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MPDLLPVTVLSGFLGAGKTTLLNHILANRDGKRVAVIVNDMSEVNIDAALIAGQGHLDRTEEKLVELTNG CICCTLREDLVEAVGALARQNRFDQLVIESTGISEPMPVAATFSWEFDDGFSLGALARLDTLVTVVDVST FLIELARGEALAEREMTAGPNDARSVADLLVDQVEFADVILLNKTDLVTAERLGAVEAVVRRLNPTARLL HTDHGVVALDEVLDTGLFDPVAAAEAPGWDEEIAMGHTPETEEYGIGSLTFLADRPFHPQRLADALEKMT GLLRSKGFCWIASRPSVAAIWSQAGPNLVIEPAQLWSSTELDPGQELVFIGVHIDRDAIGDMLCSALLTD SEWAQGEHAWLRYPDPLPAWDLTHVHAH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6048 | - | - | 100% (378) | cobalamin synthesis protein/P47K |
| M. smegmatis MC2 155 | MSMEG_1123 | - | 1e-31 | 32.24% (366) | cobalamin synthesis protein |
| M. smegmatis MC2 155 | MSMEG_6069 | - | 2e-25 | 30.52% (344) | CobW/P47K domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0109 | - | 9e-23 | 28.05% (353) | hypothetical protein Mb0109 |
| M. gilvum PYR-GCK | Mflv_1313 | - | 2e-22 | 28.61% (339) | cobalamin synthesis CobW domain-containing protein |
| M. tuberculosis H37Rv | Rv0106 | - | 9e-23 | 28.05% (353) | hypothetical protein Rv0106 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1046c | - | 1e-161 | 74.80% (373) | cobalamin synthesis protein P47K/CobW |
| M. marinum M | MMAR_0293 | - | 9e-28 | 29.65% (344) | hypothetical protein MMAR_0293 |
| M. avium 104 | MAV_4874 | - | 5e-22 | 29.59% (338) | CobW/P47K domain-containing protein |
| M. thermoresistible (build 8) | TH_4457 | - | 5e-22 | 27.17% (357) | PUTATIVE cobalamin synthesis protein, P47K |
| M. ulcerans Agy99 | MUL_4830 | - | 2e-27 | 30.00% (350) | hypothetical protein MUL_4830 |
| M. vanbaalenii PYR-1 | Mvan_5321 | - | 1e-178 | 81.07% (375) | cobalamin synthesis protein, P47K |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6048|M.smegmatis_MC2_155 ------MP----DLLPVTVLSGFLGAGKTTLLNHILANRDGKRVAVIVND
Mvan_5321|M.vanbaalenii_PYR-1 MIIIKNMSSAPAPLLPVTVLSGFLGAGKTTLLNHILANREGRRVAVIVND
MAB_1046c|M.abscessus_ATCC_199 ------MTT--AQLLPVTVLSGFLGAGKTTLLNHILANTEGRRVAVIVND
Mb0109|M.bovis_AF2122/97 ---------------MRTPVILVAGQDHTDEVTGALLRRTG--TVVVEHR
Rv0106|M.tuberculosis_H37Rv ---------------MRTPVILVAGQDHTDEVTGALLRRTG--TVVVEHR
MMAR_0293|M.marinum_M ---------------MRTPVVLVAGQGDTDDVTGLLLRRPG--TVVVEHR
MUL_4830|M.ulcerans_Agy99 ---------------MRTPVVLVAGQGDTDDVTGLLLRRPG--TVVVEHR
MAV_4874|M.avium_104 --------------------------------MGALLRTSG--TLVVEHR
Mflv_1313|M.gilvum_PYR-GCK ---------------MRTPVVVVTGQSDTGDIGDLLLADGA--TALVEHH
TH_4457|M.thermoresistible__bu -----------VEPIPVIALTGYLGAGKTSLLNHVLR-TPGARIGVVIND
* . :: :
MSMEG_6048|M.smegmatis_MC2_155 MSEVNIDAALIAGQGHLDRTEEKLVELTNGCICCTLRE-DLVEAVGALAR
Mvan_5321|M.vanbaalenii_PYR-1 MSEVNIDAALVAGQGHLDRTQEKLVELTNGCICCTLRE-DLIEAVGALAR
MAB_1046c|M.abscessus_ATCC_199 MSEVNIDAALVAGTGHLDRTEERLVELTNGCICCTLRE-DLIEAVGNLAR
Mb0109|M.bovis_AF2122/97 FDGHVVRRMTATLSRGELITTEDALEFAHGCVSCTIRD-DLLVLLRRLHR
Rv0106|M.tuberculosis_H37Rv FDGHVVRRMTATLSRGELITTEDALEFAHGCVSCTIRD-DLLVLLRRLHR
MMAR_0293|M.marinum_M FDGHVVRRNIITFRRGELSTAEEVLELAHGCVSCTIRN-DLLILLRRLHR
MUL_4830|M.ulcerans_Agy99 FDGHVVRRNIITFRRGELSTAEEALELAHGCVSCTIRN-DLLILLRRLHR
MAV_4874|M.avium_104 FDGHVVRRTTAVLTDGVLTSTECGLELAHGCVSCTIRN-DLLVLLRQLHR
Mflv_1313|M.gilvum_PYR-GCK VEGHVVHRTTTVLRRGVVVKAVSVVEMTNGCPSCAVRE-DLVDHLCRLHL
TH_4457|M.thermoresistible__bu FGDINVDASMVTG------QIDEPASIAGGCICCLPDDGELDVALAKLAD
. : . .:: ** .* : :* : *
MSMEG_6048|M.smegmatis_MC2_155 -QNRFDQLVIESTGISEPMPVAATFSWEFDD------GFSLGALARLDTL
Mvan_5321|M.vanbaalenii_PYR-1 -QQRFDQLVIESTGISEPMPVAATFSWEFED------GSSLGQLARLDTL
MAB_1046c|M.abscessus_ATCC_199 -QNRFDQLVIESTGISEPMPVAASFTWEFED------GTSLGQVARLDTM
Mb0109|M.bovis_AF2122/97 -RDNVGRIVVHLAPWLEPQPICWAIDHVRVCVGHGYPDGPAALDVRVAAV
Rv0106|M.tuberculosis_H37Rv -RDNVGRIVVHLAPWLEPQPICWAIDHVRVCVGHGYPDGPAALDVRVAAV
MMAR_0293|M.marinum_M -RDGVDRIVVHLAPWLEPEPICWAINHVRVRVGPGYPDAPAGRDVRIGAV
MUL_4830|M.ulcerans_Agy99 -RDGVDRIVVHLAPWLEPEPICWAINHVRVRVGPGYPDAPAGRDVRIGAV
MAV_4874|M.avium_104 -RDDVDRIVVHLAPWLEPEPICLAINHVRVRVAPGGVDGPAALDVSIAAV
Mflv_1313|M.gilvum_PYR-GCK -RPDVARIAVLLSPWMEPEPVCVALTRS-----------TAARHVAVSAV
TH_4457|M.thermoresistible__bu PRLRLDAIIIEASGVAEPASIARMIGFSGVDG------------IRDGGV
: . : : : ** .:. : :
MSMEG_6048|M.smegmatis_MC2_155 VTVVDVSTFLIELARGEALAEREMTAGPNDARSVADLLVDQVEFADVILL
Mvan_5321|M.vanbaalenii_PYR-1 VTVVDASTFLTEIARGEALADRDLTAGEGDARSISDLLVDQVEFADVILL
MAB_1046c|M.abscessus_ATCC_199 VTVVDASTFLPELARGESLADREMAAANGDGRSIADLLTDQVEFADVLIL
Mb0109|M.bovis_AF2122/97 VTCVDCVRWLPQSLGEDELPD---------GRTVAQVTVGQAEFADLLVL
Rv0106|M.tuberculosis_H37Rv VTCVDCVRWLPQSLGEDELPD---------GRTVAQVTVGQAEFADLLVL
MMAR_0293|M.marinum_M VTCVDSANWLAQSLGDEELAD---------GRTFAQVTVGQAEFADVLVL
MUL_4830|M.ulcerans_Agy99 VTCVDSANWLAQSLGDEELAD---------GRTFAQVTVGQAEFADVLVL
MAV_4874|M.avium_104 VTCVDSSTWLSQALGEDELDD---------GRTHAQVVIGQAEFADVVVL
Mflv_1313|M.gilvum_PYR-GCK VATVDTSVWLHQALGDDELDD---------GRTVAQVVVGQVEFADVVVL
TH_4457|M.thermoresistible__bu VDVIDAANHFDTVDRGDQPPA----------RYGAATLVVVNKLDQIPEQ
* :* : : * : :: ::
MSMEG_6048|M.smegmatis_MC2_155 NKTDLVTAERLGAVEAVVRRLNPTARLLHTDHGVVALDEVLDTG--LFDP
Mvan_5321|M.vanbaalenii_PYR-1 NKTDLVSAATLGTAETLVRRLNPTAKLIRTDHGVVDIAEVLDTG--LFDP
MAB_1046c|M.abscessus_ATCC_199 NKVDLVNERTLGMVETLLRRLNPTATIVRSTAGVVDLDLVLQTG--LFDP
Mb0109|M.bovis_AF2122/97 THPEPVAVAVL-------RRLAPRARIT---GGVDRVELALAH---LDDN
Rv0106|M.tuberculosis_H37Rv THPEPVAVAVL-------RRLAPRARIT---GGVDRVELALAH---LDDN
MMAR_0293|M.marinum_M NRPDPVTLAVL-------PRLAPRARIT---VGLDRVELALAN---LDDY
MUL_4830|M.ulcerans_Agy99 NRPDPVTLAVL-------PRLAPRARIT---VGLDRVELALAN---LDDY
MAV_4874|M.avium_104 DHPNPFLAAVL-------RRLAPRARVR---VGADGIDDALNN---LYRD
Mflv_1313|M.gilvum_PYR-GCK TEAHRDTLAVV-------RRLAPAARIT---VGVSRFTLALAN---LDAD
TH_4457|M.thermoresistible__bu ERPALLRRVEDR-----VRERNPRAHIVGTTGGRIDPALLYDVASAQDET
. . * * : *
MSMEG_6048|M.smegmatis_MC2_155 VAAAEAPGWDEEIAMGHTPETEEYGIGSLTFLADRPFHPQRLADALEKMT
Mvan_5321|M.vanbaalenii_PYR-1 IAAEEAPGWDEEIADGHTPETEEYGISSMTFHSDRPFHPQRLAESLGKMT
MAB_1046c|M.abscessus_ATCC_199 DLAAQTPGWDEEIADGHTPETEEYGISSMTFRSDRPFHPHRLNTALENMQ
Mb0109|M.bovis_AF2122/97 SRRGRTDTPHTPLLAGLPPLAADGEVAIVEFSARRPFHPQRLHAAVDLLL
Rv0106|M.tuberculosis_H37Rv SRRGRTDTPHTPLLAGLPPLAADGEVAIVEFSARRPFHPQRLHAAVDLLL
MMAR_0293|M.marinum_M SRRGRSDHPHASLLGGRPPLGTDGGVGIVEFNARRPFRPERLHDAVDHLL
MUL_4830|M.ulcerans_Agy99 SRRGRSDHPHASLLGGRPPLGTDGGVGIVEFNARRPFRPERLHDAVDHLL
MAV_4874|M.avium_104 ARRGRVDDPHGPLLAGQPPLDARGPIRLVEFNSRRPFHPGRLHACLDLLL
Mflv_1313|M.gilvum_PYR-GCK ARRGRGNDPHGSLLAGQPPLEPAGRVRLVEFAARRPFHPSRLHAAVDLLL
TH_4457|M.thermoresistible__bu GQLSFRDLFIEPSDHGAHGDHDHVHADSVTVTSTGTVDPVRLVELLEDPP
* : . : .. * ** :
MSMEG_6048|M.smegmatis_MC2_155 G-LLRSKGFCWIASRPSVAAIWSQAGPNLVIEPAQLWSSTELDPGQE---
Mvan_5321|M.vanbaalenii_PYR-1 R-ILRSKGFCWIASRPTIAAIWSQAGPNLVIEPAQYWSSTEIAPGQE---
MAB_1046c|M.abscessus_ATCC_199 G-LLRSKGFCWIASRDDIAAIWSQAGPNLTIEPAQFWHSTEIAPGQE---
Mb0109|M.bovis_AF2122/97 DGVVRTRGRLWLANRPDQVMWLESAGGGLRVASAGKWLAAMAASEVAYVD
Rv0106|M.tuberculosis_H37Rv DGVVRTRGRLWLANRPDQVMWLESAGGGLRVASAGKWLAAMAASEVAYVD
MMAR_0293|M.marinum_M DGVIRTRGRLWLANRPDQVMWLESAGGGLRVASAGKWLAAMSPAEVDHAD
MUL_4830|M.ulcerans_Agy99 DGVIRTRGRLWLANRPDQVMWLESAGGGLRVAWAGKWLAAMSPAEVDHAD
MAV_4874|M.avium_104 DGVIRTRGRLWLASRADRAMWLESAGAGLRVSSAGKWLAAMTGPERDGID
Mflv_1313|M.gilvum_PYR-GCK EGVVRSRGRLWLAHLPDMAVGLDSAGGGLLVTRAGKWLAAMTSRELAYVG
TH_4457|M.thermoresistible__bu ARVYRLKGTVAVRQRSNPRHYLINAVGSAVHVTTRRSRVSENS-------
: * :* : .* . : :
MSMEG_6048|M.smegmatis_MC2_155 ---------------------LVFIGVHIDRDAIGDMLCSALLTDS--EW
Mvan_5321|M.vanbaalenii_PYR-1 ---------------------IVFIGVKLDRDKVRRLLEDALLTDA--EL
MAB_1046c|M.abscessus_ATCC_199 ---------------------IVFIGVRLDRPRVQHLLESAVLTDD--EL
Mb0109|M.bovis_AF2122/97 LERRLFADLMWVYPFGDRHTAMTVLVCGADPTDIVNALNAALLSDD--EM
Rv0106|M.tuberculosis_H37Rv LERRLFADLMWVYPFGDRHTAMTVLVCGADPTDIVNALNAALLSDD--EM
MMAR_0293|M.marinum_M PERRLFAELMWEYRFGDRHTAMTVLACGADRAEITRVLTGALLTDR--EM
MUL_4830|M.ulcerans_Agy99 PERRLFAEMMWEYRFGDRHTAMTVLACGADRAEITRVLTGALLTDR--EM
MAV_4874|M.avium_104 AQRRVLAALGWDDRHGDRHTAMAILVCGADPAEILDALQAALLTDE--EL
Mflv_1313|M.gilvum_PYR-GCK AERRAMADMMWDDRYGDRHTSMTVLVCGADPAEIVSALRGALLTDA--EM
TH_4457|M.thermoresistible__bu ---------------------LVAIGMGLDIDAVRTRLSTALQPFDGPTS
:. : * : * *: .
MSMEG_6048|M.smegmatis_MC2_155 AQGEHAWLRYPDPLPAWDLTHVHAH-----------------
Mvan_5321|M.vanbaalenii_PYR-1 AEGEQIWTEYADPLPAWGVTHSHAN-----------------
MAB_1046c|M.abscessus_ATCC_199 AGGPELWRSFTDPLPAWGVMHAH-------------------
Mb0109|M.bovis_AF2122/97 AS-PQRWQSYVDPFGDWHDDPCHEMPDAAGEFSAHRNSGESR
Rv0106|M.tuberculosis_H37Rv AS-PQRWQSYVDPFGDWHDDPCHEMPDAAGEFSAHRNSGESR
MMAR_0293|M.marinum_M AR-PQDWPAYDDPFGDWHEDPCHETPDESGQFSGHLNKGELE
MUL_4830|M.ulcerans_Agy99 AR-PQDWPAYDDPFGDWHEDPCHETPDESGQFSGHLNKGELE
MAV_4874|M.avium_104 ER-PGEWQGYDDPFGDWHEEPCVGLEAADNAAQGARQDPDPS
Mflv_1313|M.gilvum_PYR-GCK GR-PQDWPRFDDPFGDWHPQEARLA-----------------
TH_4457|M.thermoresistible__bu AAALRRLQRYQAGVG---------------------------
: .