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MRCRPPSRNRSAHTARNTRPCSLKSRRFTVRFHQTLAAAANSYADAEAAIASTRQNQLAVPAAAPTPAAA AMIPPFPANLTTLFFGPTGIPLPPPSMLTPPIRCRSVRRALQAVFTPEELYPLTGVRSLVLNTSVEEGLT ILHDAIMVELATTGNAVTVFGWSQSAIIASLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPD LTLPTLDLTFYGATPSDTIYPTAIYTLEYDGFADFSRYPLNFISDLNAVAGITFVHTKYLDLTPAQVEGA TKLPTSPGYTGVTDYYIIRTENRPLLQPLRAVPVIGDPLADLIQPNLKVIVNLGYGDPNYGYSTSYADVR TPFGLWPNVPPQVIADALAAGTQEGILDFTADLQALSAQPLTLPQIQLPQPADLVAAVAAAPTPAEVVNT LARIISTNYAVLLPTVDIALALVTTLPLYTTQLFVRQLAAGNLINAIGYPLAATVGLGTIDSGRRGIAHP PRGGLGHRSKHRGPRHLTDSRRHRRPPTTVYRPRQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0157c | PE2 | - | 100% (525) | PE family protein |
| M. bovis AF2122 / 97 | Mb0156c | PE1 | e-126 | 54.08% (466) | PE family protein |
| M. bovis AF2122 / 97 | Mb1828 | PPE28 | e-101 | 45.51% (490) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1918 | - | 3e-32 | 34.27% (321) | hypothetical protein Mflv_1918 |
| M. tuberculosis H37Rv | Rv0152c | PE2 | 0.0 | 100.00% (525) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 1e-05 | 24.17% (240) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 2e-28 | 30.32% (310) | PE/PPE family protein |
| M. marinum M | MMAR_0370 | - | 1e-179 | 68.93% (457) | PE family protein |
| M. avium 104 | MAV_1760 | - | 4e-10 | 26.91% (275) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_5455 | - | 1e-29 | 31.20% (343) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 9e-38 | 41.42% (239) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 5e-97 | 45.36% (485) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_4726 | - | 8e-30 | 32.38% (244) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0157c|M.bovis_AF2122/97 -----MRCRPP-------------SRNRSAHTARNTRPCSLKSRR-----
Rv0152c|M.tuberculosis_H37Rv -----MRCRPP-------------SRNRSAHTARNTRPCSLKSRR-----
MMAR_0370|M.marinum_M --MSYLLAEPELLASVATEIDGIGSAISTAGTAAAGPTSSLLAAAGDEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
Mflv_1918|M.gilvum_PYR-GCK --MGKGD-----------------FGLKASEFTGRSSTRFADSVRR----
MSMEG_5455|M.smegmatis_MC2_155 --MGRLL-----------------HSLSTAFLVFVAVVVLCVSTS-----
MLBr_01232|M.leprae_Br4923 ---------------------------MKRLLATTLAALTVGTVS-----
MAV_1760|M.avium_104 ---------------------------MKQLLAGVTALLSVSTAG-----
TH_3724|M.thermoresistible__bu -------------------------VVAVGALTWGGXGVASPAGQP----
Mvan_4726|M.vanbaalenii_PYR-1 ----------------------MRRRLRSAAWGLLSLVIAVLFAWG----
MAB_4141|M.abscessus_ATCC_1997 -------------------------MAGQYSVPGKRHSLRRYVAT-----
Mb0157c|M.bovis_AF2122/97 -----------------------FTVRFHQTLAAAANSYADAEAAIASTR
Rv0152c|M.tuberculosis_H37Rv -----------------------FTVRFHQTLAAAANSYADAEAAIASTR
MMAR_0370|M.marinum_M GAIANLFSVYGRECQAVLAQVEAFRSEFAQTLAAAGVAYAQTEAASLAAL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
Mflv_1918|M.gilvum_PYR-GCK -------------------RPGGATYGLYRHDGLGVGTWAWVFARSSRSF
MSMEG_5455|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------GFGSTVASSEPGEPWLPPSPVPVR
MAV_1760|M.avium_104 --------------------------YFGIGTAAADGGPIGGPPTPGAPG
TH_3724|M.thermoresistible__bu --------------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0157c|M.bovis_AF2122/97 Q-------NQLAVPAAAP---TPAAAAMIP--PFPANLTTLFFGPTGIPL
Rv0152c|M.tuberculosis_H37Rv Q-------NQLAVPAAAP---TPAAAAMIP--PFPANLTTLFFGPTGIPL
MMAR_0370|M.marinum_M R-------GALGIPSAAP---AVSSASTIP--PFTANLTSLFLGPTGVPI
MUL_0967|M.ulcerans_Agy99 AGLTEPVANLFAPVLSGPESVAASATALLSGAPLKPVEAALILSESGVPT
Mflv_1918|M.gilvum_PYR-GCK PRSRRCWRYPRGVPTPVAVLVANTTALVMG--GTFHPLTGPRDSPEFVTA
MSMEG_5455|M.smegmatis_MC2_155 ------------MPTAAHLLLNHPHALVIG--GTGTPVP----PPEYVNG
MLBr_01232|M.leprae_Br4923 EN------------SPAKIVYALGGARPPT---FDWDYYTIRAGDEFFPD
MAV_1760|M.avium_104 D----------------QTAYALGGAHVLG---IPYDQYIRMEGADWFPG
TH_3724|M.thermoresistible__bu ------------ERAAALRLTATADAIIMP-----GTKIGYIPSQDEFTA
Mvan_4726|M.vanbaalenii_PYR-1 -------------SVVTSTSAGAGTALVMG--GNGHPLSVPQDTPDYINK
MAB_4141|M.abscessus_ATCC_1997 -------------ITAVAATCTVLAPLAMESRTIASTLASYVIGIGGNND
.
Mb0157c|M.bovis_AF2122/97 PPPSMLTPP--IRCR---SVRRALQAVFTPEELYPLTGVRSLVLNTSVEE
Rv0152c|M.tuberculosis_H37Rv PPPSMLTPP--IRCR---SVRRALQAVFTPEELYPLTGVRSLVLNTSVEE
MMAR_0370|M.marinum_M PDESYVQAANNLFVR---SSD-ILRPLYTPEELYPLTGVKSLTLNASVEE
MUL_0967|M.ulcerans_Agy99 PSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGIKDLSLDISLAR
Mflv_1918|M.gilvum_PYR-GCK YLDNAVDNQISAAYG---YAVTNAVAVYTPEEFFPLGG---LTFDDSVAE
MSMEG_5455|M.smegmatis_MC2_155 QTDNYIGAEFPGEYR---YAVH------TPQNFWPVYGS--MSFDESTVA
MLBr_01232|M.leprae_Br4923 VNRKLIDYPARAPFR--YVPTFLVPGP-----------RDEVTIGEAIAV
MAV_1760|M.avium_104 QQRQIVRYPAGQVQG--HVLERLFPGIGKLDESFPGLGMDGPSVGESVAE
TH_3724|M.thermoresistible__bu YATAVIGATAGAPGA--------VDYLGVPGEFWPATGLDSLTFDASVAX
Mvan_4726|M.vanbaalenii_PYR-1 YVTAADDAFIAPSGLCG--PQCSLVATYTPAQIRFVNGIFDMTYDESVAV
MAB_4141|M.abscessus_ATCC_1997 GASANIPRKLGGAYS------VDYHPVSYPGAIWPVSGLTAPTFKTSVAQ
:
Mb0157c|M.bovis_AF2122/97 GLTILHDAIMVELATT------------------GNAVTVFGWSQSAIIA
Rv0152c|M.tuberculosis_H37Rv GLTILHDAIMVELATT------------------GNAVTVFGWSQSAIIA
MMAR_0370|M.marinum_M GLTILDNAIMAQLSIP------------------GNSVTVFGYSQSAIIA
MUL_0967|M.ulcerans_Agy99 GATILNDAILQQLAALP----------------AGSSVAVLGYSQSAVLS
Mflv_1918|M.gilvum_PYR-GCK GLANLGRCLRAEPGCVFNADPAVAARVGTVAPRHDDTFVVFGYSQSAAVA
MSMEG_5455|M.smegmatis_MC2_155 GLAALQAEMAKEG-------------------HFGSPLVILGYSSSTRIL
MLBr_01232|M.leprae_Br4923 ATKNLNQAIHRGT----------------------EPAAVVGLSQGSLAL
MAV_1760|M.avium_104 GIDNLDAAIRTTG----------------------RPGTAIGLSEGAFVV
TH_3724|M.thermoresistible__bu GQAMLTPMVDGAIES-------------------DTPIVVFGHSQSAVIA
Mvan_4726|M.vanbaalenii_PYR-1 GQANLNDCIQGSDCTATLAPYSETG----PHTVADSTYVIYAYSQSATVA
MAB_4141|M.abscessus_ATCC_1997 GRTNLNDEIVTAG---------------------NQPITIVGYSLGAVVV
. * : . . . * .:
Mb0157c|M.bovis_AF2122/97 SLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDLT
Rv0152c|M.tuberculosis_H37Rv SLEMQRFTAMGGAAPSASDLNFVLVGNEMNPNGGMLARFPDLTLPTLDLT
MMAR_0370|M.marinum_M SLEMQKLAALGPSAPTASQLNFVLVGNEMNPNGGMLARFPDLSLPSLGLT
MUL_0967|M.ulcerans_Agy99 SRVMPKLLAEG---VTSSQVNFVLLGNPMNPNGGVLARFPDLTLPSLGFT
Mflv_1918|M.gilvum_PYR-GCK SLLKRQLIDAP--GPEPAATTFMLAANPMRPNGGVLGRFPALTIPILGIT
MSMEG_5455|M.smegmatis_MC2_155 TADKNRRIAD---GDYAVDINYVLVSDVAKGNGGVMARFPGWHIPILGVT
MLBr_01232|M.leprae_Br4923 DTEQEQLATDP-TAPPPDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIP
MAV_1760|M.avium_104 DGEQARLANDP-TAPPPNTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVP
TH_3724|M.thermoresistible__bu TKEKQRLLAEYPDPDTAPDVTFVMVANPNRPNGGLLARFPGLYIPILGVT
Mvan_4726|M.vanbaalenii_PYR-1 ANQKLQLIAHP----VASTVSFLLVANPNRPDGGILERFVGAYIPLLGIT
MAB_4141|M.abscessus_ATCC_1997 SKSHSDLLQRY--PGGNPNIQFVLMGSANTPNGGIFARFPWLKIPLADIE
: .. .. : .
Mb0157c|M.bovis_AF2122/97 FYGATPS----DTIYPTAIYTLEYDGFA-DFSRYPLNFISDLNAVAGITF
Rv0152c|M.tuberculosis_H37Rv FYGATPS----DTIYPTAIYTLEYDGFA-DFSRYPLNFISDLNAVAGITF
MMAR_0370|M.marinum_M FYGATPS----DTIYPTAIYTLEYDGFA-DFPRYPLNFIADLNAVMGIPF
MUL_0967|M.ulcerans_Agy99 FYGATP-----DNAFPTVSYTLEYDGFA-DFPRYPINLLADINAVMGIPF
Mflv_1918|M.gilvum_PYR-GCK FHGATPTAG-VDGAYRTVDVVRQYDGLGGDFPVRPLNLLATVNALLGYGI
MSMEG_5455|M.smegmatis_MC2_155 FDGATRTDS-DGYAFDTKSISFVHDGWS-DFPVYPLNVLALANAVAGIAV
MLBr_01232|M.leprae_Br4923 LIDYTMPQR-MDSQYDSNRVVAAYDGLS-EFPDRADNLLAQLNCFAGGAI
MAV_1760|M.avium_104 ALDYTMPPP-YESQYDTNRFVAAYDSIA-DFPDRPDNMFALANTLMGLAT
TH_3724|M.thermoresistible__bu FNGATPAP--ADGPFDSYDVAREFDGWA-DFPRYPLNLVATANAILGIYY
Mvan_4726|M.vanbaalenii_PYR-1 FNGSTPTFSPQPRPLTTVDVARQYDGWA-DFPTNPLNLLADLNAIMGTIL
MAB_4141|M.abscessus_ATCC_1997 SNGAWEP-----DQFKTKVINTEYDTYG-DFPAY-FNPLALANSIAAIQY
. : .* . :*. * .: * . .
Mb0157c|M.bovis_AF2122/97 VHT-KYLDLTPAQVEGA-TKLPTSPGYTGVTDYYIIRTENRPLLQPLRAV
Rv0152c|M.tuberculosis_H37Rv VHT-KYLDLTPAQVEGA-TKLPTSPGYTGVTDYYIIRTENRPLLQPLRAV
MMAR_0370|M.marinum_M VHV-KYLDLTAAQVDSA-IELPTSPGYSGVTSYYVIPTENLPLLEPLRAI
MUL_0967|M.ulcerans_Agy99 VHA-DYQDLTQAQLDSA-VQLPTEG--PTQSTYYMIPTEHLPLLAPLRFI
Mflv_1918|M.gilvum_PYR-GCK MHG-ETVDVPFAQARFQ-GRE-------GDTDYYLIGTDLLPLLQPLLLF
MSMEG_5455|M.smegmatis_MC2_155 LHP-TYPELDRPDLVPV-GST-------GDTEYFVIGTDIMPLLMPLETI
MLBr_01232|M.leprae_Br4923 SHT-PSGFFNPEDVPPQ-NIRTTVNSRGAKTTTYLIPVNHLPLTLPLRYL
MAV_1760|M.avium_104 GHT-AVAFTNPSMVPPQ-NIRTTINSRGAKDTTIMIPEKHLPLVMPLKYI
TH_3724|M.thermoresistible__bu LHG-GYYELLTENPDILDDPERTIVQQYGDTTYYLIRTEQLPLLRPLRDL
Mvan_4726|M.vanbaalenii_PYR-1 LHP-NYSDAGTPQLQGQ----------YQDSTYYLIPAPITPVLVPLTWV
MAB_4141|M.abscessus_ATCC_1997 AHPDAYYDRIDPAALDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDL
* :: *: ** .
Mb0157c|M.bovis_AF2122/97 P--VIGDPLADLIQPNLKVIVNLGYGDPNYGYSTSYADVRTPFGLWP-NV
Rv0152c|M.tuberculosis_H37Rv P--VIGDPLADLIQPNLKVIVNLGYGDPNYGYSTSYADVRTPFGLWP-NV
MMAR_0370|M.marinum_M P--VIGNPLANLIQPDLKVIVNLGYGDPNYGYSTSYADVRTPFGLFP-DV
MUL_0967|M.ulcerans_Agy99 P--YVGDPLAELLEPNLRVLVNFGYGDPAYGYDTGPANVPTPFGLFP-PV
Mflv_1918|M.gilvum_PYR-GCK ---VPRPILSALDAP-LRVLVEDAYDR------DAGPGDPTTARWWP-VK
MSMEG_5455|M.smegmatis_MC2_155 G--VPRPILLAVDEP-LRVLVEAGYRR------DIAPGAPTPARLIP-IV
MLBr_01232|M.leprae_Br4923 G--WSDALVDQIDAV-LQPKIDAAYAY-----NDNPLNKPISVDPVN-GM
MAV_1760|M.avium_104 G--IDENTLNKLDAI-LTPRVNAGYSR-----NDDPATAPVQVDPVH-GF
TH_3724|M.thermoresistible__bu G--VPEEFVDALEPY-VRRIVDLGYDR------NTPYGEPAPVRVLP-PL
Mvan_4726|M.vanbaalenii_PYR-1 P--IVGKPLAIALDPAVRVLVEMGYDR------TVNPGQPTPARYLY-VP
MAB_4141|M.abscessus_ATCC_1997 TNPIGASFVLDAIEPTLRVFIDMAYDR------DTGPGTTTQFSFFTPSK
: : :: .*
Mb0157c|M.bovis_AF2122/97 PPQVIADALAAGTQEGILDFTADLQ-----------ALSAQPLTLPQIQL
Rv0152c|M.tuberculosis_H37Rv PPQVIADALAAGTQEGILDFTADLQ-----------ALSAQPLTLPQIQL
MMAR_0370|M.marinum_M SPGTIVDALAAGTQEGIQDFTADLQ-----------AMFGQPIPTPDIVP
MUL_0967|M.ulcerans_Agy99 SPLTVAEHLAAGTQQGIVNSGAALQ-----------AQGPPSIPLSDIAH
Mflv_1918|M.gilvum_PYR-GCK DFAGTAAKLIASVPVAVDNLTEGFG-----------LGRVLGTPVPGVFG
MSMEG_5455|M.smegmatis_MC2_155 NPITLTRNFIAAIPVGVDDAMEELG-----------HGRPLGTQPSGVFG
MLBr_01232|M.leprae_Br4923 DP----IAGIDAELR---DSILNVF-----------AQLRSILPPPPG--
MAV_1760|M.avium_104 DPAEVTAPANQATFGGGADPLSQIM-----------AGAMSVLSHGAGEA
TH_3724|M.thermoresistible__bu TPAPGPATQHNAGQGITVASATSTP-----------DKRTPVVEAPVEEP
Mvan_4726|M.vanbaalenii_PYR-1 NLIKAALNFAMAIPTGWDDAISYLTGDP-------DCRPFHTTVPASPFG
MAB_4141|M.abscessus_ATCC_1997 NIVDAFNKLPTAIAEGAHNVENGLAGATPKQSASPEKPASPPVPQPGPTN
.
Mb0157c|M.bovis_AF2122/97 PQPADL-------------VAAVAAAPTPAEVVNTLARIISTNYAVLLPT
Rv0152c|M.tuberculosis_H37Rv PQPADL-------------VAAVAAAPTPAEVVNTLARIISTNYAVLLPT
MMAR_0370|M.marinum_M PTPADI-------------LGKLSELPSPAQVVNTLTAVVANDYAVLLPT
MUL_0967|M.ulcerans_Agy99 TLTAN---------------PPWAGTPALPPSTSPASSIEDFILAVQAAN
Mflv_1918|M.gilvum_PYR-GCK VGG-----------------PDLPDVDEGGAVTSDIDEDAVAQRDSASST
MSMEG_5455|M.smegmatis_MC2_155 VGGEDTELKGLPAGVISLAKPTLPVSSHTTVVEKTERKDLAKPAAEPEPV
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 DH------------------------------------------------
TH_3724|M.thermoresistible__bu PVQTGR---------------STLKREKPVSARHLVRNSLRAVPGLRRGE
Mvan_4726|M.vanbaalenii_PYR-1 VGGPPVYTGAIDPYGEPTPYLAPPVETHGEAAPGSGSPAAHPAGTEPPET
MAB_4141|M.abscessus_ATCC_1997 PGSATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGAST
Mb0157c|M.bovis_AF2122/97 VDIALALVTTLP-LYTTQLFVRQ----------LAAGN-LINAIGYPLAA
Rv0152c|M.tuberculosis_H37Rv VDIALALVTTLP-LYTTQLFVRQ----------LAAGN-LINAIGYPLAA
MMAR_0370|M.marinum_M ADIGLAVVTTLP-LYSTQLFFDQ----------LLQGN-LIDAFGYPIAA
MUL_0967|M.ulcerans_Agy99 SSISRGFVKTLSTAYATLLPTTD----------IASEL-VFTLPSYNLNL
Mflv_1918|M.gilvum_PYR-GCK ERSAPAEESRSAVGGADSDGRDD----------VVDPEPAAPEAETSEAE
MSMEG_5455|M.smegmatis_MC2_155 VEDEPAVEDETPVADTKKASPKP----------LRPKVRGPISFDAPKLP
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu PAATPTPDVTPDVTPDAPAGQPE----------PAEPNESAAPPAAAEAD
Mvan_4726|M.vanbaalenii_PYR-1 VTFSPTTESTPSTLLPETPAESE----------DMPPDFVENDTPDSDEV
MAB_4141|M.abscessus_ATCC_1997 ARDQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPG
Mb0157c|M.bovis_AF2122/97 TVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLTDSRRHRRPPTTVYRP
Rv0152c|M.tuberculosis_H37Rv TVGLGTIDSGRRGIAHPPRGGLGHRSKHRGPRHLTDSRRHRRPPTTVYRP
MMAR_0370|M.marinum_M TVGLLTIG-----------GAVEFLTIAAAAQTTVQDIGSLIP-------
MUL_0967|M.ulcerans_Agy99 FLDG--------------------VIQAINGQPIGD--------------
Mflv_1918|M.gilvum_PYR-GCK TVTETEADD---------ADDADDGADADDEDIDADGADADGEDTAGNTA
MSMEG_5455|M.smegmatis_MC2_155 TIRKATGDRPLKRLLSALTPKRPKPASSHDAGPAAGNKDTDNADKPAARA
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
TH_3724|M.thermoresistible__bu DASE----------------------------------------------
Mvan_4726|M.vanbaalenii_PYR-1 SPTEDDALKDTETINESQDGPTESASGVSGEDAADADSRSADADSLSADA
MAB_4141|M.abscessus_ATCC_1997 TAPKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHSQPANAPAHTSDKTS
Mb0157c|M.bovis_AF2122/97 RQ-------------
Rv0152c|M.tuberculosis_H37Rv RQ-------------
MMAR_0370|M.marinum_M ---------------
MUL_0967|M.ulcerans_Agy99 ---------------
Mflv_1918|M.gilvum_PYR-GCK EAA------------
MSMEG_5455|M.smegmatis_MC2_155 DDAA-----------
MLBr_01232|M.leprae_Br4923 ---------------
MAV_1760|M.avium_104 ---------------
TH_3724|M.thermoresistible__bu ---------------
Mvan_4726|M.vanbaalenii_PYR-1 GDSAPADAAAADTAA
MAB_4141|M.abscessus_ATCC_1997 DHASETGRGAA----