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SFVVVSPEVLAVAGRDLASIGSAISQANVAAAAPTMGALAAGADEVSAAVAAVFSGHAQAYQALGAQVAA FHDQLVTALDAAAGKYASAEVANASPLQAVLDVVNAPAQALLGRPLIGNGDDGVAGTGQSGGDGGILYGN GGDGGSGASGQIGGTGGSAGLIGAGGTGGAGGLGAAGGAGGNGGWLFGQGGAGGIGGSGAAGGAGGNGGW LYGDGGAGGQGGAAAESINDGSPGQGGNGGSAYLFGNGGSGGQGGTGLAGADGVNYSNGTAGPGAWGNNV TTSIGDANGGNGGSGADGGAGVTGGTGGVGGFANNEGSGDANGGFGGTGGNGGAPGASGGEGGTGGVAIA SGGNAYGGSGGTGGNGATGASGGTGGTGGTGGDGGHGGLLIGNGGIGGIGGTGGVGGIGGTGGDGGTGGV GGSALNTGSGVADANIGGDGGDAGTGGDGGTGGVGGVGGSGGAGGLLFGNGGDGGAGGDGGVGGTGGIGG AGGNGGVGGDGSSSGTGAGGSGGDATDGGTGGDGGSGGGFGTGGAGGTGGWLIGHSGTNGIGGTGGAGGA GAVGGDGGVGGDPGVGTTYNGISGHNGVQGGTGADGAAG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_4149 | - | - | 100% (600) | PE-PGRS family protein |
M. marinum M | MMAR_2481 | - | 0.0 | 53.88% (683) | PE-PGRS family protein |
M. marinum M | MMAR_2492 | - | 0.0 | 55.09% (639) | PE-PGRS family protein, PE_PGRS15_2 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0896c | PE_PGRS15 | 0.0 | 58.59% (623) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-122 | 51.28% (507) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv0872c | PE_PGRS15 | 0.0 | 58.71% (620) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 2e-10 | 35.42% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 3e-50 | 36.21% (428) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 2e-23 | 43.68% (174) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 2e-95 | 39.78% (626) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 8e-43 | 39.51% (286) | PUTATIVE - |
M. ulcerans Agy99 | MUL_3318 | - | 1e-159 | 50.16% (644) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-121 | 46.32% (598) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mb0896c|M.bovis_AF2122/97 -------------------------------------------------- Rv0872c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4149|M.marinum_M -------------------------------------------------- MUL_3318|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb0896c|M.bovis_AF2122/97 -------------------------------------------------- Rv0872c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_4149|M.marinum_M -------------------------------------------------- MUL_3318|M.ulcerans_Agy99 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Mb0896c|M.bovis_AF2122/97 ------------------------------------------MSYVLATP Rv0872c|M.tuberculosis_H37Rv ------------------------------------------MSYVLATP MMAR_4149|M.marinum_M ------------------------------------------MSFVVVSP MUL_3318|M.ulcerans_Agy99 ------------------------------------------MSYLAIAP Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP MLBr_01183|M.leprae_Br4923 -----------------------------------------MPLFLNAEP MAV_4827|M.avium_104 -------------------------------------MNIVLGVSMAPSS Mb0896c|M.bovis_AF2122/97 ----------------------------------------EMVAAAANNL Rv0872c|M.tuberculosis_H37Rv ----------------------------------------EMVAAAANNL MMAR_4149|M.marinum_M ----------------------------------------EVLAVAGRDL MUL_3318|M.ulcerans_Agy99 ----------------------------------------EIVAAAAADM Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------------------VEAASYVADPEAAL MLBr_01183|M.leprae_Br4923 ----------------------------------------QALTAAANTL MAV_4827|M.avium_104 ----------------------------------------IQMVVLEGEY Mb0896c|M.bovis_AF2122/97 AQ----------------------IGSTLS--------------AANAAA Rv0872c|M.tuberculosis_H37Rv AQ----------------------IGSTLS--------------AANAAA MMAR_4149|M.marinum_M AS----------------------IGSAIS--------------QANVAA MUL_3318|M.ulcerans_Agy99 DG----------------------IGSPIT--------------AANAAA Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AN----------------------AGLSAVS-------------AAQVGA MLBr_01183|M.leprae_Br4923 EG----------------------LSAATV--------------ASNAAA MAV_4827|M.avium_104 AD-----------------------GATVEED------------AIDVTG Mb0896c|M.bovis_AF2122/97 LAP-------TTGVLAAGADEVSAAVASLFSGHAQAYQTLGTQAAAFHER Rv0872c|M.tuberculosis_H37Rv LAP-------TTGVLAAGADEVSAAVASLFSGHAQAYQTLGTQAAAFHER MMAR_4149|M.marinum_M AAP-------TMGALAAGADEVSAAVAAVFSGHAQAYQALGAQVAAFHDQ MUL_3318|M.ulcerans_Agy99 AIP-------TSAIAAAAADEISAAIAELFGNHAQQYQALSAQMARFHDQ Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu -----------------------VDGDGGSGGRTGLFSKLSRGG----DG MAB_4284c|M.abscessus_ATCC_199 VMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPS MLBr_01183|M.leprae_Br4923 AQL-------TTEIAPPAADDVSILLAHFFSGHGRQYQAHASQGATNHQD MAV_4827|M.avium_104 ADD---------AATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQ . Mb0896c|M.bovis_AF2122/97 FIQALSTAAG-----AYGSAEAANASPLQQALNVIN-------------A Rv0872c|M.tuberculosis_H37Rv FIQALSTAAG-----AYGSAEAANASPLQQALNVIN-------------A MMAR_4149|M.marinum_M LVTALDAAAG-----KYASAEVANASPLQAVLDVVN-------------A MUL_3318|M.ulcerans_Agy99 FVRSLSGAAQ-----TYARAEATGAAPLQPVLDLIN-------------G Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG TH_3810|M.thermoresistible__bu GDGGLGGNGG-----------HGGGTGIISLLSLAG-------------- MAB_4284c|M.abscessus_ATCC_199 LLSPRDNDFLS-----HNDTDFASHNPIASGNQVMS--------PSGNVD MLBr_01183|M.leprae_Br4923 LIQSLLTSSS-----AYAGTETANHDSL---------------------- MAV_4827|M.avium_104 LEAAALRDALAARRIDNVMLVSAFLAAAALAQNVGG---------AMGYE Mb0896c|M.bovis_AF2122/97 PTQTLLG------RPLIGNGTNGAPGTGQAGGPGG-------------LL Rv0872c|M.tuberculosis_H37Rv PTQTLLG------RPLIGNGTNGAPGTGQAGGPGG-------------LL MMAR_4149|M.marinum_M PAQALLG------RPLIGNGDDGVAGTGQSGGDGG-------------IL MUL_3318|M.ulcerans_Agy99 PTQALLG------RPLIGNGTSGALGTGQAGGDGG-------------LL Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT TH_3810|M.thermoresistible__bu ---------------NGGNGGNGYRTTDNNALDGG--------------- MAB_4284c|M.abscessus_ATCC_199 SFNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGS--------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 RTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAES-------------- Mb0896c|M.bovis_AF2122/97 YGN------------------------GGNGGSG---------------- Rv0872c|M.tuberculosis_H37Rv YGN------------------------GGNGGSG---------------- MMAR_4149|M.marinum_M YGN------------------------GGDGGSG---------------- MUL_3318|M.ulcerans_Agy99 IGNGTSGALGTGQAGGD---GGLLIGNGGAGGSG---------------- Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG---------------- Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG---------------- MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH TH_3810|M.thermoresistible__bu -----------------------------HGGNG---------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------NSGPIASGQG---------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------------------------YGDAAGQLS--------------- Mb0896c|M.bovis_AF2122/97 ---------------GVGQAGGAG-------------------------- Rv0872c|M.tuberculosis_H37Rv ---------------GVGQAGGAG-------------------------- MMAR_4149|M.marinum_M ---------------ASGQIGGTG-------------------------- MUL_3318|M.ulcerans_Agy99 ---------------AAGQAGGAGGAG----------------------- Mflv_5091|M.gilvum_PYR-GCK AVGAAGAAG------TVGTAGATGGTG---------------TGANGGAG Mvan_1264|M.vanbaalenii_PYR-1 AIGTAGVAG------AAGTAGATGGTG---------------VGGNGGAG MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS TH_3810|M.thermoresistible__bu -----------------GNVG----------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------STAVNGDVR-------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------AMVAGLEKLESLP------------------------ Mb0896c|M.bovis_AF2122/97 -----GSAGLIG---------------IGGTGGAGGAGAVGGVGGNGGWL Rv0872c|M.tuberculosis_H37Rv -----GSAGLIG---------------IGGTGGAGGAGAVGGVGGNGGWL MMAR_4149|M.marinum_M -----GSAGLIG---------------AGGTGGAGGLGAAGGAGGNGGWL MUL_3318|M.ulcerans_Agy99 -----GAAGLIG---------------SGGAGGIGGTGAAGGKGGN-AVL Mflv_5091|M.gilvum_PYR-GCK GVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGGQ- Mvan_1264|M.vanbaalenii_PYR-1 QAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGGQ- MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY TH_3810|M.thermoresistible__bu ------FFSLFN---------------LGGAGGWGGSGVDG--------- MAB_4284c|M.abscessus_ATCC_199 ------DSNIIN-------------ADHGSNVGVDQSQTRVGGDYTNVSG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----GGLLLVG-------------------SGVDVAPLKQVLQTTTFLD Mb0896c|M.bovis_AF2122/97 YGNGG-AGGLGGTGVAGVNGGMGAAGGAGGN------------------- Rv0872c|M.tuberculosis_H37Rv YGNGG-AGGLGGTGVAGVNGGMGAAGGAGGN------------------- MMAR_4149|M.marinum_M FGQGG-AGGIGGS---------GAAGGAGGNG------------------ MUL_3318|M.ulcerans_Agy99 FGAGG-NGGIGGTGAVG---GTGAVGGAGGNG------------------ Mflv_5091|M.gilvum_PYR-GCK -GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG----------- Mvan_1264|M.vanbaalenii_PYR-1 -GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG----------- MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA TH_3810|M.thermoresistible__bu ---------------------VDVVGGNP--------------------- MAB_4284c|M.abscessus_ATCC_199 HGSADIDKSVTVVDDHSQRNTTNINDSFNTDR------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VSVAEEPETALARGAALAAANAPLFASSTAAL------------------ Mb0896c|M.bovis_AF2122/97 ----AYLFGSGGAGGQGG-------------------------MGAAGAD Rv0872c|M.tuberculosis_H37Rv ----AYLFGSGGAGGQGG-------------------------MGAAGAD MMAR_4149|M.marinum_M ----GWLYGDGGAGGQGG-------------------------AAAESIN MUL_3318|M.ulcerans_Agy99 ----GFLFGHGGDGGTGG-------------------------TGASAAA Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV TH_3810|M.thermoresistible__bu ---------DGGTPG------------------------------AHGES MAB_4284c|M.abscessus_ATCC_199 ----STNIGSGNTTNTEIG------------------------SHNQANI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----AYAQDPGTGAVDQYS-----------------------LPDYLYV Mb0896c|M.bovis_AF2122/97 GVNPTPTGT----------------------------------------- Rv0872c|M.tuberculosis_H37Rv GVNPTPTGT----------------------------------------- MMAR_4149|M.marinum_M --DGSPGQG----------------------------------------- MUL_3318|M.ulcerans_Agy99 GANGGAGQTG---------------------------------------- Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD----------- Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN----------- MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP TH_3810|M.thermoresistible__bu HTPGVYTDR----------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GTSTSAGGS----------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PVDPEPGDDE---------------------------------------- Mb0896c|M.bovis_AF2122/97 ------------ADAGSTGTDQTLG-GNAIG------------------- Rv0872c|M.tuberculosis_H37Rv ------------ADAGSTGTDQTLG-GNAIG------------------- MMAR_4149|M.marinum_M ------------GNGGSAYLFGNGG-SGGQG------------------- MUL_3318|M.ulcerans_Agy99 ---------LAGTDGGTGGASGEGG-AGGKGGLLF--------------- Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG--------------- Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG--------------- MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ TH_3810|M.thermoresistible__bu --------------QGEDGEDGTGT------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------AAVGGNAGLAGNAGLAGNAG------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -----------LAYSAVGEEDAESPTVVIEKLFLP--------------- Mb0896c|M.bovis_AF2122/97 ----GNGGPGDAGDAMTSGGAG-GSGGNAVSTVNGDAVGGEGGK---GGE Rv0872c|M.tuberculosis_H37Rv ----GNGGPGDAGDAMTSGGAG-GSGGNAVSTVNGDAVGGEGGK---GGE MMAR_4149|M.marinum_M ----GTGLAGADGVNYSNGTAGPGAWGNNVTTSIGDANGGNGGSGADGGA MUL_3318|M.ulcerans_Agy99 ----GAGGEGGAGGTGGAGGTG-GAGGDGLAATTAGGTGGNAGDGGEGGA Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGGAGSTGGTGGTG-GTGGTGGTGGTG-GTGGTGGTGGTGGK Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGGAGSTGGTGGTG-GTGGTGGTGGTG-GTGGTGGTGGTGGK MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGGDGGTFVNAGAN-GNGGAGGAGGVSEGEGGTGGHGGDGGR TH_3810|M.thermoresistible__bu ----GIGGRGGNGGS-SSGTHPMAEDGEHVKALDG-RPGLDGGNGSHGGN MAB_4284c|M.abscessus_ATCC_199 --LAGNAGLAGNAGLAGNAGLA-GNAGLAGNAGLAGNAGLAGNAGLAGNA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------EDSEPRRRPVLLVGSGLAVVGISAVLALEIALAIGIRTTGTV Mb0896c|M.bovis_AF2122/97 GAYGGAGGAGGSA----ASIGN---AAIGGNG---------GAGGNAQAP Rv0872c|M.tuberculosis_H37Rv GAYGGAGGAGGSA----ASIGN---AAIGGNG---------GAGGNAQAP MMAR_4149|M.marinum_M GVTGGTGGVGGFA----NNEGSG--DANGGFG---------GTGGNGGAP MUL_3318|M.ulcerans_Agy99 GGNAGAGGAGGQG----GLFGNAGTTGAGGDG---------GNGGNGGLA Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGTG Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGTG MSMEG_0868|M.smegmatis_MC2_155 GGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNG TH_3810|M.thermoresistible__bu GGHGGRGGFLGIG-------------GSGGWG---------GHGGNGGDT MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAG-----LAGNAGLAGNAGLAG------NAGLAGNAGLA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ALQPTPNQHLIVP------------TEQAPAPP--------PVQASAPQP Mb0896c|M.bovis_AF2122/97 GGV--------------GGAGGEGGDAQVGTNSPSNAEA----------- Rv0872c|M.tuberculosis_H37Rv GGV--------------GGAGGEGGDAQVGTNSPSNAEA----------- MMAR_4149|M.marinum_M GAS--------------GGEGGTGG---VAIASGGNAYG----------- MUL_3318|M.ulcerans_Agy99 GN---------------GGAGGNGDASNPNGGTGGNAANPGAG------- Mflv_5091|M.gilvum_PYR-GCK GAG-----------DGTGGTGGTGG----TGGQGGQGGQGG--------- Mvan_1264|M.vanbaalenii_PYR-1 GAG-----------DGLGGTGGTGG----TGGFGGQGGQGG--------- MSMEG_0868|M.smegmatis_MC2_155 GAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVI TH_3810|M.thermoresistible__bu DAD--------------GGNGGDGG-------NGGSAGR----------- MAB_4284c|M.abscessus_ATCC_199 GNAG------------LAGNAGLAGNAGLAGNAGLAGNAAVAG------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 KISVP---------EPVAAPKPLSPPVAAPLPAAPPPAAPPLP------- Mb0896c|M.bovis_AF2122/97 -------GNGGSGGNGFDSFASGGTG-----------------------G Rv0872c|M.tuberculosis_H37Rv -------GNGGSGGNGFDSFASGGTG-----------------------G MMAR_4149|M.marinum_M -------GSGGTGGNGATG-ASGGTG-----------------------G MUL_3318|M.ulcerans_Agy99 -------GAGGAGGNGSRTGAPGTTGNTPTTAA----------------G Mflv_5091|M.gilvum_PYR-GCK --------TGGTGGQGG-LGGGGGTG-----------------------G Mvan_1264|M.vanbaalenii_PYR-1 --------TGGTGGQGG-LGGVGGTG-----------------------G MSMEG_0868|M.smegmatis_MC2_155 GSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDG TH_3810|M.thermoresistible__bu ---------GGTGGLRGVFGINGGNGR---------------------AG MAB_4284c|M.abscessus_ATCC_199 --------NAAVAGNAAVAGNAAVGGVLN-------------------TG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------EAPPIPAAPPVVPVPVVVPPVP-------------------VP Mb0896c|M.bovis_AF2122/97 AGGTGGA-------------GGRGG--LLIGDGGAG--------GAGGVG Rv0872c|M.tuberculosis_H37Rv AGGTGGA-------------GGRGG--LLIGDGGAG--------GAGGVG MMAR_4149|M.marinum_M TGGTGGD-------------GGHGG--LLIGNGGIG--------GIGGTG MUL_3318|M.ulcerans_Agy99 HGGKGGDGFNPATSGQDGGSGGKGGDAGQFGNGGNG--------GNGAAG Mflv_5091|M.gilvum_PYR-GCK QGGTGGT-------------GGQGGTGGTGGTGGTG--------GTGGAG Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGT-------------GGQGGTGGTGGTGGTG--------GTGGAG MSMEG_0868|M.smegmatis_MC2_155 HGGSGIN-------------GGHGGNGGQGTIEANGPSAVASGIGAGGNG TH_3810|M.thermoresistible__bu LGGRGXX----------------------XXGGGVG---------AAVRS MAB_4284c|M.abscessus_ATCC_199 VSGAIGG-------------SSHVGGAINESLGGSGS------VGGSTAV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 VPVRIPVP-------------DPVSPPQLLAPPRLSVP-----QPVQPPV Mb0896c|M.bovis_AF2122/97 GTGGSGAPGGGG-AGGDGGAANTDSAGSSRKAFGGDGGVGGDGASALGTG Rv0872c|M.tuberculosis_H37Rv GTGGSGAPGGGGGAGGDGGAANTDSAGSSRKAFGGDGGVGGDGASALGTG MMAR_4149|M.marinum_M GVGGIGGTGGDGGTGGVGGSALNTGSGVADANIGGDGGDAGTG----GDG MUL_3318|M.ulcerans_Agy99 DAAGSGHTGGNGGAGGGGGNAGQFGE-PGTGGSGGNGGKGGDGAAG-GNG Mflv_5091|M.gilvum_PYR-GCK GDGGLGGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGL Mvan_1264|M.vanbaalenii_PYR-1 GDGGLGGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGL MSMEG_0868|M.smegmatis_MC2_155 GDGIDGGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGN TH_3810|M.thermoresistible__bu GNGVFSGGGGTPSAGFGVPTTIQFPAGSCTSRAVSREGIMPSS------- MAB_4284c|M.abscessus_ATCC_199 GGGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTGV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 RVPQPPSPPQVGGTVPQSPPQHQTPPGEGTPPKPDGPGNYGGGHVPTPGA Mb0896c|M.bovis_AF2122/97 GE-----GGIGGQGGNGGAGGLLIGNGGAGGVGGTAGAG----------- Rv0872c|M.tuberculosis_H37Rv GE-----GGIGGQGGNGGAGGLLIGNGGAGGVGGTAGAG----------- MMAR_4149|M.marinum_M GT-----GGVGGVGGSGGAGGLLFGNGGDGGAGGDGGVG----------- MUL_3318|M.ulcerans_Agy99 GT-----GGIGGTGGIGGDG----RNGSTGAIGGNGGTG----------- Mflv_5091|M.gilvum_PYR-GCK FG----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGAT Mvan_1264|M.vanbaalenii_PYR-1 FG----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGAT MSMEG_0868|M.smegmatis_MC2_155 GGPSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTT TH_3810|M.thermoresistible__bu -------RAASARAGAACASSTSRSRRSFCCSRA---------------- MAB_4284c|M.abscessus_ATCC_199 GG----GVSTGVGVGSHVGGGISESLGGSGSVGGSTAVG----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GGSGGSGGGHVPTPGAGGSGGSGGGHVPTPGTGGPGGTG----------- Mb0896c|M.bovis_AF2122/97 --GTGGSGGAGGA------GGAGGGG----------------TNSGPGAA Rv0872c|M.tuberculosis_H37Rv --GTGGSGGAGGA------GGAGGGG----------------TNSGPGAA MMAR_4149|M.marinum_M --GTGGIGGAGGN------GGVGGDG----------------SSSGTGAG MUL_3318|M.ulcerans_Agy99 --GTGGTGGTGGKSLGNLPSGDGGVG----------------GNAGTGGN Mflv_5091|M.gilvum_PYR-GCK G-ATGAAGKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA Mvan_1264|M.vanbaalenii_PYR-1 G-ATGASGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA MSMEG_0868|M.smegmatis_MC2_155 GVATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --GGAHTGVGGGVNTGVGVGSHVGGG--------------ISESLGGSGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------GSGGGHVPTPGAGTPGGSG-------------------GGHLP Mb0896c|M.bovis_AF2122/97 -FGGNGNTGGNG----------------------GNGGAPGALG------ Rv0872c|M.tuberculosis_H37Rv -FGGNGNTGGNG----------------------GNGGAPGALG------ MMAR_4149|M.marinum_M GSGGDATDGGTG----------------------GDGGSGGGFGTG---- MUL_3318|M.ulcerans_Agy99 --GGNATDGGAG----------------------GKGGDGAAGGTG---- Mflv_5091|M.gilvum_PYR-GCK -NGANGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-ING Mvan_1264|M.vanbaalenii_PYR-1 -NGANGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-ING MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VGGSTAVGGGAHTS-------------------AINDALGGSGSVG---- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 FPGAGSTPGGSG------------------------GGHLPTPGAG---- Mb0896c|M.bovis_AF2122/97 GKGGSGG---------LIGRA--GSDGGVGAGGAGGA--------GGAGG Rv0872c|M.tuberculosis_H37Rv GKGGSGG---------LIGRA--GSDGGVGAGGAGGA--------GGAGG MMAR_4149|M.marinum_M GAGGTGGW--------LIGHS--GTNGIGGTGGAGGA--------GAVGG MUL_3318|M.ulcerans_Agy99 GNAGEFQS--------LLGISKGGDGGTGGDGGTGTP--------VGADG Mflv_5091|M.gilvum_PYR-GCK GAGGAGG-----------AGGEGGEGGDGGKGGAGAE--------GGAGG Mvan_1264|M.vanbaalenii_PYR-1 GAGGAGG-----------AGGEGGEGGAGGAGGDGSE--------GGAGG MSMEG_0868|M.smegmatis_MC2_155 GDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GSTAVGGG---------AHTSAINESMNSSINASHSS-------SMNESF MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------TPGGGLGGFGGGHAPAPG--------GGLGG Mb0896c|M.bovis_AF2122/97 TGGEGGTGGDGKTTDGNPGMGGSPGSAGQPGQPG------- Rv0872c|M.tuberculosis_H37Rv TGGEGGTGGDGKTTDGNPGMGGSPGSAGQPG---------- MMAR_4149|M.marinum_M DGGVGGDPGVGTTYNGISGHNGVQGGTGADGAAG------- MUL_3318|M.ulcerans_Agy99 LAGTGGAGGFGIFPGGQTGQNGTDSKAG------------- Mflv_5091|M.gilvum_PYR-GCK GGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 SGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 NGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu ----------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH--- MLBr_01183|M.leprae_Br4923 ----------------------------------------- MAV_4827|M.avium_104 GGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK---------