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VAVALNIADLAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKDDKVGLYCRNRIEIVI AMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDY RRYGGVEFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGEFVKDE YDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFSGQTTVLAPEFNADEVWRTIHKHKVNLLFFTGDAM ARPLVDALVKGNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSVVAAGQAHG GGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTAETFRTINGVRYAIPGDYAQVE EDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3544c | fadD19 | - | 100% (548) | acyl-CoA synthetase |
M. bovis AF2122 / 97 | Mb3542c | fadD18 | 6e-95 | 99.40% (167) | fatty-acid-CoA ligase |
M. bovis AF2122 / 97 | Mb0276 | fadD2 | 1e-41 | 28.54% (515) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_1543 | - | 0.0 | 84.43% (546) | acyl-CoA synthetase |
M. tuberculosis H37Rv | Rv3515c | fadD19 | 0.0 | 100.00% (548) | acyl-CoA synthetase |
M. leprae Br4923 | MLBr_02546 | fadD2 | 7e-37 | 26.93% (505) | acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_4163c | - | 0.0 | 68.19% (547) | acyl-CoA synthetase |
M. marinum M | MMAR_5001 | fadD19_1 | 0.0 | 90.18% (550) | fatty-acid-CoA ligase FadD19_1 |
M. avium 104 | MAV_0644 | - | 0.0 | 90.11% (546) | acyl-CoA synthetase |
M. smegmatis MC2 155 | MSMEG_5914 | - | 0.0 | 83.76% (548) | acyl-CoA synthetase |
M. thermoresistible (build 8) | TH_1821 | fadD19 | 0.0 | 81.17% (547) | PROBABLE FATTY-ACID-CoA LIGASE FADD19 (FATTY-ACID-CoA |
M. ulcerans Agy99 | MUL_4075 | fadD19_1 | 0.0 | 90.18% (550) | acyl-CoA synthetase |
M. vanbaalenii PYR-1 | Mvan_5215 | - | 0.0 | 84.62% (546) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment Mb3544c|M.bovis_AF2122/97 -------------------------------------MAVALN----IAD Rv3515c|M.tuberculosis_H37Rv -------------------------------------MAVALN----IAD MMAR_5001|M.marinum_M -------------------------------------MAVALN----IAD MUL_4075|M.ulcerans_Agy99 -------------------------------------MAVALN----IAD MAV_0644|M.avium_104 -------------------------------------MAVALN----IAD MSMEG_5914|M.smegmatis_MC2_155 ---------------------------------------MALN----IAD Mvan_5215|M.vanbaalenii_PYR-1 ---------------------------------------MALN----IAD Mflv_1543|M.gilvum_PYR-GCK ---------------------------------------MALN----IAD TH_1821|M.thermoresistible__bu ---------------------------------------VALN----IAD MAB_4163c|M.abscessus_ATCC_199 ---------------------------------------MALN----IAD MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM :*:. :* Mb3544c|M.bovis_AF2122/97 LAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKDDKVG Rv3515c|M.tuberculosis_H37Rv LAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKDDKVG MMAR_5001|M.marinum_M LAEHAIDAVPDRVALICGDEQLTYAQLEEKANRLAHHLIDQGVGKGDKVG MUL_4075|M.ulcerans_Agy99 LAEHAIDAVPDRVALICGDEQLTYAQLEEKANRLAHHLIDQGVRKGDKVG MAV_0644|M.avium_104 LAEHAIDAVPDRVALICGDEKLTYAELEEKANRLAHYLLDQGVKKDDKVG MSMEG_5914|M.smegmatis_MC2_155 LAEHAIDAVPDRVALISGGDQLTYGQLEEKANRFAHYLIDQGVKKDDKVG Mvan_5215|M.vanbaalenii_PYR-1 LAEHAIDAVPDRVALISGDEQLTYAELEEKSNRLAHYLIDQGVKKDDKVG Mflv_1543|M.gilvum_PYR-GCK LAEHAIDAVPDRVAIITGDEQLTYAQLEEKANRLAHYLLDQGVKKDDKVG TH_1821|M.thermoresistible__bu LTEHAIDAVPDRVALICGDDQLTYAQLEEKANRLAHYLLDQGVRKDDKVG MAB_4163c|M.abscessus_ATCC_199 LIEHAIDTMPDRVAIISGDRKLTYAELEEQSNRLGHYLQSQGVGPGDKVG MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA * . *.*.*:* *** :*: :: :.: * :** .* :. Mb3544c|M.bovis_AF2122/97 LYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMVALVHE Rv3515c|M.tuberculosis_H37Rv LYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMVALVHE MMAR_5001|M.marinum_M LYCRNRIEIVIAMLGIIKAGAILINVNFRYVEGELKYLFDNSDMVALVHE MUL_4075|M.ulcerans_Agy99 LYCRNRIEIVIAMLGIIKAGAILINVNFRYVEGELKYLFDNSDMVALVHE MAV_0644|M.avium_104 LYCRNRNEIVIAMLGIVKAGAILVNVNYRYVEGELRYLFDNSDMVALVHE MSMEG_5914|M.smegmatis_MC2_155 LYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELKYLFENSDMVALVHE Mvan_5215|M.vanbaalenii_PYR-1 LYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELKYLFENSDMVALVHE Mflv_1543|M.gilvum_PYR-GCK LYCRNRNEIVIAMLGIVKAGAILVNVNFRYVEGELKYLFDNSDMVALVHE TH_1821|M.thermoresistible__bu LYCRNRNEIVVAALACVKAGAIAVNVNFRYVEAELRYLFDNSDMVALVHE MAB_4163c|M.abscessus_ATCC_199 LYCRNGIEIVIALTAIVKIRAISVNVNYRYVEAELHYLFENSDMAALVHE MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD : .** :*:* . : * : :* .: ::: : :... .:::: Mb3544c|M.bovis_AF2122/97 RRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGVEFYSAIAAGSPER Rv3515c|M.tuberculosis_H37Rv RRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGVEFYSAIAAGSPER MMAR_5001|M.marinum_M RQYADRVANVLPDTPNVKTILVVQDGSDKDYRRYGGVEFYSAIADSSPER MUL_4075|M.ulcerans_Agy99 RQYADRVANVLPDTPNVKTILVVQDGSDKDYQRYGGVEFYSAIADGSPER MAV_0644|M.avium_104 RQYSDRVANVLPDTPNVKTILVVEDGSDKDYQRYGGVEFYSALEKGSPER MSMEG_5914|M.smegmatis_MC2_155 RRYSDRVANVLPETPDIKTILVVEDGSDDDYERFGGVEFYSALEKSSPER Mvan_5215|M.vanbaalenii_PYR-1 RRYADRVANVLPETPNVKTILVVEDGTDEDYQRYGGVEFYSALAQGSPER Mflv_1543|M.gilvum_PYR-GCK RRYADRVANVLPETPKVKTILVIEDGSDDDYERYGGVEFNAALEQGSPER TH_1821|M.thermoresistible__bu RQYSDRVANVLPETPKVKTIVVIEDGSDLDYQRYGGVEFEAALAQGSPER MAB_4163c|M.abscessus_ATCC_199 RRYSDKVANVLPSTPNVKTAIVVEDGADGSFDSYGGVPFADALAQGSPER MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSSAPAP .*:. *::. * .::: * * : : * .:* Mb3544c|M.bovis_AF2122/97 DFGE----RSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE Rv3515c|M.tuberculosis_H37Rv DFGE----RSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE MMAR_5001|M.marinum_M DFAELQRERSADDIYILYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE MUL_4075|M.ulcerans_Agy99 DFAELQRERSADDIYILYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE MAV_0644|M.avium_104 DFGP----RSADDIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE MSMEG_5914|M.smegmatis_MC2_155 DFGP----RSEDDIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE Mvan_5215|M.vanbaalenii_PYR-1 DFGP----RSEDDIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE Mflv_1543|M.gilvum_PYR-GCK DFGP----RSEDDIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGE TH_1821|M.thermoresistible__bu DFGP----RSADDIYLLYTGGTTGFPKGVMWRHEDIYRVLLGGIDFATGE MAB_4163c|M.abscessus_ATCC_199 DFEE----RSPDDIFLIYTGGTTGFPKGVMWRHEDIYRSLFGGINYVTGE MLBr_02546|M.leprae_Br4923 KVRK-------RASIIILTSGTTGTPKGANRNTPASLAPLGG-------- .. :: *.**** ***. . * * Mb3544c|M.bovis_AF2122/97 FVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFSGQTTVLAPE Rv3515c|M.tuberculosis_H37Rv FVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFSGQTTVLAPE MMAR_5001|M.marinum_M FIKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMSIFSGQTTVLAPE MUL_4075|M.ulcerans_Agy99 FIKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMSIFSGQTTVLAPE MAV_0644|M.avium_104 FVKDEYDLAKAAAENPPMIRYPIPPMIHGATQSATWMSIFSGQTTVLAPE MSMEG_5914|M.smegmatis_MC2_155 PIEDEYGLAKQAAANPPMVRYPIPPMIHGATQSATWMALFAGGTVLLTPE Mvan_5215|M.vanbaalenii_PYR-1 PIADEYGLAKQAVESGPMVRYPIPPMIHGATQSATWMALFSGQTTVLTPE Mflv_1543|M.gilvum_PYR-GCK PIADEYDLSRSAVDNPPMIRLPIPPMIHGATQSATWMALFSGHTVVLTPE TH_1821|M.thermoresistible__bu YVADEYDHARQAKENPPMVRYPIPPMIHGATQSATWMALFGGGTVVLAPE MAB_4163c|M.abscessus_ATCC_199 YIEGEWDLAKQGAEAAPFIGFPIPPMIHGATQAATFMALFQGRTTVLAPE MLBr_02546|M.leprae_Br4923 -------ILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLVLRRR : .**:*. : :::* * * :* . Mb3544c|M.bovis_AF2122/97 FNADEVWRTIHKHKVNLLFFTGDAMARPLVDALVKGND----YDLSSLFL Rv3515c|M.tuberculosis_H37Rv FNADEVWRTIHKHKVNLLFFTGDAMARPLVDALVKGND----YDLSSLFL MMAR_5001|M.marinum_M FDADQVWRTISDRKVNLLFFTGDAMARPLLDALMKDND----YDLSSLFL MUL_4075|M.ulcerans_Agy99 FDADQVWRTISDRKVNLLFFTGDAMARPLLDALMKDND----YDLSSLFL MAV_0644|M.avium_104 FNADEVWRTIHEHKVNLVFFTGDAMARPLLDALNKDHD----YDLSSLFL MSMEG_5914|M.smegmatis_MC2_155 FNPDEVWQAIHDHKVNLLFFTGDAMARPLLDSLLAAKDAGKEYDLSSLFL Mvan_5215|M.vanbaalenii_PYR-1 FDAEAVWRTIHEHKVNLLFFTGDAMARPLLDALLAAQDAGDQYDLSSLFL Mflv_1543|M.gilvum_PYR-GCK FDADQIWRMIHEHKVNLLFFTGDAMARPLLDALLAHQEEGNTYDLSSLFL TH_1821|M.thermoresistible__bu FDPAEVWRTCEKHKVNLLFFTGDAMARPLVDALTAPGAN---YDLSNLFL MAB_4163c|M.abscessus_ATCC_199 FNPEEVWELIEKHKINMLFFAGDAIGRPLIDALDTETGR--ARDLSSLWV MLBr_02546|M.leprae_Br4923 FKPATVLEDIEKHQATAMVVVPVMLSR-ILDTLENLETK---SDLSSLRV *.. : . .:: . :... :.* ::*:* ***.* : Mb3544c|M.bovis_AF2122/97 LASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSVVAAGQAHGG Rv3515c|M.tuberculosis_H37Rv LASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSVVAAGQAHGG MMAR_5001|M.marinum_M LASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSIVGAGQATTG MUL_4075|M.ulcerans_Agy99 LASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSIVGAGQATTG MAV_0644|M.avium_104 LASTAALFSPSIKERLLELLPNRVITDSIGSSETGFGGTSIVAKDAPHAG MSMEG_5914|M.smegmatis_MC2_155 LASTAALFSTSLKEKFLELLPNRVITDSIGSSETGFGGTSIVAKGQSHTG Mvan_5215|M.vanbaalenii_PYR-1 LASTAALFSTSLKEKFLELLPNRIITDSIGSSETGFGGTSIVAKGESHTG Mflv_1543|M.gilvum_PYR-GCK LASTAALFSTSIKEKFLELLPNRIITDSIGSSETGFGGTSIVAKGESHTG TH_1821|M.thermoresistible__bu LASTAALFSPSLKDQLLELLPNRIITDSIGSSETGFGGSSVVTKGQTHTG MAB_4163c|M.abscessus_ATCC_199 LASSAALFSQTVKERYLELLPNRVITDAIGASETGTGGLSTVTKGQMHPG MLBr_02546|M.leprae_Br4923 VFVSGSQLGAELATRALEELG-PVIYNMYGSTEIAFATIAGPKDLQINSA : :.: :. : : ** * :* : *::* . . : . Mb3544c|M.bovis_AF2122/97 GP-RVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTAE Rv3515c|M.tuberculosis_H37Rv GP-RVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTAE MMAR_5001|M.marinum_M GP-RVTIDHRTVVLDEEGNEVKPGSGVRGIIAKKGNIPVGYYKDEKKTAE MUL_4075|M.ulcerans_Agy99 GP-RVTIDHRTVVLDEEGNEVKPGSGVRGIIAKKGNIPVGYYKDEKKTAE MAV_0644|M.avium_104 GP-RVTIDHRTVVLDEEGNEVKPGSGVRGLIAKKGNIPVGYYKDEKKTAE MSMEG_5914|M.smegmatis_MC2_155 GP-RVTIDKNTVVLDDDGNEVKPGSGVRGVIAKRGHIPLGYYKDEKKTAE Mvan_5215|M.vanbaalenii_PYR-1 GP-RVTIDKNTVVLDEDGNPVTPGSGVRGIIAKRGHIPVGYFKDEKKTAE Mflv_1543|M.gilvum_PYR-GCK GP-RVTIDKNTKVLDEDGNEVEPGSGKRGVIAKCGHIPVGYFKDEKKTAE TH_1821|M.thermoresistible__bu GP-RVTIDKNVVVLDEDGNEVKPGSGVRGLIAKRGHIPLGYYKDEKKTAE MAB_4163c|M.abscessus_ATCC_199 GP-TVKISSTTTVLDEEGNPVQPGSGVRGLIAKSGHIPVGYFKDEKKTAE MLBr_02546|M.leprae_Br4923 TVGPVVKGVKVKILDDSGKEVPRGQ-VGRIFVGNAFPFEGYTGGGGK--- * . . :**:.*: * *. ::. . ** . * Mb3544c|M.bovis_AF2122/97 TFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAA Rv3515c|M.tuberculosis_H37Rv TFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAA MMAR_5001|M.marinum_M TFKTINGVRYAIPGDYAMVEADGTVTMLGRGSVSINSGGEKIYPEEVEAA MUL_4075|M.ulcerans_Agy99 TFKTINGVRYAIPGDYAMVEADGTVTMLGRGSVSINSGGEKIYPEEVEAA MAV_0644|M.avium_104 TFKTFNGVRYAIPGDYALVEEDGTVTMLGRGSVSINSGGEKIYPEEVEGA MSMEG_5914|M.smegmatis_MC2_155 TFKTINGVRYAIPGDYAEVEADGSVTMLGRGSVSINSGGEKIYPEEVEAA Mvan_5215|M.vanbaalenii_PYR-1 TFKTINGVRYAIPGDYATVEADGSVTMLGRGSVSINSGGEKIYPEEVEAA Mflv_1543|M.gilvum_PYR-GCK TFRTYNGVRYAIPGDYAEVEADGTVTMLGRGSVSINSGGEKIYPEEVEAA TH_1821|M.thermoresistible__bu TFKTINGVRYAIPGDWATVEADGTVTMLGRGSQSINSGGEKIYPEEVEGA MAB_4163c|M.abscessus_ATCC_199 TFKTFNGVRYAIPGDWATVEADGTVTMLGRGSVSINTGGEKVFPEEVESV MLBr_02546|M.leprae_Br4923 --QIIDGLLS--SGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDL : :*: .** . .: .. : : **.. * :***:::* *** Mb3544c|M.bovis_AF2122/97 LKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIA Rv3515c|M.tuberculosis_H37Rv LKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIA MMAR_5001|M.marinum_M LKGHPDVFDALVVGVPDPRYGQHVAAVVAPRPGSRPSLAELDGFVRSAIA MUL_4075|M.ulcerans_Agy99 LKGHPDVFDALVVGVPDPRYGQHVAAVVAPRPGSRPSLAELDGFVRSAIA MAV_0644|M.avium_104 LKGHPDVFDALVVGVPDPRYGQHVAAVVQPRPGTRPSLAELDRFVRSEIA MSMEG_5914|M.smegmatis_MC2_155 LKGHPDVFDALVVGVPDPRFGQHVAAVVHPREGTRPTLAELDAHVRTEIA Mvan_5215|M.vanbaalenii_PYR-1 LKGHPDVFDALVVGVPDPRFGQHVAAVVQPREGTRPALADLDAFVRTQIA Mflv_1543|M.gilvum_PYR-GCK LKGHPDVFDALVVGVPDPRFGQHVAAVVHPRDGARPSLADLDAFVRKEIA TH_1821|M.thermoresistible__bu LKGHPDVFDALVVGVPDERFGQCVAAVVQRRPGTNPTLADLDAFVRQEIA MAB_4163c|M.abscessus_ATCC_199 LKGHPAVFDAVVVGVPDEKWGQHVGAVIAVREGVELTFEDLDAHARKEIA MLBr_02546|M.leprae_Br4923 ISGHPEVVEATAIGVDDKEWGARLRAFVVKKQDATIDEDAIKAYVRDHLA :.*** *.:* .:** * .:* : *.: : . :. ..* :* Mb3544c|M.bovis_AF2122/97 GYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGG-- Rv3515c|M.tuberculosis_H37Rv GYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGG-- MMAR_5001|M.marinum_M GYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAAHVSA---- MUL_4075|M.ulcerans_Agy99 GYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAAHVSA---- MAV_0644|M.avium_104 GYKVPRSLWLVDEVKRSPAGKPDYRWAKEQTEARPADDVHAAHVSA---- MSMEG_5914|M.smegmatis_MC2_155 GYKVPRSLWLVDEIKRSPAGKPDYRWAKDVTEERPADEVHANHVAANAK- Mvan_5215|M.vanbaalenii_PYR-1 GYKVPRSLWLVDEVKRSPAGKPDYRWAKDVTEERPADDVHANHVGAK--- Mflv_1543|M.gilvum_PYR-GCK GYKVPRSLWLVDEIKRSPAGKPDYRWAKDTTEERPADEVHAKHVGAN--- TH_1821|M.thermoresistible__bu GYKVPRKIWWVDEIQRTPAGKPDYRWAKEQTEAREPDEVHSSHAGAGGGA MAB_4163c|M.abscessus_ATCC_199 GYKVPRSIWIVDSVKRNPAGKADYRWAKEVSETEKVDLVNSKHVNTGA-- MLBr_02546|M.leprae_Br4923 RYKVPREVIFLEELPRNPTGKVLKRELRDFEVH----------------- *****.: ::.: *.*:** * :: Mb3544c|M.bovis_AF2122/97 - Rv3515c|M.tuberculosis_H37Rv - MMAR_5001|M.marinum_M - MUL_4075|M.ulcerans_Agy99 - MAV_0644|M.avium_104 - MSMEG_5914|M.smegmatis_MC2_155 - Mvan_5215|M.vanbaalenii_PYR-1 - Mflv_1543|M.gilvum_PYR-GCK - TH_1821|M.thermoresistible__bu K MAB_4163c|M.abscessus_ATCC_199 - MLBr_02546|M.leprae_Br4923 -