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VEYNIAQVFSAVAAANPDRDCIVYGDRRFTFAQTERRARRLARALHQWGFGASRERSQLAPYESGQSHLG LYMTNCNEFLEGMIGAYQARVAPFNINYRYVADELAYLLRNAGADAVIYHARFGPTLAETLEKAGGEPQL IHVDDESGNDPLPGAVRYEELLASVSDEPLDVELSPDDLYMLYTGGTTGMPKAVLWRQHDIFMNSMGGRT FGTGELVTGLDDIVERSRQGGPGSMTVAPLMHGAAQWAAFISLCGGRPFVMPQMATRFDPAAAWAMAARE RVMSLSIVGDAFGRPLLDELESGDYDLSALSVLISGGAALSAGVKQRFVDLLPQLTILDAGGSSESGSQM VQVSSRVLPASGRFDPIPGAVVVSEDLARILTPGDSEIGWLAQQGVIPLGYLGDKAKTARTFPVIEGIRH SVPGDRARWDADGTIELLGRDSVTINSGGEKIFVEEVEAAIAEHPAVYDVVVTGRPSPRWGNEVVAIVQL AEGAAPDPDSIIGEAARHIARYKLPKEIVFCPKVQRSPAGKPDYRWAKATVAPQD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2064 | - | - | 100% (545) | fatty-acid-CoA ligase |
| M. marinum M | MMAR_4007 | fadD19_2 | e-160 | 54.14% (543) | fatty-acid-CoA ligase FadD19_2 |
| M. marinum M | MMAR_4013 | - | e-113 | 42.75% (545) | fatty-acid-CoA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3544c | fadD19 | 1e-95 | 38.38% (542) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4335 | - | 1e-163 | 54.55% (539) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3515c | fadD19 | 1e-95 | 38.38% (542) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-27 | 24.02% (533) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4163c | - | 1e-98 | 37.34% (541) | acyl-CoA synthetase |
| M. avium 104 | MAV_1600 | - | 1e-165 | 55.20% (538) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_3687 | - | 1e-162 | 54.16% (541) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4443 | - | 1e-162 | 54.09% (538) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3279 | - | 0.0 | 98.70% (386) | fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_2010 | - | 1e-163 | 54.55% (539) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3544c|M.bovis_AF2122/97 ------------------------MAVALNIADLAEHAIDAV--------
Rv3515c|M.tuberculosis_H37Rv ------------------------MAVALNIADLAEHAIDAV--------
MAB_4163c|M.abscessus_ATCC_199 --------------------------MALNIADLIEHAIDTM--------
MMAR_2064|M.marinum_M --------------------------MEYNIAQVFSAVAAAN--------
MUL_3279|M.ulcerans_Agy99 --------------------------MEYNIAQVFSAVAAAN--------
Mflv_4335|M.gilvum_PYR-GCK ---------------------MTEPN-QFTVPAAADAVAAVI--------
Mvan_2010|M.vanbaalenii_PYR-1 ---------------------MTESI-QFTVPAAADAVAAAI--------
MAV_1600|M.avium_104 ---------------------MSDTTTAFTVPAVAKAVAAAI--------
TH_4443|M.thermoresistible__bu ------------------------MTTEFTVPQVADTVAAVL--------
MSMEG_3687|M.smegmatis_MC2_155 ------------------------MSVSFDLSTVFSTVAAAV--------
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
. .
Mb3544c|M.bovis_AF2122/97 ---------PDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQK-----
Rv3515c|M.tuberculosis_H37Rv ---------PDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQK-----
MAB_4163c|M.abscessus_ATCC_199 ---------PDRVAIISGDRKLTYAELEEQSNRLGHYLQSQGVGP-----
MMAR_2064|M.marinum_M ---------PDRDCIVYGDRRFTFAQTERRARRLARALHQWGFGASRERS
MUL_3279|M.ulcerans_Agy99 ---------PDRDCIVYGDRRFTFAQTERRARRLARALHQWGFGASRERS
Mflv_4335|M.gilvum_PYR-GCK ---------GDREFIIQGERRYTYAQIVERSNRLAAFLHAQGLGCHTERS
Mvan_2010|M.vanbaalenii_PYR-1 ---------GDREFIVQGDRRYTYTQIVERSNRLAAYLHAQGLGCHTERT
MAV_1600|M.avium_104 ---------PDRELIIQGDRRYSYRQVIERSNRLAAYLHSQGLGCHTERE
TH_4443|M.thermoresistible__bu ---------PDRELVVHRDRRFTYTDIIARSNRLAAYLHSRGLGCHTERD
MSMEG_3687|M.smegmatis_MC2_155 ---------PDQTFVVWRDRRLTYAQFDAHVDGFAHFLVSAGLGVHTERA
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRG-----
.: :: : :: : :. * *.
Mb3544c|M.bovis_AF2122/97 --------DDKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRY
Rv3515c|M.tuberculosis_H37Rv --------DDKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRY
MAB_4163c|M.abscessus_ATCC_199 --------GDKVGLYCRNGIEIVIALTAIVKIRAISVNVNYRYVEAELHY
MMAR_2064|M.marinum_M QLAPYESGQSHLGLYMTNCNEFLEGMIGAYQARVAPFNINYRYVADELAY
MUL_3279|M.ulcerans_Agy99 QLAPYESGQSHLGLYMTNCNEFLEGMVGAYQARVAPFNINYRYVADELAY
Mflv_4335|M.gilvum_PYR-GCK ELPGHEVGQDLLGIYAYNGPEYVEGMLGAWRARVAPFNVNYRYVKSELQY
Mvan_2010|M.vanbaalenii_PYR-1 ALPGHEVGQDLLGIYSHNGPEYVEGMLGAWRARVAPFNVNYRYVKSELHY
MAV_1600|M.avium_104 ALAGHEVGQDLLGLYAYNGNEFVEALLGAFAARVAPFNVNFRYVKSELHY
TH_4443|M.thermoresistible__bu GLAPHECGQDLLGIYAYNGSEYLEGLLGAFRARVAPFNVNFRYVRAELEY
MSMEG_3687|M.smegmatis_MC2_155 ALAGHESGQDHLGIYLRNGNEYLEAMIGSYRARVAPFNVSYRYVEEELLY
MLBr_02546|M.leprae_Br4923 --------GDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKE
. :.: * : . . . . :. .: ::
Mb3544c|M.bovis_AF2122/97 LFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGV
Rv3515c|M.tuberculosis_H37Rv LFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGV
MAB_4163c|M.abscessus_ATCC_199 LFENSDMAALVHERRYSDKVANVLPSTPNVKTAIVVEDGADGSFDSYGGV
MMAR_2064|M.marinum_M LLRNAGADAVIYHARFGPTLAETLEKAGGEPQLIHVDDESGNDP-LPGAV
MUL_3279|M.ulcerans_Agy99 LLRNAGADAVIYHARFGPTLAETLEKAGGEPQLIHVDDESGNDP-LPGAV
Mflv_4335|M.gilvum_PYR-GCK LLADAGATALLYHSAFAPRLAEVLADLPSLKVLIQIADDSGNEL-LPGAV
Mvan_2010|M.vanbaalenii_PYR-1 LLADSGATALLYHAAFAPRLAEVLADLPNLKVLIQIADDSGNEL-LPGAV
MAV_1600|M.avium_104 LLADSEATALIYHAAFAPRVAEILPDLPRLRVLIQIADESGNEL-LDGAV
TH_4443|M.thermoresistible__bu LLTDAGATALLYHAAFAPRVAEILPNLPRRPVLIQIADDSGHEL-LEGAV
MSMEG_3687|M.smegmatis_MC2_155 LLTDSNARALVYNAEFAPRVAAIRDRLPNLAVLIQVADDSGNEL-LPGAV
MLBr_02546|M.leprae_Br4923 VSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPG--STDE
: .:::. : :: *
Mb3544c|M.bovis_AF2122/97 EFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLF
Rv3515c|M.tuberculosis_H37Rv EFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLF
MAB_4163c|M.abscessus_ATCC_199 PFADALAQGSPERDFEERSPDDIFLIYTGGTTGFPKGVMWRHEDIYRSLF
MMAR_2064|M.marinum_M RYEELLASVSDEPLDVELSPDDLYMLYTGGTTGMPKAVLWRQHDIFMNSM
MUL_3279|M.ulcerans_Agy99 RYEELLASVSDEPLDVELSPDDLYMLYTGGTTGMPKAVLWRQHDIFMNSM
Mflv_4335|M.gilvum_PYR-GCK DYESIVAEGPAEVPPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMASF
Mvan_2010|M.vanbaalenii_PYR-1 DYESIVAEGPADVPPVEPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF
MAV_1600|M.avium_104 DYEDALASVSAEPPPVRHCPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF
TH_4443|M.thermoresistible__bu DYESIVSNGPADPPPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTAF
MSMEG_3687|M.smegmatis_MC2_155 DYEAILGTPEPEGGMPVPSGDDLYILYTGGTTGMPKGVLWRQHDIFLSSM
MLBr_02546|M.leprae_Br4923 TLAELIARSSSAPAPKVRKRASIIILTSG-TTGTPKGAN-RNTPASLAPL
:. : :: :* *** **.. *: :
Mb3544c|M.bovis_AF2122/97 GGTDFATGEFVKDEYDLAKAAAANPPMI-RYPIPPMIHGATQSATWMALF
Rv3515c|M.tuberculosis_H37Rv GGTDFATGEFVKDEYDLAKAAAANPPMI-RYPIPPMIHGATQSATWMALF
MAB_4163c|M.abscessus_ATCC_199 GGINYVTGEYIEGEWDLAKQGAEAAPFI-GFPIPPMIHGATQAATFMALF
MMAR_2064|M.marinum_M GGRTFGTGELVTGLDDIVERSRQGGPGS--MTVAPLMHGAAQWAAFISLC
MUL_3279|M.ulcerans_Agy99 GGRTFGTGELVTGLDDIVERSRQGGPGS--MTVAPLMHGAAQWAAFISLC
Mflv_4335|M.gilvum_PYR-GCK GGRSLYTGELISSLDDVAQRCVESPGTT-LMVLPPLMHGAAQWAVFTAMN
Mvan_2010|M.vanbaalenii_PYR-1 GGRSLYTGELVSTYDDIAARCSESPGTK-LMVLPPLMHGAAQWAVFTAMN
MAV_1600|M.avium_104 GGRNLMTGEPSSSIDEIVQRAASGPGTK-LMILPPLIHGAAQWSVMTAIT
TH_4443|M.thermoresistible__bu GGRSLYGGEAAGSYGEIAERAAANPGTK-MMILPPLMHGAAQWAAMTALT
MSMEG_3687|M.smegmatis_MC2_155 GGRPFGAENFLSSYEELADKARASAGAMSMLMIPPFMHGAAQWASYTAIT
MLBr_02546|M.leprae_Br4923 GG----------ILSKVPFRAHEVTLLP-----APMFHALGYLHATLAMF
** .: .*::*. ::
Mb3544c|M.bovis_AF2122/97 SGQTTVLAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL--VK
Rv3515c|M.tuberculosis_H37Rv SGQTTVLAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL--VK
MAB_4163c|M.abscessus_ATCC_199 QGRTTVLAP---EFNPEEVWELIEKHKINMLFFAGDAIGRPLIDALDTET
MMAR_2064|M.marinum_M GGRPFVMPQMATRFDPAAAWAMAARERVMSLSIVGDAFGRPLLDELE---
MUL_3279|M.ulcerans_Agy99 GGRPFVMPQMATRFDPAAAWAMAARERVMSLSIVGDAFGRPLLDELE---
Mflv_4335|M.gilvum_PYR-GCK TGQSVVFSPVTEHLDVDDVVATIEREKVLAVTVVGDAMARPLADAFE---
Mvan_2010|M.vanbaalenii_PYR-1 TGQTVVFSPVTSHLDVDDVVATIEREQILAVTVVGDAMARPLAEAFE---
MAV_1600|M.avium_104 TGQTVVFPTVVDHLDAEDVVRTIEREKVMVVTVVGDAMARPLVAAIE---
TH_4443|M.thermoresistible__bu TGQTVVFGSVVDRVDAVDALQTIKREDVSVVTVVGDAIARPLADALE---
MSMEG_3687|M.smegmatis_MC2_155 MGGKLVIPDDVVRLRPDAALRLAERERVMSIPVVGDAIARPLIDEIE---
MLBr_02546|M.leprae_Br4923 LGSTLVLRR---RFKPATVLEDIEKHQATAMVVVPVMLSR-ILDTLEN-L
* *: .. . :. : .. :.* : :
Mb3544c|M.bovis_AF2122/97 GNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT
Rv3515c|M.tuberculosis_H37Rv GNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT
MAB_4163c|M.abscessus_ATCC_199 GRARDLSSLWVLASSAALFSQTVKERYLELLPNRVITDAIGASETGTGGL
MMAR_2064|M.marinum_M SGDYDLSALSVLISGGAALSAGVKQRFVDLLPQLTILDAGGSSESGSQMV
MUL_3279|M.ulcerans_Agy99 SGDYDLSALSVLISGGAALSAGVKQRFVDLLPQLTILDAGGSSESGSQMV
Mflv_4335|M.gilvum_PYR-GCK RTTADLSALAVVANGGAQLTPSAKQRLIDVKKNLMVVDGVGSSETGAQMT
Mvan_2010|M.vanbaalenii_PYR-1 RTSADLSSLAVVANGGAQLTPTAKQRLIDAKQNLMVVDGVGSSETGAQMT
MAV_1600|M.avium_104 KGIADVSSLAVVANGGALLTPFVKQRLIEVLPNAVVVDGVGSSETGAQMH
TH_4443|M.thermoresistible__bu QGVCETPSLAVIANGGAFLTPTTKQRLIDLLPDAIVVDGVGSSETGAQMT
MSMEG_3687|M.smegmatis_MC2_155 GGNYDLSGLVTISNGGAPLSPTVRSRILAALPHLLLLDAVGASESGAQMS
MLBr_02546|M.leprae_Br4923 ETKSDLSSLRVVFVSGSQLGAELATRALEELG-PVIYNMYGSTEIAFATI
: ..* : .: : : : : : *::* .
Mb3544c|M.bovis_AF2122/97 SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVG
Rv3515c|M.tuberculosis_H37Rv SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVG
MAB_4163c|M.abscessus_ATCC_199 STVTKGQMHPGGPTVKISSTTTVLDEEGNPVQPGSGVRGLIAKSGHIPVG
MMAR_2064|M.marinum_M QVSSRVLPAS-GRFDPIPGAVVVSEDLARILTPGDSEIGWLAQQGVIPLG
MUL_3279|M.ulcerans_Agy99 QVSSRVLPAS-GRFDAIPGAVVVSEDLTRILTPGNTCPAGRDTAGHPPLT
Mflv_4335|M.gilvum_PYR-GCK HMSAPGAVST-GKFTAGPDTFVASEDLSTILEPGHDGMGWLAQRGYVPLG
Mvan_2010|M.vanbaalenii_PYR-1 HMSAPGAVST-GKFNAGPDTFVAAEDLGSILEPGHDGIGWLAQRGYVPLG
MAV_1600|M.avium_104 HMSTPGAVAT-GTFNAGPDTFVAAEDLSAILPPGHEGMGWLAQRGYVPLG
TH_4443|M.thermoresistible__bu HMSMNGAVAT-GTFNPGPDTCVLAEDFSTVLPPGHAGLGWLGQRGYVPLG
MSMEG_3687|M.smegmatis_MC2_155 AYTTSGAETQPATFTPQPDTAVVSEDLTRVLGPG-EGGGWLARRDLIPLG
MLBr_02546|M.leprae_Br4923 AGPKDLQINSATVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEG
. : *
Mb3544c|M.bovis_AF2122/97 YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGE
Rv3515c|M.tuberculosis_H37Rv YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGE
MAB_4163c|M.abscessus_ATCC_199 YFKDEKKTAETFKTFNGVRYAIPGDWATVEADGTVTMLGRGSVSINTGGE
MMAR_2064|M.marinum_M YLGDKAKTARTFPVIEGIRHSVPGDRARWDADGTIELLGRDSVTINSGGE
MUL_3279|M.ulcerans_Agy99 ICGTGDLSLSRLPIAP--------DRGCGDS-------WSAACLVRSG--
Mflv_4335|M.gilvum_PYR-GCK YKGDATKTAATFPVIEGVRYSVPGDRARHLADGAVELLGRDSVTINSGGE
Mvan_2010|M.vanbaalenii_PYR-1 YKGDAAKTAATFPVIGGVRYSVPGDRARHLADGAVELLGRDSVTINSGGE
MAV_1600|M.avium_104 YKGDAAKTAKTFPVIDGVRYAVPGDRARHHADGHIELLGRDSVCINSGGE
TH_4443|M.thermoresistible__bu YKGDADKTARTFPVIDTVRYAVPGDRARHLDGGAIELLGRDSVTINSGGE
MSMEG_3687|M.smegmatis_MC2_155 YLGDAEKTARTFPTVDGVRWSVPGDRANVLPDGRIQLLGRDSVTINSGGE
MLBr_02546|M.leprae_Br4923 YTGGGGK-----QIIDGLLSS--GDVGYFDEHDLLYISGRDDEMIVSGGE
* . : :*
Mb3544c|M.bovis_AF2122/97 KVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE
Rv3515c|M.tuberculosis_H37Rv KVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE
MAB_4163c|M.abscessus_ATCC_199 KVFPEEVESVLKGHPAVFDAVVVGVPDEKWGQHVGAVIAVREGVELTFED
MMAR_2064|M.marinum_M KIFVEEVEAAIAEHPAVYDVVVTGRPSPRWGNEVVAIVQLAEGAAPDPDS
MUL_3279|M.ulcerans_Agy99 ----------VGEG-------LAGQPN-----------------FPDART
Mflv_4335|M.gilvum_PYR-GCK KIFAEEVESAIASHPAVADVVVAGRPSERWGQEVVAVVALDSGATATAEE
Mvan_2010|M.vanbaalenii_PYR-1 KIFAEEVESAIASHPAVADVVVAGRPSDRWGQEVVAVVALADGAQATADE
MAV_1600|M.avium_104 KIFVEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALSDGAAVDAGE
TH_4443|M.thermoresistible__bu KIFAEEVEMALASHPAVADVVVTGRPSDRWGQEVVAVVALAEGATADAEA
MSMEG_3687|M.smegmatis_MC2_155 KIFVEEVERAIAAHPAVYDVVVVGRPSERWGSEVVAIVQFAEGASATDDE
MLBr_02546|M.leprae_Br4923 NVFPAEVEDLISGHPEVVEATAIGVDDKEWGARLRAFVVKKQDATIDEDA
: * .
Mb3544c|M.bovis_AF2122/97 LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVH
Rv3515c|M.tuberculosis_H37Rv LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVH
MAB_4163c|M.abscessus_ATCC_199 LDAHARKEIAGYKVPRSIWIVDSVKRNPAGKADYRWAKEVSETEKVDLVN
MMAR_2064|M.marinum_M IIGEAARHIARYKLPKEIVFCPKVQRSPAGKPDYRWAKATVAPQD-----
MUL_3279|M.ulcerans_Agy99 LLGEYPLCYS----------------------------------------
Mflv_4335|M.gilvum_PYR-GCK LIDHASAVIARYKLPKAVVFRPAIERSPAGKADYRWAREQAISGS-----
Mvan_2010|M.vanbaalenii_PYR-1 LVEHASSVIARYKLPKAVVFRPVIERSPAGKADYRWAREQAISGS-----
MAV_1600|M.avium_104 LIAHASNSLARYKLPKAIVFRPVIERSPSGKADYRWAREQAVDG------
TH_4443|M.thermoresistible__bu LIEHAAGALARYKLPKAIVFRPVIQRSPAGKADYRWAREQATASVAAE--
MSMEG_3687|M.smegmatis_MC2_155 LVEVCERSIARYKIPKAFIRSPEIVRSPAGKADYRWAKQIATEAVST---
MLBr_02546|M.leprae_Br4923 IKAYVRDHLARYKVPREVIFLEELPRNPTGKVLKRELRDFEVH-------
: :
Mb3544c|M.bovis_AF2122/97 AGHVTSGG
Rv3515c|M.tuberculosis_H37Rv AGHVTSGG
MAB_4163c|M.abscessus_ATCC_199 SKHVNTGA
MMAR_2064|M.marinum_M --------
MUL_3279|M.ulcerans_Agy99 --------
Mflv_4335|M.gilvum_PYR-GCK --------
Mvan_2010|M.vanbaalenii_PYR-1 --------
MAV_1600|M.avium_104 --------
TH_4443|M.thermoresistible__bu --------
MSMEG_3687|M.smegmatis_MC2_155 --------
MLBr_02546|M.leprae_Br4923 --------