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MRVLLTGAAGFIGSRIAVALRDAGHEVIGVDAMLPAAHRTGAQPPEGCELIDVRDADALAPLLSGVDVVC HQAAVVGAGVNPGDAPSYASHNVLGTAVLLAQMFEAGCTRLVLASSMVVYGQGRFYCVEHGEIDPMPRSR ADLDAGVFEHRCPVGEEPLRWQLVGEDAPVRPRSLYAASKAAQEHYALAWAVAVGGSVVALRYHNVYGPG MPRDTPYSGVAAIFRSQLESGDVPRVFEDGGQMRDFVHVDDVAAANLAAVHAVDGGLDGFHPFNVCSGRP ISIMDVATQLCEVRGAPGPVVTGQYRSGDVRHIVADPARAHEVLGFRAAIDPRDGLREFAFARLRD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0991 | - | - | 100% (346) | NAD-dependent epimerase/dehydratase |
| M. smegmatis MC2 155 | MSMEG_0386 | - | 2e-44 | 36.15% (343) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 4e-26 | 32.46% (345) | nucleoside-diphosphate-sugar epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0550 | galE3 | 1e-149 | 74.86% (346) | UDP-glucose 4-epimerase |
| M. gilvum PYR-GCK | Mflv_1401 | - | 3e-18 | 28.11% (338) | UDP-glucose 4-epimerase |
| M. tuberculosis H37Rv | Rv0536 | galE3 | 1e-149 | 74.86% (346) | UDP-glucose 4-epimerase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 5e-22 | 29.77% (346) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_4111c | - | 2e-43 | 35.57% (343) | putative epimerase/dehydratase |
| M. marinum M | MMAR_0882 | galE3 | 1e-147 | 73.41% (346) | UDP-glucose 4-epimerase, GalE3 |
| M. avium 104 | MAV_4609 | - | 1e-147 | 75.58% (344) | NAD-dependent epimerase/dehydratase |
| M. thermoresistible (build 8) | TH_3729 | - | 6e-20 | 28.61% (360) | PUTATIVE UDP-galactose 4-epimerase |
| M. ulcerans Agy99 | MUL_0635 | galE3 | 1e-146 | 73.12% (346) | UDP-glucose 4-epimerase, GalE3 |
| M. vanbaalenii PYR-1 | Mvan_0882 | - | 1e-150 | 75.07% (345) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0550|M.bovis_AF2122/97 -----MRVLLTGAAGFIGSRVDAALRAAGHDVVGVDALLPAAHG------
Rv0536|M.tuberculosis_H37Rv -----MRVLLTGAAGFIGSRVDAALRAAGHDVVGVDALLPAAHG------
MMAR_0882|M.marinum_M -----MKVLLTGAAGFIGSRVGAALSAAGHEVVGVDVLLPAAHG------
MUL_0635|M.ulcerans_Agy99 -----MKVLLTGAAGFIGSRVGAALSAAGHEVVGVDVLLPAAHG------
MAV_4609|M.avium_104 -------MLVTGAAGFIGSRVAAALRAAGHDVVAVDALLAAAHG------
Mvan_0882|M.vanbaalenii_PYR-1 -----MRVLLTGAAGFIGTRIRERLIDGGHDVVAVDAMLPAAHG------
MSMEG_0991|M.smegmatis_MC2_155 -----MRVLLTGAAGFIGSRIAVALRDAGHEVIGVDAMLPAAHR------
MAB_4111c|M.abscessus_ATCC_199 -------MLISGGAGFIGSALSNRLIQAGYDVAVMDVLHPQVHARGRAID
MLBr_00204|M.leprae_Br4923 MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVVGLDNFATGHAAN---LE
Mflv_1401|M.gilvum_PYR-GCK -----MSWLITGGAGYIGSHVARAMLEAGRDVVVIDDLSSGFES------
TH_3729|M.thermoresistible__bu -----MTWLVTGGAGYIGSHVVRALLEADLPVVVIDDLSTGLEK------
*::*.**:**: : : . * :* : .
Mb0550|M.bovis_AF2122/97 -PNPVLPPGCQRVDVRDASALAPLLAG--VDLVCHQAAMVGAGVNAADAP
Rv0536|M.tuberculosis_H37Rv -PNPVLPPGCQRVDVRDASALAPLLAG--VDLVCHQAAMVGAGVNAADAP
MMAR_0882|M.marinum_M -PNPVLPPGCHRVDVRDADAMAPLLAG--VDLVCHQAAMVGAGVDAADAP
MUL_0635|M.ulcerans_Agy99 -PNPVLPPGCHRVDVRDADAMAPLLAG--VDLVCHQAAMVGAGVDAADAP
MAV_4609|M.avium_104 -PNPLPPNGCHRVDVRDADALAPLLAG--VDVVCHQAAMVGAGVDAADAP
Mvan_0882|M.vanbaalenii_PYR-1 -EDAAPPDDVARVDVRDAAAVADAVAG--VDVVCHQAAVVGAGVDAADAP
MSMEG_0991|M.smegmatis_MC2_155 -TGAQPPEGCELIDVRDADALAPLLSG--VDVVCHQAAVVGAGVNPGDAP
MAB_4111c|M.abscessus_ATCC_199 LPASVRLFTGDVTHAPDWDAVLRLFE---PSQVVHLAAETGTAQSLSEAT
MLBr_00204|M.leprae_Br4923 HLASTPALAFVEADIVTADLQTILDEHR-PEVVFHLAAQIDVRHSVVDPQ
Mflv_1401|M.gilvum_PYR-GCK --FVPDGAAFVEGTLLDAALVDDTLARFDVDGVIHIAGYKYAGESVKRPL
TH_3729|M.thermoresistible__bu --FVPSEVPLVRGTLLDADLVARALREHRVSGVIHIAGFKYAGVSVQQPL
. * * *. . . .
Mb0550|M.bovis_AF2122/97 AYGGHNDFATTVLLAQMFAAGVR--RLVLASSMVVYGQGRYDCPQHGPVD
Rv0536|M.tuberculosis_H37Rv AYGGHNDFATTVLLAQMFAAGVR--RLVLASSMVVYGQGRYDCPQHGPVD
MMAR_0882|M.marinum_M AYGGHNDLATTVLLAQMFAAGVR--RLVLASSMVVYGQGRYDCPEHGRID
MUL_0635|M.ulcerans_Agy99 AYGGHNDLATTVLLAQMFAAGVR--RLVLASSMVVYGQGHYDCPEHGRID
MAV_4609|M.avium_104 AYGGHNDLATTVLLAQMFAAGVR--RLVLASSMVVYGQGGYRCERHGPVH
Mvan_0882|M.vanbaalenii_PYR-1 SYAAHNDFATAVLLAQMFGAGCR--RLVLASSMVVYGQGRYVCPGHGDVD
MSMEG_0991|M.smegmatis_MC2_155 SYASHNVLGTAVLLAQMFEAGCT--RLVLASSMVVYGQGRFYCVEHGEID
MAB_4111c|M.abscessus_ATCC_199 RHGSVNVVGTTQLLDALSRSALVPDQLVLASSRAVYGEGAWQS-GAEVFY
MLBr_00204|M.leprae_Br4923 FDASVNVIGTVRLAEAARHTGVR---------KIVHTSSGGSIYGTPSQY
Mflv_1401|M.gilvum_PYR-GCK HTYEQNVSTTVILLQAMEARGVG--QIVFSSSAATFGTP-----------
TH_3729|M.thermoresistible__bu HTYEQNVSAMVTLLKAMQDTGVD--MMVFSSSAATFGTP-----------
* . * . ..
Mb0550|M.bovis_AF2122/97 PLPRRRADLDNGVFEHRCPGCGEPVIWQLVDEDAPLRPRSLYAASKTAQE
Rv0536|M.tuberculosis_H37Rv PLPRRRADLDNGVFEHRCPGCGEPVIWQLVDEDAPLRPRSLYAASKTAQE
MMAR_0882|M.marinum_M PLPRRHSDLDAGVFEHRCPLCAEPVRWRLVGEEAELRPRSLYAASKTAQE
MUL_0635|M.ulcerans_Agy99 PLPRRHSDLDAGVFEHRCPLCAEPVRWRLVGEEAELRPRSLYAASKTAQE
MAV_4609|M.avium_104 PLPRRRADLDAGVFEHRCPIGGEELRWQLVDEDACLRPRSLYAASKTAQE
Mvan_0882|M.vanbaalenii_PYR-1 PVPRTRSDLDAGAFDHRCPICGEPVDWALVGEGAPLRPRSLYAASKVAQE
MSMEG_0991|M.smegmatis_MC2_155 PMPRSRADLDAGVFEHRCPVGEEPLRWQLVGEDAPVRPRSLYAASKAAQE
MAB_4111c|M.abscessus_ATCC_199 PRPRSHAQLLAGEWDPQGPAGASATPLSSCADRTEPRPTNIYAGTKLAQE
MLBr_00204|M.leprae_Br4923 PTP----------------------------ETVPTDPTSPYAAGKVAGE
Mflv_1401|M.gilvum_PYR-GCK -------------------------DVDIVDESTPTTPESPYGETKLIGE
TH_3729|M.thermoresistible__bu -------------------------DVDLVTETTPTRPESPYGESKLIGE
: . * . *. * *
Mb0550|M.bovis_AF2122/97 HYALAWSEASGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSAVEKGK
Rv0536|M.tuberculosis_H37Rv HYALAWSEASGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSAVEKGK
MMAR_0882|M.marinum_M HYALAWSESTGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSSLEKGE
MUL_0635|M.ulcerans_Agy99 HYALAWSESTGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSSLEKGE
MAV_4609|M.avium_104 HYALAWSEATGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSALEKGE
Mvan_0882|M.vanbaalenii_PYR-1 HYALAWSESTGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSALEAGD
MSMEG_0991|M.smegmatis_MC2_155 HYALAWAVAVGGSVVALRYHNVYGPGMP--RDTPYSGVAAIFRSQLESGD
MAB_4111c|M.abscessus_ATCC_199 HLLASWAAAHDTNLSVLRLQNVYGPGQS--LTNSYTGIVTLFARLAREKQ
MLBr_00204|M.leprae_Br4923 IYLNTFRHLCGLDCSHIAPANVYGPRQD--PYG-EAGVVAIFVQALLSDR
Mflv_1401|M.gilvum_PYR-GCK WLLRDAGRASGLRHTSLRYFNVVGSGAVELFDASPHNLFPLVFDMLFRGE
TH_3729|M.thermoresistible__bu WLLADVGRATGLRHTSLRYFNVVGSGSPELFDVSPHNLFPLVFDMLYRGE
. : ** *. .: .:.
Mb0550|M.bovis_AF2122/97 PPKVFED------GGQMRDFVHVDDVAAANLAAVHLGEADRDGFTAVNVC
Rv0536|M.tuberculosis_H37Rv PPKVFED------GGQMRDFVHVDDVAAANLAAVHLGEADRDGFTAVNVC
MMAR_0882|M.marinum_M PPKVFED------GGQMRDFVHVDDIAAANLAAAQLGEVDRHGFVAANVC
MUL_0635|M.ulcerans_Agy99 PPKVFED------GGQMRDFVHVDDIAAANLAAAQLGEVDRHGFVAANVC
MAV_4609|M.avium_104 PPRVFED------GGQMRDFVHVDDVAAANLAALAC----RDGFTAVNVC
Mvan_0882|M.vanbaalenii_PYR-1 VPRVFED------GGQMRDFVHVDDVAAANVAAVEAG---TEGFNAFNVC
MSMEG_0991|M.smegmatis_MC2_155 VPRVFED------GGQMRDFVHVDDVAAANLAAVHAVDGGLDGFHPFNVC
MAB_4111c|M.abscessus_ATCC_199 ALEVYED------GRIVRDFVFIDDVVDALFAAVHTP---ATERRTLDIG
MLBr_00204|M.leprae_Br4923 PTKVFGD------GTHTRDYVFVDDVVDAFIKASGDAG----GGQRFNIG
Mflv_1401|M.gilvum_PYR-GCK TPRINGDDYPTPDGTCVRDYIHVSDLALAHVAAAQRLAAGEPVEPVYNLG
TH_3729|M.thermoresistible__bu TPRINGDDYPTPDGTCVRDYIHVADLALAHVAAARRLQAGEPVEPVYNLG
.: * * **::.: *:. * . * ::
Mb0550|M.bovis_AF2122/97 SGRPISILQVATAICDARGGSMSPAITGHYRSGDVRHIVADPARAARVLG
Rv0536|M.tuberculosis_H37Rv SGRPISILQVATAICDARGGSMSPAITGHYRSGDVRHIVADPARAARVLG
MMAR_0882|M.marinum_M SGRPISILQVASALCQARGDALSPVITGQYRSGDVRHIVADPSRAAEVLG
MUL_0635|M.ulcerans_Agy99 SGRPISILQVASALCQARGDALSPVITGQYRSGDVRHIVADPSRAAEVLG
MAV_4609|M.avium_104 SGQPISILQVATALCDARGGAVAPVVTGQYRSGDVRHIVADPSRAARLLG
Mvan_0882|M.vanbaalenii_PYR-1 SGKPVSILDVATALCEARG-DVSPLVTGQYRSGDVRHIVADPARAADVLG
MSMEG_0991|M.smegmatis_MC2_155 SGRPISIMDVATQLCEVRG-APGPVVTGQYRSGDVRHIVADPARAHEVLG
MAB_4111c|M.abscessus_ATCC_199 SGTATTIHELARKVADICA-APEPVVVGKFRDGDVRAASCDIAPAVEGLG
MLBr_00204|M.leprae_Br4923 TGIETSDRQLHTAVSAAVGGPDDPEFH-PPRLGDLKRSCLDIGLATTVLG
Mflv_1401|M.gilvum_PYR-GCK SGAGTSVREIMTAMRTVTGVDFEPVVM-PRRPGDPARIVAAGDLAARDLG
TH_3729|M.thermoresistible__bu SGSGTSVREIMTAIRKVTGVDFVPEIA-PRRPGDPARIVASGELAARDLG
:* : :: : . * . * ** * **
Mb0550|M.bovis_AF2122/97 FRAAVDPGEGLREFAFAPLR-------
Rv0536|M.tuberculosis_H37Rv FRAAVDPGEGLREFAFAPLR-------
MMAR_0882|M.marinum_M FRAAVEPLEGLRGFAFAPLR-------
MUL_0635|M.ulcerans_Agy99 FRAAVEPLEGLRGFAFAPLR-------
MAV_4609|M.avium_104 FRAAVQPGDGLREFAFAPLR-------
Mvan_0882|M.vanbaalenii_PYR-1 FRAVVDPADGLCEFATAPLRGPALPS-
MSMEG_0991|M.smegmatis_MC2_155 FRAAIDPRDGLREFAFARLRD------
MAB_4111c|M.abscessus_ATCC_199 WSPKWTLEDGLHALLEWIDKDCPNRF-
MLBr_00204|M.leprae_Br4923 WSPQVQLDDGVRRTVEYFRAAQRS---
Mflv_1401|M.gilvum_PYR-GCK WSNRHSLEEMVASAWRARQHAGDAYPR
TH_3729|M.thermoresistible__bu WRMRHTLEDMVKSAWEARQRAGDAYPR
: : :