For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MEELQMTSTVGAHNGLHSERGARKGEHPGRSRNPVIKVDDLAWLEFQKPDLVRAEAFAHAFGFTTVLRSD DELQLRGTDAGTPCVLIRRGPRSRFAGVAFQAADEADLRRLGKATGAPIQALPATIGGTTVDLVDPSGIP VRVVAGAHQLEALPAQTPHTFNFGHELRRANATQRPPREPARVQRLGHVVMQTTTYLQALDWYLDHLGLI VSDFLFFPGQRDRGPTMSFIRCDRGQTPADHHTLAMALGPSNRYVHSAYQVCDLDALAAGGEYLKDHGYQ RSWGIGRHIQGSQIFDYWRDPDGFLVEHFSDGDMFDCTLEPGWAPFTASGLAQWGPPASKNFLGTNPKAL PHEACSMISALRHRNEFDIHRLIGLMKVANS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1802 | - | - | 100% (381) | 2,3-dihydroxybiphenyl-1,2-dioxygenase |
| M. avium 104 | MAV_3021 | - | 1e-07 | 25.43% (291) | biphenyl-2,3-diol 1,2-dioxygenase 1 |
| M. avium 104 | MAV_0593 | - | 2e-06 | 26.42% (159) | extradiol ring-cleavage dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3599c | bphC | 4e-07 | 26.42% (159) | putative biphenyl-2,3-diol 1,2-dioxygenase BPHC (23OHBP |
| M. gilvum PYR-GCK | Mflv_4549 | - | 8e-08 | 24.66% (296) | glyoxalase/bleomycin resistance protein/dioxygenase |
| M. tuberculosis H37Rv | Rv3568c | bphC | 4e-07 | 25.79% (159) | biphenyl-2,3-diol 1,2-dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2576c | - | 1e-172 | 75.27% (376) | putative 2,3-dihydroxybiphenyl-1,2-dioxygenase or |
| M. marinum M | MMAR_2985 | bphC_1 | 1e-167 | 75.00% (368) | 2,3-dihydroxybiphenyl-1,2-dioxygenase BphC_1 |
| M. smegmatis MC2 155 | MSMEG_2006 | - | 2e-24 | 29.90% (301) | 2,3-dihydroxybiphenyl 1,2-dioxygenase |
| M. thermoresistible (build 8) | TH_4499 | - | 2e-09 | 24.15% (294) | PUTATIVE biphenyl-2,3-diol 1,2-dioxygenase 1 |
| M. ulcerans Agy99 | MUL_4139 | bphC | 5e-10 | 26.24% (282) | biphenyl-2,3-diol 1,2-dioxygenase BphC |
| M. vanbaalenii PYR-1 | Mvan_4908 | - | 1e-160 | 71.82% (369) | glyoxalase/bleomycin resistance protein/dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1802|M.avium_104 ---------MEELQMTSTVGAHNGLHSERGARKGEHPGRSRNPVIKVDDL
MAB_2576c|M.abscessus_ATCC_199 --------------MNDLIGAHNELHSEQGGLKGEHCGRARNPVIKVTDI
MMAR_2985|M.marinum_M MTKEVAVDAMVDIGGDLNKGVHQDMHSEQGARPDEHPGRSGNPIIKVVDL
Mvan_4908|M.vanbaalenii_PYR-1 ---------MVKLRNDG----HKHLHSEQGARRGEHPGRSTNPLIRVADI
Mb3599c|M.bovis_AF2122/97 -------------------------------------------MS-IRSL
Rv3568c|M.tuberculosis_H37Rv -------------------------------------------MS-IRSL
MUL_4139|M.ulcerans_Agy99 -------------------------------------------MS-IRSL
Mflv_4549|M.gilvum_PYR-GCK -------------------------------------------MSDIKSL
TH_4499|M.thermoresistible__bu ------------------------------------MRHERDTMGFIKSL
MSMEG_2006|M.smegmatis_MC2_155 --------------------------------------------MALHRL
: :
MAV_1802|M.avium_104 AWLEFQKPDLVRAEAFAH-AFGFTTVLRSDDELQLRGTDAGTPCVLIRRG
MAB_2576c|M.abscessus_ATCC_199 AWLEFEKPDLQRAEAFAR-AFGFATSLRTGEELHLRGSDSTAPCVIVRRG
MMAR_2985|M.marinum_M AWLEFEKPDLVRTEAFAR-AFGLQTAWRSPDELRLRGTDAGAACAIVRRA
Mvan_4908|M.vanbaalenii_PYR-1 AWLEFDKPDLVRAEAFAR-AFGLGVASSDPRQLVLRGTDAGCPCLIVRPG
Mb3599c|M.bovis_AF2122/97 GYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARLVVVPG
Rv3568c|M.tuberculosis_H37Rv GYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARLVVVPG
MUL_4139|M.ulcerans_Agy99 GYLRIEATDMAAWREYGLKVLGMVEGKGSTEGALYLRMDDFPARLVIVPG
Mflv_4549|M.gilvum_PYR-GCK GYVKVQATDLPRWRQFAFGVLGFAQGSGPEPDALYLRMDERAARIIVVPG
TH_4499|M.thermoresistible__bu GYVIVQATDMDRWRHFAYEVLGFAEGTGPNPEALYLRMDERTARITVEPG
MSMEG_2006|M.smegmatis_MC2_155 DSIVLGVPDLAAAATFYE-DFGLIP----HDGHRFASTEGGVQLELVHSA
: . .*: : :*: : : .
MAV_1802|M.avium_104 PRSRFAGVAFQAADEADLRRLGKATGAPIQALPATIGGTTVDLVDPSGIP
MAB_2576c|M.abscessus_ATCC_199 NRSRFLGVAFAAVDGADLLRLATATGARTRPLPAAIGGMAVDLVDPGGVP
MMAR_2985|M.marinum_M PRTRFAGVAYRACDEVDVLRLADKCGATARPLPETIGGLTVDLVDPSGMA
Mvan_4908|M.vanbaalenii_PYR-1 THSRFTGVAFRAADEVDVLRLADKVHAPVQPLPEALGGVAVQLTDPSGIA
Mb3599c|M.bovis_AF2122/97 EHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEAT---------AAELA
Rv3568c|M.tuberculosis_H37Rv EHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEAT---------AAELA
MUL_4139|M.ulcerans_Agy99 TQDRLAEAGWECADAQGLQEIRNRLDVEGTPYKEAT---------AAELA
Mflv_4549|M.gilvum_PYR-GCK DVDRIVTAGWEVRDRRGLEAVMRALDAAGTPFKELS---------LAEAD
TH_4499|M.thermoresistible__bu EVDRIVTIGWEVRDHAALEDVKRALAAAGVPHRQLS---------TAEAD
MSMEG_2006|M.smegmatis_MC2_155 RR-RLVSARFAVDDDDDLQRAARELRRSEFAAVLPEPGRLHTVEPTTGAE
*: : : : .
MAV_1802|M.avium_104 VRVVAGAHQLEALPAQTPHTFNFGHELRRANATQRPPREPARVQRLGHVV
MAB_2576c|M.abscessus_ATCC_199 VHVVAGMHSLGALPTQALHRYNMGHDFRRINATQRPRREPTTVQRLGHLV
MMAR_2985|M.marinum_M VRVVAGMDELPALPTQQPSVLNFGHDLSRANLPQRPPRVPARIQRLGHVV
Mvan_4908|M.vanbaalenii_PYR-1 VKVVGGLHELPELPTQSPLLLNTGRKTLRTNATQRPLRAPARVQRLGHVV
Mb3599c|M.bovis_AF2122/97 DRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVV
Rv3568c|M.tuberculosis_H37Rv DRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVV
MUL_4139|M.ulcerans_Agy99 DRRVDEMILFSDPSGNPLAVFHGAALEHRRVVSPYGHKFVTGEQGLGHVV
Mflv_4549|M.gilvum_PYR-GCK ARRVEEVIAFEDPAGNSLEVFHGAVLDHSPVVTPYGARFVTGAQGLGHVV
TH_4499|M.thermoresistible__bu ARRVEEVVAFADPAGTALEVFHGPVLDHSPVVTPFGARFVTGDQGLGHVV
MSMEG_2006|M.smegmatis_MC2_155 IELITAPRLDQAPYAAPPVNAPGRNDRVDARAAGIMITDRVRPRRLGHIV
. : . . : :**:*
MAV_1802|M.avium_104 MQTTTYLQALDWYLDHLGLIVSDFLFFPGQR-DRGPTMSFIRCDRGQTPA
MAB_2576c|M.abscessus_ATCC_199 MQSTKYLETLNWYLDTLGMIVSDFLYFPGQR-DRGPTMSFIRCDRGSTPA
MMAR_2985|M.marinum_M VQSTRYAEALNWYLDHLGMIVSDFQFFPGQR-DRGPTMSFIRCDRGSTPA
Mvan_4908|M.vanbaalenii_PYR-1 LQSTTYLATLNWYLDTLGMIVSDFLYFPGQR-DRGPTMSFIRCDRGDSPA
Mb3599c|M.bovis_AF2122/97 LSTRDDAEALHFYRDVLGFRLRDSMRLPPRMVGRPADGPPAWLRFFGCNP
Rv3568c|M.tuberculosis_H37Rv LSTRDDAEALHFYRDVLGFRLRDSMRLPPQMVGRPADGPPAWLRFFGCNP
MUL_4139|M.ulcerans_Agy99 LTTRDDAEALHFYRDVLGFKLRDSMRMPPQVVGRPADGAPAWLRFFGCNP
Mflv_4549|M.gilvum_PYR-GCK IPALDVNGLFDFYTQVLGFKSRGAFRVP-----TPPEYGPVRVRFLGVNQ
TH_4499|M.thermoresistible__bu LPTVDVDGLFEFYTEVLGFRSRGAFRVP-----APEEFGPVRVRFLGINE
MSMEG_2006|M.smegmatis_MC2_155 IGSPDYETAYAFFVSGLGFKVSDLVKGHG---------AFLRCS-----T
: : :: . **: .
MAV_1802|M.avium_104 DHHTLAMALGPSN---RYVHSAYQVCDLDALAAGGEYLKDHG-YQRSWGI
MAB_2576c|M.abscessus_ATCC_199 DHHTLALALGPQN---RYVHSAYQVCDLDALAAGGEYLTEQG-YFRSWGI
MMAR_2985|M.marinum_M DHHTLAMALGPAN---RYLHSAYQVSDLDALAAGGEYLKERG-YFRSWGI
Mvan_4908|M.vanbaalenii_PYR-1 DHHTLALALGPAN---RYVHSAYQVSDLDALAAGGEYLRDRG-YFRSWGI
Mb3599c|M.bovis_AF2122/97 RHHSLAFLPMPTS--SGIVHLMVEVEQADDVGLCLDRALRRK-VPMSATL
Rv3568c|M.tuberculosis_H37Rv RHHSLAFLPMPTS--SGIVHLMVEVEQADDVGLCLDRALRRK-VPMSATL
MUL_4139|M.ulcerans_Agy99 RHHSLAFLPLPTP--SGIVHLMVEVQNSDDVGLCLDRALRRK-VPMSATL
Mflv_4549|M.gilvum_PYR-GCK RHHSLAICPAATVRDPKLVHLMVEVDTLDAVGQALDRVHKDG-FQLSSTL
TH_4499|M.thermoresistible__bu RHHSLALCPASTLRDPGLIHLMVEVDTLDAVGQALDRVNRDG-YQLSSTL
MSMEG_2006|M.smegmatis_MC2_155 DHHNVLLQRAPVP---FLHHSSWQVDDVDAIGRGAMALLEDHPERHVWGL
**.: : . * :* * :. :
MAV_1802|M.avium_104 GRHIQGSQIFDYWRDPDGFLVEHFSDGDMFDCTLEPGWAPFTAS---GLA
MAB_2576c|M.abscessus_ATCC_199 GRHIQGSQLFDYWRDPDGFMVEHFTDGDLFDSTLQPGWAPFTAS---GLA
MMAR_2985|M.marinum_M GRHIQGSQIFDYWRDPDGFLVEHFTDGDMFDNSLEPGWAPLTAS---GLA
Mvan_4908|M.vanbaalenii_PYR-1 GRHIQGSQLFDYWRDPDGFLVEHFTDGDMFDNTVEPGWAPFTAT---GLA
Mb3599c|M.bovis_AF2122/97 GRHVNDLMLSFYMKTPGGFDIEFGCEGRQVD---DRDWIAREST---AVS
Rv3568c|M.tuberculosis_H37Rv GRHVNDLMLSFYMKTPGGFDIEFGCEGRQVD---DRDWIAREST---AVS
MUL_4139|M.ulcerans_Agy99 GRHVNDLMLSFYMKTPGGFDVEFGCEGRQVD---DHDWIAREST---AVS
Mflv_4549|M.gilvum_PYR-GCK GRHTNDKMVSFYVRAPGDWDIELGTEGMLVD---ESSYTAEEIT---ADS
TH_4499|M.thermoresistible__bu GRHTNDKMVSFYVRAPGDWDIEFGTAGMRVD---ETYYTAEEIT---ADS
MSMEG_2006|M.smegmatis_MC2_155 GRHYAGSNFFWYFKDPANNFAEYHSDMDCIVD--DALWTPEELEGARGLY
*** . . * : * . * . : : . .
MAV_1802|M.avium_104 QWGPPASKNFLGTNPKALPHEACSMISALRHRNEFDIHRLIGLMKVANS
MAB_2576c|M.abscessus_ATCC_199 QWGPPVSKDFLGTNPKSLPHEAQSIFAALRGDNEFDINRLIGLLKVANS
MMAR_2985|M.marinum_M QWGPPATKDFLGTGPKSARHELVSMITALRATNEFDFNRLIGLLKVPSL
Mvan_4908|M.vanbaalenii_PYR-1 QWGPPVSRDFLGTTPKHAPQELRSMVSALRDRNEFDLTRLIGLLKVASS
Mb3599c|M.bovis_AF2122/97 LWG----HDFTVGARG---------------------------------
Rv3568c|M.tuberculosis_H37Rv LWG----HDFTVGARG---------------------------------
MUL_4139|M.ulcerans_Agy99 LWG----HDFTVGARG---------------------------------
Mflv_4549|M.gilvum_PYR-GCK YWG----HEWVTDLPIAMQP-----------------------------
TH_4499|M.thermoresistible__bu YWG----HQWVGDLPAAMRP-----------------------------
MSMEG_2006|M.smegmatis_MC2_155 QWGPPPPASFLHPEDLAEHMIHGHSG-----------------------
** .: