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MTELVAAAAVPPAVRLPPEFRMPKALQAITYVALRRWLLLRLARRYGKVFSVNLPLYGHIVVVGDCLLAK QVLATSPEELGNIEPNLGRLFGPGSIFSLDGEEHRQRRRLLMPLFHGNLMKSYESIIEDETLREVANWPE GQSFPAMPAMAQITLGGILRALFGPECAELDELRRLVPPWVTLGLRIALLPRPRRDYGRYSPWARLAEMR HQCEIVIEKLIEAARTGPNLAERTDVLALMLRSCYDDGSAMSHNDIVDELLTMMAAGHETTAATLTWAFE RLGRHPDVLAALVEEADRGGRALRQATILEVQRTRPAIDRVVRRVCSPYYRLGQWVLPQGYSVHLHIEQV QSDPEIFPDPERFDPHRHMGGKPSSLGWIPFGGGTRRCIGAALANLEIDVVLRTVLRNFTIEPNAAPDER WHNRGIAFTPKDGGQIVVHRRH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3976 | cyp138A4 | - | 100% (442) | cytochrome P450 138A4 Cyp138A4 |
| M. marinum M | MMAR_0346 | cyp138A3 | e-166 | 61.90% (441) | cytochrome P450 138A3 Cyp138A3 |
| M. marinum M | MMAR_4430 | cyp138B1 | e-103 | 46.56% (436) | cytochrome P450 138B1 Cyp138B1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0141 | cyp138 | 1e-175 | 65.76% (441) | cytochrome P450 138 |
| M. gilvum PYR-GCK | Mflv_1104 | - | 1e-143 | 56.31% (428) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0136 | cyp138 | 1e-175 | 65.76% (441) | cytochrome P450 138 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-14 | 24.07% (349) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1427c | - | 1e-144 | 56.32% (435) | putative cytochrome P450 |
| M. avium 104 | MAV_5160 | - | 1e-166 | 64.37% (435) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_6478 | - | 1e-141 | 53.85% (429) | putative cytochrome P450 135B1 |
| M. thermoresistible (build 8) | TH_0082 | - | 1e-150 | 56.53% (444) | putative cytochrome P450 135B1 |
| M. ulcerans Agy99 | MUL_0473 | cyp51B1 | 6e-26 | 26.68% (401) | cytochrome P450 51B1 Cyp51B1 |
| M. vanbaalenii PYR-1 | Mvan_5712 | - | 1e-149 | 57.34% (436) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1104|M.gilvum_PYR-GCK -------------------------MRLPPTPRIPRFLQG--LGFSLSRQ
Mvan_5712|M.vanbaalenii_PYR-1 ---MSEATIAAHRSTADAESAPPRPVRLPPTPRIPKLLQG--LGFSFSRQ
MSMEG_6478|M.smegmatis_MC2_155 -----------MTATVERPESAIRAAQLPPVLPLPKTVQG--LAFSVARR
TH_0082|M.thermoresistible__bu ---------MTEATIAPDVDHAVRSQKLPPAVPLPKSLQG--IAFIASRR
MAB_1427c|M.abscessus_ATCC_199 -----MEGDVTEISTIDRAADVPKP-IAPPLVTLPKLAQG--IAFVASRR
Mb0141|M.bovis_AF2122/97 ------------MSEVVTAAPAPPVVRLPPAVRGPKLFQG--LAFVVSRR
Rv0136|M.tuberculosis_H37Rv ------------MSEVVTAAPAPPVVRLPPAVRGPKLFQG--LAFVVSRR
MAV_5160|M.avium_104 ------------MSEVATAPLA--AVHLPPAVRGPKLLQG--IGFAVSRR
MMAR_3976|M.marinum_M ------------MTELVAAAAVPPAVRLPPEFRMPKALQA--ITYVALRR
MUL_0473|M.ulcerans_Agy99 -----------------------MTTAIVPRVSGGEEEHGHLEEFRTDPI
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
.
Mflv_1104|M.gilvum_PYR-GCK WTVAQVVRRYGDVFTMTLPVFGKTVLVTDPALAKQLFMANTDDVGNIQPN
Mvan_5712|M.vanbaalenii_PYR-1 WTVAQIVRRYGDVFSMTLPVFGPTVMVADPALAKQLFMANTDDVGNIQPN
MSMEG_6478|M.smegmatis_MC2_155 WVVKQAARRYGDVVTLDIPVFGRTVLVTEPQLAKQVYAAHPDDVGNVQPN
TH_0082|M.thermoresistible__bu WTLTTATRRYGDVFRLNIPVFGRTVVVSDPVLAKQVFSANPDDVGNIQPN
MAB_1427c|M.abscessus_ATCC_199 WTTSRLAKKYGKVYTINIPKFGYTVVVADPDLTREVFTTSTEILGNIQPN
Mb0141|M.bovis_AF2122/97 RLLGRFVRRYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPN
Rv0136|M.tuberculosis_H37Rv RLLGRFVRRYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPN
MAV_5160|M.avium_104 TMMRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQIFTTSPDELGNIQPN
MMAR_3976|M.marinum_M WLLLRLARRYGKVFSVNLPLYGHIVVVGDCLLAKQVLATSPEELGNIEPN
MUL_0473|M.ulcerans_Agy99 GLMQRVRDECGDVGWFQLANK-HVVLLSGAKANEFFFRSSDEELDQAEAY
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
* : . . :
Mflv_1104|M.gilvum_PYR-GCK ------LSRVLGSGSVFALDGTDHRLRRKLLTPPFHGKSIKNYERIFEEE
Mvan_5712|M.vanbaalenii_PYR-1 ------LSRVLGSGSVFALDGGDHRKRRKLLTPPFHGKSIKNYETIFEEE
MSMEG_6478|M.smegmatis_MC2_155 ------LSRMLGPGSVFALDGTDHRRRRKLLTPPFHGRSIKNYERIFEEE
TH_0082|M.thermoresistible__bu ------LSRVLGPGSVFALDGAEHRRRRKLLTPPFHGKSIKNYEKIFEEE
MAB_1427c|M.abscessus_ATCC_199 ------LSQQLGPGSVFALERNEHRHRRKLLAPKFHGKAMVQYEQIIEEE
Mb0141|M.bovis_AF2122/97 ------LSRMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEE
Rv0136|M.tuberculosis_H37Rv ------LSRMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEE
MAV_5160|M.avium_104 ------LSRLFGSGSVFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIEEE
MMAR_3976|M.marinum_M ------LGRLFGPGSIFSLDGEEHRQRRRLLMPLFHGNLMKSYESIIEDE
MUL_0473|M.ulcerans_Agy99 PF----MTPIFGKGVVFDASPE--RRKEMLHNSALRGEHMKGHATTIERE
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
: . .: . . * : . : :
Mflv_1104|M.gilvum_PYR-GCK TLREAASWPEGQPFETLEPMMRITLNAILRAVFGADGAHLDELRRIIPPW
Mvan_5712|M.vanbaalenii_PYR-1 TLREAANWPEGQPFETLEPMMRITLNAILRAVFGADGAHLDELRRIIPPW
MSMEG_6478|M.smegmatis_MC2_155 TLREAASWPDGQEFRTLEPMMRITLNVILRAVFGADGEQLDELRRIIPPW
TH_0082|M.thermoresistible__bu TLAEAANWPEGREFPTLEPMMRITLNAILRAVFGAEGEHLDELRRIIPPW
MAB_1427c|M.abscessus_ATCC_199 TLRECATWPEGQQFETMEPMMRITLNAILRAVFGADGAELDVLRRLIPPW
Mb0141|M.bovis_AF2122/97 TLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGSELDELRRLIPPW
Rv0136|M.tuberculosis_H37Rv TLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGSELDELRRLIPPW
MAV_5160|M.avium_104 TLRETAGWPEGESFPTLPPMMRITLNAILRAVFGAEGAELDELRRLIPPW
MMAR_3976|M.marinum_M TLREVANWPEGQSFPAMPAMAQITLGGILRALFGPECAELDELRRLVPPW
MUL_0473|M.ulcerans_Agy99 VHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFR--NQLDSRFAHF
MLBr_02088|M.leprae_Br4923 VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRVSALL
. : : : ::* : .
Mflv_1104|M.gilvum_PYR-GCK VTLGSRLAVLPTPHRTYGRFSPWGRLARYRRRYDEVIGRLIDAVQADPNF
Mvan_5712|M.vanbaalenii_PYR-1 VTLGSRLAVLPTPHRTYGRFSPWGRLAAYRRQYDDVIGRLIDAVQADPDF
MSMEG_6478|M.smegmatis_MC2_155 VTLGSRLAVLPTPKRNYGRLTPWGRLAAYRAEYDDVVDRLIDRVEADPDF
TH_0082|M.thermoresistible__bu VTLGSRVATLPTPSRNYGRFSPWGRLAAYRRCYDEVIGRLIDKVQADPHF
MAB_1427c|M.abscessus_ATCC_199 VVLASLTTRIPQPKRNYGRFSPWGRLKTYRAHYDAVIGSLIEKALAAPDF
Mb0141|M.bovis_AF2122/97 VTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVIDKLIEAERADPNF
Rv0136|M.tuberculosis_H37Rv VTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVIDKLIEAERADPNF
MAV_5160|M.avium_104 VTLGSRLAALPKPQR-YPRFGPWGQLDRWRRQYDGVIERLIAAEQADPNF
MMAR_3976|M.marinum_M VTLGLRIALLPRPRRDYGRYSPWARLAEMRHQCEIVIEKLIEAARTGPNL
MUL_0473|M.ulcerans_Agy99 CHELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQRVANPPT
MLBr_02088|M.leprae_Br4923 VQSVDPFITITGEPPEATEERLRAG-----VWLRDYLEQLVKCRRGTPGE
: :: *
Mflv_1104|M.gilvum_PYR-GCK ESRD-DVLALLLRSTYEDGSS-MSRQDIGDELLTLLAAGHETTAATLGWV
Mvan_5712|M.vanbaalenii_PYR-1 DTRD-DILALLLRSTYEDGST-MSRQDIGDELLTLLAAGHETTAATLGWA
MSMEG_6478|M.smegmatis_MC2_155 DQRD-DILALLLRSAYEDGSS-MSRKDIGDELLTLLAAGHETTASTLGWA
TH_0082|M.thermoresistible__bu EERD-DVLALLLRSTYEDGTA-MTRQDIADELLTLLAAGHETTASTMGWV
MAB_1427c|M.abscessus_ATCC_199 EDRT-DILALLLRSTYDDGTT-MSRSDVSDELLTLLAAGHETTATTLAWA
Mb0141|M.bovis_AF2122/97 ADRT-DVLALMLRSTYDDGSI-MSRKDIGDELLTLLAAGHETTAATLGWA
Rv0136|M.tuberculosis_H37Rv ADRT-DVLALMLRSTYDDGSI-MSRKDIGDELLTLLAAGHETTAATLGWA
MAV_5160|M.avium_104 AERT-DVLALLLRSTYDDGAA-MSHKEIGDELLTLLAAGHETTASTLAWA
MMAR_3976|M.marinum_M AERT-DVLALMLRSCYDDGSA-MSHNDIVDELLTMMAAGHETTAATLTWA
MUL_0473|M.ulcerans_Agy99 DKRDRDMLDVLVSITDEQGNPRFCTDEVTGMFISLMFAGHHTSSGTSAWT
MLBr_02088|M.leprae_Br4923 -----DLISRLIELD-ESGDQ-LTEEEIIATCGLLLVAGHETTVNLIANA
*:: :: :.* : .:: :: ***.*: .
Mflv_1104|M.gilvum_PYR-GCK FERISRHPDVLARLQAEADT---DGNEYRQAVILETQRVRTVIDFAGR--
Mvan_5712|M.vanbaalenii_PYR-1 FERISRHPEVLAKLVAEAET---DGNEYRQATILEIQRSRTVIDFAGR--
MSMEG_6478|M.smegmatis_MC2_155 FERISRHPGVLEKLVAEAAT---DDNEYRQAAIAEVQRVRTVIDFSGR--
TH_0082|M.thermoresistible__bu FERITRHPEVLARLAAEADT---DENTYRQATILEVQRARTVIDFSGR--
MAB_1427c|M.abscessus_ATCC_199 FERITRHPEVLSRLAEEAQG---DSNEYRQATILEVQRSRPVIDFAGR--
Mb0141|M.bovis_AF2122/97 FERLSRHPDVLAALVEEVDN---GGHELRQAAILEVQRARTVIDFAAR--
Rv0136|M.tuberculosis_H37Rv FERLSRHPDVLAALVEEVDN---GGHELRQAAILEVQRARTVIDFAAR--
MAV_5160|M.avium_104 FERISRHPELLARLVEEADN---GGNELRQAAILEVQRARTVIDFAGR--
MMAR_3976|M.marinum_M FERLGRHPDVLAALVEEADR---GGRALRQATILEVQRTRPAIDRVVR--
MUL_0473|M.ulcerans_Agy99 LIELLRHPDAYAAVIDELDELYADGQLVSFHALRQIPRLENVLKETLRLH
MLBr_02088|M.leprae_Br4923 VLAMLRNPSQWKALSSNPQR--------APLVVEETLRYDPAIHLIGR--
. : *:* : : .: : * .:. *
Mflv_1104|M.gilvum_PYR-GCK -------HVYAPTFELGEWIIPQGYSIVVAIGQVHHREQDYLDPEDFDPQ
Mvan_5712|M.vanbaalenii_PYR-1 -------HVYAPTFELGEWVIPQGYSIVVAIGQVHKRAQDFDDPDRFDPQ
MSMEG_6478|M.smegmatis_MC2_155 -------HVYAPSFQLGQWTIPRGYSIMVAIAHIQEREEEFSDPHRFDPQ
TH_0082|M.thermoresistible__bu -------HVYAPTLELGDWVIPRGYSIVVSISQLHERSAEFPRPDEFDPD
MAB_1427c|M.abscessus_ATCC_199 -------HVLAPHVDIGPYRIPQGHSVVVSINLMHDDPVAFPCPERFDPE
Mb0141|M.bovis_AF2122/97 -------RVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQ
Rv0136|M.tuberculosis_H37Rv -------RVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQ
MAV_5160|M.avium_104 -------HVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFDPQ
MMAR_3976|M.marinum_M -------RVCSPYYRLGQWVLPQGYSVHLHIEQVQSDPEIFPDPERFDPH
MUL_0473|M.ulcerans_Agy99 PPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPDEFVPE
MLBr_02088|M.leprae_Br4923 --------VAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPD
* : : .* : : : * * *.
Mflv_1104|M.gilvum_PYR-GCK RFVGQRPS----TLSHIPFGGGTRRCVGAVFANVEMDIVLRTVFRHFTIE
Mvan_5712|M.vanbaalenii_PYR-1 RYIGQRPP----TFAHIPFGGGTRRCVGAAFANVEMDIVLRTVLRHFVIE
MSMEG_6478|M.smegmatis_MC2_155 RFVGNRP-----GLGWLPYGGGTRRCVGAVFANIEMDVVLRTILRHFVIE
TH_0082|M.thermoresistible__bu RFVGSRPP----MFAWLPYGGGTRRCVGAVFANVEMDVVLRTVLRHFTLE
MAB_1427c|M.abscessus_ATCC_199 RFMGAKP-----GNSWVPYGGGTRRCVGAAFANMEMDIVLRTVLRHFTIE
Mb0141|M.bovis_AF2122/97 RYIGSKPS----PFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTLE
Rv0136|M.tuberculosis_H37Rv RYIGSKPS----PFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTLE
MAV_5160|M.avium_104 RFIDNKPS----ALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFTIE
MMAR_3976|M.marinum_M RHMGGKPS----SLGWIPFGGGTRRCIGAALANLEIDVVLRTVLRNFTIE
MUL_0473|M.ulcerans_Agy99 RYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFE
MLBr_02088|M.leprae_Br4923 RP----------SSRHLAFAVGSHFCLGAALARLEATVTLSAISARFPQV
* :.:. * : *:**.:* :: : .: .:
Mflv_1104|M.gilvum_PYR-GCK TTTAPGEKMHSRG-VAYTPDDGGRVVMRRR--------
Mvan_5712|M.vanbaalenii_PYR-1 TTAAPGEKMHSRG-VAYTPKDGGRVVMRRR--------
MSMEG_6478|M.smegmatis_MC2_155 TTTAPDEKVHPRG-VAYTPASGGRVVMRRRREPLGA--
TH_0082|M.thermoresistible__bu TTTAPDEKVHSRG-VAYTPKDGGRVTLHRR--------
MAB_1427c|M.abscessus_ATCC_199 TTTAPDEKWHSRG-VASCPKNNGRVTVRRR--------
Mb0141|M.bovis_AF2122/97 TTTAAGERSHGRG-VAFTPKDGGRVVMRRR--------
Rv0136|M.tuberculosis_H37Rv TTTAAGERSHGRG-VAFTPKDGGRVVMRRR--------
MAV_5160|M.avium_104 TTDAPDEPWHCRG-VAFTPKHGGRIVVHRR--------
MMAR_3976|M.marinum_M PNAAPDERWHNRG-IAFTPKDGGQIVVHRRH-------
MUL_0473|M.ulcerans_Agy99 MAQPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH
MLBr_02088|M.leprae_Br4923 QLAG--ELVYKPN-VAMRGMSALPVQV-----------
. . :. :