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AEATTDPIQLPPGPNASKLTQTLVYVFAKARARTRLTNRYGSGYSLNLPKYGPTLVISDPAMLKELFTSG NDLVTRPTTLGKLLGPGSILSMIGVEHRQRRKLMVPPFSGRRIDAYVKIVEEEFLREAQTWPEETEFESL QALVNITGSIVLRTILGAHGAIFEELQYLGPRTIVLAARMIALPEWLRRDLGPWSPWGKIQAARSRFDEL IAQLIAEARADPNFETRTDMLAMMLQARYDDGSPITDAHISDEMLTMIVAGHETTATTLAWAVERLRRSP SFVAQLVDEIDNGGTALMQATVWEVQRTRPVLDFIARRVETQLRLGPWVLPKGHMIVGDVWAAQHASSSF KDPERFDPTRFADGPPESYAWIPFGGGIHRCIGAAFANMEMTTVLRTLLRKFELVPTDAPAEPIRSRGIT NAPGHGGRIVVRSRPAGARAAYASEDGHSAVAQSV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4430 | cyp138B1 | - | 100% (456) | cytochrome P450 138B1 Cyp138B1 |
| M. marinum M | MMAR_3976 | cyp138A4 | e-103 | 46.56% (436) | cytochrome P450 138A4 Cyp138A4 |
| M. marinum M | MMAR_0346 | cyp138A3 | e-103 | 44.52% (438) | cytochrome P450 138A3 Cyp138A3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0141 | cyp138 | 1e-107 | 45.22% (429) | cytochrome P450 138 |
| M. gilvum PYR-GCK | Mflv_3376 | - | 1e-127 | 51.03% (437) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0136 | cyp138 | 1e-107 | 45.22% (429) | cytochrome P450 138 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-12 | 26.90% (197) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1427c | - | 1e-103 | 42.96% (426) | putative cytochrome P450 |
| M. avium 104 | MAV_5160 | - | 1e-111 | 45.68% (440) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_6478 | - | 1e-97 | 40.59% (441) | putative cytochrome P450 135B1 |
| M. thermoresistible (build 8) | TH_0082 | - | 1e-104 | 42.92% (445) | putative cytochrome P450 135B1 |
| M. ulcerans Agy99 | MUL_0473 | cyp51B1 | 3e-24 | 24.53% (371) | cytochrome P450 51B1 Cyp51B1 |
| M. vanbaalenii PYR-1 | Mvan_3108 | - | 1e-126 | 49.10% (444) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3376|M.gilvum_PYR-GCK ---------MATATTDPVR--LPPGPRFPKLIQGGAVLAFRYG-------
Mvan_3108|M.vanbaalenii_PYR-1 ---------MATATTDPVR--LPPGPRIPKLIQGAAVLTQRYG-------
MMAR_4430|M.marinum_M ---------MAEATTDPIQ--LPPGPNASKLTQTLVYVFAKAR-------
MSMEG_6478|M.smegmatis_MC2_155 MT-ATVERP--ESAIRAAQ--LPPVLPLPKTVQGLAFSVARRW-------
TH_0082|M.thermoresistible__bu MT-EATIAPDVDHAVRSQK--LPPAVPLPKSLQGIAFIASRRW-------
MAB_1427c|M.abscessus_ATCC_199 MEGDVTEISTIDRAADVPKPIAPPLVTLPKLAQGIAFVASRRW-------
Mb0141|M.bovis_AF2122/97 ----MSEVVTAAPAPPVVR--LPPAVRGPKLFQGLAFVVSRRR-------
Rv0136|M.tuberculosis_H37Rv ----MSEVVTAAPAPPVVR--LPPAVRGPKLFQGLAFVVSRRR-------
MAV_5160|M.avium_104 ----MSEVATAPLA--AVH--LPPAVRGPKLLQGIGFAVSRRT-------
MUL_0473|M.ulcerans_Agy99 ---------MTTAIVPRVS------GGEEEHGHLEEFRTDPIG-------
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
. .
Mflv_3376|M.gilvum_PYR-GCK -SVAALGRRYGSTFTLQLPVFGETVVISDPVLVKDLFSTSRELVGRPQNN
Mvan_3108|M.vanbaalenii_PYR-1 -AIAALGRRYGPTFTLNIPVFGETVVISDPVLVKDLFSTHRDLVGRPQNN
MMAR_4430|M.marinum_M -ARTRLTNRYGSGYSLNLPKYGPTLVISDPAMLKELFTSGNDLVTRP-TT
MSMEG_6478|M.smegmatis_MC2_155 -VVKQAARRYGDVVTLDIPVFGRTVLVTEPQLAKQVYAAHPDDVGNVQPN
TH_0082|M.thermoresistible__bu -TLTTATRRYGDVFRLNIPVFGRTVVVSDPVLAKQVFSANPDDVGNIQPN
MAB_1427c|M.abscessus_ATCC_199 -TTSRLAKKYGKVYTINIPKFGYTVVVADPDLTREVFTTSTEILGNIQPN
Mb0141|M.bovis_AF2122/97 -LLGRFVRRYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPN
Rv0136|M.tuberculosis_H37Rv -LLGRFVRRYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPN
MAV_5160|M.avium_104 -MMRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQIFTTSPDELGNIQPN
MUL_0473|M.ulcerans_Agy99 -LMQRVRDECGDVGWFQLANK-HVVLLSGAKANEFFFRSSDEELDQAEAY
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
* : . . :
Mflv_3376|M.gilvum_PYR-GCK LGG-----DVLGPGSIFNLEGDELLARRKLLLPPFNGKNMRAYEDITEQE
Mvan_3108|M.vanbaalenii_PYR-1 LGG-----DVLGPGSIFNLEGDALQARRKLLLPPFNGKSMRGYASITEEE
MMAR_4430|M.marinum_M LG------KLLGPGSILSMIGVEHRQRRKLMVPPFSGRRIDAYVKIVEEE
MSMEG_6478|M.smegmatis_MC2_155 LS------RMLGPGSVFALDGTDHRRRRKLLTPPFHGRSIKNYERIFEEE
TH_0082|M.thermoresistible__bu LS------RVLGPGSVFALDGAEHRRRRKLLTPPFHGKSIKNYEKIFEEE
MAB_1427c|M.abscessus_ATCC_199 LS------QQLGPGSVFALERNEHRHRRKLLAPKFHGKAMVQYEQIIEEE
Mb0141|M.bovis_AF2122/97 LS------RMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEE
Rv0136|M.tuberculosis_H37Rv LS------RMFGSGSVFALDGDDHRRRRRLLAPPFHGKSMKNYETIIEEE
MAV_5160|M.avium_104 LS------RLFGSGSVFGLEGDDHRRRRRLLAPPFHGKSMKNYESIIEEE
MUL_0473|M.ulcerans_Agy99 PFMT----PIFGKGVVFDASPE--RRKEMLHNSALRGEHMKGHATTIERE
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
: . .: . * : . :
Mflv_3376|M.gilvum_PYR-GCK VIREMQSWPEGVEFETLEPMMRITLNTILRAVFGAKGD-ELDELRVVIPA
Mvan_3108|M.vanbaalenii_PYR-1 AIREIRTWPEGVEFETLEPMMRITLNTILRAVFGAEGE-QLDELRELMPK
MMAR_4430|M.marinum_M FLREAQTWPEETEFESLQALVNITGSIVLRTILGAHGA-IFEELQYLGPR
MSMEG_6478|M.smegmatis_MC2_155 TLREAASWPDGQEFRTLEPMMRITLNVILRAVFGADGE-QLDELRRIIPP
TH_0082|M.thermoresistible__bu TLAEAANWPEGREFPTLEPMMRITLNAILRAVFGAEGE-HLDELRRIIPP
MAB_1427c|M.abscessus_ATCC_199 TLRECATWPEGQQFETMEPMMRITLNAILRAVFGADGA-ELDVLRRLIPP
Mb0141|M.bovis_AF2122/97 TLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGS-ELDELRRLIPP
Rv0136|M.tuberculosis_H37Rv TLRETANWPQGQAFATLPSMMHITLNAILRAIFGAGGS-ELDELRRLIPP
MAV_5160|M.avium_104 TLRETAGWPEGESFPTLPPMMRITLNAILRAVFGAEGA-ELDELRRLIPP
MUL_0473|M.ulcerans_Agy99 VHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFRNQLDSRFAHFCH
MLBr_02088|M.leprae_Br4923 VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYE-DAPEFGRVSAL
: : : ::*.
Mflv_3376|M.gilvum_PYR-GCK AVEFGSKIALLPSVVRKDLGAWSPGGKFARYRRRMDEICTQLIADARSDP
Mvan_3108|M.vanbaalenii_PYR-1 AVEFGSKIALMPSIVRKDFGPWSPGGKFARYRKRMDELLNGLLNDARSDP
MMAR_4430|M.marinum_M TIVLAARMIALPEWLRRDLGPWSPWGKIQAARSRFDELIAQLIAEARADP
MSMEG_6478|M.smegmatis_MC2_155 WVTLGSRLAVLPT-PKRNYGRLTPWGRLAAYRAEYDDVVDRLIDRVEADP
TH_0082|M.thermoresistible__bu WVTLGSRVATLPT-PSRNYGRFSPWGRLAAYRRCYDEVIGRLIDKVQADP
MAB_1427c|M.abscessus_ATCC_199 WVVLASLTTRIPQ-PKRNYGRFSPWGRLKTYRAHYDAVIGSLIEKALAAP
Mb0141|M.bovis_AF2122/97 WVTLGSRLAALPK-PKRDYGRLSPWGRLAEWRRQYDTVIDKLIEAERADP
Rv0136|M.tuberculosis_H37Rv WVTLGSRLAALPK-PKRDYGRLSPWGRLAEWRRQYDTVIDKLIEAERADP
MAV_5160|M.avium_104 WVTLGSRLAALPK-PQR-YPRFGPWGQLDRWRRQYDGVIERLIAAEQADP
MUL_0473|M.ulcerans_Agy99 ELERGTDPLCYVD----PYLPIESFRRRDEARKGLVALVQDIMHQRVANP
MLBr_02088|M.leprae_Br4923 LVQSVDPFITITG------EPPEATEERLRAGVWLRDYLEQLVKCRRGTP
: . . :: . *
Mflv_3376|M.gilvum_PYR-GCK DFTDRG-DVLSLLLQARYDNGDP-IPDAFVVDELLTMLVAGHETTSTQLA
Mvan_3108|M.vanbaalenii_PYR-1 NFTERN-DVLSLLLQARYDDGSP-MPDSFILDELLTMLVAGHETTSTQLA
MMAR_4430|M.marinum_M NFETRT-DMLAMMLQARYDDGSP-ITDAHISDEMLTMIVAGHETTATTLA
MSMEG_6478|M.smegmatis_MC2_155 DFDQRD-DILALLLRSAYEDGSS-MSRKDIGDELLTLLAAGHETTASTLG
TH_0082|M.thermoresistible__bu HFEERD-DVLALLLRSTYEDGTA-MTRQDIADELLTLLAAGHETTASTMG
MAB_1427c|M.abscessus_ATCC_199 DFEDRT-DILALLLRSTYDDGTT-MSRSDVSDELLTLLAAGHETTATTLA
Mb0141|M.bovis_AF2122/97 NFADRT-DVLALMLRSTYDDGSI-MSRKDIGDELLTLLAAGHETTAATLG
Rv0136|M.tuberculosis_H37Rv NFADRT-DVLALMLRSTYDDGSI-MSRKDIGDELLTLLAAGHETTAATLG
MAV_5160|M.avium_104 NFAERT-DVLALLLRSTYDDGAA-MSHKEIGDELLTLLAAGHETTASTLA
MUL_0473|M.ulcerans_Agy99 PTDKRDRDMLDVLVSITDEQGNPRFCTDEVTGMFISLMFAGHHTSSGTSA
MLBr_02088|M.leprae_Br4923 GE-----DLISRLIELD-ESGDQ-LTEEEIIATCGLLLVAGHETTVNLIA
*:: :: :.* : : :: ***.*: .
Mflv_3376|M.gilvum_PYR-GCK WTIERIRRHPDLLARLSDEVDA---GGNELMAATIAESQRTRPVLTAALR
Mvan_3108|M.vanbaalenii_PYR-1 WTIERIRRHPQLLVRLTEEVDA---GGNELLLATIAESQRTRPVLTAALR
MMAR_4430|M.marinum_M WAVERLRRSPSFVAQLVDEIDN---GGTALMQATVWEVQRTRPVLDFIAR
MSMEG_6478|M.smegmatis_MC2_155 WAFERISRHPGVLEKLVAEAAT---DDNEYRQAAIAEVQRVRTVIDFSGR
TH_0082|M.thermoresistible__bu WVFERITRHPEVLARLAAEADT---DENTYRQATILEVQRARTVIDFSGR
MAB_1427c|M.abscessus_ATCC_199 WAFERITRHPEVLSRLAEEAQG---DSNEYRQATILEVQRSRPVIDFAGR
Mb0141|M.bovis_AF2122/97 WAFERLSRHPDVLAALVEEVDN---GGHELRQAAILEVQRARTVIDFAAR
Rv0136|M.tuberculosis_H37Rv WAFERLSRHPDVLAALVEEVDN---GGHELRQAAILEVQRARTVIDFAAR
MAV_5160|M.avium_104 WAFERISRHPELLARLVEEADN---GGNELRQAAILEVQRARTVIDFAGR
MUL_0473|M.ulcerans_Agy99 WTLIELLRHPDAYAAVIDELDELYADGQLVSFHALRQIPRLENVLKETLR
MLBr_02088|M.leprae_Br4923 NAVLAMLRNPSQWKALSSNPQR--------APLVVEETLRYDPAIHLIGR
.. : * * : : .: : * .: *
Mflv_3376|M.gilvum_PYR-GCK ---------RART-RIRLGEWVIPEGDTIMASTQLAMAAEQSFPDAEKFN
Mvan_3108|M.vanbaalenii_PYR-1 ---------RART-RIRLGEWVIPEGDTILASTQLAMAAESSFPDADKFN
MMAR_4430|M.marinum_M ---------RVET-QLRLGPWVLPKGHMIVGDVWAAQHASSSFKDPERFD
MSMEG_6478|M.smegmatis_MC2_155 ---------HVYAPSFQLGQWTIPRGYSIMVAIAHIQEREEEFSDPHRFD
TH_0082|M.thermoresistible__bu ---------HVYAPTLELGDWVIPRGYSIVVSISQLHERSAEFPRPDEFD
MAB_1427c|M.abscessus_ATCC_199 ---------HVLAPHVDIGPYRIPQGHSVVVSINLMHDDPVAFPCPERFD
Mb0141|M.bovis_AF2122/97 ---------RVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQPDRFD
Rv0136|M.tuberculosis_H37Rv ---------RVNPPVYQLGEWVIPRGYSIIINIAQIHGDPDVFPQPDRFD
MAV_5160|M.avium_104 ---------HVYPDVYRLGEWVIPRGYSIIVGIAQIHDNPDVFPDPRRFD
MUL_0473|M.ulcerans_Agy99 LHPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPDEFV
MLBr_02088|M.leprae_Br4923 ----------VAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFD
. : : .* : : . .*
Mflv_3376|M.gilvum_PYR-GCK PDRFVGNPPN----PFAWIPFGGGMMRCIGASFATMEMDVTLRTMLREFR
Mvan_3108|M.vanbaalenii_PYR-1 PDRFVGNPPN----PFAWIPFGGGMMRCIGASFATMEMEVTLRALLREFT
MMAR_4430|M.marinum_M PTRFADGPPE----SYAWIPFGGGIHRCIGAAFANMEMTTVLRTLLRKFE
MSMEG_6478|M.smegmatis_MC2_155 PQRFVGNRP-----GLGWLPYGGGTRRCVGAVFANIEMDVVLRTILRHFV
TH_0082|M.thermoresistible__bu PDRFVGSRPP----MFAWLPYGGGTRRCVGAVFANVEMDVVLRTVLRHFT
MAB_1427c|M.abscessus_ATCC_199 PERFMGAKP-----GNSWVPYGGGTRRCVGAAFANMEMDIVLRTVLRHFT
Mb0141|M.bovis_AF2122/97 PQRYIGSKPS----PFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFT
Rv0136|M.tuberculosis_H37Rv PQRYIGSKPS----PFAWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFT
MAV_5160|M.avium_104 PQRFIDNKPS----ALSWIPFGGGTRRCVGAAFANMEMDVVLRTVLRHFT
MUL_0473|M.ulcerans_Agy99 PERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYE
MLBr_02088|M.leprae_Br4923 PDRP----------SSRHLAFAVGSHFCLGAALARLEATVTLSAISARFP
* * :.:. * *:** :* :: : .: .:
Mflv_3376|M.gilvum_PYR-GCK LEPTDEPDEKPHSR-GVTVTPGRGGRAVVRRRRTPASGDANS----VSVA
Mvan_3108|M.vanbaalenii_PYR-1 IEPTTEPDEKPHSR-GVTVTPGRNGRLVVHRREHKAARATDS----VSVA
MMAR_4430|M.marinum_M LVPTDAPAEPIRSR-GITNAPGHGGRIVVRSRPAGARAAYASEDGHSAVA
MSMEG_6478|M.smegmatis_MC2_155 IETTTAPDEKVHPR-GVAYTPASGGRVVMRRRREPLGA------------
TH_0082|M.thermoresistible__bu LETTTAPDEKVHSR-GVAYTPKDGGRVTLHRR------------------
MAB_1427c|M.abscessus_ATCC_199 IETTTAPDEKWHSR-GVASCPKNNGRVTVRRR------------------
Mb0141|M.bovis_AF2122/97 LETTTAAGERSHGR-GVAFTPKDGGRVVMRRR------------------
Rv0136|M.tuberculosis_H37Rv LETTTAAGERSHGR-GVAFTPKDGGRVVMRRR------------------
MAV_5160|M.avium_104 IETTDAPDEPWHCR-GVAFTPKHGGRIVVHRR------------------
MUL_0473|M.ulcerans_Agy99 FEMAQPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH----------
MLBr_02088|M.leprae_Br4923 QVQLAG--ELVYKP-NVAMRGMSALPVQV---------------------
. :.
Mflv_3376|M.gilvum_PYR-GCK ETSR
Mvan_3108|M.vanbaalenii_PYR-1 ESS-
MMAR_4430|M.marinum_M QSV-
MSMEG_6478|M.smegmatis_MC2_155 ----
TH_0082|M.thermoresistible__bu ----
MAB_1427c|M.abscessus_ATCC_199 ----
Mb0141|M.bovis_AF2122/97 ----
Rv0136|M.tuberculosis_H37Rv ----
MAV_5160|M.avium_104 ----
MUL_0473|M.ulcerans_Agy99 ----
MLBr_02088|M.leprae_Br4923 ----