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AVTEWTIGAVLDAIAEVVPDRPMTVCGPRRTSFAEAAQRTSRLASYLNKQGFGAHRARETLQRWECGQDR VALIMHNDLYPDMVIGCLKARVVPVNVNHHYSPREIAELLEYVRPRGIIYHRALGARFADLLPAAGADLL VSIDDGSGAAELPGAVSLDEVVTAGAPNYRPTGSPDDLIMMCTGGTTGRPKGVLWRQGDMYVASMVGADH ANVDEIHQKVRLGGSPWFAVSPLMHAAGLWTAFSGFLSGFPVVLYDDRAKLDVRSVWATAEREKVGMVTM VGDAYAGPLVAELSAHPYDLSALQAIGTGGAATNPKYKRALMERLPHVTIIEGYGSSETGNMAFGHSRNR MASETFAMRVGGAVASADRSSFLQPGTAEIGWAARMGRIPLGYFNDPEATRRTFPEIEGHRVVIPGDRAT IENDGTIRLLGRDSLVVNTGGEKVFVEEVEEVLRGHPDIADALVVGRASQRWGQEVVALVAARPGVDLAG SERALYALCTAKLAHFKAPKAFIFVSHIQRLGNGKPNYRWAKQAAAQQLPVGGSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4013 | - | - | 100% (546) | fatty-acid-CoA ligase |
| M. marinum M | MMAR_2064 | - | e-113 | 42.75% (545) | fatty-acid-CoA ligase |
| M. marinum M | MMAR_4007 | fadD19_2 | e-109 | 42.20% (545) | fatty-acid-CoA ligase FadD19_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3544c | fadD19 | 9e-75 | 34.32% (539) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4349 | - | 0.0 | 63.84% (542) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3515c | fadD19 | 1e-74 | 34.32% (539) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 5e-23 | 26.28% (487) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4163c | - | 2e-75 | 32.36% (547) | acyl-CoA synthetase |
| M. avium 104 | MAV_1592 | - | 0.0 | 67.10% (538) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_2231 | - | 0.0 | 63.94% (538) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4377 | - | 0.0 | 66.11% (543) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3870 | fadD19_2 | 1e-107 | 41.83% (545) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1995 | - | 0.0 | 65.13% (542) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3544c|M.bovis_AF2122/97 -----------MAVALNIADLAEHAIDAVPDRVAVICGDEQLTYAQLEDK
Rv3515c|M.tuberculosis_H37Rv -----------MAVALNIADLAEHAIDAVPDRVAVICGDEQLTYAQLEDK
MAB_4163c|M.abscessus_ATCC_199 -------------MALNIADLIEHAIDTMPDRVAIISGDRKLTYAELEEQ
Mflv_4349|M.gilvum_PYR-GCK ------------MPEWTIGGVVDAIAEAIPDRLMTVCGSRRSTYAETAER
Mvan_1995|M.vanbaalenii_PYR-1 ------------MGEWTIGGVVDAIAEAVPDRLMTVCGERRSTYRQTADR
TH_4377|M.thermoresistible__bu ------------MGEWTIGAVLDAIAEAVPDRPMTVCGGRRSTFAETADR
MSMEG_2231|M.smegmatis_MC2_155 ------------MPEWTIGGVVDAIAEAVPDREMTVCGARRTTFAQGADR
MAV_1592|M.avium_104 ------------MSEWTIGAVLDEIADVIPDRTMTVCGDRRSTFAESADR
MMAR_4013|M.marinum_M ----------MAVTEWTIGAVLDAIAEVVPDRPMTVCGPRRTSFAEAAQR
MUL_3870|M.ulcerans_Agy99 -----------MTTQFTVPAVASAVTAAIGDRELVVQGDRRHTYRQIHQR
MLBr_02661|M.leprae_Br4923 MKSESITSSRAPVEQIDARLTGQFESPSIASLVEAAAIRNPSAPALVVTD
. : . . :
Mb3544c|M.bovis_AF2122/97 ANRLAHHLIDQGVQKD-------------DKVGLYCRNRIEIVIAMLGIV
Rv3515c|M.tuberculosis_H37Rv ANRLAHHLIDQGVQKD-------------DKVGLYCRNRIEIVIAMLGIV
MAB_4163c|M.abscessus_ATCC_199 SNRLGHYLQSQGVGPG-------------DKVGLYCRNGIEIVIALTAIV
Mflv_4349|M.gilvum_PYR-GCK TRRVANFLSANGIGAHQERDTIDGWQCGQDRVALIMHN-DLYPDMVIGAL
Mvan_1995|M.vanbaalenii_PYR-1 TRRFANFLSANGIGAHQERDALQGWECGQDRVALIMHN-DLYPDMVIGSL
TH_4377|M.thermoresistible__bu TRRLANFLAAHGFGAHRERAELANWECGQDRVALIMHN-DLYPDMVIGCL
MSMEG_2231|M.smegmatis_MC2_155 TRRIANFLAGQGLGAHRERRELNRWECGQDRVALIMHN-DQYPDLVIGCL
MAV_1592|M.avium_104 TRRLANFLSGNGLGVHRERAVLQNWECGQDRVALVMHN-DLYPDMVVGCL
MMAR_4013|M.marinum_M TSRLASYLNKQGFGAHRARETLQRWECGQDRVALIMHN-DLYPDMVIGCL
MUL_3870|M.ulcerans_Agy99 SNRLASYLHSQGLGCHTERSELAGHEVGQNLLGIYAYNGNEFVEALFGSF
MLBr_02661|M.leprae_Br4923 NRIVVSYRDLLRLVDDLTVQLALGGLLPGDRVALCAASNIEFVVGLLAAS
. . . : :.: . : .
Mb3544c|M.bovis_AF2122/97 KAGAILVNVNFRYVEGELRYLFDNSDMVALVHERRYADRVANVLPDTPHV
Rv3515c|M.tuberculosis_H37Rv KAGAILVNVNFRYVEGELRYLFDNSDMVALVHERRYADRVANVLPDTPHV
MAB_4163c|M.abscessus_ATCC_199 KIRAISVNVNYRYVEAELHYLFENSDMAALVHERRYSDKVANVLPSTPNV
Mflv_4349|M.gilvum_PYR-GCK KARAVPVNVNFNYTPREVDELLAYLRPRAVIFHRSLGAKFADVLPRT-GV
Mvan_1995|M.vanbaalenii_PYR-1 KARAVPVNVNFNYTPREVDELLSYLRPRAVVFHRSLGAKFADVLPRE-GV
TH_4377|M.thermoresistible__bu KARTVPVNVNYHYTPREVADLLAYVKPRAVIYHRSLGAKFAGVLPPS-GA
MSMEG_2231|M.smegmatis_MC2_155 KARTVPVNVNYYYSPREVAELLDHLRPSAAVYHRSLGAKFADVLPPR-SA
MAV_1592|M.avium_104 KARTVPVNVNYHYTPREVGELFDYLRPRAVIYHRGLGPKFADVLGRG-DV
MMAR_4013|M.marinum_M KARVVPVNVNHHYSPREIAELLEYVRPRGIIYHRALGARFADLLPAA-GA
MUL_3870|M.ulcerans_Agy99 AARVAPFNVNFRYVKNEPQYLLADAGATALIYHATFAPRVAEVLPELPRL
MLBr_02661|M.leprae_Br4923 RAGLIVVPLDPALPVNEQCIRSQAAGVRVTLVDSLALEGVSDQRAATMRY
. :: * : . .:
Mb3544c|M.bovis_AF2122/97 RTILVVEDGS--------DQDYRRYGGVEFYSAIAAGSPERDFGERSADA
Rv3515c|M.tuberculosis_H37Rv RTILVVEDGS--------DQDYRRYGGVEFYSAIAAGSPERDFGERSADA
MAB_4163c|M.abscessus_ATCC_199 KTAIVVEDGA--------DGSFDSYGGVPFADALAQGSPERDFEERSPDD
Mflv_4349|M.gilvum_PYR-GCK EVMISIDDG---------SDAPELTGAVTLDDALAAGDAD-QPITPSPDD
Mvan_1995|M.vanbaalenii_PYR-1 DLMISIDDG---------SGAPELTGAVRLDDALAAGETD-QHITPSPDD
TH_4377|M.thermoresistible__bu ELLIAIDDGPEGSDGSDCSNGVGLSGAIDLEDALAQGDVD-QPITPSPDD
MSMEG_2231|M.smegmatis_MC2_155 RLLICVDDG----------PGPDLPGAIPLDDALAQSGSD-CVAPASPDD
MAV_1592|M.avium_104 DLLIAVDDG---------SEAPQLPGAVSLNDALAQGDTG-HPVPGSPDD
MMAR_4013|M.marinum_M DLLVSIDDG---------SGAAELPGAVSLDEVVTAGAPN-YRPTGSPDD
MUL_3870|M.ulcerans_Agy99 RVLIQIADD---------SGNGLLDGAVDYESIIANSSPEPLPVQPSPDD
MLBr_02661|M.leprae_Br4923 WPIAVSYGS--------VTGASEGSLLVHLDDTAALHPVTSTPDGLRHDD
.. : . : *
Mb3544c|M.bovis_AF2122/97 IYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGEFVKDEYDLAKAAA
Rv3515c|M.tuberculosis_H37Rv IYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGEFVKDEYDLAKAAA
MAB_4163c|M.abscessus_ATCC_199 IFLIYTGGTTGFPKGVMWRHEDIYRSLFGGINYVTGEYIEGEWDLAKQGA
Mflv_4349|M.gilvum_PYR-GCK VMMICTGGTTGRPKGVMWRQSDTYVVSMNGADHES------VDEIHAKVQ
Mvan_1995|M.vanbaalenii_PYR-1 VMMICTGGTTGRPKGVMWRQSDTYVVSMNGADHES------VAEIHDKVQ
TH_4377|M.thermoresistible__bu VLMICTGGTTGRPKGVMWRQSDTYTVSMNGADHDS------VDEIHDKVR
MSMEG_2231|M.smegmatis_MC2_155 LLMICTGGTTGRPKAVMWRQGDIYVSSMNGADHDD------ASEIHAKVA
MAV_1592|M.avium_104 LLMICTGGTTGRPKGVLWRQSDIYVSSMVGADHAC------AQEIRDKVS
MMAR_4013|M.marinum_M LIMMCTGGTTGRPKGVLWRQGDMYVASMVGADHAN------VDEIHQKVR
MUL_3870|M.ulcerans_Agy99 LYVLYTGGTTGMTKGVLWRQHDIFMTSFGGRDLYSGQPVNSVDEIVARTT
MLBr_02661|M.leprae_Br4923 AMIMFTGGTTGLPKMVPWTDGNIAGS---------------VHAIITAYQ
:: ****** .* * * . : :
Mb3544c|M.bovis_AF2122/97 ANPPMIRYPIPPMIHGATQSATWMALFSGQTTVLAP---EFNADEVWRTI
Rv3515c|M.tuberculosis_H37Rv ANPPMIRYPIPPMIHGATQSATWMALFSGQTTVLAP---EFNADEVWRTI
MAB_4163c|M.abscessus_ATCC_199 EAAPFIGFPIPPMIHGATQAATFMALFQGRTTVLAP---EFNPEEVWELI
Mflv_4349|M.gilvum_PYR-GCK -HAGPPWFAVSPLMHAAGMWTAFAALLNGQTVILYD-KPTLDAAAVLETA
Mvan_1995|M.vanbaalenii_PYR-1 -HAGPPWFAVSPLMHAAGMWTAFAALLNGQTVILYD-KPTLDSATVLSTA
TH_4377|M.thermoresistible__bu -HAGPPWFAVSPLMHAAGMWTAFAGALSGQTVVLYD-STRFDARRVLRTA
MSMEG_2231|M.smegmatis_MC2_155 -NAGPPWFAVSPLMHAAGLWTAFSGLLSGQTVVLHDTKPRFDPRAVLETA
MAV_1592|M.avium_104 GAAGAPWFAVSPLMHAAGMWTAFAAIMSGTTVVLYDTGKKLDPRSVWETA
MMAR_4013|M.marinum_M -LGGSPWFAVSPLMHAAGLWTAFSGFLSGFPVVLYDDRAKLDVRSVWATA
MUL_3870|M.ulcerans_Agy99 AGPGTKLLVLPPLIHGAAQWTVMTALTTGQTVVFASVVDHLDPRDVVRTI
MLBr_02661|M.leprae_Br4923 LGPQDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDI
: *: *. :. . . .:: :. .
Mb3544c|M.bovis_AF2122/97 HKHKVNLLFFTGDAMARPLVDAL--VKGNDYDLSSLFLLASTAALFSPSI
Rv3515c|M.tuberculosis_H37Rv HKHKVNLLFFTGDAMARPLVDAL--VKGNDYDLSSLFLLASTAALFSPSI
MAB_4163c|M.abscessus_ATCC_199 EKHKINMLFFAGDAIGRPLIDALDTETGRARDLSSLWVLASSAALFSQTV
Mflv_4349|M.gilvum_PYR-GCK EREKVGLMTMVGDAYARPLIAELQ---RRPYDLSSLFAIGTGGAATNQRH
Mvan_1995|M.vanbaalenii_PYR-1 EREKVGLMTMVGDAYAGPLIDELR---RRPYDLSSLFAIGTGGAATNQRH
TH_4377|M.thermoresistible__bu EREKVGLMTMVGDAYAGPLVAEMR---QHRYDLSALFAVAAGGAATNPKH
MSMEG_2231|M.smegmatis_MC2_155 EREKVGLMTMVGDAYAAPIVEELR---RRTYDLSSLFAIGTGGAATNLKH
MAV_1592|M.avium_104 QRERVGMMTMVGDAYAAPLVAELR---RGSYDLSSLYAIGTGGAATNAKY
MMAR_4013|M.marinum_M EREKVGMVTMVGDAYAGPLVAELS---AHPYDLSALQAIGTGGAATNPKY
MUL_3870|M.ulcerans_Agy99 ERERVSVVTVVGNAIARPLVASIE---KGTADVSSLVAVANGGALLTPYV
MLBr_02661|M.leprae_Br4923 D--AVAATWYTAAPAIHRILLELASTQSFRSKRAKLRFIRSCSAPLTQET
. : .. . :: : . : * : .* .
Mb3544c|M.bovis_AF2122/97 KEKLLELLPNRVITDS------IGSSETGFGGTSVVAAGQAHGGGPRVRI
Rv3515c|M.tuberculosis_H37Rv KEKLLELLPNRVITDS------IGSSETGFGGTSVVAAGQAHGGGPRVRI
MAB_4163c|M.abscessus_ATCC_199 KERYLELLPNRVITDA------IGASETGTGGLSTVTKGQMHPGGPTVKI
Mflv_4349|M.gilvum_PYR-GCK QDALLELLPQITLING------YGSSETGNMAFGRSLRDDRKD--TFERR
Mvan_1995|M.vanbaalenii_PYR-1 QEALLELLPQITLING------YGSSETGNMAFGRSQADDRKD--TFERR
TH_4377|M.thermoresistible__bu QRALLDMLPQITFING------YGSSETGNVGFGRSQRGDEKE--TFELR
MSMEG_2231|M.smegmatis_MC2_155 QQALLDHIPQITLING------FGSSETGNMGFGHSQRGNQAE--TFQLR
MAV_1592|M.avium_104 QQALLELLPHITLING------YGSSETGNMGFGHSRTGTRTD--TFTLR
MMAR_4013|M.marinum_M KRALMERLPHVTIIEG------YGSSETGNMAFGHSRNRMASE--TFAMR
MUL_3870|M.ulcerans_Agy99 KQRLIAALPNAVIIDG------VGSSETGAQMHHLSASGAISTG-TFNAG
MLBr_02661|M.leprae_Br4923 AQALREEFLAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQST
: .: : *.
Mb3544c|M.bovis_AF2122/97 DHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTAETFRTING
Rv3515c|M.tuberculosis_H37Rv DHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTAETFRTING
MAB_4163c|M.abscessus_ATCC_199 SSTTTVLDEEGNPVQPGSGVRGLIAKSGHIPVGYFKDEKKTAETFKTFNG
Mflv_4349|M.gilvum_PYR-GCK DGVVLLSEDRTRFLEPGEDEIGWVAREGRIPLGYFDDADATARTFPVVDG
Mvan_1995|M.vanbaalenii_PYR-1 GGVVLLSEDHSRILQPGDQEVGWVAREGRIPLGYFDDAEATRRTFPQVEG
TH_4377|M.thermoresistible__bu DGALVVAEDYGRFLEPGETQIGWVARAGRIPLGYFDDPEGTSRTFPEVQG
MSMEG_2231|M.smegmatis_MC2_155 AGGLVLAEDHSRFLTPGEQGVGWVARNGRIPLGYFDDEAATANTFPEVEG
MAV_1592|M.avium_104 EGGLVLAEDYSRFLSPGEPQLGWVAREGRIPLGYFDDPDATRKTFPVIDG
MMAR_4013|M.marinum_M VGGAVASADRSSFLQPGTAEIGWAARMGRIPLGYFNDPEATRRTFPEIEG
MUL_3870|M.ulcerans_Agy99 PDINVAAEDLSAILPAGHEGIGWLAQRGYVPLGYKGDAAKTATTFPVING
MLBr_02661|M.leprae_Br4923 GVQIRIVGSDGQPLPPDTVGEVWLRG-STVVRGYLGDPAITAANFTHG--
. : .. . : ** * * .*
Mb3544c|M.bovis_AF2122/97 VRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDV
Rv3515c|M.tuberculosis_H37Rv VRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDV
MAB_4163c|M.abscessus_ATCC_199 VRYAIPGDWATVEADGTVTMLGRGSVSINTGGEKVFPEEVESVLKGHPAV
Mflv_4349|M.gilvum_PYR-GCK RRVVISGDRASLEADGTIRLYGRDSLVINTGGEKVFVEEVEEVLRAHHGV
Mvan_1995|M.vanbaalenii_PYR-1 RRVVISGDRASLEPDGTLRLYGRDSLVVNTGGEKVFVEEVEEVLRAHGGV
TH_4377|M.thermoresistible__bu RRVVISGDRGSLAPDGTLVLYGRDSLVVNTGGEKVFVEEVEEVLRAHPGI
MSMEG_2231|M.smegmatis_MC2_155 QRVVVSGDRAALEADGTLRLYGRDSLVVNTGGEKVFVEEVEEVLRAHAAV
MAV_1592|M.avium_104 KQVVISGDRAALEPDGTLRLFGRDSLVVNTGGEKVFVEEVEEVLRAHPAV
MMAR_4013|M.marinum_M HRVVIPGDRATIENDGTIRLLGRDSLVVNTGGEKVFVEEVEEVLRGHPDI
MUL_3870|M.ulcerans_Agy99 VRYAVPGDRARHRADGCIELLGRDSATINSGGEKIFAEEVETAIASHPAV
MLBr_02661|M.leprae_Br4923 --WLRTGDLGSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNV
.** . * : : ** . :* .***: *.** .: .* :
Mb3544c|M.bovis_AF2122/97 FDALVVGVPDPRYGQQVAAVVQARPG----CRPSLAELDSFVRSEIAGYK
Rv3515c|M.tuberculosis_H37Rv FDALVVGVPDPRYGQQVAAVVQARPG----CRPSLAELDSFVRSEIAGYK
MAB_4163c|M.abscessus_ATCC_199 FDAVVVGVPDEKWGQHVGAVIAVREG----VELTFEDLDAHARKEIAGYK
Mflv_4349|M.gilvum_PYR-GCK ADALVIGRDSDRWGQEIVALVQKQP--DAVVDP--SALLDACHEALARYK
Mvan_1995|M.vanbaalenii_PYR-1 ADALVVGRDSDRWGQEIVALIEKAP--GADVES--EALLLVCNSALARFK
TH_4377|M.thermoresistible__bu VDALVVGRPSERWGQEVVALVALRG--DSERDSSPSALHAHCTAALAGFK
MSMEG_2231|M.smegmatis_MC2_155 ADALVVGRPSERWGEEIVAIVALRDNHGSDHDVTGEALREHCSTRLARFK
MAV_1592|M.avium_104 ADALVVGRPSGRWGEEIVALVELRAGTGAAADE----LHAHCTSRLARFK
MMAR_4013|M.marinum_M ADALVVGRASQRWGQEVVALVAARP--GVDLAGSERALYALCTAKLAHFK
MUL_3870|M.ulcerans_Agy99 ADVVVAGRPSERWGQEVVAVVALDP--DAAADA--EELVAHAAKSLARYK
MLBr_02661|M.leprae_Br4923 MEVAVFGDPDKVYGETVTAVIVPREV----IAPTPSELAVFCRDRLAAFE
:. * * . :*: : *:: * :* ::
Mb3544c|M.bovis_AF2122/97 VPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGG
Rv3515c|M.tuberculosis_H37Rv VPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGG
MAB_4163c|M.abscessus_ATCC_199 VPRSIWIVDSVKRNPAGKADYRWAKEVSETEKVDLVNSKHVNTGA
Mflv_4349|M.gilvum_PYR-GCK APKEFLFVDRVRRLGNGKADYRWAKSQVAPQDTLAGQP-------
Mvan_1995|M.vanbaalenii_PYR-1 APKEFIFVDKVRRLGNGKADYRWAKSQATQRDTVVGQS-------
TH_4377|M.thermoresistible__bu TPKEFITVDEIRRLGNGKADYRWAREVAVQSAMRMA---------
MSMEG_2231|M.smegmatis_MC2_155 TPKDVMFVEQVRRLGNGKADYRWAKAHAAQRVEMA----------
MAV_1592|M.avium_104 APKEFLFVAAVQRLGNGKADYRWAKRHAVTEASEKAPMST-----
MMAR_4013|M.marinum_M APKAFIFVSHIQRLGNGKPNYRWAKQAAAQQLPVGGSA-------
MUL_3870|M.ulcerans_Agy99 LPKAIVFRAGIQRSPSGKADYRWAKEQAADG--------------
MLBr_02661|M.leprae_Br4923 VPTRFQEASALPHTAKGSLDRRAVAEQFAHRG-------------
* . : : *. : * .