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KGNAYDVTTMIARTRTALPPGPRLPRSVQDALLIRHGPRFLAACRRRYGDVFTLRVASIGTMVYVADPAV IKSVFAGDPNTLHGGAASMLRGLLGDSSLLVVDDRAHRDRRRLMLAPFHRDVIERQAGLIAEIAAENVTG WPVGTPFAAATKMSEITLEVILRTVIGTSDAARLAALRAVMPRLLDLRPWETLALAKPNLLQRGPWRSLH RRIAEADELLYAEIAEHRTDPGLSGRADTLAMLIQAAYDDGRTMADGELRDQLMTLLVAGHDNTAAGLCW ALERLTRHPAVLAKAVQAADASAAGDPAGNEYLDAVVKETLRARPVVFDLGRVLRKPIELAGYLLPEGVM VVPSIGLVHGSAALYPGPERFDPDRMLGVILGPTGWLPFGGGSRRCLGAAFAMAEMRVVLREILRRVELC PTTAVDERQKLKNVILVPHRGGRILVRAMRGVPAPD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4483 | cyp135B3 | - | 100% (457) | cytochrome P450 135B3 Cyp135B3 |
| M. marinum M | MMAR_0938 | cyp135B4 | e-175 | 70.85% (446) | cytochrome P450 135B4 Cyp135B4 |
| M. marinum M | MMAR_2978 | cyp135B6 | e-165 | 66.36% (437) | cytochrome P450 135B6 Cyp135B6 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0583 | cyp135B1 | 1e-179 | 71.30% (446) | cytochrome P450 135B1 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 4e-74 | 38.13% (438) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0568 | cyp135B1 | 1e-179 | 71.30% (446) | cytochrome P450 135B1 |
| M. leprae Br4923 | MLBr_02088 | - | 9e-14 | 26.07% (326) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_4693 | - | 1e-158 | 62.93% (437) | cytochrome P450 |
| M. avium 104 | MAV_5160 | - | 7e-77 | 38.76% (436) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_1213 | - | 1e-161 | 66.05% (430) | cytochrome P450 monooxygenase |
| M. thermoresistible (build 8) | TH_2672 | - | 1e-158 | 65.50% (429) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 9e-23 | 28.05% (385) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_1038 | - | 1e-164 | 66.59% (455) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1104|M.gilvum_PYR-GCK -------------------MRLPPTPRIPR----FLQGLGFSLSR----Q
MAV_5160|M.avium_104 --------MSEVATAPLAAVHLPPAVRGPK----LLQGIGFAVSR----R
Mb0583|M.bovis_AF2122/97 -------------MSGTSSMGLPPGPRLSG----SVQAVLMLRHG----L
Rv0568|M.tuberculosis_H37Rv -------------MSGTSSMGLPPGPRLSG----SVQAVLMLRHG----L
MMAR_4483|M.marinum_M ---MKGNAYDVTTMIARTRTALPPGPRLPR----SVQDALLIRHG----P
MSMEG_1213|M.smegmatis_MC2_155 -----------------------------------MQTAMMLRHW----S
Mvan_1038|M.vanbaalenii_PYR-1 MRDPRYGRGRAFYAGVMTPTSLPPGPRLPR----SVQAALMLRCG----P
TH_2672|M.thermoresistible__bu -----------------------------------VQAWLMLRHG----K
MAB_4693|M.abscessus_ATCC_1997 -------------MSKTAKIALPPGPPLPL----AVQSILMASYG----L
MUL_0604|M.ulcerans_Agy99 ------------MVDPPDIRSLPLAPRNPLPYWQQLKALKTLHVG----S
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
:
Mflv_1104|M.gilvum_PYR-GCK WTVAQVVRRYGDVFTMTLPVFGKTVLVTDPALAKQLFMANTD--DVGNIQ
MAV_5160|M.avium_104 TMMRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQIFTTSPD--ELGNIQ
Mb0583|M.bovis_AF2122/97 RFLTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEAN
Rv0568|M.tuberculosis_H37Rv RFLTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEAN
MMAR_4483|M.marinum_M RFLAACRRRYGDVFTLRVASIGTMVYVADPAVIKSVFAGDPNTLHGGAA-
MSMEG_1213|M.smegmatis_MC2_155 RFVSACRRRYGDVFTLRIASMGTWVYLADPADIKTVFAGDPTVFHAGEAN
Mvan_1038|M.vanbaalenii_PYR-1 RFVAACRRRYGSAFTLRVASMGTLVYLTDPADIKTVFAGDPDIYHAGEAN
TH_2672|M.thermoresistible__bu WFIAACQRRYGPVFTLRITSMGTLVYLTDPADIKAVFTGDPDTFHAGEAN
MAB_4693|M.abscessus_ATCC_1997 RFLAGCQRRYGNMFTLRIPLSGKVVYLADPADIKTVYAGDPHVFHSGEAH
MUL_0604|M.ulcerans_Agy99 EALRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVLGRSGALSDRGTLP
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
: : .
Mflv_1104|M.gilvum_PYR-GCK PNLSRVLGS----GSVFALDGTDHRLRRKLLTPPFHGKSIKNYERIFEEE
MAV_5160|M.avium_104 PNLSRLFGS----GSVFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIEEE
Mb0583|M.bovis_AF2122/97 SMLAGLLGD----SSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEI
Rv0568|M.tuberculosis_H37Rv SMLAGLLGD----SSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEI
MMAR_4483|M.marinum_M SMLRGLLGD----SSLLVVDDRAHRDRRRLMLAPFHRDVIERQAGLIAEI
MSMEG_1213|M.smegmatis_MC2_155 SMLSGLLGE----TSVLVIDEDVHRDRRRLMLAPFARDAVARQTGVMAEV
Mvan_1038|M.vanbaalenii_PYR-1 SMLKGLLGD----TSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEI
TH_2672|M.thermoresistible__bu SMLSGILGE----TSVLVIDGDLHRRRRRLMLPSFHRDAVTRQADAMAEI
MAB_4693|M.abscessus_ATCC_1997 WFFRGLLGD----SSLFVLDEDEHHHQRRLLMPAFHRDAVARQATQMAQI
MUL_0604|M.ulcerans_Agy99 LLKDLRRAIG---ESVLNLPHDTWLPRRRTLQPIFTKQRVAGFAGHMSEA
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
*.: : *: : * . : :
Mflv_1104|M.gilvum_PYR-GCK TLREAASWPEGQPFETLEPMMRITLNAILRAVFGADG-AHLDELRRIIPP
MAV_5160|M.avium_104 TLRETAGWPEGESFPTLPPMMRITLNAILRAVFGAEG-AELDELRRLIPP
Mb0583|M.bovis_AF2122/97 AAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPR
Rv0568|M.tuberculosis_H37Rv AAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPR
MMAR_4483|M.marinum_M AAENVTGWPVGTPFAAATKMSEITLEVILRTVIGTSDAARLAALRAVMPR
MSMEG_1213|M.smegmatis_MC2_155 AATNIASWPVGTPFPVAPKMAEIALEVILRTVIGATEPARLAALRHVMPQ
Mvan_1038|M.vanbaalenii_PYR-1 AADNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPR
TH_2672|M.thermoresistible__bu AAADIAGWPVGTTFAAAPRMSQITLEVILRVVIGAGDPGRLAALRTVLPR
MAB_4693|M.abscessus_ATCC_1997 AAANIAEWPVGESFPVAPRTTDITLEVILRTVIGASDPVRLAALRKVVPR
MUL_0604|M.ulcerans_Agy99 ANHILLGWPDGAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVTL
MLBr_02088|M.leprae_Br4923 VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALL
. . . . .: ::*
Mflv_1104|M.gilvum_PYR-GCK WVTLGSRLAVLPTPHRTYGRFSPWGRLARYRRRYDEVIGRLIDAVQADPN
MAV_5160|M.avium_104 WVTLGSRLAALPKPQR-YPRFGPWGQLDRWRRQYDGVIERLIAAEQADPN
Mb0583|M.bovis_AF2122/97 LLNVGP-WATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPD
Rv0568|M.tuberculosis_H37Rv LLNVGP-WATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPD
MMAR_4483|M.marinum_M LLDLRP-WETLALAKPNLLQRGPWRSLHRRIAEADELLYAEIAEHRTDPG
MSMEG_1213|M.smegmatis_MC2_155 LLGIGP-WQSLAIASPGLQRRRPWRTLQRNLAEADRLLYAEIAACRAGPD
Mvan_1038|M.vanbaalenii_PYR-1 VLSVGP-WETLAIANQDLLRRRPWRAVRDAIAEADRLLYAEIADRRADPD
TH_2672|M.thermoresistible__bu LIDIGP-WLSLAVASPHLQRHRPWQRLQRNLADADRLLYAEIAERRADPE
MAB_4693|M.abscessus_ATCC_1997 LLYMKP-WETPAITNPGLRRYWPWTAVGRRMAETDALLYAEIAERRADPN
MUL_0604|M.ulcerans_Agy99 AAKWAADRSARPVRAPHWLPTPARPRARGAYDAMYKIAADMLAACRADPS
MLBr_02088|M.leprae_Br4923 VQSVDP-FITITGEPPEATEER-----LRAGVWLRDYLEQLVKCRRGTPG
. . : : *
Mflv_1104|M.gilvum_PYR-GCK FESRDDVLALLLRSTYEDGSSMSRQDIGDELLTLLAAGHETTAATLGWVF
MAV_5160|M.avium_104 FAERTDVLALLLRSTYDDGAAMSHKEIGDELLTLLAAGHETTASTLAWAF
Mb0583|M.bovis_AF2122/97 LAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWAL
Rv0568|M.tuberculosis_H37Rv LAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWAL
MMAR_4483|M.marinum_M LSGRADTLAMLIQAAYDDGRTMADGELRDQLMTLLVAGHDNTAAGLCWAL
MSMEG_1213|M.smegmatis_MC2_155 LASRPDALAMLVRAANDEGRTMTDRELRDQLMTLLVAGHETTATGLSWTL
Mvan_1038|M.vanbaalenii_PYR-1 LDTRTDALAMLVRAG-----DMSDKELRDQLITLLVAGHDTTATALSWAL
TH_2672|M.thermoresistible__bu LDTRTDTLAMLVRSADDDGQAMSDRELRDQLMTLLLAGHDTTATALSWAL
MAB_4693|M.abscessus_ATCC_1997 LTERTDVLAMLVRATDDDGRTMSDQELRDHLLTSIAAGHETTATALSWVL
MUL_0604|M.ulcerans_Agy99 RE-APLITALIDATGPNTGESLSDQQICDEMVYFMILGEDTTSTVLTYAL
MLBr_02088|M.leprae_Br4923 ED-----LISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAV
:: :: : *.:.* : ..
Mflv_1104|M.gilvum_PYR-GCK ERISRHPDVLARLQAEAD-----------TDGNEYRQAVILETQRVRTVI
MAV_5160|M.avium_104 ERISRHPELLARLVEEAD-----------NGGNELRQAAILEVQRARTVI
Mb0583|M.bovis_AF2122/97 ERLTRHPVTLAKAVQAADAS-----AAGDPAGDEYLDAVAKETLRIRPVV
Rv0568|M.tuberculosis_H37Rv ERLTRHPVTLAKAVQAADAS-----AAGDPAGDEYLDAVAKETLRIRPVV
MMAR_4483|M.marinum_M ERLTRHPAVLAKAVQAADAS-----AAGDPAGNEYLDAVVKETLRARPVV
MSMEG_1213|M.smegmatis_MC2_155 ERLIRHPAVLDKAVAAAR--------TTDGSGEAYLDAVVRESLRIRPVV
Mvan_1038|M.vanbaalenii_PYR-1 ERLTRHPAVLAKAVRAAR--------DGD---DDYLDAVAKETLRDRPVV
TH_2672|M.thermoresistible__bu ERLTRHPMLLAEAEQAAEAS-----AAGDPAGDEYLDAVCRETLRNRTVV
MAB_4693|M.abscessus_ATCC_1997 ERLTRHPDALLKAAQAAEAS-----AAGDPAGDEYLDAVVKETLRIRPVI
MUL_0604|M.ulcerans_Agy99 WALGQHCQLQDRLAAEAAELGDRPLTPADVPRLGYTIQVLQEAMRLRPPG
MLBr_02088|M.leprae_Br4923 LAMLRNPSQWKALSSNPQ----------------RAPLVVEETLRYDPAI
: :: . . * * .
Mflv_1104|M.gilvum_PYR-GCK DFAGRHVYAPTFELGEWIIPQGYSIVVAIGQVHHREQDYLDPEDFDPQRF
MAV_5160|M.avium_104 DFAGRHVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFDPQRF
Mb0583|M.bovis_AF2122/97 YDVGR-VLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRM
Rv0568|M.tuberculosis_H37Rv YDVGR-VLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRM
MMAR_4483|M.marinum_M FDLGR-VLRKPIELAGYLLPEGVMVVPSIGLVHGSAALYPGPERFDPDRM
MSMEG_1213|M.smegmatis_MC2_155 FEAGR-VLTEPVELGGYLLPAGTLVAPSIGLVHASADVYPDPDRFEPDRM
Mvan_1038|M.vanbaalenii_PYR-1 FDVGR-VLKAPVELAGYRLPAGVMVIPGLVAVHADSQIYPHADRFDPDRM
TH_2672|M.thermoresistible__bu FDVGR-VLKRPVELAGHRLPAGVMVVPGMVRVHADGELYPDPERFDPHRM
MAB_4693|M.abscessus_ATCC_1997 FSSGR-VLKESVEVGGYQLPVGIMVDPAIGLVHASGAVYPDPARFDPDRM
MUL_0604|M.ulcerans_Agy99 PTVAR-RAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFDPDRF
MLBr_02088|M.leprae_Br4923 HLIGR-VAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRP
.* : : * : : : . *:*.*
Mflv_1104|M.gilvum_PYR-GCK VGQR-----PSTLSHIPFGGGTRRCVGAVFANVEMDIVLRTVFRHFTIET
MAV_5160|M.avium_104 IDNK-----PSALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTIET
Mb0583|M.bovis_AF2122/97 VGAT-----LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELST
Rv0568|M.tuberculosis_H37Rv VGAT-----LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELST
MMAR_4483|M.marinum_M LGVI-----LGPTGWLPFGGGSRRCLGAAFAMAEMRVVLREILRRVELCP
MSMEG_1213|M.smegmatis_MC2_155 LAST-----QAPSTWLPFGGGNRRCLGATFALVEMRVVLREILHRVDLFA
Mvan_1038|M.vanbaalenii_PYR-1 LGAT-----LSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRVELET
TH_2672|M.thermoresistible__bu LGETPGQPALTPTTWFPFGGGNRRCLGATFAMVEMRVVLREILRRVELET
MAB_4693|M.abscessus_ATCC_1997 VGTT-----LSPTTWLPFGGGNRRCLGATFAMVEIRVVLREILRRVELNT
MUL_0604|M.ulcerans_Agy99 APKKS--KGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATIIREAEIHS
MLBr_02088|M.leprae_Br4923 SSRH-----------LAFAVGSHFCLGAALARLEATVTLSAIS--ARFPQ
:.*. * : *:* :* * :.* : :
Mflv_1104|M.gilvum_PYR-GCK TTAPGEKMHSRGVAYTPDDGGRVVMRRR----------------------
MAV_5160|M.avium_104 TDAPDEPWHCRGVAFTPKHGGRIVVHRR----------------------
Mb0583|M.bovis_AF2122/97 TTTSGERPKLKHVIMVPHRGARIRVRATR--------DVSATSQATAQGA
Rv0568|M.tuberculosis_H37Rv TTTSGERPKLKHVIMVPHRGARIRVRATR--------DVSATSQATAQGA
MMAR_4483|M.marinum_M TTAVDERQKLKNVILVPHRGGRILVRAMR--------GVPAPD-------
MSMEG_1213|M.smegmatis_MC2_155 TTARGEKQRLKHVTMIPHRGGRICVRALR--------DVAPAPMTCPAEA
Mvan_1038|M.vanbaalenii_PYR-1 TTARGEHRRLKHVIFVPHRGARIRVRAKR--------VVAAEAPKCPMSG
TH_2672|M.thermoresistible__bu TSARGERPRLKHVVFVPRRGARIRVRAHRKPVADNTVDDAAGPVPSPVPP
MAB_4693|M.abscessus_ATCC_1997 TTAPDEKQQAKHVTFVPHRGGSISVRAIR-------TCAPAVTPTCPADV
MUL_0604|M.ulcerans_Agy99 LDG--DFPVAIPLPIVPAGPIRARVNQRR--------PSQEVCTTTLSDS
MLBr_02088|M.leprae_Br4923 VQLAGELVYKPNVAMRGMSALPVQV-------------------------
: : :
Mflv_1104|M.gilvum_PYR-GCK -----------------
MAV_5160|M.avium_104 -----------------
Mb0583|M.bovis_AF2122/97 GCPAARGGGPSRAVGSQ
Rv0568|M.tuberculosis_H37Rv GCPAARGGGPSRAVGSQ
MMAR_4483|M.marinum_M -----------------
MSMEG_1213|M.smegmatis_MC2_155 RRA--------------
Mvan_1038|M.vanbaalenii_PYR-1 PA---------------
TH_2672|M.thermoresistible__bu RR---------------
MAB_4693|M.abscessus_ATCC_1997 HGTGQARDPQR------
MUL_0604|M.ulcerans_Agy99 SASS-------------
MLBr_02088|M.leprae_Br4923 -----------------