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LEQDMTDEEFEPYFAKAQEVSQFFREIGPKYDQENTFAYPSIEAFKKSGLGALPVPRAFGGPGGNILHVS KVVTELSRGDSAITLAYNMHYIMLGIAGNLMSEEQNKYWMGRVIDGELIFGPFSEQRAGFSGLADMKAVP QPGGGWRLYGKKTWGTLCEAASIITTNATETDANGNLPETFEERVAAEKLFIGDFTVDENGAGDGIRIEK TWDALGMHATGTQTIVFDGYFVPEDGFVSVWRAGAFGTLEWASLMFASIYLGMQQRILEEATNALAKKHL GATFGAIVAEDTAVKDVGHIVDGIGDFASRVEWSRRVLHRTCEDLLEGRDKEWPAELRFPYLGLAKTFIA DNVLHMSRHAMSMIGGSAFRKGTIFERLYRDSAASMFQPLNADQTRTYVGQYLLEQAAAK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0323 | - | - | 100% (411) | acyl-CoA dehydrogenase, short-chain specific, putative |
| M. smegmatis MC2 155 | MSMEG_2650 | - | 3e-16 | 25.61% (289) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0108 | - | 3e-13 | 22.98% (383) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2528c | fadE19 | 3e-14 | 21.37% (365) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4943 | - | 5e-14 | 22.05% (381) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv2500c | fadE19 | 3e-14 | 21.37% (365) | acyl-CoA dehydrogenase |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-11 | 22.83% (368) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4538c | - | 4e-14 | 23.58% (369) | putative acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3847 | fadE19 | 2e-15 | 22.59% (363) | acyl-CoA dehydrogenase FadE19 |
| M. avium 104 | MAV_1672 | - | 9e-15 | 23.42% (363) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3384 | - | 8e-15 | 24.47% (376) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3778 | fadE19 | 6e-15 | 22.31% (363) | acyl-CoA dehydrogenase FadE19 |
| M. vanbaalenii PYR-1 | Mvan_0356 | - | 0.0 | 86.13% (411) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3847|M.marinum_M ------------MTTAISAGTLPKEYQDLRDTVADFARSVVAPVSAKHDE
MUL_3778|M.ulcerans_Agy99 ------------MTTAISAGTLPKEYQDLRDTVADFARSVVAPVSAKHDE
MAV_1672|M.avium_104 ------------MTTSITAGTLPKEYQDLRDTVAEFARTVVAPVSAKHDE
Mb2528c|M.bovis_AF2122/97 ---------MTTTTTTISGGILPKEYQDLRDTVADFARTVVAPVSAKHDA
Rv2500c|M.tuberculosis_H37Rv ---------MTTTTTTISGGILPKEYQDLRDTVADFARTVVAPVSAKHDA
MAB_4538c|M.abscessus_ATCC_199 --------------MTFSTAELPDEYESLRKTVEEFAHSVVAPAAAHHDA
Mflv_4943|M.gilvum_PYR-GCK -------MP-------VDRLLPTDDARDLVELARQIADKVLDPIVDRHEK
MLBr_00737|M.leprae_Br4923 -------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQ
TH_3384|M.thermoresistible__bu -------MTR-----LAQTLGLTEFQTEILRTVREFVDREIIPNAAEFER
MSMEG_0323|M.smegmatis_MC2_155 ----------------MLEQDMTDEEFEPYFAKAQEVSQFFREIGPKYDQ
Mvan_0356|M.vanbaalenii_PYR-1 MTGSIGTNRSTIKGVTMLEQDLTDEDFAPYFVKAQEVSQFFREIGPKYDQ
.. . . :
MMAR_3847|M.marinum_M EHSFPYEVVAKMGEMGLFGLPFPEEYGGMGGDYFALALALEELGKVDQSV
MUL_3778|M.ulcerans_Agy99 EHSFPYEVVAKMGEMGLFGLPFPEEYGGMGGDYFALALALEELGKVNQSV
MAV_1672|M.avium_104 EHSFPYEVVAKMGEMGLFGLPFPEEYGGMGGDYFALSLALEELGKVDQSV
Mb2528c|M.bovis_AF2122/97 EHSFPYEIVAKMGEMGLFGLPFPEEYGGMGGDYFALSLVLEELGKVDQSV
Rv2500c|M.tuberculosis_H37Rv EHSFPYEIVAKMGEMGLFGLPFPEEYGGMGGDYFALSLVLEELGKVDQSV
MAB_4538c|M.abscessus_ATCC_199 TKTFPYAVVAQMGEMGLFGLPFPEEYGGMGGDYFALCLTLEELARADQSV
Mflv_4943|M.gilvum_PYR-GCK DETYPEGVFATLGEAGLLSLPYPEEWGGGGQPYEVYLQVLEELAARWAAV
MLBr_00737|M.leprae_Br4923 RARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASA
TH_3384|M.thermoresistible__bu TDTYPQPIVDQMREMGLFGLMIPEEYGGLGESLLTYALCVEELARGWMSI
MSMEG_0323|M.smegmatis_MC2_155 ENTFAYPSIEAFKKSGLGALPVPRAFGGPGGNILHVSKVVTELSRGDSAI
Mvan_0356|M.vanbaalenii_PYR-1 ENTFAYPSIEVFKKSGLGALPVPKAFGGPGGNILQVSKVVSELSKGDSAI
:. . : *: .: *. :** * : *:. :
MMAR_3847|M.marinum_M AITLEAGVGLGAMPIYRFGNEEQKSKWLPDLLAGRALAGFGLTEPGAGSD
MUL_3778|M.ulcerans_Agy99 AITLEAGVGLGAMPIYRFGNEEQKSKWLPDLLAGRALAGFGLTEPGAGSD
MAV_1672|M.avium_104 AITLEAGVSLGAMPIYRFGNEEQKRKWLPDLTAGRALAGFGLTEPGAGSD
Mb2528c|M.bovis_AF2122/97 AITLEAAVGLGAMPIYRFGTEEQKQKWLPDLTSGRALAGFGLTEPGAGSD
Rv2500c|M.tuberculosis_H37Rv AITLEAAVGLGAMPIYRFGTEEQKQKWLPDLTSGRALAGFGLTEPGAGSD
MAB_4538c|M.abscessus_ATCC_199 AITLEAAVSLGAMPVYRYGSEEQKQRWLPELASGKSLAAFGLTEPGGGTD
Mflv_4943|M.gilvum_PYR-GCK AVAVSVHS-LSCHPLMSFGSDEQRQRWLPDMLGGSTIGAYSLSEPQAGSD
MLBr_00737|M.leprae_Br4923 SLIPAVNK-LGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSD
TH_3384|M.thermoresistible__bu SGVINTHF-IVAYMIRQHGTEEQKQRFLPRMATGETRGAFSMSEPELGSD
MSMEG_0323|M.smegmatis_MC2_155 TLAYNMHYIMLGIAGNLMS-EEQNKYWMGRVIDGELIFGP-FSEQRAGFS
Mvan_0356|M.vanbaalenii_PYR-1 TLAYNMHYIMVGIAGNLMS-EEQNKYWLGRVADGELMFGP-FSEQRAGFS
: : . :* . : : . ::* * .
MMAR_3847|M.marinum_M A-GSTRTTARLDGGEWVVNGSKQFITNSGTDITSLVTITAVTG-------
MUL_3778|M.ulcerans_Agy99 A-GSTRTTARLDGGEWVVNGSKQFITNSGTDITSLVTITAVTG-------
MAV_1672|M.avium_104 A-GATRTTARLEDGEWVINGSKQFITNSGTDITSLVTVTAVTG-------
Mb2528c|M.bovis_AF2122/97 A-GSTRTTARLEGDEWIINGSKQFITNSGTDITSLVTVTAVTGT------
Rv2500c|M.tuberculosis_H37Rv A-GSTRTTARLEGDEWIINGSKQFITNSGTDITSLVTVTAVTGT------
MAB_4538c|M.abscessus_ATCC_199 IPGSIRTRAVEDNGSWVINGAKAFITNSGTDITAVVGVAAVTG-------
Mflv_4943|M.gilvum_PYR-GCK AAALTCRATAVDGG-YRITGSKAWITHGGIADFYNLFARTG---------
MLBr_00737|M.leprae_Br4923 AASMRTRAKADGDD-WILNGFKCWITNGGKSTWYTVMAVTDP--------
TH_3384|M.thermoresistible__bu VAAIRTRATRNGDGTYTIDGQKMWLTNGATSTLVAVLVRTDEG-------
MSMEG_0323|M.smegmatis_MC2_155 G-LADMKAVPQPGGGWRLYGKKTWGTLCEAASIITTNATETDANGNLPET
Mvan_0356|M.vanbaalenii_PYR-1 G-LADMQAVPQKDGGWKLYGKKTWGTLCEAADIITTNATETDADGNLPDT
.. : : * * : *
MMAR_3847|M.marinum_M ---SIADGKKEISTIIVPSGT------PGFIVEPVYNKVGWNASDTHPLS
MUL_3778|M.ulcerans_Agy99 ---SIADGKKEISTIIVPSGT------PGFIVEPVYNKVGWNASDTHPLS
MAV_1672|M.avium_104 ---TVGADKKEISTIIVPSGT------PGFTVEPVYSKVGWNASDTHPLS
Mb2528c|M.bovis_AF2122/97 -TGTAADAKKEISTIIVPSGT------PGFTVEPVYNKVGWNASDTHPLT
Rv2500c|M.tuberculosis_H37Rv -TGTAADAKKEISTIIVPSGT------PGFTVEPVYNKVGWNASDTHPLT
MAB_4538c|M.abscessus_ATCC_199 ---RSADGSPEISVIHVPSGT------PGFTVEPGYDKVGWHASDTHPLS
Mflv_4943|M.gilvum_PYR-GCK ------EGSQGISCFLVPRDT------EGLTFGKPEEKMGLHAVPTTAAH
MLBr_00737|M.leprae_Br4923 -----DKGANGISAFIVHKDD------EGFSIGPKEKKLGIKGSPTTELY
TH_3384|M.thermoresistible__bu ----ADKPHRNLTTFLIEKPTGFGEVAPGLTIPGKIDKLGYKGIDTTELI
MSMEG_0323|M.smegmatis_MC2_155 FEERVAAEKLFIGDFTVDENGAG----DGIRIEKTWDALGMHATGTQTIV
Mvan_0356|M.vanbaalenii_PYR-1 FDGRVAAEKLFIGDFKVDENGVG----DGIRIEKTWDALGMHATGTQTIV
: : : *: . . :* :. *
MMAR_3847|M.marinum_M FDDARVPEENLLGI-RGKGYANFLSILDEGRIAIAALATGVAQGCVDESV
MUL_3778|M.ulcerans_Agy99 FDDARVPEENLLGI-RGKGYANFLSILDEGRIAIAALATGVAQGCVDESV
MAV_1672|M.avium_104 FSDARVPEENLLGA-RGTGYANFLSILDEGRIAIAALATGAAQGCVDESV
Mb2528c|M.bovis_AF2122/97 FADARVPRENLLGA-RGSGYANFLSILDEGRIAIAALATGAAQGCVDESV
Rv2500c|M.tuberculosis_H37Rv FADARVPRENLLGA-RGSGYANFLSILDEGRIAIAALATGAAQGCVDESV
MAB_4538c|M.abscessus_ATCC_199 FDDVRVPYENLLGE-RGRGYAGFLRILDEGRIAIAAVATGAAQGCVDESL
Mflv_4943|M.gilvum_PYR-GCK YDDANLDSDRRIGT-EGQGLQIAFSALDSGRLGIAAVAVGLAQAALDEAV
MLBr_00737|M.leprae_Br4923 FDKCRIPGDRIIGE-PGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAI
TH_3384|M.thermoresistible__bu FDGYRADAGDILGERPGQGFFQMMDGVEVGRVNVSARACGVGIRAFELAV
MSMEG_0323|M.smegmatis_MC2_155 FDGYFVPEDGFVSVWRAGAFG----TLEWASLMFASIYLGMQQRILEEAT
Mvan_0356|M.vanbaalenii_PYR-1 FDGYFVPEDGFVSVWRAGAFG----VLEWASLMFASIYLGMQQRILEESV
: :. . . :: ..: * .: :
MMAR_3847|M.marinum_M KYAKERQS---FGQPIGSYQAISFK------IARMEARAHVARTAYYEAA
MUL_3778|M.ulcerans_Agy99 KYAKERQS---FGQPIGSYQAISFK------IARMEARAHVARTAYYEAA
MAV_1672|M.avium_104 KYAKERQS---FGQPIGSYQAISFK------IARMEARAHVARTAYYDAA
Mb2528c|M.bovis_AF2122/97 KYANQRQS---FGQPIGAYQAIGFK------IARMEARAHVARTAYYDAA
Rv2500c|M.tuberculosis_H37Rv KYANQRQS---FGQPIGAYQAIGFK------IARMEARAHVARTAYYDAA
MAB_4538c|M.abscessus_ATCC_199 RYARSRPA---FGSAIIDYQSVSFK------IARMQARAHTARLAYYHAA
Mflv_4943|M.gilvum_PYR-GCK AYSQERTT---FGRKIIDHQGLAFL------LADMAAAVDSARATYLDAA
MLBr_00737|M.leprae_Br4923 VYTKDRKQ---FGESISTFQSIQFM------LADMAMKVEAARLIVYAAA
TH_3384|M.thermoresistible__bu RYAQQRHT---FGKPIAEHQAIAFQ------LAEMATKVEAAHLMMVNAA
MSMEG_0323|M.smegmatis_MC2_155 NALAKKHLGATFGAIVAEDTAVKDVGHIVDGIGDFASRVEWSRRVLHRTC
Mvan_0356|M.vanbaalenii_PYR-1 KSLSKKHLGATFGAIVAADTEVKSVGHIIDGIGDMASRVECSRRVLYQTC
.: ** : : :. : .. :: :.
MMAR_3847|M.marinum_M AKMLAGKP-------FKKEAAIAKMISSEAAMDNARDATQVHGGYGFMNE
MUL_3778|M.ulcerans_Agy99 AKMLAGKP-------FKKEAAIAKMISSEAAMDNARDAAQVHGGYGFMNE
MAV_1672|M.avium_104 AKMLAGKP-------FKKEAAIAKMIASEAAMDNARDATQIHGGYGFMNE
Mb2528c|M.bovis_AF2122/97 AKMLAGKP-------FKKEAAIAKMISSEAAMDNSRDATQIHGGYGFMNE
Rv2500c|M.tuberculosis_H37Rv AKMLAGKP-------FKKEAAIAKMISSEAAMDNSRDATQIHGGYGFMNE
MAB_4538c|M.abscessus_ATCC_199 ALLLAGKP-------FKTEASIAKLIASEAAMDNARDATQIFGGAGFMNE
Mflv_4943|M.gilvum_PYR-GCK RRRDAGLP-------YSRHASVAKLVATDAAMKVTTDAVQVLGGAGYTRD
MLBr_00737|M.leprae_Br4923 ARAERGEPD------LGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSD
TH_3384|M.thermoresistible__bu RLKDSGER-------NDVAAGMAKYLASEFCAEVTEQSFRIHGGYGYSKE
MSMEG_0323|M.smegmatis_MC2_155 EDLLEGRDKEWPAELRFPYLGLAKTFIADNVLHMSRHAMSMIGGSAFRKG
Mvan_0356|M.vanbaalenii_PYR-1 QDLLDGKDKLWAPELRFPYLGLAKTFIAGNVMHMSRQAMSMVGGQSFRRG
* . :* . : . : .: : ** .:
MMAR_3847|M.marinum_M YPVARHYRDSKILEIGEGTTEVQLMLIARSLGLS---------
MUL_3778|M.ulcerans_Agy99 YPVARHYRDSKILEIGEGTTEVQLMLIARSLGLS---------
MAV_1672|M.avium_104 YPVARHYRDSKILEIGEGTTEVQLMLIARSLGLS---------
Mb2528c|M.bovis_AF2122/97 YPVARHYRDSKVLEIGEGTTEVQLMLIARSLGLQ---------
Rv2500c|M.tuberculosis_H37Rv YPVARHYRDSKVLEIGEGTTEVQLMLIARSLGLQ---------
MAB_4538c|M.abscessus_ATCC_199 SPVARQYRDSKILEIGEGTSEVQLMLIARALTG----------
Mflv_4943|M.gilvum_PYR-GCK YRVERYMREAKITQIFEGTNQIQRLVISRHLTRG---------
MLBr_00737|M.leprae_Br4923 FPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----------
TH_3384|M.thermoresistible__bu YEIERLMRDAPFLLIGEGTSEIQKNIISKRLLADYRI------
MSMEG_0323|M.smegmatis_MC2_155 TIFERLYRDSAASMFQPLNADQTRTYVGQYLLEQAAAK-----
Mvan_0356|M.vanbaalenii_PYR-1 GIFERLYRDSAASMFQPLNGDQTRTYIGQFLLESAAAQNGASS
. * *:: : . : :.: *