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M. marinum M MMAR_2978 (cyp135B6)

annotation: cytochrome P450 135B6 Cyp135B6
coordinates: 3603061 - 3604482
length: 473

VPHSNSGVLPPGPPLSRSLQAALMLLRGPQFLAACRRRYGDVFTLRIARMGTQVYLADPRDIKTVFTGDT
HIFHAGDANALLSGLIGDSSLMVLDEEAHRCRRRTMLAPFHRDAVARQAGLMAEIAADNVAGWPAGRTFP
VTVRMSEITLEVILRTVIGATDPARLAALRTAVPRLLSMGPWGTLALANPKLLSRRPWRGLRKRIADVDN
LLYAEITDRRNDAELGKRADVLAMLIRTEGNDNAMTDRELRDQLVTLLVAGYDTSATGLAWALERLTRHP
TILTRAVAAAHASAAGDAAGDEYLDAVVKETLRIRPLAFAVGRVLAAPVEVAGYQLPAGAWALPGIGLVH
ASAALYPDPDRFDPDRMIGVSPGPTTWLPFGGGARRCLGATFALVEMRVVLREVLRRAELITTTAADETP
KLKYVTLIPSRGARISVRTIKNIPPASPVGAEKPATTPGCPATENVGATRPAF
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_2978cyp135B6-100% (473)cytochrome P450 135B6 Cyp135B6
M. marinum MMMAR_0938cyp135B4e-17165.44% (463) cytochrome P450 135B4 Cyp135B4
M. marinum MMMAR_4483cyp135B3e-16566.36% (437) cytochrome P450 135B3 Cyp135B3

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0583cyp135B11e-17365.66% (463) cytochrome P450 135B1
M. gilvum PYR-GCKMflv_1104-9e-6636.90% (439) cytochrome P450
M. tuberculosis H37RvRv0568cyp135B11e-17365.66% (463) cytochrome P450 135B1
M. leprae Br4923MLBr_02088-2e-1223.51% (319) putative cytochrome p450
M. abscessus ATCC 19977MAB_4693-1e-15761.76% (455) cytochrome P450
M. avium 104MAV_5160-6e-6937.99% (437) cytochrome P450 monooxygenase
M. smegmatis MC2 155MSMEG_1213-1e-15763.40% (429) cytochrome P450 monooxygenase
M. thermoresistible (build 8)TH_2672-1e-15564.55% (426) PUTATIVE cytochrome P450
M. ulcerans Agy99MUL_0604cyp185A45e-3029.43% (333) cytochrome P450 185A4 Cyp185A4
M. vanbaalenii PYR-1Mvan_1038-1e-16265.23% (440) cytochrome P450

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1104|M.gilvum_PYR-GCK          -------------------MRLPPTPRIP--RFLQGLGFSLSRQ------
MAV_5160|M.avium_104                --------MSEVATAPLAAVHLPPAVRGP--KLLQGIGFAVSRR------
MSMEG_1213|M.smegmatis_MC2_155      ---------------------------------MQTAMMLRHWS------
Mvan_1038|M.vanbaalenii_PYR-1       MRDPRYGRGRAFYAGVMTPTSLPPGPRLP--RSVQAALMLRCGP------
TH_2672|M.thermoresistible__bu      ---------------------------------VQAWLMLRHGK------
Mb0583|M.bovis_AF2122/97            -------------MSGTSSMGLPPGPRLS--GSVQAVLMLRHGL------
Rv0568|M.tuberculosis_H37Rv         -------------MSGTSSMGLPPGPRLS--GSVQAVLMLRHGL------
MMAR_2978|M.marinum_M               -------------MPHSNSGVLPPGPPLS--RSLQAALMLLRGP------
MAB_4693|M.abscessus_ATCC_1997      -------------MSKTAKIALPPGPPLP--LAVQSILMASYGL------
MUL_0604|M.ulcerans_Agy99           ----------MVDPPDIRSLPLAPRNPLPYWQQLKALKTLHVGS------
MLBr_02088|M.leprae_Br4923          MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
                                                                      :               

Mflv_1104|M.gilvum_PYR-GCK          WTVAQVVRRYGDVFTMTLPVFGKTVLVTDPALAKQLFMANTD--DVGNIQ
MAV_5160|M.avium_104                TMMRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQIFTTSPD--ELGNIQ
MSMEG_1213|M.smegmatis_MC2_155      RFVSACRRRYGDVFTLRIASMGTWVYLADPADIKTVFAGDPTVFHAGEAN
Mvan_1038|M.vanbaalenii_PYR-1       RFVAACRRRYGSAFTLRVASMGTLVYLTDPADIKTVFAGDPDIYHAGEAN
TH_2672|M.thermoresistible__bu      WFIAACQRRYGPVFTLRITSMGTLVYLTDPADIKAVFTGDPDTFHAGEAN
Mb0583|M.bovis_AF2122/97            RFLTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEAN
Rv0568|M.tuberculosis_H37Rv         RFLTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEAN
MMAR_2978|M.marinum_M               QFLAACRRRYGDVFTLRIARMGTQVYLADPRDIKTVFTGDTHIFHAGDAN
MAB_4693|M.abscessus_ATCC_1997      RFLAGCQRRYGNMFTLRIPLSGKVVYLADPADIKTVYAGDPHVFHSGEAH
MUL_0604|M.ulcerans_Agy99           EALRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVLGRSGALSDRGTLP
MLBr_02088|M.leprae_Br4923          FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
                                      :                              :     .          

Mflv_1104|M.gilvum_PYR-GCK          PN----LSRVLGSGSVFALDGTDHRLRRKLLTPPFHGKSIKNYERIFEEE
MAV_5160|M.avium_104                PN----LSRLFGSGSVFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIEEE
MSMEG_1213|M.smegmatis_MC2_155      SM----LSGLLGETSVLVIDEDVHRDRRRLMLAPFARDAVARQTGVMAEV
Mvan_1038|M.vanbaalenii_PYR-1       SM----LKGLLGDTSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEI
TH_2672|M.thermoresistible__bu      SM----LSGILGETSVLVIDGDLHRRRRRLMLPSFHRDAVTRQADAMAEI
Mb0583|M.bovis_AF2122/97            SM----LAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEI
Rv0568|M.tuberculosis_H37Rv         SM----LAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEI
MMAR_2978|M.marinum_M               AL----LSGLIGDSSLMVLDEEAHRCRRRTMLAPFHRDAVARQAGLMAEI
MAB_4693|M.abscessus_ATCC_1997      WF----FRGLLGDSSLFVLDEDEHHHQRRLLMPAFHRDAVARQATQMAQI
MUL_0604|M.ulcerans_Agy99           LLKD--LRRAIG-ESVLNLPHDTWLPRRRTLQPIFTKQRVAGFAGHMSEA
MLBr_02088|M.leprae_Br4923          AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
                                              :   *.: :        *: :   *  . :      :   

Mflv_1104|M.gilvum_PYR-GCK          TLREAASWPEGQPFETLEPMMRITLNAILRAVFGADG-AHLDELRRIIPP
MAV_5160|M.avium_104                TLRETAGWPEGESFPTLPPMMRITLNAILRAVFGAEG-AELDELRRLIPP
MSMEG_1213|M.smegmatis_MC2_155      AATNIASWPVGTPFPVAPKMAEIALEVILRTVIGATEPARLAALRHVMPQ
Mvan_1038|M.vanbaalenii_PYR-1       AADNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPR
TH_2672|M.thermoresistible__bu      AAADIAGWPVGTTFAAAPRMSQITLEVILRVVIGAGDPGRLAALRTVLPR
Mb0583|M.bovis_AF2122/97            AAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPR
Rv0568|M.tuberculosis_H37Rv         AAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPR
MMAR_2978|M.marinum_M               AADNVAGWPAGRTFPVTVRMSEITLEVILRTVIGATDPARLAALRTAVPR
MAB_4693|M.abscessus_ATCC_1997      AAANIAEWPVGESFPVAPRTTDITLEVILRTVIGASDPVRLAALRKVVPR
MUL_0604|M.ulcerans_Agy99           ANHILLGWPDGAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVTL
MLBr_02088|M.leprae_Br4923          VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALL
                                    .       . .  .            .:   ::*                

Mflv_1104|M.gilvum_PYR-GCK          WVTLGSRLAVLPTPHRTYGRFSPWGRLARYRRRYDEVIGRLIDAVQADPN
MAV_5160|M.avium_104                WVTLGSRLAALPKPQR-YPRFGPWGQLDRWRRQYDGVIERLIAAEQADPN
MSMEG_1213|M.smegmatis_MC2_155      LLGIGP-WQSLAIASPGLQRRRPWRTLQRNLAEADRLLYAEIAACRAGPD
Mvan_1038|M.vanbaalenii_PYR-1       VLSVGP-WETLAIANQDLLRRRPWRAVRDAIAEADRLLYAEIADRRADPD
TH_2672|M.thermoresistible__bu      LIDIGP-WLSLAVASPHLQRHRPWQRLQRNLADADRLLYAEIAERRADPE
Mb0583|M.bovis_AF2122/97            LLNVGP-WATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPD
Rv0568|M.tuberculosis_H37Rv         LLNVGP-WATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPD
MMAR_2978|M.marinum_M               LLSMGP-WGTLALANPKLLSRRPWRGLRKRIADVDNLLYAEITDRRNDAE
MAB_4693|M.abscessus_ATCC_1997      LLYMKP-WETPAITNPGLRRYWPWTAVGRRMAETDALLYAEIAERRADPN
MUL_0604|M.ulcerans_Agy99           AAKWAADRSARPVRAPHWLPTPARPRARGAYDAMYKIAADMLAACRADPS
MLBr_02088|M.leprae_Br4923          VQSVDP-FITITGEPPEATEER-----LRAGVWLRDYLEQLVKCRRGTPG
                                         .     .                             :   :  . 

Mflv_1104|M.gilvum_PYR-GCK          FESRDDVLALLLRSTYEDGSSMSRQDIGDELLTLLAAGHETTAATLGWVF
MAV_5160|M.avium_104                FAERTDVLALLLRSTYDDGAAMSHKEIGDELLTLLAAGHETTASTLAWAF
MSMEG_1213|M.smegmatis_MC2_155      LASRPDALAMLVRAANDEGRTMTDRELRDQLMTLLVAGHETTATGLSWTL
Mvan_1038|M.vanbaalenii_PYR-1       LDTRTDALAMLVRAG-----DMSDKELRDQLITLLVAGHDTTATALSWAL
TH_2672|M.thermoresistible__bu      LDTRTDTLAMLVRSADDDGQAMSDRELRDQLMTLLLAGHDTTATALSWAL
Mb0583|M.bovis_AF2122/97            LAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWAL
Rv0568|M.tuberculosis_H37Rv         LAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWAL
MMAR_2978|M.marinum_M               LGKRADVLAMLIRTEGND-NAMTDRELRDQLVTLLVAGYDTSATGLAWAL
MAB_4693|M.abscessus_ATCC_1997      LTERTDVLAMLVRATDDDGRTMSDQELRDHLLTSIAAGHETTATALSWVL
MUL_0604|M.ulcerans_Agy99           R-EAPLITALIDATGPNTGESLSDQQICDEMVYFMILGEDTTSTVLTYAL
MLBr_02088|M.leprae_Br4923          EDLISRLIELD-----ESGDQLTEEEIIATCGLLLVAGHETTVNLIANAV
                                             :           :: .::       :  * :*:   :  ..

Mflv_1104|M.gilvum_PYR-GCK          ERISRHPDVLARLQAEAD-----------TDGNEYRQAVILETQRVRTVI
MAV_5160|M.avium_104                ERISRHPELLARLVEEAD-----------NGGNELRQAAILEVQRARTVI
MSMEG_1213|M.smegmatis_MC2_155      ERLIRHPAVLDKAVAAAR--------TTDGSGEAYLDAVVRESLRIRPVV
Mvan_1038|M.vanbaalenii_PYR-1       ERLTRHPAVLAKAVRAAR--------DGD---DDYLDAVAKETLRDRPVV
TH_2672|M.thermoresistible__bu      ERLTRHPMLLAEAEQAAEAS-----AAGDPAGDEYLDAVCRETLRNRTVV
Mb0583|M.bovis_AF2122/97            ERLTRHPVTLAKAVQAADAS-----AAGDPAGDEYLDAVAKETLRIRPVV
Rv0568|M.tuberculosis_H37Rv         ERLTRHPVTLAKAVQAADAS-----AAGDPAGDEYLDAVAKETLRIRPVV
MMAR_2978|M.marinum_M               ERLTRHPTILTRAVAAAHAS-----AAGDAAGDEYLDAVVKETLRIRPLA
MAB_4693|M.abscessus_ATCC_1997      ERLTRHPDALLKAAQAAEAS-----AAGDPAGDEYLDAVVKETLRIRPVI
MUL_0604|M.ulcerans_Agy99           WALGQHCQLQDRLAAEAAELGDRPLTPADVPRLGYTIQVLQEAMRLRPPG
MLBr_02088|M.leprae_Br4923          LAMLRNPSQWKALSSNPQ----------------RAPLVVEETLRYDPAI
                                      : ::          .                     .  *  *  .  

Mflv_1104|M.gilvum_PYR-GCK          DFAGRHVYAPTFELGEWIIPQGYSIVVAIGQVHHREQDYLDPEDFDPQRF
MAV_5160|M.avium_104                DFAGRHVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFDPQRF
MSMEG_1213|M.smegmatis_MC2_155      FEAGR-VLTEPVELGGYLLPAGTLVAPSIGLVHASADVYPDPDRFEPDRM
Mvan_1038|M.vanbaalenii_PYR-1       FDVGR-VLKAPVELAGYRLPAGVMVIPGLVAVHADSQIYPHADRFDPDRM
TH_2672|M.thermoresistible__bu      FDVGR-VLKRPVELAGHRLPAGVMVVPGMVRVHADGELYPDPERFDPHRM
Mb0583|M.bovis_AF2122/97            YDVGR-VLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRM
Rv0568|M.tuberculosis_H37Rv         YDVGR-VLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRM
MMAR_2978|M.marinum_M               FAVGR-VLAAPVEVAGYQLPAGAWALPGIGLVHASAALYPDPDRFDPDRM
MAB_4693|M.abscessus_ATCC_1997      FSSGR-VLKESVEVGGYQLPVGIMVDPAIGLVHASGAVYPDPARFDPDRM
MUL_0604|M.ulcerans_Agy99           PTVAR-RAMQDIEVDGYRVQAGTYCLVGVYAMHRDPALWDDPLAFDPDRF
MLBr_02088|M.leprae_Br4923          HLIGR-VAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRP
                                       .*        :    :  *      :   :     :  .  *:*.* 

Mflv_1104|M.gilvum_PYR-GCK          VGQR-----PSTLSHIPFGGGTRRCVGAVFANVEMDIVLRTVFRHFTIET
MAV_5160|M.avium_104                IDNK-----PSALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTIET
MSMEG_1213|M.smegmatis_MC2_155      LAST-----QAPSTWLPFGGGNRRCLGATFALVEMRVVLREILHRVDLFA
Mvan_1038|M.vanbaalenii_PYR-1       LGAT-----LSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRVELET
TH_2672|M.thermoresistible__bu      LGETPGQPALTPTTWFPFGGGNRRCLGATFAMVEMRVVLREILRRVELET
Mb0583|M.bovis_AF2122/97            VGAT-----LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELST
Rv0568|M.tuberculosis_H37Rv         VGAT-----LSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELST
MMAR_2978|M.marinum_M               IGVS-----PGPTTWLPFGGGARRCLGATFALVEMRVVLREVLRRAELIT
MAB_4693|M.abscessus_ATCC_1997      VGTT-----LSPTTWLPFGGGNRRCLGATFAMVEIRVVLREILRRVELNT
MUL_0604|M.ulcerans_Agy99           APKK--SKGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATIIREAEIHS
MLBr_02088|M.leprae_Br4923          SSRH-----------LAFAVGSHFCLGAALARLEATVTLSAIS--ARFPQ
                                                   :.*. * : *:*  :* :*  :.*  :     :  

Mflv_1104|M.gilvum_PYR-GCK          TTAPGEKMHSRGVAYTPDDGGRVVMRRR----------------------
MAV_5160|M.avium_104                TDAPDEPWHCRGVAFTPKHGGRIVVHRR----------------------
MSMEG_1213|M.smegmatis_MC2_155      TTARGEKQRLKHVTMIPHRGGRICVRALR----------DVAPAPMTCPA
Mvan_1038|M.vanbaalenii_PYR-1       TTARGEHRRLKHVIFVPHRGARIRVRAKR----------VVAAEAPKCPM
TH_2672|M.thermoresistible__bu      TSARGERPRLKHVVFVPRRGARIRVRAHRKP--VADNTVDDAAGPVPSPV
Mb0583|M.bovis_AF2122/97            TTTSGERPKLKHVIMVPHRGARIRVRATR----DVSATSQATAQGAGCPA
Rv0568|M.tuberculosis_H37Rv         TTTSGERPKLKHVIMVPHRGARIRVRATR----DVSATSQATAQGAGCPA
MMAR_2978|M.marinum_M               TTAADETPKLKYVTLIPSRGARISVRTIKNIPPASPVGAEKPATTPGCPA
MAB_4693|M.abscessus_ATCC_1997      TTAPDEKQQAKHVTFVPHRGGSISVRAIR---------TCAPAVTPTCPA
MUL_0604|M.ulcerans_Agy99           LDG--DFPVAIPLPIVPAGPIRARVNQRR-------------PSQEVCTT
MLBr_02088|M.leprae_Br4923          VQLAGELVYKPNVAMRGMSALPVQV-------------------------
                                         :      :           :                         

Mflv_1104|M.gilvum_PYR-GCK          -------------
MAV_5160|M.avium_104                -------------
MSMEG_1213|M.smegmatis_MC2_155      E----ARRA----
Mvan_1038|M.vanbaalenii_PYR-1       S----GPA-----
TH_2672|M.thermoresistible__bu      P----PRR-----
Mb0583|M.bovis_AF2122/97            ARGGGPSRAVGSQ
Rv0568|M.tuberculosis_H37Rv         ARGGGPSRAVGSQ
MMAR_2978|M.marinum_M               TENVGATRPAF--
MAB_4693|M.abscessus_ATCC_1997      DVHGTGQARDPQR
MUL_0604|M.ulcerans_Agy99           TLSDSSASS----
MLBr_02088|M.leprae_Br4923          -------------