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M. tuberculosis H37Rv Rv3265c (wbbL1)

annotation: PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE WBBL1 (ALPHA-L-RHAMNOSE-(1->3)-ALPHA-D-GlcNAc(1->P)-P-DECAPRENY L)
coordinates: 3645979 - 3646884
length: 301

TDVLPVVAVTYSPGPHLERFLASLSLATERPVSVLLADNGSTDGTPQAAVQRYPNVRLLPTGANLGYGTA
VNRTIAQLGEMAGDAGEPWVDDWVIVANPDVQWGPGSIDALLDAASRWPRAGALGPLIRDPDGSVYPSAR
QMPSLIRGGMHAVLGPFWPRNPWTTAYRQERLEPSERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMED
VDLGDRLGKAGWLSVYVPSAEVLHHKAHSTGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLA
LRSHLMVRSSLRRSRRRKLKLVEGRH*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv3265c wbbL1 - 100% (301) PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE WBBL1 (ALPHA-L-RHAMNOSE-(1->3)-ALPHA-D-GlcNAc(1->P)-P-DECAPRENY L)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3293c wbbL1 1e-176 98.67% (301) dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol
M. gilvum PYR-GCK Mflv_4735 - 1e-120 68.73% (291) glycosyl transferase family protein
M. leprae Br4923 MLBr_00752 wbbL 1e-153 85.05% (301) putative dTDP-rhamnosyl transferase
M. abscessus ATCC 19977 MAB_3612c - 1e-112 63.36% (292) putative dTDP-rhamnosyltransferase
M. marinum M MMAR_1276 wbbL1 1e-151 85.05% (301) dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3-
M. avium 104 MAV_4230 - 1e-146 83.72% (301) dTDP-RhA:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl
M. smegmatis MC2 155 MSMEG_1826 - 1e-126 72.35% (293) dTDP-RhA:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl
M. thermoresistible (build 8) TH_0780 wbbL 1e-125 70.10% (291) PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL POLYPRENOL,
M. ulcerans Agy99 MUL_2611 wbbL1 1e-151 84.72% (301) dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol A-3-
M. vanbaalenii PYR-1 Mvan_1728 - 1e-127 72.51% (291) glycosyl transferase family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4735|M.gilvum_PYR-GCK          ------MSD-----ELFVVTVTYSPGPHLERFLATLAHATDRPVTVIIAD
Mvan_1728|M.vanbaalenii_PYR-1       ------MSD-----ELFVVTVTYSPGPHLDRFLATLSLATDRPVTVIMAD
MSMEG_1826|M.smegmatis_MC2_155      ----------------MVVTVTYSPGPHLDRFLSSLSLATDRPVTVIMAD
TH_0780|M.thermoresistible__bu      ------VSD-----HLVVVTVTYSPGPHLERFLASLEHATERPVTVIMAD
Rv3265c|M.tuberculosis_H37Rv        -----------------MVAVTYSPGPHLERFLASLSLATERPVSVLLAD
Mb3293c|M.bovis_AF2122/97           -----------------MVAVTYSPGPHLERFLASLSLATERPVSVLLAD
MMAR_1276|M.marinum_M               ------MTD-----VLPVVAVTYSPGPHLERFLASLSLATDRPVSVLLAD
MUL_2611|M.ulcerans_Agy99           ------MTD-----VLPVVAVTYSPGPHLERFLASLSLATDRPVSVLLAD
MLBr_00752|M.leprae_Br4923          ------MTD-----VLPVVAVTYSPGPHLERFLASLALATDRPVSVVLAD
MAV_4230|M.avium_104                --------------MLPVVTVTYSPGPHLERFLASLSLATEREVCVLLAD
MAB_3612c|M.abscessus_ATCC_199      MLDPHRVSDSPAIGQVAVVTVTYSPGEHLHRFLRTLRHATDLPLRVILAD
                                                     :*:****** **.*** :*  **:  : *::**

Mflv_4735|M.gilvum_PYR-GCK          NGSTDGAPEEAVERHPNARLFRTGGNLGYGTAVNRAVTEYGLASS-----
Mvan_1728|M.vanbaalenii_PYR-1       NGSTDGAPEEAVERYRNVNLFRTGDNLGYGTAVNRAVAEYGLTSR-----
MSMEG_1826|M.smegmatis_MC2_155      NGSTDGTPEEAEQRYPNVRLLRTGANLGYGSAVNRAVAQLTAGEG-----
TH_0780|M.thermoresistible__bu      NGSTDGAPEEALERYPNVRLMRTGANLGYGTAINRAVAEHLADTDP----
Rv3265c|M.tuberculosis_H37Rv        NGSTDGTPQAAVQRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEP
Mb3293c|M.bovis_AF2122/97           NGSTDGTPQAAVQRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEP
MMAR_1276|M.marinum_M               NGSTDGTPQAAVERYPNVRIFHTGANLGYGTAVNRAVAQLTE------QP
MUL_2611|M.ulcerans_Agy99           NGSTDGTPQAAVERYPNVRIFHTGANLGYGTAVNRAVAQLTE------QP
MLBr_00752|M.leprae_Br4923          NGSTDGTPQVAVERYVNVRLFETGANLGYGTAANLAIAQFFEEGGATGQP
MAV_4230|M.avium_104                NGSTDGTPQAAVERYPNVRLFHTGANLGYGTAVNRAVAQLDR--------
MAB_3612c|M.abscessus_ATCC_199      NGSTDGAPEAAAE-EPDVELLRTGGNVGYGKAANLGVAQVDP--------
                                    ******:*: * :   :..:: ** *:***.* *  :::           

Mflv_4735|M.gilvum_PYR-GCK          --TDFFIVANPDVQWGPHSIDLLCEAAQRWPQAGSLGPLIRDPDGAIYPS
Mvan_1728|M.vanbaalenii_PYR-1       --SDFFIVANPDVQWGPRSIDLLLEAAARWPRAGALGPLIRDPDGAVYPS
MSMEG_1826|M.smegmatis_MC2_155      --TDFLVVANPDVQWGPKAIDLLLEASDRWPHAGAFGPLIRDPDGAIYPS
TH_0780|M.thermoresistible__bu      --SDFFVVANPDVQWGPNSIDNLLAAAARWPRAAALGPLIRDADGSVYPS
Rv3265c|M.tuberculosis_H37Rv        WVDDWVIVANPDVQWGPGSIDALLDAASRWPRAGALGPLIRDPDGSVYPS
Mb3293c|M.bovis_AF2122/97           WVDDWVIVANPDVQWGPGSIDALLDAASRWPRAGALGPLIRDPDGSVYPS
MMAR_1276|M.marinum_M               EPDDWLIVANPDVQWGPGSIDALLEAVERWPQAGALGPLIRDPDGSVYPS
MUL_2611|M.ulcerans_Agy99           EPDDWLIVANPDVQWGPGSIDALLEAVERWPQAGALGPLIRDPDGSVYPS
MLBr_00752|M.leprae_Br4923          WVDDWVIVANPDVQWGPGSIDALLDAAARWPRAGALGPLIRDPDGSVYPS
MAV_4230|M.avium_104                -GGEWVIVANPDVQWGPGSIDALLDAAARWPRAGALGPLVRDPDGSVYPS
MAB_3612c|M.abscessus_ATCC_199      -AAEWVVIANPDVQWGPGSIDAMLEVAQRWPAAGAVGPLIREPDGTVYPS
                                       ::.::********* :** :  .  *** *.:.***:*:.**::***

Mflv_4735|M.gilvum_PYR-GCK          ARHQPSIIRGGMHAVVAPVWPSNPWTAAYRQDRAEPSERTVGWLSGSCLL
Mvan_1728|M.vanbaalenii_PYR-1       ARHLPSIIRGGMHAVVGPVWPSNPWTTAYRQERADPSEREVGWLSGSCLL
MSMEG_1826|M.smegmatis_MC2_155      ARHQPSLLRGGLHAVVGPFWKNNPWTAAYRQDRQEPSERPVGWLSGSCLL
TH_0780|M.thermoresistible__bu      AREQPSLIRGGMHAVIGPLWPGNPWTAAYRQDRMEPTERPVGWLSGSCLL
Rv3265c|M.tuberculosis_H37Rv        ARQMPSLIRGGMHAVLGPFWPRNPWTTAYRQERLEPSERPVGWLSGSCLL
Mb3293c|M.bovis_AF2122/97           ARQMPSLIRGGMHAVLGPFWPRNPWTTAYRQERLEPSERPVGWLSGSCLL
MMAR_1276|M.marinum_M               ARHLPSLVRGGMHAVLGPVWPRNPWTKAYRQEHLEPSERPVGWLSGSCLL
MUL_2611|M.ulcerans_Agy99           ARHLPSLVRGGMHAVLGPVWPRNPWTKAYRQEHLEPSERPVGWLSGSCLL
MLBr_00752|M.leprae_Br4923          ARHLPSLVRGGMHAVLGPVWPRNPWTAAYRQERLELTERPVGWLSGSCLL
MAV_4230|M.avium_104                ARHLPSLVRGGMHAVVGPFWKNNPWSTAYRQERLEPSERPVGWLSGSCLL
MAB_3612c|M.abscessus_ATCC_199      ARVVPTLTGGALHALLGSVWSTNPWTAAYRQDRMEPSERVVGWLSGSCLL
                                    **  *::  *.:**::...*  ***: ****:: : :** **********

Mflv_4735|M.gilvum_PYR-GCK          LRTAAFAQIDGFNERYFMYMEDVDLGDRLETAGWQNVYVPSAEVLHAKGH
Mvan_1728|M.vanbaalenii_PYR-1       LRSSAYSEIAGFDERYFMYMEDVDLGDRLGRAGWQNVYVPSAEVLHDKGH
MSMEG_1826|M.smegmatis_MC2_155      LRRNAFDAIGGFDERYFMYMEDVDLGDRLDRAGWQNIYVPSAEVLHYKGH
TH_0780|M.thermoresistible__bu      LRKAAFDEVDGFDERYFMYMEDVDLGDRLAKAGWQNIYVPSSEILHYKGH
Rv3265c|M.tuberculosis_H37Rv        VRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWLSVYVPSAEVLHHKAH
Mb3293c|M.bovis_AF2122/97           VRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWLSVYVPSAEVLHHKAH
MMAR_1276|M.marinum_M               VRRSAFRQIGGFDERYFMYMEDVDLGDRLGQAGWLSVYVPSAEVLHHKGH
MUL_2611|M.ulcerans_Agy99           VRRSAFRQIGGFDERYFMYMEDVDLGDRLGQAGWLSVYVPSAEVLHHKGH
MLBr_00752|M.leprae_Br4923          VRRSAFREVGGFDERYFMYMEDVDLGDRLGKAGWLSVYVPSAEVLHHKGH
MAV_4230|M.avium_104                VRRSAFERVGGFDERYFMYMEDVDLGDRLGKAGWLSVYVPSAEVLHHKGH
MAB_3612c|M.abscessus_ATCC_199      LRRTAFDAIGGFDPRYFMYMEDVDLGDRLARAGWQNVYAPSSEVVHAKGH
                                    :*  *:  : **: ***************  *** .:*.**:*::* *.*

Mflv_4735|M.gilvum_PYR-GCK          ATGRDPARNLAAHHVSTYTFLADRYPKWWQAPLRWAFRTALGARASLVVR
Mvan_1728|M.vanbaalenii_PYR-1       STGRDPARNLAAHHVSTYTFLADRYPRWWQAPLRWAFRGALGARASLVVR
MSMEG_1826|M.smegmatis_MC2_155      STGRDPARNLAAHHRSTYTFLADRYPATWQAPLRWAIRGALAVRAGLVVG
TH_0780|M.thermoresistible__bu      AAGRDPARNLVAHHRSTYTFLADRYPRWWQSPLRWTIRGALAVRANLAVG
Rv3265c|M.tuberculosis_H37Rv        STGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLALRSHLMVR
Mb3293c|M.bovis_AF2122/97           STGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLALRSHLMVR
MMAR_1276|M.marinum_M               STGRDPANHLAAHHRSTYIFLADRHAGWWRAPLRWTLRGSLAVRSRLMVR
MUL_2611|M.ulcerans_Agy99           STGRDPATHLAVHHRSTYIFLADRHAGWWRAPLRWTLRGSLAVRSRLMVR
MLBr_00752|M.leprae_Br4923          STGRDPVSHLAAHHKSTYIFLADRHSGWWRAPLRWMLRGSLVVRSRLMVR
MAV_4230|M.avium_104                STGADPASHLAAHHRSTYMFLADRYSGWMRAPLRWALRASLAVRARLMVR
MAB_3612c|M.abscessus_ATCC_199      AAGRDPARSLGAHHDSVYIFQSDRHPHWWQAPLRWSIRGALAARSAIVVR
                                    ::* **.  * .** *.* * :**:.   ::**** :* :*  *: : * 

Mflv_4735|M.gilvum_PYR-GCK          -----RSRRKS-----RQS---------------------
Mvan_1728|M.vanbaalenii_PYR-1       -----NSRRKT-----RRT---------------------
MSMEG_1826|M.smegmatis_MC2_155      -----NSRRK-------RANKG----------------AW
TH_0780|M.thermoresistible__bu      -----NSRRKQ-----ARVRPGEERPARNPARNTDMGTTW
Rv3265c|M.tuberculosis_H37Rv        SSLRRSRRRK------LKLVEGRH----------------
Mb3293c|M.bovis_AF2122/97           ----RSRRRK------LKLVEGRH----------------
MMAR_1276|M.marinum_M               -----SSRRK--------LVEGRH----------------
MUL_2611|M.ulcerans_Agy99           -----SSRRK--------LVEGRH----------------
MLBr_00752|M.leprae_Br4923          -----SSRRKQAAKQARQLAEGRR----------------
MAV_4230|M.avium_104                -----SALRE-----SGRRVEGRH----------------
MAB_3612c|M.abscessus_ATCC_199      -----AAIRAN----RRRDKQGG-----------------
                                            *

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv3265c	wbbL1	-	100% (301)	PROBABLE dTDP-RHA:A-D-GlcNAc-DIPHOSPHORYL POLYPRENOL, A-3-L-RHAMNOSYL TRANSFERASE WBBL1 (ALPHA-L-RHAMNOSE-(1->3)-ALPHA-D-GlcNAc(1->P)-P-DECAPRENY L)