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MAYVIADLEAMAAAAADLAGVNSAIAAANGIAAVPTTAVQACAGDQVSAAVAALFAAHAQGYQSISAQMS AMHDQLVQTLSASSASYAGAEASNAAQAFLDLINAPTQALLGRPLIGNGADGATVGGIGTPGGAGGLLYG NGGRGGDSTLAGVSGGGGGDAGLIGNGGAGGTGGNGGSGGLGGNAWLLGSGGTGGTGGAGVSSGFGGTGG NGGLGGLLYGSGGAGGTGGAGAAGAVLGGMGGLGGDARLFGTGGAGGTGGDNSLGLTGQGGQGGDGGYGG ALFGSGGSGGGGGAGSSAGGDGGAGGASGYGIGNGGAGGAAGDGGGAGSLGTGGNGGSGGRAALLYGVGG DGGAGGAGGDVVGSAGGSGGFGGAAGLVGVGGDGGAGGAGGGAGGDGGAGAYLIGDGGDGGAGGDGNAGS LAGGTGGNGGDAKLIGNGGNGGDGGVGFGGGANGSGGTGGAAGLLGSPGSDGTTV
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3729 | - | - | 100% (475) | PE-PGRS family protein, PE_PGRS25 |
M. marinum M | MMAR_3728 | - | e-145 | 55.85% (487) | PE-PGRS family protein, PE_PGRS2 |
M. marinum M | MMAR_4223 | - | e-137 | 48.20% (610) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0545 | PE_PGRS6a | 1e-139 | 51.03% (584) | hypothetical protein Mb0545 |
M. gilvum PYR-GCK | Mflv_5091 | - | 2e-87 | 43.35% (496) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv3388 | PE_PGRS52 | 1e-138 | 51.28% (548) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 6e-13 | 38.04% (92) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 5e-46 | 36.84% (361) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 1e-23 | 43.79% (169) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-71 | 43.85% (431) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 2e-40 | 40.13% (304) | PUTATIVE - |
M. ulcerans Agy99 | MUL_3672 | - | 0.0 | 84.16% (486) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 6e-89 | 44.63% (475) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_3729|M.marinum_M -------------------------------------------------- MUL_3672|M.ulcerans_Agy99 -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Rv3388|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------------MMFLAPPG MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_3729|M.marinum_M -------------------------------------------------- MUL_3672|M.ulcerans_Agy99 -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Rv3388|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ---------------------------------------MVTFGGGATPT Mvan_1264|M.vanbaalenii_PYR-1 GPGPISAAIQLTSTGSEATEP----------------WYVVSFGGSGAPT MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_3729|M.marinum_M -------------------------------------------------- MUL_3672|M.ulcerans_Agy99 -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Rv3388|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK PTSLGAA------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 PNNLAAS------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_3729|M.marinum_M -------------------------------------------------- MUL_3672|M.ulcerans_Agy99 -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Rv3388|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_3729|M.marinum_M -------------------------------------------------- MUL_3672|M.ulcerans_Agy99 -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -------------------------------------------------- Rv3388|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK --------------------AVDLSGTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 --------------------LVDLSGTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_3729|M.marinum_M -------------------------MAYVIADLEAMAAAAADLAGVNSAI MUL_3672|M.ulcerans_Agy99 -------------------------MAYVIADLEAMAAAAADLAGVNSAI Mb0545|M.bovis_AF2122/97 -------------------------MSNLLVTPELVAAAAADLAGIGSAI Rv3388|M.tuberculosis_H37Rv -------------------------MSFVIANPEMLAAAATDLAGIRSAI Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MAB_4284c|M.abscessus_ATCC_199 ---MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAVSAAQVGAVMPV MLBr_01183|M.leprae_Br4923 ------------------------MPLFLNAEPQALTAAANTLEGLSAAT MAV_4827|M.avium_104 -------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAA MMAR_3729|M.marinum_M AAANGIAAVPTTAVQACAGDQVSAAVAALFAAHAQGYQSISAQMSAMHDQ MUL_3672|M.ulcerans_Agy99 AAANGIAAVPTTAVQACAGDQVSAAVAALFAAHAQGYQSISTQMSAMHDQ Mb0545|M.bovis_AF2122/97 GAANAAAGAPTMALLAAGADEVSAAVAAVFSSYAQQYQALSAAAAAFHDQ Rv3388|M.tuberculosis_H37Rv SAATAAAAAPTIQVAAAGADEVSLAISALFGQHAQAYQALSAQATIFHDQ Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG TH_3810|M.thermoresistible__bu GDGGSGGRTGLFSKLSRGGDGGDGGLG-------------GNGGHGGGTG MAB_4284c|M.abscessus_ATCC_199 VAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGPSILSPSLLSP MLBr_01183|M.leprae_Br4923 VASNAAAAQLTTEIAPPAADDVSILLAHFFSGHGRQYQAHASQGATNHQD MAV_4827|M.avium_104 TASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARR . . . MMAR_3729|M.marinum_M LVQTLSASSASYAGAEASNAAQAFLDLINAPTQALLG------------- MUL_3672|M.ulcerans_Agy99 LVQTLSASSASYAGAEASNAAQASLDLINAPTQALLG------------- Mb0545|M.bovis_AF2122/97 FVRALAAGAGAYAGAEAANVEQQLLNAINAPTLALLG------------- Rv3388|M.tuberculosis_H37Rv FVQALTSGGNLYAAAESHTVEQMVLNAINAPTQTLFG------------- Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT TH_3810|M.thermoresistible__bu IIS--------------------LLSLAGNGGNGG--------------- MAB_4284c|M.abscessus_ATCC_199 RDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNR------------- MLBr_01183|M.leprae_Br4923 LIQSLLTSSSAYAG------------TETANHDSL--------------- MAV_4827|M.avium_104 IDNVMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDT------------ MMAR_3729|M.marinum_M ----------------------RPLIGNGADGAT---------------- MUL_3672|M.ulcerans_Agy99 ----------------------RPLIGNGADGAT---------------- Mb0545|M.bovis_AF2122/97 ----------------------RPLIGNGADGA----------------- Rv3388|M.tuberculosis_H37Rv ----------------------RPLIGDGANGT----------------- Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG------ Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG------ MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------GPLLDLSFGDLQFG-------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---------------------ATLAVVETSDGS----------------- MMAR_3729|M.marinum_M ------VGGIGTPGGAGGLLYGNGGRG-------GDSTLAGVSGGGGGDA MUL_3672|M.ulcerans_Agy99 ------VGRIGTPGGAGGLLYGNGGRG-------GDSTLAGVSGGGGGYA Mb0545|M.bovis_AF2122/97 -------AGTGQAGGAGGLLYGNGGNG-------GSG-AAGQAGGAGGAA Rv3388|M.tuberculosis_H37Rv -------AEN-PDGQNGGLLFGNGGNG-------FTQTTAGVAGGNGGSA Mflv_5091|M.gilvum_PYR-GCK -AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGLG Mvan_1264|M.vanbaalenii_PYR-1 -VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTAG MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS TH_3810|M.thermoresistible__bu --------NGYRTTDNNALDGGHGGNG-----------------GNVGFF MAB_4284c|M.abscessus_ATCC_199 -------NRDTTAIGDGAVAVGGSNSG-----PIASGQGSTAVNGDVRDS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------IPDVYKQQIRAESYGDAAGQ-------LSAMVAGLEKLESLPG MMAR_3729|M.marinum_M GLIGNGGAGGTG--------------------GNGGSGGLGGN-AWLLGS MUL_3672|M.ulcerans_Agy99 GLIGNGGAGGTG--------------------GNGGSGGLGGN-AWLLGS Mb0545|M.bovis_AF2122/97 GLIGHGGTGGVG--------------------GTGAAGGAGGTGGWLFGN Rv3388|M.tuberculosis_H37Rv GLIGNGGAGGGG--------------------GAGAAGGLGGNGGWLYGN Mflv_5091|M.gilvum_PYR-GCK ETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGAG Mvan_1264|M.vanbaalenii_PYR-1 ETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGVG MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY TH_3810|M.thermoresistible__bu SLFNLGGAGGWG--------------------GSGVDG------------ MAB_4284c|M.abscessus_ATCC_199 NIINADHGSNVG--------------------VDQSQTRVGGDYTNVSGH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GLLLVGSGVDVAP------------------LKQVLQTTTFLDVSVAEEP MMAR_3729|M.marinum_M ------------GGTGG-------TGGAGVS------------------- MUL_3672|M.ulcerans_Agy99 ------------GGTGG-------TGGAGVS------------------- Mb0545|M.bovis_AF2122/97 ------------GGAGG-------TGGAVT-------------------- Rv3388|M.tuberculosis_H37Rv ------------GGAGG-------IGGAGT-------------------- Mflv_5091|M.gilvum_PYR-GCK ----------STGAVGG-------VGGKG----IQGGQG----------- Mvan_1264|M.vanbaalenii_PYR-1 ----------ATGGAGG-------VGGKG----IQGGQG----------- MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA TH_3810|M.thermoresistible__bu -----------VDVVGG--------------------------------- MAB_4284c|M.abscessus_ATCC_199 G----------SADIDKSVTVVDDHSQRNTTN----------------IN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 E----------TALARG--------------------------------- MMAR_3729|M.marinum_M ----SGFGGTGGNGGLGG--LLYGS----------------------GGA MUL_3672|M.ulcerans_Agy99 ----SGFGGTGGNGGLGG--LLYGS----------------------GGA Mb0545|M.bovis_AF2122/97 -----GVSTTGGPGGHGGDAGLYGF----------------------GGA Rv3388|M.tuberculosis_H37Rv -----GTGGHGGAGGAGGRAWLWGT----------------------GGA Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV TH_3810|M.thermoresistible__bu -------NPDGGTPG------------------------------AHGES MAB_4284c|M.abscessus_ATCC_199 DSFNTDRSTNIGSGNTTNTEIGSHN------------------QANIGTS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ---AALAAANAPLFASSTAALAYAQ---------------------DPGT MMAR_3729|M.marinum_M GGTGG--------AGAAG-------------------------------- MUL_3672|M.ulcerans_Agy99 GGTGG--------AGAAG-------------------------------- Mb0545|M.bovis_AF2122/97 GGAGG-----FGQSGAAG-------------------------------- Rv3388|M.tuberculosis_H37Rv GGAGGDGGWLFGDGGAGGTGGNGGSGFNSLTSSVGGAGGAGGHAGLFGAG Mflv_5091|M.gilvum_PYR-GCK GGNGG-------NGGRGGLFG---------------KGGNAGNGAD---- Mvan_1264|M.vanbaalenii_PYR-1 GGNGG-------NGGRGSLFG---------------RGGNAGNGGN---- MSMEG_0868|M.smegmatis_MC2_155 GGNGG-------FTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQ TH_3810|M.thermoresistible__bu HTPGV-------YTDRQ--------------------------------- MAB_4284c|M.abscessus_ATCC_199 TSAGG-------SAAVGGNAG----------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GAVDQYSLPDYLYVPVDPEPG----------------------------- MMAR_3729|M.marinum_M ------------------AVLGGMGGLGG-DARLFGTGGAGG-------- MUL_3672|M.ulcerans_Agy99 ------------------AVLGGMGGLGG-DARLFGTGGAGG-------- Mb0545|M.bovis_AF2122/97 ----------------------GAGGAGGAGGWLYGDGGDGG-------- Rv3388|M.tuberculosis_H37Rv GTGGTGGIGGQNTETGPAASNGGAGGAGGGGGYLVGDGGAGG-------- Mflv_5091|M.gilvum_PYR-GCK ------------------GGTGGAGGAGGTGG-TGGAGGTGG-------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------GGTGGNGGNGGTGG-TGGNGGTGG-------- MSMEG_0868|M.smegmatis_MC2_155 AYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKAN TH_3810|M.thermoresistible__bu ----------------------GEDGEDGTGTGIGGRGGNGG-------- MAB_4284c|M.abscessus_ATCC_199 --------------------LAGNAGLAGNAGLAGNAGLAGN-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------DDELAYSAVGEEDAESPTVVIEKLFLPED-------- MMAR_3729|M.marinum_M ---------TG---GDNSLG----LTGQGGQGGDGGYGGALFGSGGSGGG MUL_3672|M.ulcerans_Agy99 ---------TG---GDNSLG----LTGQGGQGGD---------------- Mb0545|M.bovis_AF2122/97 ---------AGGNGG-NESG--TGVSGVGGVGGAGGAGGLLFGNGGDGGV Rv3388|M.tuberculosis_H37Rv ---------TGGAGGKNSSGGATLTGGTGGTGGAGGAAGWLYGSGGAGGA Mflv_5091|M.gilvum_PYR-GCK ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGH TH_3810|M.thermoresistible__bu --------SSSGTHPMAEDG--------EHVKALDGRPGLD---GGNGSH MAB_4284c|M.abscessus_ATCC_199 -------AGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 --------SEPRRRPVLLVGSGLAVVGISAVLALEIALAIGIRTTGTVAL MMAR_3729|M.marinum_M GGAGS---------SAGGDGGAGGASGYGIGNGGAGGAAG---------- MUL_3672|M.ulcerans_Agy99 -------------------AGAGGASGYGIGNGGAGGAAG---------- Mb0545|M.bovis_AF2122/97 GGDGGDGSSTQDSGGDGGAGGAGGAGGWLLGNGGAGGAGG--AASIKVAT Rv3388|M.tuberculosis_H37Rv GGAGGLNNAGGATGGTGGTGGAGGSGAWLYGNGGAAGAGGNGGNNTSAGT Mflv_5091|M.gilvum_PYR-GCK GGTGG-------KGGTGGTGGAGGTG----GDGGTGGTGGTGGTG----- Mvan_1264|M.vanbaalenii_PYR-1 GGTGG-------KGGTGGTGGDGGTG----GTGGTGGTGGTGGTG----- MSMEG_0868|M.smegmatis_MC2_155 GGDGG-------RGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVD TH_3810|M.thermoresistible__bu GGNGG-------HGGRGGFLGIGGSG-------GWGGHGGNGGD------ MAB_4284c|M.abscessus_ATCC_199 GLAGN-------AGLAGNAGLAGNAG--LAGNAGLAGNAGLAGNAGLAGN MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 QPTPNQHLIVPTEQAPAPPPVQASAPQPKISVPEPVAAPKPLSPPVAAPL MMAR_3729|M.marinum_M --------DGGGAGSLG------------TGGNGGSGGR----------- MUL_3672|M.ulcerans_Agy99 --------DGGGAGSLG------------TGGNGGSGGR----------- Mb0545|M.bovis_AF2122/97 GGL---GGDGGDAGLFG------------FGGDGGWGGRGVDAR----FG Rv3388|M.tuberculosis_H37Rv GGVGASGGTGGNAGLIG------------AGGHGGAGGAGGNQTGGVGNG Mflv_5091|M.gilvum_PYR-GCK ----GTGGTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQG Mvan_1264|M.vanbaalenii_PYR-1 ----GTGGTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQG MSMEG_0868|M.smegmatis_MC2_155 PSHTGAGGNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKG TH_3810|M.thermoresistible__bu -----TDADGGNGGDG---------------GNGGSAG------------ MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAGLAG---------NAAVAGNAAVAGNAAVAGNAAVGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 PAAPPPAAPPLPEAPPIPAAPPVVPVPVVVPPVPVPVPVRIPVPDPVSPP MMAR_3729|M.marinum_M ----------------------------AALLYGVGGDG----------- MUL_3672|M.ulcerans_Agy99 ----------------------------AALLYGVGRDG----------- Mb0545|M.bovis_AF2122/97 AAGG-----------------AAGAGGAGGWLYGDGGAG----------- Rv3388|M.tuberculosis_H37Rv GAGG-----------------NGGAGGAGGQLYGNGGDG----------- Mflv_5091|M.gilvum_PYR-GCK GQGG-----------------TGGTGGQGG-LGGGGGTG----------- Mvan_1264|M.vanbaalenii_PYR-1 GQGG-----------------TGGTGGQGG-LGGVGGTG----------- MSMEG_0868|M.smegmatis_MC2_155 GDGGEALIRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVV TH_3810|M.thermoresistible__bu ---------------------RGGTGGLRGVFGINGGNG----------- MAB_4284c|M.abscessus_ATCC_199 VLNT------------------GVSGAIGGSSHVGGAIN----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 QLLAPPR--------------LSVPQPVQPPVRVPQPPS----------- MMAR_3729|M.marinum_M ---------------GAGGAGGD----VVGSAGGSG--------GFGGAA MUL_3672|M.ulcerans_Agy99 ---------------GAGGAGGD----GVGSAGGSG--------GLGGAA Mb0545|M.bovis_AF2122/97 ---------------GVGGVGGAVFSLSSG-DGGAG--------GAGGGG Rv3388|M.tuberculosis_H37Rv ---------------GNGGAGGANIAGGNGSDGGAA--------GHGGAG Mflv_5091|M.gilvum_PYR-GCK ------------GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAG Mvan_1264|M.vanbaalenii_PYR-1 ------------GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAG MSMEG_0868|M.smegmatis_MC2_155 QANPQASGTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNG TH_3810|M.thermoresistible__bu -------------RAGLGGRGXXXXGGGVGAAVRSG-------------- MAB_4284c|M.abscessus_ATCC_199 -----------ESLGGSGSVGGSTAVGGGAHTGVGG--------GVSTGV MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ----------------PPQVGGTVPQSPPQHQTPPGE-------GTPPKP MMAR_3729|M.marinum_M G---LVGVG---GDGGAG---------------------GAGG------G MUL_3672|M.ulcerans_Agy99 G---LVDVG---GDGGAG---------------------GAGG------G Mb0545|M.bovis_AF2122/97 G--WLFGNG---GDGGAG--------------------GGGGGRFGSGSG Rv3388|M.tuberculosis_H37Rv GSARLIGAGGHGGDGGAGGNTAGRRADAIAGTGGDGGNGGNGGLLSGNAG Mflv_5091|M.gilvum_PYR-GCK GDGGLGGLG---GFGGSGG------------------TGGQGGLGGPGGS Mvan_1264|M.vanbaalenii_PYR-1 GDGGLGGLG---GFGGVGG------------------TGGQGGQGGPGGS MSMEG_0868|M.smegmatis_MC2_155 GDGIDGGLG---GNGGDGV------------------VNTTANAANPGSA TH_3810|M.thermoresistible__bu -NGVFSGGG---GTPSAGF------------------GVPTTIQFPAGSC MAB_4284c|M.abscessus_ATCC_199 GVGSHVGGGISESLGGSGS-------------------VGGSTAVGGGAH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 DGPGNYGGGHVPTPGAGGS-------------------GGSGGGHVPTPG MMAR_3729|M.marinum_M AGGDGGAGAY------------------------------LIGDGGDGGA MUL_3672|M.ulcerans_Agy99 AGGDGGAGAY------------------------------LIGDGGDGGA Mb0545|M.bovis_AF2122/97 AGGDGAVGG-------------------------AGGAGAWFGNGGAGGV Rv3388|M.tuberculosis_H37Rv AGGHGGAGGSSTATTTTGTPPTGATG-GNGGNGGAGGTAGFTGSGGIGGN Mflv_5091|M.gilvum_PYR-GCK TGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQ Mvan_1264|M.vanbaalenii_PYR-1 TGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVTGASGASGGKGAQ MSMEG_0868|M.smegmatis_MC2_155 TGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGE TH_3810|M.thermoresistible__bu TSRAVSREG------------------------IMPSSRAASARAG---- MAB_4284c|M.abscessus_ATCC_199 TGVGGGVSTG----------------VGVGSHVGGGISESLGGSGSVGGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 AGGSGGSGGG---------------------------HVPTPGTGGPGGT MMAR_3729|M.marinum_M G------------------------------GDGNAGSLAG--------- MUL_3672|M.ulcerans_Agy99 GGHGGDG---------------------GAGGDGNAGSLAG--------- Mb0545|M.bovis_AF2122/97 GGGGGRG-------------------TTAIGGDGGAGGAGGAG------- Rv3388|M.tuberculosis_H37Rv GGAGGTGGNA--------GVALSVGSTGGLGGNGGSGGLGGGG------- Mflv_5091|M.gilvum_PYR-GCK GATGAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG--- Mvan_1264|M.vanbaalenii_PYR-1 GATGAQGATG------AQGATG-ATGASGAQGSAGSAGSAGVAGSAG--- MSMEG_0868|M.smegmatis_MC2_155 ASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFS TH_3810|M.thermoresistible__bu -----------------------AACASSTSRSRRSFCCSRA-------- MAB_4284c|M.abscessus_ATCC_199 TAVGGGAHTG---------------VGGGVNTGVGVGSHVGGG------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 GGSGGGHVPTP---------------GAGTPGGSGGGHLPFPG------- MMAR_3729|M.marinum_M -------------------------------------------------- MUL_3672|M.ulcerans_Agy99 -------------------------------------------------- Mb0545|M.bovis_AF2122/97 -----------------GWLYGDGGAGGAGGGGGRGG------------- Rv3388|M.tuberculosis_H37Rv -----------------GSLFGNGGAGGVGATGGNGGSGIG--------- Mflv_5091|M.gilvum_PYR-GCK --------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG----- Mvan_1264|M.vanbaalenii_PYR-1 --------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG----- MSMEG_0868|M.smegmatis_MC2_155 NIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIAN TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------ISESLGGSGSVGGSTAVGGG------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_3729|M.marinum_M ---------------------GTGGNGG--------------DAKLIGNG MUL_3672|M.ulcerans_Agy99 ---------------------GTGGNGG--------------DAKVIGNG Mb0545|M.bovis_AF2122/97 -------------TGNDGGDGGDGGRGG--------------DAQLLGNG Rv3388|M.tuberculosis_H37Rv ----------PASVGGNGGKGGVGAAGG--------------LAGQIGNG Mflv_5091|M.gilvum_PYR-GCK ---AAGEDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEGGDG Mvan_1264|M.vanbaalenii_PYR-1 ---AAGDAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEGGAG MSMEG_0868|M.smegmatis_MC2_155 SSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------AHTSAINDALGGSGSVGG---------------STAVGGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 ------------------AGSTPGGSGG-------------GHLPTPGAG MMAR_3729|M.marinum_M GNGG-----------DGGVG----FGG---GANGSGGTGGAAG---LLGS MUL_3672|M.ulcerans_Agy99 GNGG-----------DGGVR----FGG---GANGSGGTGGAAG---LLGS Mb0545|M.bovis_AF2122/97 GDGG-----------AGGAGGPAGFGAS-PGAGAAGGGGGAGG--SLFGS Rv3388|M.tuberculosis_H37Rv GSGG-----------SGGAGGNGGTGDT-AGNGGNGGAGAVGGNAQLIGN Mflv_5091|M.gilvum_PYR-GCK GKGGAGAE--------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGS Mvan_1264|M.vanbaalenii_PYR-1 GAGGDGSE--------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGA MSMEG_0868|M.smegmatis_MC2_155 GNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGT TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_4827|M.avium_104 TPGGGLGG------FGGGHAPAPGGGLGGGGGHAPAPGGGLGGFGGGHSG MMAR_3729|M.marinum_M PGSDGTTV--------- MUL_3672|M.ulcerans_Agy99 PGSDGTTV--------- Mb0545|M.bovis_AF2122/97 PGTTGPHG--------- Rv3388|M.tuberculosis_H37Rv GGNGGGGGNGGTGADGT Mflv_5091|M.gilvum_PYR-GCK GGSGGAAGDSDD----- Mvan_1264|M.vanbaalenii_PYR-1 GGSGGAAGDSD------ MSMEG_0868|M.smegmatis_MC2_155 PGTAGTTGANNP----- TH_3810|M.thermoresistible__bu ----------------- MAB_4284c|M.abscessus_ATCC_199 SETAHTTLPGAEHH--- MLBr_01183|M.leprae_Br4923 ----------------- MAV_4827|M.avium_104 GGLGGLGGGHK------