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LISGGAGFIGSALSNRLIQAGYDVAVMDVLHPQVHARGRAIDLPASVRLFTGDVTHAPDWDAVLRLFEPS QVVHLAAETGTAQSLSEATRHGSVNVVGTTQLLDALSRSALVPDQLVLASSRAVYGEGAWQSGAEVFYPR PRSHAQLLAGEWDPQGPAGASATPLSSCADRTEPRPTNIYAGTKLAQEHLLASWAAAHDTNLSVLRLQNV YGPGQSLTNSYTGIVTLFARLAREKQALEVYEDGRIVRDFVFIDDVVDALFAAVHTPATERRTLDIGSGT ATTIHELARKVADICAAPEPVVVGKFRDGDVRAASCDIAPAVEGLGWSPKWTLEDGLHALLEWIDKDCPN RF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4111c | - | - | 100% (353) | putative epimerase/dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 4e-31 | 29.36% (344) | UDP-glucose 4-epimerase GalE1 |
| M. abscessus ATCC 19977 | MAB_3779 | - | 3e-14 | 26.76% (355) | dTDP-glucose 4,6-dehydratase RmlB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0550 | galE3 | 7e-38 | 33.23% (334) | UDP-glucose 4-epimerase |
| M. gilvum PYR-GCK | Mflv_1401 | - | 1e-15 | 26.15% (348) | UDP-glucose 4-epimerase |
| M. tuberculosis H37Rv | Rv0536 | galE3 | 7e-38 | 33.23% (334) | UDP-glucose 4-epimerase |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 2e-27 | 28.28% (343) | putative sugar-nucleotide dehydratase |
| M. marinum M | MMAR_0882 | galE3 | 3e-38 | 32.63% (334) | UDP-glucose 4-epimerase, GalE3 |
| M. avium 104 | MAV_3269 | - | 1e-168 | 83.77% (345) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_0386 | - | 1e-157 | 77.87% (348) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_3729 | - | 1e-14 | 26.29% (350) | PUTATIVE UDP-galactose 4-epimerase |
| M. ulcerans Agy99 | MUL_0635 | galE3 | 2e-38 | 32.63% (334) | UDP-glucose 4-epimerase, GalE3 |
| M. vanbaalenii PYR-1 | Mvan_0882 | - | 2e-38 | 32.06% (340) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4111c|M.abscessus_ATCC_199 ------------------------MLISGGAGFIGSALSNRLIQAGYDVA
MAV_3269|M.avium_104 ------------------------MLITGGAGFIGSALSRRLVEAGYDVA
MSMEG_0386|M.smegmatis_MC2_155 MVENQYRFFTTLQANGRRRLLSNTVLITGGAGFIGSALAQRLTHEGYEVA
Mb0550|M.bovis_AF2122/97 ----------------------MRVLLTGAAGFIGSRVDAALRAAGHDVV
Rv0536|M.tuberculosis_H37Rv ----------------------MRVLLTGAAGFIGSRVDAALRAAGHDVV
MMAR_0882|M.marinum_M ----------------------MKVLLTGAAGFIGSRVGAALSAAGHEVV
MUL_0635|M.ulcerans_Agy99 ----------------------MKVLLTGAAGFIGSRVGAALSAAGHEVV
Mvan_0882|M.vanbaalenii_PYR-1 ----------------------MRVLLTGAAGFIGTRIRERLIDGGHDVV
Mflv_1401|M.gilvum_PYR-GCK ----------------------MSWLITGGAGYIGSHVARAMLEAGRDVV
TH_3729|M.thermoresistible__bu ----------------------MTWLVTGGAGYIGSHVVRALLEADLPVV
MLBr_00204|M.leprae_Br4923 -----------------MYGEPVRALVTGAAGFIGSTLVDRLLADGHTVV
*::*.**:**: : : . *.
MAB_4111c|M.abscessus_ATCC_199 VMDVLHPQVHARGRAIDLPASVRLFTGDVTHAPDWDAVLR---LFE-PSQ
MAV_3269|M.avium_104 LMDVLHPQVHGGDRPVELAPSVRLFTGDVTHAPDFDAVLR---LFR-PTQ
MSMEG_0386|M.smegmatis_MC2_155 VMDLLHPQVHARGSKVDLPRSVRLFTGDVTHAPDWDAVLR---LFQ-PAQ
Mb0550|M.bovis_AF2122/97 GVDALLPAAHG-------PNPVLPPGCQRVDVRDASALAP---LLAGVDL
Rv0536|M.tuberculosis_H37Rv GVDALLPAAHG-------PNPVLPPGCQRVDVRDASALAP---LLAGVDL
MMAR_0882|M.marinum_M GVDVLLPAAHG-------PNPVLPPGCHRVDVRDADAMAP---LLAGVDL
MUL_0635|M.ulcerans_Agy99 GVDVLLPAAHG-------PNPVLPPGCHRVDVRDADAMAP---LLAGVDL
Mvan_0882|M.vanbaalenii_PYR-1 AVDAMLPAAHG-------EDAAPPDDVARVDVRDAAAVAD---AVAGVDV
Mflv_1401|M.gilvum_PYR-GCK VIDDLSSGFES-----FVPDGAAFVEGTLLDAALVDDTLA----RFDVDG
TH_3729|M.thermoresistible__bu VIDDLSTGLEK-----FVPSEVPLVRGTLLDADLVARALR----EHRVSG
MLBr_00204|M.leprae_Br4923 GLDNFATGHAA-----NLEHLASTPALAFVEADIVTADLQTILDEHRPEV
:* : . . ..
MAB_4111c|M.abscessus_ATCC_199 VVHLAAETGTAQSLSEATRHGSVNVVGTTQLLDALSRSALVPDQLVLASS
MAV_3269|M.avium_104 IVHLAAETGTAQSLSEATRHGSVNVVGTTQLLDALSRSGLVPEQLVLASS
MSMEG_0386|M.smegmatis_MC2_155 VVHLAAETGTAQSLSEATRHSSVNVVGTTQLLDALSRADLVPDQIVLASS
Mb0550|M.bovis_AF2122/97 VCHQAAMVGAGVNAADAPAYGGHNDFATTVLLAQMFAAGVR--RLVLASS
Rv0536|M.tuberculosis_H37Rv VCHQAAMVGAGVNAADAPAYGGHNDFATTVLLAQMFAAGVR--RLVLASS
MMAR_0882|M.marinum_M VCHQAAMVGAGVDAADAPAYGGHNDLATTVLLAQMFAAGVR--RLVLASS
MUL_0635|M.ulcerans_Agy99 VCHQAAMVGAGVDAADAPAYGGHNDLATTVLLAQMFAAGVR--RLVLASS
Mvan_0882|M.vanbaalenii_PYR-1 VCHQAAVVGAGVDAADAPSYAAHNDFATAVLLAQMFGAGCR--RLVLASS
Mflv_1401|M.gilvum_PYR-GCK VIHIAGYKYAGESVKRPLHTYEQNVSTTVILLQAMEARGVG--QIVFSSS
TH_3729|M.thermoresistible__bu VIHIAGFKYAGVSVQQPLHTYEQNVSAMVTLLKAMQDTGVD--MMVFSSS
MLBr_00204|M.leprae_Br4923 VFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVR--KIVHTSS
: * *. . . . * . * :* :**
MAB_4111c|M.abscessus_ATCC_199 -RAVYGEGAWQSG-AEVFYPRPRSHAQLLAGEWDPQGPAGASATPLSSCA
MAV_3269|M.avium_104 -RAVYGEGAWQSG-AEVFYPQPRSHAQLVAGRWDPQGPAGEQAVPLPSRA
MSMEG_0386|M.smegmatis_MC2_155 -RAVYGEGEWRTATDSTFYPLPRSHAQLAAGRWDPVGPNGEHAVPLPSCA
Mb0550|M.bovis_AF2122/97 -MVVYGQGRYDCPQHGPVDPLPRRRADLDNGVFEHRCPGCGEPVIWQLVD
Rv0536|M.tuberculosis_H37Rv -MVVYGQGRYDCPQHGPVDPLPRRRADLDNGVFEHRCPGCGEPVIWQLVD
MMAR_0882|M.marinum_M -MVVYGQGRYDCPEHGRIDPLPRRHSDLDAGVFEHRCPLCAEPVRWRLVG
MUL_0635|M.ulcerans_Agy99 -MVVYGQGHYDCPEHGRIDPLPRRHSDLDAGVFEHRCPLCAEPVRWRLVG
Mvan_0882|M.vanbaalenii_PYR-1 -MVVYGQGRYVCPGHGDVDPVPRTRSDLDAGAFDHRCPICGEPVDWALVG
Mflv_1401|M.gilvum_PYR-GCK -AATFG------------------------------------TPDVDIVD
TH_3729|M.thermoresistible__bu -AATFG------------------------------------TPDVDLVT
MLBr_00204|M.leprae_Br4923 GGSIYG------------------------------------TPSQYPTP
:* .
MAB_4111c|M.abscessus_ATCC_199 DRTEPRPTNIYAGTKLAQEHLLASWAAAHDTNLSVLRLQNVYGPGQS--L
MAV_3269|M.avium_104 DRTEPRPTNVYAATKLAQEHLLAAWTAAHDTNLSVLRLQNVYGPGQS--L
MSMEG_0386|M.smegmatis_MC2_155 SRTEPRPTNVYAATKLAQEHVLTAWTAAHDTKLSVLRLQNVYGPGQS--L
Mb0550|M.bovis_AF2122/97 EDAPLRPRSLYAASKTAQEHYALAWSEASGGSVVALRYHNVYGPGMP--R
Rv0536|M.tuberculosis_H37Rv EDAPLRPRSLYAASKTAQEHYALAWSEASGGSVVALRYHNVYGPGMP--R
MMAR_0882|M.marinum_M EEAELRPRSLYAASKTAQEHYALAWSESTGGSVVALRYHNVYGPGMP--R
MUL_0635|M.ulcerans_Agy99 EEAELRPRSLYAASKTAQEHYALAWSESTGGSVVALRYHNVYGPGMP--R
Mvan_0882|M.vanbaalenii_PYR-1 EGAPLRPRSLYAASKVAQEHYALAWSESTGGSVVALRYHNVYGPGMP--R
Mflv_1401|M.gilvum_PYR-GCK ESTPTTPESPYGETKLIGEWLLRDAGRASGLRHTSLRYFNVVGSGAVELF
TH_3729|M.thermoresistible__bu ETTPTRPESPYGESKLIGEWLLADVGRATGLRHTSLRYFNVVGSGSPELF
MLBr_00204|M.leprae_Br4923 ETVPTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPANVYGPRQDPYG
. . * . *. * * . : ** *.
MAB_4111c|M.abscessus_ATCC_199 TNSYTGIVTLFARLAREKQALEVYE------DGRIVRDFVFIDDVVDALF
MAV_3269|M.avium_104 TNSYTGIVALFARLARQGQALEVYE------DGRIVRDFVYIDDVVDALF
MSMEG_0386|M.smegmatis_MC2_155 TNSYTGIVALFARLAREQQTLEVYE------DGNILRDFVFIEDVVEALY
Mb0550|M.bovis_AF2122/97 DTPYSGVAAIFRSAVEKGKPPKVFE------DGGQMRDFVHVDDVAAANL
Rv0536|M.tuberculosis_H37Rv DTPYSGVAAIFRSAVEKGKPPKVFE------DGGQMRDFVHVDDVAAANL
MMAR_0882|M.marinum_M DTPYSGVAAIFRSSLEKGEPPKVFE------DGGQMRDFVHVDDIAAANL
MUL_0635|M.ulcerans_Agy99 DTPYSGVAAIFRSSLEKGEPPKVFE------DGGQMRDFVHVDDIAAANL
Mvan_0882|M.vanbaalenii_PYR-1 DTPYSGVAAIFRSALEAGDVPRVFE------DGGQMRDFVHVDDVAAANV
Mflv_1401|M.gilvum_PYR-GCK DASPHNLFPLVFDMLFRGETPRINGDDYPTPDGTCVRDYIHVSDLALAHV
TH_3729|M.thermoresistible__bu DVSPHNLFPLVFDMLYRGETPRINGDDYPTPDGTCVRDYIHVADLALAHV
MLBr_00204|M.leprae_Br4923 EAG---VVAIFVQALLSDRPTKVFG------DGTHTRDYVFVDDVVDAFI
: .:. .: ** **::.: *:. *
MAB_4111c|M.abscessus_ATCC_199 AAVHTP---ATERRTLDIGSGTATTIHELARKVADICAA-PEPVVVGKFR
MAV_3269|M.avium_104 AAVQRP---ASPQRRLDVGSGRATTIQELANTIAAMCEA-PEPVVVGKFR
MSMEG_0386|M.smegmatis_MC2_155 AAIRRP---ADQRRCLDIGSGVGSSIHALAQKVAGICGA-PTPKVVGKFR
Mb0550|M.bovis_AF2122/97 AAVHLGEADRDGFTAVNVCSGRPISILQVATAICDARGGSMSPAITGHYR
Rv0536|M.tuberculosis_H37Rv AAVHLGEADRDGFTAVNVCSGRPISILQVATAICDARGGSMSPAITGHYR
MMAR_0882|M.marinum_M AAAQLGEVDRHGFVAANVCSGRPISILQVASALCQARGDALSPVITGQYR
MUL_0635|M.ulcerans_Agy99 AAAQLGEVDRHGFVAANVCSGRPISILQVASALCQARGDALSPVITGQYR
Mvan_0882|M.vanbaalenii_PYR-1 AAVEAG---TEGFNAFNVCSGKPVSILDVATALCEARGD-VSPLVTGQYR
Mflv_1401|M.gilvum_PYR-GCK AAAQRLAAGEPVEPVYNLGSGAGTSVREIMTAMRTVTGVDFEPVVMPR-R
TH_3729|M.thermoresistible__bu AAARRLQAGEPVEPVYNLGSGSGTSVREIMTAIRKVTGVDFVPEIAPR-R
MLBr_00204|M.leprae_Br4923 KASGDAGGGQ----RFNIGTGIETSDRQLHTAVSAAVGGPDDPEFHPP-R
* :: :* : : : * . *
MAB_4111c|M.abscessus_ATCC_199 DGDVRAASCDIAPAVEGLGWSPKWTLEDGLHALLEWIDKDCPNRF-
MAV_3269|M.avium_104 DGDVRAASCDIEPATSQLGWHPKWTLEDGLRALLEWIG----NRP-
MSMEG_0386|M.smegmatis_MC2_155 DGDVRAASCDIEPARMELDWRPKWTLDDGLPALLDWIAKSDVSH--
Mb0550|M.bovis_AF2122/97 SGDVRHIVADPARAARVLGFRAAVDPGEGLREFAFAPLR-------
Rv0536|M.tuberculosis_H37Rv SGDVRHIVADPARAARVLGFRAAVDPGEGLREFAFAPLR-------
MMAR_0882|M.marinum_M SGDVRHIVADPSRAAEVLGFRAAVEPLEGLRGFAFAPLR-------
MUL_0635|M.ulcerans_Agy99 SGDVRHIVADPSRAAEVLGFRAAVEPLEGLRGFAFAPLR-------
Mvan_0882|M.vanbaalenii_PYR-1 SGDVRHIVADPARAADVLGFRAVVDPADGLCEFATAPLRGPALPS-
Mflv_1401|M.gilvum_PYR-GCK PGDPARIVAAGDLAARDLGWSNRHSLEEMVASAWRARQHAGDAYPR
TH_3729|M.thermoresistible__bu PGDPARIVASGELAARDLGWRMRHTLEDMVKSAWEARQRAGDAYPR
MLBr_00204|M.leprae_Br4923 LGDLKRSCLDIGLATTVLGWSPQVQLDDGVRRTVEYFRAAQRS---
** * *.: : :