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MKLGARSTTGWRATIAVAMSNYIEAGSIIAIATSLGFWQTAFGISNFAVGLLAALSANAFGAAIGAILGG PLCDRFGRKAIYTYDLLVYMAGVLLAACAVNYAMLLAAFIITGIAVGAGVPASWTYIAEQAPSVERAKHV GTAQLAWSVGPLIGFALAAALAPLGLLGSRLIFIHLFVVAGVVWWVRQGLAESQIWTDEAKNETQAETKA VASAVGLRGLRGLFSKRVNITALLFLGGIYLFWNTVAGQAGIFMPRVYDTAGLHSPVAQNLLQVLVWGCT VAATYFGFMRYADRVSQRLLYVGGAALGIVGWIVLVAFTDGGVPTMLAFAVLWGVSAGIGAQAFYSLWAS ELFATPYRASAQGVMFFVVRTMTGVLSYFFPTLLAVTGLTAVGVLLVVLLTIAMLIGAFGAPATRGKTLR EIEVERYGAPVSPTAEDKERTPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0588 | - | - | 100% (443) | putative rhamnose tranport protein, MFS family protein |
| M. smegmatis MC2 155 | MSMEG_2966 | - | 5e-23 | 24.60% (435) | major facilitator family protein transporter |
| M. smegmatis MC2 155 | MSMEG_4078 | - | 3e-19 | 24.00% (425) | metabolite transport protein YaaU |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3364 | sugI | 9e-22 | 26.17% (405) | sugar-transport integral membrane protein SugI |
| M. gilvum PYR-GCK | Mflv_1471 | - | 2e-12 | 23.16% (449) | general substrate transporter |
| M. tuberculosis H37Rv | Rv3331 | sugI | 2e-21 | 26.17% (405) | sugar-transport integral membrane protein SugI |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0365c | - | 2e-21 | 27.39% (398) | sugar-transport integral membrane protein |
| M. marinum M | MMAR_1191 | sugI | 1e-19 | 24.94% (433) | sugar-transport integral membrane protein SugI |
| M. avium 104 | MAV_4306 | - | 1e-16 | 24.26% (441) | transporter, major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_3965 | - | 2e-07 | 29.10% (134) | PUTATIVE drug transporter |
| M. ulcerans Agy99 | MUL_1444 | sugI | 3e-20 | 25.17% (433) | sugar-transport integral membrane protein SugI |
| M. vanbaalenii PYR-1 | Mvan_5300 | - | 3e-12 | 23.44% (448) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1471|M.gilvum_PYR-GCK ------------------------------MSSTGSS---------TGLK
Mvan_5300|M.vanbaalenii_PYR-1 ------------------------------MSTQHDARPDGPPSITTGLK
MMAR_1191|M.marinum_M -----------------------------------------------MQR
MUL_1444|M.ulcerans_Agy99 -----------------------------------------------MQR
MAV_4306|M.avium_104 -------------------------------------------MARGSRR
Mb3364|M.bovis_AF2122/97 MTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQLTRSGRR
Rv3331|M.tuberculosis_H37Rv MTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQLTRSGRR
MAB_0365c|M.abscessus_ATCC_199 -------------------------------------MSLITDLRSTSRL
MSMEG_0588|M.smegmatis_MC2_155 -----------------------------------------MKLGARSTT
TH_3965|M.thermoresistible__bu -----------------------------VTSVDAGRSTMSEVFTAYAPR
Mflv_1471|M.gilvum_PYR-GCK RVVVASMAGTVVEWYEFFLYATAATLVFNKVFFAEGTSEAAGLIAALLTY
Mvan_5300|M.vanbaalenii_PYR-1 RVVVASMAGTVVEWYEFFLYATAATLVFNKVFFAEGTSEAAGLIAALLTY
MMAR_1191|M.marinum_M GILVALTAASVGLIYGYDLSIIAGAQLFITEEFGLSTHQQE------LLT
MUL_1444|M.ulcerans_Agy99 GILVALTAASVGLIYGYDLSIIAGAQLFITEEFGLSTHQQE------LLT
MAV_4306|M.avium_104 GLLVGLTAASVGVIYGYDLSIIAGAQLFVTEDFGLSTRQQE------LLT
Mb3364|M.bovis_AF2122/97 ALLVGLTAASVGVLYGYDLSAIAGALLSLSEEFELTTREQE------LLT
Rv3331|M.tuberculosis_H37Rv ALLVGLTAASVGVLYGYDLSAIAGALLSLSEEFELTTREQE------LLT
MAB_0365c|M.abscessus_ATCC_199 GVMVAVTAAAVGVIYGYDSSNIAGALLFLTEDLHLSTHDQQ------VAA
MSMEG_0588|M.smegmatis_MC2_155 GWRATIAVAMSNYIEAGSIIAIATSLGFWQTAFGISNFAVG----LLAAL
TH_3965|M.thermoresistible__bu SAAANPWHALWAMLIGFFMILVDATIVPVANLEIMADLGADYT-AVIWVT
. . :
Mflv_1471|M.gilvum_PYR-GCK AVGFVARPLGGVVFGHFGDKYGRKKLLQFAILLVGVVTFLMGCLPTYNQI
Mvan_5300|M.vanbaalenii_PYR-1 AVGFVARPLGGVVFGHFGDKYGRKKLLQFAILLVGAVTFLMGCLPTYAQI
MMAR_1191|M.marinum_M TMVVIGQIVGALGAGVLANAIGRKKSVVMLLVAYTMFAVLGSLSVSLP--
MUL_1444|M.ulcerans_Agy99 TMVVIGQIVGALGAGVLANAIGRKKSVVMLLVAYTMFAVLGALSVSLP--
MAV_4306|M.avium_104 TMAVIGQIGGALFAGVLANAIGRRRSVLLILSGYAVFALLAAFSVGLP--
Mb3364|M.bovis_AF2122/97 TTAVLGQIAGALGGGILANAIGRKKSVVLIVAGYAVFALLGATSVSVP--
Rv3331|M.tuberculosis_H37Rv TTAVLGQIAGALGGGILANAIGRKKSVVLIVAGYAVFALLGATSVSVP--
MAB_0365c|M.abscessus_ATCC_199 TAVVIGEIFGALIGGPLSNKIGRKRSMVLVAATFGIFSLLSALAVDLN--
MSMEG_0588|M.smegmatis_MC2_155 SANAFGAAIGAILGGPLCDRFGRKAIYTYDLLVYMAGVLLAACAVNYA--
TH_3965|M.thermoresistible__bu SAYLLAYAVPLLIAGRLGDRFGPRTMYLIGLAIFTAASLWCGLAGTIG--
: .. : * : : * : . .
Mflv_1471|M.gilvum_PYR-GCK GVWAPILLVVLRFVQGFAVGGEWGGAVLLVAEHSPAKERGFWASWPQAAV
Mvan_5300|M.vanbaalenii_PYR-1 GVWAPILLVVLRFMQGFAVGGEWGGAVLLVAEHSPNKERGFWASWPQAAV
MMAR_1191|M.marinum_M ------MLLAARFLLGLAVGVSIVVVPVYVAESAPAAVRGSLLTVYQLTT
MUL_1444|M.ulcerans_Agy99 ------MLLAARFLLGLAVGVSIVVVPVYVAESAPAAVRGSLLTVYQLTT
MAV_4306|M.avium_104 ------MLLTARLLLGLTIGVTVVVVPVYVAESAPTAVRGALLTAYQLAI
Mb3364|M.bovis_AF2122/97 ------MLVVARLLLGVTIGLSVVVVPVYVAESAPAAVRGSLVTAYQLAT
Rv3331|M.tuberculosis_H37Rv ------MLVVARLLLGVTIGLSVVVVPVYVAESAPAAVRGSLVTAYQLAT
MAB_0365c|M.abscessus_ATCC_199 ------TLAAARFLLGLTVGVSVVVVPVFVAESSPTKIRGSMLVLYQLAC
MSMEG_0588|M.smegmatis_MC2_155 ------MLLAAFIITGIAVGAGVPASWTYIAEQAPSVERAKHVGTAQLAW
TH_3965|M.thermoresistible__bu ------MLIAARVLQGLGAALLTPQTLSMITRIFPADRRGVPMGVWGATA
* . .: *. . ::. * *. :
Mflv_1471|M.gilvum_PYR-GCK PVGNMLATVVLLVLTGVLPEAAFMSWGWRI-------AFWLSAVVVLIG-
Mvan_5300|M.vanbaalenii_PYR-1 PVGNMLATVVLLVLTGTLSNDAFLSWGWRV-------AFWLSAVVVLVG-
MMAR_1191|M.marinum_M VSGLIVGYLTGYLLAGTHSWRWMLGLATVP-------AMLLLPLLIRMPD
MUL_1444|M.ulcerans_Agy99 VSGLIVGYLTGYLLAGTHSWRWMLGLATVP-------AMLLLPLLIRMPD
MAV_4306|M.avium_104 VSGLIVGYLSGYLLAGTHSWRWMLGLACVP-------AVLLLPLVFRMPD
Mb3364|M.bovis_AF2122/97 LSGIVVGYLVGYLLAGSHGWRAMFGLAAAP-------ATLLLPLLWRMPD
Rv3331|M.tuberculosis_H37Rv LSGIVVGYLVGYLLAGSHGWRAMFGLAAAP-------ATLLLPLLWRMPD
MAB_0365c|M.abscessus_ATCC_199 VTGIIAGYLIAWALSSTGSWRLMLGLAAVP-------AALVLIALLKLPD
MSMEG_0588|M.smegmatis_MC2_155 SVGPLIGFALAAALAP---------LGLLG-------SRLIFIHLFVVAG
TH_3965|M.thermoresistible__bu GVATLIGPLAGGVLVDGLGWQWIFIVNVPIGIAGLVLGARLMPRLPRQDQ
. : . * . : :
Mflv_1471|M.gilvum_PYR-GCK ----YYIRTKVTDAPIFVAAQEEVERTKAVSYGVVEVL------------
Mvan_5300|M.vanbaalenii_PYR-1 ----YYIRTKVTDAPIFVAAQEEVERVKSVSYGVVEVL------------
MMAR_1191|M.marinum_M TPRWYVMKGRIQEARAALLRVDPAADVEEELAEIGTAL-SEGSG----GV
MUL_1444|M.ulcerans_Agy99 TPRWYVMKGRIQEARAALLRVDPAADVEEELAEIGTAL-SEGSG----GV
MAV_4306|M.avium_104 TARWYLLKGRVDDARRALLRVEPAARVDDELAEIGRAV-SEEAASLPAML
Mb3364|M.bovis_AF2122/97 TARWYLLKGRIADARSALRRIQPEADIDAELADMAAAV-DERGG----GI
Rv3331|M.tuberculosis_H37Rv TARWYLLKGRIADARSALRRIQPEADIDAELADMAAAV-DERGG----GI
MAB_0365c|M.abscessus_ATCC_199 TARWYMMRGDRARAREVLSMVDRDVDIDHELDEIAEALRAEGGGSVRARL
MSMEG_0588|M.smegmatis_MC2_155 VVWWVRQGLAESQIWTDEAKNETQAETKAVASAVGLRG-----------L
TH_3965|M.thermoresistible__bu GFDVLGMVLSAVGLFLIVFALQEAQTHRWAPWIWGTLAGGAGVMAMFVIW
:
Mflv_1471|M.gilvum_PYR-GCK -----KRYPRGVFTAMGLRFAENIMYYLVVTFSIVYLKNHVGADTSDILW
Mvan_5300|M.vanbaalenii_PYR-1 -----KRYPRGVFTAMGLRFAENIMYYLVVTFSIVYLKTHVGADTSDILW
MMAR_1191|M.marinum_M SEMLRPPFLRATIFVITLGFLIQITGINAIIYYSPRIFEAMGFTGDFALL
MUL_1444|M.ulcerans_Agy99 SEMLRPPFLRATIFVITLGFLIQITGINAIIYYSPRIFEAMGFTGDFALL
MAV_4306|M.avium_104 AEMVRSPYRRATVFVVVLGFLIQITGINAIIYYSPRIFEAMGFTGNFALL
Mb3364|M.bovis_AF2122/97 GEMVRRPYLRATLFVIALGFLVQITGINAIIYYSPRLFAAMGFAGYFAML
Rv3331|M.tuberculosis_H37Rv GEMVRRPYLRATLFVIALGFLVQITGINAIIYYSPRLFAAMGFAGYFAML
MAB_0365c|M.abscessus_ATCC_199 REMVTAPYRRATFFVVGLGFFIQITGINAVVYYGPRIFEAMGMSGYFAKL
MSMEG_0588|M.smegmatis_MC2_155 RGLFSKRVNITALLFLGGIYLFWNTVAGQAGIFMPRVYDTAGLHSPVAQN
TH_3965|M.thermoresistible__bu QSANRRHPLVPLQIFADRNFMLANVGVATIGFVVTAMVLPAMFFAQAVCG
: :
Mflv_1471|M.gilvum_PYR-GCK WLLAAHAVH-FLVVPQ-------VGRLSDRFGRRPVYIVGAILAATWGFF
Mvan_5300|M.vanbaalenii_PYR-1 WLLAAHAVH-FLVVPQ-------VGRLADRFGRRPVYIAGAMLAATWGFF
MMAR_1191|M.marinum_M GLPALVQIAGVAAVIT-------SLLLVDRVGRRPILLSGIAIMIVADVA
MUL_1444|M.ulcerans_Agy99 GLPALVQIAGVAAVIT-------SLLLVDRVGRRPILLSGIAIMIVADVA
MAV_4306|M.avium_104 ALPALVQVAGLVAVGT-------ALLLVDRVGRRPILLCGTAMMIVADVV
Mb3364|M.bovis_AF2122/97 ALPAMVQVAGLAAVCA-------SLFLVDRLGRRPILLSGIATMITADAV
Rv3331|M.tuberculosis_H37Rv ALPAMVQVAGLAAVCA-------SLFLVDRLGRRPILLSGIATMITADAV
MAB_0365c|M.abscessus_ATCC_199 GLPALVQVAALLAVFI-------SMSSIDRMGRRPILMIGIGIMIVADAL
MSMEG_0588|M.smegmatis_MC2_155 LLQVLVWGCTVAATYFG------FMRYADRVSQRLLYVGGAALGIVGWIV
TH_3965|M.thermoresistible__bu LSPTGSALLIAPMAVASGVLAPMAGRIVDRSHPTPVVGFGFSVVAVGLTW
. . ** : * .
Mflv_1471|M.gilvum_PYR-GCK AFPMMNT-----GSYLLIMGAVILGLMIHA--------------------
Mvan_5300|M.vanbaalenii_PYR-1 AFPMMNS-----GDYLLILGAVILGLMIHA--------------------
MMAR_1191|M.marinum_M LMAVFAR-----GQGAAILGFAGILLFIIG--------------------
MUL_1444|M.ulcerans_Agy99 LMAVFAR-----GQGAAILGFAGILLFIIG--------------------
MAV_4306|M.avium_104 LVAVFGR-----GPGGVIAGFAGVLLFIFG--------------------
Mb3364|M.bovis_AF2122/97 LITVFANDSD--GGTGLVLGFAGVLLFIIG--------------------
Rv3331|M.tuberculosis_H37Rv LITVFANDSD--GGTGLVLGFAGVLLFIIG--------------------
MAB_0365c|M.abscessus_ATCC_199 LVGVFAVGGSSFGGLLTFLGFLGIVLIAVG--------------------
MSMEG_0588|M.smegmatis_MC2_155 LVAFTDG------GVPTMLAFA--VLWGVS--------------------
TH_3965|M.thermoresistible__bu LAVEMAPTTPIWRLVLPFVAVGVGMAFIWSPLATTATRQLPLHLSGAGSG
. . .
Mflv_1471|M.gilvum_PYR-GCK ---------LMYAP---QPAIMAEMFPTRMRYSGVSLGYQVTSIVAGSLA
Mvan_5300|M.vanbaalenii_PYR-1 ---------LMYAP---QPAIMAEMFPTRMRYSGVSLGYQVTSIVAGSLA
MMAR_1191|M.marinum_M ---------YTMGFGSLGWVYASESFPTRLRSIGSST-MLTANLIANAIV
MUL_1444|M.ulcerans_Agy99 ---------YTMGFGSLGWVYASESFPTRLRSIGSST-MLTANLIANAIV
MAV_4306|M.avium_104 ---------YTMGFGSLGWVYASESFPSRLRSIGSST-MLTSNLVANAIV
Mb3364|M.bovis_AF2122/97 ---------FNFGFGSLVWVYAAESFPSRLRSMGSSL-MLTSTLTANAIV
Rv3331|M.tuberculosis_H37Rv ---------FNFGFGSLVWVYAAESFPSRLRSMGSSP-MLTSTLTANAIV
MAB_0365c|M.abscessus_ATCC_199 ---------FTFGFGSLVWVYAGESFPARLRSYGASA-MLTSDLVANAVV
MSMEG_0588|M.smegmatis_MC2_155 ---------AGIGAQAFYSLWASELFATPYRASAQGVMFFVVRTMTG-VL
TH_3965|M.thermoresistible__bu VYNTTRQIGSVLGSAGMAAFLTGRLSAELPFGATAVPAGEQTRVLPEFLH
. .. . . :
Mflv_1471|M.gilvum_PYR-GCK PAIATWLLDKFGTWVPIALYLAGAAVITL--VAAWFTRETKGIDLHALDV
Mvan_5300|M.vanbaalenii_PYR-1 PAIATWLLDRFGTWVPIAVYLAGAAVITL--VAAWFTRETNGIDLHSLDV
MMAR_1191|M.marinum_M AGVFLTMLHSLGGSGAFAVFGVLALVAFG--VVYRYAPETKGRQLEEIRH
MUL_1444|M.ulcerans_Agy99 AAVFLTMLHSLGGSGAFAVFGVLALVAFG--VVYRYAPETKGRQLEEIRH
MAV_4306|M.avium_104 AAVFLTLLHSLGGAGTFAVFAVLAVVAFA--FVHRYAPETKGRQLEDIRH
Mb3364|M.bovis_AF2122/97 AAFSLTMLRVLGGAGVFAVFGTFAVVAFV--VVYRFAPETKGRKLEEIRH
Rv3331|M.tuberculosis_H37Rv AAFSLTMLRVLGGAGVFAVFGTFAVVAFV--VVYRFAPETKGRKLEEIRH
MAB_0365c|M.abscessus_ATCC_199 SMYFLTLLTALGGVVAFGVFGVLATAALV--FVHVLAPETKGRNLEEIRH
MSMEG_0588|M.smegmatis_MC2_155 SYFFPTLLAVTGLTAVGVLLVVLLTIAML--IGAFGAPATRGKTLREIEV
TH_3965|M.thermoresistible__bu APYAAAMAQSMLLPAFVALFGVLAAIFLAGIVLSTPQPDADAQYLDEHDD
. : : . . : . *
Mflv_1471|M.gilvum_PYR-GCK ADREQLEKAGIV--------------------------------------
Mvan_5300|M.vanbaalenii_PYR-1 ADREQLAKAGIV--------------------------------------
MMAR_1191|M.marinum_M FWENGGRWPEKLTEAP----------------------------------
MUL_1444|M.ulcerans_Agy99 FWENGGRWPEKLTEAP----------------------------------
MAV_4306|M.avium_104 FWENGGRWD-----------------------------------------
Mb3364|M.bovis_AF2122/97 FWENGGRWPAERSPAADEP-------------------------------
Rv3331|M.tuberculosis_H37Rv FWENGGRWPAERSPAADEP-------------------------------
MAB_0365c|M.abscessus_ATCC_199 FWESGGTWPET---------------------------------------
MSMEG_0588|M.smegmatis_MC2_155 ERYGAPVSPTAEDKERTPA-------------------------------
TH_3965|M.thermoresistible__bu YLVIELARPDPNPRTDIAVTAVIPALRPTLRPTLRPSLGPPGGPVVQPNN
Mflv_1471|M.gilvum_PYR-GCK -----
Mvan_5300|M.vanbaalenii_PYR-1 -----
MMAR_1191|M.marinum_M -----
MUL_1444|M.ulcerans_Agy99 -----
MAV_4306|M.avium_104 -----
Mb3364|M.bovis_AF2122/97 -----
Rv3331|M.tuberculosis_H37Rv -----
MAB_0365c|M.abscessus_ATCC_199 -----
MSMEG_0588|M.smegmatis_MC2_155 -----
TH_3965|M.thermoresistible__bu TAALR