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VTKEVAVDAMVDIGGDLNKGVHQDMHSEQGARPDEHPGRSGNPIIKVVDLAWLEFEKPDLVRTEAFARAF GLQTAWRSPDELRLRGTDAGAACAIVRRAPRTRFAGVAYRACDEVDVLRLADKCGATARPLPETIGGLTV DLVDPSGMAVRVVAGMDELPALPTQQPSVLNFGHDLSRANLPQRPPRVPARIQRLGHVVVQSTRYAEALN WYLDHLGMIVSDFQFFPGQRDRGPTMSFIRCDRGSTPADHHTLAMALGPANRYLHSAYQVSDLDALAAGG EYLKERGYFRSWGIGRHIQGSQIFDYWRDPDGFLVEHFTDGDMFDNSLEPGWAPLTASGLAQWGPPATKD FLGTGPKSARHELVSMITALRATNEFDFNRLIGLLKVPSL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2985 | bphC_1 | - | 100% (390) | 2,3-dihydroxybiphenyl-1,2-dioxygenase BphC_1 |
| M. marinum M | MMAR_5063 | bphC | 3e-08 | 23.34% (317) | biphenyl-2,3-diol 1,2-dioxygenase BphC |
| M. marinum M | MMAR_1501 | - | 9e-07 | 27.04% (159) | hypothetical protein MMAR_1501 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3599c | bphC | 7e-08 | 25.66% (226) | putative biphenyl-2,3-diol 1,2-dioxygenase BPHC (23OHBP |
| M. gilvum PYR-GCK | Mflv_1465 | - | 1e-07 | 28.21% (156) | glyoxalase/bleomycin resistance protein/dioxygenase |
| M. tuberculosis H37Rv | Rv3568c | bphC | 7e-08 | 25.22% (226) | biphenyl-2,3-diol 1,2-dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2576c | - | 1e-158 | 71.47% (368) | putative 2,3-dihydroxybiphenyl-1,2-dioxygenase or |
| M. avium 104 | MAV_1802 | - | 1e-167 | 75.00% (368) | 2,3-dihydroxybiphenyl-1,2-dioxygenase |
| M. smegmatis MC2 155 | MSMEG_2006 | - | 1e-22 | 31.63% (313) | 2,3-dihydroxybiphenyl 1,2-dioxygenase |
| M. thermoresistible (build 8) | TH_1740 | - | 7e-08 | 26.79% (168) | PROBABLE BIPHENYL-2,3-DIOL 1,2-DIOXYGENASE BPHC (23OHBP |
| M. ulcerans Agy99 | MUL_4139 | bphC | 2e-08 | 23.34% (317) | biphenyl-2,3-diol 1,2-dioxygenase BphC |
| M. vanbaalenii PYR-1 | Mvan_4908 | - | 1e-163 | 73.91% (368) | glyoxalase/bleomycin resistance protein/dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1465|M.gilvum_PYR-GCK --------------------------------------------MTIKSL
TH_1740|M.thermoresistible__bu --------------------------------------------MSIRSL
Mb3599c|M.bovis_AF2122/97 --------------------------------------------MSIRSL
Rv3568c|M.tuberculosis_H37Rv --------------------------------------------MSIRSL
MUL_4139|M.ulcerans_Agy99 --------------------------------------------MSIRSL
MMAR_2985|M.marinum_M MTKEVAVDAMVDIGGDLNKGVHQDMHSEQGARPDEHPGRSGNPIIKVVDL
Mvan_4908|M.vanbaalenii_PYR-1 ---------MVKLRNDG----HKHLHSEQGARRGEHPGRSTNPLIRVADI
MAB_2576c|M.abscessus_ATCC_199 --------------MNDLIGAHNELHSEQGGLKGEHCGRARNPVIKVTDI
MAV_1802|M.avium_104 ---------MEELQMTSTVGAHNGLHSERGARKGEHPGRSRNPVIKVDDL
MSMEG_2006|M.smegmatis_MC2_155 --------------------------------------------MALHRL
: : :
Mflv_1465|M.gilvum_PYR-GCK GYLRIESTDVAAWREYGLKVLGMVEGSGPTEGALYLRMDEFPARLIIVPG
TH_1740|M.thermoresistible__bu GYLRIEATDVAAWREYGLKVLGMVEGKGPTEGALYLRMDEFPARLVIVPG
Mb3599c|M.bovis_AF2122/97 GYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARLVVVPG
Rv3568c|M.tuberculosis_H37Rv GYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARLVVVPG
MUL_4139|M.ulcerans_Agy99 GYLRIEATDMAAWREYGLKVLGMVEGKGSTEGALYLRMDDFPARLVIVPG
MMAR_2985|M.marinum_M AWLEFEKPDLVRTEAF-ARAFGLQTAWRSPDELRLRGTDAGAACAIVRRA
Mvan_4908|M.vanbaalenii_PYR-1 AWLEFDKPDLVRAEAF-ARAFGLGVASSDPRQLVLRGTDAGCPCLIVRPG
MAB_2576c|M.abscessus_ATCC_199 AWLEFEKPDLQRAEAF-ARAFGFATSLRTGEELHLRGSDSTAPCVIVRRG
MAV_1802|M.avium_104 AWLEFQKPDLVRAEAF-AHAFGFTTVLRSDDELQLRGTDAGTPCVLIRRG
MSMEG_2006|M.smegmatis_MC2_155 DSIVLGVPDLAAAATF-YEDFGLIP----HDGHRFASTEGGVQLELVHSA
: : .*: : . :*: : :: .
Mflv_1465|M.gilvum_PYR-GCK ENDRLLESGWETANAAALQDIRARLDIHGTPYKEAT---------ASQLA
TH_1740|M.thermoresistible__bu ERDRLLESGWECANAEGLQDVRSRLEAAGVPYKEGT---------AAELA
Mb3599c|M.bovis_AF2122/97 EHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEAT---------AAELA
Rv3568c|M.tuberculosis_H37Rv EHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEAT---------AAELA
MUL_4139|M.ulcerans_Agy99 TQDRLAEAGWECADAQGLQEIRNRLDVEGTPYKEAT---------AAELA
MMAR_2985|M.marinum_M PRTRFAGVAYRACDEVDVLRLADKCGATARPLPETIGGLTVDLVDPSGMA
Mvan_4908|M.vanbaalenii_PYR-1 THSRFTGVAFRAADEVDVLRLADKVHAPVQPLPEALGGVAVQLTDPSGIA
MAB_2576c|M.abscessus_ATCC_199 NRSRFLGVAFAAVDGADLLRLATATGARTRPLPAAIGGMAVDLVDPGGVP
MAV_1802|M.avium_104 PRSRFAGVAFQAADEADLRRLGKATGAPIQALPATIGGTTVDLVDPSGIP
MSMEG_2006|M.smegmatis_MC2_155 RR-RLVSARFAVDDDDDLQRAARELRRSEFAAVLPEPGRLHTVEPTTGAE
. *: : : : . .
Mflv_1465|M.gilvum_PYR-GCK DRRVDEMIIFDDPSGNTLEVFHGVALEHRRVVSPYGHKFVTEEQGLGHVV
TH_1740|M.thermoresistible__bu DRRVVELIRFQDPSGNTLEAFHTVALEHRRVVSPYGHRFVTGEQGLGHVV
Mb3599c|M.bovis_AF2122/97 DRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVV
Rv3568c|M.tuberculosis_H37Rv DRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVV
MUL_4139|M.ulcerans_Agy99 DRRVDEMILFSDPSGNPLAVFHGAALEHRRVVSPYGHKFVTGEQGLGHVV
MMAR_2985|M.marinum_M VRVVAGMDELPALPTQQPSVLNFGHDLSRANLPQRPPRVPARIQRLGHVV
Mvan_4908|M.vanbaalenii_PYR-1 VKVVGGLHELPELPTQSPLLLNTGRKTLRTNATQRPLRAPARVQRLGHVV
MAB_2576c|M.abscessus_ATCC_199 VHVVAGMHSLGALPTQALHRYNMGHDFRRINATQRPRREPTTVQRLGHLV
MAV_1802|M.avium_104 VRVVAGAHQLEALPAQTPHTFNFGHELRRANATQRPPREPARVQRLGHVV
MSMEG_2006|M.smegmatis_MC2_155 IELITAPRLDQAPYAAPPVNAPGRNDRVDARAAGIMITDRVRPRRLGHIV
. : . . : :**:*
Mflv_1465|M.gilvum_PYR-GCK LTTRDDAETLHFYRDVLGFFLRDSMKLPPQLVGRPADGAPAWLRFLGVNP
TH_1740|M.thermoresistible__bu LTTRDDAESLRFYRDVLGFYLRDSMRLPPQLVGRPADGEPAWLRFFGCNP
Mb3599c|M.bovis_AF2122/97 LSTRDDAEALHFYRDVLGFRLRDSMRLPPRMVGRPADGPPAWLRFFGCNP
Rv3568c|M.tuberculosis_H37Rv LSTRDDAEALHFYRDVLGFRLRDSMRLPPQMVGRPADGPPAWLRFFGCNP
MUL_4139|M.ulcerans_Agy99 LTTRDDAEALHFYRDVLGFKLRDSMRMPPQVVGRPADGAPAWLRFFGCNP
MMAR_2985|M.marinum_M VQSTRYAEALNWYLDHLGMIVSDFQFFPGQRDRGPTMSFIRCDR--GSTP
Mvan_4908|M.vanbaalenii_PYR-1 LQSTTYLATLNWYLDTLGMIVSDFLYFPGQRDRGPTMSFIRCDR--GDSP
MAB_2576c|M.abscessus_ATCC_199 MQSTKYLETLNWYLDTLGMIVSDFLYFPGQRDRGPTMSFIRCDR--GSTP
MAV_1802|M.avium_104 MQTTTYLQALDWYLDHLGLIVSDFLFFPGQRDRGPTMSFIRCDR--GQTP
MSMEG_2006|M.smegmatis_MC2_155 IGSPDYETAYAFFVSGLGFKVSDLVKGHG--------AFLRCST------
: : : :: . **: : * .
Mflv_1465|M.gilvum_PYR-GCK RHHSLAFMPGETPSGIVHLMVEVENSDDVGLCLDRALRRK-VKMSATLGR
TH_1740|M.thermoresistible__bu RHHSLAFMPGETPSGIVHLMVEVENSDDVGLCLDRALRRK-VPMSATLGR
Mb3599c|M.bovis_AF2122/97 RHHSLAFLPMPTSSGIVHLMVEVEQADDVGLCLDRALRRK-VPMSATLGR
Rv3568c|M.tuberculosis_H37Rv RHHSLAFLPMPTSSGIVHLMVEVEQADDVGLCLDRALRRK-VPMSATLGR
MUL_4139|M.ulcerans_Agy99 RHHSLAFLPLPTPSGIVHLMVEVQNSDDVGLCLDRALRRK-VPMSATLGR
MMAR_2985|M.marinum_M ADHHTLAMALGPANRYLHSAYQVSDLDALAAGGEYLKERG-YFRSWGIGR
Mvan_4908|M.vanbaalenii_PYR-1 ADHHTLALALGPANRYVHSAYQVSDLDALAAGGEYLRDRG-YFRSWGIGR
MAB_2576c|M.abscessus_ATCC_199 ADHHTLALALGPQNRYVHSAYQVCDLDALAAGGEYLTEQG-YFRSWGIGR
MAV_1802|M.avium_104 ADHHTLAMALGPSNRYVHSAYQVCDLDALAAGGEYLKDHG-YQRSWGIGR
MSMEG_2006|M.smegmatis_MC2_155 -DHHNVLLQRAPVPFLHHSSWQVDDVDAIGRGAMALLEDHPERHVWGLGR
.* : . * :* : * :. :**
Mflv_1465|M.gilvum_PYR-GCK HVNDKMLSFYMKTPGGFDVEFGCEGLEVD---DQNWVAREST---AVSLW
TH_1740|M.thermoresistible__bu HVNDKMLSFYMKTPGGFDVEFGCEGLQVD---DEEWVAREST---AVSLW
Mb3599c|M.bovis_AF2122/97 HVNDLMLSFYMKTPGGFDIEFGCEGRQVD---DRDWIAREST---AVSLW
Rv3568c|M.tuberculosis_H37Rv HVNDLMLSFYMKTPGGFDIEFGCEGRQVD---DRDWIAREST---AVSLW
MUL_4139|M.ulcerans_Agy99 HVNDLMLSFYMKTPGGFDVEFGCEGRQVD---DHDWIAREST---AVSLW
MMAR_2985|M.marinum_M HIQGSQIFDYWRDPDGFLVEHFTDGDMFDNSLEPGWAPLTAS---GLAQW
Mvan_4908|M.vanbaalenii_PYR-1 HIQGSQLFDYWRDPDGFLVEHFTDGDMFDNTVEPGWAPFTAT---GLAQW
MAB_2576c|M.abscessus_ATCC_199 HIQGSQLFDYWRDPDGFMVEHFTDGDLFDSTLQPGWAPFTAS---GLAQW
MAV_1802|M.avium_104 HIQGSQIFDYWRDPDGFLVEHFSDGDMFDCTLEPGWAPFTAS---GLAQW
MSMEG_2006|M.smegmatis_MC2_155 HYAGSNFFWYFKDPANNFAEYHSDMDCIVD--DALWTPEELEGARGLYQW
* . : * : * . *. : . : * . .: *
Mflv_1465|M.gilvum_PYR-GCK GHDFSVGFK--------------------------------------
TH_1740|M.thermoresistible__bu GHDFSIGFKG-------------------------------------
Mb3599c|M.bovis_AF2122/97 GHDFTVGARG-------------------------------------
Rv3568c|M.tuberculosis_H37Rv GHDFTVGARG-------------------------------------
MUL_4139|M.ulcerans_Agy99 GHDFTVGARG-------------------------------------
MMAR_2985|M.marinum_M GPPATKDFLGTGPKSARHELVSMITALRATNEFDFNRLIGLLKVPSL
Mvan_4908|M.vanbaalenii_PYR-1 GPPVSRDFLGTTPKHAPQELRSMVSALRDRNEFDLTRLIGLLKVASS
MAB_2576c|M.abscessus_ATCC_199 GPPVSKDFLGTNPKSLPHEAQSIFAALRGDNEFDINRLIGLLKVANS
MAV_1802|M.avium_104 GPPASKNFLGTNPKALPHEACSMISALRHRNEFDIHRLIGLMKVANS
MSMEG_2006|M.smegmatis_MC2_155 GPPPPASFLH--PEDLAEHMIHGHSG---------------------
* . .