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VPAGAPPIDCRYGLPGHYARVQAFSPTHLEAPMTEIDPTPLTKRRLAVDGKQMAYHESGEGRSVVFLHGN PTSSYLWRNIIPHVSDRARCIAPDLIGQGDSDKLDDTGPGSYRFVEHRHYLDGLLDQLDLGDDVVLVIHD WGSALGFDWANRHRERIGGIAFMEAIVRPVTWAEWPESAAGIFRGFRSDAGEQMVIDKNLFVEAVLPGSI LRGLTPAEHDEYRRPFVEPRHRRPTLSWPREIPIEGEPADVHQIASDYAQWLPTADFPKLFINAEPGAIL TGPQREFCRSWTNLTEVTVPGSHFIQEDSPHEIGQAIADWLSSLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0112 | dhaA_1 | - | 100% (325) | haloalkane dehalogenase DhaA_1 |
| M. marinum M | MMAR_4113 | dhaA | 1e-76 | 51.99% (277) | haloalkane dehalogenase DhaA |
| M. marinum M | MMAR_3472 | - | 9e-20 | 27.62% (315) | haloalkane dehalogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2610 | dhaA | 1e-102 | 61.07% (280) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4848 | - | 2e-12 | 38.26% (115) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2579 | dhaA | 1e-102 | 61.07% (280) | haloalkane dehalogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-08 | 29.25% (106) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4300 | - | 7e-09 | 31.58% (114) | putative hydrolase, alpha/beta fold |
| M. avium 104 | MAV_2130 | - | 1e-16 | 27.76% (281) | haloalkane dehalogenase |
| M. smegmatis MC2 155 | MSMEG_6837 | - | 7e-90 | 53.57% (280) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_1615 | linB | 4e-96 | 57.55% (278) | POSSIBLE HALOALKANE DEHALOGENASE DHAA (1-CHLOROHEXANE |
| M. ulcerans Agy99 | MUL_3979 | dhaA | 4e-76 | 51.62% (277) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_2384 | - | 3e-18 | 26.62% (293) | haloalkane dehalogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2610|M.bovis_AF2122/97 ----------MTAFGVEP-----YGQP-----------------------
Rv2579|M.tuberculosis_H37Rv ----------MTAFGVEP-----YGQP-----------------------
TH_1615|M.thermoresistible__bu ------------MPGSKP-----YGEP-----------------------
MSMEG_6837|M.smegmatis_MC2_155 ------------MPGSEP-----YGRL-----------------------
MMAR_0112|M.marinum_M ------------MPAGAPPIDCRYGLPGHYARVQAFSPTHLEAPMTEIDP
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 MPVHAEELNMHVLRTPDSRFENLEDYP-----------------------
Mvan_2384|M.vanbaalenii_PYR-1 ---------MDILRTPDERFADLPDFP-----------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 ---------------MDAELEEWKAAG-----------------------
MLBr_00862|M.leprae_Br4923 ----------------MPATQSIHKVP-----------------------
Mb2610|M.bovis_AF2122/97 -----KYLEIAGK-----RMAYIDEG--KGDAIVFQHGNPTSSYLWRNIM
Rv2579|M.tuberculosis_H37Rv -----KYLEIAGK-----RMAYIDEG--KGDAIVFQHGNPTSSYLWRNIM
TH_1615|M.thermoresistible__bu -----RFREIKNK-----RMAYIDEG--EGDAIVFQHGNPTSSYLWRNVL
MSMEG_6837|M.smegmatis_MC2_155 -----QYREINGK-----RMAYIDEA--RGDAIVFQHGNPSSSYLWRNVL
MMAR_0112|M.marinum_M TPLTKRRLAVDGK-----QMAYHESG--EGRSVVFLHGNPTSSYLWRNII
MUL_3979|M.ulcerans_Agy99 ----MKRVDVLDS-----AMSYIDVG--QGDPIVFLHGNPTSSYLWRNVI
MAV_2130|M.avium_104 --FVAHYLDVTARDTRPLRMHYLDEGPIDGPPIVLLHGEPTWSYLYRTMI
Mvan_2384|M.vanbaalenii_PYR-1 --FAPHYVEVDG-----LRMHYLDEGPADGPVVLLLHGEPSWSYLYRRMI
Mflv_4848|M.gilvum_PYR-GCK MTVVHHRIDTVDG----HQVFYREAGDPDAPVIVLLHGFPTSSFMFRNLI
MAB_4300|M.abscessus_ATCC_1997 -----HYFDYLGF-----DIFYRVEG--SGPPLLLIHGYPFNSWDWALIW
MLBr_00862|M.leprae_Br4923 ----HQFVESPDG----VRLAIYQSGQPEGPAIVLVHGFPDSHVLWDGVV
: : . . ::: ** * : :
Mb2610|M.bovis_AF2122/97 PHLEGLG-RLVACDLIGMGASDKLSPSGPDRYSYGEQRDFLFALWDTLDL
Rv2579|M.tuberculosis_H37Rv PHLEGLG-RLVACDLIGMGASDKLSPSGPDRYSYGEQRDFLFALWDALDL
TH_1615|M.thermoresistible__bu PHLEGLG-RLVACDLIGMGGSEKLSPSGPDRYHYGEHRDYLFALWEELEL
MSMEG_6837|M.smegmatis_MC2_155 PHTEGLG-RLVACDLIGMGASDKLDGSGPDSYHYHENRDYLFALWDALDL
MMAR_0112|M.marinum_M PHVSDRA-RCIAPDLIGQGDSDKLDDTGPGSYRFVEHRHYLDGLLDQLDL
MUL_3979|M.ulcerans_Agy99 PHLSDVG-RCLAPDLIGMGASG---TSPTFSYQFADHVRYLDAWFEAVGI
MAV_2130|M.avium_104 TPLTDAGNRVLAPDLIGFGRSDK--PSRIEDYSYQRHVDWVVSWFEHLNL
Mvan_2384|M.vanbaalenii_PYR-1 PVLVDAGLRAVAIDLVGFGRSDK--PTRREDYTYQAHVDWTWAAIEAIGL
Mflv_4848|M.gilvum_PYR-GCK PELADRY-RVIAPDYLGFGYSDAP-TVEDFDYTFDALTDSVAGLLTQLGI
MAB_4300|M.abscessus_ATCC_1997 PTLVERF-TVIAPDMIGMGFSDK---PVQYGYSVLDHADMHEALLSYLGI
MLBr_00862|M.leprae_Br4923 PLLAKRF-RIVRYDNRGVGQSSVP--KPVSAYTMTRFADDFAAVIDELSP
. : * * * * * . :
Mb2610|M.bovis_AF2122/97 GDHVVLVLHDWGSALGFDWANQH--RDRVQGIAFMEAIVTPMTWADWPPA
Rv2579|M.tuberculosis_H37Rv GDHVVLVLHDWGSALGFDWANQH--RDRVQGIAFMEAIVTPMTWADWPPA
TH_1615|M.thermoresistible__bu GDRVVLVLHDWGSVLGFDWANHH--RDRVQGIAHMESIVTPLTWADWEDP
MSMEG_6837|M.smegmatis_MC2_155 GDRVTLVLHDWGGALGFDWANRH--RDRVAGIVHMETVSVPMEWDDFPDE
MMAR_0112|M.marinum_M GDDVVLVIHDWGSALGFDWANRH--RERIGGIAFMEAIVRPVTWAEWPES
MUL_3979|M.ulcerans_Agy99 TENVVLVVHDWGSALGFYRALRY--PEQIAGIAYMDAPVQPRTWAGFTDY
MAV_2130|M.avium_104 SD-VTLFVQDWGSLIGLRIAAEQ--PDRVGRLVVANGFLP--TAQRRTPP
Mvan_2384|M.vanbaalenii_PYR-1 TG-ITLVCQDWGGLIGLRLVGEH--PDRFARVVAANTTLP--TGDQRPGE
Mflv_4848|M.gilvum_PYR-GCK RR-YAIYVQDYGAPVGWRLALRD--PAAITAIITQNGNGYNDGFVAEGWQ
MAB_4300|M.abscessus_ATCC_1997 ER-FHLLTHDLGNSVGQEMLARF--EFEQQSRGRVPIDSVTWLNGGLFIE
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
: :* * .
Mb2610|M.bovis_AF2122/97 VRGVFQGF-------------------------------RSPQGEPMALE
Rv2579|M.tuberculosis_H37Rv VRGVFQGF-------------------------------RSPQGEPMALE
TH_1615|M.thermoresistible__bu ARSVFQGL-------------------------------RTPEGERMVLE
MSMEG_6837|M.smegmatis_MC2_155 VAQMFRGL-------------------------------RSPQGEEMVLE
MMAR_0112|M.marinum_M AAGIFRGF-------------------------------RSDAGEQMVID
MUL_3979|M.ulcerans_Agy99 EP-LMRAL-------------------------------RTEQGERMALA
MAV_2130|M.avium_104 AFYAWRAF-------------------------------ARYS-------
Mvan_2384|M.vanbaalenii_PYR-1 AFLAWQRF-------------------------------SQET-------
Mflv_4848|M.gilvum_PYR-GCK PAWDYQRE-------------------------------QTPET------
MAB_4300|M.abscessus_ATCC_1997 AYRPRIAQ-------------------------------TLMSRTPLGDL
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb2610|M.bovis_AF2122/97 HNIFVERVLPGAILR----------------------------------Q
Rv2579|M.tuberculosis_H37Rv HNIFVERVLPGAILR----------------------------------Q
TH_1615|M.thermoresistible__bu ENIFVEAMLPRGVHR----------------------------------T
MSMEG_6837|M.smegmatis_MC2_155 NNAFIEGVLPSIVMR----------------------------------T
MMAR_0112|M.marinum_M KNLFVEAVLPGSILR----------------------------------G
MUL_3979|M.ulcerans_Agy99 ENVFVEKVVPGGVQR----------------------------------Q
MAV_2130|M.avium_104 PVLPAGRIVSVGTVR----------------------------------R
Mvan_2384|M.vanbaalenii_PYR-1 PDFAVGHIVNGGCVS----------------------------------T
Mflv_4848|M.gilvum_PYR-GCK -EAALRGILTFETTR----------------------------------M
MAB_4300|M.abscessus_ATCC_1997 VSRFQGTPVTRRIMD----------------------------------A
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb2610|M.bovis_AF2122/97 LSDEEMNHYRRPFVNGGEDRRPTLSWPR-----NLPIDGEPAEVVALVNE
Rv2579|M.tuberculosis_H37Rv LSDEEMNHYRRPFVNGGEDRRPTLSWPR-----NLPIDGEPAEVVALVNE
TH_1615|M.thermoresistible__bu LSDEEMAHYREPFRDRGEGRRPTLTWPR-----NVPIDGEPADVAAIVAD
MSMEG_6837|M.smegmatis_MC2_155 LSEEEMIHYRRPFLNAGEDRRPTLSWPR-----DVPLAGEPAEVVAVIED
MMAR_0112|M.marinum_M LTPAEHDEYRRPFVEP-RHRRPTLSWPR-----EIPIEGEPADVHQIASD
MUL_3979|M.ulcerans_Agy99 LTEEEMAVYRKPYPTP-QSRIPTLLWAR-----EIPVEGEPADVQAMVQE
MAV_2130|M.avium_104 VSSKVRAGYDAPFPDK-TYQAGARAFPQ-----LVPTSPADPAIPANRKA
Mvan_2384|M.vanbaalenii_PYR-1 LAPEVIAAYDAPFPDD-SYKAGARQFPT-----LVPTSPDDPAAPANRAA
Mflv_4848|M.gilvum_PYR-GCK QYTAGVPDPSVVSPDTWHHDFALLSRPGNDRI-QLKLFLDYSTNPKIYPA
MAB_4300|M.abscessus_ATCC_1997 AVSEMFGPDTKPSPRLLSLFQQVLEYNDGARV-THQVGRFINDRYDNRSR
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb2610|M.bovis_AF2122/97 YRSWLEETDMPKLFINAEPG---AIITG---RIRDYVRSWPNQTEITVP-
Rv2579|M.tuberculosis_H37Rv YRSWLEETDMPKLFINAEPG---AIITG---RIRDYVRSWPNQTEITVP-
TH_1615|M.thermoresistible__bu YAVWLAEGDVPKLFVNAEPG---AIVRG---RVRDFVRSWPNQTEITVA-
MSMEG_6837|M.smegmatis_MC2_155 FGEWLATSDIPKLFIRADPG---VIQGKQ--RILDIVRSWPNQTEITVP-
MMAR_0112|M.marinum_M YAQWLPTADFPKLFINAEPG---AILTG---PQREFCRSWTNLTEVTVP-
MUL_3979|M.ulcerans_Agy99 YADFLSRSDIPKLLIVAEPG---AILHEGG-SELDFARSWPNQREVKVA-
MAV_2130|M.avium_104 WEALG-RWEKPFLAIFGARD---PILGHADSPLIKHIPGAAGQPHARIN-
Mvan_2384|M.vanbaalenii_PYR-1 WEVLR-TFDRPFLCAFSDSD---PITRGADAPLRKFIPGAQGRPEVTIAG
Mflv_4848|M.gilvum_PYR-GCK LHDYLRASGVPLLAVWGDKD---PFFGPD--GARAFAKDAVDS-EIHLID
MAB_4300|M.abscessus_ATCC_1997 WVRAMRETAVPMRMIDGPID---PNSGLH--MAERYLEVIHDPDVVLLDD
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
. . . :
Mb2610|M.bovis_AF2122/97 -GVHFVQEDSPEEIGAAIAQFVRQLRSAAGV-------------------
Rv2579|M.tuberculosis_H37Rv -GVHFVQEDSPEEIGAAIAQFVRRLRSAAGV-------------------
TH_1615|M.thermoresistible__bu -GRHYIQEDSPDEIGAAIADFVRKLRG-----------------------
MSMEG_6837|M.smegmatis_MC2_155 -GTHFLQEDSADQIGEAIASFVREIRAGDNLHREAAPEMNSAS-------
MMAR_0112|M.marinum_M -GSHFIQEDSPHEIGQAIADWLSSLG------------------------
MUL_3979|M.ulcerans_Agy99 -GRHFLQEDSPDAIGAAVRAFVLDVRERQDGADRA---------------
MAV_2130|M.avium_104 -ASHFIQEDRGPELAERILSWQQALL------------------------
Mvan_2384|M.vanbaalenii_PYR-1 -GGHFLQEDKGPELAAVVVDFIAANPV-----------------------
Mflv_4848|M.gilvum_PYR-GCK -GGHFLLESELTRVANLIRDFLERRL------------------------
MAB_4300|M.abscessus_ATCC_1997 NIGHWPQIEAPEAVLTHFLEHIDRITP-----------------------
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
. .
Mb2610|M.bovis_AF2122/97 --------------------------------------------------
Rv2579|M.tuberculosis_H37Rv --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0112|M.marinum_M --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQR
Mb2610|M.bovis_AF2122/97 --------------------------------------------------
Rv2579|M.tuberculosis_H37Rv --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0112|M.marinum_M --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVG
Mb2610|M.bovis_AF2122/97 --------------------------------------------------
Rv2579|M.tuberculosis_H37Rv --------------------------------------------------
TH_1615|M.thermoresistible__bu --------------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0112|M.marinum_M --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPD
Mb2610|M.bovis_AF2122/97 ----------------------------------------------
Rv2579|M.tuberculosis_H37Rv ----------------------------------------------
TH_1615|M.thermoresistible__bu ----------------------------------------------
MSMEG_6837|M.smegmatis_MC2_155 ----------------------------------------------
MMAR_0112|M.marinum_M ----------------------------------------------
MUL_3979|M.ulcerans_Agy99 ----------------------------------------------
MAV_2130|M.avium_104 ----------------------------------------------
Mvan_2384|M.vanbaalenii_PYR-1 ----------------------------------------------
Mflv_4848|M.gilvum_PYR-GCK ----------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 ----------------------------------------------
MLBr_00862|M.leprae_Br4923 KVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI