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KRVDVLDSAMSYIDVGQGDPIVFLHGNPTSSYLWRNVIPHLSDVGRCLAPDLIGMGASGTSPTFSYRFAD HVRYLDAWFEAVGITENVVLVVHDWGSALGFYRALRYPEQIAGIAYMDALVQPRTWAGFTDYEPLMRALR TEQGERMALAENVFVEKVVPGGVQRQLTEEEMAVYRTPYPTPQSRIPTLLWAREIPVEGEPADVQAMVQE YADFLSRSDIPKLLIVAEPGAILHEGGSELDFARSWPNQREVKVAGRHFLQEDSPDAIGAAVRAFVLDVR ERQDGADRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4113 | dhaA | - | 100% (290) | haloalkane dehalogenase DhaA |
| M. marinum M | MMAR_0112 | dhaA_1 | 9e-77 | 51.99% (277) | haloalkane dehalogenase DhaA_1 |
| M. marinum M | MMAR_2710 | - | 8e-25 | 28.06% (278) | haloalkane dehalogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2610 | dhaA | 3e-76 | 50.00% (288) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4848 | - | 2e-13 | 27.21% (294) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2579 | dhaA | 2e-76 | 50.35% (288) | haloalkane dehalogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-05 | 35.29% (85) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2289 | - | 2e-11 | 33.33% (117) | putative hydrolase, alpha/beta hydrolase fold |
| M. avium 104 | MAV_2130 | - | 6e-23 | 30.86% (269) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_6837 | - | 1e-70 | 49.28% (278) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_1615 | linB | 8e-80 | 52.13% (282) | POSSIBLE HALOALKANE DEHALOGENASE DHAA (1-CHLOROHEXANE |
| M. ulcerans Agy99 | MUL_3979 | dhaA | 1e-167 | 98.97% (290) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_2384 | - | 5e-19 | 31.69% (284) | haloalkane dehalogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4113|M.marinum_M -----------------------------MKRVDVLDS-----AMSYIDV
MUL_3979|M.ulcerans_Agy99 -----------------------------MKRVDVLDS-----AMSYIDV
Mb2610|M.bovis_AF2122/97 ------------------MTAFGVEPYGQPKYLEIAGK-----RMAYIDE
Rv2579|M.tuberculosis_H37Rv ------------------MTAFGVEPYGQPKYLEIAGK-----RMAYIDE
TH_1615|M.thermoresistible__bu --------------------MPGSKPYGEPRFREIKNK-----RMAYIDE
MSMEG_6837|M.smegmatis_MC2_155 --------------------MPGSEPYGRLQYREINGK-----RMAYIDE
MAV_2130|M.avium_104 MPVHAEELNMHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDE
Mvan_2384|M.vanbaalenii_PYR-1 ---------MDILRTPDERFADLPDFPFAPHYVEVDG-----LRMHYLDE
Mflv_4848|M.gilvum_PYR-GCK -------------------------MTVVHHRIDTVDG----HQVFYREA
MLBr_00862|M.leprae_Br4923 ------------------MPATQSIHKVPHQFVESPDG----VRLAIYQS
MAB_2289|M.abscessus_ATCC_1997 --MGVAAHQQIYRPVSGHGGAMSLGLEKHRRSVDIERG-----RISYLDI
: : : :
MMAR_4113|M.marinum_M G--QGDPIVFLHGNPTSSYLWRNVIPHLSDVG-RCLAPDLIGMGASG---
MUL_3979|M.ulcerans_Agy99 G--QGDPIVFLHGNPTSSYLWRNVIPHLSDVG-RCLAPDLIGMGASG---
Mb2610|M.bovis_AF2122/97 G--KGDAIVFQHGNPTSSYLWRNIMPHLEGLG-RLVACDLIGMGASDKLS
Rv2579|M.tuberculosis_H37Rv G--KGDAIVFQHGNPTSSYLWRNIMPHLEGLG-RLVACDLIGMGASDKLS
TH_1615|M.thermoresistible__bu G--EGDAIVFQHGNPTSSYLWRNVLPHLEGLG-RLVACDLIGMGGSEKLS
MSMEG_6837|M.smegmatis_MC2_155 A--RGDAIVFQHGNPSSSYLWRNVLPHTEGLG-RLVACDLIGMGASDKLD
MAV_2130|M.avium_104 GPIDGPPIVLLHGEPTWSYLYRTMITPLTDAGNRVLAPDLIGFGRSDK--
Mvan_2384|M.vanbaalenii_PYR-1 GPADGPVVLLLHGEPSWSYLYRRMIPVLVDAGLRAVAIDLVGFGRSDK--
Mflv_4848|M.gilvum_PYR-GCK GDPDAPVIVLLHGFPTSSFMFRNLIPELADRY-RVIAPDYLGFGYSDAP-
MLBr_00862|M.leprae_Br4923 GQPEGPAIVLVHGFPDSHVLWDGVVPLLAKRF-RIVRYDNRGVGQSS--V
MAB_2289|M.abscessus_ATCC_1997 G--AGSPTVFVHGVLTNSLLWRDVVTAVAATGRRCIALDLPGHGHSP--V
. . :: ** :: ::. * : * * * *
MMAR_4113|M.marinum_M TSPTFSYRFADHVRYLDAWFEAVGITENVVLVVHDWGSALGFYRALRY--
MUL_3979|M.ulcerans_Agy99 TSPTFSYQFADHVRYLDAWFEAVGITENVVLVVHDWGSALGFYRALRY--
Mb2610|M.bovis_AF2122/97 PSGPDRYSYGEQRDFLFALWDTLDLGDHVVLVLHDWGSALGFDWANQH--
Rv2579|M.tuberculosis_H37Rv PSGPDRYSYGEQRDFLFALWDALDLGDHVVLVLHDWGSALGFDWANQH--
TH_1615|M.thermoresistible__bu PSGPDRYHYGEHRDYLFALWEELELGDRVVLVLHDWGSVLGFDWANHH--
MSMEG_6837|M.smegmatis_MC2_155 GSGPDSYHYHENRDYLFALWDALDLGDRVTLVLHDWGGALGFDWANRH--
MAV_2130|M.avium_104 PSRIEDYSYQRHVDWVVSWFEHLNLSD-VTLFVQDWGSLIGLRIAAEQ--
Mvan_2384|M.vanbaalenii_PYR-1 PTRREDYTYQAHVDWTWAAIEAIGLTG-ITLVCQDWGGLIGLRLVGEH--
Mflv_4848|M.gilvum_PYR-GCK TVEDFDYTFDALTDSVAGLLTQLGIRR-YAIYVQDYGAPVGWRLALRD--
MLBr_00862|M.leprae_Br4923 PKPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGA
MAB_2289|M.abscessus_ATCC_1997 PADGIDVTLSGLAQLIAEFLDSIGIDE-FDLVANDTGGAVAQIMVARQ--
: : :* *. .
MMAR_4113|M.marinum_M PEQIAGIAYMDAL-------------------------------VQPRTW
MUL_3979|M.ulcerans_Agy99 PEQIAGIAYMDAP-------------------------------VQPRTW
Mb2610|M.bovis_AF2122/97 RDRVQGIAFMEAI-------------------------------VTPMTW
Rv2579|M.tuberculosis_H37Rv RDRVQGIAFMEAI-------------------------------VTPMTW
TH_1615|M.thermoresistible__bu RDRVQGIAHMESI-------------------------------VTPLTW
MSMEG_6837|M.smegmatis_MC2_155 RDRVAGIVHMETV-------------------------------SVPMEW
MAV_2130|M.avium_104 PDRVGRLVVANGF-------------------------------LPTAQR
Mvan_2384|M.vanbaalenii_PYR-1 PDRFARVVAANTT-------------------------------LPTGDQ
Mflv_4848|M.gilvum_PYR-GCK PAAITAIITQNGN-------------------------------GYNDGF
MLBr_00862|M.leprae_Br4923 SDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVL
MAB_2289|M.abscessus_ATCC_1997 PDRIRTLALTNCDTEG---------------------------HVPPKLF
. . .
MMAR_4113|M.marinum_M AGFTDYEP-LMRALRTEQGERMALAENVFVEKVVPGGVQRQLTEEEMAVY
MUL_3979|M.ulcerans_Agy99 AGFTDYEP-LMRALRTEQGERMALAENVFVEKVVPGGVQRQLTEEEMAVY
Mb2610|M.bovis_AF2122/97 ADWPPAVRGVFQGFRSPQGEPMALEHNIFVERVLPGAILRQLSDEEMNHY
Rv2579|M.tuberculosis_H37Rv ADWPPAVRGVFQGFRSPQGEPMALEHNIFVERVLPGAILRQLSDEEMNHY
TH_1615|M.thermoresistible__bu ADWEDPARSVFQGLRTPEGERMVLEENIFVEAMLPRGVHRTLSDEEMAHY
MSMEG_6837|M.smegmatis_MC2_155 DDFPDEVAQMFRGLRSPQGEEMVLENNAFIEGVLPSIVMRTLSEEEMIHY
MAV_2130|M.avium_104 RTPPAFYAWRAFARYSP---------VLPAGRIVSVGTVRRVSSKVRAGY
Mvan_2384|M.vanbaalenii_PYR-1 RPGEAFLAWQRFSQETP---------DFAVGHIVNGGCVSTLAPEVIAAY
Mflv_4848|M.gilvum_PYR-GCK VAEGWQPAWDYQREQTP-------ETEAALRGILTFETTRMQYTAGVPDP
MLBr_00862|M.leprae_Br4923 FSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTY
MAB_2289|M.abscessus_ATCC_1997 KPVVALARPPLMALIGP---------RLFARRKVLRALLGAGYRKPGRLP
MMAR_4113|M.marinum_M RTPYPTP-QSRIPTLLWAR-------------------------------
MUL_3979|M.ulcerans_Agy99 RKPYPTP-QSRIPTLLWAR-------------------------------
Mb2610|M.bovis_AF2122/97 RRPFVNGGEDRRPTLSWPR-------------------------------
Rv2579|M.tuberculosis_H37Rv RRPFVNGGEDRRPTLSWPR-------------------------------
TH_1615|M.thermoresistible__bu REPFRDRGEGRRPTLTWPR-------------------------------
MSMEG_6837|M.smegmatis_MC2_155 RRPFLNAGEDRRPTLSWPR-------------------------------
MAV_2130|M.avium_104 DAPFPDK-TYQAGARAFPQ-------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 DAPFPDD-SYKAGARQFPT-------------------------------
Mflv_4848|M.gilvum_PYR-GCK SVVSPDTWHHDFALLSRPGN------------------------------
MLBr_00862|M.leprae_Br4923 PANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRL
MAB_2289|M.abscessus_ATCC_1997 DSIVESYGQPVFGTAESSR-------------------------------
.
MMAR_4113|M.marinum_M --------EIPVEGEPADVQAMVQEYADFLSRSDIPKLLIVAEPGAILHE
MUL_3979|M.ulcerans_Agy99 --------EIPVEGEPADVQAMVQEYADFLSRSDIPKLLIVAEPGAILHE
Mb2610|M.bovis_AF2122/97 --------NLPIDGEPAEVVALVNEYRSWLEETDMPKLFINAEPGAIITG
Rv2579|M.tuberculosis_H37Rv --------NLPIDGEPAEVVALVNEYRSWLEETDMPKLFINAEPGAIITG
TH_1615|M.thermoresistible__bu --------NVPIDGEPADVAAIVADYAVWLAEGDVPKLFVNAEPGAIVRG
MSMEG_6837|M.smegmatis_MC2_155 --------DVPLAGEPAEVVAVIEDFGEWLATSDIPKLFIRADPGVIQGK
MAV_2130|M.avium_104 --------LVPTSPADPAIPANRKAWEALG-RWEKPFLAIFGARDPILGH
Mvan_2384|M.vanbaalenii_PYR-1 --------LVPTSPDDPAAPANRAAWEVLR-TFDRPFLCAFSDSDPITRG
Mflv_4848|M.gilvum_PYR-GCK -----DRIQLKLFLDYSTNPKIYPALHDYLRASGVPLLAVWGDKDPFFGP
MLBr_00862|M.leprae_Br4923 WRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDT
MAB_2289|M.abscessus_ATCC_1997 --------FLSKMLRAMHTRDLEAARAGLVTFTKPTLIAWGLGDYFFPLK
. .
MMAR_4113|M.marinum_M GG-SELDFARS----------------------------WPNQREVKVA-
MUL_3979|M.ulcerans_Agy99 GG-SELDFARS----------------------------WPNQREVKVA-
Mb2610|M.bovis_AF2122/97 ---RIRDYVRS----------------------------WPNQTEITVP-
Rv2579|M.tuberculosis_H37Rv ---RIRDYVRS----------------------------WPNQTEITVP-
TH_1615|M.thermoresistible__bu ---RVRDFVRS----------------------------WPNQTEITVA-
MSMEG_6837|M.smegmatis_MC2_155 Q--RILDIVRS----------------------------WPNQTEITVP-
MAV_2130|M.avium_104 ADSPLIKHIPG----------------------------AAGQPHARIN-
Mvan_2384|M.vanbaalenii_PYR-1 ADAPLRKFIPG----------------------------AQGRPEVTIAG
Mflv_4848|M.gilvum_PYR-GCK DG--ARAFAKD----------------------------AVDS-EIHLID
MLBr_00862|M.leprae_Br4923 FGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVAS
MAB_2289|M.abscessus_ATCC_1997 YGQRLAELFGG------------------------------PVTFETVPD
:
MMAR_4113|M.marinum_M GRHFLQEDSPDAIGAAVRAFVLDVRERQDGADRA----------------
MUL_3979|M.ulcerans_Agy99 GRHFLQEDSPDAIGAAVRAFVLDVRERQDGADRA----------------
Mb2610|M.bovis_AF2122/97 GVHFVQEDSPEEIGAAIAQFVRQLRSAAGV--------------------
Rv2579|M.tuberculosis_H37Rv GVHFVQEDSPEEIGAAIAQFVRRLRSAAGV--------------------
TH_1615|M.thermoresistible__bu GRHYIQEDSPDEIGAAIADFVRKLRG------------------------
MSMEG_6837|M.smegmatis_MC2_155 GTHFLQEDSADQIGEAIASFVREIRAGDNLHREAAPEMNSAS--------
MAV_2130|M.avium_104 ASHFIQEDRGPELAERILSWQQALL-------------------------
Mvan_2384|M.vanbaalenii_PYR-1 GGHFLQEDKGPELAAVVVDFIAANPV------------------------
Mflv_4848|M.gilvum_PYR-GCK GGHFLLESELTRVANLIRDFLERRL-------------------------
MLBr_00862|M.leprae_Br4923 GGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTP
MAB_2289|M.abscessus_ATCC_1997 GRLYFPDEDADRLLPLLYRHWHSAGRQESSTEVGS---------------
. :
MMAR_4113|M.marinum_M --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
Mb2610|M.bovis_AF2122/97 --------------------------------------------------
Rv2579|M.tuberculosis_H37Rv --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00862|M.leprae_Br4923 PEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSL
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4113|M.marinum_M --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
Mb2610|M.bovis_AF2122/97 --------------------------------------------------
Rv2579|M.tuberculosis_H37Rv --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPT
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4113|M.marinum_M --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
Mb2610|M.bovis_AF2122/97 --------------------------------------------------
Rv2579|M.tuberculosis_H37Rv --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYA
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4113|M.marinum_M ---------------------
MUL_3979|M.ulcerans_Agy99 ---------------------
Mb2610|M.bovis_AF2122/97 ---------------------
Rv2579|M.tuberculosis_H37Rv ---------------------
TH_1615|M.thermoresistible__bu ---------------------
MSMEG_6837|M.smegmatis_MC2_155 ---------------------
MAV_2130|M.avium_104 ---------------------
Mvan_2384|M.vanbaalenii_PYR-1 ---------------------
Mflv_4848|M.gilvum_PYR-GCK ---------------------
MLBr_00862|M.leprae_Br4923 LYGISRVLPQVLRSTARIRVI
MAB_2289|M.abscessus_ATCC_1997 ---------------------