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SYMSISPEIVSSAAGELANIGSTVSAANAAAAVATTELLAAGSDEVSTRIAALFGANGVEYQAISAQIAS FHDRFVAALNTGTSSYVWAEATNVEQNLLNAVNAPVQTLLGRPLIGNGANATTPGGAGGDGGLLYGSGGN GAAGAPGQAGGAGGSAGLWGNGGSGGSGGIGGGTGGNGGSGGWLLGRGGIGGAGGTGGGSGGSGGGAWLF GDGGAGGMGGTGGSGGGFGGTGGHGGLLYGNGGAGGAGATGQTGGSGGWAALWGRGGAGGAGGDNGGFAG GDGGHGGLLCGAGGDGGLGGGDGGNAGWLLGFGGHGGAGGDGGFAGGEGGNGGWLLGFGGHGGTGGIGGG TGGAGGAGGLVMGFGGHGGTGGIGGGAGGAGGQAALLFGHGGGGGAGGVGTAGGAGGAGGDGGNPGWLLG RAGSGGDGGAGGAATTVGATGGVGGHGGAGGRGGVLMGGGAGGDGGAGGAGADGSNGVGDGGNGATGGGG GVGGDGGAGGQAALLFGCGGTGGHAGAGGAGGGGGTGADSLTGIGGAGGDGGIGGASGQAGAGGAGNLFS HNGSRGHAGIGGDGGDGGTGGTGGEGTDAAAGSGLTGGTGYAGGTGGTGGAGGNSGLGGTNGSGGHGGTG GTGGTGGTGGSGADNTTGIGGDGGQGGTGGDAGAGGAGGNSGFGGTGGTTGTHGDAGIGGDGGDGGTGGT GGQGTDAAAGTGLTGGTGYAGGTGGAGGAGGNSGLGGTNGSGGHGGTGGTGGTGGTGGSGADALDGSGAS GHDGGDSGAGGDGGTGGAGGNAGTGAGAAGNNGDGGAGGTGGNSGAQAGDGGAGAANTTIGGTGGAGGSG GNIGAGGAGGQGGAAGTTSGVGGASGTSGTSGQSIGTGGDGGAGGDGGTGTTGADAAAGSGLGGDIGGTG GAGGAGGTGGSGGTDSGVGGSGGVGGVGGTGGQGGAGSDNSANAGVAGGAGGQGGAGGTGGAAGSGGTGS VAGADGSSGDGGTGGLGGDGGAGGTGSMGAVDGGTGGQGASGGAGGQGGTGGAAGAGTGGIQGAGGQGGT GGTGGTGGTGGDGAESTDPSLAGQAGGQGGTGGTGGAAGQGGTGSVTGAEGSAGDGGTGGLGGDGGTGAD NTTTVSAGAQGATGGTGGAGGQGGTGGAAGTGTGGIQGAGGQGGTGGTGGQGGTGGDGAESTDPTLAAQA GGQGGTGGTGGAAGQGGTGSTMGAEGSSGDGGTGGLGGDGGAGADNTTTVSTGAQGATGGTGGAGGQGGT GGAAGTGTGGIQGAGGQGGTGGTGGTGGSGGDGTDNSTTPGAAGGAGGQGGTGGTGGAAGSGGTGSTMGA EGSSGDGGTGGLGGDGGEGGQGTTAWNPGDTGGQGASGGAGGTGGTGGAAGTGTGGIQGAGGQGGTGGTG GQGGTGGDGTDNSTTPGAAGGAGGQGGTGGTGGAAGTGGTGSTMGAEGSSGDGGSGGLGGDGGAGGQGTT GTAGAGTGGQGASGGAGGQGGTGGAAGTGTGGIQGAGGQGGTGGTGGTGGIGGTGTDSTDPSQIAQAGGQ GGTGGTGGAAGQGGTGSTIGSAGTAGDGGTGGLGGDGGTGADNTTTVSAGAQGATGGTGGAGGQGGTGGA AGTGTGGIQGAGGQGGTGGTGGQGGTGGDGADSTDPTLAGQAGGQGGTGGTGGAAGQGGTGSTSGSEGSS GDGGTGGLGGDGGAGADNTTTVSAGAQGATGGTGGAGGQGGTGGAAGTGTGGTQGAGGQGGTGGTGGQGG TGGDGTDNSTTPGAAGGAGGQGGTGGTGGAAGQGGTGSTMGSDGSSGDGGTGGLGGDGGEGGQGTTGTAG AGTGGQGASGGAGGTGGTGGAAGTGTGGIQGAGGQGGTGGTGGQGGTGGDGADSTDPTLAGQAGGQGGTG GTGGAAGQGGTGSVAGTDGSSGDGGTGGLGGHGGAGADNTTTVSAGAQGATGGTGGAGGTGGTGGAAGTG TGGIQGAGGQGGTGGTGGQGGTGGDGTDNSTTPGAAGGAGGQGGTGGTGGAAGQGGTGSTSGSAGSSGDG GTGGLGGDGGEGGQGTTGTAGAGTGGQGASGGAGGQGGTGGAAGTGTGGTQGAGGQGGTGGTGGTGGIGG TGTDSTDPSQIAQAGGQGGTGGTGGAAGQGGTGSTMGSAGTAGDGGTGGLGGHGGTGADNTTTVSAGAQG ATGGTGGAGGQGGTGGAAGTGTGGTQGAGGQGGTGGTGGQGGTGGTGTDSTDPTLVGQAGGQGGTGGTGG AAGQGGTGSVTGAEGSAGDGGSGGLGGHGGTGADNTTAVSAGAQGATGGTGGAGGQGGTGGAAGTGTGGI QGAGGQGGTGGTGGQGGTGGTGTDSTDPTLAGQAGGQGGTGGTGGAAGSGGTGSTMGAEGSSGDGGTGGL GGDGGTGGQGTTAVNPGDTGGQGASGGAGGTGGTGGAAGTGTGGTQGAGGQGGTGGTGGQGGTGGDGTDN STTPGAAGGAGGQGGTGGTGGAAGSGGTGSTMGAEGSSGDGGTGGLGGDGGTGGQGTTAVNPGDTGGQGA SGGAGGTGGTGGAAGTGTGGTQGAGGQGGTGGTGGQGGTGGDGTDNSTTPGAAGGAGGQGGTGGTGGAAG SGGTGSTMGAEGSSGDGGTGGLGGAGGTGGQGTTAVNPGDTGGQGASGGAGGTGGTGGAAGTGTGGIQGA GGQGGTGGAGGSGGTGGDGTDNSTTPGAAGGAGGQGGTGGTGGAAGSGGTGSTMGAEGSSGDGGTGGLGG AGGTGGQGTTAVNPGDTGGQGASGGAGGTGGTGGAAGTGTGGIQGAGGQGGTGGTGGQGGTGGDGAESTD PTLAGQAGGQGGTGGTGGAAGQGGTGSVAGTDGSAGDGGTGGLGGHGGAGADNTTTVSAGAQGATGGTGG AGGQGGTGGAAGTGTGGTQGAGGQGGTGGTGGTGGIGGTGTDSTDPSQIAQAGGQGGTGGTGGAAGQGGT GSTMGSAGTAGDGGTGGLGGGGGTGADNTTAVSAGAQGATGGTGGAGGQGGTGGAAGTGTGGIQGAGGQG GTGGTGGTGGIGGTGTDSTDPTLAGQAGGQGGTGGTGGAAGTGGTGSVTGTDGTAGDGGTGGLGGHGGAG ADNTTTVSAGAQGATGGTGGAGGTGGTGGAAGTGTGGTQGAGGQGGTGGTGGTGGIGGTGTDSTDPSQIA QAGGQGGTGGTGGAAGSGGTGSVTGTDGTAGDGGTGGLGGDGGAGADNTTTVSAGAQGATGGTGGAGGQG GTGGAAGTGTGGIQGAGGQGGTGGAGGSGGTGGDGTDNSTTPGAAGGAGGQGGTGGTGGAAGQGGTGSTM GSDGSSGDGGTGGLGGDGGGAGQGTTGTAGAGTGGQGASGGAGGQGGTGGAAGTGTGGTQGAGGQGGTGG TGGTGGTGGTGTDSTDPSQIAQAGGQGGTGGTGGAAGQGGTGSTMGAEGSSGDGGTGGLGGHGGAGADNT TTVSAGAQGATGGTGGAGGQGGTGGAAGTGTGGTQGAGGQGGTGGTGGTGGIGGTGTDSTDPSQIAQAGG QGGTGGTGGAAGQGGTGSTMGSAGTAGDGGTGGLGGGGGTGADNTTTVSAGAQGATGGTGGAGGQGGTGG AAGTGTGGIQGAGGQGGTGGTGGTGGIGGTGTDSTDPTLAGQAGGQGGTGETGGAAGSGGTGS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_1594 | - | - | 100% (3634) | PE-PGRS family protein |
M. marinum M | MMAR_5294 | - | 0.0 | 50.06% (2413) | PE-PGRS family protein |
M. marinum M | MMAR_2656 | - | 0.0 | 48.59% (2163) | PE-PGRS family protein, PE_PGRS50 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3541 | PE_PGRS55 | 0.0 | 54.54% (2050) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 48.72% (862) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 0.0 | 52.75% (1907) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 2e-10 | 33.70% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 4e-57 | 31.12% (556) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 9e-23 | 40.91% (198) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-179 | 41.25% (1086) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 5e-45 | 40.00% (310) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 48.63% (1164) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 0.0 | 48.43% (861) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_1594|M.marinum_M -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M -----------------------------------------MSYMSISPE Mb3541|M.bovis_AF2122/97 -----------------------------------------MSFVLISPE Rv3508|M.tuberculosis_H37Rv -----------------------------------------MSFVLIAPE MUL_4367|M.ulcerans_Agy99 -----------------------------------------MSFVSVGPG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 ----------------------------------------MPLFLNAEPQ MAV_4827|M.avium_104 --------------------------------------MNIVLGVSMAPS MMAR_1594|M.marinum_M IVSSAAGELANIGSTVSAANAAAAVATTELLAAG---------------- Mb3541|M.bovis_AF2122/97 VVSAAAGDLANVGSTISAANKAAAAATTQVLAAG---------------- Rv3508|M.tuberculosis_H37Rv FVTAAAGDLTNLGSSISAANASAASATTQVLAAG---------------- MUL_4367|M.ulcerans_Agy99 LLEAAARDLAGLGAGLREANLAAAGATVGVLPAA---------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------MMFLAPPGGPGPISAAIQLTSTG---------------- MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --MSIIDFILNLFRDPVEAASYVADPEAALANAG---------------- MLBr_01183|M.leprae_Br4923 ALTAAANTLEGLSAATVASNAAAAQLTTEIAPPA---------------- MAV_4827|M.avium_104 SIQMVVLEGEYADGATVEEDAIDVTGADDAATAS---------------- MMAR_1594|M.marinum_M ----SDEVSTRIAALFGANGVEYQAISAQIASFHDRFVAALNTGTSSYVW Mb3541|M.bovis_AF2122/97 ----ADEVSARIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYML Rv3508|M.tuberculosis_H37Rv ----ADEVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYAS MUL_4367|M.ulcerans_Agy99 ----GDEVSAAIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQ Mflv_5091|M.gilvum_PYR-GCK ------------MVTFGGGA------TPTPTSLGAAAVDLSGTSCG---- Mvan_1264|M.vanbaalenii_PYR-1 ----SEATEPWYVVSFGGSG------APTPNNLAASLVDLSGTSCG---- MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------LSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGN MLBr_01183|M.leprae_Br4923 ----ADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSAY-- MAV_4827|M.avium_104 ---APDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARR MMAR_1594|M.marinum_M AEATN---------------VEQNLLNAVNAPVQTLLGRPLIGNGAN-AT Mb3541|M.bovis_AF2122/97 AEATN---------------VEQNLLNLINAPTQTLLGRPLIGDGAN-AT Rv3508|M.tuberculosis_H37Rv AEAA---------------AAEQIVLGVINAPTQALLGRPLIGDGAN-AT MUL_4367|M.ulcerans_Agy99 AEALNMWPLQ---------ELEQQALGVVNAPSMALFGRPSIGNGVDGVA Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------LICNGQD--- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------LICNGQD--- MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGIN-GT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LQN----------------------------------YYAAQPDGPSILS MLBr_01183|M.leprae_Br4923 -------------------------------------------AGTE--- MAV_4827|M.avium_104 IDN-------------------------------------VMLVSAFLAA MMAR_1594|M.marinum_M TPGGAGGDGGLLYGSGGNGA-AGAPGQAGGAGGSAGLWGNGGSGGSGGIG Mb3541|M.bovis_AF2122/97 TPGGAGGDGGLLFGSGGNGA-PGAPGQAGGAGGSAGLLGNGGSGGAGGTG Rv3508|M.tuberculosis_H37Rv TPGGAGGAGGLLFGNGGAGA-AGAPGQAGGPGGPAGLWGNGGPGGAGGSG MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGG-- Mflv_5091|M.gilvum_PYR-GCK ---GTGQNGGILFGNGGSGWNSDVVGMDGGNGGNGGLFG--GNGGNGGNG Mvan_1264|M.vanbaalenii_PYR-1 ---GTGQNGGILFGNGGSGWNSEIAGVSGGNGGNAGLFG--GNGGNGGNG MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFGNGGNGGVGWAG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 PSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPLLDLS MLBr_01183|M.leprae_Br4923 ----TANHDSL--------------------------------------- MAV_4827|M.avium_104 AALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAES MMAR_1594|M.marinum_M GGTGGNGGSGGWLLGRGGIGGAGGTGGGSGGSGGGAWLFGDGGAGGMGGT Mb3541|M.bovis_AF2122/97 -APGGNGGNAGWLYGRGGVGGAGGIGGGTGGAGGHAWLFGHGGTG----- Rv3508|M.tuberculosis_H37Rv GGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGG---------------- MUL_4367|M.ulcerans_Agy99 ---------------VGAAG----MTGGSGGAGG---------------- Mflv_5091|M.gilvum_PYR-GCK ------------------------LGGGNGGNGG---------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------------LGSGDGGNGG---------------- MSMEG_0868|M.smegmatis_MC2_155 -----------LDGGNGGSGGLLMGIGGAGGAGG---------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------FGDLQFGN---------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------------YGDAAG---------------- MMAR_1594|M.marinum_M GGSGGGFGGTGGHGGLLYGNGGAGGAGATGQTGGSGGWAALWGRGGAGGA Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GGDNGGFAGGDGGHGGLLCGAGGDGGLGGGDGGNAGWLLGFGGHGGAGGD Mb3541|M.bovis_AF2122/97 -------------------------GIGGGPGGNGGWLLGNGGHGGAGGI Rv3508|M.tuberculosis_H37Rv ---------------------------------PGGLIWGGGGAGGVGGA MUL_4367|M.ulcerans_Agy99 ---------------------------------GGGWLWGAGGSGGAAGA Mflv_5091|M.gilvum_PYR-GCK ----------------------------------NAGAFALFGNGGNGGN Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------DAGLFSLFGRGGNGGN MSMEG_0868|M.smegmatis_MC2_155 ------------------------------VGADGTSAHVDGGTGGTGGT TH_3810|M.thermoresistible__bu ---------------------------------------VD----GDGGS MAB_4284c|M.abscessus_ATCC_199 ---------------------------------RDTTAIGDGAVAVGGSN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------------------QLSAMVAGLEKLESLP MMAR_1594|M.marinum_M GGFAGGEGGNGGWLLGFGGHGGTGGIGGGTGGAGGAGGLVMGFGGHGGTG Mb3541|M.bovis_AF2122/97 GGGSGGAGGNGGWLLGNGGIGGAGGTGGGAGGTGGNAAWLLGGGGTGGAG Rv3508|M.tuberculosis_H37Rv GGGTGGAGGRAELLFGAGGAGGAGTDGG------------------PGAT MUL_4367|M.ulcerans_Agy99 GG------------------------------------------------ Mflv_5091|M.gilvum_PYR-GCK GG------------------------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 GG------------------------------------------------ MSMEG_0868|M.smegmatis_MC2_155 GG------------------------------------------------ TH_3810|M.thermoresistible__bu GG------------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 SG------------------------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GG------------------------------------------------ MMAR_1594|M.marinum_M GIGGGAGGAGGQAALLFGHGGGGGAGGVGTAGGAGGAGGDGGNPGWLLGR Mb3541|M.bovis_AF2122/97 GIGGGNGGHGGNGGWLLGNGGNGGLGGDGDGGTGGGHGGNGGNPGWLLGT Rv3508|M.tuberculosis_H37Rv GGTGGHGGVGGDGGWLAPGGA-GGAGGQGGAGGAGSDGGALGGTGGTGGT MUL_4367|M.ulcerans_Agy99 --------SGGSGGWLWG---------------------------NAGQT Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M AGSGGDGGAGGAATTVGATGGVGGHGGAGGRGGVLMGGGAGGDGGAGGAG Mb3541|M.bovis_AF2122/97 AGGGGNGGAGSTGTAGGGSGGTGGDGGTGGRGGLLMGAGAGGHGGTGGAG Rv3508|M.tuberculosis_H37Rv GGAGGAGGRGALLLGAGGQGGLGGAGGQGGTG------GAGGDGVLGGVG MUL_4367|M.ulcerans_Agy99 AGAG-----------------VGGAGGAGGAG------DAGDQGVSG--- Mflv_5091|M.gilvum_PYR-GCK ---------------------VGVVGATGAVG------------------ Mvan_1264|M.vanbaalenii_PYR-1 ---------------------VGIAGATGAVG------------------ MSMEG_0868|M.smegmatis_MC2_155 --------------------GTGGTGGIGGTGG----------------- TH_3810|M.thermoresistible__bu --------------------RTG--------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------PIASGQGSTAVN------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------LLLVGSGVDVAP-------------------- MMAR_1594|M.marinum_M ADGSNGVGDGGNGATGGGGGVGGDGGAGGQAALLFGCGGTGGHAGAGGAG Mb3541|M.bovis_AF2122/97 GAGVDGGG------AGGAGGAGGNGGAGGQAALLFGRGGTGGAGGYGGDG Rv3508|M.tuberculosis_H37Rv GTGG----------KGGVGGVAGLGGAGGAAGQLFSAGGAAGAVGVGGTG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GGGGTGADSLTGIGGAGGDGGIGGASGQAGAGGAGNLFSHNGSRGHAGIG Mb3541|M.bovis_AF2122/97 GGGGD--------------------------------------------- Rv3508|M.tuberculosis_H37Rv GQGGA--------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GDGGDGGTGGTGGEGTDAAAGSGLTGGTGYAGGTGGTGGAGGNSGLGGTN Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GSGGHGGTGGTGGTGGTGGSGADNTTGIGGDGGQGGTGGDAGAGGAGGNS Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GFGGTGGTTGTHGDAGIGGDGGDGGTGGTGGQGTDAAAGTGLTGGTGYAG Mb3541|M.bovis_AF2122/97 GFDGT--------MAGLGGTGGSGGTGGDGG-----------------AP Rv3508|M.tuberculosis_H37Rv ---GGAGAAGADAPASTGLTGGTGFAGGAGG-----------------VG MUL_4367|M.ulcerans_Agy99 --------------VAPGEAGAVGFAGGAGG-----------------AG Mflv_5091|M.gilvum_PYR-GCK ---------------APGVAGATGATGVTSG----------------VVG Mvan_1264|M.vanbaalenii_PYR-1 ---------------APGVAGATGATGVTSN----------------VTG MSMEG_0868|M.smegmatis_MC2_155 -----------GLFGLLGHSGSTGAAGAAGN------------------G TH_3810|M.thermoresistible__bu ------------LFSKLSR------------------------------G MAB_4284c|M.abscessus_ATCC_199 -----------------GDVRDSNIINADHG---------------SNVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------LKQVLQTTTFLDVSVAE-----------------E MMAR_1594|M.marinum_M GTGGAGGAGGNSGLGGTNGSGGHGGTGGTGGTGGTGGSGADALDGSGASG Mb3541|M.bovis_AF2122/97 GNGGAGGAG----------------------------------------- Rv3508|M.tuberculosis_H37Rv GQGGNAIAG----------------------------------------- MUL_4367|M.ulcerans_Agy99 GAGGNGVGG----------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GNGEDAVG------------------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 GNGADAVG------------------------------------------ MSMEG_0868|M.smegmatis_MC2_155 GDGGNGGFGYV--------------------------------------- TH_3810|M.thermoresistible__bu GDGGDGGLG----------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VDQSQTRVG----------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PETALARG------------------------------------------ MMAR_1594|M.marinum_M HDGGDSGAGGDGGTGGAGGNAGTGAGAAGNNGDGGAGGTGGNSGAQAGDG Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GAGAANTTIGGTGGAGGSGGNIGAGGAGGQGGAAGTTSGVGGASGTSGTS Mb3541|M.bovis_AF2122/97 --------------------------------QLLSHSGVAGAS------ Rv3508|M.tuberculosis_H37Rv --------------------------------------GINGSG------ MUL_4367|M.ulcerans_Agy99 --------------------------------------GVNGAG------ Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GQSIGTGGDGGAGGDGGTGTTGADAAAGSGLGGDIGGTGGAGGAGGTGGS Mb3541|M.bovis_AF2122/97 ----GKGGAGGTGGNGGAGSAGADAPAGS---GAMGSTGFAGGAGGDGGN Rv3508|M.tuberculosis_H37Rv ----GAGGTGGQGGAGGMGGSGADNASGIGADGGAGGTGGNAGAGGAGGA MUL_4367|M.ulcerans_Agy99 ----GAGGAGGVGGGGGAGASGVG----AGVAGGDGGTGGAGGAAGVGGA Mflv_5091|M.gilvum_PYR-GCK -----YGATGAAGAAGAAGAAGAA--------GAVGSAGAAGEAGETGTW Mvan_1264|M.vanbaalenii_PYR-1 -----YGATGAAGAAGAAGAAGKA--------GAVGSAGTAGSAGAPGVW MSMEG_0868|M.smegmatis_MC2_155 -LIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIG TH_3810|M.thermoresistible__bu -----------------------------------GNGGHGGGTGIISLL MAB_4284c|M.abscessus_ATCC_199 ---------GDYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------AALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVP MMAR_1594|M.marinum_M GGTDSGVGGSGGVGGVGGTGGQGGAGSDNSANAGVAGGAGGQGGAGGTGG Mb3541|M.bovis_AF2122/97 G------------------------------------------------- Rv3508|M.tuberculosis_H37Rv AG------------------------------------------------ MUL_4367|M.ulcerans_Agy99 AG------------------------------------------------ Mflv_5091|M.gilvum_PYR-GCK GN------------------------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 GN------------------------------------------------ MSMEG_0868|M.smegmatis_MC2_155 AN------------------------------------------------ TH_3810|M.thermoresistible__bu S------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TN------------------------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VD------------------------------------------------ MMAR_1594|M.marinum_M AAGSGGTGSVAGADGSSGDGGTGGLGGDGGAGGTGSMGAVDGGTGGQGAS Mb3541|M.bovis_AF2122/97 --------------------------------------------GGSGAS Rv3508|M.tuberculosis_H37Rv -------------------------------------------TGGTGGV MUL_4367|M.ulcerans_Agy99 -------------------------------------------TGGTG-- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GGAGGQGGTGGAAGAGTGGIQGAGGQGGTGGTGGTGGTGGDGAESTDPSL Mb3541|M.bovis_AF2122/97 --------------------QGNGGNGGNGGTGGKGGTGGAGMNSLDPLL Rv3508|M.tuberculosis_H37Rv --------------------VGAAGKAGIGGTGGQGGAGGAGSAGTDATA MUL_4367|M.ulcerans_Agy99 ------------------------GAAGVAGTGGDGGDGGAGGAGSDASL Mflv_5091|M.gilvum_PYR-GCK ----------------------------AGLPGKAGDAGGAG-------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------AGLPGAAGAAGGAG-------- MSMEG_0868|M.smegmatis_MC2_155 --------------------GGTVDGHAIGGNGGNGGNGSTTAAGGNGGT TH_3810|M.thermoresistible__bu ----------------------------LAGNGGNGGNGYRTTDNN---- MAB_4284c|M.abscessus_ATCC_199 ---------------------------IGSGNTTNTEIGSHNQANIG--- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------------PEPGDDELAYSAVGEEDAESP MMAR_1594|M.marinum_M AGQAGGQG-GTGGTGGAAGQGGTGSVTGAEGSAGDGGTGGLGGDGGTGAD Mb3541|M.bovis_AF2122/97 AAQDGGQG-GTGGTGGNAGAGGTGFTQGADGNAGNGGDGGVGGNGGNGAD Rv3508|M.tuberculosis_H37Rv TGATGGTG-FSGGAGGAGGAGGNTGVGGTNGSGGQGGTGGAGGAGG--AG MUL_4367|M.ulcerans_Agy99 AGQAG----FAGGSGGAGGVGGSAGAGGVNGSGGDGGAGAAGGAGG--AS Mflv_5091|M.gilvum_PYR-GCK ----------AVGAAGAAGTVGTAGATGGTGTGANGGAGGVGGVGG---- Mvan_1264|M.vanbaalenii_PYR-1 ----------AIGTAGVAGAAGTAGATGGTGVGGNGGAGQAGGIGG---- MSMEG_0868|M.smegmatis_MC2_155 GGTGRVIAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGN---- TH_3810|M.thermoresistible__bu -----------------ALDGGHGGN------GGNVGFFSLFNLG----- MAB_4284c|M.abscessus_ATCC_199 ---------TSTSAGGSAAVGGNAGLAGNAGLAGNAGLAGNAGLAG---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 TVVIEKLFLPEDSEPRRRPVLLVGSGLAVVGISAVLALEIALAIG----- MMAR_1594|M.marinum_M NTTTVSAGAQGATGGTGGAGGQGGTGGAAG-TGTGGIQGAGGQGGTGGTG Mb3541|M.bovis_AF2122/97 NTTTAAAGTTGGAGGAGGAGGTGGTGGAAG-TGTGGQQGNGGNGGNGGTG Rv3508|M.tuberculosis_H37Rv GVGADNPTGIGGTGGTGGKGGAGGAGGQGGSSGAGGTNGSGGAGGTGGQG MUL_4367|M.ulcerans_Agy99 AT-------VAGSGGVGGDGGAGGAAG----------------------- Mflv_5091|M.gilvum_PYR-GCK ---------TGAAGAAGGAGGLG--------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------TGAAGAAGQAGTAG--------------------------- MSMEG_0868|M.smegmatis_MC2_155 -NGAVSGTATGGRGGDGIDGGTGGAGGMGE-------------------- TH_3810|M.thermoresistible__bu --------GAGGWGGSGVDG------------------------------ MAB_4284c|M.abscessus_ATCC_199 --------NAGLAGNAGLAGNAG--------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------IRTTGTVALQPTPN--------------------------- MMAR_1594|M.marinum_M GQGGTGGDGAESTDPTLAAQ----AGGQGGTGGTGGAAGQGGTGSTMGAE Mb3541|M.bovis_AF2122/97 GKGGTGGAGMNSLDPLLAAQ----DGGQGGTGGTGGNAGAGGTGFTQGAD Rv3508|M.tuberculosis_H37Rv GAGGAGGAGADNPTGIGGAGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSV MUL_4367|M.ulcerans_Agy99 -----------------------------------------------GGV Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ----------------------------IYSGADGEATGISAGGDGGSAT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GSSGDGGTGGLGGD-GGAGADNTTTVSTGAQGATGGTGGAGGQGGTGGAA Mb3541|M.bovis_AF2122/97 GNAGNGGDGGVGGN-GGNGADNTTTAAAGTTGGAGGAGGAGGTGGTGGAA Rv3508|M.tuberculosis_H37Rv GNAGIGGTGGTGGV-GGAGGAGAAAAAG--SSATGGAGFAGGAGGEGGAG MUL_4367|M.ulcerans_Agy99 GAASLGGDGGHAGA-GGAGGEGLSGGFN--TGAAGGIGGAGGAGGTGGDS Mflv_5091|M.gilvum_PYR-GCK ---ETGTTGGAGGV-GGQGT----------AGGTGGVGGIGGAGSTGAVG Mvan_1264|M.vanbaalenii_PYR-1 ---ETGVTGGVGGI-GGQGT----------EGGTGGVGGVGGVGATGGAG MSMEG_0868|M.smegmatis_MC2_155 GADSLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDA TH_3810|M.thermoresistible__bu -VDVVGGN------------------------------PDGGTPG----- MAB_4284c|M.abscessus_ATCC_199 ----LAGNAGLAGN--------------------AGLAGNAGLAGNAGLA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 QHLIVPTEQAPAPPPVQASAPQPKISVPEPVAAPKPLSPPVAAPLPAAPP MMAR_1594|M.marinum_M G-TGTGGIQGAGGQGGTGGTGGTGGSGGDGTDNSTTPGAAGGAGGQGGTG Mb3541|M.bovis_AF2122/97 G-TGTGGQQGNGGNGGNGGTGGKGGTGG---------------------- Rv3508|M.tuberculosis_H37Rv GNSGVGGTNGSGGAGGAGGKGGTGGAGGSG-------------------- MUL_4367|M.ulcerans_Agy99 G--GVGGVNGDGGAGGGGGRGGDGGSSTS--------------------- Mflv_5091|M.gilvum_PYR-GCK G---VGGKGIQGGQGLQGGKGGDG-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 G---VGGKGIQGGQGLQGGQGGDG-------------------------- MSMEG_0868|M.smegmatis_MC2_155 LVMAAGATGVATGNTAIGGNGGAASANG---------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 G------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 P------------------------------------------------- MMAR_1594|M.marinum_M GTGGAAGSGGTGSTMGAEGSSGDGGTGGLGGDGGEGGQGTTAWNPGDTGG Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M QGASGGAGGTGGTGGAAGTGTGGIQGAGGQGGTGGTGGQGGTGGDGTDNS Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M TTPGAAGGAGGQGGTGGTGGAAGTGGTGSTMGAEGSSGDGGSGGLGGDGG Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M AGGQGTTGTAGAGTGGQGASGGAGGQGGTGGAAGTGTGGIQGAGGQGGTG Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GTGGTGGIGGTGTDSTDPSQIAQAGGQGGTGGTGGAAGQGGTGSTIGSAG Mb3541|M.bovis_AF2122/97 ----------AGMNSLDPLLAAQDGGQGGTGGTGGNAGAGGTGFTQGADG Rv3508|M.tuberculosis_H37Rv -----------ADNPTGAGFAGGAGGTGGAAGAGGAGGATGTGGTGGVVG MUL_4367|M.ulcerans_Agy99 --------------TSGVGGAGGAGGNGGNAGFGVSAGGTG--------- Mflv_5091|M.gilvum_PYR-GCK ----------------------GAGGKGGDADSMGSAGATG--------- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------GTGGTGGDATSMGEAGATG--------- MSMEG_0868|M.smegmatis_MC2_155 ----------------------AVGGNGGFTNIAAIHGSITDSSATSGHG TH_3810|M.thermoresistible__bu -----------------------------------AHG------------ MAB_4284c|M.abscessus_ATCC_199 -----------------------NAGLAGNAGLAGNAGLAG--------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------AAPPLPEAPPIPAAPPVVP--------- MMAR_1594|M.marinum_M TAGDGGTGGLGGDGGTGADNTTTVSAGAQGATGGTGGAGGQGGTGGAAGT Mb3541|M.bovis_AF2122/97 NAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTGGAAGT Rv3508|M.tuberculosis_H37Rv ATGSAGIGGAGGRGGDGGDGASGLGLGLSGFDGGQGGQGGAGGS-----A MUL_4367|M.ulcerans_Agy99 --GSAGDGGAGG-------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --GKGGNGGNGG-------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 --GKGGNGGNGG-------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GAAQGGNGGNGGNGWVQAYDPNG--------------------------P TH_3810|M.thermoresistible__bu ----------------ESHTP----------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GTGGIQGAGGQGGTGGTGGQGGTGGDGADSTDPTLAGQAGGQGGTGGTGG Mb3541|M.bovis_AF2122/97 GTGGQQGNGGNGGNGGTGGKGGTGGDGA------LAGSSGGAGGKGGNGG Rv3508|M.tuberculosis_H37Rv GAGGINGAGGAGGNGGDGGDGATGAAGLGDNG--GVGGDGGAGGAAGNGG MUL_4367|M.ulcerans_Agy99 GAGGVDGVGGASGNGGAAGAGGAGGSGIG------AGIDGGAGGAGGTGG Mflv_5091|M.gilvum_PYR-GCK -RGGLFGKGGNAGNGADGGTGGAG----------------GAGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 -RGSLFGRGGNAGNGGNGGTGGNG----------------GNGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTG---------------GATGGRGGDGA TH_3810|M.thermoresistible__bu -GVYTDRQ-------GEDGEDGTG---------------TGIGGRGGNGG MAB_4284c|M.abscessus_ATCC_199 -NAGLAGNAGLAGNAGLAGNAGLAG----------------NAGLAGNAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -VPVVVPPVPVPVPVRIPVPDPVSPP-----------QLLAPPRLSVPQP MMAR_1594|M.marinum_M AAGQGGTGSTSGSEGSSGDGGTGGLGGDGGAGADNTTTVSAGAQGATGGT Mb3541|M.bovis_AF2122/97 DAGKAGTGSAPGTAGTGGDGGKGGNGGIGAAG--TTGPVGTGASGGTGGS Rv3508|M.tuberculosis_H37Rv NAGVGLT-AKAGDGGAAGNGGNGGAGGAGGAGD-------NNFNGGQGGA MUL_4367|M.ulcerans_Agy99 AAGF------PGGGGTTGAWGTGGAGGAGGAG------------------ Mflv_5091|M.gilvum_PYR-GCK ---------------AGGTGGTGGTGGIGGAG------------------ Mvan_1264|M.vanbaalenii_PYR-1 ---------------NGGTGGTGGTGGIGGAG------------------ MSMEG_0868|M.smegmatis_MC2_155 GASV----WKANGQHSTGQTDTGGNGGRGGDGG----------------- TH_3810|M.thermoresistible__bu ---------SSSGTHPMAE------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GGAGGQGGTGGAAGTGTGGTQGAGGQGGTGGTGGQGGTGGDGTDNSTTPG Mb3541|M.bovis_AF2122/97 GGAGGTGGDGGAAN---GGTAGAGGAGGNGGKGGDGGAG-------VTSS Rv3508|M.tuberculosis_H37Rv GGQGGQGGLGGASTTSINANGGAGGNGGTGGKGGAGGAG----------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------------------TF TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M AAGGAGGQGGTGGTGGAAGQGGTGSTMGSDGSSGDGGTGGLGGDGGEGGQ Mb3541|M.bovis_AF2122/97 TAGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGGD---GGDGAAGAV Rv3508|M.tuberculosis_H37Rv -TLGVGGSGGTGGDGGDAGSGGGGGFGGAAGKAGGGGNGGRGGDGGDGAS MUL_4367|M.ulcerans_Agy99 ---GAGDHGGVGVNPGDSGTAG---------------------------- Mflv_5091|M.gilvum_PYR-GCK ---STGGTGGTGGTGG---------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ---STGGTGGTGGTGG---------------------------------- MSMEG_0868|M.smegmatis_MC2_155 VNAGANGNGGAGGAGGVSEGEGG--------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GTTGTAGAGTGGQGASGGAGGTGGTGGAAGTGTGGIQGAGGQGGTGGTGG Mb3541|M.bovis_AF2122/97 GISGATGAGDGGHGGTGGAGGNGGTGGAGGSGIDGVG--GGTGGTGGNGG Rv3508|M.tuberculosis_H37Rv GLGLGLSGFDGGQGGQGGAGGSAGAGGING-----------AGGAGGNGG MUL_4367|M.ulcerans_Agy99 --------WAGGAGGAGGAGGSAAFNGVNG-----------AGGAGGNGG Mflv_5091|M.gilvum_PYR-GCK ---------TGGTGGTGGTGGTGGTGGTGG-----------KGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 ---------TGGTGGTGGTGGTGGTGGTGG-----------KGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 ------TGGHGGDGGRGGDGALGGNGGTGGVGL-------GNGGKGGNGG TH_3810|M.thermoresistible__bu ----------DGEHVKALDGRPGLDG--------------GNGSHGGNGG MAB_4284c|M.abscessus_ATCC_199 ---------LAGNAGLAGNAAVAGNAAVAG-----------NAAVAGNAA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------VQPPVRVPQPPSPPQVGGTVP-----------QSPPQHQTP MMAR_1594|M.marinum_M QGGTGGDGADSTDPTLAGQAGGQGGTGGTGGAAGQGGTGSVAGTDGSSGD Mb3541|M.bovis_AF2122/97 NGAIGGAGGDAGG---SGNSGGNGGTGGKGGNAGAGG------------- Rv3508|M.tuberculosis_H37Rv DGGDGATGAAGLGD--NGGVGGDGGAGGAAGNGGNAG------------- MUL_4367|M.ulcerans_Agy99 AGGGGGAGASGIG---AGVAGGDGGTGGTGG------------------- Mflv_5091|M.gilvum_PYR-GCK AGG----------------TGGDGGTGGTGG------------------- Mvan_1264|M.vanbaalenii_PYR-1 DGG----------------TGGTGGTGGTGG------------------- MSMEG_0868|M.smegmatis_MC2_155 NGGNGGTYVDPS----HTGAGGNGGNGGAGRIRVNNG------------- TH_3810|M.thermoresistible__bu HGGRGG----------FLGIGGSGGWG----------------------- MAB_4284c|M.abscessus_ATCC_199 VGGVLN----------TGVSGAIGGSSHVGG------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PGEGTP-----------PKPDGPGNYGG---------------------- MMAR_1594|M.marinum_M GGTGGLGGHGGAGADNTTTVSAGAQGATGGTGGAGGTGGTGGAAGTGTGG Mb3541|M.bovis_AF2122/97 --------------------AAGSNGGTVGANGTGGDGGNGGAAGAATAG Rv3508|M.tuberculosis_H37Rv -------------------VGLTAKAGDGGAAGNGGNGGAGGAGGAGDNN MUL_4367|M.ulcerans_Agy99 ------------------------AAGTGGAAGTGGTGGAAGAAGS---- Mflv_5091|M.gilvum_PYR-GCK ---------------------------TGGTGGTGGTGGTGGAG------ Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------TGGTGGTGGTGGTGGAG------ MSMEG_0868|M.smegmatis_MC2_155 ------------------------TATGTATGGNGGNGGNGDAD------ TH_3810|M.thermoresistible__bu --------------------------------GHGGNGGDTDAD------ MAB_4284c|M.abscessus_ATCC_199 -------------------------AINESLGGSGSVGGSTAVGG----- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------------------GHVPTPGAGGSGGSGGGHVP---- MMAR_1594|M.marinum_M IQGAGGQGGTGGTGGQGGTGGDGTDNSTTPGAAGGAGGQGGTGGTGGAAG Mb3541|M.bovis_AF2122/97 SNGGAG--------------------------TGSAGGNGGTGGRGGSGG Rv3508|M.tuberculosis_H37Rv FNGGQG----------------------------GAGGQGGQGGLGGAST MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M QGGTGSTSGSAGSSGDGGTGGLGGDGGEGGQGTTGTAGAGTGGQGASGGA Mb3541|M.bovis_AF2122/97 AGGD-------------GIGGVGG---------------GKGGNGADGEV Rv3508|M.tuberculosis_H37Rv TSIN-----------------------------------ANGGAGGNGGT MUL_4367|M.ulcerans_Agy99 --------------------------------------------AGDGGA Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------DGTGGT Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------DGLGGT MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------------GHRGGK TH_3810|M.thermoresistible__bu --------------------------------------------GGNGGD MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------GAHTGV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------------------------------TPGA MMAR_1594|M.marinum_M GGQGGTGGAAGTGTGGTQGAGGQGGTGGTGGTGGIGGTGTDSTDPSQIAQ Mb3541|M.bovis_AF2122/97 GGAGGAG-----GSGPNTSPGGNGGQG----------------------- Rv3508|M.tuberculosis_H37Rv GGKGGAG---------GAGTLGVGGSG----------------------- MUL_4367|M.ulcerans_Agy99 GGAGGAG---------DDGSAGVVS------------------------- Mflv_5091|M.gilvum_PYR-GCK GGTGGTG------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTG------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGDGGEA------------------------------------------- TH_3810|M.thermoresistible__bu GGNGG--------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGGVSTG------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GGSGGSG------------------------------------------- MMAR_1594|M.marinum_M AGGQGGTGGTGGAAGQGGTGSTMGSAGTAGDGGTGGLGGHGGTGADNTTT Mb3541|M.bovis_AF2122/97 --GQGGSGGAGGAAGAGGAGG--GANGTAGNGGQG--------------- Rv3508|M.tuberculosis_H37Rv -----GTGGDGGDAGSGGGGGFGGAAGKAGGGGNGGVGGD---------- MUL_4367|M.ulcerans_Agy99 -----------GDPG---------TAGKAGGAG----------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M VSAGAQGATGGTGGAGGQGGTGGAAGTGTGGTQGAGGQGGTGGTGGQGGT Mb3541|M.bovis_AF2122/97 -------------GAGGTGGAGAASSATNGGSGGAGGTGGAGGTGGAGGD Rv3508|M.tuberculosis_H37Rv -------------GGEGASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGA MUL_4367|M.ulcerans_Agy99 ---------------------------------GAGGVGGNGVAGGVNGS Mflv_5091|M.gilvum_PYR-GCK ---------------------------------GQGGQGGQGGTGGTGGQ Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------GFGGQGGQGGTGGTGGQ MSMEG_0868|M.smegmatis_MC2_155 ----------------------LIRATVIGSNASGTATGGDGGNGGTLGA TH_3810|M.thermoresistible__bu -------------------------------------SAGRGGTGGLRGV MAB_4284c|M.abscessus_ATCC_199 -----------------------------------VGVGSHVGGGISESL MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------------------------------GGHVPTPG---- MMAR_1594|M.marinum_M GGTGTDSTDPTLVGQAGGQGGTGGTGGAAGQGGTGSVTGAEGSAGDGGSG Mb3541|M.bovis_AF2122/97 G-----------VGGAGG--GNGGHGGDAGDGGN---------------- Rv3508|M.tuberculosis_H37Rv G-------------------GAGGTGGAGGDGAPATLIG----------- MUL_4367|M.ulcerans_Agy99 G-------------------GAGGAG------------------------ Mflv_5091|M.gilvum_PYR-GCK G-------------------GLGGGG------------------------ Mvan_1264|M.vanbaalenii_PYR-1 G-------------------GLGGVG------------------------ MSMEG_0868|M.smegmatis_MC2_155 TN------------------GTGGAATIVAYNVV---------------- TH_3810|M.thermoresistible__bu F------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 G------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GLGGHGGTGADNTTAVSAGAQGATGGTGGAGGQGGTGGAAGTGTGGIQGA Mb3541|M.bovis_AF2122/97 ------GANGNNRSSGSFLAAGGTGGAAGDGGQGGQGGAGG-------GA Rv3508|M.tuberculosis_H37Rv --GPDGGDGGQGGIGGDGGNAGFGAGVPGDGGDGGNAGFGA-GVPGDGGI MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GGQGGTGGTGGQGGTGGTGTDSTDPTLAGQAGGQGGTGGTGGAAGSGGTG Mb3541|M.bovis_AF2122/97 GGQGGAGGAGGTGGNGGN--------------ITGGTAGTAGAAGNG--- Rv3508|M.tuberculosis_H37Rv GGTGGAGGAGGAGADGDPS-------------IDGGQGGAGGHGGQGGKG MUL_4367|M.ulcerans_Agy99 ----GAGGTGGAGASGVP-------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----GTGGQGGTG------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----GTGGTGGTG------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ---QANPQASGTATDGHG-------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M STMGAEGSSGDGGTGGLGGDGGTGGQGTTAVNPGDTGGQGASGGAGGTGG Mb3541|M.bovis_AF2122/97 ---------GAAGKGGAGGQGGTGG------------------------- Rv3508|M.tuberculosis_H37Rv GLNSTGLASAASGDGGNGGAGGAGGN------------------------ MUL_4367|M.ulcerans_Agy99 ----------ASVDGGDGGAGGAGG------------------------- Mflv_5091|M.gilvum_PYR-GCK ------------GTGGQGGTGGTGG------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------GTGGQGGTGGTGG------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------GSGINGGHGGNGG------------------------- TH_3810|M.thermoresistible__bu --------------GINGGNGR---------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------GSGSVGGSTAVGG------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------TGGPGGTGGSGG------------------------- MMAR_1594|M.marinum_M TGGAAGTGTGGTQGAGGQGGTGGTGGQGGTGGDGTDNSTTPGAAGGAGGQ Mb3541|M.bovis_AF2122/97 -------GTGGQGGAGGDGGAGGTGGDRTVGG-----GTVP---AGSGGQ Rv3508|M.tuberculosis_H37Rv -------GGDGDGFIGGSGGTGGTGGDAGVGG-----------LANTGGT MUL_4367|M.ulcerans_Agy99 -----------------AAGTGGSG-----------------------GS Mflv_5091|M.gilvum_PYR-GCK -----------------TGGTGGTG-----------------------GA Mvan_1264|M.vanbaalenii_PYR-1 -----------------TGGTGGTG-----------------------GA MSMEG_0868|M.smegmatis_MC2_155 -----------------QGTIEANGPSAVASG---------------IGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------GAHTGVG------------------------G MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------------------------------------GH MMAR_1594|M.marinum_M GGTGGTGGAAGSGGTGSTMGAEGSSGDGGTGGLGGDGGTGGQGTTAVNPG Mb3541|M.bovis_AF2122/97 GGNAGGGGAGGQGG-----------ADGGSGGDGGDAGTGGN-------- Rv3508|M.tuberculosis_H37Rv AGNAGIGGAGGRGG------------DGGAGDSGALSQDGNG-------- MUL_4367|M.ulcerans_Agy99 AGNTGAGGAGGAGG------------AGGSAASTGVNGDG---------- Mflv_5091|M.gilvum_PYR-GCK GGDGGLGGLGGFGG------------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 GGDGGLGGLGGFGG------------------------------------ MSMEG_0868|M.smegmatis_MC2_155 GGNGGDGIDGGLGG------------------------------------ TH_3810|M.thermoresistible__bu ---------AGLGG------------------------------------ MAB_4284c|M.abscessus_ATCC_199 GVSTGVGVGSHVGG------------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VPTPGAGTPGGSGG------------------------------------ MMAR_1594|M.marinum_M DTGGQGASGGAGGTGGTGGAAGTGTGGTQGAGGQGGTGGTGGQGGTGGDG Mb3541|M.bovis_AF2122/97 --------------GGNGGNRNSGNG-TGGAGGNGGGGANGGAGGAGGSG Rv3508|M.tuberculosis_H37Rv --------------FAGGQGGQGGVGGNAGAGGINGAGGTGGTGGAGGDG MUL_4367|M.ulcerans_Agy99 -----------------------------------GAGGAGGVGGLGGDS Mflv_5091|M.gilvum_PYR-GCK ------------------------------------SGGTGGQGGLGGPG Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------VGGTGGQGGQGGPG MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------NGGDGVVNTTANAA TH_3810|M.thermoresistible__bu ------------------------------------RGXX---------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------GISESLGGSGSVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------------------------------GHLPFPGAGSTP MMAR_1594|M.marinum_M TDNSTTPGAAGGAGGQGGTGGTGGAAGSGGTGSTMGAEGSSGDGGTGGLG Mb3541|M.bovis_AF2122/97 ----------GGTGGNGGAGGDAGDAGNGGNGNGTGNGGNGGNGGIAGMG Rv3508|M.tuberculosis_H37Rv QNGTTGVASEGGAGGQGGDGGQGGIGGAG--GNAGFGAGVPGDGGIGGTG MUL_4367|M.ulcerans_Agy99 -------AATAGGGGAGGDGGKGGAGGAG--VNGVGG----GDGGKGGTG Mflv_5091|M.gilvum_PYR-GCK ----------GSTGGAGGAGGQAGTAGKG--------------GLFGGSG Mvan_1264|M.vanbaalenii_PYR-1 ----------GSTGGAGGAGGQAGVAGKG--------------GLFGGSG MSMEG_0868|M.smegmatis_MC2_155 NPGSA--TGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTA TH_3810|M.thermoresistible__bu --------------XXGGGVGAAVRSGNG----VFSGGG--------GTP MAB_4284c|M.abscessus_ATCC_199 ---------GSTAVGGGAHTGVGGGVNTG-----------------VGVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------GGSGGGHLPTPGAGTPG-----------------GGLG MMAR_1594|M.marinum_M GAGGTGGQGTTAVNPGDTGGQGASGGAGGTGGTGGAAGTGTGGIQGAGGQ Mb3541|M.bovis_AF2122/97 GNGGAG------------------------------TGSGNGGNGGSGGN Rv3508|M.tuberculosis_H37Rv GAGGAG------------------------------GAGADGDPSIDGGQ MUL_4367|M.ulcerans_Agy99 GAGGAG------------------------------GAGSDGIIPSNGGL Mflv_5091|M.gilvum_PYR-GCK SAGKAG------------------------------ATGAAGASGGKGAQ Mvan_1264|M.vanbaalenii_PYR-1 SAGTAG------------------------------VTGASGASGGKGAQ MSMEG_0868|M.smegmatis_MC2_155 TAGKGG-------------------------------EASNGGVAGNGGN TH_3810|M.thermoresistible__bu SAGFGV-------------------------------PTT---IQFPAGS MAB_4284c|M.abscessus_ATCC_199 SHVGGG------------------------------ISESLGGSGSVGGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GFGGGH------------------------------APAPGGGLGGGGGH MMAR_1594|M.marinum_M GGTGGAGGSGGTGGDGTDNSTTPGAAGGAGGQGGTGGTGGAAGSGGTGST Mb3541|M.bovis_AF2122/97 GGNAGMGGNSGTG------------------------------------- Rv3508|M.tuberculosis_H37Rv GGAGGHGGQGGKG------------------------------------- MUL_4367|M.ulcerans_Agy99 GGNGGNGGNGGQ-------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GATGAQGATGAQG------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GATGAQGATGAQG------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ALVMAAGTTGVAT------------------------------------- TH_3810|M.thermoresistible__bu CTSRAVSREGIMP------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TAVGGGAHTSAIN------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 APAPGGGLGGFGG------------------------------------- MMAR_1594|M.marinum_M MGAEGSSGDGGTGGLGGAGGTGGQGTTAVNPGDTGGQGASGGAGGTGGTG Mb3541|M.bovis_AF2122/97 ------SGDGGAGGNGGAAGTGG----------------------TGGDG Rv3508|M.tuberculosis_H37Rv -------GLNSTGLASAASGDGG----------------------NGGAG MUL_4367|M.ulcerans_Agy99 -----------------AFGDG---------------------------- Mflv_5091|M.gilvum_PYR-GCK -----------------ATGATG--------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------------ATGATG--------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------GNTATGGDGG--------------------------- TH_3810|M.thermoresistible__bu -------------SSRAASARAG--------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GAAGTGTGGIQGAGGQGGTGGTGGQGGTGGDGAESTDPTLAGQAGGQGGT Mb3541|M.bovis_AF2122/97 GLTGTG-----GTGGSGGTGGDGGNGGNGGNGADNTAN-MTAQAGGDGGN Rv3508|M.tuberculosis_H37Rv GAGGNGGDGDGFIGGSGGTGGTGGDAGVGGLANTGGTAGNAGIGGAG--- MUL_4367|M.ulcerans_Agy99 ------------VGGAGGIGGKGGNAAIGTIVING--------------- Mflv_5091|M.gilvum_PYR-GCK ------------AAGKAGATGAAGAAGAAG-------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------ASGAQGSAGSAGSAGVAG-------------------- MSMEG_0868|M.smegmatis_MC2_155 -----------AATTAGATGGAGGFSNIAAIHGAITDS------------ TH_3810|M.thermoresistible__bu -----------AACASSTSRSRRSFCCSRA-------------------- MAB_4284c|M.abscessus_ATCC_199 -------------DALGGSGSVGGSTAVGG-------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------GHSGGGLGGLGGGHK----------------------- MMAR_1594|M.marinum_M GGTGGAAGQGGTGSVAGTDGSAGDGGTGGLGGHGGAGADNTTTVSAGAQG Mb3541|M.bovis_AF2122/97 G---------------------GDGGFG---------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M ATGGTGGAGGQGGTGGAAGTGTGGTQGAGGQGGTGGTGGTGGIGGTGTDS Mb3541|M.bovis_AF2122/97 ---GGAGAGGGGLTAGANGT--------GGQGGAGGDGGNGAIGGHGPLT Rv3508|M.tuberculosis_H37Rv ---GRGGDGGAGDSGALSQDGNGFAGGQGGQGGVGGNAGAGGINGAG--- MUL_4367|M.ulcerans_Agy99 -----------------------------------------GVGGAG--- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ----------------------------------------TAISGHGG-- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M TDPSQIAQAGGQGGTGGTGGAAGQGGTGSTMGSAGTAGDGGTGGLGGGGG Mb3541|M.bovis_AF2122/97 DDP------GGNGGTGGNGGTGGTGGAG-------------IGSLGGG-- Rv3508|M.tuberculosis_H37Rv ----------GTGGTGGAGGDGQNGTTG---------------------- MUL_4367|M.ulcerans_Agy99 ----------GSGGLGGATEDG---------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------SAGTTGAQGSAG---------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------SAGTTGAQGSAG---------------------------- MSMEG_0868|M.smegmatis_MC2_155 ---------AGNGGNGGKGADGWVQAYDP--------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M TGADNTTAVSAGAQGATGGTGGAGGQGGTGGAAGTGTGGIQGAGGQGGTG Mb3541|M.bovis_AF2122/97 -------------------TGGDGGNGGTG--------------GNGGTG Rv3508|M.tuberculosis_H37Rv ----------------VASEGGAGGQGGDG--------------GQGGIG MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GTGGTGGIGGTGTDSTDPTLAGQAGGQGGTGGTGGAAGTGGTGSVTGTDG Mb3541|M.bovis_AF2122/97 GEGGE---------------------VGGAGGTGGAAGNG---------- Rv3508|M.tuberculosis_H37Rv GAGGNAGFGA------------GVPGDGGIGGTGGAGGAGGAGADGDPSI MUL_4367|M.ulcerans_Agy99 -----------------------------VGGVGCAGGAG---------- Mflv_5091|M.gilvum_PYR-GCK -----------------------------TNGANGANGSQ---------- Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------TNGANGANGSQ---------- MSMEG_0868|M.smegmatis_MC2_155 -----------------------------AGPVGSKIANSS--------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M TAGDGGTGGLGGHGGAGADNTTTVSAGAQGATGGTGGAGGTGGTGGAAGT Mb3541|M.bovis_AF2122/97 --GDGGTGGTG---------------------GGDGGAGGTGGTG----- Rv3508|M.tuberculosis_H37Rv DGGQGGAGGHG----------------------GQGGKGGLNSTG----- MUL_4367|M.ulcerans_Agy99 ---------------------------------GNGGRGDMLFT------ Mflv_5091|M.gilvum_PYR-GCK -----------------------------------GAAGKAGATG----- Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------GAAGKAGATG----- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------AVAGNGGDGGVNGTG----- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GTGGTQGAGGQGGTGGTGGTGGIGGTGTDSTDPSQIAQAGGQGGTGGTGG Mb3541|M.bovis_AF2122/97 ------------------GTGGLG-------DP-RVGGSGGDGGTGGSGG Rv3508|M.tuberculosis_H37Rv ----------------------------------LASAASGDGGNGGAGG MUL_4367|M.ulcerans_Agy99 --------------------------------------------VGGSGG Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------TTGATG Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------TTGATG MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------------------GASGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------------GAHTS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M AAGSGGTGSVTGTDGTAGDGGTGGLGGDGGAGADNTTTVSAGAQGATGGT Mb3541|M.bovis_AF2122/97 AAGNGGN----------------------------------------GGN Rv3508|M.tuberculosis_H37Rv AGGNGGA----------------------------------------GGL MUL_4367|M.ulcerans_Agy99 TGGDGGG----------------------------------------GGS Mflv_5091|M.gilvum_PYR-GCK AAGEDGD----------------------------------------AGS Mvan_1264|M.vanbaalenii_PYR-1 AAGDAGD----------------------------------------PGS MSMEG_0868|M.smegmatis_MC2_155 DGGNGGNTS----------------------------------VWKSGGQ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AINESMN------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GGAGGQGGTGGAAGTGTGGIQGAGGQGGTGGAGGSGGTGGDGTDNSTTPG Mb3541|M.bovis_AF2122/97 AGAGGNG------------------NGGTGGAGGIGGTGGNGGD--AEPG Rv3508|M.tuberculosis_H37Rv GGGGGTGG-----------------TNGNGGLGGGGGNGGAGGA-----G MUL_4367|M.ulcerans_Agy99 ASGSGTGG-----------------SGGTGGVGGIGGDGKLG-------- Mflv_5091|M.gilvum_PYR-GCK GGSGINGG-----------------AGGAGGAGGEGGEGGDG-------- Mvan_1264|M.vanbaalenii_PYR-1 EAVDINGG-----------------AGGAGGAGGEGGEGGAG-------- MSMEG_0868|M.smegmatis_MC2_155 TADGEHN------------------TGGNGGNGGDGSEPGPGGN------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------SSINASHSSSMNESFGSS------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M AAGGAGGQGGTGGTGGAAGQGGTGSTMGSDGSSGDGGTGGLGGDGGGAGQ Mb3541|M.bovis_AF2122/97 VPPGAGGAGGAGTTGGKGGTGGNGSGTGSGGTGGDGGTGGGGGNGG---- Rv3508|M.tuberculosis_H37Rv GTPTGSGTEGTGGDGGDAGAGGNGGSATGVGNGGNGGDGGNGGDGG---- MUL_4367|M.ulcerans_Agy99 ---------------------------------GFGGDGGDGGDGG---- Mflv_5091|M.gilvum_PYR-GCK ---------------------------------GKGGAGAEGGAGG---- Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------GAGGDGSEGGAGG---- MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------GAGGAGGNGGTGG---- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------MGSHGAAGTGFEAQG--- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GTTGTAGAGTGGQGASGGAGGQGGTGGAAGTGTGGTQGAGGQGGTGGTGG Mb3541|M.bovis_AF2122/97 ---------------TGWNGGKGDTGSGGGAGDGGKAPAGGTGGAGGDGG Rv3508|M.tuberculosis_H37Rv ---------------NGAPGGFG-----GGAGAGGLGGSGAGGGTDGDDG MUL_4367|M.ulcerans_Agy99 ---------------FGVIGGQG-----GGGGFGGLGGTGAGG-APSDKG Mflv_5091|M.gilvum_PYR-GCK ---------------GGGAGGSG------AGGAGGAGGSGGSGGSGGSGG Mvan_1264|M.vanbaalenii_PYR-1 ---------------SGGAGGSG------TGGAGGAGGSGGSGGSGGAGG MSMEG_0868|M.smegmatis_MC2_155 ----------------TTAGGSG---------NGGNGGNGGNGGADGTPG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------HAQGHASETAHTTLPGAEHH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M TGGTGGTGTDSTDPSQIAQAGGQGGTGGTGGAAGQGGTGSTMGAEGSSGD Mb3541|M.bovis_AF2122/97 -------------------AGGKGGSGGV--------------------- Rv3508|M.tuberculosis_H37Rv -------------------NGGSPGTDGS--------------------- MUL_4367|M.ulcerans_Agy99 -------------------INGEPGNPG---------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------SGGAAGDSDD--------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------SGGAAGDSD---------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------TAGTTGANNP--------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GGTGGLGGHGGAGADNTTTVSAGAQGATGGTGGAGGQGGTGGAAGTGTGG Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M TQGAGGQGGTGGTGGTGGIGGTGTDSTDPSQIAQAGGQGGTGGTGGAAGQ Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GGTGSTMGSAGTAGDGGTGGLGGGGGTGADNTTTVSAGAQGATGGTGGAG Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GQGGTGGAAGTGTGGIQGAGGQGGTGGTGGTGGIGGTGTDSTDPTLAGQA Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1594|M.marinum_M GGQGGTGETGGAAGSGGTGS Mb3541|M.bovis_AF2122/97 -------------------- Rv3508|M.tuberculosis_H37Rv -------------------- MUL_4367|M.ulcerans_Agy99 -------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------- TH_3810|M.thermoresistible__bu -------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------- MLBr_01183|M.leprae_Br4923 -------------------- MAV_4827|M.avium_104 --------------------