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VTDMTQRAFVTGANGFVGRSLSLRLRTLGWQVSGVDLVADPAHNIQGGDINTAGPWMTEAAAADAIFHTA AVVSNIADSDTAWRVNVLGTKKVIDATAPGAVFVHLSSVRAFSDLDFPDMVTEEHPVRTDGNAYVDTKVA SEQVVLQAHGAGRIDARIARPGDIYGPGSRPWTILPVEMIRSRQFVLPAMGRGVFSPIYIDDLVEGVVAL GSGGAASGQVFTISGGVGVTCAQFFGHYHRMLDRRGPLVLPTAAAVGLATVKARVLALSGKATEANAISV RYLARTGSYSIAKAQRILGFEPRFSLDAGMRATEIWLRDQGYLD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4385 | - | - | 100% (324) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0718c | - | 1e-14 | 25.16% (306) | NAD-dependent epimerase/dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 1e-13 | 26.11% (337) | UDP-glucose 4-epimerase GalE1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1136c | - | 2e-14 | 26.79% (321) | cholesterol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2075 | - | 5e-17 | 27.74% (328) | 3-beta hydroxysteroid dehydrogenase/isomerase |
| M. tuberculosis H37Rv | Rv1106c | - | 2e-14 | 26.79% (321) | cholesterol dehydrogenase |
| M. leprae Br4923 | MLBr_01942 | - | 2e-16 | 27.54% (334) | putative cholesterol dehydrogenase |
| M. marinum M | MMAR_3319 | - | 2e-68 | 45.43% (317) | dehydrogenase |
| M. avium 104 | MAV_1225 | - | 3e-17 | 28.53% (333) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_5228 | - | 5e-16 | 26.89% (331) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
| M. thermoresistible (build 8) | TH_3827 | - | 9e-93 | 51.57% (318) | PUTATIVE putative dehydrogenase |
| M. ulcerans Agy99 | MUL_0172 | - | 2e-17 | 26.75% (329) | cholesterol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4635 | - | 5e-16 | 27.11% (332) | 3-beta hydroxysteroid dehydrogenase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1136c|M.bovis_AF2122/97 -MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPS
Rv1106c|M.tuberculosis_H37Rv -MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPS
MAV_1225|M.avium_104 -MIGPMGDPSLTAELGRVLVTGGSGFVGANLVTTLLERGYQVRSFDRAPS
MUL_0172|M.ulcerans_Agy99 -MLRPMGDASLTTELGRVLVTGGSGFVGSNLVTTLLDRGHHVRSFDRAPS
Mflv_2075|M.gilvum_PYR-GCK ---------MLRTELGRVLVTGGSGFVGANLVTELLDRGLHVRSFDRVAS
Mvan_4635|M.vanbaalenii_PYR-1 ----MGDATTPTTELGRVLVTGGSGFVGANLVTELLDRGLQVRSFDRVPS
MSMEG_5228|M.smegmatis_MC2_155 -------MADSTTDLGRILVTGGSGFVGANLVTELLDRGYAVRSFDRVPS
MLBr_01942|M.leprae_Br4923 -MLRGVGNASLTTELGRVLVTGGSGFVGANLVTALLERGYQVRSFDRAPM
MAB_4385|M.abscessus_ATCC_1997 MTD---------MTQR-AFVTGANGFVGRSLSLRLRTLGWQVSGVD----
TH_3827|M.thermoresistible__bu MTDEDRI-PCGAMSRPSVFITGANGFIGRSLGAHFAENGYDVRGVD----
MMAR_3319|M.marinum_M MSEHEFDRPAPSLSGRTIFITGANGFIGRAMAARFRALGAVVRGVD----
::**. **:* : : * * ..*
Mb1136c|M.bovis_AF2122/97 LLPAHPQLEVLQGDITDADVCAAAVDG----IDTIFHTAAIIELMGGASV
Rv1106c|M.tuberculosis_H37Rv LLPAHPQLEVLQGDITDADVCAAAVDG----IDTIFHTAAIIELMGGASV
MAV_1225|M.avium_104 PLPAHPHLEVLQGDITDAGVCAAAVEG----IDTIFHTAAIIDLMGGASV
MUL_0172|M.ulcerans_Agy99 PLPPHPQLEVLQGDITDAATCATAVDG----VDTVFHTAAIIELMGGASV
Mflv_2075|M.gilvum_PYR-GCK ALPAHARLEIVEGDITDADDVAAAVEG----VDTVFHTAAIIDLMGGASV
Mvan_4635|M.vanbaalenii_PYR-1 PLPDHPGLEVVQGDITDVDDVARAVGTGADKADTVFHTAAIIDLMGGASV
MSMEG_5228|M.smegmatis_MC2_155 PLPAHAGLEVATGDICDLDNVTNAVAG----VDTVFHTAAIIDLMGGASV
MLBr_01942|M.leprae_Br4923 PLPQHPQLEVLQGDITDATVCTTAMDS----IDTVFHTAAIIELMGGASV
MAB_4385|M.abscessus_ATCC_1997 -LVADPAHNIQGGDINTAGPWMT---EAAA-ADAIFHTAAVVSNIADS--
TH_3827|M.thermoresistible__bu -LAADPARNVVAGDVVNPRPWKS---HLQG-CAVVLHTAAVVSNAVAA--
MMAR_3319|M.marinum_M -LAADPAGDVVAGDITRPETWAAGPTGLEG-ADTVIHTAALLGAAFPL--
* .. :: **: .::****::
Mb1136c|M.bovis_AF2122/97 TDEYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGD
Rv1106c|M.tuberculosis_H37Rv TDEYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGD
MAV_1225|M.avium_104 TEEYRQRSFAVNVGGTENLVRAGQAAGVQRFVYTSSNSVVMGGQNIVGGD
MUL_0172|M.ulcerans_Agy99 TDEYRKRSFSVNVGGTENLVRAGQQAGVKRFVYTSSNSVVMGGQIIAGGD
Mflv_2075|M.gilvum_PYR-GCK SEEYRQRSFAVNVTGTQNLVHAAQKAGVTRFVYTASNSVVMGGQRIAGGD
Mvan_4635|M.vanbaalenii_PYR-1 TEEYRQRSFAVNVTGTKNLVHAAQKAGVQRFVYTASNSVVMGGQRIAGGD
MSMEG_5228|M.smegmatis_MC2_155 TAEYRQRSFAVNVGGTENLVRAAQSAGVKRFVYTASNSVVMGGQHIVHGD
MLBr_01942|M.leprae_Br4923 TDEYRQRSYTVNVGGTENLLRAGQKSGVKRFVYTASNSVVMGGTPITGGD
MAB_4385|M.abscessus_ATCC_1997 -----DTAWRVNVLGTKKVIDATAPG--AVFVHLSSVRAFSDLDFPDMVT
TH_3827|M.thermoresistible__bu -----GQQWQANVLGTRRVLEAAARAGVERVVHFSSVRAYGDLGFPDGVK
MMAR_3319|M.marinum_M -----KQAWHVNVLGTSRVLRAAIDAGVRRFVHFSSVAAYG-FEFPDGAD
: .** ** .:: * . .*: :* .
Mb1136c|M.bovis_AF2122/97 ETLPYTDRFNDLYTETKVVAERFVLAQNGVDG---MLTCAIRPSGIWGNG
Rv1106c|M.tuberculosis_H37Rv ETLPYTDRFNDLYTETKVVAERFVLAQNGVDG---MLTCAIRPSGIWGNG
MAV_1225|M.avium_104 ETLPYTDRFNDLYTETKVLAERFVLGQNGVDG---MLTCAIRPSGIWGRG
MUL_0172|M.ulcerans_Agy99 ETLPYTNRFNDLYTETKVVAEKFVLSQNGNNE---MLTCAIRPSGIWGTG
Mflv_2075|M.gilvum_PYR-GCK ETLPYTERFNDLYTETKVVAEKFVLSQNGVSG---LLTCSIRPSGIWGRG
Mvan_4635|M.vanbaalenii_PYR-1 ETLPYTERFNDLYTETKVVAEKFVLSQNGVSG---MLTCSIRPSGIWGRG
MSMEG_5228|M.smegmatis_MC2_155 ETLPYTERFNDLYTETKVVAEKFVLGRNGVAG---MLTCSIRPSGIWGRG
MLBr_01942|M.leprae_Br4923 ETMPYTKRFNDLYTETKVVAEKFVLSQNGVPDGETMLTCSIRPSGIWGRG
MAB_4385|M.abscessus_ATCC_1997 EEHPVRTDG-NAYVDTKVASEQVVLQAHGAGR---IDARIARPGDIYGPG
TH_3827|M.thermoresistible__bu ETWPLRADG-RAYVDTKVAAEATAFAAHASGE---IAVTVVRPGDVYGPG
MMAR_3319|M.marinum_M ETYPVHVNG-DVYTDTKVNSEAVVLAAHGAGE---IDVTVIRPGDVWGPG
* * *.:*** :* .: :. : . **..::* *
Mb1136c|M.bovis_AF2122/97 DQTMFRKLFESVLKGHVKVLVGRKSARLDNSYVHNLIHGFILAAAHLVPD
Rv1106c|M.tuberculosis_H37Rv DQTMFRKLFESVLKGHVKVLVGRKSARLDNSYVHNLIHGFILAAAHLVPD
MAV_1225|M.avium_104 DQTMFRKLFESVIAGHVKVLIGRKSARLDNSYVHNLIHGFILAAQHLTPG
MUL_0172|M.ulcerans_Agy99 DQLMFRKLFESVIKGHVKVLVGPKSVLLDNSYVDNLIHGFMLAAQHLVPG
Mflv_2075|M.gilvum_PYR-GCK DQTMFRKVFESVLAGHVKVLVGNKETKLDNSYVHNLVHGFILAAEHLVEG
Mvan_4635|M.vanbaalenii_PYR-1 DQTMFRKVFESVLAGHVKVLVGNKNVKLDNSYVHNLVHGFILAAQHLVDG
MSMEG_5228|M.smegmatis_MC2_155 DQTMFRKVFESVLAGHVKVLVGRKSTLLDNSYVHNLVHGFILAAEHLTPN
MLBr_01942|M.leprae_Br4923 DQTMFRKAFESVVSGHVKVLIGSKNAKLDNSYVHNLVHGLILAAEHLVPG
MAB_4385|M.abscessus_ATCC_1997 SRPWTILPVEMIRSRQ-FVLPAMGRGVFSPIYIDDLVEGVVALGS----G
TH_3827|M.thermoresistible__bu SRPWTIIPVEEIKKGR-LILPAGGQGVFSPVYIDDLIAGILLAAT----H
MMAR_3319|M.marinum_M S-VWVRSPIAEMRKRTGFPLPNGGNGIFSPVYIDNFVDGMVLAVS----S
. . : * :. *:.::: *.:
Mb1136c|M.bovis_AF2122/97 GTAPGQAYFINDAEPINMFEFARPVLEACGQRWPKMRISGPAVRWVMTGW
Rv1106c|M.tuberculosis_H37Rv GTAPGQAYFINDAEPINMFEFARPVLEACGQRWPKMRISGPAVRWVMTGW
MAV_1225|M.avium_104 GTAPGQAYFINDAEPINMFEFARPVVEACGVNWPRVRVNGPIVRAAMTGW
MUL_0172|M.ulcerans_Agy99 GSAPGQAYFINDAEPINMFDFARPVVEACGEKWPRVRVSGPMVHRAMTGW
Mflv_2075|M.gilvum_PYR-GCK GSAPGQAYFINDGEPINMFEFARPVVQACGEPFPKFRVPGRLVWFAMTIW
Mvan_4635|M.vanbaalenii_PYR-1 GTAPGQAYFINDGEPINMFEFARPVMEACGEPWPTFRVSGRLVWFAMTIW
MSMEG_5228|M.smegmatis_MC2_155 GTAPGQAYFINDGEPVNMFEFARPVIEACGRKLPRVRVPGRAVHAAMSGW
MLBr_01942|M.leprae_Br4923 GTAPGQAYFINDGEPINFFDFMGPIIKACGENWPRVRISGRLVRNVMAVW
MAB_4385|M.abscessus_ATCC_1997 GAASGQVFTISGGVGVTCAQFFGHYHRMLDRRGPLVLPTAAAVGLATVKA
TH_3827|M.thermoresistible__bu PDAAGQDFNLPGVEPVTCKTFFGHYTRMLNKPPPRTVPTRVAIALATAAG
MMAR_3319|M.marinum_M DDAVGQIFNITDGKGVRCADFFGRMASMSDG-TIHTLPIRVAAPAAELLG
* ** : : . : * . .
Mb1136c|M.bovis_AF2122/97 QRLHFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPLFTTQQALT
Rv1106c|M.tuberculosis_H37Rv QRLHFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPLFTTQQALT
MAV_1225|M.avium_104 QRLHFRFGIPAPLLEPLAVERLYLDNFFSIAKASRDLGYQPLFTTEQAMS
MUL_0172|M.ulcerans_Agy99 QRLHFRFGLPAPLLEPLAVERLYLDNYFSVDKARRDLGYEPKFTTEQALK
Mflv_2075|M.gilvum_PYR-GCK QFLHFKFGLPKPLLEPLAVERLYLDNYFSIAKAQRDLGYQPLFTTEQALA
Mvan_4635|M.vanbaalenii_PYR-1 QFLHFRFGLPKPLLEPLAVERLYLDNYFSIAKAERDLGYRPLYTTEQALE
MSMEG_5228|M.smegmatis_MC2_155 QRLHFRFGIPEPLLEPLAVERLYLNNYFSIAKATRDLGYRPLFTTEQARV
MLBr_01942|M.leprae_Br4923 QRLHFGFGLPKPPMEPLAVERVYLDNYFSIEKAHKELGYRPLFTTEQAMA
MAB_4385|M.abscessus_ATCC_1997 RVLALSG--KATEANAISVRYLARTGSYSIAKAQRILGFEPRFSLDAGMR
TH_3827|M.thermoresistible__bu TVERFRG--RSSELNAETVYYLTRAGGYSRAKAERVLGWVPQVSLDEGMA
MMAR_3319|M.marinum_M SLLRRLG--QKTDLSAGTMWLLNRPGTYSIEKAQKMLGYQPRVSIEEGMA
. .. :: : . :* ** : **: * : : .
Mb1136c|M.bovis_AF2122/97 ECLPYYVSLFEQMKNEARAEKTAATVKP----
Rv1106c|M.tuberculosis_H37Rv ECLPYYVSLFEQMKNEARAEKTAATVKP----
MAV_1225|M.avium_104 ECLPYYVGMFEQMKRQALAGKASA--------
MUL_0172|M.ulcerans_Agy99 ECLPYYVDLFRQMKSEVKAGGR----------
Mflv_2075|M.gilvum_PYR-GCK QCIPYYVELFDRMKREAGNPVVQAAAPAPPKG
Mvan_4635|M.vanbaalenii_PYR-1 HCIPYYVDLFGRMKAEAAQPAVQAAAPVPPAG
MSMEG_5228|M.smegmatis_MC2_155 DCLPYYVDLFKQMEAQAR-PA-----------
MLBr_01942|M.leprae_Br4923 ECLPYYTELFEQIKVAAKPHLASIAATPRPE-
MAB_4385|M.abscessus_ATCC_1997 ATEIWLRDQGYLD-------------------
TH_3827|M.thermoresistible__bu RTEAWLRTEGYLD-------------------
MMAR_3319|M.marinum_M RVHEWARAERLI--------------------
: