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SFVWVSPELVSAAAADVAGIGSAVGAANTAAAAATTELLAAGGDEVSAAIAELFGMYGRDYQRIAVEAAG FHARVAALLGAGADSYGWAESSGVLSLQGLQRDVWGMVNAPTQMLLGRPLIGDGADGGTVGGVGQSGGAG GLLWGNGGAGGVSTNPGAVGGAGGSAGLIGAGGAGGRGGAGGGGGVGGSGGWLAGVGGAGGAGGVGAIGG AGGSAGLFGGGGSGGAGGAGDVGVAGGAGGVGGRGGWVFGDGGSGGVGGSGGVGVVGGVGGVGGGTGVFG GGGAGGAGGVGGGTGGSGGNGGWLIGAGGIGGDGGAGFAGLPGGFAGGDGGAGGFGGGGGLFGEGGAGGA GGVGGAGTSGGDAVVPGGVGGVGGSGGAGGAGGSGGGAGWLGTAGDGGVGGVGGGGGGGGVGASGVGHQL AGGAGGAGGAGGAAGAGGAAGQGRGGTVGAAGVGGTGGVGGDGGAGDSGAAASAPGGAGGTGWAGGAGGA GGAGGAAAAGGTAGVGGAGGDGGAGGVGAEGAAGAGVVGGGAGGDGGAGGAAGAGGSGGGGIGGGKAGTG GDGGIGGAGGTGGGGGNGDTYSTGGAGGDGGAGGAAGSAGGAGAGSGGAAGSAGSGGSGGDGGAGGASGR ELGSNLGYAGGVGGDGGQGGQGGAAVGGLAGAAGSGGNGGAGGAGGASAVALVGGAGGAGGAGGQGGTAG DGPGGVGGHGGSGGSGGIGGTGGDGYQSGDVGGQGGEGGAGGAAGAGGEAGAQGLAGAGGTGGTGGQGGT GGIGAQGSNGHGVGGRPGTAGAVGGAGGAGGQGGAAGLDGTAGDGGVGGTGGRGGAGGDGAGGVGHQLAG GAGGDGGAGGAAGVGGAAGAGSGGVVGAAGTGGTGGAGGNGGAGDTGVAASTPGDPGGVGFAGGAGGAGG AGGASGVGGVNGVGGAGGDGGTGGAGGAGAGGDRTDGGRGGVGGAGGDAGAGGVTGAGGSGGGVGNAGVG GAGGVGGAGGAGGAADGPGLFGYDGGAGGAGGIGGAAGVGGSNGAGGTGGAGGVGGVGADSGLASRPGGA GGAGGTGGAGGGAGSGAGGLGAGGDGGTGGAGGAGGVGSSAGWGSGLAGQVGGAGGVGGAGGDSGGLGGT NGDGGAGGLGGRGGAGGSSTTVAGAGGGGGRGGDGGSAGGGVGGGGVGGAAGSGGAGGAGGRGIDSYAAA GGRGGDGGAGGIGGGGGLSGIGGAGGQGGSGGAAGTGGDVGGSPGEVGGAGGGGGFGGAGGAGGVGGGAG GSGGVGGSGGNGGLGVATGGAGGVGGQGGAAGAGGAAGAGATAAGAGGVGGLGGDGGNGGNGVRGAAGVA GGDGAVGGGGGAGGAGGQGGAGVTGGSAGAGGQGGNGGLGGPGGDGGSAVRYQRVGGAGGVGGVGGAAGA GGAAGQGGGGAVGAAGVGGTGGVGGNGGAGDAGVAGADGGGAGGSGWAGGAGGAGGQGGAANGGVAGDGG VGGNGGVGGVGGRGGDGANGAPGGGIDGTGRPGGAGGQGGSGGRAGFGGAAGAGEGGEYGAAGVGGNGGD GGAGGRGGYGTTGSGGLFGGSGGHGGVGGIGGNGGSAAAGGVNGNGGNGGIGGNAGDAGNGANGSLLHHA GDGGNGGRGGAGGAGGFAGDGEGSGGTAGSGGNGGKGGNAGAGGNGVPAAGAAAGNGGLGGSGGAGGSGA IGAAAGGAGGAGGNGGTGGNAGIGVMRGASTPALAGDGGVGGAGGLGGVARSVGGVGGVGGDGGSGGTGG IGTTGNSATNGYGGAGGAGGAGGVGGNGGFAALGTGGAAGSGGGGGTGGAGGVSDSPTTSRSVGGAGGVG GVGGNGGIGGNGQIGGDGGSGGAAGAGGAGAQNLTRSIQSANFGGAGGAGGVGGFGGVGGTGASGLGGSG GIGGDGGAGGVGGDCSVPLSPGNGGDGGAGGDGGDGGDGGNGQPGGPGGAGGGAASGGAGGYGQLGNGAA GADGNNGTPGADG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_4316 | - | - | 100% (1974) | PE-PGRS family protein |
M. marinum M | MMAR_5294 | - | 0.0 | 52.86% (2274) | PE-PGRS family protein |
M. marinum M | MMAR_1594 | - | 0.0 | 50.13% (2248) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3541 | PE_PGRS55 | 0.0 | 51.63% (1999) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 50.88% (792) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 0.0 | 51.17% (1966) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01556 | infB | 5e-10 | 44.68% (94) | translation initiation factor IF-2 |
M. abscessus ATCC 19977 | MAB_4284c | - | 9e-59 | 34.14% (577) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 3e-25 | 42.53% (174) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-172 | 41.17% (1093) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 3e-45 | 40.64% (342) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 53.10% (1130) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 0.0 | 49.94% (791) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_4316|M.marinum_M --------------------------------MSFVWVSPELVSAAAAD- MUL_4367|M.ulcerans_Agy99 --------------------------------MSFVSVGPGLLEAAARD- Rv3508|M.tuberculosis_H37Rv --------------------------------MSFVLIAPEFVTAAAGD- Mb3541|M.bovis_AF2122/97 --------------------------------MSFVLISPEVVSAAAGD- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP MAV_4827|M.avium_104 -----------------------------MNIVLGVSMAPSSIQMVVLEG MLBr_01556|M.leprae_Br4923 ------------------------------MAGKARVHELAKELGVTSKE Mflv_5091|M.gilvum_PYR-GCK -----------------------------------MVTFGGGA------- Mvan_1264|M.vanbaalenii_PYR-1 ----MMFLAPPGGPGPISAAIQLTSTGSEATEPWYVVSFGGSG------- MMAR_4316|M.marinum_M -VAGIGSAVGAANTAAAAATTELLAAGGDEVSAAIAELFGMYGRDYQR-- MUL_4367|M.ulcerans_Agy99 -LAGLGAGLREANLAAAGATVGVLPAAGDEVSAAIAELFGGFGREYQA-- Rv3508|M.tuberculosis_H37Rv -LTNLGSSISAANASAASATTQVLAAGADEVSARIAALFGGFGLEYQA-- Mb3541|M.bovis_AF2122/97 -LANVGSTISAANKAAAAATTQVLAAGADEVSARIAALFGMYGLEYQA-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VEAASYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVN MAV_4827|M.avium_104 EYADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQLS- MLBr_01556|M.leprae_Br4923 VLARLNEQGEFVKSASSTVEAPVARRLRESFGGIKPAADKGAEQVATKAQ Mflv_5091|M.gilvum_PYR-GCK ----TPTPTSLGAAAVDLSGTSCG-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----APTPNNLAASLVDLSGTSCG-------------------------- MMAR_4316|M.marinum_M ---IAVEAAGFHARVAALLGAGADSYGWAESSGVLSLQGLQRDVWGMVNA MUL_4367|M.ulcerans_Agy99 ---MGARVALLHDDFVRALTAGGSAYGQAEALNMWPLQELEQQALGVVNA Rv3508|M.tuberculosis_H37Rv ---ISAQVAAYHQRFVQALSTGAGAYASAEAA------AAEQIVLGVINA Mb3541|M.bovis_AF2122/97 ---ISAQVAAYHQQFVQTLRTGAASYMLAEATN------VEQNLLNLINA MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TGNPIHDLSGNLQNYYAAQPDGPS-------------------------- MAV_4827|M.avium_104 ----SIGVTWTDQLEAAALRDALAARRIDN-------------------- MLBr_01556|M.leprae_Br4923 AKRLGESLDQTLDRALDKAVAGNGATTAAP-------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_4316|M.marinum_M PTQ----------------------------------------------- MUL_4367|M.ulcerans_Agy99 PSM----------------------------------------------- Rv3508|M.tuberculosis_H37Rv PTQ----------------------------------------------- Mb3541|M.bovis_AF2122/97 PTQ----------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------LICNGQDG-- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------LICNGQDG-- MMAR_4316|M.marinum_M ----------------------------------MLLGRPLIGDGADGGT MUL_4367|M.ulcerans_Agy99 ----------------------------------ALFGRPSIGNGVDG-- Rv3508|M.tuberculosis_H37Rv ----------------------------------ALLGRPLIGDGANATT Mb3541|M.bovis_AF2122/97 ----------------------------------TLLGRPLIGDGANATT MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------------------ILSPSLLSPRDNDFL MAV_4827|M.avium_104 ----------------------------------VMLVSAFLAAAALAQN MLBr_01556|M.leprae_Br4923 --------------------------------------VQVDHSAAVVPI Mflv_5091|M.gilvum_PYR-GCK ---TG---QNGGILFGNGGSG----------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---TG---QNGGILFGNGGSG----------------------------- MMAR_4316|M.marinum_M VGGVGQSGGAGGLLWGNGGAGGVSTNPGAVGGAGGSAGLIGAGGAGGRGG MUL_4367|M.ulcerans_Agy99 VAGTGQAGGAGGILWGNGGNG----------------------------- Rv3508|M.tuberculosis_H37Rv PGGAG---GAGGLLFGNGGAG----------------------------- Mb3541|M.bovis_AF2122/97 PGGAG---GDGGLLFGSGGNGAPG-APGQAGGAGGSAGLLGNGGSGGAGG MSMEG_0868|M.smegmatis_MC2_155 DNPNG---GTGGLLFGDGGHG----------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SHNDTDFASHNPIASGNQVMS----------------------------- MAV_4827|M.avium_104 VGGAMGYERTAVLLVEPDTAT----------------------------- MLBr_01556|M.leprae_Br4923 VAGEGPSTAHREELAPPAGQP----------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------WNSDVVG-MDGGNGGNGGLFGGNGGNGGNG Mvan_1264|M.vanbaalenii_PYR-1 --------------------WNSEIAG-VSGGNGGNAGLFGGNGGNGGNG MMAR_4316|M.marinum_M AGGGGGVGGSGGWLAGVGGAGGAGGVG-AIGGAGGSAGLFG-GGGSGGAG MUL_4367|M.ulcerans_Agy99 ---------------------GLGAAG-ANGGAGGSAGLIG-TGGVGGAG Rv3508|M.tuberculosis_H37Rv ---------------------AAGAPG-QAGGPGGPAGLWG-NGGPGGAG Mb3541|M.bovis_AF2122/97 TGAPGGNGGNAGWLYGRGGVGGAGGIGGGTGGAGGHAWLFG-HGGTGGIG MSMEG_0868|M.smegmatis_MC2_155 --------------------YDGSAAG-LAGGNGGNAGLFG-NGGNGGVG TH_3810|M.thermoresistible__bu ------------------------VDG--DGGSGGRTGLFS-KLSRGGDG MAB_4284c|M.abscessus_ATCC_199 ------------------------PSG--NVDSFNRGPLLDLSFGDLQFG MAV_4827|M.avium_104 -------------------------LAVVETSDGSIPDVYKQQIRAESYG MLBr_01556|M.leprae_Br4923 ----------------------SEQPGVPLPGQQGTPAAPHPGHPGMPTG . . . * Mflv_5091|M.gilvum_PYR-GCK ---------------------LGGGNGGNGGNAG-AFALFGNGG------ Mvan_1264|M.vanbaalenii_PYR-1 ---------------------LGSGDGGNGGDAG-LFSLFGRGG------ MMAR_4316|M.marinum_M ---------------GAGDVGVAGGAGGVGGRGGWVFGDGGSGGVGGSGG MUL_4367|M.ulcerans_Agy99 ---------------GVGAAGMTGGSGGAGGGGGWLWGAGGSGGAAG--- Rv3508|M.tuberculosis_H37Rv ---------------GSG-----GGTGGAGGAGGWLFGVGGAGGVGGAGG Mb3541|M.bovis_AF2122/97 GGPGGNGGWLLGNGGHGGAGGIGGGSGGAGGNGGWLLGNGGIGGAGGTGG MSMEG_0868|M.smegmatis_MC2_155 ---------------------WAGLDGGNGGSGGLLMGIGGAGGAGG--- TH_3810|M.thermoresistible__bu ------------------------GDGGLGGNGG---------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------NRDTTAIGDGAVAVGGSNSGPIAS--- MAV_4827|M.avium_104 -----------------------DAAGQLSAMVAGLEKLESLPG------ MLBr_01556|M.leprae_Br4923 -----------------------PHPGPAPKPGGRPPRVGNNPFSSAQSV . Mflv_5091|M.gilvum_PYR-GCK -------------------------------NGGNGGVG----------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------NGGNGGVG----------- MMAR_4316|M.marinum_M VGVVGGVGGVGGGTGVFGGGGAGGAGGVGGGTGGSGGNGGWLIGAGGIGG MUL_4367|M.ulcerans_Agy99 -------------------------------AGGSGGSGGWLWGN----- Rv3508|M.tuberculosis_H37Rv ----GTGGAGGPGGLIWGGGGAGGVGGAGGGTGGAGGRAELLFGAGGAGG Mb3541|M.bovis_AF2122/97 ----GAGGTGGNAAWLLGGGGTGGAGGIGGGNGGHGGNGGWLLGNGGNGG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------VGADGTSAH---------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 AR------------------------------------------------ Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------VVGATGA Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------IAGATGA MMAR_4316|M.marinum_M DGGAGFAGL-------------------------------PGGFAGGDGG MUL_4367|M.ulcerans_Agy99 --------------------------------------------AGQTAG Rv3508|M.tuberculosis_H37Rv AGTDG-----------------------------------GPGATGGTGG Mb3541|M.bovis_AF2122/97 LGGDGDGGTGGGHGGNGGNPGWLLGTAGGGGNGGAGSTGTAGGGSGGTGG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------VDGGTGG TH_3810|M.thermoresistible__bu -------------------------------------------HGGGTGI MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------GQGSTAV MAV_4827|M.avium_104 ----------------------------------------GLLLVGSGVD MLBr_01556|M.leprae_Br4923 ------------------------------------------PIPRPPAP Mflv_5091|M.gilvum_PYR-GCK VGAPG-------VAGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAG Mvan_1264|M.vanbaalenii_PYR-1 VGAPG-------VAGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAG MMAR_4316|M.marinum_M AGGFGGGGGLFGEGGAGGAGGVGG--AGTSGGDAVVPGGVGGVGGSGGAG MUL_4367|M.ulcerans_Agy99 AG----------VGGAGGAGGAGD--AGDQGVSGVAPGEAGAVGFAGGAG Rv3508|M.tuberculosis_H37Rv HGGVGGDGGWLAPGGAGGAGGQGG--AGGAGSDGGALGGTGGTGGTGGAG Mb3541|M.bovis_AF2122/97 DGGTGGRGGLLMGAGAGGHGGTGG--AGGAGVDG---GGAGGAGGAGGNG MSMEG_0868|M.smegmatis_MC2_155 TGGTGGG-----TGGTGGIGGTGGGLFGLLGHSG-STGAAGAAG-NGGDG TH_3810|M.thermoresistible__bu ISLLS-------LAGNGGNGGNGY-------------RTTDNNALDGGHG MAB_4284c|M.abscessus_ATCC_199 NGDVRDSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVD MAV_4827|M.avium_104 VAPLKQVLQTTTFLDVSVAEEPETALARGAALAAANAPLFASSTAALAYA MLBr_01556|M.leprae_Br4923 RPSASPSSMSPRPGGAVGGGGPRPPRTGVPRPGGGRPGAPVGGRSDAGGG . Mflv_5091|M.gilvum_PYR-GCK AAGAAG------AVGSAGAAGEAGETGTWGNAGLPGKAGDAGG-AGAVGA Mvan_1264|M.vanbaalenii_PYR-1 AAGKAG------AVGSAGTAGSAGAPGVWGNAGLPGAAGAAGG-AGAIGT MMAR_4316|M.marinum_M GAGGSGGGAGWLGTAGDGGVGGVGGGGGGGGVGASGVGHQLAG--GAGGA MUL_4367|M.ulcerans_Agy99 GAGGAGGNGVGGGVNGAGGAGGAGGVGGGGGAGASGVGAGVAG--GDGGT Rv3508|M.tuberculosis_H37Rv GAGGRG--ALLLGAGGQGGLGGAGGQGGTGGAGGDGVLGGVGGTGGKGGV Mb3541|M.bovis_AF2122/97 GAGGQA--ALLFGRGGTGGAGGYGGDGGGGGDGFDGTMAGLGGTGGSGGT MSMEG_0868|M.smegmatis_MC2_155 GNGGFG-YVLIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGG TH_3810|M.thermoresistible__bu GNGGNV------GFFSLFNLGGAGGWGGSGVDGVDVVGGNPDG--GTPGA MAB_4284c|M.abscessus_ATCC_199 DHSQRN----TTNINDSFNTDRSTNIGSGNTTNTEIGSHNQANIGTSTSA MAV_4827|M.avium_104 QDPGTG----AVDQYSLPDYLYVPVDPEPGDDELAYSAVGEEDAESPTVV MLBr_01556|M.leprae_Br4923 NYRGGG-----VGALPGGGSGGFRGRPGGGGHGGGGRPGQRGGAAGAFGR . Mflv_5091|M.gilvum_PYR-GCK AGAAGTVGTA------------GATGGTGTGANGGAGGVG---GVGGTGA Mvan_1264|M.vanbaalenii_PYR-1 AGVAGAAGTA------------GATGGTGVGGNGGAGQAG---GIGGTGA MMAR_4316|M.marinum_M GGAGGAAGAG--GAAGQGR--GGTVGAAGVGGTGGVGGDG---GAGDSGA MUL_4367|M.ulcerans_Agy99 GGAGGAAGVG--GAAGTG----GTGGAAGVAGTGGDGGDG---GAGGAGS Rv3508|M.tuberculosis_H37Rv GGVAGLGGAG--GAAGQLFSAGGAAGAVGVGGTGGQGGAG---GAGAAGA Mb3541|M.bovis_AF2122/97 GGDGGAPGNGGAGGAGQLLSHSGVAGASGKGGAGGTGGNG---GAGSAGA MSMEG_0868|M.smegmatis_MC2_155 GGGAILIGAN-----------GGTVDGHAIGGNGGNGGNGSTTAAGGNGG TH_3810|M.thermoresistible__bu HGESHTPGVY-----------------TDRQGEDGEDGTG---------- MAB_4284c|M.abscessus_ATCC_199 GGSAAVGGNAG------------LAGNAGLAGNAGLAGNAG--------- MAV_4827|M.avium_104 IEKLFLPEDS------------EPRRRPVLLVGSGLAVVG---------- MLBr_01556|M.leprae_Br4923 PGGAPRRGRKS-----------KRQKRQEYDSMQAPVVGGVRLPHGNGET . . Mflv_5091|M.gilvum_PYR-GCK AGAAG--GAGGLGETGTTGGAGGVGGQGTAG---GTGGVGGIGGAGSTGA Mvan_1264|M.vanbaalenii_PYR-1 AGAAG--QAGTAGETGVTGGVGGIGGQGTEG---GTGGVGGVGGVGATGG MMAR_4316|M.marinum_M AASAP-GGAGGTGWAGGAGGAGGAGGAAAAGGTAGVGGAGGDGGAGGVGA MUL_4367|M.ulcerans_Agy99 DASLA-GQAG---FAGGSGGAGGVGGSAGAG---GVNGSGGDGGAGAAGG Rv3508|M.tuberculosis_H37Rv DAPASTGLTGGTGFAGGAGGVGGQGGNAIAGGINGSGGAGGTGGQGGAGG Mb3541|M.bovis_AF2122/97 DAPAGSGAMGSTGFAGGAGGDGGNGGGSGAS--QGNGGNGGNGGTGGKGG MSMEG_0868|M.smegmatis_MC2_155 TGGTGRVIAEGTGSTAEGTATGGDGGHSTGT---GIGGNGGIGSVYAYGN TH_3810|M.thermoresistible__bu ---------------TGIGGRGGNGGSSSGT------HPMAEDGEHVKAL MAB_4284c|M.abscessus_ATCC_199 -------LAGNAGLAGNAGLAGNAGLAGNAG----LAGNAGLAGNAGLAG MAV_4827|M.avium_104 ---ISAVLALEIALAIGIRTTGTVALQPTPNQHLIVPTEQAPAPPPVQAS MLBr_01556|M.leprae_Br4923 IRLARGASLSDFAEKIDANPAALVQALFNLGEMVTATQSVGDETLELLGS . . . Mflv_5091|M.gilvum_PYR-GCK VGG----------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 AGG----------------------------------------------- MMAR_4316|M.marinum_M EGAAGAGVVGGGAGGDGGAGGAAGAGGSGGGGIGGGKAGTGGDGGIGGAG MUL_4367|M.ulcerans_Agy99 AGGASATVAG---------------------------------------- Rv3508|M.tuberculosis_H37Rv MGGSGADNASG-------------IGADGGAGGTGGNAGAGGAGGAAGTG Mb3541|M.bovis_AF2122/97 TGGAGMNSLDP--------------LLAAQDGGQGGTGGTGGNAGAGGTG MSMEG_0868|M.smegmatis_MC2_155 NGAVSGTATGG--------------------------------------- TH_3810|M.thermoresistible__bu DGR----------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 NAG----------------------------------------------- MAV_4827|M.avium_104 APQPKISVPEP--------------------------------------- MLBr_01556|M.leprae_Br4923 EMNYNVQVVSP--------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------VGGKGIQGGQGLQGG---------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------VGGKGIQGGQGLQGG---------------------- MMAR_4316|M.marinum_M GTGGGGGNGDTYSTGGAGGDGGAGGAAGSAGGAGAGSGGAAGSAGSGGSG MUL_4367|M.ulcerans_Agy99 -------------SGGVGGDGGAGGAAG--GGVGAAS------------- Rv3508|M.tuberculosis_H37Rv GTGGVVGAAGKAGIGGTGGQGGAGGAGS-AGTDATATGATGGTGFSGGAG Mb3541|M.bovis_AF2122/97 FTQGADGNAGNGGDGGVGGNGGNG-ADNTTTAAAGTTGGAGGAGGAGGTG MSMEG_0868|M.smegmatis_MC2_155 -------------RGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGG TH_3810|M.thermoresistible__bu ----------------PGLDGGNGSHGG---------------------- MAB_4284c|M.abscessus_ATCC_199 ------------LAGNAGLAGNAGLAGN---------------------- MAV_4827|M.avium_104 ------------VAAPKPLSPPVAAPLP---------------------- MLBr_01556|M.leprae_Br4923 --------EDEDRELLEPFDLTYGEDQGDEDELQVRPP------------ . Mflv_5091|M.gilvum_PYR-GCK ----------------------KGGDGGAGGKGGD----ADSMGSAGATG Mvan_1264|M.vanbaalenii_PYR-1 ----------------------QGGDGGTGGTGGD----ATSMGEAGATG MMAR_4316|M.marinum_M GDGGAGGASGRELGSNLGYAGGVGGDGGQGGQGGAAVGGLAGAAGSGGNG MUL_4367|M.ulcerans_Agy99 ----------------------LGGDGGHAGAGGAGGEGLSGGFNTGAAG Rv3508|M.tuberculosis_H37Rv GAGGAGGNTGVGGTNGSGGQGGTGGAGGAGGAGGVGADNPTGIGGTGGTG Mb3541|M.bovis_AF2122/97 GTGGAAG-TGTGGQQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQ-DG MSMEG_0868|M.smegmatis_MC2_155 SATGADS---------------LGGRGGTSWVQAGYGPTTGGKASGTAKA TH_3810|M.thermoresistible__bu ----------------------NGGHGGRGG-----------------FL MAB_4284c|M.abscessus_ATCC_199 ----------------------AGLAGNAGLAGNAGLAGNAGLAGNAGLA MAV_4827|M.avium_104 ---------------------AAPPPAAPPLPEAPPIPAAPPVVPVPVVV MLBr_01556|M.leprae_Br4923 -------------------VVTVMGHVDHGKTRLLDTIRKANVREAEAGG Mflv_5091|M.gilvum_PYR-GCK GKGGNG---------------GNGGRGGLFGK------GGNAGNGADGGT Mvan_1264|M.vanbaalenii_PYR-1 GKGGNG---------------GNGGRGSLFGR------GGNAGNGGNGGT MMAR_4316|M.marinum_M GAGGAGGASAVALVGGAGGAGGAGGQGGTAGD----GPGGVGGHGGSGGS MUL_4367|M.ulcerans_Agy99 GIGGAG---------------GAGGTGGDSG-----GVGGVNGDGGAGGG Rv3508|M.tuberculosis_H37Rv GKGGAG---------------GAGGQGGSSGAGGTNGSGGAGGTGGQGGA Mb3541|M.bovis_AF2122/97 GQGGTG---------------GTGGNAGAGGTGFTQGADGNAGNGGDGGV MSMEG_0868|M.smegmatis_MC2_155 GHGGKA---------------SDGGKGGNGGDALVMAAGATGVATGNTAI TH_3810|M.thermoresistible__bu GIGGSG---------------GWGGHGGNGGD--------TDADGGNGGD MAB_4284c|M.abscessus_ATCC_199 GNAGLA---------------GNAGLAGNAGLAGNAAVAGNAAVAGNAAV MAV_4827|M.avium_104 PPVPVP----------------VPVRIPVPDPVSPPQLLAPPRLSVPQPV MLBr_01556|M.leprae_Br4923 ITQHIG---------------AYQVGVDLDGSERLITFIDTPGHEAFTAM . Mflv_5091|M.gilvum_PYR-GCK GGAGGAGG-------------TGGTGGAGGTGGTGGTGGIG--------- Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGG-------------TGGTGGNGGTGGTGGTGGIG--------- MMAR_4316|M.marinum_M GGIGGTGGDGYQ---------SGDVGGQGGEGGAGGAAGAGGEAGAQGLA MUL_4367|M.ulcerans_Agy99 GGRGGDGGSSTS---------TSGVGGAGGAGGNGGNAGFG--------V Rv3508|M.tuberculosis_H37Rv GGAGGAGADNPTGIGG--AGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSV Mb3541|M.bovis_AF2122/97 GGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTGGAAGTG-TGGQQGNG MSMEG_0868|M.smegmatis_MC2_155 GGNGGAASAN------------GAVGGNGGFTNIAAIHGSITDSSATSGH TH_3810|M.thermoresistible__bu GGNG-------------------GSAGRGGTGGLRGVFGIN--------- MAB_4284c|M.abscessus_ATCC_199 AGNAAVGG----------------VLNTGVSGAIGGSSHVG--------- MAV_4827|M.avium_104 QPPVRVPQPPSP----------PQVGGTVPQSPPQHQTPPG--------- MLBr_01556|M.leprae_Br4923 RARGAKATDIAIL---------VVAADDGVMPQTVEAINHAQAADVPIVV . Mflv_5091|M.gilvum_PYR-GCK GAGSTGGTGGTGGTG-----------------------GTGGTGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 GAGSTGGTGGTGGTG-----------------------GTGGTGGTGGTG MMAR_4316|M.marinum_M GAGGTGGTGGQGGTGGIGAQGSNGHGVGGRPGTAGAVGGAGGAGGQGGAA MUL_4367|M.ulcerans_Agy99 SAGGTGGSAGDGGAG----------------------GGAGGVDGVGGAS Rv3508|M.tuberculosis_H37Rv GNAGIGGTGGTGGVGGAGGAGAAAAAGSSATGGAGFAGGAGGEGGAGGNS Mb3541|M.bovis_AF2122/97 GNGGNGGTGGKGGTGGAG-MNSLDPLLAAQDGGQGGTGGTGGNAGAGGTG MSMEG_0868|M.smegmatis_MC2_155 GGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKG----KAAGGNGGDGGFN TH_3810|M.thermoresistible__bu GGNGRAGLGGRGXXX------------------------XGGGVGAAVRS MAB_4284c|M.abscessus_ATCC_199 -GAINESLGGSGSVG-----------------------GSTAVGGGAHTG MAV_4827|M.avium_104 -EGTPPKPDGPGNYGGG-------------------HVPTPGAGGSGGSG MLBr_01556|M.leprae_Br4923 AVNKIDKEGADPAKIR----------------------GQLTEYGLVAED . * Mflv_5091|M.gilvum_PYR-GCK ------------GTGGTGGTGGKGGTG-----GTGGAGGTGGDGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 ------------GTGGTGGTGGKGGTG-----GTGGDGGTGGTGGTGGTG MMAR_4316|M.marinum_M GLDGTAGDGGVGGTGGRGGAGGDGAGG----VGHQLAGGAGGDGGAGGAA MUL_4367|M.ulcerans_Agy99 ------------GNGGAAGAGGAGGSG----IGAGIDGGAGGAGGTGGAA Rv3508|M.tuberculosis_H37Rv GVGGTNGSGGAGGAGGKGGTGGAGGSGADNPTGAGFAGGAGGTGGAAGAG Mb3541|M.bovis_AF2122/97 FTQGADGNAGNGGDGGVGGNGGNGADN-TTTAAAGTTGGAGGAGGAGGTG MSMEG_0868|M.smegmatis_MC2_155 -----------GTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRG TH_3810|M.thermoresistible__bu ------------GNGVFSGGGGTPSAG------FGVPTTIQFPAGSCTSR MAB_4284c|M.abscessus_ATCC_199 -----------VGGGVSTGVGVGSHVG------GGISESLGGSGSVGGST MAV_4827|M.avium_104 -----------GGHVPTPGAGGSGGSG-------GGHVPTPGTGGPGGTG MLBr_01556|M.leprae_Br4923 FG----------GDTMFIDISAKVGTNIEALLEAVLLTADAALDLRANSG . . Mflv_5091|M.gilvum_PYR-GCK GTG---------------GTGGTGGTGGTGGAGDG--------------- Mvan_1264|M.vanbaalenii_PYR-1 GTG---------------GTGGTGGTGGTGGAGDG--------------- MMAR_4316|M.marinum_M GVGGAAGA-GSGGVVGAAGTGGTGGAGGNGGAGDTGVAASTPGDPGGVGF MUL_4367|M.ulcerans_Agy99 GFP------GGGGTTGAWGTGGAGGAGGAGGAGDHGGVGVNPGDSGTAGW Rv3508|M.tuberculosis_H37Rv GAGGATGTGGTGGVVGATGSAGIGGAGGRGGDGGDGASGLGLGLSG---F Mb3541|M.bovis_AF2122/97 GTGGAAGT-GTGGQQGNGGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGG MSMEG_0868|M.smegmatis_MC2_155 GDG---------------GTFVNAGANGNGGAGGAGGVSEGEGGTGGHGG TH_3810|M.thermoresistible__bu AVS----------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AVG----------------------------------------------- MAV_4827|M.avium_104 GSG----------------------------------------------- MLBr_01556|M.leprae_Br4923 MEAQG--------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGTGGQGGQGGQG-GTGGTGGQGGLGGGGGT------------ Mvan_1264|M.vanbaalenii_PYR-1 LGGTGGTGGTGGFGGQGGQG-GTGGTGGQGGLGGVGGT------------ MMAR_4316|M.marinum_M AGGAGGAGGAGGASGVGGVN-GVGGAGGDGGTGGAGGAGAGGDRTDGGRG MUL_4367|M.ulcerans_Agy99 AGGAGGAGGAGGSAAFNGVN-GAGGAGGNGGAGGGGGAGASG-------- Rv3508|M.tuberculosis_H37Rv DGGQGGQGGAGGSAGAGGIN-GAGGAGGNGGDGGDGATGAAGLGDNGGVG Mb3541|M.bovis_AF2122/97 NGGDAGKAGTGSAPGTAGTG-GDGGKGGNGGIGAAGTTGPVGTGASGGTG MSMEG_0868|M.smegmatis_MC2_155 DGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDP-------- TH_3810|M.thermoresistible__bu --REGIMPSSRAASARAGAACASSTSRSRRSFCCSRA------------- MAB_4284c|M.abscessus_ATCC_199 GGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVG-------- MAV_4827|M.avium_104 -GGHVPTPGAGTPGGSGGGHLPFPGAGSTPGGSGGGHLPTPGAG------ MLBr_01556|M.leprae_Br4923 VAIEAHLDRGRGPVATVLVQRGTLRIGDSVVAGDAYGRVRRMVDEHG--- . Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_4316|M.marinum_M GVGGAGGDAGAGGVTGAGGSGGGVGNAGVGGAGGVGGAGGAGGAADGPGL MUL_4367|M.ulcerans_Agy99 --------------IGAG-------------------------------- Rv3508|M.tuberculosis_H37Rv GDGGAGGAAGNGGNAGVG-LTAKAGDGGAAGNGGNGGAGGAGGAGDN--- Mb3541|M.bovis_AF2122/97 GSGGAGGTGGDGGAANGG-------TAGAGGAGGNGGKGGDGGAGVTSST MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----GGQGGTGGTGGQGGTG------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 ----GGTGGTGGTGGQGGTG------------------------------ MMAR_4316|M.marinum_M FGYDGGAGGAGGIGGAAGVGGSNGAGGTGGAGGVGGVGADSGLASRPGGA MUL_4367|M.ulcerans_Agy99 --VAGGDGGTGGTGGAAGTG----------------------------GA Rv3508|M.tuberculosis_H37Rv -NFNGGQGGAGGQGGQGGLGGASTTSINANGGAGGNGGTGGKGGAGGAGT Mb3541|M.bovis_AF2122/97 AGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGGDGGD-------GAA MSMEG_0868|M.smegmatis_MC2_155 --SHTGAGGNGGNGGAGRIRVNNG----------------------TATG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----GGAHTGVGGGVNTGVG------------------------------ MAV_4827|M.avium_104 --TPGGGLGGFGGGHAPAPG------------------------------ MLBr_01556|M.leprae_Br4923 ----VDIEAALPSSPVQVIG------------------------------ Mflv_5091|M.gilvum_PYR-GCK -GTGGTGGTG----------------GTGGAGGDG--------------- Mvan_1264|M.vanbaalenii_PYR-1 -GTGGTGGTG----------------GTGGAGGDG--------------- MMAR_4316|M.marinum_M GGAGGTGGAGGGAGSGAGGLGAGGDGGTGGAGGAGGVGSSAGWGSGLAGQ MUL_4367|M.ulcerans_Agy99 AGTGGTGGAAGAAGS-------AGDGGAGGAGGAG--------------- Rv3508|M.tuberculosis_H37Rv LGVGGSGGTGGDGGDAGSGGGGGFGGAAGKAGGGGNGGRGGDGGDGASGL Mb3541|M.bovis_AF2122/97 GAVGISGATGAGDGGHGGTGGAGGNGGTGGAGGSGIDGVGG--GTGGTGG MSMEG_0868|M.smegmatis_MC2_155 TATGGNGGNGGNGD---------ADGHRGGKGGDG--------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_4316|M.marinum_M VGGAGGVGGAGGDSGGLGGTNGDGGAGGLGGRGGAGGSSTTVAGAGGGGG MUL_4367|M.ulcerans_Agy99 ------------DDGSAG-------------------------------- Rv3508|M.tuberculosis_H37Rv GLGLSGFDGGQGGQGGAGGSAGAGGINGAGGAGGNGGD------GGDGAT Mb3541|M.bovis_AF2122/97 NGGNGAIGGAGGDAGGSGNSGGNGGTGGKGGNAGAGG-------AAGSNG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_4316|M.marinum_M RGGDGGSAGGGVGGGGVGGAAGSGGAGGAGGRGIDSYAAAGGRGGDGGAG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GAAGLGDNGGVGGDGGAGGAAGNGGNAGVGLTAKAGDGGAAGNGGNGGAG Mb3541|M.bovis_AF2122/97 GTVGANGTGGDGGNGGAAGAATAGSNGGAGTGSAGGNGGTGGRGGSGGAG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------------------------------------------------GL Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------------------GL MMAR_4316|M.marinum_M GIGGGGGLSGIGGAGGQGGSGGAAGTGG-DVGGSPGEVGGAGGGGGFGGA MUL_4367|M.ulcerans_Agy99 -----------------------------VVSGDPGTAGKAG------GA Rv3508|M.tuberculosis_H37Rv GAGGAGDNNFNGGQGGAGGQGGQGGLGG-ASTTSINANGGAGGNGGTGGK Mb3541|M.bovis_AF2122/97 GDGIGGVGGGKGGNGADGEVGGAGGAGGSGPNTSPGGNGGQGGQGGSGGA MSMEG_0868|M.smegmatis_MC2_155 -------------------------------GEALIRATVIGSNASGTAT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGLGGFGG-----------------------SGGTGGQGGLGGPGGS--- Mvan_1264|M.vanbaalenii_PYR-1 GGLGGFGG-----------------------VGGTGGQGGQGGPGGS--- MMAR_4316|M.marinum_M GGAGGVGGGAGGSGGVGGSGGNGGLGVATGGAGGVGGQGGAAGAGGAAGA MUL_4367|M.ulcerans_Agy99 GGAGGVGG--------------------NGVAGGVNGSGGAGGAGGAGGT Rv3508|M.tuberculosis_H37Rv GGAGGAGTLG------------------VGGSGGTGGDGGDAGSGGGGGF Mb3541|M.bovis_AF2122/97 GGAAGAGGAG-------------------GGANGTAGNGGQGGAGGTGGA MSMEG_0868|M.smegmatis_MC2_155 GGDGGNGG----------------------TLGATNGTGGAATIVAYNVV TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 --------------------------------GGLGGGGGHAPAPG---- MLBr_01556|M.leprae_Br4923 -------------------------------FTSVPGAGDNFLVVDE--- Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------TGGAGGAGGQA Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------TGGAGGAGGQA MMAR_4316|M.marinum_M GATA--AGAGGVGGLGGDGGNGGNGV-RGAAGVAGGDGAVGGGGGAGGAG MUL_4367|M.ulcerans_Agy99 GG----AGASGVP-----------------ASVDGGD---GGAGGAGGAA Rv3508|M.tuberculosis_H37Rv GGAAGKAGGGGNGGVGGDGGEGASGLGLGLSGFDGGQGGQGGAGGSAGAG Mb3541|M.bovis_AF2122/97 GAASS-ATNGGSGGAGGTGGAGGTGG----AGGDGVGGAGGGNGGHGGDA MSMEG_0868|M.smegmatis_MC2_155 QANPQASGTATDG--------------------HGGSGINGGHGGNGGQG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------VGSHVGGGISE MAV_4827|M.avium_104 ----------------------------------------GGLGGFGGGH MLBr_01556|M.leprae_Br4923 ---------------------------------------DRIARQIADRR Mflv_5091|M.gilvum_PYR-GCK GTAGKGGLFGGS-------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GVAGKGGLFGGS-------------------------------------- MMAR_4316|M.marinum_M GQGGAGVTGGSAGAGGQGGNGGLGGPGGDGGSAVRYQRVGGAGGVGGVGG MUL_4367|M.ulcerans_Agy99 GTGGSGGSAGNTGAGG---------------------------------- Rv3508|M.tuberculosis_H37Rv GINGAGGAGGTGGAGGDGAPATLIG--GPDGGDGGQGGIGGDGGNAGFGA Mb3541|M.bovis_AF2122/97 GDGGNGANGNNRSSGSFLAAGGTGGAAGDGGQGGQGGAGGGAGGQGGAGG MSMEG_0868|M.smegmatis_MC2_155 TIEANGPSAVASGIG----------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SLGGSGSVGGSTAVG----------------------------------- MAV_4827|M.avium_104 SGGGLGGLGGGHK------------------------------------- MLBr_01556|M.leprae_Br4923 SARKRNALAARSRKR----------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_4316|M.marinum_M AAGAGGAAGQGGGGAVGAAGVGGTGGVGGNGGAGDAGVAGADGGGAGGSG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GVPGDGGDGGNAGFGAGVPGDGGIGGTGGAGGAGGAG-ADGDPSIDGGQG Mb3541|M.bovis_AF2122/97 AGGTGGNGGNITGGTAGTAGAAGNGGAAGKGGAGGQGGTGGGTGGQGGAG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------------------------GSAGKAGATGAAG------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------------GSAGTAGVTGASG------------- MMAR_4316|M.marinum_M WAGGAGGAGGQGGAANGGVA----GDGGVGGNGGVGG--------VGGRG MUL_4367|M.ulcerans_Agy99 -AGGAGGAGG--SAASTGVN----GDGGAGGAGGVGG--------LGG-- Rv3508|M.tuberculosis_H37Rv GAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGDGDGFIGGSG Mb3541|M.bovis_AF2122/97 GDGGAGGTGGDRTVGGGTVPAGSGGQGGNAGGGGAGGQG-------GADG MSMEG_0868|M.smegmatis_MC2_155 -AGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATG------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------GGAHTSAINDALG------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -----------ISLEDLDSALKETSQLNLILKGDNAG------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_4316|M.marinum_M GDGANG--APGGGIDGTGRPGGAGGQGGSGGRAGFGGAAGAGEGGEYGAA MUL_4367|M.ulcerans_Agy99 -DSAAT--AGGG-------------------------------------- Rv3508|M.tuberculosis_H37Rv GTGGTGGDAGVGGLANTGGTAGNAGIGGAGGRGGDGGAGDSGALSQDGNG Mb3541|M.bovis_AF2122/97 GSGGDGGDAGTGGNGGNGGNRNSGNGTGGAGGNGGGGANGGAGGAGGSGG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------T TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ASGGKGAQG----------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ASGGKGAQG----------------------------------------- MMAR_4316|M.marinum_M GVGGNGGDGGAGGRGGYGTTGSGGLFGGSGGHGGVGGIGGNGGSAAAGGV MUL_4367|M.ulcerans_Agy99 GAGGDGGKGGAGG----------------------------------AGV Rv3508|M.tuberculosis_H37Rv FAGGQGGQGGVGGNAGAGGINGAGGTGGTGGAGG-DGQNGTTGVASEGGA Mb3541|M.bovis_AF2122/97 GTGGNGGAGGDAGDAGNGGNGNGTGNGGNGGNGGIAGMGGNGGAGTGSGN MSMEG_0868|M.smegmatis_MC2_155 ATGGDGGKAT---------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------ATGAQGATGAQGATG------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------ATGAQGATGAQGATG------- MMAR_4316|M.marinum_M NGNGGNGGIGGNAGDAGNGANGSLLHHAGDGGNGGRGGAGGAGGFAGDGE MUL_4367|M.ulcerans_Agy99 NGVGG-----------------------GDGGKGGTGGAGGAG------- Rv3508|M.tuberculosis_H37Rv GGQGGDGGQGGIGGAGGNAGFGAG--VPGDGGIGGTGGAGGAGGAGADGD Mb3541|M.bovis_AF2122/97 GGNGGSGGNGGNAGMGGNSGTGS-----GDGGAGGNGGAAGTGGTGGDGG MSMEG_0868|M.smegmatis_MC2_155 ----------------------------GTASQGGNGGPSWVQS------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------------------------------------ATGAAGKAGATGAA Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------ATGASGAQGSAGSA MMAR_4316|M.marinum_M GSGG--TAGSGGNGGKGGNAGAGGNG-VPAAGAAAGNGGLGGSGGAGGSG MUL_4367|M.ulcerans_Agy99 --------------------GAGSDG-IIPS-----NGGLGGNGGNGGNG Rv3508|M.tuberculosis_H37Rv PS------IDGGQGGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAG Mb3541|M.bovis_AF2122/97 LTGTGGTGGSGGTGGDGGNGGNGGNGADNTANMTAQAGGDGGNGGDGGFG MSMEG_0868|M.smegmatis_MC2_155 -------------------GYGSTLGGNATGTATAGKGGEASNGGVAGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------------------------------------TVEALEEALMGIQ Mflv_5091|M.gilvum_PYR-GCK GAAG---------AAGSAGTTGAQGSAG---------------TNGANGA Mvan_1264|M.vanbaalenii_PYR-1 GSAG---------VAGSAGTTGAQGSAG---------------TNGANGA MMAR_4316|M.marinum_M AIGAAAGG-----AGGAGGNGGTGGNAGIGVMRGAS--TPALAGDGGVGG MUL_4367|M.ulcerans_Agy99 GQ-AFGDG-----VGGAGGIGGKGGNAAIGTIVIN-------GGVGGAGG Rv3508|M.tuberculosis_H37Rv GNGGDGDGF----IGGSGGTGGTGGDAGVGGLANTG-GTAGNAGIGGAGG Mb3541|M.bovis_AF2122/97 GGAGAGGGGLTAGANGTGGQGGAGGDGGNGAIGGHGPLTDDPGGNGGTGG MSMEG_0868|M.smegmatis_MC2_155 GNALVMAAG---TTGVATGNTATGGDGGAATTAGAT------GGAGGFSN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------GSGSVGG MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 VDDEVALRVIDRGVGGITETNVNLASASDAIIIGFN------VRAEGKAT Mflv_5091|M.gilvum_PYR-GCK NGSQGAAGKAGATGTTGATGAAGEDGDAG--------------------- Mvan_1264|M.vanbaalenii_PYR-1 NGSQGAAGKAGATGTTGATGAAGDAGDPG--------------------- MMAR_4316|M.marinum_M AGGLGGVARS-VGGVGG-VGGDGGSGGTGGIGTTGNSA-TNGYGGAGGAG MUL_4367|M.ulcerans_Agy99 SGGLGGATEDGVGGVGC-AGGAGGNGGRGDMLFT--------------VG Rv3508|M.tuberculosis_H37Rv RGGDGGAGDSGALSQDG-NGFAGGQGGQGGVGGNAGAGGINGAGGTGGTG Mb3541|M.bovis_AF2122/97 NGGTGGTGGAGIGSLGGGTGGDGGNGGTGGNGGTGGEG--GEVGGAGGTG MSMEG_0868|M.smegmatis_MC2_155 IAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYD------------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 STAVGGGAHTSAINESMNSSINASHSSSMNESFG---------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 ELASREGVEIRYYLVIYQAIDDIEKALRGMLKPIYEEN------------ Mflv_5091|M.gilvum_PYR-GCK -SGGSGING--------GAGGAGGAGGEGGEG-------------GDGGK Mvan_1264|M.vanbaalenii_PYR-1 -SEAVDING--------GAGGAGGAGGEGGEG-------------GAGGA MMAR_4316|M.marinum_M GAGGVGGNGGFAALGTGGAAGSGGGGGTGGAGGVSDSPTTSRSVGGAGGV MUL_4367|M.ulcerans_Agy99 GSGGTGGDG--------GGGGSASGSGTGGSG-------------GTGGV Rv3508|M.tuberculosis_H37Rv GAGGDGQNGTTGVASEGGAGGQGGDGGQGGIGGAGGNAGFGAGVPGDGGI Mb3541|M.bovis_AF2122/97 GAAGNGGDGGTGGTG-GGDGGAGGTGGTGGTGGLGDP-----RVGGSGGD MSMEG_0868|M.smegmatis_MC2_155 -PAGPVGSKIANSSAVAGNGGDGGVNGTGGASG------------GDGGN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------SSMGSHGAAGTGFEAQG-----------HAQGH MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 QLGRAEIRALFRSSKVGIIAGCIISSGVVRRNAKVRLLRDNIVVTDNLTV Mflv_5091|M.gilvum_PYR-GCK GGAGAEGGAGGGGGAG------GSG------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GGDGSEGGAGGSGGAG------GSG------------------------- MMAR_4316|M.marinum_M GGVGGNGGIGGNGQIG------GDGGSGGAAGAGGAGAQNLTRSIQSAN- MUL_4367|M.ulcerans_Agy99 GGIGGDGKLGGFGGDG------GDGGDGG--------------------- Rv3508|M.tuberculosis_H37Rv GGTGGAGGAGGAGADGDPSIDGGQGGAGGHGGQGGKGGLNSTGLASAASG Mb3541|M.bovis_AF2122/97 GGTGGSGGAAGNGGNG------GNAGAGGNG------------------- MSMEG_0868|M.smegmatis_MC2_155 GGNTSVWKSGGQTADG------EHN------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ASETAHTTLPGAEHH----------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 TSLRREKDDVTEVREG---------------------------------- Mflv_5091|M.gilvum_PYR-GCK ------AGGAGGAGGSGGSGGSGGS------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------TGGAGGAGGSGGSGGSGGA------------------------- MMAR_4316|M.marinum_M ------FGGAGGAGGVGGFGGVGGT----------------GASGLGGSG MUL_4367|M.ulcerans_Agy99 ------FGVIGGQGGGGGFGGLGGT----------------GAG------ Rv3508|M.tuberculosis_H37Rv DGGNGGAGGAGGNGGAGGLGGGGGTGGTNGNGGLGGGGGNGGAGGAGGTP Mb3541|M.bovis_AF2122/97 ------NGGTGGAGGIGGTGGNGGD---------------AEPGVPPGAG MSMEG_0868|M.smegmatis_MC2_155 ------TGGNGGNGGDGSEPGPGGN------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 -------FECGMTLGYSDIKEGD--------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------------------GGSGGAAGDSDD------ Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------GGSGGAAGDSD------- MMAR_4316|M.marinum_M GIGGDGGAGGVGGDCSVPLSPGNGGDGGAGGDGGDGGDGGNGQPGGPGGA MUL_4367|M.ulcerans_Agy99 --------------------------------GAPSDKGINGEPGNPG-- Rv3508|M.tuberculosis_H37Rv TGSGTEGTGGDGGDAGAGGNGGSATGVGNGGNGGDGGNGGDGGNGAPGGF Mb3541|M.bovis_AF2122/97 GAGGAGTTGGKGGTGGNGSGTGSGGTGGDGGTGGGGGNGGTGWNGGKGDT MSMEG_0868|M.smegmatis_MC2_155 ------------------------------GAGGAGGNGGTGGTTAGGSG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01556|M.leprae_Br4923 --------------------------------VIESYELVEKQRA----- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------- MMAR_4316|M.marinum_M GGGAASGGAGGYGQLGNGAAGADGNNGTPGADG-- MUL_4367|M.ulcerans_Agy99 ----------------------------------- Rv3508|M.tuberculosis_H37Rv GGGAGAGGLGGSGAGG-GTDGDDGNGGSPGTDGS- Mb3541|M.bovis_AF2122/97 GSGGGAGDGGKAPAGGTGGAGGDGGAGGKGGSGGV MSMEG_0868|M.smegmatis_MC2_155 NGGNGGNGGNGGADGTPGTAGTTGANNP------- TH_3810|M.thermoresistible__bu ----------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------- MAV_4827|M.avium_104 ----------------------------------- MLBr_01556|M.leprae_Br4923 -----------------------------------