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MSVDVSHRAPVAFQLATAATWPDPWPMYRALRDQDPVHHVIPAHQPDQDYYVLSRHADVWAAARDHQTFS SAQGLTVNYGDLEMIGLQDNPPMVMQDPPAHTEFRKLVSRGFTPRQVEAVEPKVRDFVVERIERLRAQGG GDIVTELFKPLPSMVVAHYLGVPEQDRTQFDGWTQAIVAANTAEGGIAGALATVGDAVGSMMAYFTSLIE RRRAKPEDDTISHLVAAGVGADGDIAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLTDN PELITDAVEELLRLTSPVQGLARTVTHDVTIGNVTIPAGRRALLLYGSANRDERQYGPDAGELDVRRCPR NILTFSHGAHHCLGAAAARMQSRVALTELLARCPDFEVDESRIVWSGGSYVRRPLSLPFEVRS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4184 | cyp130A4 | - | 100% (413) | cytochrome P450 130A4 Cyp130A4 |
| M. marinum M | MMAR_4833 | cyp123B1 | 2e-71 | 40.98% (388) | cytochrome P450 123B1 Cyp123B1 |
| M. marinum M | MMAR_4753 | cyp189A7 | 1e-62 | 37.37% (396) | cytochrome P450 189A7 Cyp189A7 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 1e-54 | 34.78% (391) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_2229 | - | 0.0 | 79.90% (413) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1256c | cyp130 | 0.0 | 86.53% (401) | cytochrome P450 130 CYP130 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-39 | 29.90% (408) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1406c | - | 1e-176 | 73.25% (415) | cytochrome P450 |
| M. avium 104 | MAV_1404 | - | 0.0 | 86.31% (409) | putative cytochrome P450 130 |
| M. smegmatis MC2 155 | MSMEG_5038 | - | 0.0 | 76.77% (409) | putative cytochrome P450 123 |
| M. thermoresistible (build 8) | TH_3609 | - | 1e-180 | 76.98% (404) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0324 | cyp189A7 | 9e-62 | 36.87% (396) | cytochrome P450 189A7 Cyp189A7 |
| M. vanbaalenii PYR-1 | Mvan_4465 | - | 0.0 | 80.54% (411) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4184|M.marinum_M --------------------------MSVDVSHRAPVAFQLATAATWPDP
Rv1256c|M.tuberculosis_H37Rv --------------------------MTSVMSH----EFQLATAETWPNP
MAV_1404|M.avium_104 ------------------------------MSHNVPVAFELPNADTWADP
Mflv_2229|M.gilvum_PYR-GCK --------------------------MTAVLSHGSPARFEPANASTWRDP
Mvan_4465|M.vanbaalenii_PYR-1 --------------------------MTAVLSHGSPVHFALADASTWADP
MSMEG_5038|M.smegmatis_MC2_155 --------------------------MGADLSHP-AVAFELANADTWADP
TH_3609|M.thermoresistible__bu ------------------------------VSQT-PVRFTLSTAATWSDP
MAB_1406c|M.abscessus_ATCC_199 --------------------------MSVDVSHTVAPRYVPGTADNWTNP
MUL_0324|M.ulcerans_Agy99 ----------------------------MTVTAASDVYFDPYDVELNADP
Mb0789c|M.bovis_AF2122/97 ---------------------------MTVRVGDPELVLDPYDYDFHEDP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:*
MMAR_4184|M.marinum_M WPMYRALRDQDPVHHVIPAHQPDQDYYVLSRHADVWAAARDHQTFSSAQG
Rv1256c|M.tuberculosis_H37Rv WPMYRALRDHDPVHHVVPPQRPEYDYYVLSRHADVWSAARDHQTFSSAQG
MAV_1404|M.avium_104 WPMYRALRDHDPVHHVVPPKRPEHDYYVLSRHADVWAAARDHETFSSAKG
Mflv_2229|M.gilvum_PYR-GCK WPMYRALRDHDPVHHVVPAD-PQHDYYVLSRHADIWAAARDHETFSSAQG
Mvan_4465|M.vanbaalenii_PYR-1 WPMYRALRDHDPVHHVVPEDRPNHDYYVLSRHADIWAAARDHQTFSSALG
MSMEG_5038|M.smegmatis_MC2_155 WDMYTALRDHDPVHHVVPPERPHHDYFVLSRHADIWAAARDHETYSSAQG
TH_3609|M.thermoresistible__bu WPMYAALRDHDPVHHVVPEHRPEHDYYVLSRHADVWRAARDHETFSSARG
MAB_1406c|M.abscessus_ATCC_199 WPMYAALRDHDPVHHVVPEYTPDQDYYVLTRHADVYEAARDWETFSSARG
MUL_0324|M.ulcerans_Agy99 YPMFRRLREEAPLYYN-----AQHGFYALSRFADVDRAIVDYQTFSSARG
Mb0789c|M.bovis_AF2122/97 YPYYRRLRDEAPLYRN-----EERNFWAVSRHHDVLQGFRDSTALSNAYG
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLP------GMPLTVFSSFSDCDEALRHPLSASDRLK
: : * : *: ..: . * . . : *.
MMAR_4184|M.marinum_M LTVNYGDLEMIG---LQDNPPMVMQDPPAHTEFRKLVSRGFTPRQVEAVE
Rv1256c|M.tuberculosis_H37Rv LTVNYGELEMIG---LHDTPPMVMQDPPVHTEFRKLVSRGFTPRQVETVE
MAV_1404|M.avium_104 LTVNYDDLELIG---LQDNPPFVMQDPPVHTEFRKLVSRGFTPRQVEAVE
Mflv_2229|M.gilvum_PYR-GCK LTVNYGELDLIG---LADNPPMVMQDPPGHTEFRRLVARGFTPRQVEAVE
Mvan_4465|M.vanbaalenii_PYR-1 LTVNYGELDLIG---LADNPPMVMQDPPVHTEFRKLVARGFTPRQVEAVE
MSMEG_5038|M.smegmatis_MC2_155 LTVNYGELELIG---LADNPPFVMQDPPTHTEFRKLVSRGFTPRQVEAVE
TH_3609|M.thermoresistible__bu LTVNYDELELIG---LADNPPFVMQDPPVHTEFRKLVSRGFTPRQVTAVE
MAB_1406c|M.abscessus_ATCC_199 LTVTYGDLEKTG---MGDNPPMVMQDPPTHTEFRKLVSRGFTPRQVTAVE
MUL_0324|M.ulcerans_Agy99 AILEFIKANIDI---PAG--VLVFEDPPVHDVHRKLLSRMFTPRKINDLE
Mb0789c|M.bovis_AF2122/97 VSLDPSSRTSEA---YRVMSMLAMDDP-AHLRMRTLVSKGFTPRRIRELE
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALE
: : : ** * * *::: *:*: : :*
MMAR_4184|M.marinum_M PKVRDFVVERIERLRAQGGGDIVTELFKPLPSMVVAHYLGVPEQDRTQFD
Rv1256c|M.tuberculosis_H37Rv PTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPEEDWTQFD
MAV_1404|M.avium_104 PKVRDFVVERIERLRAAGGGDIVAELFKPLPSMVVAHYLGVPEEDRAQFD
Mflv_2229|M.gilvum_PYR-GCK PKVREFVVERIERLRADGGGDIVAELFKPLPSMVVAHYLGVPDEDRGKFD
Mvan_4465|M.vanbaalenii_PYR-1 PKVHDFVVDRIEHLRANGGGDIVAELFKPLPSMVVAHYLGVPDEDRGKFD
MSMEG_5038|M.smegmatis_MC2_155 PQVREFVVERLERLRAEGGGDIVAELFKPLPSMVVAHYLGVPEADRAQFD
TH_3609|M.thermoresistible__bu PAVRRFVVERIERLRADGGGDIVAELFKPLPSMVVAHYLGVPESDRAQFD
MAB_1406c|M.abscessus_ATCC_199 PKVREFVVQRLERLKERGEGDIVVELFKPLPSMVVAHYLGVPEEDRTQFD
MUL_0324|M.ulcerans_Agy99 PKIREFCARSLDPLIGSGRFDFVADLGAQMPMRVIGMLLGVPEEDQEAAR
Mb0789c|M.bovis_AF2122/97 PQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIR
MLBr_02088|M.leprae_Br4923 GDIAALVDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFG
: : :: *.:.:: :. *: :*** *
MMAR_4184|M.marinum_M GWTQAIVAANT----AEGGIAGALATVGDAVGSMMAYFTSLIERRRAKPE
Rv1256c|M.tuberculosis_H37Rv GWTQAIVAANA----VDGATTGAL----DAVGSMMAYFTGLIERRRTEPA
MAV_1404|M.avium_104 GWTEAIVAANT----ADGGVAGALGSAGDAVTSMMAYFTGLIERRRTDPE
Mflv_2229|M.gilvum_PYR-GCK GWTDAIVAANT----TDGGIAGALGTLGDALGEMMGYFTALIERRRSEPA
Mvan_4465|M.vanbaalenii_PYR-1 GWTDAIVAANT----SAGGLGGALDTLGDALGEMMSYFTALIERRRTEPE
MSMEG_5038|M.smegmatis_MC2_155 GWTEAIVAANS----EAGSALGAG----DAVMSMTGYFAELIERRRREPG
TH_3609|M.thermoresistible__bu RWTDAIVAANT----GADGVMGAG----AAVGEMMAYFTELIEYRRREPA
MAB_1406c|M.abscessus_ATCC_199 AWTDGIVAAASG---GAIDIEAMQGEVAQTIGELMMYFTGLIERRRAEPE
MUL_0324|M.ulcerans_Agy99 DFATAQLRTEAG---KPMKASADG-------MVSGDFFAHYIDWRAEHPS
Mb0789c|M.bovis_AF2122/97 ALADAVLHRED-------GVADVPPPAMAASIELMRYYADLIAEFRRRPA
MLBr_02088|M.leprae_Br4923 RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPG
: : : : *
MMAR_4184|M.marinum_M DDTISHLVAAGVGADGDIAGTLS---ILAFTFTMVTGGNDTVTGMLGGSM
Rv1256c|M.tuberculosis_H37Rv DDAISHLVAAGVGADGDTAGTLS---ILAFTFTMVTGGNDTVTGMLGGSM
MAV_1404|M.avium_104 DDTISHLVSAGVGADGDIAGTLS---VLAFTFTMVTGGNDTTTGMLGGSM
Mflv_2229|M.gilvum_PYR-GCK DDTVSHLVAAGVGADGDISGVLS---ILAFTFTMVTGGNDTTTGMLGGSV
Mvan_4465|M.vanbaalenii_PYR-1 DDTISHLVAAGVGADGDISGVLS---ILAFTFTMVTGGNDTTTGMLGGSV
MSMEG_5038|M.smegmatis_MC2_155 DDTISHLVAAGA--DDEAVDVLS---ILAFTFTMVTGGNDTTTGMLGGAV
TH_3609|M.thermoresistible__bu DDTISHLVAAG-------VDPLP---VLAFTFTMVTGGNDTTTGMLGGTM
MAB_1406c|M.abscessus_ATCC_199 DDTVSHLVAAGVGADGDISGTLQ---ILGFAFTMVTGGNDTTTGMLGGAI
MUL_0324|M.ulcerans_Agy99 SDIMTELLNAEFEDETGTVRRLRRDELLTYVSVVSGAGNETTTRLIGWAG
Mb0789c|M.bovis_AF2122/97 NNLTSALLAAELD-----GDRLSDQEIMAFLFLMVIAGNETTTKLLANAV
MLBr_02088|M.leprae_Br4923 EDLISRLIELDES-----GDQLTEEEIIATCGLLLVAGHETTVNLIANAV
.: : *: * :: : .*::*.. ::. :
MMAR_4184|M.marinum_M PLLHRRPDQRRLLTDNPELITDAVEELLRLTSPVQGLARTVTHDVTIGNV
Rv1256c|M.tuberculosis_H37Rv PLLHRRPDQRRLLLDDPEGIPDAVEELLRLTSPVQGLARTTTRDVTIGDT
MAV_1404|M.avium_104 PLLHQRPDQRQRLVDEPELIPDAVEELLRLTSPVQGLARTTTRDVTIGRT
Mflv_2229|M.gilvum_PYR-GCK QLLHQRPDQRRLLADNPNLIPDAVDEFLRLTSPVQMLGRTVTRDVTLHDV
Mvan_4465|M.vanbaalenii_PYR-1 QLLHRRPDQRTMLAENPDLIPDAVDEFLRLTSPVQMLGRTVTHDVTIGDV
MSMEG_5038|M.smegmatis_MC2_155 QLLQQHPDQRRVLTDDPDLIPDAVDEFLRLTSPVQGLARTATRDVTIGDT
TH_3609|M.thermoresistible__bu QLLHRRPDQRRLLVERPELIADAVDEFLRLTSPVQGLARTSTRDVTIGDT
MAB_1406c|M.abscessus_ATCC_199 QLLHQNPAQRQKLIDDPSLIPGAVEEFLRLTSPVQGLARTATRDVIIGDT
MUL_0324|M.ulcerans_Agy99 KVLAEHPDQRRALVEDPSLIPQAVEELLRYEAPAPHVARYVTRDLRYYGQ
Mb0789c|M.bovis_AF2122/97 YWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDT
MLBr_02088|M.leprae_Br4923 LAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIGRVAAKDMTIGQT
..* * : . . *:* ** .. :.* ::*:
MMAR_4184|M.marinum_M TIPAGRRALLLYGSANRDERQYGPDAGELDVRRCPRNILTFSHGAHHCLG
Rv1256c|M.tuberculosis_H37Rv TIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPRNILTFSHGAHHCLG
MAV_1404|M.avium_104 TIPAGRRVLLLYGSANRDERQYGPDAGELDVARCPRNILTFSHGAHHCLG
Mflv_2229|M.gilvum_PYR-GCK TIPEGRRVMFLYGSGNRDERHFGDDAGELDVTRRPRNILTFSHGAHHCLG
Mvan_4465|M.vanbaalenii_PYR-1 TIPEGRRVMFLYGSGNRDERQYGDDAGELDVTRKPRNILTFSHGAHHCLG
MSMEG_5038|M.smegmatis_MC2_155 TIPAGRKVLLLYGSGNRDEREFGPDAAQLDVRRRPRNILTFSHGAHFCLG
TH_3609|M.thermoresistible__bu TIPAGRKVLLLYASANRDEREFGPDAAELDVTRRPRNILTFSHGAHFCLG
MAB_1406c|M.abscessus_ATCC_199 TIPAGRRALLLYGSANRDEREYGNDAAELDVLRKPRNILTFSHGNHHCLG
MUL_0324|M.ulcerans_Agy99 SVPEGSIMMMLIGAANRDHRQFRPDGDVFNIRREPHQHLTFSVGTHYCLG
Mb0789c|M.bovis_AF2122/97 TIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLG
MLBr_02088|M.leprae_Br4923 TLTEGDTMVLLLAAANRDPAVYSRP-DEFDPDRPSSRHLAFAVGSHFCLG
::. * ::* .:.*** : . . ::*. * *.***
MMAR_4184|M.marinum_M AAAARMQSRVALTELLARCPDFEVDESRIVWSGGSYVRRPLSLPFEVRS-
Rv1256c|M.tuberculosis_H37Rv AAAARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPFRVTS-
MAV_1404|M.avium_104 AAAARMQSRVALTELLARCPDFEVDESGIVWAGGNYVRRPLSVPIRVKS-
Mflv_2229|M.gilvum_PYR-GCK AAAARMQSRVALTELLTRIPNFEVDESGIVWAGGSYVRRPLSVPFTVTS-
Mvan_4465|M.vanbaalenii_PYR-1 AAAARMQSRVALTELLTRIPDFEVDESGIAWAGGSYVRRPVSVPFTVTH-
MSMEG_5038|M.smegmatis_MC2_155 AAAARMQSRVALTELLTRCPDFTVDLDAVVWAGGSYVRRPLSVPFRAGA-
TH_3609|M.thermoresistible__bu AAAARMQSRVALTELLVRCPEFSVDEDGITWADGGYVRRPLTLPVRIPGQ
MAB_1406c|M.abscessus_ATCC_199 AAAARMQSRIALEELLTRIPDFEVDLDGVTWADGSYVRRPLTVPIRVR--
MUL_0324|M.ulcerans_Agy99 SALARLEGRIALEDILKRFPEWDVDLGNAKLSPTSTVRGWESMPAVFD--
Mb0789c|M.bovis_AF2122/97 AHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR
MLBr_02088|M.leprae_Br4923 AALARLEATVTLSAISARFPQVQLAG-ELVYKPNVAMRGMSALPVQV---
: **:: ::* : * : : :* :*
MMAR_4184|M.marinum_M ----
Rv1256c|M.tuberculosis_H37Rv ----
MAV_1404|M.avium_104 ----
Mflv_2229|M.gilvum_PYR-GCK ----
Mvan_4465|M.vanbaalenii_PYR-1 ----
MSMEG_5038|M.smegmatis_MC2_155 ----
TH_3609|M.thermoresistible__bu APRR
MAB_1406c|M.abscessus_ATCC_199 ----
MUL_0324|M.ulcerans_Agy99 ----
Mb0789c|M.bovis_AF2122/97 ----
MLBr_02088|M.leprae_Br4923 ----