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MGEWTIGGVVDAIAEAVPDRLMTVCGERRSTYRQTADRTRRFANFLSANGIGAHQERDALQGWECGQDRV ALIMHNDLYPDMVIGSLKARAVPVNVNFNYTPREVDELLSYLRPRAVVFHRSLGAKFADVLPREGVDLMI SIDDGSGAPELTGAVRLDDALAAGETDQHITPSPDDVMMICTGGTTGRPKGVMWRQSDTYVVSMNGADHE SVAEIHDKVQHAGPPWFAVSPLMHAAGMWTAFAALLNGQTVILYDKPTLDSATVLSTAEREKVGLMTMVG DAYAGPLIDELRRRPYDLSSLFAIGTGGAATNQRHQEALLELLPQITLINGYGSSETGNMAFGRSQADDR KDTFERRGGVVLLSEDHSRILQPGDQEVGWVAREGRIPLGYFDDAEATRRTFPQVEGRRVVISGDRASLE PDGTLRLYGRDSLVVNTGGEKVFVEEVEEVLRAHGGVADALVVGRDSDRWGQEIVALIEKAPGADVESEA LLLVCNSALARFKAPKEFIFVDKVRRLGNGKADYRWAKSQATQRDTVVGQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1995 | - | - | 100% (541) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2010 | - | e-106 | 39.19% (541) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_5215 | - | 3e-78 | 34.24% (549) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3544c | fadD19 | 5e-83 | 36.15% (545) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4349 | - | 0.0 | 86.99% (538) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3515c | fadD19 | 6e-83 | 36.15% (545) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-22 | 23.11% (515) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4163c | - | 9e-80 | 34.81% (540) | acyl-CoA synthetase |
| M. marinum M | MMAR_4013 | - | 0.0 | 65.13% (542) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_1592 | - | 0.0 | 70.92% (533) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_2231 | - | 0.0 | 71.43% (539) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4377 | - | 0.0 | 72.24% (544) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3870 | fadD19_2 | 1e-106 | 39.85% (542) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3544c|M.bovis_AF2122/97 ----------------------------MAVALNIADLAEHAIDAVPDRV
Rv3515c|M.tuberculosis_H37Rv ----------------------------MAVALNIADLAEHAIDAVPDRV
MAB_4163c|M.abscessus_ATCC_199 ------------------------------MALNIADLIEHAIDTMPDRV
Mvan_1995|M.vanbaalenii_PYR-1 -----------------------------MGEWTIGGVVDAIAEAVPDRL
Mflv_4349|M.gilvum_PYR-GCK -----------------------------MPEWTIGGVVDAIAEAIPDRL
TH_4377|M.thermoresistible__bu -----------------------------MGEWTIGAVLDAIAEAVPDRP
MSMEG_2231|M.smegmatis_MC2_155 -----------------------------MPEWTIGGVVDAIAEAVPDRE
MAV_1592|M.avium_104 -----------------------------MSEWTIGAVLDEIADVIPDRT
MMAR_4013|M.marinum_M ---------------------------MAVTEWTIGAVLDAIAEVVPDRP
MUL_3870|M.ulcerans_Agy99 ----------------------------MTTQFTVPAVASAVTAAIGDRE
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
. :
Mb3544c|M.bovis_AF2122/97 AVICGDEQLTYAQLEDKANRLAHHLIDQGVQKD-------------DKVG
Rv3515c|M.tuberculosis_H37Rv AVICGDEQLTYAQLEDKANRLAHHLIDQGVQKD-------------DKVG
MAB_4163c|M.abscessus_ATCC_199 AIISGDRKLTYAELEEQSNRLGHYLQSQGVGPG-------------DKVG
Mvan_1995|M.vanbaalenii_PYR-1 MTVCGERRSTYRQTADRTRRFANFLSANGIGAHQERDALQGWECGQDRVA
Mflv_4349|M.gilvum_PYR-GCK MTVCGSRRSTYAETAERTRRVANFLSANGIGAHQERDTIDGWQCGQDRVA
TH_4377|M.thermoresistible__bu MTVCGGRRSTFAETADRTRRLANFLAAHGFGAHRERAELANWECGQDRVA
MSMEG_2231|M.smegmatis_MC2_155 MTVCGARRTTFAQGADRTRRIANFLAGQGLGAHRERRELNRWECGQDRVA
MAV_1592|M.avium_104 MTVCGDRRSTFAESADRTRRLANFLSGNGLGVHRERAVLQNWECGQDRVA
MMAR_4013|M.marinum_M MTVCGPRRTSFAEAAQRTSRLASYLNKQGFGAHRARETLQRWECGQDRVA
MUL_3870|M.ulcerans_Agy99 LVVQGDRRHTYRQIHQRSNRLASYLHSQGLGCHTERSELAGHEVGQNLLG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
.: .. . . : :.
Mb3544c|M.bovis_AF2122/97 LYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMVALVHE
Rv3515c|M.tuberculosis_H37Rv LYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMVALVHE
MAB_4163c|M.abscessus_ATCC_199 LYCRNGIEIVIALTAIVKIRAISVNVNYRYVEAELHYLFENSDMAALVHE
Mvan_1995|M.vanbaalenii_PYR-1 LIMHN-DLYPDMVIGSLKARAVPVNVNFNYTPREVDELLSYLRPRAVVFH
Mflv_4349|M.gilvum_PYR-GCK LIMHN-DLYPDMVIGALKARAVPVNVNFNYTPREVDELLAYLRPRAVIFH
TH_4377|M.thermoresistible__bu LIMHN-DLYPDMVIGCLKARTVPVNVNYHYTPREVADLLAYVKPRAVIYH
MSMEG_2231|M.smegmatis_MC2_155 LIMHN-DQYPDLVIGCLKARTVPVNVNYYYSPREVAELLDHLRPSAAVYH
MAV_1592|M.avium_104 LVMHN-DLYPDMVVGCLKARTVPVNVNYHYTPREVGELFDYLRPRAVIYH
MMAR_4013|M.marinum_M LIMHN-DLYPDMVIGCLKARVVPVNVNHHYSPREIAELLEYVRPRGIIYH
MUL_3870|M.ulcerans_Agy99 IYAYNGNEFVEALFGSFAARVAPFNVNFRYVKNEPQYLLADAGATALIYH
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
: * . . . :* : : : :..
Mb3544c|M.bovis_AF2122/97 RRYADRVANVLPDTPHVRTILVVEDGS--------DQDYRRYGGVEFYSA
Rv3515c|M.tuberculosis_H37Rv RRYADRVANVLPDTPHVRTILVVEDGS--------DQDYRRYGGVEFYSA
MAB_4163c|M.abscessus_ATCC_199 RRYSDKVANVLPSTPNVKTAIVVEDGA--------DGSFDSYGGVPFADA
Mvan_1995|M.vanbaalenii_PYR-1 RSLGAKFADVLPRE-GVDLMISIDDG---------SGAPELTGAVRLDDA
Mflv_4349|M.gilvum_PYR-GCK RSLGAKFADVLPRT-GVEVMISIDDG---------SDAPELTGAVTLDDA
TH_4377|M.thermoresistible__bu RSLGAKFAGVLPPS-GAELLIAIDDGPEGSDGSDCSNGVGLSGAIDLEDA
MSMEG_2231|M.smegmatis_MC2_155 RSLGAKFADVLPPR-SARLLICVDDG----------PGPDLPGAIPLDDA
MAV_1592|M.avium_104 RGLGPKFADVLGRG-DVDLLIAVDDG---------SEAPQLPGAVSLNDA
MMAR_4013|M.marinum_M RALGARFADLLPAA-GADLLVSIDDG---------SGAAELPGAVSLDEV
MUL_3870|M.ulcerans_Agy99 ATFAPRVAEVLPELPRLRVLIQIADD---------SGNGLLDGAVDYESI
MLBr_02546|M.leprae_Br4923 DEYTKVVSKAEPALGKLRALGVNPDE----------EEPPGSTDETLAEL
.: * .
Mb3544c|M.bovis_AF2122/97 IAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDF
Rv3515c|M.tuberculosis_H37Rv IAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDF
MAB_4163c|M.abscessus_ATCC_199 LAQGSPERDFEERSPDDIFLIYTGGTTGFPKGVMWRHEDIYRSLFGGINY
Mvan_1995|M.vanbaalenii_PYR-1 LAAGETD-QHITPSPDDVMMICTGGTTGRPKGVMWRQSDTYVVSMNGADH
Mflv_4349|M.gilvum_PYR-GCK LAAGDAD-QPITPSPDDVMMICTGGTTGRPKGVMWRQSDTYVVSMNGADH
TH_4377|M.thermoresistible__bu LAQGDVD-QPITPSPDDVLMICTGGTTGRPKGVMWRQSDTYTVSMNGADH
MSMEG_2231|M.smegmatis_MC2_155 LAQSGSD-CVAPASPDDLLMICTGGTTGRPKAVMWRQGDIYVSSMNGADH
MAV_1592|M.avium_104 LAQGDTG-HPVPGSPDDLLMICTGGTTGRPKGVLWRQSDIYVSSMVGADH
MMAR_4013|M.marinum_M VTAGAPN-YRPTGSPDDLIMMCTGGTTGRPKGVLWRQGDMYVASMVGADH
MUL_3870|M.ulcerans_Agy99 IANSSPEPLPVQPSPDDLYVLYTGGTTGMTKGVLWRQHDIFMTSFGGRDL
MLBr_02546|M.leprae_Br4923 IARSSSAPAPKVRKRASIIILTSG-TTGTPKGAN-RNTPASLAPLGG---
:: . . : :: :* *** .*.. *: : *
Mb3544c|M.bovis_AF2122/97 ATGEFVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFSGQTTV
Rv3515c|M.tuberculosis_H37Rv ATGEFVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFSGQTTV
MAB_4163c|M.abscessus_ATCC_199 VTGEYIEGEWDLAKQGAEAAPFIGFPIPPMIHGATQAATFMALFQGRTTV
Mvan_1995|M.vanbaalenii_PYR-1 ES------VAEIHDKVQ-HAGPPWFAVSPLMHAAGMWTAFAALLNGQTVI
Mflv_4349|M.gilvum_PYR-GCK ES------VDEIHAKVQ-HAGPPWFAVSPLMHAAGMWTAFAALLNGQTVI
TH_4377|M.thermoresistible__bu DS------VDEIHDKVR-HAGPPWFAVSPLMHAAGMWTAFAGALSGQTVV
MSMEG_2231|M.smegmatis_MC2_155 DD------ASEIHAKVA-NAGPPWFAVSPLMHAAGLWTAFSGLLSGQTVV
MAV_1592|M.avium_104 AC------AQEIRDKVSGAAGAPWFAVSPLMHAAGMWTAFAAIMSGTTVV
MMAR_4013|M.marinum_M AN------VDEIHQKVR-LGGSPWFAVSPLMHAAGLWTAFSGFLSGFPVV
MUL_3870|M.ulcerans_Agy99 YSGQPVNSVDEIVARTTAGPGTKLLVLPPLIHGAAQWTVMTALTTGQTVV
MLBr_02546|M.leprae_Br4923 -----------ILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLGSTLV
: .*::*. . . * . :
Mb3544c|M.bovis_AF2122/97 LAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL--VKGNDYDL
Rv3515c|M.tuberculosis_H37Rv LAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL--VKGNDYDL
MAB_4163c|M.abscessus_ATCC_199 LAP---EFNPEEVWELIEKHKINMLFFAGDAIGRPLIDALDTETGRARDL
Mvan_1995|M.vanbaalenii_PYR-1 LYD-KPTLDSATVLSTAEREKVGLMTMVGDAYAGPLIDELR---RRPYDL
Mflv_4349|M.gilvum_PYR-GCK LYD-KPTLDAAAVLETAEREKVGLMTMVGDAYARPLIAELQ---RRPYDL
TH_4377|M.thermoresistible__bu LYD-STRFDARRVLRTAEREKVGLMTMVGDAYAGPLVAEMR---QHRYDL
MSMEG_2231|M.smegmatis_MC2_155 LHDTKPRFDPRAVLETAEREKVGLMTMVGDAYAAPIVEELR---RRTYDL
MAV_1592|M.avium_104 LYDTGKKLDPRSVWETAQRERVGMMTMVGDAYAAPLVAELR---RGSYDL
MMAR_4013|M.marinum_M LYDDRAKLDVRSVWATAEREKVGMVTMVGDAYAGPLVAELS---AHPYDL
MUL_3870|M.ulcerans_Agy99 FASVVDHLDPRDVVRTIERERVSVVTVVGNAIARPLVASIE---KGTADV
MLBr_02546|M.leprae_Br4923 LRR---RFKPATVLEDIEKHQATAMVVVPVMLSRILDTLEN--LETKSDL
: :. * .:.: : .. . : *:
Mb3544c|M.bovis_AF2122/97 SSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSVVAAG
Rv3515c|M.tuberculosis_H37Rv SSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSVVAAG
MAB_4163c|M.abscessus_ATCC_199 SSLWVLASSAALFSQTVKERYLELLPNRVITDAIGASETGTGGLSTVTKG
Mvan_1995|M.vanbaalenii_PYR-1 SSLFAIGTGGAATNQRHQEALLELLPQITLINGYGSSETGNMAFGRSQAD
Mflv_4349|M.gilvum_PYR-GCK SSLFAIGTGGAATNQRHQDALLELLPQITLINGYGSSETGNMAFGRSLRD
TH_4377|M.thermoresistible__bu SALFAVAAGGAATNPKHQRALLDMLPQITFINGYGSSETGNVGFGRSQRG
MSMEG_2231|M.smegmatis_MC2_155 SSLFAIGTGGAATNLKHQQALLDHIPQITLINGFGSSETGNMGFGHSQRG
MAV_1592|M.avium_104 SSLYAIGTGGAATNAKYQQALLELLPHITLINGYGSSETGNMGFGHSRTG
MMAR_4013|M.marinum_M SALQAIGTGGAATNPKYKRALMERLPHVTIIEGYGSSETGNMAFGHSRNR
MUL_3870|M.ulcerans_Agy99 SSLVAVANGGALLTPYVKQRLIAALPNAVIIDGVGSSETGAQMHHLSASG
MLBr_02546|M.leprae_Br4923 SSLRVVFVSGSQLGAELATRALEELG-PVIYNMYGSTEIAFATIAGPKDL
*:* : .: : : .: : *::* .
Mb3544c|M.bovis_AF2122/97 QAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEK
Rv3515c|M.tuberculosis_H37Rv QAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEK
MAB_4163c|M.abscessus_ATCC_199 QMHPGGPTVKISSTTTVLDEEGNPVQPGSGVRGLIAKSGHIPVGYFKDEK
Mvan_1995|M.vanbaalenii_PYR-1 DRKD--TFERRGGVVLLSEDHSRILQPGDQEVGWVAREGRIPLGYFDDAE
Mflv_4349|M.gilvum_PYR-GCK DRKD--TFERRDGVVLLSEDRTRFLEPGEDEIGWVAREGRIPLGYFDDAD
TH_4377|M.thermoresistible__bu DEKE--TFELRDGALVVAEDYGRFLEPGETQIGWVARAGRIPLGYFDDPE
MSMEG_2231|M.smegmatis_MC2_155 NQAE--TFQLRAGGLVLAEDHSRFLTPGEQGVGWVARNGRIPLGYFDDEA
MAV_1592|M.avium_104 TRTD--TFTLREGGLVLAEDYSRFLSPGEPQLGWVAREGRIPLGYFDDPD
MMAR_4013|M.marinum_M MASE--TFAMRVGGAVASADRSSFLQPGTAEIGWAARMGRIPLGYFNDPE
MUL_3870|M.ulcerans_Agy99 AISTG-TFNAGPDINVAAEDLSAILPAGHEGIGWLAQRGYVPLGYKGDAA
MLBr_02546|M.leprae_Br4923 QINSATVGPVVKGVKVKILDDSGKEVP-RGQVGRIFVGNAFPFEGYTGGG
: . * . .*. .
Mb3544c|M.bovis_AF2122/97 KTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEE
Rv3515c|M.tuberculosis_H37Rv KTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEE
MAB_4163c|M.abscessus_ATCC_199 KTAETFKTFNGVRYAIPGDWATVEADGTVTMLGRGSVSINTGGEKVFPEE
Mvan_1995|M.vanbaalenii_PYR-1 ATRRTFPQVEGRRVVISGDRASLEPDGTLRLYGRDSLVVNTGGEKVFVEE
Mflv_4349|M.gilvum_PYR-GCK ATARTFPVVDGRRVVISGDRASLEADGTIRLYGRDSLVINTGGEKVFVEE
TH_4377|M.thermoresistible__bu GTSRTFPEVQGRRVVISGDRGSLAPDGTLVLYGRDSLVVNTGGEKVFVEE
MSMEG_2231|M.smegmatis_MC2_155 ATANTFPEVEGQRVVVSGDRAALEADGTLRLYGRDSLVVNTGGEKVFVEE
MAV_1592|M.avium_104 ATRKTFPVIDGKQVVISGDRAALEPDGTLRLFGRDSLVVNTGGEKVFVEE
MMAR_4013|M.marinum_M ATRRTFPEIEGHRVVIPGDRATIENDGTIRLLGRDSLVVNTGGEKVFVEE
MUL_3870|M.ulcerans_Agy99 KTATTFPVINGVRYAVPGDRARHRADGCIELLGRDSATINSGGEKIFAEE
MLBr_02546|M.leprae_Br4923 GKQ----IIDG--LLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAE
. .:* .** . .. : : **.. : :***::: *
Mb3544c|M.bovis_AF2122/97 VEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPG----CRPSLAELD
Rv3515c|M.tuberculosis_H37Rv VEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPG----CRPSLAELD
MAB_4163c|M.abscessus_ATCC_199 VESVLKGHPAVFDAVVVGVPDEKWGQHVGAVIAVREG----VELTFEDLD
Mvan_1995|M.vanbaalenii_PYR-1 VEEVLRAHGGVADALVVGRDSDRWGQEIVALIEKAP--GADVES--EALL
Mflv_4349|M.gilvum_PYR-GCK VEEVLRAHHGVADALVIGRDSDRWGQEIVALVQKQP--DAVVDP--SALL
TH_4377|M.thermoresistible__bu VEEVLRAHPGIVDALVVGRPSERWGQEVVALVALRG--DSERDSSPSALH
MSMEG_2231|M.smegmatis_MC2_155 VEEVLRAHAAVADALVVGRPSERWGEEIVAIVALRDNHGSDHDVTGEALR
MAV_1592|M.avium_104 VEEVLRAHPAVADALVVGRPSGRWGEEIVALVELRAGTGAAADE----LH
MMAR_4013|M.marinum_M VEEVLRGHPDIADALVVGRASQRWGQEVVALVAARP--GVDLAGSERALY
MUL_3870|M.ulcerans_Agy99 VETAIASHPAVADVVVAGRPSERWGQEVVAVVALDP--DAAADA--EELV
MLBr_02546|M.leprae_Br4923 VEDLISGHPEVVEATAIGVDDKEWGARLRAFVVKKQD----ATIDEDAIK
** : .* : :. . * . .:* .: *.: :
Mb3544c|M.bovis_AF2122/97 SFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAG
Rv3515c|M.tuberculosis_H37Rv SFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAG
MAB_4163c|M.abscessus_ATCC_199 AHARKEIAGYKVPRSIWIVDSVKRNPAGKADYRWAKEVSETEKVDLVNSK
Mvan_1995|M.vanbaalenii_PYR-1 LVCNSALARFKAPKEFIFVDKVRRLGNGKADYRWAKSQATQRDTVVGQS-
Mflv_4349|M.gilvum_PYR-GCK DACHEALARYKAPKEFLFVDRVRRLGNGKADYRWAKSQVAPQDTLAGQP-
TH_4377|M.thermoresistible__bu AHCTAALAGFKTPKEFITVDEIRRLGNGKADYRWAREVAVQSAMRMA---
MSMEG_2231|M.smegmatis_MC2_155 EHCSTRLARFKTPKDVMFVEQVRRLGNGKADYRWAKAHAAQRVEMA----
MAV_1592|M.avium_104 AHCTSRLARFKAPKEFLFVAAVQRLGNGKADYRWAKRHAVTEASEKAPMS
MMAR_4013|M.marinum_M ALCTAKLAHFKAPKAFIFVSHIQRLGNGKPNYRWAKQAAAQQLPVGGSA-
MUL_3870|M.ulcerans_Agy99 AHAAKSLARYKLPKAIVFRAGIQRSPSGKADYRWAKEQAADG--------
MLBr_02546|M.leprae_Br4923 AYVRDHLARYKVPREVIFLEELPRNPTGKVLKRELRDFEVH---------
:* :* *: . : * ** * :
Mb3544c|M.bovis_AF2122/97 HVTSGG
Rv3515c|M.tuberculosis_H37Rv HVTSGG
MAB_4163c|M.abscessus_ATCC_199 HVNTGA
Mvan_1995|M.vanbaalenii_PYR-1 ------
Mflv_4349|M.gilvum_PYR-GCK ------
TH_4377|M.thermoresistible__bu ------
MSMEG_2231|M.smegmatis_MC2_155 ------
MAV_1592|M.avium_104 T-----
MMAR_4013|M.marinum_M ------
MUL_3870|M.ulcerans_Agy99 ------
MLBr_02546|M.leprae_Br4923 ------