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IGMTSQEIAFAPAQSQHTDHSARLLIWQTLVQTQRILTRWSRDFVTLIEALVFPILFMLVLKIVLGNLIY AVTHHDAMYSIVPLIALGAAITGSAFVAIDLMRERTSGLLSRLWVLPVHRMSGLMARILADAVRILFTTL VMLGVGILMGFEFRQGLIASLMWLCVPVTLGIAFAVMVTTVALYSSQAVIVEGVELTQAIAIFFSTGLIP LDQYPHWIQPVVAHQPVSYAVSAMRGLSMGGPVLLPMIGVLLWTAGICAVCAVPLAVGWRRASTH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2012 | drrC | - | 100% (276) | daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC |
| M. ulcerans Agy99 | MUL_2013 | drrB | 1e-11 | 27.41% (197) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. ulcerans Agy99 | MUL_4924 | - | 2e-07 | 21.05% (228) | hypothetical protein MUL_4924 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2963 | drrC | 1e-115 | 72.46% (276) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. gilvum PYR-GCK | Mflv_3387 | - | 4e-75 | 51.37% (255) | multidrug ABC transporter inner membrane protein |
| M. tuberculosis H37Rv | Rv2938 | drrC | 1e-115 | 72.46% (276) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. leprae Br4923 | MLBr_02350 | - | 1e-109 | 68.48% (276) | putative antibiotic resistance membrane protein |
| M. abscessus ATCC 19977 | MAB_1690 | - | 8e-08 | 22.57% (226) | ABC transporter transmembrane protein |
| M. marinum M | MMAR_1769 | drrC | 1e-153 | 100.00% (273) | daunorubicin-DIM-transport integral membrane protein ABC |
| M. avium 104 | MAV_2004 | - | 1e-48 | 38.55% (249) | ABC-2 type transporter |
| M. smegmatis MC2 155 | MSMEG_6510 | - | 2e-12 | 25.76% (229) | ABC-type drug export system, membrane protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3120 | - | 2e-74 | 50.59% (255) | multidrug ABC transporter inner membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 MSALVALTLRTMSGSRRDADLLFAALAPVGCFLGFTLVLGGLIRTGSMSY
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 PQYVLPVVIVQAMLFGAMTTADRAARDRLSGFGSRLRTLPLPASVPLGAR
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 MLYCLTRALIALAATMAAGWSFGFRMQGGPADAVLFVTIVVVFAMAVCLG
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 ADALGSRVGTVESSSQLLLLPQLVLVLLSTGIAPAESFPAWMAPFIRNQP
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3120|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2012|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1769|M.marinum_M --------------------------------------------------
Mb2963|M.bovis_AF2122/97 --------------------------------------------------
Rv2938|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02350|M.leprae_Br4923 --------------------------------------------------
MAV_2004|M.avium_104 VSQVTEALRGLATGHVAGGSLAAALTWCLGLLAVFGVVAVRMQRRVDAGR
MSMEG_6510|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1690|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_3387|M.gilvum_PYR-GCK -------------MTVESSP---PASYRVSGKHRRAHVWENSPRQLVPQV
Mvan_3120|M.vanbaalenii_PYR-1 -------------MTLESPESLVSAPYRPGGRHRREKVWENSPKRLVPQV
MUL_2012|M.ulcerans_Agy99 -------------MIGMTSQEIAFAPAQSQHTD-------HSARLLIWQT
MMAR_1769|M.marinum_M ----------------MTSQEIAFAPAQSQHTD-------HSARLLIWQT
Mb2963|M.bovis_AF2122/97 -------------MITTTSQEIELAPTRLPGSQ-------NAARLFVAQT
Rv2938|M.tuberculosis_H37Rv -------------MITTTSQEIELAPTRLPGSQ-------NAARLFVAQT
MLBr_02350|M.leprae_Br4923 -------------MITMISQTVGLVPASLQYPN-------NSVRALVSQT
MAV_2004|M.avium_104 SRAHRAVRKAPRDAAPAGDVGVNPVGKSAECLARQEVTRVGCLKGFVGQS
MSMEG_6510|M.smegmatis_MC2_155 -----------------MSVELVRAPRG-----------LRRVRAVAMRM
MAB_1690|M.abscessus_ATCC_1997 ------------------------------------------MTALSNTA
.
Mflv_3387|M.gilvum_PYR-GCK AVLTGRILRRWSRDPATLVQSMVMPAVFLIALDIVLGDVIEAVTG--HSG
Mvan_3120|M.vanbaalenii_PYR-1 AVLTGRILRRWSRDPATLVQSLVMPAVFLVALDIVLGDVIEQVTG--HSG
MUL_2012|M.ulcerans_Agy99 LVQTQRILTRWSRDFVTLIEALVFPILFMLVLKIVLGNLIYAVTH--HDA
MMAR_1769|M.marinum_M LVQTQRILTRWSRDFVTLIEALVFPILFMLVLKIVLGNLIYAVTH--HDA
Mb2963|M.bovis_AF2122/97 LLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTH--DSG
Rv2938|M.tuberculosis_H37Rv LLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLAYVVTH--DSG
MLBr_02350|M.leprae_Br4923 LLQTKRLLTRWARDYVTIIGALVLPILFLVVLNIVLGNLAYVVTY--DSG
MAV_2004|M.avium_104 ASEAGRLLRRWRRDPVVAVQALLFPTLLLVIYKLLVGKSVLAVTG--HDS
MSMEG_6510|M.smegmatis_MC2_155 GAFALVELQKLRHDRTELFTRMVQPALWLLIFGQTFSRLHVVDTGG-VPY
MAB_1690|M.abscessus_ATCC_1997 RLFRRYVVVGLRQPVFGFIFPIVFPVVLVIFVRSMFQRVADLPGFPLSSY
: : . :: * : :: .
Mflv_3387|M.gilvum_PYR-GCK LYGQVPLVALVGGMTGSIIGAVGIMRERDAGLLSRLWVVPVHRAAGLLAR
Mvan_3120|M.vanbaalenii_PYR-1 LYGQVPLVALVGGMTGAIIGAVGIMREREAGLLSRFWVVPVHRAAGLLAR
MUL_2012|M.ulcerans_Agy99 MYSIVPLIALGAAITGSAFVAIDLMRERTSGLLSRLWVLPVHRMSGLMAR
MMAR_1769|M.marinum_M MYSIVPLIALGAAITGSAFVAIDLMRERTSGLLSRLWVLPVHRMSGLMAR
Mb2963|M.bovis_AF2122/97 LYSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISR
Rv2938|M.tuberculosis_H37Rv LYSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISR
MLBr_02350|M.leprae_Br4923 LYSFVPLITLGAAITGSTFVAIDLVRERSIGLLSRLWVLPIHRASGLLAR
MAV_2004|M.avium_104 LYGLVPMCAVVGAVFGTIGAGLALPSERESGVLTRLWVQPVHRASPVAGR
MSMEG_6510|M.smegmatis_MC2_155 LAFLAPGIIAQSALFISIFYGIQIIWDRDAGILAKLMVTPAPASALVAGK
MAB_1690|M.abscessus_ATCC_1997 TAYIAPGLIMLIPMLGAGYGAGTLIDEIRSGFTDRLRLYGVSTGQIMAAK
.* : : . : : *. :: : : .:
Mflv_3387|M.gilvum_PYR-GCK LAADFIRITAITLVVMSVGLVLGFRFEQGIPAAIAWVFMPALFGVTLSAA
Mvan_3120|M.vanbaalenii_PYR-1 LAADFVRIVVITLVVMVVGLALGFRFEQGILAAVVWVFMPALFGVALSAA
MUL_2012|M.ulcerans_Agy99 ILADAVRILFTTLVMLGVGILMGFEFRQGLIASLMWLCVPVTLGIAFAVM
MMAR_1769|M.marinum_M ILADAVRILFTTLVMLGVGILMGFEFRQGLIASLMWLCVPVTLGIAFAVM
Mb2963|M.bovis_AF2122/97 ILANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAM
Rv2938|M.tuberculosis_H37Rv ILANAIRTLVTTLVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAM
MLBr_02350|M.leprae_Br4923 ILANTIRTFVTTLVMLVTGVILGFRFRQGVIASLMWVSVPVIFGIAIAVM
MAV_2004|M.avium_104 LVAEAARTVASAFVLTVFGIALGLRFNDGWIAMLAFVLVPVTISAGMATL
MSMEG_6510|M.smegmatis_MC2_155 AFAAGVRSVVQVIGVVALAYLMGIALTLNPLRILAAMGVVVLGAAFFACL
MAB_1690|M.abscessus_ATCC_1997 IGFEMFRILPAAVIVIGLLAFLDAPLRSGLLTGVFLVLVMFLWSAAYSSL
* .. : :. : . : : : . :
Mflv_3387|M.gilvum_PYR-GCK VLTLALLSSSTIAPQATEILIAILMFFS-IGFVPLDQYPEWLQPFVEHQP
Mvan_3120|M.vanbaalenii_PYR-1 VLTLALFSSSTIAPQATEIVIAILMFFS-IGFVPLDQYPKWLQPFVEHQP
MUL_2012|M.ulcerans_Agy99 VTTVALYSSQAVIVEGVELTQAIAIFFS-TGLIPLDQYPHWIQPVVAHQP
MMAR_1769|M.marinum_M VTTVALYSSQAVIVEGVELTQAIAIFFS-TGLIPLDQYPHWIQPVVAHQP
Mb2963|M.bovis_AF2122/97 VTTVALYTAQTVVVEGVELVQAIAIFFS-TGLVPLNSYPGWIQPFVAHQP
Rv2938|M.tuberculosis_H37Rv VTTVALYTAQTVVVEGVELVQAIAIFFS-TGLVPLNSYPGWIQPFVAHQP
MLBr_02350|M.leprae_Br4923 VTTVALYTEQTFVVEAVELVQAIAVFLS-TGLVPLNQYPGWIQPLVAHQP
MAV_2004|M.avium_104 VTAIAARADGKAMVTWLGAGCVVLLFLN-TGVAPAEVFPGWLQPVVRYSP
MSMEG_6510|M.smegmatis_MC2_155 SMTLAGLVRKRDRLMGIGQAITMPLFFASNALYPVDIMPTWLRWLSAVNP
MAB_1690|M.abscessus_ATCC_1997 FYLVALRTLNPQAPVAMLPLALPVLFVS-QALMPSVFLSDWLRISINANP
:* :*. .. * . *:: .*
Mflv_3387|M.gilvum_PYR-GCK VSTTIEAMKGLSLEGPIAQPVLFSVLWAAGIAAVCAVPLAIGYRRASKRG
Mvan_3120|M.vanbaalenii_PYR-1 VSTTIKAMKGLSLEGPIAQPVLLSVLWAAGIAAVCAVPLAIGFRKASKRG
MUL_2012|M.ulcerans_Agy99 VSYAVSAMRGLSMGGPVLLPMIGVLLWTAGICAVCAVPLAVGWRRASTH-
MMAR_1769|M.marinum_M VSYAVSAMRGLSMGGPVLLPMIGVLLWTAGICAVCAVPLAVGWRRASTH-
Mb2963|M.bovis_AF2122/97 VSYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH-
Rv2938|M.tuberculosis_H37Rv VSYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH-
MLBr_02350|M.leprae_Br4923 VSYAIAAMRGLSMGGPVLASMVAMLVWTAGICASCAVPLGVGYRRACTH-
MAV_2004|M.avium_104 ISPTIEAMRALAQGGPVLSPLWQAGLWGGVLVAVFAPIAVRGYRAAAEAG
MSMEG_6510|M.smegmatis_MC2_155 LSYEVNALRGLLIGTPTNWVLDITVLVAAAVLGVVAASALLRRLVR----
MAB_1690|M.abscessus_ATCC_1997 FSHIVSAASTIMYGDFDAMLVVKGVLVAIGMFALLQIPIHLVIRRKIGK-
.* : * : : : :
Mflv_3387|M.gilvum_PYR-GCK -
Mvan_3120|M.vanbaalenii_PYR-1 -
MUL_2012|M.ulcerans_Agy99 -
MMAR_1769|M.marinum_M -
Mb2963|M.bovis_AF2122/97 -
Rv2938|M.tuberculosis_H37Rv -
MLBr_02350|M.leprae_Br4923 -
MAV_2004|M.avium_104 C
MSMEG_6510|M.smegmatis_MC2_155 -
MAB_1690|M.abscessus_ATCC_1997 -