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MTEEMDRAYLQRPVGDLAPLPAERSLAVLIVIGNGHDPVQSCLHSVAEQLPGLPVYVYDNSGQGYPGRQE LAAGHPAVHWISGPADVGFAAACNALAQRSPGDSDLLLLKADARLRGPLTRTRQLLRQPGVAAVSPLVRD EAAPDRPPWDIATQRLTLVRGVVEATGLSSWLRATRISPLYPQRPRESQSVSGYLKATCLAISRAAWNAI GGFDEEYLNHGGPADWQARARAAGWRVLLADELGAQQGGAPPTGAETGPTVTAGERRRTRDVIRANDALL LEHQCSVHHADAYLATTKVLQRLRRAQRRAIRNTGAGKRRPAIVIATNRLVYGGAERQKALLAAELDRRG YPVTIVCVQRFGPLIKEIPDTVRVVRQPWWAPIVDVGPGPAVLISGDTNTETGFATLWRAAGRRRRWLVA AHIPPLEVGPIYSGPLTAAMRRADGFIVLAQRHWDMLTPYHRLGGPRFVAPNGVAVTDRPAGRSRPAGAP PHLVMLSRIVEHKNPHLLIEALSGITELPWTLSIFGDGPDRERLQARTPERLRDRVHWRGWSPGPGPALA DADLLCVPSRSEAFPLVILEAMARAVPVAASAICAVPEMLDFGGAGFVVEPVTVSAWRERLAQILADPGE LPAVGQRGFARMRKHYTVAAMTDAYLDAIHAVL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4505 | - | - | 100% (663) | glycosyltransferase |
| M. marinum M | MMAR_4514 | - | 7e-10 | 27.06% (218) | glycosyl transferase |
| M. marinum M | MMAR_1276 | wbbL1 | 7e-10 | 29.44% (197) | dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3- |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3293c | wbbL1 | 1e-10 | 26.72% (232) | dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol |
| M. gilvum PYR-GCK | Mflv_1501 | - | 1e-09 | 26.78% (183) | glycosyl transferase, group 1 |
| M. tuberculosis H37Rv | Rv3265c | wbbL1 | 1e-10 | 26.72% (232) | dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol |
| M. leprae Br4923 | MLBr_00752 | wbbL | 4e-09 | 32.11% (109) | putative dTDP-rhamnosyl transferase |
| M. abscessus ATCC 19977 | MAB_3612c | - | 7e-13 | 30.09% (226) | putative dTDP-rhamnosyltransferase |
| M. avium 104 | MAV_4230 | - | 3e-11 | 28.57% (217) | dTDP-RhA:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl |
| M. smegmatis MC2 155 | MSMEG_1826 | - | 2e-12 | 26.87% (227) | dTDP-RhA:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl |
| M. thermoresistible (build 8) | TH_0780 | wbbL | 5e-09 | 25.38% (197) | PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL POLYPRENOL, |
| M. ulcerans Agy99 | MUL_4676 | - | 0.0 | 96.53% (663) | glycosyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5245 | - | 4e-09 | 26.92% (234) | glycosyl transferase, group 1 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4505|M.marinum_M MTEEMDRAYLQRPVGDLAPLPAERSLAVLIVIGNGHDPVQSCLHSVAEQL
MUL_4676|M.ulcerans_Agy99 MTDEMDRAYLRRPVGDPAPLPADRSLAVLIVIENGHDPVQSCLHSVAEQL
Mb3293c|M.bovis_AF2122/97 ---------------------------MVAVTYSPGPHLERFLASLSLAT
Rv3265c|M.tuberculosis_H37Rv ---------------------------MVAVTYSPGPHLERFLASLSLAT
MLBr_00752|M.leprae_Br4923 ---------------------MTDVLPVVAVTYSPGPHLERFLASLALAT
MAV_4230|M.avium_104 ------------------------MLPVVTVTYSPGPHLERFLASLSLAT
MSMEG_1826|M.smegmatis_MC2_155 --------------------------MVVTVTYSPGPHLDRFLSSLSLAT
TH_0780|M.thermoresistible__bu ---------------------VSDHLVVVTVTYSPGPHLERFLASLEHAT
MAB_3612c|M.abscessus_ATCC_199 ----------MLDPHRVSDSPAIGQVAVVTVTYSPGEHLHRFLRTLRHAT
Mflv_1501|M.gilvum_PYR-GCK ----------------------MNRRHVTYLVSRFPVTSETFIVRELEAL
Mvan_5245|M.vanbaalenii_PYR-1 ----------------------MSRRDVVYLVSRFPVTSETFIVREIEAL
: : . :
MMAR_4505|M.marinum_M PGLPVYVYDNSGQGYPGRQELAAGHPAVHWISGPADVGFAAACN-ALAQR
MUL_4676|M.ulcerans_Agy99 PGLPVYVYDNNAQGYPGRQELAAGHPAVHWISGPADVGFAAACN-ALARQ
Mb3293c|M.bovis_AF2122/97 ERPVSVLLADNGSTDGTPQAAVQRYPNVRLLPTGANLGYGTAVNRTIAQL
Rv3265c|M.tuberculosis_H37Rv ERPVSVLLADNGSTDGTPQAAVQRYPNVRLLPTGANLGYGTAVNRTIAQL
MLBr_00752|M.leprae_Br4923 DRPVSVVLADNGSTDGTPQVAVERYVNVRLFETGANLGYGTAANLAIAQF
MAV_4230|M.avium_104 EREVCVLLADNGSTDGTPQAAVERYPNVRLFHTGANLGYGTAVNRAVAQL
MSMEG_1826|M.smegmatis_MC2_155 DRPVTVIMADNGSTDGTPEEAEQRYPNVRLLRTGANLGYGSAVNRAVAQL
TH_0780|M.thermoresistible__bu ERPVTVIMADNGSTDGAPEEALERYPNVRLMRTGANLGYGTAINRAVAEH
MAB_3612c|M.abscessus_ATCC_199 DLPLRVILADNGSTDGAPEAAAEE-PDVELLRTGGNVGYGKAANLGVAQV
Mflv_1501|M.gilvum_PYR-GCK DRSGEFELEIR-SLFPSPDRAVHEIARRWNEHLVRPSAFDAAAGVTWALL
Mvan_5245|M.vanbaalenii_PYR-1 DRSGKFHVEIR-SLFPSPDEPVHDIARRWSRHLVRPTARDAATGLAWALL
. : . * . *
MMAR_4505|M.marinum_M SPGDS--------DLLLLKADARLRGP---LTRTRQLLRQPGVAAVSPLV
MUL_4676|M.ulcerans_Agy99 SPGDS--------DLLLLKADARLRGP---LTRTRQLLRQPGVAAVSPLV
Mb3293c|M.bovis_AF2122/97 GEMAGDAGEPWVDDWVIVANPDVQWGPGSIDALLDAASRWPRAGALGPLI
Rv3265c|M.tuberculosis_H37Rv GEMAGDAGEPWVDDWVIVANPDVQWGPGSIDALLDAASRWPRAGALGPLI
MLBr_00752|M.leprae_Br4923 FEEGGATGQPWVDDWVIVANPDVQWGPGSIDALLDAAARWPRAGALGPLI
MAV_4230|M.avium_104 DR-GG--------EWVIVANPDVQWGPGSIDALLDAAARWPRAGALGPLV
MSMEG_1826|M.smegmatis_MC2_155 TAGEG-------TDFLVVANPDVQWGPKAIDLLLEASDRWPHAGAFGPLI
TH_0780|M.thermoresistible__bu LADTDP------SDFFVVANPDVQWGPNSIDNLLAAAARWPRAAALGPLI
MAB_3612c|M.abscessus_ATCC_199 DP---------AAEWVVIANPDVQWGPGSIDAMLEVAQRWPAAGAVGPLI
Mflv_1501|M.gilvum_PYR-GCK TRPIALMT-----ILANVVAGYRRRLPLLVRALMTVPLACAHARDLARRA
Mvan_5245|M.vanbaalenii_PYR-1 TRPIAVMS-----VLATVTSGYLRRPPLLVRALTTVPIACAHARDLARRG
: * . . ..
MMAR_4505|M.marinum_M RDEAAPDRPPWDIATQRLTLVRGVVEATGLSSWLRATRISPLYPQR-PRE
MUL_4676|M.ulcerans_Agy99 RDEAAPDRPPWDIATQRLTLVRGVVEATGLSSSLRATPISPLYPQR-PRE
Mb3293c|M.bovis_AF2122/97 RD---PDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTTAYRQER-LEP
Rv3265c|M.tuberculosis_H37Rv RD---PDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTTAYRQER-LEP
MLBr_00752|M.leprae_Br4923 RD---PDGSVYPSARHLPSLVRGGMHAVLGPVWPRNPWTAAYRQER-LEL
MAV_4230|M.avium_104 RD---PDGSVYPSARHLPSLVRGGMHAVVGPFWKNNPWSTAYRQER-LEP
MSMEG_1826|M.smegmatis_MC2_155 RD---PDGAIYPSARHQPSLLRGGLHAVVGPFWKNNPWTAAYRQDR-QEP
TH_0780|M.thermoresistible__bu RD---ADGSVYPSAREQPSLIRGGMHAVIGPLWPGNPWTAAYRQDR-MEP
MAB_3612c|M.abscessus_ATCC_199 RE---PDGTVYPSARVVPTLTGGALHALLGSVWSTNPWTAAYRQDR-MEP
Mflv_1501|M.gilvum_PYR-GCK QP-----CHVHAHYATYPALAAWVCHRLAGTSYSFTVHAHDLYVDTSMLD
Mvan_5245|M.vanbaalenii_PYR-1 RP-----CHVHAHYATYPALAAWVCRRLAGISYSFTVHAHDLYVDMSMLD
: :* . :
MMAR_4505|M.marinum_M SQSVSGYLKATCLAISRAAWNAIGGFDEEYLNHGGPADWQ-----ARARA
MUL_4676|M.ulcerans_Agy99 SQSFSGYLKATCLAISRAAWNAVGGFDEEYFSHGAPADWQ-----ARARA
Mb3293c|M.bovis_AF2122/97 SERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLG-----DRLGK
Rv3265c|M.tuberculosis_H37Rv SERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLG-----DRLGK
MLBr_00752|M.leprae_Br4923 TERPVGWLSGSCLLVRRSAFREVGGFDERYFMYMEDVDLG-----DRLGK
MAV_4230|M.avium_104 SERPVGWLSGSCLLVRRSAFERVGGFDERYFMYMEDVDLG-----DRLGK
MSMEG_1826|M.smegmatis_MC2_155 SERPVGWLSGSCLLLRRNAFDAIGGFDERYFMYMEDVDLG-----DRLDR
TH_0780|M.thermoresistible__bu TERPVGWLSGSCLLLRKAAFDEVDGFDERYFMYMEDVDLG-----DRLAK
MAB_3612c|M.abscessus_ATCC_199 SERVVGWLSGSCLLLRRTAFDAIGGFDPRYFMYMEDVDLG-----DRLAR
Mflv_1501|M.gilvum_PYR-GCK RKIAEARYVVTISHYNRALLERHNPAGIPVRVVHAGIDTGRYHFRPRGIP
Mvan_5245|M.vanbaalenii_PYR-1 RKIADACYVVTISQYNRALLEQHNSMGTPIRVVHAGIDVGAYRFRARGVP
: . : : . . * *
MMAR_4505|M.marinum_M AGWRVLLADELGAQQGGAPPTGAETGPTVTAGERRRTRDVIRANDALLLE
MUL_4676|M.ulcerans_Agy99 AGWRVLLADELGAQQGGAPPTGAETGPTVTAGERRRTRDVIRANDALLLE
Mb3293c|M.bovis_AF2122/97 AGWLSVYVPSAEVLHHKAHSTGRDP-----------------------AS
Rv3265c|M.tuberculosis_H37Rv AGWLSVYVPSAEVLHHKAHSTGRDP-----------------------AS
MLBr_00752|M.leprae_Br4923 AGWLSVYVPSAEVLHHKGHSTGRDP-----------------------VS
MAV_4230|M.avium_104 AGWLSVYVPSAEVLHHKGHSTGADP-----------------------AS
MSMEG_1826|M.smegmatis_MC2_155 AGWQNIYVPSAEVLHYKGHSTGRDP-----------------------AR
TH_0780|M.thermoresistible__bu AGWQNIYVPSSEILHYKGHAAGRDP-----------------------AR
MAB_3612c|M.abscessus_ATCC_199 AGWQNVYAPSSEVVHAKGHAAGRDP-----------------------AR
Mflv_1501|M.gilvum_PYR-GCK TEGPVRALTVASLQQYKGHAVLLEALAIGGPA----------------VE
Mvan_5245|M.vanbaalenii_PYR-1 AEGEVRALTVASLQQYKGHAVLLEALAMGGPE----------------VD
: : . .. :.
MMAR_4505|M.marinum_M HQCSVHHADAYLATTKVLQRLRRAQRRAIRNT---GAGKRRPAIVIATNR
MUL_4676|M.ulcerans_Agy99 HQCSVHHADAYLATTKVLQRLRRAQRRAIRNT---DAGKRRPAIVIATNR
Mb3293c|M.bovis_AF2122/97 HLAAHHKSTYIFLADRHSGWWRAPLRWTLR-----GSLALRSHLMVR---
Rv3265c|M.tuberculosis_H37Rv HLAAHHKSTYIFLADRHSGWWRAPLRWTLR-----GSLALRSHLMVRSSL
MLBr_00752|M.leprae_Br4923 HLAAHHKSTYIFLADRHSGWWRAPLRWMLR-----GSLVVRSRLMVRSSR
MAV_4230|M.avium_104 HLAAHHRSTYMFLADRYSGWMRAPLRWALR-----ASLAVRARLMVR---
MSMEG_1826|M.smegmatis_MC2_155 NLAAHHRSTYTFLADRYPATWQAPLRWAIR-----GALAVRAGLVVG---
TH_0780|M.thermoresistible__bu NLVAHHRSTYTFLADRYPRWWQSPLRWTIR-----GALAVRANLAVG---
MAB_3612c|M.abscessus_ATCC_199 SLGAHHDSVYIFQSDRHPHWWQAPLRWSIR-----GALAARSAIVVR---
Mflv_1501|M.gilvum_PYR-GCK RITLDLIGDGVLRPHLEALVERWGLRERVRFRGSCSEDVVRAALDAADLF
Mvan_5245|M.vanbaalenii_PYR-1 RITLDLIGDGVLRGDLEALVDRLGLRDRVRFLGSCSEEAVRAALDAADLF
. : : * :* *. :
MMAR_4505|M.marinum_M LVYGGAERQKALLAAELDRRGYPVTIVCVQRFGPLIKEIPDTVRVVRQPW
MUL_4676|M.ulcerans_Agy99 LVYGGAERQKALLAAELDRRGYPVTIVCVQRFGPLIKEIPDTVRVVRQPW
Mb3293c|M.bovis_AF2122/97 --RSRRRKLKLVEGRH----------------------------------
Rv3265c|M.tuberculosis_H37Rv R-RSRRRKLKLVEGRH----------------------------------
MLBr_00752|M.leprae_Br4923 RKQAAKQARQLAEGRR----------------------------------
MAV_4230|M.avium_104 --SALRESGRRVEGRH----------------------------------
MSMEG_1826|M.smegmatis_MC2_155 --NSRRK--RANKG----------------AW------------------
TH_0780|M.thermoresistible__bu --NSRRKQARVRPGEERPARNPARNTDMGTTW------------------
MAB_3612c|M.abscessus_ATCC_199 --AAIRANRRRDKQGG----------------------------------
Mflv_1501|M.gilvum_PYR-GCK VLPSLVADDGQMEGLPVVLMEALACGVPTVATDLSG--------------
Mvan_5245|M.vanbaalenii_PYR-1 VLPSIVADDGQMEGLPVALMEALACGVPAVSTKLSG--------------
.
MMAR_4505|M.marinum_M WAPIVDVGPGPAVLISGDTNTETGFATLWRAAGRRRRWLVAAHIPPLEVG
MUL_4676|M.ulcerans_Agy99 WAPIVDVGPGPAVLISGDTNTETGFATLWRAAGRRRRWLVAAHIPPLEDG
Mb3293c|M.bovis_AF2122/97 --------------------------------------------------
Rv3265c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00752|M.leprae_Br4923 --------------------------------------------------
MAV_4230|M.avium_104 --------------------------------------------------
MSMEG_1826|M.smegmatis_MC2_155 --------------------------------------------------
TH_0780|M.thermoresistible__bu --------------------------------------------------
MAB_3612c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1501|M.gilvum_PYR-GCK IPEIVVDGVTGLLAQPGDAASLNRALTAMIERGGDAEVFTGPGRELVTRE
Mvan_5245|M.vanbaalenii_PYR-1 IPEIVVDGVTGLLATPGDAASLNATLTAMVQRGTAAVEFADAGRALVSRE
MMAR_4505|M.marinum_M PIYSGPLTAAMRRADGFIVLAQRHWDMLTPYHRLGGPRFVAPNGVAVTDR
MUL_4676|M.ulcerans_Agy99 PIYSRPLTAAMRRADGFIVLAQLHWDMLTPYHRLGGPRFVAPNGVAVTDR
Mb3293c|M.bovis_AF2122/97 --------------------------------------------------
Rv3265c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00752|M.leprae_Br4923 --------------------------------------------------
MAV_4230|M.avium_104 --------------------------------------------------
MSMEG_1826|M.smegmatis_MC2_155 --------------------------------------------------
TH_0780|M.thermoresistible__bu --------------------------------------------------
MAB_3612c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1501|M.gilvum_PYR-GCK FDLRESIDALTGLLDEYVPALPAQR-------------------------
Mvan_5245|M.vanbaalenii_PYR-1 FDLRESIAALTGLLDEYLPPVAS---------------------------
MMAR_4505|M.marinum_M PAGRSRPAGAPPHLVMLSRIVEHKNPHLLIEALSGITELPWTLSIFGDGP
MUL_4676|M.ulcerans_Agy99 PAGRSRPAGAPPHLVMLSRIVEHKNPHQLIEALSGITELPWTLSIFGDGP
Mb3293c|M.bovis_AF2122/97 --------------------------------------------------
Rv3265c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00752|M.leprae_Br4923 --------------------------------------------------
MAV_4230|M.avium_104 --------------------------------------------------
MSMEG_1826|M.smegmatis_MC2_155 --------------------------------------------------
TH_0780|M.thermoresistible__bu --------------------------------------------------
MAB_3612c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1501|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5245|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4505|M.marinum_M DRERLQARTPERLRDRVHWRGWSPGPGPALADADLLCVPSRSEAFPLVIL
MUL_4676|M.ulcerans_Agy99 DRERLQARTPERLRDRVHWRGWSPGPGPALADADLLCVPSRSEAFPLVIL
Mb3293c|M.bovis_AF2122/97 --------------------------------------------------
Rv3265c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00752|M.leprae_Br4923 --------------------------------------------------
MAV_4230|M.avium_104 --------------------------------------------------
MSMEG_1826|M.smegmatis_MC2_155 --------------------------------------------------
TH_0780|M.thermoresistible__bu --------------------------------------------------
MAB_3612c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1501|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5245|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4505|M.marinum_M EAMARAVPVAASAICAVPEMLDFGGAGFVVEPVTVSAWRERLAQILADPG
MUL_4676|M.ulcerans_Agy99 EAMARAVPVAASAICAVPEMLDFGGAGFVVEPVTVSAWQERLAQILADPG
Mb3293c|M.bovis_AF2122/97 --------------------------------------------------
Rv3265c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00752|M.leprae_Br4923 --------------------------------------------------
MAV_4230|M.avium_104 --------------------------------------------------
MSMEG_1826|M.smegmatis_MC2_155 --------------------------------------------------
TH_0780|M.thermoresistible__bu --------------------------------------------------
MAB_3612c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1501|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5245|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4505|M.marinum_M ELPAVGQRGFARMRKHYTVAAMTDAYLDAIHAVL
MUL_4676|M.ulcerans_Agy99 GLPAVGQRGFARMRKHYTVAAMTDAYLDAIHAVL
Mb3293c|M.bovis_AF2122/97 ----------------------------------
Rv3265c|M.tuberculosis_H37Rv ----------------------------------
MLBr_00752|M.leprae_Br4923 ----------------------------------
MAV_4230|M.avium_104 ----------------------------------
MSMEG_1826|M.smegmatis_MC2_155 ----------------------------------
TH_0780|M.thermoresistible__bu ----------------------------------
MAB_3612c|M.abscessus_ATCC_199 ----------------------------------
Mflv_1501|M.gilvum_PYR-GCK ----------------------------------
Mvan_5245|M.vanbaalenii_PYR-1 ----------------------------------