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SANRAHDSSAPVVERVPTVDGLSLAVDFYRCDGPRAVVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDA RGHGDSDWDPDGRYDIERLGSDLLAVRAYAGSARPVAAIGASLGGLTILGTHLLAPSELWQAVVLVDITP RMQMHGARRVLSFMSAHPEGFDSLESAADVIAAYNPHRPRPENVDGLQKVLRRRGDGRWAWRWDPAFATS NFQFLQSDSDDGAEEFEMMSAFLVDGARQVSAPALLVRGLLSDIVSEETVKDFLTLVPHAQTVDVSGAGH MVAGDNNDAFSTAVVDFLDRTV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3159 | - | - | 100% (303) | hydrolase |
| M. marinum M | MMAR_4837 | - | e-114 | 65.97% (288) | hydrolase |
| M. marinum M | MMAR_4337 | bpoB | 4e-60 | 45.12% (297) | peroxidase BpoB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3502c | bpoA | 9e-55 | 46.27% (268) | peroxidase BpoA |
| M. gilvum PYR-GCK | Mflv_4622 | - | 1e-120 | 67.82% (289) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3473c | bpoA | 9e-55 | 46.27% (268) | peroxidase BpoA |
| M. leprae Br4923 | MLBr_02297 | - | 5e-10 | 27.62% (286) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2045 | - | 1e-156 | 87.13% (303) | putative hydrolase (alpha/beta fold) |
| M. avium 104 | MAV_1254 | - | 1e-63 | 48.25% (286) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_5209 | - | 6e-63 | 47.39% (287) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2112 | - | 6e-53 | 44.53% (274) | hydrolase, alpha/beta fold family protein |
| M. ulcerans Agy99 | MUL_0147 | bpoB | 3e-58 | 44.11% (297) | peroxidase BpoB |
| M. vanbaalenii PYR-1 | Mvan_0315 | - | 1e-113 | 64.97% (294) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3502c|M.bovis_AF2122/97 --------------------------------------------------
Rv3473c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3159|M.marinum_M ----------MSANRAHDSSAPVVERVPTVDGLSLAVDFYRCDGP----R
MAB_2045|M.abscessus_ATCC_1997 ----------MSAKRTGDSSAPVVERVPTADGLALAVDLYHCDAP----R
Mflv_4622|M.gilvum_PYR-GCK ------------------MTSTFER-VRNEDGTALAADVYRHESA----R
Mvan_0315|M.vanbaalenii_PYR-1 ------------------MTSAVQHRVRTQDGITLAADCYDHEDA----R
MAV_1254|M.avium_104 ------------------------MEFAGVDGITLVADEWNRGSD-GAGR
MUL_0147|M.ulcerans_Agy99 --------------MSAMSNNPRTVEFSGTEGITLVADEWNRDTA-ASGR
MSMEG_5209|M.smegmatis_MC2_155 --------------MSTAQTESQTVAFRGVDDLTLVGDEWNKGAERAADR
TH_2112|M.thermoresistible__bu --------------LNSTHSKPQTVRFRGAQGLTLVADQWNRGSG-PKDR
MLBr_02297|M.leprae_Br4923 MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPS-ATAR
Mb3502c|M.bovis_AF2122/97 --MVFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEGDYR
Rv3473c|M.tuberculosis_H37Rv --MVFLHGGGQTRRSWGRAAAAVAERGWQAVTIDLRGHGESDWSSEGDYR
MMAR_3159|M.marinum_M AVVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDARGHGDSDWDPDGRYD
MAB_2045|M.abscessus_ATCC_1997 AVVLLLHGGGQSRHAWDVTAQRLHQRGYTVAAYDTRGHGDSDWDPDGRYD
Mflv_4622|M.gilvum_PYR-GCK AVVILLHGGGQNRHAWATTARRLHARGYTVVAYDARGHGDSEWDPDGRYD
Mvan_0315|M.vanbaalenii_PYR-1 PVVLLLHGGGQNRHAWSASARRLHACGYTVVAYDTRGHGDSDWDPAGRYD
MAV_1254|M.avium_104 PSILMLHGGGQNRFSWKNTGQTLADEGLHVVALDSRGHGDSDRSPQADYQ
MUL_0147|M.ulcerans_Agy99 PTILMLHGGCQNRFSWKNTGQILADTGLHVIALDTRGHGDSDRAPDADYA
MSMEG_5209|M.smegmatis_MC2_155 PTVLLLHGGGQNRYSWKNTGQILADQGFHVIALDARGHGDSDRSPSANYS
TH_2112|M.thermoresistible__bu PTILLLHGGGQNRFSWKNTGQILADKGWHVVALDSRGHGDSDRSPTADYQ
MLBr_02297|M.leprae_Br4923 PLVMLLHGFGSFWWSWRHQLRGLTEA--RLVAVDLRGYGGSDKPPRG-YD
:::*** . :* : : * **:* *: . . *
Mb3502c|M.bovis_AF2122/97 LVSFAGDIQEVLRNLP--GQPALVGASLGGFAAMLLAGELSPGIASAVVL
Rv3473c|M.tuberculosis_H37Rv LVSFAGDIQEVLRNLP--GQPALVGASLGGFAAMLLAGELSPGIASAVVL
MMAR_3159|M.marinum_M IERLGSDLLAVRAYAGSARPVAAIGASLGGLTILGTHLLAPSELWQAVVL
MAB_2045|M.abscessus_ATCC_1997 MDRLGSDLLAVRSYADSGRPVAAIGASLGGLTILGTHLLAPPDLWQAVVL
Mflv_4622|M.gilvum_PYR-GCK LDRLASDLLSIRRYASDGRPPAVVGASLGGMTVLGTHLVAPADLWGAVVL
Mvan_0315|M.vanbaalenii_PYR-1 LERLATDLLAVREHFSAATAPAVVGASLGGMTVLGTHLLTSGASWAAVVL
MAV_1254|M.avium_104 IETLTADVLRVLDAIG--RPVTIIGASMGGLTGILAAHRAGPAKVTRLVL
MUL_0147|M.ulcerans_Agy99 IETLTSDIRHVLDAIG--RPVVLIGASMGGLTGILVADSAGPDRVTGLVL
MSMEG_5209|M.smegmatis_MC2_155 VDAMCGDVLAVLYQIS--RPVALIGASMGGLTGLLAAHEAGPERVTQLVL
TH_2112|M.thermoresistible__bu LDDLCADTLSVVDQIG--RPVSLIGASMGGLTGILVADRAGADKVTELVL
MLBr_02297|M.leprae_Br4923 GWTLAGDTAGLIRALG-HSSATLVGHAEGGLACWATALLHPR-------L
: * : :* : **:: *
Mb3502c|M.bovis_AF2122/97 VDIVPNMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSD-
Rv3473c|M.tuberculosis_H37Rv VDIVPNMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSD-
MMAR_3159|M.marinum_M VDITPRMQMHGARRVLSFMSAHPE-GFDSLESAADVIAAYNPHRPRPEN-
MAB_2045|M.abscessus_ATCC_1997 VDVTPRMEMDGARRVVAFMSAHPE-GFDSLESAADVIAAYNPHRPRPEN-
Mflv_4622|M.gilvum_PYR-GCK VDITPRMEFHGARRVVSFMGAHPD-GFDTLDAAADVIAQYNRHRARPKN-
Mvan_0315|M.vanbaalenii_PYR-1 VDVTPRLEFQGARRVVTFMAAHPD-GFGTLTDAAEVIAAYNPHRSRPAN-
MAV_1254|M.avium_104 VDVVPRFEKDGSARIRDFMISGLD-GFDSLEQAADAVAAYLPYRSKPRS-
MUL_0147|M.ulcerans_Agy99 VDVVPKYEKDGSARIRDFMFTNLH-GFATLEEAADAVATYLPHRTKPRS-
MSMEG_5209|M.smegmatis_MC2_155 VDVVPNFEKSGSARIRDFMASNVD-GFDTLEEAADAVAAYLPHRRRPRN-
TH_2112|M.thermoresistible__bu VDVVPRVEQAGTDRIRDFMMTNVA-GFETLEEAADAVAAYLPHRRRPRS-
MLBr_02297|M.leprae_Br4923 VRAIALINSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERLLTRNN
* . : . : * *: * * . .
Mb3502c|M.bovis_AF2122/97 PDGLVANLRRR-GDRWYWHWDPQFIG----GIAAFPPVEVTDVDRMN-AA
Rv3473c|M.tuberculosis_H37Rv PDGLVANLRRR-GDRWYWHWDPQFIG----GIAAFPPVEVTDVDRMN-AA
MMAR_3159|M.marinum_M VDGLQKVLRRRGDGRWAWRWDPAFATSNFQFLQSDSDDGAEEFEMMSAFL
MAB_2045|M.abscessus_ATCC_1997 LDGLRKVLARREDGRWSWRWDPAFVTSNFQFLQGDPDEGAEYFEMMSAFL
Mflv_4622|M.gilvum_PYR-GCK LDGLRKVLQQRDDGRWIWRWDPAFIASNFEFLQGDPATGAKEFGAISDLL
Mvan_0315|M.vanbaalenii_PYR-1 VDGLRKVLRQRHDGRWIWRWDPAFIHSNFDFLRDESTTGTEQFDAISHLL
MAV_1254|M.avium_104 PEGLKKNLRLR-DGRWYWHWDPAFMT----KPGDDPELRTESFEQA----
MUL_0147|M.ulcerans_Agy99 PEGLKKNLRLR-DGRWYWHWDPAMMT----APGDDPELRTENFERA----
MSMEG_5209|M.smegmatis_MC2_155 PEGLKKNLRLR-DGRWYWHWDPAFLG----KPHDDPFVRVERLEQA----
TH_2112|M.thermoresistible__bu PEGLKKNLRHR-DGRWHWHWDPAFVT----RVG-EQFVDVDVLERA----
MLBr_02297|M.leprae_Br4923 AAEIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRWAV
: : * . :* * . .
Mb3502c|M.bovis_AF2122/97 ------------VATILRDEVPVLLVRGQVSDIVRQESADQFLSRFPQVE
Rv3473c|M.tuberculosis_H37Rv ------------VATILRDEVPVLLVRGQVSDIVRQESADQFLSRFPQVE
MMAR_3159|M.marinum_M ------------VDGARQVSAPALLVRGLLSDIVSEETVKDFLTLVPHAQ
MAB_2045|M.abscessus_ATCC_1997 ------------LDGARQVSAPTLLVRGLLSDIVSEETVRHFLTVVPHAQ
Mflv_4622|M.gilvum_PYR-GCK ------------IEGARRVRAPTLLIRGVHSDVTSQQSVEEFLEVVPHAE
Mvan_0315|M.vanbaalenii_PYR-1 ------------IDGARRVSAPTLLVRGLLSDVVSQATVDEFQQLVPHAE
MAV_1254|M.avium_104 ---------------AKNLSIPVLLIRGKLSDVVSPEGVRHFLATVPRAE
MUL_0147|M.ulcerans_Agy99 ---------------AMNLTIPILLIRGKLSDVVTSEGVQDFLDKVPHAE
MSMEG_5209|M.smegmatis_MC2_155 ---------------AVNLTVPILLIRGKLSDVVSPEGVAEFLEKVPAAE
TH_2112|M.thermoresistible__bu ---------------ALRLTVPILLVRGKLSDVVSAEGVEEFLAKVPSAE
MLBr_02297|M.leprae_Br4923 RSQLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRRYAPHGR
* * :** . . * .
Mb3502c|M.bovis_AF2122/97 FTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR----------------
Rv3473c|M.tuberculosis_H37Rv FTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR----------------
MMAR_3159|M.marinum_M TVDVSGAGHMVAGDNNDAFSTAVVDFLDRTV-------------------
MAB_2045|M.abscessus_ATCC_1997 TVDVSGAGHMIAGDNNDAFSTAVVEFLDRTI-------------------
Mflv_4622|M.gilvum_PYR-GCK AVDVSGTGHMVAGDDNDAFTSAVADFLDRTLNDSSD--------------
Mvan_0315|M.vanbaalenii_PYR-1 TVDVSGTGHMIAGDDNDAFSSAVTEFLGRSILQPPP--------------
MAV_1254|M.avium_104 FVELSNAGHTAAGDDNDAFSDAVVAFVKRR--------------------
MUL_0147|M.ulcerans_Agy99 FVELSNAGHTAAGDDNDAFTEVVVDFVKRRAATG----------------
MSMEG_5209|M.smegmatis_MC2_155 FVELSDAGHTAAGDDNDAFTQVVVEFVNR---------------------
TH_2112|M.thermoresistible__bu FVELSAAXXXATIPARGSPRRCVTSPVCRRRPPTSRPAPSPRSAPRHGNV
MLBr_02297|M.leprae_Br4923 YVSVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS--------------
..: : : : :
Mb3502c|M.bovis_AF2122/97 ----------
Rv3473c|M.tuberculosis_H37Rv ----------
MMAR_3159|M.marinum_M ----------
MAB_2045|M.abscessus_ATCC_1997 ----------
Mflv_4622|M.gilvum_PYR-GCK ----------
Mvan_0315|M.vanbaalenii_PYR-1 ----------
MAV_1254|M.avium_104 ----------
MUL_0147|M.ulcerans_Agy99 ----------
MSMEG_5209|M.smegmatis_MC2_155 ----------
TH_2112|M.thermoresistible__bu AGPGANAVRR
MLBr_02297|M.leprae_Br4923 ----------