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SYLIAAPELMQSAAADLAGIESALSAANVSAAVPTTQILAAGADEVSAAIAALFGAHAQAYQALGSHVTA FHQEFVQALNSGAASYANAEAASIAPLQALYDLVNAPTQALLGRPLIGNGANGAPGTGQNGGDGGLLFGN GGAGGSGADGQNGGAGGNAGFFGSGGAGGAGGNTDLFGNNGAVGGAGGAGGWLIGSGGAGGTGGIGAFNG GAGGAGGSAWLFGTGGVGGTGGIGTLGVGGAGGAGGGSGVLSFADGGAGGFGGSGANAGGVGGSGGAAGI FGTGGAGGTGGAGGTNGLEIGQVSVGGAGGDGGRGGWLLGIGGSGGFGGFGQGPSGGIGGDGGDAGLFGV GGIGGTGGTGFSGVGGNAGAGGDGGLLWGSGGAGARGGQGGAGAGGIGGAGGGGGLFGGDGGAGGVGGTG AGGPGGAGGVGGDAGLFGVGGAGGVGGTGVGFPTDPGLSFGGQGGAGGRGGLLIGLGGNGGTGGFSGPLS AGAGGGDGGAGGGVGLIGFGGAGGFGGASGFGTGGAGGVGGAGGALFGVGGVGGNGAWGAGGIGGDGGVG GAGSALGFGLGGAGGAGGASGLGDGGAGGTGGAGGLLGGNGGGGGAGGAGAVGFLDNTADGAGGAGGAGG SGGLLFGDGGVGGAGGAGGISTSSSVNNGGAGGAGGNAGGLFGSGGAGGIGGAVGTGGTVAGAGGDGGGA GWVGNAGNGGAGGDGWTNGNGGDGGDGGDAVLVGNGGNGGNGGTGLVAGSTGTGGTSGFLLGLDGFNASG STSPLHILQQQTLNAINAPFDALTGRPLIGNGTPGAAGSGADGTAGGWLLGNGGAGGSGADGQNGGAGGN AGFFGSGGAGGAGGNTDLFGNNGAVGGAGGAGGWLIGSGGAGGTGGIGAFNGGAGGAGGSAWLFGTGGVG GTGGIGTLGVGGAGGAGGGSGVLSFADGGAGGFGGSGANAGGVGGSGGAAGIFGTGGAGGTGGAGGTNGL EIGQVSVGGAGGDGGRGGWLLGIGGSGGFGGFGQGPSGGIGGDGGDAGLFGVGGIGGTGGTGFSGVGGNA GAGGDGGLLWGSGGAGARGGQGGAGAGGIGGAGGGGGLFGGDGGAGGVGGTGAGGPGGAGGVGGDAGLFG VGGAGGVGGTGVGFPTDPGLSFGGQGGAGGRGGLLIGLGGNGGTGGFSGPLSAGAGGGDGGAGGGVGLIG FGGAGGFGGASGFGTGGAGGVGGAGGALFGVGGVGGNGAWGAGGIGGDGGVGGAGSALGFGLGGAGGAGG ASGLGDGGAGGTGGAGGLLGGNGGGGGAGGAGAVGFLDNTADGAGGAGGAGGSGGLLFGDGGVGGAGGAG GISTSSSVNNGGAGGAGGNAGGLFGSGGAGGIGGAVGTGGTVAGAGGDGGGAGWVGNAGNGGAGGDGWTN GNGGDGGDGGDVGLFGAGGNGGNGGTGVTAGTGGTGGSGGLLGPDGINGS*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_5044 | - | - | 100% (1451) | PE-PGRS family protein |
M. marinum M | MMAR_5294 | - | 0.0 | 47.69% (1707) | PE-PGRS family protein |
M. marinum M | MMAR_4316 | - | 0.0 | 48.01% (1706) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3541 | PE_PGRS55 | 0.0 | 47.20% (1748) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-170 | 47.52% (827) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 0.0 | 47.34% (1749) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 6e-12 | 36.96% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 5e-50 | 35.53% (425) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 1e-24 | 45.11% (184) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-146 | 39.00% (1100) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 3e-40 | 40.34% (295) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 47.43% (1166) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-168 | 47.87% (823) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_5044|M.marinum_M -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mb3541|M.bovis_AF2122/97 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_5044|M.marinum_M -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -----------MSFVLIAPEFVTAAAGDLTNLGSSISAANASAASATTQV MUL_4367|M.ulcerans_Agy99 -----------MSFVSVGPGLLEAAARDLAGLGAGLREANLAAAGATVGV Mb3541|M.bovis_AF2122/97 -----------MSFVLISPEVVSAAAGDLANVGSTISAANKAAAAATTQV Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------MMFLAPPGGPGPISAAIQL MMAR_5044|M.marinum_M -----------MSYLIAAPELMQSAAADLAGIESALSAANVSAAVPTTQI MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 ----------MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTEI MAB_4284c|M.abscessus_ATCC_199 -----------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAA MAV_4827|M.avium_104 -----------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGA Rv3508|M.tuberculosis_H37Rv LAAGADEVSARIAALFGGFGLEYQAISAQVAAYHQRFVQALSTGAGAYAS MUL_4367|M.ulcerans_Agy99 LPAAGDEVSAAIAELFGGFGREYQAMGARVALLHDDFVRALTAGGSAYGQ Mb3541|M.bovis_AF2122/97 LAAGADEVSARIAALFGMYGLEYQAISAQVAAYHQQFVQTLRTGAASYML Mflv_5091|M.gilvum_PYR-GCK ------------MVTFGGGA------TPTPTSLGAAAVDLSGTSCG---- Mvan_1264|M.vanbaalenii_PYR-1 TSTGSEATEPWYVVSFGGSG------APTPNNLAASLVDLSGTSCG---- MMAR_5044|M.marinum_M LAAGADEVSAAIAALFGAHAQAYQALGSHVTAFHQEFVQALNSGAASYAN MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 APPAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSAY-- MAB_4284c|M.abscessus_ATCC_199 QVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPD---- MAV_4827|M.avium_104 DDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALR--- Rv3508|M.tuberculosis_H37Rv AEAA---------------AAEQIVLGVINAPTQALLGRPLIGDGAN-AT MUL_4367|M.ulcerans_Agy99 AEALNMWP---------LQELEQQALGVVNAPSMALFGRPSIGNGVDGVA Mb3541|M.bovis_AF2122/97 AEATN---------------VEQNLLNLINAPTQTLLGRPLIGDGAN-AT Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------LICNGQD--- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------LICNGQD--- MMAR_5044|M.marinum_M AEAAS-------------IAPLQALYDLVNAPTQALLGRPLIGNGANGAP MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGIN-GT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------AGTE--- MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------GPSILS MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv TPGGAGGAGGLLFGNGGAGA-AGAPGQAGGPGGPAGLWGNGGPGGAGGSG MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGG-- Mb3541|M.bovis_AF2122/97 TPGGAGGDGGLLFGSGGNGA-PGAPGQAGGAGGSAGLLGNGGSGGAGGTG Mflv_5091|M.gilvum_PYR-GCK ---GTGQNGGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNG-- Mvan_1264|M.vanbaalenii_PYR-1 ---GTGQNGGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNG-- MMAR_5044|M.marinum_M GTGQNGGDGGLLFGNGGAGG-SGADGQNGGAGGNAGFFGSGGAGGAGG-- MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFGNGGNGGVGW-- TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 ----TANHDSL--------------------------------------- MAB_4284c|M.abscessus_ATCC_199 PSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRG------ MAV_4827|M.avium_104 ----DALAARRIDNVMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPD-- Rv3508|M.tuberculosis_H37Rv GGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAGGVGG MUL_4367|M.ulcerans_Agy99 ---------------VGAAG----MTGGSGGAGGGGGWLWGAGGSGGAAG Mb3541|M.bovis_AF2122/97 -APGGNGGNAGWLYGRGGVGGAGGIGGGTGGAGG-HAWLFGHGGTGGIGG Mflv_5091|M.gilvum_PYR-GCK ------------------------LGGGNGGNGGNAGAFALFGN------ Mvan_1264|M.vanbaalenii_PYR-1 ------------------------LGSGDGGNGGDAGLFSLFGR------ MMAR_5044|M.marinum_M ------------------NTDLFGNNGAVGGAGGAGGWLIGSGGAGGTGG MSMEG_0868|M.smegmatis_MC2_155 -------------------------AGLDGGNGGSGGLLMGIGGAGGAGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv AGGGTGGAGGRAELLFGAGGAGGAGTDGGPGATGGTGGHGGVGGDGGWLA MUL_4367|M.ulcerans_Agy99 AGG--------------------------------------SGGSGGWLW Mb3541|M.bovis_AF2122/97 GPGGNGG--------------WLLGNGGHGGAGGIGGGSGGAGGNGGWLL Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_5044|M.marinum_M IGAFNGG--------------------------------AGGAGGSAWLF MSMEG_0868|M.smegmatis_MC2_155 VG------------------------------------------------ TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv PGGAGGAGGQGGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGG MUL_4367|M.ulcerans_Agy99 G--------------------------NAGQTAGAG-------------- Mb3541|M.bovis_AF2122/97 GNGGIGGAG-GTGGGAGGTGGNAAWLLGGGGTGGAGGIGGGNGGHGGNGG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_5044|M.marinum_M G------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------------------AD TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv QGGLGGAGGQGGTGGAGGDGVLGGVGGTGGKGGVGGVAGLGGAGGAAGQL MUL_4367|M.ulcerans_Agy99 ---VGGAGGAGGAGDAGDQGVSG--------------------------- Mb3541|M.bovis_AF2122/97 --WLLGNGGNGGLGGDGDGGTGGGHGGNGGNPGWLLGTAGGGGNGGAGST Mflv_5091|M.gilvum_PYR-GCK ----GGNGGNGGVGVVGATGAVG--------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ----GGNGGNGGVGIAGATGAVG--------------------------- MMAR_5044|M.marinum_M ---TGGVGGTGGIGTLGVGGAGG--------------------------- MSMEG_0868|M.smegmatis_MC2_155 GTSAHVDGGTGGTGGTGG-------------------------------- TH_3810|M.thermoresistible__bu -----VD----GDGGSGG-------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv FSAGGAAGAVGVGGTGGQGGAGGAGAAGADAPASTGLTGGTGFAGG-AGG MUL_4367|M.ulcerans_Agy99 --------------------------------VAPGEAGAVGFAGG-AGG Mb3541|M.bovis_AF2122/97 GTAGGGSGGTG-GDGGTGGRGGLLMGAGAGGHGGTGGAGGAGVDGGGAGG Mflv_5091|M.gilvum_PYR-GCK ---------------------------------APGVAGATGATGVTSGV Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------APGVAGATGATGVTSNV MMAR_5044|M.marinum_M ---------------------------------AGGGSGVLSFADGGAGG MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------GTGGTGGIGGTGGGLFG TH_3810|M.thermoresistible__bu ---------------------------------RTG-----------LFS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------PLLDLSFGD MAV_4827|M.avium_104 ----------------------------------TATLAVVETSDGSIPD Rv3508|M.tuberculosis_H37Rv VGGQGGNAIAGG----INGSGGAGGTGGQGGA--GGMGGSGADNASG-IG MUL_4367|M.ulcerans_Agy99 AGGAGGNGVGGG----VNGAGGAGGAGGVGGG--GGAGASGVG-----AG Mb3541|M.bovis_AF2122/97 AGGAGGNGGAGGQAALLFGRGGTGGAGGYGGD--GGGGGDGFDGTMAGLG Mflv_5091|M.gilvum_PYR-GCK VGGNGEDAVGYG------ATGAAGAAGAAGAA--GAAG------------ Mvan_1264|M.vanbaalenii_PYR-1 TGGNGADAVGYG------ATGAAGAAGAAGAA--GKAG------------ MMAR_5044|M.marinum_M FGGSGANAGGVGGSGGAAGIFGTGGAGGTGGA--GGTNGLEIG--QVSVG MSMEG_0868|M.smegmatis_MC2_155 LLGHSGSTGAAG----AAGNGGDGGNGGFGYVLIAGPNVTVGSETRGGTG TH_3810|M.thermoresistible__bu KLSR----------------GGDGGDGGLG-------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LQFGNRDTTAIG--------DGAVAVGGS--------------------- MAV_4827|M.avium_104 VYKQQIRAESYG--------DAAGQLSAMVAG------------------ Rv3508|M.tuberculosis_H37Rv ADGGAGGTG----GNAGAGGAG--GAAGTGGTGGVVGAAGKAGIGGTGGQ MUL_4367|M.ulcerans_Agy99 VAGGDGGTG----GAGGAAGVG--GAAGTGGTG------GAAGVAGTGGD Mb3541|M.bovis_AF2122/97 GTGGSGGTG----GDGGAPGNG--GAGGAGQLLSHSGVAGASGKGGAGGT Mflv_5091|M.gilvum_PYR-GCK -AVGSAGAA----GEAGETGTW--GNAGL--------------PGKAGDA Mvan_1264|M.vanbaalenii_PYR-1 -AVGSAGTA----GSAGAPGVW--GNAGL--------------PGAAGAA MMAR_5044|M.marinum_M GAGGDGGRGGWLLGIGGSGGFGGFGQGPSGGIGGDGGDAGLFGVGGIGGT MSMEG_0868|M.smegmatis_MC2_155 GAGGTGGQSTAAGPGKGGGGGG--GGGGAILIGANGGTVDGHAIGGNGGN TH_3810|M.thermoresistible__bu ----------------GNGGHG--GGTGIISLLS---------LAGNGGN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------NSGPIASG---------------------QGSTAVN MAV_4827|M.avium_104 ------------LEKLESLPGG-------------------LLLVGSGVD Rv3508|M.tuberculosis_H37Rv GGAGGAGSAGTDATA----TGATGGTGFSGGAGGAGGAGGNTGVG-GTNG MUL_4367|M.ulcerans_Agy99 GGDGGAGGAGSDASL----AGQAG---FAGGSGGAGGVGGSAGAG-GVNG Mb3541|M.bovis_AF2122/97 GGNGGAGSAGADAPAG---SGAMGSTGFAGGAGGDGGNGGGSGASQGNGG Mflv_5091|M.gilvum_PYR-GCK GGAGAVGAAG-----------------AAGTVGTAGATGG--------TG Mvan_1264|M.vanbaalenii_PYR-1 GGAGAIGTAG-----------------VAGAAGTAGATGG--------TG MMAR_5044|M.marinum_M GGTGFSGVGGNAGAG-----GDGGLLWGSGGAGARGGQGGAGAGGIGGAG MSMEG_0868|M.smegmatis_MC2_155 GGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHSTGT-GIGG TH_3810|M.thermoresistible__bu GGNGYRTTDNN---------------------ALDGGHGGN-------GG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GDVRDSNIIN----------------------ADHGSNVGVDQSQTRVGG MAV_4827|M.avium_104 VAPLKQVLQTTT---------------FLDVSVAEEPETALARGAALAAA Rv3508|M.tuberculosis_H37Rv SGG--QGGTGGAGGAGGAGGVGAD--NPTGIGGTGGTGGKGGAGGAGGQG MUL_4367|M.ulcerans_Agy99 SGG--DGGAGAAGGAGGASAT---------VAGSGGVGGDGGAGGAAG-- Mb3541|M.bovis_AF2122/97 NGG--NGGTGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGNAGAGGTG Mflv_5091|M.gilvum_PYR-GCK TGA--NGGAGGVGGVG----------------GTGAAGAAGGAG------ Mvan_1264|M.vanbaalenii_PYR-1 VGG--NGGAGQAGGIG----------------GTGAAGAAGQAG------ MMAR_5044|M.marinum_M GGGGLFGGDGGAGGVGGTG-----------AGGPGGAGGVGGDAGLFG-- MSMEG_0868|M.smegmatis_MC2_155 NGG--IGSVYAYGNNGAVSGT-----------ATGGRGGDGIDGGTGGAG TH_3810|M.thermoresistible__bu NVG--FFSLFNLG-------------------GAGGWGGSGVDG------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 DYTN--------------------------VSGHGSADIDKS-------- MAV_4827|M.avium_104 NAPLFASSTAALAYAQDP--------------GTGAVDQYSLPDYLYVP- Rv3508|M.tuberculosis_H37Rv GSSGAGGTNGSGGAGGTGGQGGAGGAGGAGADNPTGIGGAGGTGGTGGAA MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mb3541|M.bovis_AF2122/97 FTQGADGNAGNGGDGGVGGNGGNGADN-------TTTAAAGTTGGAGGAG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_5044|M.marinum_M -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GM---------------------------------------------GEI TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GAGGAGGAIGTGGTGGAVGSVGNAGIGGTGGTG----GVGGAGGAGAA-- MUL_4367|M.ulcerans_Agy99 ------------------GGVGAASLGGDGGHA----GAGGAGGEGLS-- Mb3541|M.bovis_AF2122/97 GAGGTGGTGGAAGTG-TGGQQGNGGNGGNGGTG----GKGGTGGAGMNSL Mflv_5091|M.gilvum_PYR-GCK ------------------------GLGETGTTG----GAGGVGG------ Mvan_1264|M.vanbaalenii_PYR-1 ------------------------TAGETGVTG----GVGGIGG------ MMAR_5044|M.marinum_M -VGGAGGVGGTGVGFPTDPGLSFGGQGGAGGRGGLLIGLGGNGGTGGFS- MSMEG_0868|M.smegmatis_MC2_155 YSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGT TH_3810|M.thermoresistible__bu ----------------------VDVVGGN--------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------VTVVDDHSQRN----------------- MAV_4827|M.avium_104 ----------------------VDPEPGDD-------------------- Rv3508|M.tuberculosis_H37Rv AAAGSSATGGAGFAGGAGGEGGAGGNSGVGGTNGSGGAGGAGGKGGTGGA MUL_4367|M.ulcerans_Agy99 GGFNTGAAGGIGGAGGAGGTGGDSG--GVGGVNGDGGAGGGGGRGGDGGS Mb3541|M.bovis_AF2122/97 DPLLAAQDGGQGGTGGTGGNAGAGGTGFTQGADGNAGNGGDGGVGGNGGN Mflv_5091|M.gilvum_PYR-GCK -------QGTAGGTGGVGGIGGAGSTGAVGGVGGKGIQGGQGLQGGKGG- Mvan_1264|M.vanbaalenii_PYR-1 -------QGTEGGTGGVGGVGGVGATGGAGGVGGKGIQGGQGLQGGQGG- MMAR_5044|M.marinum_M GPLSAGAGGGDGGAGGGVGLIGFGGAGGFGGASGFG-TGGAGGVGGAGGA MSMEG_0868|M.smegmatis_MC2_155 AKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGA TH_3810|M.thermoresistible__bu ---------PDGGTPG---------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------TTNINDSFNTDRSTNIGSGNTTNTEIGSHNQANIGTSTSAGG- MAV_4827|M.avium_104 -------ELAYSAVGEEDAESPTVVIEKLFLPEDSEPRRRPVLLVGSGLA Rv3508|M.tuberculosis_H37Rv GGSGADNPTGAGFAGGAGGTGGAAGAGGAGGATGTGGTGGVVGATGSAGI MUL_4367|M.ulcerans_Agy99 STS----TSGVGGAGGAGGNGGNAGFGVSAGGTG-----------GSAGD Mb3541|M.bovis_AF2122/97 GADN-TTTAAAGTTGGAGGAGGAGGTGGTGGAAGTG-TGGQQGNGGNGGN Mflv_5091|M.gilvum_PYR-GCK -------------DGGAGGKGGDADSMGSAGATG--------------GK Mvan_1264|M.vanbaalenii_PYR-1 -------------DGGTGGTGGDATSMGEAGATG--------------GK MMAR_5044|M.marinum_M LFG--VGGVGGNGAWGAGGIGGDGGVGGAGSALG----------FGLGGA MSMEG_0868|M.smegmatis_MC2_155 VGGN---GGFTNIAAIHGSITDSSATSGHGGAAQ-------------GGN TH_3810|M.thermoresistible__bu ---------------AHG-------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------SAAVGGNAGLAGNAGLAG---------------- MAV_4827|M.avium_104 VVG------------ISAVLALEIALAIGIRTTG---------------- Rv3508|M.tuberculosis_H37Rv GGAGGRGGDGGDGASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGAGGAG MUL_4367|M.ulcerans_Agy99 GGAGG---------------------------------GAGGVDGVGGAS Mb3541|M.bovis_AF2122/97 GGTGGKGGTGGAGMNSLDPLLAAQDGGQGGTGGTGGNAGAGGTGFTQGAD Mflv_5091|M.gilvum_PYR-GCK GGNG----------------------------------GNGGRGGLFGKG Mvan_1264|M.vanbaalenii_PYR-1 GGNG----------------------------------GNGGRGSLFGRG MMAR_5044|M.marinum_M GGAGGASG-----------------------------LGDGGAGGTGGAG MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGW-------------------------VQAYDPNGPAGTTIDKG TH_3810|M.thermoresistible__bu ----------------------------------ESHTP----GVYTDRQ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------------------------NAGLAGNAG MAV_4827|M.avium_104 ---------------------------------------TVALQPTPNQH Rv3508|M.tuberculosis_H37Rv ----GNGGDGGDGATGA-----------AGLGDNGGVGGDGGAGGAAGNG MUL_4367|M.ulcerans_Agy99 ----GNGGAAGAGGAGG-----------SGIG----AGIDGGAGGAGGTG Mb3541|M.bovis_AF2122/97 ----GNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGGTG Mflv_5091|M.gilvum_PYR-GCK ----GNAGNGADGGTGG----------------------AGGAGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 ----GNAGNGGNGGTGG----------------------NGGNGGTGGTG MMAR_5044|M.marinum_M GLLGGNGGGGGAGGAGAVG------------FLDNTADGAGGAGGAGGSG MSMEG_0868|M.smegmatis_MC2_155 KAAGGNGGDGGFNGTGG------------------------ATGGRGGDG TH_3810|M.thermoresistible__bu -------GEDGEDGTGT------------------------GIGGRGGNG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----LAGNAGLAGNAG----------------------LAGNAGLAGNA MAV_4827|M.avium_104 LIVPTEQAPAPPPVQASAP--------------------QPKISVPEPVA Rv3508|M.tuberculosis_H37Rv GNAGVGLTAKAGDGGAAGNGGNGGAGGAGGAGDNNFNGGQGGA--GGQGG MUL_4367|M.ulcerans_Agy99 GAAGF-----PGGGGTTGAWGTGGAGGAGGAG------------------ Mb3541|M.bovis_AF2122/97 GAAGTGTGGQQGNGGNGGNGGTGGKGGTGGDGALAGSSGGAGGKGGNGGD Mflv_5091|M.gilvum_PYR-GCK G-----------------AGGTGGTGGTGGIG------------------ Mvan_1264|M.vanbaalenii_PYR-1 G-----------------NGGTGGTGGTGGIG------------------ MMAR_5044|M.marinum_M G-------------LLFGDGGVGGAGGAGGISTSSSVNNGGAG------- MSMEG_0868|M.smegmatis_MC2_155 AGASV--------------WKANGQHSTGQTDTGGNGGRGGDG------- TH_3810|M.thermoresistible__bu G-------------------SSSGTHPMAE-------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 G-----------------LAGNAGLAGNAG-------------------- MAV_4827|M.avium_104 AP---------------KPLSPPVAAPLPAAP------------------ Rv3508|M.tuberculosis_H37Rv QGGLGGASTTSINANGGAGGNGGTGGKGGAGGAGTLGVGGSGGTGGDGGD MUL_4367|M.ulcerans_Agy99 ------------------------------------GAGDHGGVGVNPGD Mb3541|M.bovis_AF2122/97 AGKAGTGSAPGTAGTGGDGGKGGNGGIGAAGTTGPVGTGASGGTGGSGGA Mflv_5091|M.gilvum_PYR-GCK ------------------------------------GAGSTGGTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------GAGSTGGTGGTGGT MMAR_5044|M.marinum_M -----------------------------GAGGNAGGLFGSGGAGGIGGA MSMEG_0868|M.smegmatis_MC2_155 ------------------------------------GTFVNAGANGNGGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------LAGNAGLAGNAGL MAV_4827|M.avium_104 -------------------------------------PPAAPPLPEAPPI Rv3508|M.tuberculosis_H37Rv AGSGGGGGFG--GAAGKAGGGGNGGRGGDGGDGASGLGLGLSGFDGGQGG MUL_4367|M.ulcerans_Agy99 SGTAG--------------------------------------WAGGAGG Mb3541|M.bovis_AF2122/97 GGTGGDGGAANGGTAGAGGAGGNGGKGGDGGAGVTSSTAGNSGGAGGSGG Mflv_5091|M.gilvum_PYR-GCK GGTGG---------------------------------------TGGTGG Mvan_1264|M.vanbaalenii_PYR-1 GGTGG---------------------------------------TGGTGG MMAR_5044|M.marinum_M VGTGG-----------------------------------TVAGAGGDGG MSMEG_0868|M.smegmatis_MC2_155 GGAGG-----------------------------------VSEGEGGTGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AGNAG---------------------------------------LAGNAG MAV_4827|M.avium_104 PAAPP---------------------------------------VVPVPV Rv3508|M.tuberculosis_H37Rv QGGAGGSAGAGGINGAGGAGGNG-GDGGDGATGAAGLGDNGGVG--GDGG MUL_4367|M.ulcerans_Agy99 AGGAGGSAAFNGVNGAGGAGGNG-GAGGGGGAGASGIG-AGVAG--GDGG Mb3541|M.bovis_AF2122/97 KGGDAGAGGAGATPGANGIAGNG-GDGGDGAAGAVGISGATGAGDGGHGG Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGGTGGKGGTGGTGGAG-GTGGDG----------------GTGG Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGTGGTGGKGGTGGTGGDG-GTGGTG----------------GTGG MMAR_5044|M.marinum_M GAGWVGNAGNGGAGGDGWTNGNG-GDGGDG----------GDAVLVGNGG MSMEG_0868|M.smegmatis_MC2_155 HGGDGGRGGDGALGGNGGTGGVGLGNGGKG----------------GNGG TH_3810|M.thermoresistible__bu -DGEHVKALDGRPGLDG-------GNGSHG----------------GNGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAGLAGNAGLAGNAG--------------LAGNAG MAV_4827|M.avium_104 VVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVPQPPSPPQ Rv3508|M.tuberculosis_H37Rv AGGAAGNGGNAGVGLT----AKAGDGGAAGNGGNGGAGGAGGAGDNNFNG MUL_4367|M.ulcerans_Agy99 TGGTGG---------------AAGTGGAAGTGGTGGAAGAAGS------- Mb3541|M.bovis_AF2122/97 TGGAGGNGGTGGAGGSGIDGVGGGTGGTGGNGGNGAIGGAGGDAGGSGNS Mflv_5091|M.gilvum_PYR-GCK TGGTGG------------------TGGTGGTGGTGGAG------------ Mvan_1264|M.vanbaalenii_PYR-1 TGGTGG------------------TGGTGGTGGTGGAG------------ MMAR_5044|M.marinum_M NGGNGG---------------TGLVAGSTGTGGTSGFLLGLDGFNASGST MSMEG_0868|M.smegmatis_MC2_155 NGGNGGTY------------VDPSHTGAGGNGGNGGAGRIRVN------- TH_3810|M.thermoresistible__bu HGGRGG------------------FLGIGGSGGWG--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGNAG------------------LAGNAAVAGNAAVAGN---------- MAV_4827|M.avium_104 VGGTVP----------------QSPPQHQTPPGEGTPP------------ Rv3508|M.tuberculosis_H37Rv GQGGAGGQGGQGGLGGASTTSINANGGAGGNGGTGGKGGAGGAGTLGVGG MUL_4367|M.ulcerans_Agy99 ----------------------------AGDGGAGGAGGAGDDGSAGVVS Mb3541|M.bovis_AF2122/97 GGNGGTGGKGGNAGAGGAAGSNGGTVGANGTGGDGGNGGAAGAATAGSNG Mflv_5091|M.gilvum_PYR-GCK ----------------------------DGTGGTGGTGGTGGQG------ Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------DGLGGTGGTGGTGGFG------ MMAR_5044|M.marinum_M SPLHILQQQTLNAINAPFDALTGRPLIGNGTPGAAGSGADGTAGGWLLGN MSMEG_0868|M.smegmatis_MC2_155 ----------------------NGTATGTATGGNGGNGGNGDADG----- TH_3810|M.thermoresistible__bu --------------------------------GHGGNGGDTDADG----- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------AAVAGNAAVGGVLNTG------ MAV_4827|M.avium_104 -----------------------------KPDGPGNYGGGHVPTP----- Rv3508|M.tuberculosis_H37Rv SGGTGGDGGDAGSGGGGGFG-----GAAGKAGGGGNGGVGGDGGEGASGL MUL_4367|M.ulcerans_Agy99 --------GDPG--------------TAGKAGGAG--------------- Mb3541|M.bovis_AF2122/97 GAGTGSAGGNGGTGGRGGSGGAGGDGIGGVGGGKGGNGADGEVGGAGGAG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_5044|M.marinum_M GGAGGSGADGQNGGAGGNAGFFGSGGAGGAGGNTDLFGNNGAVGGAGGAG MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GLGLSGFDGGQGGQGGAGGSAGAGGING-AGGAGGTGGAGGDGAPATLIG MUL_4367|M.ulcerans_Agy99 ------------GAGGVGGNGVAGGVNG-SGGAGGAG------------- Mb3541|M.bovis_AF2122/97 GSGPNTSPGGNGGQGGQGGSGGAGGAAG-AGGAGGGAN------------ Mflv_5091|M.gilvum_PYR-GCK ------------GQGGQGGTGGTGGQGG-LGGGGGTG------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------GQGGQGGTGGTGGQGG-LGGVGGTG------------- MMAR_5044|M.marinum_M G--------WLIGSGGAGGTGGIGAFNGGAGGAGGSAWLFG--------- MSMEG_0868|M.smegmatis_MC2_155 ------------HRGGKGGDGGEALIRATVIGSNASGT------------ TH_3810|M.thermoresistible__bu ------------GNGGDGGNGG---------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------VSGAIGGSSHVGGAIN---------------------- MAV_4827|M.avium_104 ------------GAGGSGGSGGGHVPTP---------------------- Rv3508|M.tuberculosis_H37Rv GPDGGDGGQGGIGGDGGNAGFGAGVPGDGGDGGNAGFGAGVPGDGGIGGT MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mb3541|M.bovis_AF2122/97 ----------------GTAGNGGQGGAGGTGGAGAASSATNGGSGGAGGT Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_5044|M.marinum_M -------------------------------------------------T MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv GGAGGAGGAGADGDPSIDGGQGGAGGHGGQGGKGG---------LNSTGL MUL_4367|M.ulcerans_Agy99 -GAGGTGGAGASGVP----------------------------------- Mb3541|M.bovis_AF2122/97 GGAGGTGGAGGDGVGGAGGGNGGHGGDAGDGGNGANGNNRSSGSFLAAGG Mflv_5091|M.gilvum_PYR-GCK -GQGGTGGTG---------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -GTGGTGGTG---------------------------------------- MMAR_5044|M.marinum_M GGVGGTGGIGTLGVGGAGGAGGGSG------------------------- MSMEG_0868|M.smegmatis_MC2_155 -ATGGDGGNG---------------------------------------- TH_3810|M.thermoresistible__bu --SAGRGGTG---------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---ESLGGSG---------------------------------------- MAV_4827|M.avium_104 -GAGGSGGSG---------------------------------------- Rv3508|M.tuberculosis_H37Rv ASAASGDGGNGGAGGAGGNGGDGDGFIGGSGGTGGTGGDAGVGGLANTGG MUL_4367|M.ulcerans_Agy99 ---ASVDGGDGGAGGAGG-----------AAGTGGSG------------G Mb3541|M.bovis_AF2122/97 TGGAAGDGGQGGQGGAGG-GAGGQGGAGGAGGTGGNGGN-ITGGTAGTAG Mflv_5091|M.gilvum_PYR-GCK --------GQGGTGGTGG-----------TGGTGGTG------------- Mvan_1264|M.vanbaalenii_PYR-1 --------GQGGTGGTGG-----------TGGTGGTG------------- MMAR_5044|M.marinum_M -VLSFADGGAGGFGGSGAN----------AGGVGGSG------------G MSMEG_0868|M.smegmatis_MC2_155 -------GTLGATNGTGGAATIVAYNVVQANPQASGT------------A TH_3810|M.thermoresistible__bu -------GLRGVF------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------SVGGSTAVGG-------------------------------- MAV_4827|M.avium_104 ----------GGHVPTPG-------------------------------- Rv3508|M.tuberculosis_H37Rv TAGNAGIGGAGGRGGDGGAGDSGALS--QDGNGFAGGQGGQGGVGGNAGA MUL_4367|M.ulcerans_Agy99 SAGNTGAGGAGGAGGAGGSAASTGVN--GDG------------------- Mb3541|M.bovis_AF2122/97 AAGNGGAAGKGGAGGQGGTGGGTGGQGGAGGDGGAGGTGGDRTVGGGTVP Mflv_5091|M.gilvum_PYR-GCK -----GAGGDGGLGGLGGFG------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 -----GAGGDGGLGGLGGFG------------------------------ MMAR_5044|M.marinum_M AAGIFGTGGAGGTGGAGGTNGLEIGQVSVGGAGGDGGRGGWLLGIGGSGG MSMEG_0868|M.smegmatis_MC2_155 TDGHGGSGINGGHGGNGGQGTIEANG--------------PSAVASGIGA TH_3810|M.thermoresistible__bu -------GINGGNGR----------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------GAHTGVGGGVSTG------------------------------ MAV_4827|M.avium_104 ------TGGPGGTGGSGG-------------------------------- Rv3508|M.tuberculosis_H37Rv GGINGAGGTGGTGGAGGDGQNGTTGVASEGGAGGQGGD--GGQGGIGGAG MUL_4367|M.ulcerans_Agy99 ----GAGGAGGVGGLGGDS-------AATAGGGGAGGD--GGKGGAGGAG Mb3541|M.bovis_AF2122/97 AGSGGQGGNAGGGGAGGQG-------GADGGSGGDGGD--AGTGGNGGNG Mflv_5091|M.gilvum_PYR-GCK ----GSGGTGGQGGLGGPG-------GSTGGAGGAGGQ--AGTAGKGGLF Mvan_1264|M.vanbaalenii_PYR-1 ----GVGGTGGQGGQGGPG-------GSTGGAGGAGGQ--AGVAGKGGLF MMAR_5044|M.marinum_M FGGFGQGPSGGIGGDGGDAG-----LFGVGGIGGTGGTGFSGVGGNAGAG MSMEG_0868|M.smegmatis_MC2_155 GGNGGDGIDGGLGGNGGDGV-----VNTTANAANPGSATGTATGGDGGKA TH_3810|M.thermoresistible__bu ---------AGLGGRGXX---------------------------XXGGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------VGVGSHVGGGIS-----ESLGGSGSVGGSTAVGGGAHTGVG MAV_4827|M.avium_104 ----GHVPTPGAGTPGGSGG------------------------------ Rv3508|M.tuberculosis_H37Rv GNAGFGAGVPGDGGIGGTG--GAGGAGGAG-ADGDPSIDGGQG------- MUL_4367|M.ulcerans_Agy99 VNGVGG----GDGGKGGTG--GAGGAGGAG-SDGIIPSNGGLG------- Mb3541|M.bovis_AF2122/97 GNRNSGNGTGGAGGNGGGG--ANGGAGGAGGSGGGTGGNGGAGGDAGDAG Mflv_5091|M.gilvum_PYR-GCK G---------GSGSAGKAG--ATGAAGASG-GKGAQGATGAQG------- Mvan_1264|M.vanbaalenii_PYR-1 G---------GSGSAGTAG--VTGASGASG-GKGAQGATGAQG------- MMAR_5044|M.marinum_M GDGGLLWGSGGAGARGGQGGAGAGGIGGAGGGGGLFGGDGGAGGVGGTG- MSMEG_0868|M.smegmatis_MC2_155 T---------GTASQGGNGGPSWVQSGYGSTLGGNATGTATAG------- TH_3810|M.thermoresistible__bu V---------GAAVRSGNG----VFSGGG--------GTPSAG------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 G---------GVSTGVGVGSHVGGGISESLGGSGSVGGSTAVG------- MAV_4827|M.avium_104 ----------GHLPFPGAG----STPGGSGGGHLPTPGAGTPG------- Rv3508|M.tuberculosis_H37Rv --------GAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNG--- MUL_4367|M.ulcerans_Agy99 --------GNGGNGGNGGQ-----------AFGDG--------------- Mb3541|M.bovis_AF2122/97 NGGNGNGTGNGGNGGNGGIAGMGGNGGAGTGSGNGGNGGSGGNGGNAGMG Mflv_5091|M.gilvum_PYR-GCK --------ATGAQGATG--------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 --------ATGAQGATG--------------------------------- MMAR_5044|M.marinum_M ------AGGPGGAGGVGGDAGLFGVGGAGGVGGTGVGFPTDPGLSFGGQG MSMEG_0868|M.smegmatis_MC2_155 ---------KGGEASNGG-------------------------------- TH_3810|M.thermoresistible__bu ---------FGVPTT----------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------GGAHTGVGGG------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv -----GDGDGFIGGSGGTGGTGGDAGVGGLANTGGTAGNAGIGGAGGRGG MUL_4367|M.ulcerans_Agy99 -----------VGGAGGIGGKGGNAAIGTIVING---------------- Mb3541|M.bovis_AF2122/97 GNSGTGSGDGGAGGNGGAAGTGGTGGDGGLTGTGGTGGSGGTGGDGGNGG Mflv_5091|M.gilvum_PYR-GCK -----------ATGAAGKAGATGAAGAAGAAGSAG--------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------ATGASGAQGSAGSAGSAGVAGSAG--------------- MMAR_5044|M.marinum_M GAGGRGGLLIGLGGNGGTGGFSGPLSAGAGGGDGGAGGGVGLIGFGGAGG MSMEG_0868|M.smegmatis_MC2_155 -----------VAGNGGNALVMAAGTTGVATGNTA--------------- TH_3810|M.thermoresistible__bu -----------IQFPAGSCTSRAVSREGIMPSSRA--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------VNTGVGVGSHVGGGISESLGGSGS--------------- MAV_4827|M.avium_104 ------------GGLGGFGGGHAPAPGGGLGGGGG--------------- Rv3508|M.tuberculosis_H37Rv DGGAGDSGAL----SQDGNGFAGGQGGQGGVGGNAGAGGINGAGGTGGTG MUL_4367|M.ulcerans_Agy99 --------------------------------------GVGGAGGSGGLG Mb3541|M.bovis_AF2122/97 NGGNGADNTANMTAQAGGDGGNGGDGGFGGGAGAGGGGLTAGANGTGGQG Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------TTGAQGSAGTN Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------TTGAQGSAGTN MMAR_5044|M.marinum_M FGGASGFGTG-------GAGGVGGAGGALFGVGGVGGNGAWGAGGIGGDG MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------------TGGDGGAATTA TH_3810|M.thermoresistible__bu ---------------------------------------ASARAGAACAS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------VGGSTAVGGGA MAV_4827|M.avium_104 --------------------------------------HAPAPGGGLGGF Rv3508|M.tuberculosis_H37Rv GAGGDGQNGTTG--------------------VASEGGAGGQGGDGGQGG MUL_4367|M.ulcerans_Agy99 GATEDG-------------------------------------------- Mb3541|M.bovis_AF2122/97 GAGGDGGNGAIGGHGPLTDDPGGNGGTGGNGGTGGTGGAGIGSLGGGTGG Mflv_5091|M.gilvum_PYR-GCK GANGAN-------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GANGAN-------------------------------------------- MMAR_5044|M.marinum_M GVGGAGSALGFG------------------------------LGGAGGAG MSMEG_0868|M.smegmatis_MC2_155 GATGGA-------------------------------------------- TH_3810|M.thermoresistible__bu STSRSR-------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 HTSAIN-------------------------------------------- MAV_4827|M.avium_104 GGGHSG-------------------------------------------- Rv3508|M.tuberculosis_H37Rv IGGAGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGDPS-IDGGQGGAGG MUL_4367|M.ulcerans_Agy99 -------------------VGGVGCAGGAG-------------------- Mb3541|M.bovis_AF2122/97 DGGNGGTGGNGGTGGEGGEVGGAGGTGGAAGNGGDGGTGGTGGGDGGAGG Mflv_5091|M.gilvum_PYR-GCK --------------------GSQGAAGKAG-------------------- Mvan_1264|M.vanbaalenii_PYR-1 --------------------GSQGAAGKAG-------------------- MMAR_5044|M.marinum_M GASGLGDGGAGGTGGAGGLLGGNGGGGGAGGAGAVG---FLDNTADGAGG MSMEG_0868|M.smegmatis_MC2_155 --------------------GGFSNIAAIHGAITDS-------TAISGHG TH_3810|M.thermoresistible__bu --------------------RSFCCSRA---------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------DALGGSGSVG-------------------- MAV_4827|M.avium_104 --------------------GGLGGLGGGHK------------------- Rv3508|M.tuberculosis_H37Rv HGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGAGGLG--GGGGTGG MUL_4367|M.ulcerans_Agy99 --GNGGRGDMLFT-----------VGGSGGTGGDGGGGGSA--SGSGTGG Mb3541|M.bovis_AF2122/97 TGGTGGTGGLGDPRVGGSG-GDGGTGGSGGAAGNGGNGGNAGAGGNGNGG Mflv_5091|M.gilvum_PYR-GCK -----ATG----------------TTGATGAAGEDGDAGSG--GSGINGG Mvan_1264|M.vanbaalenii_PYR-1 -----ATG----------------TTGATGAAGDAGDPGSE--AVDINGG MMAR_5044|M.marinum_M AGGAGGSGGLLFG-----------DGGVGGAGGAGGISTSSSVNNGGAGG MSMEG_0868|M.smegmatis_MC2_155 GAGNGGNGGKGADG-------WVQAYDPAGPVGSKIANSSAVAGNGGDGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------------GSTAVGGGAHTSAINESMNSS MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv TNG-NGGLGGGGGNGGAGGAGGTPTGSGTEGTGGDGGDAGAGGNGGSATG MUL_4367|M.ulcerans_Agy99 SGG-TGGVGGIGGDGKLG-------------------------------- Mb3541|M.bovis_AF2122/97 TGG-AGGIGGTGGNGGDAEPGVPPGAGGAGGAGTTGGKGGTGGNGSGTGS Mflv_5091|M.gilvum_PYR-GCK AGG-AGGAGGEGGEGGDG-------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 AGG-AGGAGGEGGEGGAG-------------------------------- MMAR_5044|M.marinum_M AGGNAGGLFGSGGAGGIG-----------GAVGTGGTVAGAGGDGGGAGW MSMEG_0868|M.smegmatis_MC2_155 VNGTGGASGGDGGNGGNTS----------------VWKSGGQTADGEHNT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 INASHSSSMNES-------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv VGNGGNGGDGGNGGDGGNGAPGGFG------GGAGAGGLGGSGAGGGTDG MUL_4367|M.ulcerans_Agy99 ----GFGGDGGDGGDGGFGVIGGQG------GGGGFGGLGGTGAGG-APS Mb3541|M.bovis_AF2122/97 GGTGGDGGTGGGGGNGGTGWNGGKGDTG-SGGGAGDGGKAPAGGTGGAGG Mflv_5091|M.gilvum_PYR-GCK ----GKGGAGAEGGAGGGGGAGGSG-------AGGAGGAGGSGGSGGSGG Mvan_1264|M.vanbaalenii_PYR-1 ----GAGGDGSEGGAGGSGGAGGSG-------TGGAGGAGGSGGSGGSGG MMAR_5044|M.marinum_M VGNAGNGGAGGDGWTNGNGGDGGDGGDVGLFGAGGNGGNGGTGVTAGTGG MSMEG_0868|M.smegmatis_MC2_155 GGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----FGSSMGSHGAAGTG-------------------FEAQGHAQGHAS MAV_4827|M.avium_104 -------------------------------------------------- Rv3508|M.tuberculosis_H37Rv DDGNGGSPGTDGS--- MUL_4367|M.ulcerans_Agy99 DKGINGEPGNPG---- Mb3541|M.bovis_AF2122/97 DGGAGGKGGSGGV--- Mflv_5091|M.gilvum_PYR-GCK SGGSGGAAGDSDD--- Mvan_1264|M.vanbaalenii_PYR-1 AGGSGGAAGDSD---- MMAR_5044|M.marinum_M TGGSGGLLGPDGINGS MSMEG_0868|M.smegmatis_MC2_155 ADGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu ---------------- MLBr_01183|M.leprae_Br4923 ---------------- MAB_4284c|M.abscessus_ATCC_199 ETAHTTLPGAEHH--- MAV_4827|M.avium_104 ----------------