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M. bovis AF2122 / 97 Mb0896c (PE_PGRS15)

annotation: PE-PGRS family protein
coordinates: 968884 - 970710
length: 608

MSYVLATPEMVAAAANNLAQIGSTLSAANAAALAPTTGVLAAGADEVSAAVASLFSGHAQAYQTLGTQAA
AFHERFIQALSTAAGAYGSAEAANASPLQQALNVINAPTQTLLGRPLIGNGTNGAPGTGQAGGPGGLLYG
NGGNGGSGGVGQAGGAGGSAGLIGIGGTGGAGGAGAVGGVGGNGGWLYGNGGAGGLGGTGVAGVNGGMGA
AGGAGGNAYLFGSGGAGGQGGMGAAGADGVNPTPTGTADAGSTGTDQTLGGNAIGGNGGPGDAGDAMTSG
GAGGSGGNAVSTVNGDAVGGEGGKGGEGAYGGAGGAGGSAASIGNAAIGGNGGAGGNAQAPGGVGGAGGE
GGDAQVGTNSPSNAEAGNGGSGGNGFDSFASGGTGGAGGTGGAGGRGGLLIGDGGAGGAGGVGGTGGSGA
PGGGGAGGDGGAANTDSAGSSRKAFGGDGGVGGDGASALGTGGEGGIGGQGGNGGAGGLLIGNGGAGGVG
GTAGAGGTGGSGGAGGAGGAGGGGTNSGPGAAFGGNGNTGGNGGNGGAPGALGGKGGSGGLIGRAGSDGG
VGAGGAGGAGGAGGTGGEGGTGGDGKTTDGNPGMGGSPGSAGQPGQPG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0896cPE_PGRS15-100% (608)PE-PGRS family protein
M. bovis AF2122 / 97Mb2878PE_PGRS480.065.11% (622) PE-PGRS family protein
M. bovis AF2122 / 97Mb2667cPE_PGRS460.049.02% (763) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_5091-1e-11849.91% (537) triple helix repeat-containing collagen
M. tuberculosis H37RvRv0872cPE_PGRS150.099.83% (606) PE-PGRS family protein
M. leprae Br4923MLBr_01183-6e-1439.58% (96) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-3e-5032.38% (522) hypothetical protein MAB_4284c
M. marinum MMMAR_2490-0.058.79% (626) PE-PGRS family protein, PE_PGRS15_1
M. avium 104MAV_4827-7e-2338.42% (190) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-3e-9441.63% (615) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-2e-3938.72% (297) PUTATIVE -
M. ulcerans Agy99MUL_0572-1e-15946.41% (765) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-1e-11343.67% (577) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


Mb0896c|M.bovis_AF2122/97           --------------------------------------------------
Rv0872c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_2490|M.marinum_M               --------------------------------------------------
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MUL_0572|M.ulcerans_Agy99           --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

Mb0896c|M.bovis_AF2122/97           --------MSYVLATPEMVAAAANNLAQIGSTLSAANAAALAPTTGVLAA
Rv0872c|M.tuberculosis_H37Rv        --------MSYVLATPEMVAAAANNLAQIGSTLSAANAAALAPTTGVLAA
MMAR_2490|M.marinum_M               --------MSFVITAPELISAAATDLAGIGSTISAANAAASASTTAVAAA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MUL_0572|M.ulcerans_Agy99           --------MSYVVAIPDMLASAAADVAGIGSSVGAANTAAVGATTGVMAA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVG
MAV_4827|M.avium_104                ----MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAATAS
                                                                                      

Mb0896c|M.bovis_AF2122/97           GADEVSAAVASLFSGHAQAYQTLGTQAAAFHERFIQALSTAAGAYGSAEA
Rv0872c|M.tuberculosis_H37Rv        GADEVSAAVASLFSGHAQAYQTLGTQAAAFHERFIQALSTAAGAYGSAEA
MMAR_2490|M.marinum_M               AADEVSTAVATLFGAHAQQYQSLGSQMAAFHDDFVRILASGSNLYATAEA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MUL_0572|M.ulcerans_Agy99           ADDEVSVAIAALFSGHGQAYQAISAQAAAFHDQFLRALTGAGGAYAAAEA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSP
MAV_4827|M.avium_104                APDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDN
                                                                                      

Mb0896c|M.bovis_AF2122/97           AN-------------------------------------ASPLQQALNVI
Rv0872c|M.tuberculosis_H37Rv        AN-------------------------------------ASPLQQALNVI
MMAR_2490|M.marinum_M               TN-------------------------------------ASPLQPLLDLI
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MUL_0572|M.ulcerans_Agy99           AN-------------------------------------ASPLQAAEQEV
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SL-------------------------------------LSPRDNDFLSH
MAV_4827|M.avium_104                VMLVS-----------------------------------AFLAAAALAQ
                                                                                      

Mb0896c|M.bovis_AF2122/97           N---------------------APTQTLLG--------RPLIGNGTNGAP
Rv0872c|M.tuberculosis_H37Rv        N---------------------APTQTLLG--------RPLIGNGTNGAP
MMAR_2490|M.marinum_M               N---------------------APTQAILG--------RPLIGNGSNGTY
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MUL_0572|M.ulcerans_Agy99           LAVIN-----------------APTNALLG--------RPLIGNGTDGLA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      N---------------------DTDFASHN--------PIASGNQVMSPS
MAV_4827|M.avium_104                N-----------------------VGGAMG----------YERTAVLLVE
                                                                                      

Mb0896c|M.bovis_AF2122/97           GTGQAGGPGGLLYGNGGNGGSGGVG-QAGGAGGSAGLIG-IGGTGGAGGA
Rv0872c|M.tuberculosis_H37Rv        GTGQAGGPGGLLYGNGGNGGSGGVG-QAGGAGGSAGLIG-IGGTGGAGGA
MMAR_2490|M.marinum_M               -PGQDGRDGGLLIGNGGNGAAGDFG-QAGGGGGSAGLFG-DGGNGGTGGA
TH_3810|M.thermoresistible__bu      -------------------------------------------------V
Mflv_5091|M.gilvum_PYR-GCK          QN------GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG
Mvan_1264|M.vanbaalenii_PYR-1       QN------GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG
MSMEG_0868|M.smegmatis_MC2_155      DNPNGG-TGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA
MUL_0572|M.ulcerans_Agy99           GTGAAGGAGGLLWGNGGNGG-SGAAGQAGGAGGAAGLIGTGGAGGMGGAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDG--AVAVGGSNSGPIASGQ
MAV_4827|M.avium_104                PDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAGLEKLESLP
                                                                                      

Mb0896c|M.bovis_AF2122/97           GAVGGVGGNGG--WLYGNGGAGGLGGTGVAGVNGGMG----AAGGAGGNA
Rv0872c|M.tuberculosis_H37Rv        GAVGGVGGNGG--WLYGNGGAGGLGGTGVAGVNGGMG----AAGGAGGNA
MMAR_2490|M.marinum_M               GSAGGNGGTGG--LLFGNGGNGGMGGTATLGFNGGMA----GAGGNGGSA
TH_3810|M.thermoresistible__bu      DGDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGGGT
Mflv_5091|M.gilvum_PYR-GCK          GGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGAT
Mvan_1264|M.vanbaalenii_PYR-1       SGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGAT
MSMEG_0868|M.smegmatis_MC2_155      GLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGT
MUL_0572|M.ulcerans_Agy99           GGAGGMGGSGG--WLLGNGGAGGAGGVGCAGVSGGVG----GTGGNAMLF
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GSTAVNGDVRD--SNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSADID
MAV_4827|M.avium_104                GGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPETALARGAALAAANAPL
                                                                                      

Mb0896c|M.bovis_AF2122/97           YLFG------------------SGGAGGQGGMGAAG--------------
Rv0872c|M.tuberculosis_H37Rv        YLFG------------------SGGAGGQGGMGAAG--------------
MMAR_2490|M.marinum_M               LLFG------------------SGGAGGQGGTGVAG--------------
TH_3810|M.thermoresistible__bu      GIIS--------------------LLSLAGNGGNGG--------------
Mflv_5091|M.gilvum_PYR-GCK          GVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------
Mvan_1264|M.vanbaalenii_PYR-1       GVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------
MSMEG_0868|M.smegmatis_MC2_155      GGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNV
MUL_0572|M.ulcerans_Agy99           GNGGAGGMGGAGADGAVGAAGTAGTSTSAGGVGGAG------------WD
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      KSVTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTN-------------T
MAV_4827|M.avium_104                FASS------------------TAALAYAQDPGTGAVD------------
                                                                                      

Mb0896c|M.bovis_AF2122/97           ADGVNPTPTGTADAGSTG--------------------------------
Rv0872c|M.tuberculosis_H37Rv        ADGVNPTPTGTADAGSTG--------------------------------
MMAR_2490|M.marinum_M               TNGSNPLVFDTANPGAAG--------------------------------
TH_3810|M.thermoresistible__bu      -NGYRTTDNNALDGGHGG--------------------------------
Mflv_5091|M.gilvum_PYR-GCK          AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG---------------
Mvan_1264|M.vanbaalenii_PYR-1       AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG---------------
MSMEG_0868|M.smegmatis_MC2_155      TVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDG
MUL_0572|M.ulcerans_Agy99           ATAAGVLAATGGDGGDSGGGGAGGNGGAGGAGGHG--------------S
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      EIGSHNQANIGTSTSAGG--------------------------------
MAV_4827|M.avium_104                QYSLPDYLYVPVDPEPGD--------------------------------
                                                                                      

Mb0896c|M.bovis_AF2122/97           --------------------------------------------------
Rv0872c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_2490|M.marinum_M               --------------------------------------------------
TH_3810|M.thermoresistible__bu      -------------------------------------------NGGNV-G
Mflv_5091|M.gilvum_PYR-GCK          -AVGAAGAAG------TVGTAGATGGTG---------------TGANG-G
Mvan_1264|M.vanbaalenii_PYR-1       -AIGTAGVAG------AAGTAGATGGTG---------------VGGNG-G
MSMEG_0868|M.smegmatis_MC2_155      HAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDG-G
MUL_0572|M.ulcerans_Agy99           ALFGADGANGNGGAGGAGGNPGAPGNGG---------------TGGVGPD
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                -------------------------------------------------D
                                                                                      

Mb0896c|M.bovis_AF2122/97           --TDQTLGGN------------------AIGGNGGPGDAG----------
Rv0872c|M.tuberculosis_H37Rv        --TDQTLGGN------------------AIGGNGGPGDAG----------
MMAR_2490|M.marinum_M               --QDVTTTDDPAANP-------------LTGGNGSEGAAG----------
TH_3810|M.thermoresistible__bu      FFSLFNLGG--------------------AGGWGGSGVDG----------
Mflv_5091|M.gilvum_PYR-GCK          AGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGG
Mvan_1264|M.vanbaalenii_PYR-1       AGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGG
MSMEG_0868|M.smegmatis_MC2_155      HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGE
MUL_0572|M.ulcerans_Agy99           AATSGGMGGTGGDPG-------------AVGGRGNSGAAGGAGAVAGASG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---SAAVGGN-------------------AGLAGNAGLAG----------
MAV_4827|M.avium_104                ELAYSAVGEE--------------------DAESPTVVIEKLFLPEDSEP
                                                                                      

Mb0896c|M.bovis_AF2122/97           ----DAMTSGGAGGSGGNAVSTVNGDAVG---------------------
Rv0872c|M.tuberculosis_H37Rv        ----DAMTSGGAGGSGGNAVSTVNGDAVG---------------------
MMAR_2490|M.marinum_M               ----STIQNGGVGGQGGSATSTNQNSALG---------------------
TH_3810|M.thermoresistible__bu      -----------VDVVGGNP-------------------------------
Mflv_5091|M.gilvum_PYR-GCK          Q--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG---------
Mvan_1264|M.vanbaalenii_PYR-1       Q--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG---------
MSMEG_0868|M.smegmatis_MC2_155      IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASG
MUL_0572|M.ulcerans_Agy99           AAGTIIAGNGGNGGAGGAGYAADGPAGPAIGNG--GDGGHG---------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----NAGLAGNAGLAGNAGLAGNAGLAGNAG-------------------
MAV_4827|M.avium_104                RRRPVLLVGSGLAVVGISAVLALEIALAIG--------------------
                                                                                      

Mb0896c|M.bovis_AF2122/97           ----------GEGGKGGEG----------------------------AYG
Rv0872c|M.tuberculosis_H37Rv        ----------GEGGKGGEG----------------------------AYG
MMAR_2490|M.marinum_M               ----------GEGGKGGDG----------------------------ANG
TH_3810|M.thermoresistible__bu      -----------DGGTPG------------------------------AHG
Mflv_5091|M.gilvum_PYR-GCK          ----LQGGKGGDGGAGGKGGDADSMGS------------------AGATG
Mvan_1264|M.vanbaalenii_PYR-1       ----LQGGQGGDGGTGGTGGDATSMGE------------------AGATG
MSMEG_0868|M.smegmatis_MC2_155      TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANG
MUL_0572|M.ulcerans_Agy99           ----GAGGFYGNGGAGGAGGNSAP---------------------GGGTG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------LAGNAGLAGNAG-------------------------LAGNA
MAV_4827|M.avium_104                ---------IRTTGTVALQPTPN-------------------QHLIVPTE
                                                                                      

Mb0896c|M.bovis_AF2122/97           GAGGAGGSAASIGN------------------------------------
Rv0872c|M.tuberculosis_H37Rv        GAGGAGGSAASIGN------------------------------------
MMAR_2490|M.marinum_M               GMGGNGGSGDTSGQTD----------------------------------
TH_3810|M.thermoresistible__bu      ESHTPGVYTDRQ--------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GKGGNGGNGGRGGLFG---------------KGGNAGNGAD---------
Mvan_1264|M.vanbaalenii_PYR-1       GKGGNGGNGGRGSLFG---------------RGGNAGNGGN---------
MSMEG_0868|M.smegmatis_MC2_155      AVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN
MUL_0572|M.ulcerans_Agy99           GNGGTGGDSGAMGSSG--------------GRGGDGGVGTNG--------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GLAGNAGLAGNAGLAG----------------------------------
MAV_4827|M.avium_104                QAPAPPPVQASAPQPK----------------------------------
                                                                                      

Mb0896c|M.bovis_AF2122/97           ----------------AAIGGNGGAGGNAQAPGGVGG-------------
Rv0872c|M.tuberculosis_H37Rv        ----------------AAIGGNGGAGGNAQAPGGVGG-------------
MMAR_2490|M.marinum_M               ------------APQPSATGGNGGNGGDAQVAGGAGG-------------
TH_3810|M.thermoresistible__bu      -----------------GEDGEDGTGTGIGGRGGNGG-------------
Mflv_5091|M.gilvum_PYR-GCK          -------------GGTGGAGGAGGTGG-TGGAGGTGG-------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------GGTGGNGGNGGTGG-TGGNGGTGG-------------
MSMEG_0868|M.smegmatis_MC2_155      GPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHST
MUL_0572|M.ulcerans_Agy99           -----------GAGGGGGNATSYGTANATGGAGGDGG-------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------NAGLAGNAGLAGNAGLAGNAGLAGN-------------
MAV_4827|M.avium_104                ------------ISVPEPVAAPKPLSPPVAAPLPAAP-------------
                                                                                      

Mb0896c|M.bovis_AF2122/97           ----AGGEGGDAQVGTNSPSNAEAGNGGSGGNGFDSFASGGTGGAGGTGG
Rv0872c|M.tuberculosis_H37Rv        ----AGGEGGDAQVGTNSPSNAEAGNGGSGGNGFDSFASGGTGGAGGTGG
MMAR_2490|M.marinum_M               ----AGGWGGDGHANQ---GDAVGGVGGRGGAGFASSAAGGAGGTGGTGG
TH_3810|M.thermoresistible__bu      ---SSSGTHPMAEDG--------EHVKALDGRPGLD---GGNGSHGGNGG
Mflv_5091|M.gilvum_PYR-GCK          ----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1       ----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155      GQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGG
MUL_0572|M.ulcerans_Agy99           --TGSTGNGGSGGDGGN----GGTGHGGGGGPGGTAINYGAGDAFGGAAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --AGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAAVAGNAAVAGNAAVAGN
MAV_4827|M.avium_104                ----PPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPP
                                                                                      

Mb0896c|M.bovis_AF2122/97           AGGRGGLLIGDGGAG-------GAGGVGGTGGSG---------APGGGG-
Rv0872c|M.tuberculosis_H37Rv        AGGRGGLLIGDGGAG-------GAGGVGGTGGSG---------APGGGGG
MMAR_2490|M.marinum_M               QGGNGGLLFGNGGTG-------GVGGTGGMGGAG---------AAGGTG-
TH_3810|M.thermoresistible__bu      HGGRGGFL-GIGGSG-------GWGGHGGNGGD-----------TDADG-
Mflv_5091|M.gilvum_PYR-GCK          KGGTGGTG-GAGGTG----GDGGTGGTGGTGGTG---------GTGGTG-
Mvan_1264|M.vanbaalenii_PYR-1       KGGTGGTG-GDGGTG----GTGGTGGTGGTGGTG---------GTGGTG-
MSMEG_0868|M.smegmatis_MC2_155      RGGDGALG-GNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNG-
MUL_0572|M.ulcerans_Agy99           KGGTGVVG-GNGGSG-------GAAYNYGTGNAT---------GAGGSS-
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      AAVGGVLNTGVSGAIG------GSSHVGGAINES----------LGGSGS
MAV_4827|M.avium_104                QLLAPPRLSVPQPVQP------PVRVPQPPSPPQ----------VGGTVP
                                                                                      

Mb0896c|M.bovis_AF2122/97           AGGDGGAAN-------------TDSAGSSR--------KAFGGDGG----
Rv0872c|M.tuberculosis_H37Rv        AGGDGGAAN-------------TDSAGSSR--------KAFGGDGG----
MMAR_2490|M.marinum_M               --GDGGNAG-------------FAIGGSDG--------TATGQQGG----
TH_3810|M.thermoresistible__bu      --GNGGDG---------------GNGGSAG--------------------
Mflv_5091|M.gilvum_PYR-GCK          --GTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG----
Mvan_1264|M.vanbaalenii_PYR-1       --GTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG----
MSMEG_0868|M.smegmatis_MC2_155      --GNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALI
MUL_0572|M.ulcerans_Agy99           --GSGGAASVPN--SASTATATSGSGGAGG----DGTDGGNGGSGG----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VGGSTAVGG-------------GAHTGVGG--------GVSTGVGVG---
MAV_4827|M.avium_104                QSPPQHQTP-------------PGEGTPPK--------------------
                                                                                      

Mb0896c|M.bovis_AF2122/97           -------------VGGDGASALGTGGEGGIG-------------------
Rv0872c|M.tuberculosis_H37Rv        -------------VGGDGASALGTGGEGGIG-------------------
MMAR_2490|M.marinum_M               -------------DGGYGADSTAVGGTGGAG-------------------
TH_3810|M.thermoresistible__bu      -------------RGGTGGLRGVFGINGGNG-------------------
Mflv_5091|M.gilvum_PYR-GCK          -------------TGGTGGQGG-LGGGGGTG-------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------TGGTGGQGG-LGGVGGTG-------------------
MSMEG_0868|M.smegmatis_MC2_155      RATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASG
MUL_0572|M.ulcerans_Agy99           ----------FAFTFGTGNIIAGVGGGGGTG-------------------
MLBr_01183|M.leprae_Br4923          -------------------MPLFLNAEPQAL-------------------
MAB_4284c|M.abscessus_ATCC_199      -------------SHVGGGISESLGGSGSVG-------------------
MAV_4827|M.avium_104                -------------PDGPGNYGGGHVPTPGAG-------------------
                                                                                      

Mb0896c|M.bovis_AF2122/97           ----GQGGNGGAGGLLIGNGGAGGVGGTA--------GAGGTGGSGGAGG
Rv0872c|M.tuberculosis_H37Rv        ----GQGGNGGAGGLLIGNGGAGGVGGTA--------GAGGTGGSGGAGG
MMAR_2490|M.marinum_M               ----GTGGNGGNGGWLIGSGGAGGVSGTG--------GVGGTGGAGGAGG
TH_3810|M.thermoresistible__bu      -----RAGLGGRGX-XXXGGGVGAAVRSG---------------NGVFSG
Mflv_5091|M.gilvum_PYR-GCK          ----GQGGTGGTGG-QGGTGGTGGTGGTG--------GTGGAGGDGGLGG
Mvan_1264|M.vanbaalenii_PYR-1       ----GTGGTGGTGG-QGGTGGTGGTGGTG--------GTGGAGGDGGLGG
MSMEG_0868|M.smegmatis_MC2_155      TATDGHGGSGINGG-HGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGG
MUL_0572|M.ulcerans_Agy99           --STGVGGIGGSGGGADINNGAFTVVPQG--------GAGGHGGDGATDG
MLBr_01183|M.leprae_Br4923          -----------TAAANTLEGLSAATVASN------------AAAAQLTTE
MAB_4284c|M.abscessus_ATCC_199      -------GSTAVGGGAHTGVGGGVSTGVG---------VGSHVGGGISES
MAV_4827|M.avium_104                -------GSGGSGGGHVPTPGAGGSGGSG----------GGHVPTPGTGG
                                                .                                     

Mb0896c|M.bovis_AF2122/97           AGGAGGGGTNSGPGAAFG-----GNGNTGGN-------------------
Rv0872c|M.tuberculosis_H37Rv        AGGAGGGGTNSGPGAAFG-----GNGNTGGN-------------------
MMAR_2490|M.marinum_M               IGGIGGNTSSSSTASVAGEGGHGGDGGDGGD-------------------
TH_3810|M.thermoresistible__bu      GGGTPSAGFGVPTTIQFPAGSCTSRAVSREG-------------------
Mflv_5091|M.gilvum_PYR-GCK          LGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----G
Mvan_1264|M.vanbaalenii_PYR-1       LGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----G
MSMEG_0868|M.smegmatis_MC2_155      LGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQ
MUL_0572|M.ulcerans_Agy99           --GAGGAGGFTEIDSSASVIAATGGAGGDGG---SGGTGRGGTGGG---G
MLBr_01183|M.leprae_Br4923          IAPPAADDVSILLAHFFSGHGRQYQAHASQG-------------------
MAB_4284c|M.abscessus_ATCC_199      LGGSGSVGGSTAVGGGAHTGVGGGVNTGVGVG------------------
MAV_4827|M.avium_104                PGGTGGSGGGHVPTPGAGTPGGSGGG------------------------
                                         .                                            

Mb0896c|M.bovis_AF2122/97           ------GGNGGAPGALGG---------------------------KGGSG
Rv0872c|M.tuberculosis_H37Rv        ------GGNGGAPGALGG---------------------------KGGSG
MMAR_2490|M.marinum_M               ------GGNGGAAGAVAG---------------------------AGGRG
TH_3810|M.thermoresistible__bu      -----IMPSSRAASARAG---------------------------AACAS
Mflv_5091|M.gilvum_PYR-GCK          SGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAA
Mvan_1264|M.vanbaalenii_PYR-1       SGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGAS
MSMEG_0868|M.smegmatis_MC2_155      SGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNT
MUL_0572|M.ulcerans_Agy99           TGGGGTGGGGGVGINNGSGEAIGGAPGAGGTG------AVGGDGGQGGAA
MLBr_01183|M.leprae_Br4923          --------ATNHQDLIQS--------------------------LLTSSS
MAB_4284c|M.abscessus_ATCC_199      -----SHVGGGISESLGG---------------------------SGSVG
MAV_4827|M.avium_104                -----HLPFPGAGSTPGG-----------------------------SGG
                                                     .                                

Mb0896c|M.bovis_AF2122/97           GLIGRAGSDGGVGAGGAGG-------------------------------
Rv0872c|M.tuberculosis_H37Rv        GLIGRAGSDGGVGAGGAGG-------------------------------
MMAR_2490|M.marinum_M               GLIGAAGGTGSIGAGGAAG-------------------------------
TH_3810|M.thermoresistible__bu      STSRSRRSFCCSRA------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGS
Mvan_1264|M.vanbaalenii_PYR-1       GAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGS
MSMEG_0868|M.smegmatis_MC2_155      ATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGG
MUL_0572|M.ulcerans_Agy99           YSYGTGDATGSAGAAGTAG-----------TTGVGGTGGAGGAAYTLNGA
MLBr_01183|M.leprae_Br4923          AYAGTETANHDSL-------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GSTAVGGGAHTSAINDALG-------------------------------
MAV_4827|M.avium_104                GHLPTPGAGTPGGGLGGFG-------------------------------
                                           .                                          

Mb0896c|M.bovis_AF2122/97           --------------------------------------------AGGAGG
Rv0872c|M.tuberculosis_H37Rv        --------------------------------------------AGGAGG
MMAR_2490|M.marinum_M               --------------------------------------------AGGAGG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          QGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG
Mvan_1264|M.vanbaalenii_PYR-1       QGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG
MSMEG_0868|M.smegmatis_MC2_155      KGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGG
MUL_0572|M.ulcerans_Agy99           STAT-------ATGGIG----------GNGGDGGTANGS--NGGNGGAGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------------------------------------------GSGSVGG
MAV_4827|M.avium_104                ---------------------------------------------GGHAP
                                                                                      

Mb0896c|M.bovis_AF2122/97           ----------------------------------------TGGEGGTGG-
Rv0872c|M.tuberculosis_H37Rv        ----------------------------------------TGGEGGTGG-
MMAR_2490|M.marinum_M               ----------------------------------------AGGAGGAGGT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          -----------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGG-
Mvan_1264|M.vanbaalenii_PYR-1       -----------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGG-
MSMEG_0868|M.smegmatis_MC2_155      NTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGG-
MUL_0572|M.ulcerans_Agy99           -------YASTTGTGTASVGNGGRGGDGTAT-------VATGGTGGVGGN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------STAVGGGAHTSAINESMNSSINASHSSSMNESFGS
MAV_4827|M.avium_104                ---------------------------------------APGGGLGGGGG
                                                                                      

Mb0896c|M.bovis_AF2122/97           -DGKTTDGNPGMGGSPGSAGQPGQPG----------
Rv0872c|M.tuberculosis_H37Rv        -DGKTTDGNPGMGGSPGSAGQPG-------------
MMAR_2490|M.marinum_M               AQGSGASGGTGANGHTGLDGAPGQPG----------
TH_3810|M.thermoresistible__bu      ------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          -SGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1       -SGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155      -TTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP
MUL_0572|M.ulcerans_Agy99           AHAPAGSPVPGVGGKGGNPGPGGKPGPNGADGIVV-
MLBr_01183|M.leprae_Br4923          ------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH
MAV_4827|M.avium_104                HAPAPGGGLGGFGGGHSGGGLGGLGGGHK-------