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MSFVAVAPDLLATATMDLDRIGNAINAGSTAAAASTTEVAAAAADEISTAVAELFGAYARGYQIIGAQAA MFHAEFVRALDIGAGAYWATEVANASPLQSLEQQLLAAINAPTQTLLGRPLIGNGADGAAGTGADGGAGG LLYGNGGAGGSGGTAHPTGGRGGNAGLFGSGGIGGSGAAGAAGGTGGNGGLLYGAGGNGGAGGNAVIPGG DGGMGGAGGAAGLIGQGGNGGVGGLGATGAAGVNPSPLPAGTPAAAGTPGGSDLGQPGAPGGPGDYGVST ATVGQPGGEGGAGGDGNYVGGVGGTGGAGGVGAVGGDGGRGGDSTTGTVAKLGVGGTGGTGGAGGAGAAG GNGGDGGSAIADSNEGGTGGTGGTGGTGGTGAVGGNGGTGGNGFVGGAGGSGGSGGVGAAGDGGGAGGVG GAGGHGGLLFGDGGAGGSGGGGAMGGAGAAGGQGGTGGTGGDSSAIDDRLAGNGGNGGTGGDGGAGGDGG NGGNGGAGGAGGLFGHTGASGAGGSAGTGGAGGNPGAGGDGGSAVIMPGISGADGRLGDAGADGVAGLSG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_4735 | - | - | 100% (560) | PE-PGRS family protein |
M. marinum M | MMAR_1161 | - | e-169 | 55.98% (602) | PE-PGRS family protein |
M. marinum M | MMAR_3816 | - | e-161 | 54.66% (580) | PE-PGRS family protein, PE_PGRS59 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3621c | PE_PGRS58 | 1e-165 | 54.41% (601) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-110 | 46.63% (549) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3590c | PE_PGRS58 | 1e-165 | 54.41% (601) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 7e-11 | 35.42% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 3e-47 | 34.40% (468) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 7e-27 | 39.90% (208) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-83 | 39.18% (559) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 6e-43 | 39.87% (306) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 1e-142 | 47.83% (644) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-108 | 46.19% (565) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mb3621c|M.bovis_AF2122/97 -------------------------------------------------- Rv3590c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4735|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3621c|M.bovis_AF2122/97 -------------------------------------------------- Rv3590c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4735|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3621c|M.bovis_AF2122/97 ------------------------------------MSFVIVAPEALMSV Rv3590c|M.tuberculosis_H37Rv ------------------------------------MSFVIVAPEALMSV MMAR_4735|M.marinum_M ------------------------------------MSFVAVAPDLLATA MUL_4367|M.ulcerans_Agy99 ------------------------------------MSFVSVGPGLLEAA Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------------------MNIVLGVSMAPSSIQMV Mb3621c|M.bovis_AF2122/97 AS------------------------------------EVAGIGSALNAA Rv3590c|M.tuberculosis_H37Rv AS------------------------------------EVAGIGSALNAA MMAR_4735|M.marinum_M TM------------------------------------DLDRIGNAINAG MUL_4367|M.ulcerans_Agy99 AR------------------------------------DLAGLGAGLREA Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VEAAS---------------------------------YVADPEAALANA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VLEG-------------------------------EYADGATVEEDAIDV Mb3621c|M.bovis_AF2122/97 N--------------------AAAAAPTTG----------VLAAAADEVS Rv3590c|M.tuberculosis_H37Rv N--------------------AAAAAPTTG----------VLAAAADEVS MMAR_4735|M.marinum_M S--------------------TAAAASTTE----------VAAAAADEIS MUL_4367|M.ulcerans_Agy99 N--------------------LAAAGATVG----------VLPAAGDEVS Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 G-------------------LSAVSAAQVG-----AVMPVVAESVASNYG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 TG--------------------ADDAATAS---------APDRVISAILG Mb3621c|M.bovis_AF2122/97 AA-----MAALFGAHAQEYQRLSAQAAGFHAQFVQALN----AGVNSYAS Rv3590c|M.tuberculosis_H37Rv AA-----MAALFGAHAQEYQRLSAQAAGFHAQFVQALN----AGVNSYAS MMAR_4735|M.marinum_M TA-----VAELFGAYARGYQIIGAQAAMFHAEFVRALD----IGAGAYWA MUL_4367|M.ulcerans_Agy99 AA-----IAELFGGFGREYQAMGARVALLHDDFVRALT----AGGSAYGQ Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 YQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSPRDNDFLSHND MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 TREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAA Mb3621c|M.bovis_AF2122/97 AEAANASPLQAVEQQVLGLIN--GPAQTLLG--RPLIGNGADGAPGT-GQ Rv3590c|M.tuberculosis_H37Rv AEAANASPLQAVEQQVLGLIN--GPAQTLLG--RPLIGNGADGAPGT-GQ MMAR_4735|M.marinum_M TEVANASPLQSLEQQLLAAIN--APTQTLLG--RPLIGNGADGAAGT-GA MUL_4367|M.ulcerans_Agy99 AEALNMWPLQELEQQALGVVN--APSMALFG--RPSIGNGVDGVAGT-GQ Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNG--GNGGVGVVGATGAVG--APGVAGATGA Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNG--GNGGVGIAGATGAVG--APGVAGATGA MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAG--GAGGVGADGTSAHVDGGTGGTGGTGGG TH_3810|M.thermoresistible__bu ----------------------------------------VDGDGGSGGR MAB_4284c|M.abscessus_ATCC_199 TDFASHNPIASGNQVMSPSGN--VDSFNRGPLLDLSFGDLQFGNRDTTAI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESY Mb3621c|M.bovis_AF2122/97 PGGPGGLLWGNGG-------NGGSGVAGVGGPGGSGG------------- Rv3590c|M.tuberculosis_H37Rv PGGPGGLLWGNGG-------NGGSGVAGVGGPGGSGG------------- MMAR_4735|M.marinum_M DGGAGGLLYGNGG-------AGGSGGT-AHPTGGRGG------------- MUL_4367|M.ulcerans_Agy99 AGGAGGILWGNGG-------NGGLGAA--GANGGAGG------------- Mflv_5091|M.gilvum_PYR-GCK TGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG------------- Mvan_1264|M.vanbaalenii_PYR-1 TGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG------------- MSMEG_0868|M.smegmatis_MC2_155 TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPN TH_3810|M.thermoresistible__bu TGLFSKLSRGGDG-----------------GDGGLGG------------- MAB_4284c|M.abscessus_ATCC_199 GDGAVAVGGSNSGP-----IASGQGSTAVNGDVRDSN------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GDAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSV Mb3621c|M.bovis_AF2122/97 ----AAGLFGHGGNGGAGGS-NAAGAGGVGGAGGA--------------- Rv3590c|M.tuberculosis_H37Rv ----AAGLFGHGGNGGAGGS-NAAGAGGVGGAGGA--------------- MMAR_4735|M.marinum_M ----NAGLFGSGGIGGSG---AAGAAGGTGGNG----------------- MUL_4367|M.ulcerans_Agy99 ----SAGLIGTGGVGGAGGVGAAGMTGGSGGAGGGG-------------- Mflv_5091|M.gilvum_PYR-GCK -AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG-------------- Mvan_1264|M.vanbaalenii_PYR-1 -AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG-------------- MSMEG_0868|M.smegmatis_MC2_155 VTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVD TH_3810|M.thermoresistible__bu -------NGGHGGGTGIISLLSLAGNGGNGGNGYR--------------- MAB_4284c|M.abscessus_ATCC_199 --IINADHGSNVGVDQSQTRVGGDYTNVSGHGSADIDKS----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AEEPETALARGAALAAANAPLFASSTAALAYAQDPG-------------- Mb3621c|M.bovis_AF2122/97 GWLVGNGGAGGFG------------------------------------- Rv3590c|M.tuberculosis_H37Rv GWLVGNGGAGGFG------------------------------------- MMAR_4735|M.marinum_M GLLYGAG------------------------------------------- MUL_4367|M.ulcerans_Agy99 GWLWGAGGSGGAAGAGGSGGSGGWLWGNAGQTAGAGVGGAGGAGGAGDAG Mflv_5091|M.gilvum_PYR-GCK --AVGAAGAAG--------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 --AIGTAGVAG--------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 GHAIGGNGGNGGN------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VTVVDDHSQRNTTNIN---------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---TGAVDQYSLP------------------------------------- Mb3621c|M.bovis_AF2122/97 ------------------------------GVGTTVSGNGGAGGAAGAFG Rv3590c|M.tuberculosis_H37Rv ------------------------------GVGTTVSGNGGAGGAAGAFG MMAR_4735|M.marinum_M -------------------------------------GNGGAG------- MUL_4367|M.ulcerans_Agy99 DQGVSGVAPGEAGAVGFAGGAGGAGGAGGNGVGGGVNGAGGAGGAGGVGG Mflv_5091|M.gilvum_PYR-GCK ----------------------------------TVGTAGATGGTG---- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------AAGTAGATGGTG---- MSMEG_0868|M.smegmatis_MC2_155 ------------------------------GSTTAAGGNGGTGGTGRVIA TH_3810|M.thermoresistible__bu ----------------------------------TTDNNALDGGHG---- MAB_4284c|M.abscessus_ATCC_199 -----------------------------DSFNTDRSTNIGSGNTTNTEI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------------------------DYLYVPVDPEPGDDELAYSAV Mb3621c|M.bovis_AF2122/97 NGGV----------------GGAGGAAVIGGLPGNGGAG----------- Rv3590c|M.tuberculosis_H37Rv NGGV----------------GGAGGAAVIGGLPGNGGAG----------- MMAR_4735|M.marinum_M -----------------------GNAVIPGGDGGMGGAG----------- MUL_4367|M.ulcerans_Agy99 GGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAAGTGGTG----------- Mflv_5091|M.gilvum_PYR-GCK -------------------TGANGGAGGVGGVGGTGAAG----------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------VGGNGGAGQAGGIGGTGAAG----------- MSMEG_0868|M.smegmatis_MC2_155 EGTGSTAEGTA--------TGGDGGHSTGTGIGGNGGIGSVYAYGNNGAV TH_3810|M.thermoresistible__bu ---------------------GNGGNVGFFSLFNLGGAG----------- MAB_4284c|M.abscessus_ATCC_199 G------------------SHNQANIGTSTSAGGSAAVG----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GEEDAESPTVVIEKLFLPEDSEPRRRPVLLVGSGLAVVG----------- Mb3621c|M.bovis_AF2122/97 -----GNAGLIGA-GGDGGVGGVG-------------------------- Rv3590c|M.tuberculosis_H37Rv -----GNAGLIGA-GGDGGVGGVG-------------------------- MMAR_4735|M.marinum_M -----GAAGLIGQ-GGNGGVGGLG-------------------------- MUL_4367|M.ulcerans_Agy99 -----GAAGVAGT-GGDGGDGGAGGAGSDASLAGQAGFAGGSGGAGGVGG Mflv_5091|M.gilvum_PYR-GCK ---AAGGAGGLGETGTTGGAGGVGGQ----------------------GT Mvan_1264|M.vanbaalenii_PYR-1 ---AAGQAGTAGETGVTGGVGGIGGQ----------------------GT MSMEG_0868|M.smegmatis_MC2_155 SGTATGGRGGDGIDGGTGGAGGMGEIYS--------------------GA TH_3810|M.thermoresistible__bu ---------------GWGGSGVDG-------------------------- MAB_4284c|M.abscessus_ATCC_199 -----GNAGLAGNAGLAGNAGLAG-------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----ISAVLALEIALAIGIRTTGTVALQP-----------------TPN Mb3621c|M.bovis_AF2122/97 APGTNGMNPPPNQT-SQAANGSPGANN----GAGSG-------------- Rv3590c|M.tuberculosis_H37Rv APGTNGMNPPPNQT-SQAANGSPGANN----GAGSG-------------- MMAR_4735|M.marinum_M ATGAAGVNPSPLPAGTPAAAGTPGGSD----LGQPG-------------- MUL_4367|M.ulcerans_Agy99 SAGAGGVNGSGGDGGAGAAGGAGGASAT---VAGSG-------------- Mflv_5091|M.gilvum_PYR-GCK AGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG-------------L Mvan_1264|M.vanbaalenii_PYR-1 EGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG-------------L MSMEG_0868|M.smegmatis_MC2_155 DGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTAKAG TH_3810|M.thermoresistible__bu -VDVVGGNPDGGTPGAHGESHTPGVYTD---------------------- MAB_4284c|M.abscessus_ATCC_199 NAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG-------------- MLBr_01183|M.leprae_Br4923 MPLFLNAEPQALTAAANTLEGLSAAT------------------------ MAV_4827|M.avium_104 QHLIVPTEQAPAPPPVQASAPQPKISVPEPVAAPKP-------------L Mb3621c|M.bovis_AF2122/97 --GAGLPGNPGAVPG-----------------------------RAGGAG Rv3590c|M.tuberculosis_H37Rv --GAGLPGNPGAVPG-----------------------------RAGGAG MMAR_4735|M.marinum_M --APGGPGDYGVSTA-----------------------------TVGQPG MUL_4367|M.ulcerans_Agy99 --GVGGDGGAGGAAGGGVGAASLGGDGGHAGAGGAGGEGLSGGFNTGAAG Mflv_5091|M.gilvum_PYR-GCK QGGKGGDGGAGGKGGDADSMGS-----------------------AGATG Mvan_1264|M.vanbaalenii_PYR-1 QGGQGGDGGTGGTGGDATSMGE-----------------------AGATG MSMEG_0868|M.smegmatis_MC2_155 HGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGG-----AASANG TH_3810|M.thermoresistible__bu --RQGEDGEDGTGTG------------------------------IGGRG MAB_4284c|M.abscessus_ATCC_199 --NAGLAGNAGLAGNAG----------------------------LAGNA MLBr_01183|M.leprae_Br4923 ---VASNAAAAQLTT--------------------------------EIA MAV_4827|M.avium_104 SPPVAAPLPAAPPPAAP---------------------------PLPEAP . . Mb3621c|M.bovis_AF2122/97 GLGGSGSDTSEGPVTG-----------------GNGGNGGD--------- Rv3590c|M.tuberculosis_H37Rv GLGGSGSDTSEGPVTG-----------------GNGGNGGD--------- MMAR_4735|M.marinum_M GEGGAGGD---GNYVG-----------------GVGGTGGA--------- MUL_4367|M.ulcerans_Agy99 GIGGAGGAGGTGGDSG-----------------GVGGVNGD--------- Mflv_5091|M.gilvum_PYR-GCK GKGGNGGNGGRGGLFG---------------KGGNAGNGAD--------- Mvan_1264|M.vanbaalenii_PYR-1 GKGGNGGNGGRGSLFG---------------RGGNAGNGGN--------- MSMEG_0868|M.smegmatis_MC2_155 AVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN TH_3810|M.thermoresistible__bu GNGGSSSGTHPMAEDG------------------EHVKALD--------- MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAGLAG------------------NAGLAGN--------- MLBr_01183|M.leprae_Br4923 PPAADDVSILLAHFFS---------------------------------- MAV_4827|M.avium_104 PIPAAPPVVPVPVVVP------------------PVPVPVP--------- . Mb3621c|M.bovis_AF2122/97 -------------GGPGAPGGNGAPGGIGVN-TGTGWA------------ Rv3590c|M.tuberculosis_H37Rv -------------GGPGAPGGNGAPGGIGVN-TGTGWA------------ MMAR_4735|M.marinum_M -------------GGVGAVGGDGGRGGDSTTGTVAKLG------------ MUL_4367|M.ulcerans_Agy99 -------------GGAGGGGGRGGDGGSSTSTSGVGGAGGA-GGNGGNAG Mflv_5091|M.gilvum_PYR-GCK -------------GGTGGAGGAGGTGG-TGGAGGTGG------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------GGTGGNGGNGGTGG-TGGNGGTGG------------- MSMEG_0868|M.smegmatis_MC2_155 GPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHST TH_3810|M.thermoresistible__bu -------------GRPGLDGGNGSHGG----------------------- MAB_4284c|M.abscessus_ATCC_199 -------------AGLAGNAGLAGNAGLAGNAGLAGNAG----------- MLBr_01183|M.leprae_Br4923 --------------GHGRQYQAHASQG----------------------- MAV_4827|M.avium_104 -------------VRIPVPDPVSPPQLLAPPRLSVPQPVQP--------- Mb3621c|M.bovis_AF2122/97 ----YGGNGGNGGDGGAG----------------ARGGDGGNGGNGLALN Rv3590c|M.tuberculosis_H37Rv ----YGGNGGNGGDGGAG----------------ARGGDGGNGGNGLALN MMAR_4735|M.marinum_M ----VGGTGGTGGAGGAG----------------AAGGNGGDGGSAIADS MUL_4367|M.ulcerans_Agy99 FGVSAGGTGGSAGDGGAGGGAGGVDGVGGASGNGGAAGAGGAGGSGIGAG Mflv_5091|M.gilvum_PYR-GCK ----TGGTGGIGGAGSTGGTGG----------TGGTGGTGGTGGTG-GTG Mvan_1264|M.vanbaalenii_PYR-1 ----TGGTGGIGGAGSTGGTGG----------TGGTGGTGGTGGTG-GTG MSMEG_0868|M.smegmatis_MC2_155 GQTDTGGNGGRGGDGGTFVNAG----------ANGNGGAGGAGGVSEGEG TH_3810|M.thermoresistible__bu ----NGGHGGRGGFLGIG----------------GSGGWGGHGGNGGDTD MAB_4284c|M.abscessus_ATCC_199 ----LAGNAAVAGNAAVAG--------------NAAVAGNAAVGGVLNTG MLBr_01183|M.leprae_Br4923 ----ATNHQDLIQSLLTS-----------------SSAYAGT-----ETA MAV_4827|M.avium_104 ----PVRVPQPPSPPQVGG---------------TVPQSPPQHQTPPGEG Mb3621c|M.bovis_AF2122/97 GGNGIGGNGGAG---------------GRGGTG----AAGGNGGIGG-GA Rv3590c|M.tuberculosis_H37Rv GGNGIGGNGGAG---------------GRGGTG----AAGGNGGIGG-GA MMAR_4735|M.marinum_M NEGGTGGTGGTG---------------GTGGTG----AVGGNGGTGGNGF MUL_4367|M.ulcerans_Agy99 IDGGAGGAGGTGGAAGFPGGGGTTGAWGTGGAG----GAGGAGGAGDHGG Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGKGGTGGTG---------GAGGTG----GDGGTGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGKGGTGGTG---------GDGGTG----GTGGTGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 GTGGHGGDGGRGGDGALG---------GNGGTGGVGLGNGGKGGNGGNGG TH_3810|M.thermoresistible__bu ADGGNGGDGGNG---------------GSAGRG-------GTGGLRG--- MAB_4284c|M.abscessus_ATCC_199 VSGAIGGSSHVG---------------GAINES-----LGGSGSVGGSTA MLBr_01183|M.leprae_Br4923 NHDSL--------------------------------------------- MAV_4827|M.avium_104 TPPKPDGPGNYGG--------------GHVPTP----GAGGSGGSGGGHV Mb3621c|M.bovis_AF2122/97 TGTLT--------------------------FFGSGGDGGPGGAG----- Rv3590c|M.tuberculosis_H37Rv TGTLT--------------------------FFGSGGDGGPGGAG----- MMAR_4735|M.marinum_M VG-------------------------------GAGGSGGSGGVG----- MUL_4367|M.ulcerans_Agy99 VGVNPGDSGTAGWAGGAGGAGGAGGSAAFNGVNGAGGAGGNGGAGGGGGA Mflv_5091|M.gilvum_PYR-GCK TG-------------------------------GTGGTGGTGGAG----- Mvan_1264|M.vanbaalenii_PYR-1 TG-------------------------------GTGGTGGTGGAG----- MSMEG_0868|M.smegmatis_MC2_155 NGGTYVDPS----------------------HTGAGGNGGNGGAGR---- TH_3810|M.thermoresistible__bu ---------------------------------VFGINGGNGRAG----- MAB_4284c|M.abscessus_ATCC_199 VG-------------------------------GGAHTGVGGGVS----- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PTP------------------------------GAGGSGGSGGGHVP--- Mb3621c|M.bovis_AF2122/97 ----------------------------------------ANTAGTGGVG Rv3590c|M.tuberculosis_H37Rv ----------------------------------------ANTAGTGGVG MMAR_4735|M.marinum_M ----------------------------------------AAGDG-GGAG MUL_4367|M.ulcerans_Agy99 GASGIGAGVAGGDGGTGGTGGAAGTGGAAGTGGTGGAAGAAGSAGDGGAG Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------DGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------DGLGGTG MSMEG_0868|M.smegmatis_MC2_155 ---------------------------------IRVNNGTATGTATGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------TGVGVGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3621c|M.bovis_AF2122/97 GVGGAG---GQGGLLFGD--------------------GGNGGAGG-AGG Rv3590c|M.tuberculosis_H37Rv GVGGAG---GQGGLLFGD--------------------GGNGGAGG-AGG MMAR_4735|M.marinum_M GVGGAG---GHGGLLFGD--------------------GGAGGSGG-GGA MUL_4367|M.ulcerans_Agy99 GAGGAGD-DGSAGVVSGDPG----------------TAGKAGGAGG-AGG Mflv_5091|M.gilvum_PYR-GCK GTGG----TGGQGGQGGQGG-----------------TGGTGGQGG-LGG Mvan_1264|M.vanbaalenii_PYR-1 GTGG----TGGFGGQGGQGG-----------------TGGTGGQGG-LGG MSMEG_0868|M.smegmatis_MC2_155 GNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGGTLGA TH_3810|M.thermoresistible__bu ----------------------------------------LGGRGX---- MAB_4284c|M.abscessus_ATCC_199 HVGG-----GISESLGGSGS-----------------VGGSTAVGG--GA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------TPGTGGPGG---- Mb3621c|M.bovis_AF2122/97 IGGTG-----------------------ASGGAGGKGGSG---------L Rv3590c|M.tuberculosis_H37Rv IGGTG-----------------------ASGGAGGKGGSG---------L MMAR_4735|M.marinum_M MGGAG-----------------------AAGGQGGTGGTGGDSSAIDDRL MUL_4367|M.ulcerans_Agy99 VGGNG-----------------------VAGGVNGSGGAGGAGGAGGTGG Mflv_5091|M.gilvum_PYR-GCK GGGTG-----------------------GQGGTGGTGGQGGTGGTGGTGG Mvan_1264|M.vanbaalenii_PYR-1 VGGTG-----------------------GTGGTGGTGGQGGTGGTGGTGG MSMEG_0868|M.smegmatis_MC2_155 TNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQGTIEA TH_3810|M.thermoresistible__bu -XXXG-------------------------GGVG---------------- MAB_4284c|M.abscessus_ATCC_199 HTGVG-------------------------GGVSTGVGVGSHVGGGISES MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 TGGSG-------------------------GGHVPTPGAGTP-------- Mb3621c|M.bovis_AF2122/97 VG----------GDGGNGGAGGAGGNGGKGG---------AGGAGGGAGM Rv3590c|M.tuberculosis_H37Rv VG----------GDGGNGGAGGAGGNGGKGG---------AGGAGGGAGM MMAR_4735|M.marinum_M AGNG--------GNGGTGGDGGAGGDGGNGG---------NGGAGGAGGL MUL_4367|M.ulcerans_Agy99 AGASGVPASVDGGDGGAGGAGGAAGTGGSGGSAGNTGAGGAGGAGGAGGS Mflv_5091|M.gilvum_PYR-GCK TG----------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGG Mvan_1264|M.vanbaalenii_PYR-1 TG----------GTGGAGGDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGG MSMEG_0868|M.smegmatis_MC2_155 NGPSAVASGI--GAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSATGT TH_3810|M.thermoresistible__bu -------------AAVRSGNGVFSGGGGTPS----------AGFGVPTTI MAB_4284c|M.abscessus_ATCC_199 LG----------GSGSVGGSTAVGGGAHTGVG---------GGVNTGVGV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------GGSGGGHLPFPGAGSTPG------------GSGGGHL Mb3621c|M.bovis_AF2122/97 FSQPGVHGAGGTGGQG--------------------GAGGAGGAGGAAGA Rv3590c|M.tuberculosis_H37Rv FSQPGVHGAGGTGGQG--------------------GAGGAGGAGGAAGA MMAR_4735|M.marinum_M FGHTGASGAGGSAGTG--------------------GAGGNPGAGGDGGS MUL_4367|M.ulcerans_Agy99 AASTGVNGDGGAGGAGGVGG----LGGDSAATAGGGGAGGDGGKGGAGGA Mflv_5091|M.gilvum_PYR-GCK AGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQGAT Mvan_1264|M.vanbaalenii_PYR-1 AGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQGAT MSMEG_0868|M.smegmatis_MC2_155 ATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEASN TH_3810|M.thermoresistible__bu QFPAGSCTSRAVSREG----------------------IMPSSRAASARA MAB_4284c|M.abscessus_ATCC_199 GSHVGGGISESLGGSG--------------------SVGGSTAVGGGAHT MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PTPGAGTPGGGLGGFGG-----------------GHAPAPGGGLGGGGGH Mb3621c|M.bovis_AF2122/97 GTVVAGN-------PGDPG-GFGAAGADGLPG------------------ Rv3590c|M.tuberculosis_H37Rv GTVVAGN-------PGDPG-GFGAAGADGLPG------------------ MMAR_4735|M.marinum_M AVIMPGI-------SGADG-RLGDAGADGVAGLSG--------------- MUL_4367|M.ulcerans_Agy99 GVNGVGGGDGGKGGTGGAG-GAGGAGSDGIIPSNGGLGGNGGNGGNGGQA Mflv_5091|M.gilvum_PYR-GCK GAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG------ Mvan_1264|M.vanbaalenii_PYR-1 GAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG------ MSMEG_0868|M.smegmatis_MC2_155 GGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSNIA TH_3810|M.thermoresistible__bu GAACASS-------TSRSRRSFCCSRA----------------------- MAB_4284c|M.abscessus_ATCC_199 SAINDALG-----GSGSVGGSTAVGGGAHTSAINESMNSS---------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 APAPGGG-------LGGFGGGHSGGGLGGLGGGHK--------------- Mb3621c|M.bovis_AF2122/97 -------------------------------------------------- Rv3590c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4735|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 FGDGVGGAGGIGGKGGNAAIGTIVINGGVGGAGGSGGLGGATEDGVGGVG Mflv_5091|M.gilvum_PYR-GCK ------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG------- Mvan_1264|M.vanbaalenii_PYR-1 ------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG------- MSMEG_0868|M.smegmatis_MC2_155 AIHGA-ITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSS TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------INASHSSSMNESFGSSMGSHGAAGTGFEAQG------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3621c|M.bovis_AF2122/97 -------------------------------------------------- Rv3590c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4735|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 CAGGAGGNGGRGDMLFTVGGSGGTGGDGGGGGSASGSGTGGSGGTGGVGG Mflv_5091|M.gilvum_PYR-GCK -AAGEDGDAGSGGSG-INGGAGGAGG------------AGGEGGEGGDGG Mvan_1264|M.vanbaalenii_PYR-1 -AAGDAGDPGSEAVD-INGGAGGAGG------------AGGEGGEGGAGG MSMEG_0868|M.smegmatis_MC2_155 AVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKS-GGQTADGEHNTGGNGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---HAQGHASETAHTTLPGAEHH--------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3621c|M.bovis_AF2122/97 -------------------------------------------------- Rv3590c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4735|M.marinum_M -------------------------------------------------- MUL_4367|M.ulcerans_Agy99 IGGDGKLGGFGGDGGDGGDGGFGVIGGQGGGGGFGGLGGTG-AGGAPSDK Mflv_5091|M.gilvum_PYR-GCK KGGAGAE--------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSG Mvan_1264|M.vanbaalenii_PYR-1 AGGDGSE--------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAG MSMEG_0868|M.smegmatis_MC2_155 NGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb3621c|M.bovis_AF2122/97 ----------- Rv3590c|M.tuberculosis_H37Rv ----------- MMAR_4735|M.marinum_M ----------- MUL_4367|M.ulcerans_Agy99 GINGEPGNPG- Mflv_5091|M.gilvum_PYR-GCK GSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 GSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 GTAGTTGANNP TH_3810|M.thermoresistible__bu ----------- MAB_4284c|M.abscessus_ATCC_199 ----------- MLBr_01183|M.leprae_Br4923 ----------- MAV_4827|M.avium_104 -----------