVRLGDRTLAVHTVGDHISFDKVGRA SDFSSGASLVLIGTHLDGDTITERLRTLIDDPPDPDRERSMLVLGKYLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3425c | - | - | 100% (330) | putative cobalamin synthesis protein |
| M. abscessus ATCC 19977 | MAB_1046c | - | 4e-35 | 29.23% (349) | cobalamin synthesis protein P47K/CobW |
| M. abscessus ATCC 19977 | MAB_0335 | - | 8e-08 | 23.26% (258) | cobalamin synthesis protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0109 | - | 2e-06 | 26.22% (286) | hypothetical protein Mb0109 |
| M. gilvum PYR-GCK | Mflv_1052 | - | 2e-26 | 46.67% (135) | cobalamin synthesis protein, P47K |
| M. tuberculosis H37Rv | Rv0106 | - | 2e-06 | 26.22% (286) | hypothetical protein Rv0106 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0293 | - | 7e-07 | 26.86% (242) | hypothetical protein MMAR_0293 |
| M. avium 104 | MAV_4874 | - | 4e-08 | 26.22% (267) | CobW/P47K domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1123 | - | 2e-67 | 45.87% (303) | cobalamin synthesis protein |
| M. thermoresistible (build 8) | TH_4457 | - | 5e-57 | 42.06% (340) | PUTATIVE cobalamin synthesis protein, P47K |
| M. ulcerans Agy99 | MUL_4830 | - | 5e-07 | 26.86% (242) | hypothetical protein MUL_4830 |
| M. vanbaalenii PYR-1 | Mvan_5779 | - | 6e-51 | 38.27% (324) | cobalamin synthesis protein, P47K |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0109|M.bovis_AF2122/97 -----------------MRTPVILVAGQD--HTDEVTGALLRRTGTVVVE
Rv0106|M.tuberculosis_H37Rv -----------------MRTPVILVAGQD--HTDEVTGALLRRTGTVVVE
MMAR_0293|M.marinum_M -----------------MRTPVVLVAGQG--DTDDVTGLLLRRPGTVVVE
MUL_4830|M.ulcerans_Agy99 -----------------MRTPVVLVAGQG--DTDDVTGLLLRRPGTVVVE
MAV_4874|M.avium_104 ------------------------------------MGALLRTSGTLVVE
MAB_3425c|M.abscessus_ATCC_199 ------------------MIPVTIVSGFLGAGKTTLLNNLLRNTLGVRIG
MSMEG_1123|M.smegmatis_MC2_155 -------------MRTTGSVPVLALAGYLGAGKTTLLNHLLRNSRGVRIG
Mflv_1052|M.gilvum_PYR-GCK MGPDLQIDSGGVASPAVQPIPVIALTGYLGAGKTTLLNHVLR-SPDARIG
Mvan_5779|M.vanbaalenii_PYR-1 ----------------MQPIPVIALTGYLGAGKTTLLNHVLR-SPDARIG
TH_4457|M.thermoresistible__bu ----------------VEPIPVIALTGYLGAGKTSLLNHVLR-TPGARIG
. :** . :
Mb0109|M.bovis_AF2122/97 HRFDGHVVRRMTATLSRGELITTEDALEFAHGCVSCTIRDDLL--VLLRR
Rv0106|M.tuberculosis_H37Rv HRFDGHVVRRMTATLSRGELITTEDALEFAHGCVSCTIRDDLL--VLLRR
MMAR_0293|M.marinum_M HRFDGHVVRRNIITFRRGELSTAEEVLELAHGCVSCTIRNDLL--ILLRR
MUL_4830|M.ulcerans_Agy99 HRFDGHVVRRNIITFRRGELSTAEEALELAHGCVSCTIRNDLL--ILLRR
MAV_4874|M.avium_104 HRFDGHVVRRTTAVLTDGVLTSTECGLELAHGCVSCTIRNDLL--VLLRQ
MAB_3425c|M.abscessus_ATCC_199 VVVNDFGAINIDAMLVAG---QVDSTMTMSNGCLCCTADDDELGGMLSAL
MSMEG_1123|M.smegmatis_MC2_155 ALVNDFGAVNIDAMLVAG---QVDAMAGLTNGCICCAVDADEAGEMLGKL
Mflv_1052|M.gilvum_PYR-GCK VVINDFGELNVDAGLVTG---QVDEPASIAGGCICCLPDEGGLDVALERL
Mvan_5779|M.vanbaalenii_PYR-1 VVINDFGELNVDAGLVTG---QVDEPASIAGGCICCLPDEGGLDSALARL
TH_4457|M.thermoresistible__bu VVINDFGDINVDASMVTG---QIDEPASIAGGCICCLPDDGELDVALAKL
.:.. . : * : :: **:.* . *
Mb0109|M.bovis_AF2122/97 LHRRDNVGRIVVHLAPWLEPQPICWAIDHVRVCVGHGYPDGPAALDVRVA
Rv0106|M.tuberculosis_H37Rv LHRRDNVGRIVVHLAPWLEPQPICWAIDHVRVCVGHGYPDGPAALDVRVA
MMAR_0293|M.marinum_M LHRRDGVDRIVVHLAPWLEPEPICWAINHVRVRVGPGYPDAPAGRDVRIG
MUL_4830|M.ulcerans_Agy99 LHRRDGVDRIVVHLAPWLEPEPICWAINHVRVRVGPGYPDAPAGRDVRIG
MAV_4874|M.avium_104 LHRRDDVDRIVVHLAPWLEPEPICLAINHVRVRVAPGGVDGPAALDVSIA
MAB_3425c|M.abscessus_ATCC_199 AGRD--IDAIVIEASGLAEPLPLVRMVLAATAED----------RRIGYG
MSMEG_1123|M.smegmatis_MC2_155 AAVKPRLDLIVVEASGLAEPAALARTI--AMADD----------TRYHYA
Mflv_1052|M.gilvum_PYR-GCK ADPKLRLDAIIVEASGLADPVAVSRIIRFSGVDG----------IRP--G
Mvan_5779|M.vanbaalenii_PYR-1 ADPKLRLDAIIVEASGLADPVAVSRIIRFSGVDG----------VRP--G
TH_4457|M.thermoresistible__bu ADPRLRLDAIIIEASGVAEPASIARMIGFSGVDG----------IRD--G
:. *::. : :* .: : . .
Mb0109|M.bovis_AF2122/97 AVVTCVDCVRWLPQSLGEDELPDGRTVAQVTVG-QAEFADLLVLTHPEPV
Rv0106|M.tuberculosis_H37Rv AVVTCVDCVRWLPQSLGEDELPDGRTVAQVTVG-QAEFADLLVLTHPEPV
MMAR_0293|M.marinum_M AVVTCVDSANWLAQSLGDEELADGRTFAQVTVG-QAEFADVLVLNRPDPV
MUL_4830|M.ulcerans_Agy99 AVVTCVDSANWLAQSLGDEELADGRTFAQVTVG-QAEFADVLVLNRPDPV
MAV_4874|M.avium_104 AVVTCVDSSTWLSQALGEDELDDGRTHAQVVIG-QAEFADVVVLDHPNPF
MAB_3425c|M.abscessus_ATCC_199 GLVTVVDTAQYEDVAVRHPEIAQHLDLADLVVLNKIDLADAGDRTHLR--
MSMEG_1123|M.smegmatis_MC2_155 GLVLVVD-----AVESTRAELGNNVQVADLVVVNKADQVSDAELEAVR--
Mflv_1052|M.gilvum_PYR-GCK GVVDVLDAATHFDTIDRDDAPPARYGPP----------------------
Mvan_5779|M.vanbaalenii_PYR-1 GVVDVLDAATHFDTVDRDATPPARYGAATLVVVNKLDRIPVRDRADALVR
TH_4457|M.thermoresistible__bu GVVDVIDAANHFDTVDRGDQPPARYGAATLVVVNKLDQIPEQERPALLRR
.:* :* .
Mb0109|M.bovis_AF2122/97 AVAVLRRLAPRARITGG-VDRVELALAHLDDNSRRGRTDTPHTPLLAGLP
Rv0106|M.tuberculosis_H37Rv AVAVLRRLAPRARITGG-VDRVELALAHLDDNSRRGRTDTPHTPLLAGLP
MMAR_0293|M.marinum_M TLAVLPRLAPRARITVG-LDRVELALANLDDYSRRGRSDHPHASLLGGRP
MUL_4830|M.ulcerans_Agy99 TLAVLPRLAPRARITVG-LDRVELALANLDDYSRRGRSDHPHASLLGGRP
MAV_4874|M.avium_104 LAAVLRRLAPRARVRVG-ADGIDDALNNLYRDARRGRVDDPHGPLLAGQP
MAB_3425c|M.abscessus_ATCC_199 --AVVKERNPRASIVETTGADVDPRLLFDKKERPEPVGQLSLEDLIREDH
MSMEG_1123|M.smegmatis_MC2_155 --AKITALNDRVPVLPTEFGRVDPELLVDPPQQVPRVAQLSLDELLWETY
Mflv_1052|M.gilvum_PYR-GCK -------------------------------------------PWWSSTS
Mvan_5779|M.vanbaalenii_PYR-1 IESRVRELNPHAHVVGATAGRIDPALLYDVAGDAETLGQLTFRELWSDAE
TH_4457|M.thermoresistible__bu VEDRVRERNPRAHIVGTTGGRIDPALLYDVASAQDETGQLSFRDLFIEPS
Mb0109|M.bovis_AF2122/97 PLAADG-------EVAIVEFSARRPFHPQRLHAAVDLLLDGVVRTRGRLW
Rv0106|M.tuberculosis_H37Rv PLAADG-------EVAIVEFSARRPFHPQRLHAAVDLLLDGVVRTRGRLW
MMAR_0293|M.marinum_M PLGTDG-------GVGIVEFNARRPFRPERLHDAVDHLLDGVIRTRGRLW
MUL_4830|M.ulcerans_Agy99 PLGTDG-------GVGIVEFNARRPFRPERLHDAVDHLLDGVIRTRGRLW
MAV_4874|M.avium_104 PLDARG-------PIRLVEFNSRRPFHPGRLHACLDLLLDGVIRTRGRLW
MAB_3425c|M.abscessus_ATCC_199 SHEH-----HAHHHYETVEFATEQPLHPRRLIEFLDSQPAGVYRIKGLVR
MSMEG_1123|M.smegmatis_MC2_155 DHDH-----HEHATFQSVAFTSDVPLDPRRFMDLLKNRPAGMYRAKGFVD
Mflv_1052|M.gilvum_PYR-GCK STGY----------------------------------------------
Mvan_5779|M.vanbaalenii_PYR-1 AQAHPHVHDHDHSHADSVTVTGEGCVDPAAVIDLLEAPPDGVYRMKGTVA
TH_4457|M.thermoresistible__bu DHGAHG--DHDHVHADSVTVTSTGTVDPVRLVELLEDPPARVYRLKGTVA
Mb0109|M.bovis_AF2122/97 LANRPDQVMWLESAGGGLRVASAGKWLAAMAASEVAYVDLERRLFADLMW
Rv0106|M.tuberculosis_H37Rv LANRPDQVMWLESAGGGLRVASAGKWLAAMAASEVAYVDLERRLFADLMW
MMAR_0293|M.marinum_M LANRPDQVMWLESAGGGLRVASAGKWLAAMSPAEVDHADPERRLFAELMW
MUL_4830|M.ulcerans_Agy99 LANRPDQVMWLESAGGGLRVAWAGKWLAAMSPAEVDHADPERRLFAEMMW
MAV_4874|M.avium_104 LASRADRAMWLESAGAGLRVSSAGKWLAAMTGPERDGIDAQRRVLAALGW
MAB_3425c|M.abscessus_ATCC_199 LGD----RTLAVHTVGDHISFDKVGRASDFSSG-----------------
MSMEG_1123|M.smegmatis_MC2_155 FGDAGEGRKFVLQLVGGSLRFERRRWDRGEARR-----------------
Mflv_1052|M.gilvum_PYR-GCK -RPRSVPRRWSASRAGSAR-------------------------------
Mvan_5779|M.vanbaalenii_PYR-1 VRYRSSSRCYSVNVVGPSVHIAVA---PPRAVA-----------------
TH_4457|M.thermoresistible__bu VRQRSNPRHYLINAVGSAVHVTTR---RSRVSE-----------------
.
Mb0109|M.bovis_AF2122/97 VYPFGDRHTAMTVLVCGADPTDIVNALNAALLSDDEMASPQRWQSYVDPF
Rv0106|M.tuberculosis_H37Rv VYPFGDRHTAMTVLVCGADPTDIVNALNAALLSDDEMASPQRWQSYVDPF
MMAR_0293|M.marinum_M EYRFGDRHTAMTVLACGADRAEITRVLTGALLTDREMARPQDWPAYDDPF
MUL_4830|M.ulcerans_Agy99 EYRFGDRHTAMTVLACGADRAEITRVLTGALLTDREMARPQDWPAYDDPF
MAV_4874|M.avium_104 DDRHGDRHTAMAILVCGADPAEILDALQAALLTDEELERPGEWQGYDDPF
MAB_3425c|M.abscessus_ATCC_199 --------ASLVLIGTHLDGDTITERLRTLIDDPPDPDRERSMLVLGKYL
MSMEG_1123|M.smegmatis_MC2_155 --------TSLVLIGTDIDEAAALSALQGCAT--AEPADKQAILGVLRYT
Mflv_1052|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5779|M.vanbaalenii_PYR-1 --------NSLVAIGMGLDVEAVRERMRSALTPVQGAASAHGLRRLQRYR
TH_4457|M.thermoresistible__bu --------NSLVAIGMGLDIDAVRTRLSTALQPFDGPTSAAALRRLQRYQ
Mb0109|M.bovis_AF2122/97 GDWHDDPCHEMPDAAGEFSAHRNSGESR
Rv0106|M.tuberculosis_H37Rv GDWHDDPCHEMPDAAGEFSAHRNSGESR
MMAR_0293|M.marinum_M GDWHEDPCHETPDESGQFSGHLNKGELE
MUL_4830|M.ulcerans_Agy99 GDWHEDPCHETPDESGQFSGHLNKGELE
MAV_4874|M.avium_104 GDWHEEPCVGLEAADNAAQGARQDPDPS
MAB_3425c|M.abscessus_ATCC_199 R---------------------------
MSMEG_1123|M.smegmatis_MC2_155 D---------------------------
Mflv_1052|M.gilvum_PYR-GCK ----------------------------
Mvan_5779|M.vanbaalenii_PYR-1 KLSI------------------------
TH_4457|M.thermoresistible__bu AGVG------------------------