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MPSPPEESVPLPPTVGILGTGAFVPPRVVTNNQAGASAGIDDAWIFARTAIRTRRWADPEQATSDLAVQA AEQALANAAINAGQLGAVIVSTSTPDQPQPPTAAFVQNALHANSAYAFDANAVCSGFLFAINTAHALAQR DSIHVLVIGADVYSRILDPTDRKTVCLFGDGAGAVVVGPTTASSRHLRIVDTELHTFTQHINLIGVPGGG SRQPLTTATLDAGQHYFHMDGRGVRDFVTTTVPEQVRKFLARHHLAVEDIDHLVMHQANGRMLDEIYSLL DLRNATCHQTIDRFGNTGSASIPITLHHAYPELHGNILCIGFGGGMAAGITLLAAASGSAGDVGAHK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3221 | fabH_1 | - | 100% (347) | 3-oxoacyl- |
| M. marinum M | MMAR_0879 | fabH | 3e-34 | 31.48% (324) | 3-oxoacyl- |
| M. marinum M | MMAR_2474 | pks11_1 | 1e-05 | 26.40% (178) | chalcone synthase, Pks11_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0547c | fabH | 1e-33 | 29.25% (335) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. gilvum PYR-GCK | Mflv_2540 | - | 3e-12 | 23.12% (346) | Beta-ketoacyl-acyl-carrier-protein synthase I |
| M. tuberculosis H37Rv | Rv0533c | fabH | 1e-33 | 29.25% (335) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1141c | - | 1e-37 | 33.54% (325) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. avium 104 | MAV_4612 | - | 1e-32 | 28.83% (326) | 3-oxoacyl-(acyl carrier protein) synthase III |
| M. smegmatis MC2 155 | MSMEG_3953 | - | 2e-09 | 23.57% (280) | hypothetical protein MSMEG_3953 |
| M. thermoresistible (build 8) | TH_1179 | - | 7e-11 | 24.13% (315) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3531 | fabH_1 | 0.0 | 97.60% (333) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_1354 | - | 5e-08 | 24.75% (299) | 3-oxoacyl-(ACP) synthase III |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3221|M.marinum_M -------MPSPPEESVPLPPTVGILGTGAFVPPRVVTNNQAGASAGIDDA
MUL_3531|M.ulcerans_Agy99 ---------------------MGILGTAAFVPPRVVTNNQAGASAGIDDA
Mb0547c|M.bovis_AF2122/97 ---------MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDE
Rv0533c|M.tuberculosis_H37Rv ---------MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDE
MAV_4612|M.avium_104 ---------MKQISATSGPTNIGLLSVGSYRPQRAVTNDELCQNIDSSDE
MAB_1141c|M.abscessus_ATCC_199 ---------MTDIAEITGINKIGLLSLGAYRPERVVTNDEICERIESSDE
MSMEG_3953|M.smegmatis_MC2_155 --MGPHWLVMDAADEASSPFRTRIAAAGRCLPKTRLTTSELMSETRHNTH
TH_1179|M.thermoresistible__bu --MRTQWLLTEDAEADGAPFRTRLAGAGRHLPVTRLSTDDLTARTRHRTT
Mflv_2540|M.gilvum_PYR-GCK MAVDSHWLVMEGAGPR-ARYRSRLAGAGRHLPPTHLSTRDLMASTRHNTH
Mvan_1354|M.vanbaalenii_PYR-1 -----------------MTTTVSLVDVSVHLPGEPIGADHYAQFAESDDL
: . * : .
MMAR_3221|M.marinum_M WIFAR-TAIRTRRWADPEQATSDLAVQAAEQALANAAINAGQ-LGAVIVS
MUL_3531|M.ulcerans_Agy99 WIFAR-TAIRTRRWADPEQATSDLAVQAAEQALANPAINAGQ-LGAIIVS
Mb0547c|M.bovis_AF2122/97 WIYTR-TGIKTRRFAADDESAASMATEACRRALSNAGLSAAD-IDGVIVT
Rv0533c|M.tuberculosis_H37Rv WIYTR-TGIKTRRFAADDESAASMATEACRRALSNAGLSAAD-IDGVIVT
MAV_4612|M.avium_104 WIYSR-TGIKTRRFAARDESTASMATEAGREAIAKAGLEASD-IDCVVVA
MAB_1141c|M.abscessus_ATCC_199 WIYTR-TGIKTRRFAADEETAQTLAIEAGRKAIANALLTGAE-IDAVIVA
MSMEG_3953|M.smegmatis_MC2_155 IDLERLTGIRERRVSLGEDDSYSLATKAALDCLEKADRSADS-VEVVINC
TH_1179|M.thermoresistible__bu IDLERLTGIRERRISVGDEDSYSLATAAALDCLHRADRAAES-VEVVINC
Mflv_2540|M.gilvum_PYR-GCK IDLERLTGIRDRRVSTGDEDSYSLATAAAVDCLDRAGQDAAG-LDVVINC
Mvan_1354|M.vanbaalenii_PYR-1 RDNVMFRAPHLRHHVDPETSAIDMAEQAAQGLIARHGQDAVTGADVLITH
. : *: : : :* * : . . ::
MMAR_3221|M.marinum_M TSTPDQP------QPPTAAFVQNALHANSAYAFDAN-AVCSGFLFAINTA
MUL_3531|M.ulcerans_Agy99 TSTPDQP------QPPTAAFVQNALHANSAYAFDTN-AVCSGFLFAINTP
Mb0547c|M.bovis_AF2122/97 TNTHFLQ------TPPAAPMVAASLGAKGILGFDLS-AGCAGFGYALGAA
Rv0533c|M.tuberculosis_H37Rv TNTHFLQ------TPPAAPMVAASLGAKGILGFDLS-AGCAGFGYALGAA
MAV_4612|M.avium_104 TSTHFLQ------TPACGPAVAAALGATGVPAFDIS-AGCAGFGYALGVA
MAB_1141c|M.abscessus_ATCC_199 TSTHYLQ------TPASAPAVATALGAQGVPAFDLS-AGCAGFGYAVGVA
MSMEG_3953|M.smegmatis_MC2_155 SITKFHGGLTQYLEPTMSSDVAHAIGARDAMTFDIS-NACAGMLTGVMVL
TH_1179|M.thermoresistible__bu SITKFRDGLTQWLEPPMSTAVARAIGADTAMTFDLS-NACAGMLTGVSIL
Mflv_2540|M.gilvum_PYR-GCK SITKFRDGLTQWMEPTMSAAVARAIGAEHAMTFDLS-NACAGMLTGATVL
Mvan_1354|M.vanbaalenii_PYR-1 TQLPDMP------FYGAGGGMAHRLGMKPNWVIDLHNGGCAAFLLGLKLA
: . : : :* *:.: .
MMAR_3221|M.marinum_M HALAQR-DSIHVLVIGADVYSRILDPTDRKTVCLFGDGAGAVVVGPTTAS
MUL_3531|M.ulcerans_Agy99 HALAQR-DSIHVLVIGADVYSRILDPTDRKTVCLFGDSAGAVVVGPTTAS
Mb0547c|M.bovis_AF2122/97 ADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQ
Rv0533c|M.tuberculosis_H37Rv ADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQ
MAV_4612|M.avium_104 ADMVRGGTAGKVLVLGSEKLSPTVDMTDRSNCFIFADGAAGVVVGETPTQ
MAB_1141c|M.abscessus_ATCC_199 GDMIRGGSASKVLVIGSEKLSPALDMTDRGNCFIFGDGAGAVVVGETAEQ
MSMEG_3953|M.smegmatis_MC2_155 NTWIRQGLVARGMVVSGEYISQLGQNAAKHIRTVLSKELASLTLGDAGAA
TH_1179|M.thermoresistible__bu NNWIRQGVVERGMVVSGEYISQLTANAAQHIRTIMSKELASLTLGDAGAA
Mflv_2540|M.gilvum_PYR-GCK NNWIRQGTVQRGLVVSGEYISQLGQNAARHIRSIMSKELACLTLGDAGAA
Mvan_1354|M.vanbaalenii_PYR-1 RNLLASGEGRTALIAVVQNAAGQIFEQP-----TIRRRAQAAVPGDGAAI
:: : : : . *
MMAR_3221|M.marinum_M SRHLRIVDT-----ELHTFTQHINLIGVPGGGSRQPLTTATLDAGQHYFH
MUL_3531|M.ulcerans_Agy99 SRHLRIVDT-----ELHTFTQHINLIGVPGGGSRQPLTTATLDAGQHYFH
Mb0547c|M.bovis_AF2122/97 GIGPTVAGSDGE--QADAIRQDIDWITFAQNPS----------GPRPFVR
Rv0533c|M.tuberculosis_H37Rv GIGPTVAGSDGE--QADAIRQDIDWITFAQNPS----------GPRPFVR
MAV_4612|M.avium_104 GIGPTVWGSDGT--QATAIRQDIDWMDYLDRPT----------GPRPFLR
MAB_1141c|M.abscessus_ATCC_199 GIGPTVWGSDGS--QSNAIRQDIDWMDFAAAPDP--------EGPRPYLR
MSMEG_3953|M.smegmatis_MC2_155 LLLERVPAGGSG-ITLAGFTTIADYSRLCLAYPKG-------RDPGARMF
TH_1179|M.thermoresistible__bu LLLERAYPGSGS-IRLSGFTTIADHSRLCLAYPKG-------PEPGARMF
Mflv_2540|M.gilvum_PYR-GCK LLFERAPADSAAGISLAGFTTVADHSRLCLAYPKG-------DDPGARMF
Mvan_1354|M.vanbaalenii_PYR-1 GLVTVSDESPILDVECRTYGEYAGDMTIAVDPPRKWWQAGPGEGCIGFTE
.
MMAR_3221|M.marinum_M MDGRGVRDFVTTTVPEQVRKFLARHHLAVEDIDHLVMHQANGRML----D
MUL_3531|M.ulcerans_Agy99 MDGRGVRDFVTTTVPEQVRKFLARHHLAVEDIGHVVMHQANGRML----D
Mb0547c|M.bovis_AF2122/97 LEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRIN----E
Rv0533c|M.tuberculosis_H37Rv LEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRIN----E
MAV_4612|M.avium_104 LEGSAVFRWAAFEMGKVGQQAMDAAGVRPDEIDVFLPHQANSRIN----E
MAB_1141c|M.abscessus_ATCC_199 IEGTSVFRWAAFEMGKVGQRAMEAAKVGPEQIDVFVPHQANTRIN----E
MSMEG_3953|M.smegmatis_MC2_155 TDSRAIHRAAITNTPVLLREVLDTAGISIDDIDHVITHQTSARAIKKGMA
TH_1179|M.thermoresistible__bu TDSRGIQRAAIAATPVLLQEVLDQTGLSIHDIDHVITHQTSARAIRKGMR
Mflv_2540|M.gilvum_PYR-GCK TDSRGIQRAAIAATPYLLHEVLDAAGISIGDIDHVITHQTSARAIRKGMA
Mvan_1354|M.vanbaalenii_PYR-1 SKITKVLARGNRQVPEVSYAVCDRIGLPPKDVDLFVTNQPNRVFLR----
. : : ::. .: :*..
MMAR_3221|M.marinum_M EIYSLLDLR-NATCHQTIDRFGNTGSASIPITLHHAYPELHGN----ILC
MUL_3531|M.ulcerans_Agy99 EIYSLLDLR-NATCHQTIDRFGNTGSASIPITLHHAYPELHGN----ILC
Mb0547c|M.bovis_AF2122/97 LLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALL
Rv0533c|M.tuberculosis_H37Rv LLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALL
MAV_4612|M.avium_104 ILAKSLELRPDAVIANDIEHTGNTSAASIPLAMAEVLATGAAKAGDLALL
MAB_1141c|M.abscessus_ATCC_199 LLAKNLHLRADAVIANDIEHTGNTSAASVPLAMETLLSTGAAKPGDLALL
MSMEG_3953|M.smegmatis_MC2_155 VMAAEFGDHPRHDAVITVDRYGNTASTTHTVALIEELEARRIEPGETVAL
TH_1179|M.thermoresistible__bu RIADEFGGTPAHDAVITVDKYGNTASTTHTVALVDELEAGGIAPGETIAL
Mflv_2540|M.gilvum_PYR-GCK ALTESFGGGPRHDAVITVDRYGNTASTTHTVALVEELEAGRIRAGETIAL
Mvan_1354|M.vanbaalenii_PYR-1 NWREALELPPERHVD-TFDECGNLFAAGIPVNLDRAVREGRVKRGDTVLM
: .:. ** :: .: :
MMAR_3221|M.marinum_M IGFGGGMAAGITLLAAASGSAGDVGAHK
MUL_3531|M.ulcerans_Agy99 IGFGGGMAAGITLLAAASGSAGDVGAHK
Mb0547c|M.bovis_AF2122/97 IGYGAGLSYAAQVVRMPKG---------
Rv0533c|M.tuberculosis_H37Rv IGYGAGLSYAAQVVRMPKG---------
MAV_4612|M.avium_104 IGYGAGLSYAAQVVRLPPG---------
MAB_1141c|M.abscessus_ATCC_199 IGYGAGLSYAAQVVRMPPVPFE------
MSMEG_3953|M.smegmatis_MC2_155 IALASGLEIGIHLADR------------
TH_1179|M.thermoresistible__bu IALASGLEIGIVLLTLDEEMVGRHGNRG
Mflv_2540|M.gilvum_PYR-GCK IALASGLEIGVVLLTLDEELVNRYGHRD
Mvan_1354|M.vanbaalenii_PYR-1 AAFAHAGDFAAAAALRWGGRD-------
. . . .