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LTYVVVSPEIVAAAAGTLTRISSSVSAANAAAAASTTDLLAAGADEVSTRIAALFGVHGLEYQHISAQAA AYHEQFIQAMQGGARSYAWAEAANAEQNLLNLINSPTQAFFGRSLIGDGANATTPGGAGGDGGLLIGNGG NGAAGAAGQAGGAGGSGGLLGNGGNGGAGGIGGGAGGVGGNGGWLYGRGGVGGAGGMGGGTGGAGGHAWL FGHGGTGGLGGGGGIGAGGAGGNGGLLYGHGGAGAAGGAGQAGGDGGSAGLWGRGGAGGAAGVGGSTGGS GGNGGLLIGAGASGGAGTSGGAGGHGGWLIGDGGPGGTGGDGGGSGGSGGDAAWLFGNGGAGGAGGIGGG TGGQGGDGGFLIGNAGSGGIGGIGATGTPGGHGGDGGNPGWLLGAAGTGGLGGAGGAAASTGTAGGVGGD GGAGGRGGLFMHGGAGGNGGTGGAGAGGTDGGGSGGAGGAGGNGGAGGRAPLLFGRGGTGGYGGSGGSGG HGGTGLDGNLAGLGGDGGGGGTGGDGGAPGTGGAGGARHLFSHNGRSGSTGIGGAGGSGGRGGDGAAGTD AAANSGAIGGTGFSGGAGGAGGVGGGAGANQGAGGQGGDGGTGGTGGDGGDGAAGTDPLLAAQAGGQGGD GGTGGTAGTGGTGSTMGTDGTAGDGGTGGAGGHGGTGADNTTVVGAGAMGAAGGQGGAGGTGGTGGAAGT GGGGLQGAGGQGGDGGTGGTGGDGGDGAAGTDPLLAAQAGGQGGDGGTGGTAGTGGTGSTMGTDGTAGDG GTGGAGGHGGTGADNTTVVGAGAMGAAGGQGGAGGTGGTGGAAGTGGGGLQGAGGQGGDGGTGGTGGDGG DGAAGTDPLLAAQAGGQGGDGGTGGTAGTGGTGSTMGTDGTAGDGGTGGAGGHGGTGADNTTVVGAGAMG AAGGQGGAGGTGGTGGAAGTGGGGLQGAGGQGGDGGTGGTGGDGGDGIDNSTDMTGKAGGDGGQGGDGGT GGTAGTGGTGSTMGATGTGGTGGVGGSGGTGGHGGHGPLNSDPGGAGGKGGDGGTGGTGGAGIGTSGGGT GGDGGAAGDGGTGGDGGEVGGTGGVGGAAGTGGDGGDGGTGGGDGGKGGTGGTGGTGGIGDPRVGGSGGD GGAGGIGGVAGAGGQGGNAGAGGNGTGGDGGNGGIGGTGGVGGDAEPGAGGNGGAGGHGGTGGAAGAGGS GSGSGADGSSGMGGTGGQGGDGGAGSTGANAANGSGATGKAGFAGGKGGGGGDGGAGIGGVGGGDGGNGG SGGLGGDGGNGGSGGTNQTGGKGGAGGTGGDGGAAGAGGAGGGANGSGGTGGTGGTGGDGGKGGTVTGNG KAGTTGGAGGAGGAGGAGGDGIGSTGGGTGGVGGNAGDGGDGGNGSNGGNGNSDGGTGGTGGAAGAGGTG GVGGSGGGDGGAAGAGGTGGNGGKGGNARLNGNGDGGMGGQGGAAGTGGIGGAAGAGGNGNGGAGGTGGV GGGGGDGGTGGSSGKGGDGGTGGTGAVGGMGGAGGSGTGTGTGGTGGDGGDGGDGGDGGGGDGGAIPGTG GGDGGSGDTGNLPVGVTGGTGGTGGTAGTAGAGGLT
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_4999 | - | - | 100% (1576) | PE-PGRS family protein |
M. marinum M | MMAR_1594 | - | 0.0 | 53.85% (1872) | PE-PGRS family protein |
M. marinum M | MMAR_4316 | - | 0.0 | 49.26% (1831) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3541 | PE_PGRS55 | 0.0 | 58.93% (1690) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 0.0 | 48.48% (858) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3508 | PE_PGRS54 | 0.0 | 50.03% (1907) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 1e-12 | 38.04% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 3e-53 | 32.12% (551) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 8e-26 | 44.75% (181) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-167 | 41.40% (1058) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 2e-46 | 41.70% (283) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 47.90% (1142) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 0.0 | 48.82% (850) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_4999|M.marinum_M --------------------------------MTYVVVSPEIVAAAAG-- Mb3541|M.bovis_AF2122/97 --------------------------------MSFVLISPEVVSAAAG-- Rv3508|M.tuberculosis_H37Rv --------------------------------MSFVLIAPEFVTAAAG-- MUL_4367|M.ulcerans_Agy99 --------------------------------MSFVSVGPGLLEAAAR-- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M TLTRISSSVSAANAAAAASTTDLLA-----AGADEVSTRIAALFGVHGLE Mb3541|M.bovis_AF2122/97 DLANVGSTISAANKAAAAATTQVLA-----AGADEVSARIAALFGMYGLE Rv3508|M.tuberculosis_H37Rv DLTNLGSSISAANASAASATTQVLA-----AGADEVSARIAALFGGFGLE MUL_4367|M.ulcerans_Agy99 DLAGLGAGLREANLAAAGATVGVLP-----AAGDEVSAAIAELFGGFGRE Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------MVTFGGGA-- Mvan_1264|M.vanbaalenii_PYR-1 ----MMFLAPPGGPGPISAAIQLTS-----TGSEATEPWYVVSFGGSG-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -MSIIDFILNLFRDPVEAASYVADP------EAALANAGLSAVSAAQVGA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAA MMAR_4999|M.marinum_M YQHISAQAAAYHEQFIQAMQGGARSYAWAEAAN------AEQNLLNLINS Mb3541|M.bovis_AF2122/97 YQAISAQVAAYHQQFVQTLRTGAASYMLAEATN------VEQNLLNLINA Rv3508|M.tuberculosis_H37Rv YQAISAQVAAYHQRFVQALSTGAGAYASAEAA------AAEQIVLGVINA MUL_4367|M.ulcerans_Agy99 YQAMGARVALLHDDFVRALTAGGSAYGQAEALNMWPLQELEQQALGVVNA Mflv_5091|M.gilvum_PYR-GCK -TPTPTSLGAAAVDLSGTSCG----------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -APTPNNLAASLVDLSGTSCG----------------------------- MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VMPVVAESVASNYGYQSQWVN----------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 TASAPDRVISAILGTREG-------------------------------- MMAR_4999|M.marinum_M PTQ----------------------------------------------- Mb3541|M.bovis_AF2122/97 PTQ----------------------------------------------- Rv3508|M.tuberculosis_H37Rv PTQ----------------------------------------------- MUL_4367|M.ulcerans_Agy99 PSM----------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M ----------------------------------AFFGRSLIGDGAN-AT Mb3541|M.bovis_AF2122/97 ----------------------------------TLLGRPLIGDGAN-AT Rv3508|M.tuberculosis_H37Rv ----------------------------------ALLGRPLIGDGAN-AT MUL_4367|M.ulcerans_Agy99 ----------------------------------ALFGRPSIGNGVDGVA Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------LICNGQD--- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------LICNGQD--- MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGIN-GT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M TPGGAGGDGGLLIGNGGNGA-AGAAGQAGGAGGSGGLLG-NGGNGGAGGI Mb3541|M.bovis_AF2122/97 TPGGAGGDGGLLFGSGGNGA-PGAPGQAGGAGGSAGLLG-NGGSGGAGGT Rv3508|M.tuberculosis_H37Rv TPGGAGGAGGLLFGNGGAGA-AGAPGQAGGPGGPAGLWG-NGGPGGAGGS MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIG-TGGVGGAGG- Mflv_5091|M.gilvum_PYR-GCK ---GTGQNGGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNG-- Mvan_1264|M.vanbaalenii_PYR-1 ---GTGQNGGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNG-- MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------TGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDND------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----AADAGLQLSSIGVTWTDQLEAAALRDALAARRID----------- MMAR_4999|M.marinum_M GGGAGGVGGNGGWLYGRGGVGGAGGMGGGTGGAGG-HAWLFGHGGTGGLG Mb3541|M.bovis_AF2122/97 G-APGGNGGNAGWLYGRGGVGGAGGIGGGTGGAGG-HAWLFGHGGTGGIG Rv3508|M.tuberculosis_H37Rv GGGTGGAGGAGGWLFGVGGAGGVGGAGGGTGGAGGPGGLIWGGGGAGGVG MUL_4367|M.ulcerans_Agy99 ----------------VGAAG----MTGGSGGAGGGGGWLWGAGGSGGAA Mflv_5091|M.gilvum_PYR-GCK -------------------------LGGGNGGNGG-NAGAFALFGNG--- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------LGSGDGGNGG-DAGLFSLFGRG--- MSMEG_0868|M.smegmatis_MC2_155 G------------------------LDGGNGGSGGLLMGIGGAGGAGGVG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------FLSHNDTDFASHNPIASGN------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------NVMLVSAFLAAAALAQNVGGAMG----- MMAR_4999|M.marinum_M GGGGIGAGGAGGNGGLLYGHGGAGAAGGAGQAGGDGGSAGLWGRGGAGGA Mb3541|M.bovis_AF2122/97 GG-------PGGNGGWLLGNGGHGGAGGIG-------------------- Rv3508|M.tuberculosis_H37Rv GAGGG-TGGAGGRAELLFGAGGAGGAGTDG-------------------- MUL_4367|M.ulcerans_Agy99 GAGG---------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M AGVGGSTGGSGGNGGLLIGAGASGGAGTSGGAGGHGGWLIGDGGPGGTG- Mb3541|M.bovis_AF2122/97 --------------------------GGSGGAGGNGGWLLGNGGIGGAG- Rv3508|M.tuberculosis_H37Rv ------------------GPGATGGTGGHGGVGGDGGWLAPGGAGGAGGQ MUL_4367|M.ulcerans_Agy99 -------------------------------SGGSGGWLWG--------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------ADGTSAHVDG--------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M GDGGGSGGSGGDAAWLFGNGGAGGAGGIGGGTGGQGGDGG--FLIGNAGS Mb3541|M.bovis_AF2122/97 GTGGGAGGTGGNAAWLLGGGGTGGAGGIGGGNGGHGGNGG--WLLGNGGN Rv3508|M.tuberculosis_H37Rv GGAGGAGSDGGALGGTGGTGGTGGAGGAGGRGALLLGAGGQGGLGGAGGQ MUL_4367|M.ulcerans_Agy99 -----------------NAGQTAGAG-----------------VGGAGGA Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------------GNGGN Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------------------------GNGGN MSMEG_0868|M.smegmatis_MC2_155 -----------------GTGGTGGTG------------------GGTGGT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------QVMSPS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------------------------------YERT MMAR_4999|M.marinum_M GGIGGIGATGTPGGHGGDGGNPGWLLGAAGTGGLGGAGGAAASTGTAGGV Mb3541|M.bovis_AF2122/97 GGLGGDGDGGTGGGHGGNGGNPGWLLGTAGGGGNGGAGSTGTAGGGSGGT Rv3508|M.tuberculosis_H37Rv GGTGGAGGDGVLGGVGGTGGK-GGVGGVAGLGGAGGAAGQLFSAGGAAGA MUL_4367|M.ulcerans_Agy99 GGAGDAGDQGVSG------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGVGVVGATGAVG------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GGVGIAGATGAVG------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GGIGGTGG-GLFGLLG---------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GNVDSFNRGPLLDLSFG--------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AVLLVEPDTATLAVVETS-------------------------------- MMAR_4999|M.marinum_M GGDGGAGGRGGLFMHGGAGGN--GGTGGAGAGGTDGGGSGGAGGAGGNGG Mb3541|M.bovis_AF2122/97 GGDGGTGGRGGLLMGAGAGGH--GGTGGAGGAGVDGGGAGGAGGAGGNGG Rv3508|M.tuberculosis_H37Rv VGVGGTGGQGGAGGAGAAGADAPASTGLTGGTGFAGG-AGGVGGQGGNAI MUL_4367|M.ulcerans_Agy99 -----------------------VAPGEAGAVGFAGG-AGGAGGAGGNGV Mflv_5091|M.gilvum_PYR-GCK ------------------------APGVAGATGATGVTSGVVGGNGEDAV Mvan_1264|M.vanbaalenii_PYR-1 ------------------------APGVAGATGATGVTSNVTGGNGADAV MSMEG_0868|M.smegmatis_MC2_155 ------------------------HSGSTGAAGAAGNGGDGGNGGFGYVL TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------DLQFGNRDTTAIGDGAVAVGGSNSGPI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------DGSIPDVYKQQIRAESYGDAAGQLSAM MMAR_4999|M.marinum_M AGGRAPLLFGRGGTGGYGGSGGSGGHGGTGLDGNLAGLGGDGGGGGTGGD Mb3541|M.bovis_AF2122/97 AGGQAALLFGRGGTGGAGGYGGDGGGGGDGFDGTMAGLGGTGGSGGTGGD Rv3508|M.tuberculosis_H37Rv AGG----INGSGGAGGTGGQGGAGGMGGSGADN-ASGIGADGGAGGTGGN MUL_4367|M.ulcerans_Agy99 GGG----VNGAGGAGGAGGVGGGGGAGASGVG-----AGVAGGDGGTGGA Mflv_5091|M.gilvum_PYR-GCK GYG------ATGAAGAAGAAGAAGAAGAVGSAG----AAGEAGETGTWGN Mvan_1264|M.vanbaalenii_PYR-1 GYG------ATGAAGAAGAAGAAGKAGAVGSAG----TAGSAGAPGVWGN MSMEG_0868|M.smegmatis_MC2_155 IAG----PNVTVGSETRGGTGGAGGTGGQSTAA-----GPGKGGGGGGGG TH_3810|M.thermoresistible__bu -------------------VDGDGGSG----------------------- MAB_4284c|M.abscessus_ATCC_199 ASG-------QGSTAVNGDVRDSNIINADHGSN----VGVDQSQTRVGGD MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VAG------LEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEP MMAR_4999|M.marinum_M GGAPGTGGAGGARHLFSHNGRSGSTGIGGAGGSGGRGGDGAAGTDAAANS Mb3541|M.bovis_AF2122/97 GGAPGNGGAGGAGQLLSHSGVAGASGKGGAGGTGGNGGAGSAGADAPAGS Rv3508|M.tuberculosis_H37Rv AGAGGAGGAAGTGGTGGVVGAAGKAGIGGTGGQGGAGGAGSAGTDATA-T MUL_4367|M.ulcerans_Agy99 GGAAGVGGAAGTGGTG------GAAGVAGTGGDGGDGGAGGAGSDASL-A Mflv_5091|M.gilvum_PYR-GCK AGLPGKAGDAGGAGAVGAAGAAGTVGTAGATGGTGTGANGGAGG-----V Mvan_1264|M.vanbaalenii_PYR-1 AGLPGAAGAAGGAGAIGTAGVAGAAGTAGATGGTGVGGNGGAGQ-----A MSMEG_0868|M.smegmatis_MC2_155 GGAILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGR---VIA TH_3810|M.thermoresistible__bu ----------------------GRTGLFSKLSRGGDGGDG---------- MAB_4284c|M.abscessus_ATCC_199 YTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTNIGS------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ETALARGAALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVPVD MMAR_4999|M.marinum_M GAIGGTGFSGGAGGAGGVGGGAGANQGAGGQGGDGGTGGTGGDGGDGAAG Mb3541|M.bovis_AF2122/97 GAMGSTGFAGGAGGDGGNGGGSGASQGNGGNGGNGGTGGKGGTGGAGMNS Rv3508|M.tuberculosis_H37Rv GATGGTGFSGGAGGAGGAGGNTGVG-GTNGSGGQGGTGGAGGAGGAGGVG MUL_4367|M.ulcerans_Agy99 GQAG---FAGGSGGAGGVGGSAGAG-GVNGSGGDGGAGAAGGAGGASAT- Mflv_5091|M.gilvum_PYR-GCK GGVGGTGAAGAAGGAGGLG-ETGTTGGAGGVGGQGTAGGTGGVGGIGGAG Mvan_1264|M.vanbaalenii_PYR-1 GGIGGTGAAGAAGQAGTAG-ETGVTGGVGGIGGQGTEGGTGGVGGVGGVG MSMEG_0868|M.smegmatis_MC2_155 EGTGSTAEGTATGGDGGHSTGTGIG-GNGGIGSVYAYGNNGAVSGTATGG TH_3810|M.thermoresistible__bu --------------------------GLGGNGGHG--GGTGIISLLSLAG MAB_4284c|M.abscessus_ATCC_199 --GNTTNTEIGSHNQANIGTSTSAGGSAAVGGNAGLAGNAGLAGNAGLAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PEPGDDELAYSAVGEEDAESPTVVIEKLFLPEDSEPRRRPVLLVGSGLAV MMAR_4999|M.marinum_M -TDPLLAAQAGGQGGDGGTGGTAGTGG---TGSTMGTDGTAGDGGTGGAG Mb3541|M.bovis_AF2122/97 -LDPLLAAQDGGQGGTGGTGGNAGAGG---TGFTQGADGNAGNGGDGGVG Rv3508|M.tuberculosis_H37Rv ADNPTGIGGTGGTGGKGGAGGAGGQGGSSGAGGTNGSGGAGGTGGQGGAG MUL_4367|M.ulcerans_Agy99 ------VAGSGGVGGDGGAGGAAG-------------------------- Mflv_5091|M.gilvum_PYR-GCK --------STGAVGGVGGKGIQG--------------------------- Mvan_1264|M.vanbaalenii_PYR-1 --------ATGGAGGVGGKGIQG--------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------RGGDGIDGGTGGAGGMGEIYS----------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VG------------------------------------------------ MMAR_4999|M.marinum_M GHGGTGADN-TTVVGAGAMGAAGGQGGAGGTGGTGGAAGTGGG-GLQGAG Mb3541|M.bovis_AF2122/97 GNGGNGADN-TTTAAAGTTGGAGGAGGAGGTGGTGGAAGTGTG-GQQGNG Rv3508|M.tuberculosis_H37Rv GAGGAGADNPTGIGGAGGTGGTGGAAGAGGAGGAIGTGGTGGAVGSVGNA MUL_4367|M.ulcerans_Agy99 --------------------------------------------GGVGAA Mflv_5091|M.gilvum_PYR-GCK -----------------------------------------------GQG Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------------------GQG MSMEG_0868|M.smegmatis_MC2_155 ----------------------------GADGEATGISAGGDGGSATGAD TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------------------------ISAVLALEIA MMAR_4999|M.marinum_M GQGGDGGTGGTGGDGGDGAAG-TDPLLAAQAGGQGGDGGTGGTAGTGGTG Mb3541|M.bovis_AF2122/97 GNGGNGGTGGKGGTGGAGMNS-LDPLLAAQDGGQGGTGGTGGNAGAGGTG Rv3508|M.tuberculosis_H37Rv GIGGTGGTGGVGGAGGAGAAAAAGSSATGGAGFAGGAGGEGGAGGNSGVG MUL_4367|M.ulcerans_Agy99 SLGGDGGHAGAGGAGGEGLSGGFNTGAAGGIGGAGGAGGTGGDSG--GVG Mflv_5091|M.gilvum_PYR-GCK LQGGKGGDGGAGGKGGD----------ADSMGSAGATGGKGGNGGNGGRG Mvan_1264|M.vanbaalenii_PYR-1 LQGGQGGDGGTGGTGGD----------ATSMGEAGATGGKGGNGGNGGRG MSMEG_0868|M.smegmatis_MC2_155 SLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDALVM TH_3810|M.thermoresistible__bu -NGGNGGNG------------------YRTTDNNALDGGHGGNGGNVGFF MAB_4284c|M.abscessus_ATCC_199 -NAGLAGNAGLAGNAG-----------LAGNAGLAGNAGLAGNAGLAGNA MLBr_01183|M.leprae_Br4923 ---------------------------MPLFLNAEPQALTAAANTLEGLS MAV_4827|M.avium_104 LAIGIRTTGTVALQPTPNQHLIVPTEQAPAPPPVQASAPQPKISVPEPVA . MMAR_4999|M.marinum_M STMGTDGTAGDGGTGGAGGHGGTGADNTTVVGAGAMGAAGGQGGAGGTGG Mb3541|M.bovis_AF2122/97 FTQGADGNAGNGGDGGVGGNGGNGADNTTTAAAGTTGGAGGAGGAGGTGG Rv3508|M.tuberculosis_H37Rv GTNGSGGAGGAGGKGGTGGAGGSGAD--NPTGAGFAGGAGGTGGAAGAGG MUL_4367|M.ulcerans_Agy99 GVNGDGGAGGGGGRGGDGGSSTS------TSGVGGAGGAGGNGGNAGFGV Mflv_5091|M.gilvum_PYR-GCK GLFGKGGNAGNGADGGTGGAGGA-------------GGTGGTGGAGGTGG Mvan_1264|M.vanbaalenii_PYR-1 SLFGRGGNAGNGGNGGTGGNGGN-------------GGTGGTGGNGGTGG MSMEG_0868|M.smegmatis_MC2_155 AAGATGVATGNTAIGGNGGAASAN------------GAVGGNGGFTNIAA TH_3810|M.thermoresistible__bu SLFNLGGAGGWGGSGVDG-----------------VDVVGGNPDGGTPG- MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAGLAGNAGLAGN-------------AGLAGNAGLAGNAG MLBr_01183|M.leprae_Br4923 AATVASNAAAAQLT----------------------------TEIAPP-- MAV_4827|M.avium_104 APKPLSPPVAAPLPAAPPPAAPP------------LPEAPPIPAAPPVVP . MMAR_4999|M.marinum_M TGGAAGTGG-GGLQGAGGQGGDGGTGGTGGDGGDGAAGTDPLLAAQAGGQ Mb3541|M.bovis_AF2122/97 TGGAAGTGT-GGQQGNGGNGGNGGTGGKGGTGGAGMNSLDPLLAAQDGGQ Rv3508|M.tuberculosis_H37Rv AGGATGTGGTGGVVGATGSAGIGGAGGRGGDGGDGASGLGLGLSGFDGGQ MUL_4367|M.ulcerans_Agy99 SAGGTG-----------GSAGDGGAGG----------------------- Mflv_5091|M.gilvum_PYR-GCK TG---------------GTGGIGGAGSTG--------------------- Mvan_1264|M.vanbaalenii_PYR-1 TG---------------GTGGIGGAGSTG--------------------- MSMEG_0868|M.smegmatis_MC2_155 IHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LAGN---------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VPVVVP-------------------------------------------- MMAR_4999|M.marinum_M GGDGGTGGTAGTGGTGSTMG--TDGTAGDGGTGGAGGHGGTGADNTTVVG Mb3541|M.bovis_AF2122/97 GGTGGTGGNAGAGGTGFTQG--ADGNAGNGGDGGVGGNGGNGADNTTTAA Rv3508|M.tuberculosis_H37Rv GGQGGAGGSAGAGGINGAGG--AGGNGGDGGDGATGA-----------AG MUL_4367|M.ulcerans_Agy99 ----------GAGGVDGVGG--ASGNGGAAGAGGAGG-----------SG Mflv_5091|M.gilvum_PYR-GCK ----------GTGGTGGTGG--TGGTGGTGGTGGTGG------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------GTGGTGGTGG--TGGTGGTGGTGGTGG------------- MSMEG_0868|M.smegmatis_MC2_155 ----------GPAGTTIDKGKAAGGNGGDGGFNGTGG------------- TH_3810|M.thermoresistible__bu -----------AHGESHTPGVYTDRQGEDGEDGTGTG------------- MAB_4284c|M.abscessus_ATCC_199 ---------AGLAGNAGLAG--NAGLAGNAGLAGNAG------------- MLBr_01183|M.leprae_Br4923 ----------AADDVSILLAHFFSGHGRQYQAHASQG------------- MAV_4827|M.avium_104 -----------PVPVPVPVRIPVPDPVSPPQLLAPPR------------- MMAR_4999|M.marinum_M AGAMGAAGGQGGAGGTGGTGGAAGTGGGGLQGAGGQGGDGGTGGTGGDGG Mb3541|M.bovis_AF2122/97 AGTTGGAGGAGGAGGTGGTGGAAGTGTGGQQGNGGNGGNGGTGGKGGTGG Rv3508|M.tuberculosis_H37Rv LGDNGGVGGDGGAGGAAGNGGNAGVGLTAKAGDGGAAGNGGNGGAGGAGG MUL_4367|M.ulcerans_Agy99 IG----AGIDGGAGGAGGTGGAAGF-----PGGGGTTGAWGTGGAGGAGG Mflv_5091|M.gilvum_PYR-GCK ------TGGTGGKGGTGGTGG-----------AGGTGGDGGTGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 ------TGGTGGKGGTGGTGG-----------DGGTGGTGGTGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 -----ATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAG TH_3810|M.thermoresistible__bu ------IGGRGGNGGSS----------------SGTHPMAEDGEHVKALD MAB_4284c|M.abscessus_ATCC_199 ------LAGNAAVAGNAAVAG-----------NAAVAGNAAVGGVLNTGV MLBr_01183|M.leprae_Br4923 ------ATNHQDLIQSLLT---------------SSSAYAGTETANHDSL MAV_4827|M.avium_104 ------LSVPQPVQPPVRVPQ--------------PPSPPQVGGTVPQSP MMAR_4999|M.marinum_M DGIDN----------------------STDMTGKAGGDGGQGGDG----- Mb3541|M.bovis_AF2122/97 DGALAGSSGGAGGKGGNGGDAGKAGTGSAPGTAGTGGDGGKGGNGGIGAA Rv3508|M.tuberculosis_H37Rv AGDNNFNGGQGG--AGGQGGQGGLGGASTTSINANGGAGGNGGTGGKGGA MUL_4367|M.ulcerans_Agy99 AG------------------------------------------------ Mflv_5091|M.gilvum_PYR-GCK TG------------------------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 TG------------------------------------------------ MSMEG_0868|M.smegmatis_MC2_155 AN------------------------------------------------ TH_3810|M.thermoresistible__bu GR------------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 SG------------------------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PQ------------------------------------------------ MMAR_4999|M.marinum_M ------------GTGGTAGTGGTG---------STMGATGTGG------- Mb3541|M.bovis_AF2122/97 GTTGPVGTGASGGTGGSGGAGGTGGDGG-AANGGTAGAGGAGGNGGKGGD Rv3508|M.tuberculosis_H37Rv GGAGTLGVGGSGGTGGDGGDAGSGGGGGFGGAAGKAGGGGNGGRGGDGGD MUL_4367|M.ulcerans_Agy99 ------GAGDHGGVGVNPGDSGTAG------------------------- Mflv_5091|M.gilvum_PYR-GCK ------------GTGGTGGTGGAG-------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------GTGGTGGTGGAG-------------------------- MSMEG_0868|M.smegmatis_MC2_155 ------------GNGGAGGAGGVSEGEG---------------------- TH_3810|M.thermoresistible__bu -------------PGLDGGNGSHG-------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------AIGGSSHVGGAIN------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------HQTPPGEGTPPK------------------------- MMAR_4999|M.marinum_M ------------TGGVGGSGGTGGHGGHGPLNSDP--------------- Mb3541|M.bovis_AF2122/97 GGAGVTSSTAGNSGGAGGSGGKGGDAGAGGAGATPGANGIAGNGGDGGDG Rv3508|M.tuberculosis_H37Rv GASGLGLGLSGFDGGQGGQGGAGGSAGAGGINGAG--------------- MUL_4367|M.ulcerans_Agy99 -----------WAGGAGGAGGAGGSAAFNGVNGAG--------------- Mflv_5091|M.gilvum_PYR-GCK -------------DGTGGTGGTGGTGGQG--------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------DGLGGTGGTGGTGGFG--------------------- MSMEG_0868|M.smegmatis_MC2_155 -----------GTGGHGGDGGRGGDGALGGNGGTGGVG------------ TH_3810|M.thermoresistible__bu --------------GNGGHGGRGGFLGIG--------------------- MAB_4284c|M.abscessus_ATCC_199 -------------ESLGGSGSVGGSTAVG--------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------PDGPGNYGG-------------------------- MMAR_4999|M.marinum_M ------------------GGAGGKGGDGGTGGTGGAGIG---TSGGGTGG Mb3541|M.bovis_AF2122/97 AAGAVGISGATGAGDGGHGGTGGAGGNGGTGGAGGSGID---GVGGGTGG Rv3508|M.tuberculosis_H37Rv -------------------GAGGNGGDGGDGATGAAGLGD-NGGVGGDGG MUL_4367|M.ulcerans_Agy99 -------------------GAGGNGGAGGGGGAGASGIG--AGVAGGDGG Mflv_5091|M.gilvum_PYR-GCK -------------------GQGGQGGTGGTGGQGGLG------GGGGTGG Mvan_1264|M.vanbaalenii_PYR-1 -------------------GQGGQGGTGGTGGQGGLG------GVGGTGG MSMEG_0868|M.smegmatis_MC2_155 ------------------LGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGG TH_3810|M.thermoresistible__bu -------------------GSGGWGGHGGNGGDTDAD--------GGNGG MAB_4284c|M.abscessus_ATCC_199 ---------------------GGAHTGVGGGVSTGVG-------VGSHVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------GHVPTPGAGGSGGSGGGHVP----------- MMAR_4999|M.marinum_M DGGAAGDGG--------TGGDGGEVGGTG---------------GVGGAA Mb3541|M.bovis_AF2122/97 TGGNGGNGA--------IGGAGGDAGGSGNSGGNGGTGGKGGNAGAGGAA Rv3508|M.tuberculosis_H37Rv AGGAAGNGGNAGVGLTAKAGDGGAAGNGGN-------------GGAGGAG MUL_4367|M.ulcerans_Agy99 TGGTGG-----------AAGTGGAAGTGGT-------------GGAAGAA Mflv_5091|M.gilvum_PYR-GCK QGGTGG-------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 TGGTGG-------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NGGAGRIRVN--------NGTATGTATGGN-------------------- TH_3810|M.thermoresistible__bu DG------------------------------------------------ MAB_4284c|M.abscessus_ATCC_199 GGISES-------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M G----------TGGDGGDG----------------GTGGGDGGKGGT-GG Mb3541|M.bovis_AF2122/97 GSNGGTVGANGTGGDGGNGGAAGAATAGSNGGAGTGSAGGNGGTGGR-GG Rv3508|M.tuberculosis_H37Rv GAGDNNFNG-GQGGAGGQGGQGGLGGASTTSINANGGAGGNGGTGGK-GG MUL_4367|M.ulcerans_Agy99 GS------------------------------------AGDGGAGGA-GG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------TGGQGGTGGT-GG Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------TGGQGGTGGT-GG MSMEG_0868|M.smegmatis_MC2_155 -----------------------------------GGNGGNGDADGHRGG TH_3810|M.thermoresistible__bu ---------------------------------------GNGGSAGR--- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------LGGSGSVGGS--- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------TPGAGGSGGS--- MMAR_4999|M.marinum_M TGGTGG--IG-----------DPRVGGSGGDGGAG---------GIGGVA Mb3541|M.bovis_AF2122/97 SGGAGGDGIGGVGGGKGGNGADGEVGGAGGAGGSGPNTSPGGNGGQGGQG Rv3508|M.tuberculosis_H37Rv AGGAGTLGVGGS----------GGTGGDGGDAGSG---GGGGFGGAAGKA MUL_4367|M.ulcerans_Agy99 AGDDGSAGVVS------------------GDPG------------TAGKA Mflv_5091|M.gilvum_PYR-GCK TGGTGG-------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 TGGTGG-------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 KGGDGGEALIR-----------------------------------ATVI TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M GAGGQGGNAGAG-----GNGTGGDGGNGGIGGTGGVGGDAEPGAGGNGGA Mb3541|M.bovis_AF2122/97 GSGGAGGAAGAGGAGGGANGTAGNGGQGGAGGTGGAGAASSATNGGSGGA Rv3508|M.tuberculosis_H37Rv GGGGNGGVGGDGGEGASGLGLGLSGFDGGQGGQGGAG-----GSAGAGGI MUL_4367|M.ulcerans_Agy99 GGAG---------------------------GAGGVG-----GNGVAGGV Mflv_5091|M.gilvum_PYR-GCK --------------------------------TGGAG-----GDGGLGGL Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------TGGAG-----GDGGLGGL MSMEG_0868|M.smegmatis_MC2_155 GSNASG------------------------TATGGDGG----NGGTLGAT TH_3810|M.thermoresistible__bu -----------------------------------------------GGT MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------TAVGGGAH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------------------------------------GGGH MMAR_4999|M.marinum_M GGHGGTGGAAGAGGSGSGSGADGSSGMG---------------------- Mb3541|M.bovis_AF2122/97 GGTGGAGGTGGAGGDGVGGAGGGNGGHGGDAGDGGNGANGNNRSSGSFLA Rv3508|M.tuberculosis_H37Rv NGAGGAGGTGGAGGDGAPATLIGGPDGGDGGQGGIGGDGGNAGFGAGVPG MUL_4367|M.ulcerans_Agy99 NGSGGAGGAG---------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGFGGSGGTG---------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GGFGGVGGTG---------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 NGTGGAATIVAYNVVQANPQASG--------------------------- TH_3810|M.thermoresistible__bu GGLRGVFGIN---------------------------------------- MAB_4284c|M.abscessus_ATCC_199 TGVGGGVSTG---------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VPTPGTGGPG---------------------------------------- MMAR_4999|M.marinum_M ---------------------GTGGQGGDGGAGSTGAN------------ Mb3541|M.bovis_AF2122/97 AGGTGGAAGDGGQGGQGGAGGGAGGQGGAGGAGGTGGNGGNITGGTAGTA Rv3508|M.tuberculosis_H37Rv DGGDGGNAGFGAGVPGDGGIGGTGGAGGAGGAGADGDPS------IDGGQ MUL_4367|M.ulcerans_Agy99 ------------------------GAGGTGGAGASGVP------------ Mflv_5091|M.gilvum_PYR-GCK ------------------------GQGGLGGPG----------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------------GQGGQGGPG----------------- MSMEG_0868|M.smegmatis_MC2_155 -----------------------TATDGHGGSGIN--------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------VGVGSHVGGGIS--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M -AANGSGATGKAGFAG---------GKGGGGGDGGAG------------- Mb3541|M.bovis_AF2122/97 GAAGNGGAAGKGGAGGQGGTGGGTGGQGGAGGDGGAGGTGGDRTVGGGTV Rv3508|M.tuberculosis_H37Rv GGAGGHGGQGGKGGLNSTGLASAASGDGGNGGAGGAGGNGGD-------- MUL_4367|M.ulcerans_Agy99 -----------------------ASVDGGDGGAGGAGG------------ Mflv_5091|M.gilvum_PYR-GCK ---------------------------GSTGGAGGAG------------- Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------GSTGGAGGAG------------- MSMEG_0868|M.smegmatis_MC2_155 ---------------------------GGHGGNGGQGTIEAN-------- TH_3810|M.thermoresistible__bu ------------------------------GGNGRAG------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------ESLGGSGSVG------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------GTGGSG------------- MMAR_4999|M.marinum_M ---------------IGGVGGGDG-----------GNGGSGGLGGDGGNG Mb3541|M.bovis_AF2122/97 PAGSGGQGGNAGGGGAGGQGGADG-----------GSGGDGGDAGTGGNG Rv3508|M.tuberculosis_H37Rv --------GDGFIGGSGGTGGTGGDAGVGGLANTGGTAGNAGIGGAGGRG MUL_4367|M.ulcerans_Agy99 ---------------AAGTGGSG------------GSAGNTGAGGAGGAG Mflv_5091|M.gilvum_PYR-GCK -----------------------------------GQAGTAGKGGLFGGS Mvan_1264|M.vanbaalenii_PYR-1 -----------------------------------GQAGVAGKGGLFGGS MSMEG_0868|M.smegmatis_MC2_155 ----------------GPSAVASG----------IGAGGNGGDGIDGGLG TH_3810|M.thermoresistible__bu ------------------------------------LGGRGXXXXGGGVG MAB_4284c|M.abscessus_ATCC_199 --------------------------------------GSTAVGGGAHTG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------GGHVPTPGAGTPG MMAR_4999|M.marinum_M GSGGTN-----------------------------QTGGKGGAG------ Mb3541|M.bovis_AF2122/97 GNGGNRNSGNGTGGAGGNGGGGANGGAGGAGGSGGGTGGNGGAGGDAGDA Rv3508|M.tuberculosis_H37Rv GDGGAG-----------------------------DSGALSQDGNGFAGG MUL_4367|M.ulcerans_Agy99 GAGGSA-----------------------------ASTGVNGDG------ Mflv_5091|M.gilvum_PYR-GCK GSAGKA-------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GSAGTA-------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GNGGDG---------------------------VVNTTANAAN------- TH_3810|M.thermoresistible__bu AAVRS--------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VGGGVN-------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GSGGGHLP------------------------------------------ MMAR_4999|M.marinum_M -------------------------------------------------- Mb3541|M.bovis_AF2122/97 GNGGNGNGTGNGGNGGNGGIAGMGGNGGAGTGSGNGGNGGSGGNGGNAGM Rv3508|M.tuberculosis_H37Rv QGGQGGVGGNAGAGGIN--------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M -----------GTGGDGGAAGAGGAGG--GANGSGGTGGTGGTGGDGGKG Mb3541|M.bovis_AF2122/97 GGNSGTGSGDGGAGGNGGAAGTGGTGGDGGLTGTGGTGGSGGTGGDGGNG Rv3508|M.tuberculosis_H37Rv -----------GAGGTGGTGGAGGDGQN-GTTGVASEGGAGGQGGDGGQG MUL_4367|M.ulcerans_Agy99 -----------GAGGAGGVGGLGGDS--------AATAGGGGAGGDGGKG Mflv_5091|M.gilvum_PYR-GCK -------------GATGAAGASGGKG---------AQGATGAQGATGAQG Mvan_1264|M.vanbaalenii_PYR-1 -------------GVTGASGASGGKG---------AQGATGAQGATGAQG MSMEG_0868|M.smegmatis_MC2_155 -------------PGSATGTATGGDG--------GKATGTASQGGNGGPS TH_3810|M.thermoresistible__bu --------------GNGVFSGGGGTP------------------------ MAB_4284c|M.abscessus_ATCC_199 -------------TGVGVGSHVGGGIS----------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------FPGAGSTPGGSGGG------------------------ MMAR_4999|M.marinum_M GT-----------------------------VTGNGKAG----TTGGAGG Mb3541|M.bovis_AF2122/97 GNGGNGADNTANMTAQAGGDGGNGGDGGFGGGAGAGGGG----LTAGANG Rv3508|M.tuberculosis_H37Rv GIGG---------------------------AGGNAGFGAGVPGDGGIGG MUL_4367|M.ulcerans_Agy99 GAGG---------------------------AGVNGVGG----GDGGKGG Mflv_5091|M.gilvum_PYR-GCK ATG----------------------------------------ATGAAGK Mvan_1264|M.vanbaalenii_PYR-1 ATG----------------------------------------ATGASGA MSMEG_0868|M.smegmatis_MC2_155 WVQSG--------------------------YGSTLGGNATGTATAGKGG TH_3810|M.thermoresistible__bu --------------------------------------------SAGFGV MAB_4284c|M.abscessus_ATCC_199 ---------------------------------------------ESLGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------------------------------------HLPTPG MMAR_4999|M.marinum_M AGGAGGAGGDG----IGSTG------GGTGGVGGNAGDG----------- Mb3541|M.bovis_AF2122/97 TGGQGGAGGDGGNGAIGGHGPLTDDPGGNGGTGGNGGTGGTGGAGIGSLG Rv3508|M.tuberculosis_H37Rv TGGAGGAGGAGADGDPSIDG-------GQGGAGGHGGQGGKGGLNSTGLA MUL_4367|M.ulcerans_Agy99 TGGAGGAGGAGSDGIIPSNG-------GLGGNGGNGGNGGQ--------- Mflv_5091|M.gilvum_PYR-GCK AGATGAAGAAGAAGSAGTTG-------AQGSAGTNGANG----------- Mvan_1264|M.vanbaalenii_PYR-1 QGSAGSAGSAGVAGSAGTTG-------AQGSAGTNGANG----------- MSMEG_0868|M.smegmatis_MC2_155 EASNGGVAGNGGNALVMAAG-------TTGVATGNTATG----------- TH_3810|M.thermoresistible__bu PTTIQFPAGSCTSRAVSREG------------------------------ MAB_4284c|M.abscessus_ATCC_199 SGSVGGSTAVGGGAHTSAIN------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AGTPGGGLGGFGGGHAPAPG------------------------------ MMAR_4999|M.marinum_M ----GDGGNGSNGGNGNSDG-------GTGGTGGAAGAGGTGGVGGSGG- Mb3541|M.bovis_AF2122/97 GGTGGDGGNGGTGGNGGTGGEG-GEVGGAGGTGGAAGNGGDGGTGGTGG- Rv3508|M.tuberculosis_H37Rv SAASGDGGNGGAGGAGGNGGDGDGFIGGSGGTGGTGGDAGVGGLANTGGT MUL_4367|M.ulcerans_Agy99 --AFGDG------------------VGGAGGIGGKGGNAAIGTIVING-- Mflv_5091|M.gilvum_PYR-GCK ---------------------------ANGSQGAAGKAGATGTTGATG-- Mvan_1264|M.vanbaalenii_PYR-1 ---------------------------ANGSQGAAGKAGATGTTGATG-- MSMEG_0868|M.smegmatis_MC2_155 ----GDGGAATTAG-------------ATGGAGGFSNIAAIHGAITDSTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M ---------------------------------------------GDGGA Mb3541|M.bovis_AF2122/97 ---------------------------------------------GDGGA Rv3508|M.tuberculosis_H37Rv AGNAGIGGAGGRGGDGGAGDSGALSQDGNGFAGGQGGQGGVGGNAGAGGI MUL_4367|M.ulcerans_Agy99 ------------------------------------------------GV Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------A Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------A MSMEG_0868|M.smegmatis_MC2_155 ISG--------------------------------------------HGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M AGAGGTGGNGGKGGNARLNGNG---------------------------- Mb3541|M.bovis_AF2122/97 GGTGGTGGTGGLGDPRVGGSGG---------------------------- Rv3508|M.tuberculosis_H37Rv NGAGGTGGTGGAGGDGQNGTTGVASEGGAGGQGGDGGQGGIGGAGGNAGF MUL_4367|M.ulcerans_Agy99 GGAGGSGGLGGATEDG---------------------------------- Mflv_5091|M.gilvum_PYR-GCK AGEDGDAGSGG--------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 AGDAGDPGSEA--------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 AGNGGNGGKGADGWVQAYDPAG---------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M ------DGGMGGQGGAAGTG---------------------GIGGAAGAG Mb3541|M.bovis_AF2122/97 ------DGGTGGSGGAAGNG---------------------GNGGNAGAG Rv3508|M.tuberculosis_H37Rv GAGVPGDGGIGGTGGAGGAGGAGADGDPSIDGGQGGAGGHGGQGGKGGLN MUL_4367|M.ulcerans_Agy99 ---------VGGVGCAGGAG---------------------GNGGRGDML Mflv_5091|M.gilvum_PYR-GCK ---------SGINGGAGGAG------------------------------ Mvan_1264|M.vanbaalenii_PYR-1 ---------VDINGGAGGAG------------------------------ MSMEG_0868|M.smegmatis_MC2_155 ----PVGSKIANSSAVAGNG---------------------GDGGVNGTG TH_3810|M.thermoresistible__bu ---------IMPSSRAASAR------------------------------ MAB_4284c|M.abscessus_ATCC_199 ----------DALGGSGSVG------------------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_4999|M.marinum_M GNG----------NGGAGGTGGVGGGG--GDGGTGGSSGKGGDGGTGGTG Mb3541|M.bovis_AF2122/97 GNG----------NGGTGGAGGIGGTG--GNGGDAEPGVPPGAGGAGGAG Rv3508|M.tuberculosis_H37Rv STGLASAASGDGGNGGAGGAGGNGGAG--GLGGGGGTGGTNGNGGLGGGG MUL_4367|M.ulcerans_Agy99 FT-----------VGGSGGTGGDGGGG--GSASGSGTGGSGGTGGVGGIG Mflv_5091|M.gilvum_PYR-GCK ---------------GAGGEGGEGGDG--GKGGAGAEGGAGGGGGAGGSG Mvan_1264|M.vanbaalenii_PYR-1 ---------------GAGGEGGEGGAG--GAGGDGSEGGAGGSGGAGGSG MSMEG_0868|M.smegmatis_MC2_155 --------------GASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNG TH_3810|M.thermoresistible__bu ------------------------------AGAACASSTSRSRRSFCCSR MAB_4284c|M.abscessus_ATCC_199 ---------------GSTAVGGGAHTSAINESMNSSINASHSSSMNESFG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------GGLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLG MMAR_4999|M.marinum_M AVGGMGGAGGSGTGTGTGGTGGDGGD---------------GGDGGDGGG Mb3541|M.bovis_AF2122/97 TTGGKGGTGGNGSGTGSGGTGGDGGT---------------GGGGGNGGT Rv3508|M.tuberculosis_H37Rv GNGGAGGAGGTPTGSGTEGTGGDGGDAGAGGNGGSATGVGNGGNGGDGGN MUL_4367|M.ulcerans_Agy99 GDGKLG------------------------------------GFGGDGGD Mflv_5091|M.gilvum_PYR-GCK AG----------------------------------------GAGGAGGS Mvan_1264|M.vanbaalenii_PYR-1 TG----------------------------------------GAGGAGGS MSMEG_0868|M.smegmatis_MC2_155 GDGSEP------------------------------------GPGGNGAG TH_3810|M.thermoresistible__bu A------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SS---------------------------------------MGSHGAAGT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GGHK---------------------------------------------- MMAR_4999|M.marinum_M GDGGAIPGTGGGDGGSGDTGNLPVGVTGGTGGTGGTAGTAGAGGLT Mb3541|M.bovis_AF2122/97 GWNGGKGDTGSG-GGAGDGGKAPAGGTGGAGGDGGAGGKGGSGGV- Rv3508|M.tuberculosis_H37Rv GGDGGNGAPGGFGGGAGAGGLGGSGAGGGTDGDDGNGGSPGTDGS- MUL_4367|M.ulcerans_Agy99 GGDGGFGVIGGQGGGGGFGGLGGTGAGG-APSDKGINGEPGNPG-- Mflv_5091|M.gilvum_PYR-GCK GGSGGSGGSGGSGGAAGDSDD------------------------- Mvan_1264|M.vanbaalenii_PYR-1 GGSGGSGGAGGSGGAAGDSD-------------------------- MSMEG_0868|M.smegmatis_MC2_155 GAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP- TH_3810|M.thermoresistible__bu ---------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GFEAQGHAQGHASETAHTTLPGAEHH-------------------- MLBr_01183|M.leprae_Br4923 ---------------------------------------------- MAV_4827|M.avium_104 ----------------------------------------------