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NAETAWAEAMKFENRPNPYPYFDELRKTPVAKVAEKTYVVTGYRELLALAHDPRISSDITRSPSGFGGEA PQPEPGSEHVQAYGQDASIIVSDPPDHDRARRQVMRHFAPPHSPDLIPSMEPFVVRLANDLLNQASARGS TRLDVVEDFAYPIPVAVICKILGVPIEDEPKFHAWIFDFMAGTDLGPEGDTEEGQVLAEKGRVSTAALTD YLGDLVRSYAKTPGEGLLSKLLHDDGPDGPMSVPETTANALLLLVAGHDSTVNTITNCVMTLLRNPGSWD LVRQRPELIPRTIEEVQRLQSAVQFFPSRSATDEIEIGGTVIPAGSAVHLIYAAANRDPRRFDNPNRFDP LREDNEHFGWGSGIHTCMGGPLARLEVNLAVEIFLRRVQSPKLVVDPPPYRHNQIFRGPRHLWVDFAAIT E*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2930 | cyp147G1 | - | 100% (422) | cytochrome P450 147G1 Cyp147G1 |
| M. marinum M | MMAR_5268 | cyp164A3 | 3e-51 | 33.33% (402) | cytochrome P450 164A3 Cyp164A3 |
| M. marinum M | MMAR_4833 | cyp123B1 | 2e-36 | 30.16% (378) | cytochrome P450 123B1 Cyp123B1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 2e-35 | 31.05% (380) | cytochrome p450 140 CYP140 |
| M. gilvum PYR-GCK | Mflv_1229 | - | 3e-56 | 35.06% (405) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1880c | cyp140 | 2e-35 | 31.05% (380) | cytochrome p450 140 CYP140 |
| M. leprae Br4923 | MLBr_02088 | - | 7e-50 | 35.71% (322) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 2e-48 | 33.66% (410) | cytochrome P450 |
| M. avium 104 | MAV_0358 | - | 5e-61 | 36.03% (408) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_6312 | - | 2e-55 | 35.26% (397) | cytochrome P450 107B1 |
| M. thermoresistible (build 8) | TH_3048 | - | 1e-41 | 32.91% (395) | PUTATIVE putative phosphomannomutase/phosphoglucomutase |
| M. ulcerans Agy99 | MUL_2979 | cyp140A5 | 1e-36 | 31.58% (380) | cytochrome P450 140A5 Cyp140A5 |
| M. vanbaalenii PYR-1 | Mvan_0401 | - | 1e-169 | 68.74% (419) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2930|M.marinum_M -------------------------------MNAETAWAEAMKFENRPNP
Mvan_0401|M.vanbaalenii_PYR-1 ------------------------------MTTASQAWAQAMAFAHRADP
Mflv_1229|M.gilvum_PYR-GCK ---------------------------MTTAAEPQSLLLQMLDPANRADP
MSMEG_6312|M.smegmatis_MC2_155 -------------------MHNGWMSTAATAQEAQGLLLQLLDPATRADP
MAV_0358|M.avium_104 -----------------------MTTAPTESAESQGLLLQLLDPANRADP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
MAB_0276|M.abscessus_ATCC_1997 ---------------------------MPITTDPGTLLLQVLDPANRANP
Mb1912c|M.bovis_AF2122/97 ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
Rv1880c|M.tuberculosis_H37Rv ---------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDP
MUL_2979|M.ulcerans_Agy99 ---------MKDKLHWFAMHGVIRGMANIGLRRGELEARLIADPAVAANP
TH_3048|M.thermoresistible__bu --------MATTQTGNFTANLVKVGVDSLGGVVQDTVIARVKRRNGANDP
:*
MMAR_2930|M.marinum_M YPYFDELRKTP-VAKVAEKTYVVTGYRELLALAHDPRISSDITRSPSGFG
Mvan_0401|M.vanbaalenii_PYR-1 YPFFAELRKTP-VARVADDLYVVTGYYELLALAHDPRVSSDFRRSP--LS
Mflv_1229|M.gilvum_PYR-GCK YPLYARIRAQ---GPVQLPANNLTVFSTYAA---CDEILRHPHASSDRLK
MSMEG_6312|M.smegmatis_MC2_155 YPIYDRIRRG---GPLALPEANLAVFSSFSD---CDDVLRHPSSCSDRTK
MAV_0358|M.avium_104 YRLYAQFRER---GALQLPEANLAVFLSYRD---CDEVLRHPSSSSDNVN
MLBr_02088|M.leprae_Br4923 FPVYRALIDY---GPMQLPGMPLTVFSSFSD---CDEALRHPLSASDRLK
MAB_0276|M.abscessus_ATCC_1997 YPVYGQLVEQTQAGPVHPPGMDVSVLATFAD---CNAVLRHPQASSDRRK
Mb1912c|M.bovis_AF2122/97 VPFYDEVRSHG--ALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPP
Rv1880c|M.tuberculosis_H37Rv VPFYDEVRSHG--ALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPP
MUL_2979|M.ulcerans_Agy99 GPFHDELRRHG--RMVRTRVNYLTVDYQLAHDVLRSDDFHTISFGENLPG
TH_3048|M.thermoresistible__bu VTRFNPFADAVISNPYPAYRELLAGPPVRYNPRLGIWIVPRFTDVRAGLR
. . ::
MMAR_2930|M.marinum_M GEAPQPEPGSEHVQAYGQDASIIVSDPPDHDRARRQVMRHFAPPHSPDLI
Mvan_0401|M.vanbaalenii_PYR-1 SDRAPAEP-ADDVGAYGSEPSLIVTDPPSHDRARRQVSRHFAPPHSPDLI
Mflv_1229|M.gilvum_PYR-GCK STLAQRAIADGAQPRPFGPPGFLFLDPPDHTRLRRLVSKAFVP----KVV
MSMEG_6312|M.smegmatis_MC2_155 STIFQRQLAAETQPRPQGPASFLFLDPPDHTRLRGLVSKAFAP----RVI
MAV_0358|M.avium_104 STVAKRQAAAGTAPVRQGPPGFLFLDPPDHTRLRRLVSKAFAP----RVV
MLBr_02088|M.leprae_Br4923 ATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAP----KVV
MAB_0276|M.abscessus_ATCC_1997 SNIVQRQLAQ--NPNLIARPSFLGLDAPDHTRLRKLASKAFAP----RVI
Mb1912c|M.bovis_AF2122/97 PLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTS----RAV
Rv1880c|M.tuberculosis_H37Rv PLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTS----RAV
MUL_2979|M.ulcerans_Agy99 PLRWLERRTRDEQLHPLRPPSLLAVEPPDHTRYRKTVSAVFTS----RAV
TH_3048|M.thermoresistible__bu DHT-KLSSAQSQSRFRVELPMMITKDPPDHTRLRGLVSRAFTP----RAL
. :: :.*.* * * . *.. :
MMAR_2930|M.marinum_M PSMEPFVVRLANDLLNQASARGSTRLDVVEDFAYPIPVAVICKILGVPIE
Mvan_0401|M.vanbaalenii_PYR-1 PSMEPAVVALCNDLLDTAKANGRTRIDVVDDYAYPVPVMVICKILGVPLE
Mflv_1229|M.gilvum_PYR-GCK KALEPEIVALVDALLA-DAGG---TFDAIEGLAYPLPVAVICRLLGVPLA
MSMEG_6312|M.smegmatis_MC2_155 KRLEPEITALVDQLLD-AVDGP--EFNLIDNLAYPLPVAVICRLLGVPIE
MAV_0358|M.avium_104 AALEPDIRSLVDGLLDRAADRG--ELEIVEDFAYPLPVAVICRLLGVPLD
MLBr_02088|M.leprae_Br4923 QALEGDIAALVDSLLDKGAAAG--QFDVIADLAFPLAVAVICRLLGVPYE
MAB_0276|M.abscessus_ATCC_1997 NAMAEDIQTFVDKMLDDIALRG--TFNLVTEFAYPLPVAVICRMLGVPIE
Mb1912c|M.bovis_AF2122/97 SALRDLVEQTAINLLDRFAEQPG-IVDVVGRYCSQLPIVVISEILGVPEH
Rv1880c|M.tuberculosis_H37Rv SALRDLVEQTAINLLDRFAEQPG-IVDVVGRYCSQLPIVVISEILGVPEH
MUL_2979|M.ulcerans_Agy99 AALRDRVEQTANSLLDQLAQRPG-VVDVVGQYCSQLPIMVISEILGVPEQ
TH_3048|M.thermoresistible__bu AMWEAVIEQHTDLLLDRMIAMEA--PDGVHDLAQLLPTRLIASMFDIPEA
: :* : : . :. :*. ::.:*
MMAR_2930|M.marinum_M DEPKFHAWIFDFMAGTDLGPEGDTEEGQVLAEKGRVSTAALTDYLGDLVR
Mvan_0401|M.vanbaalenii_PYR-1 DEPRFHAWIFDMLAGVDLGPDATTDEGQGRAARARDAQAALRDYLAGLIE
Mflv_1229|M.gilvum_PYR-GCK DEPEFSAASALLAQSLDPFATVTGSAGDGFEER-MEAARWLRGYLRELIS
MSMEG_6312|M.smegmatis_MC2_155 DEPKFSRASALLAAALDPFLALTGETSDLFDEQ-MKAGMWLRDYLRALID
MAV_0358|M.avium_104 DEPQFSRASALLAQALDPFSTITGVPAEVASER-QQAGTWLRDYFHQLIE
MLBr_02088|M.leprae_Br4923 DAPEFGRVSALLVQSVDPFITITGEPPEATEER-LRAGVWLRDYLEQLVK
MAB_0276|M.abscessus_ATCC_1997 DEPEFGRASALLGQGLDPVYALTGQSPANMDER-FQAARWMWDYFIDLIA
Mb1912c|M.bovis_AF2122/97 DRPRVLEFGELAAPSLD-----IGIPWRQYLRV-QQGIRGFDCWLEGHLQ
Rv1880c|M.tuberculosis_H37Rv DRPRVLEFGELAAPSLD-----IGIPWRQYLRV-QQGIRGFDCWLEGHLQ
MUL_2979|M.ulcerans_Agy99 DRGRVLEYGELAAPSLD-----IGVTYRQYRRI-QQGITGFNSWLTAHLE
TH_3048|M.thermoresistible__bu DHAKFRSWSEALIDGSF---VEVGRRTFGVVQRMVRATFAMRRYLQPLFE
* .. . . : :: .
MMAR_2930|M.marinum_M SYAKTPGEGLLSKLLHDD-GPDGP--MSVPETTANALLLLVAGHDSTVNT
Mvan_0401|M.vanbaalenii_PYR-1 GYRGAGGDGLLSALVNDASGPDGA--MPPGQALANAVLLLIAGHDSTVNT
Mflv_1229|M.gilvum_PYR-GCK QRRRDPGEDLMSGLIQVEESGD---QLTEDEIVATCNLLLVAGHETTVNL
MSMEG_6312|M.smegmatis_MC2_155 ERRRTPGEDLMSGLVAVEESGD---QLTEDEIIATCNLLLIAGHETTVNL
MAV_0358|M.avium_104 ARRSRPGDDLLSGLIAVEESGD---QLTEEEIVSTCNLLLIAGHETTVNL
MLBr_02088|M.leprae_Br4923 CRRGTPGEDLISRLIELDESGD---QLTEEEIIATCGLLLVAGHETTVNL
MAB_0276|M.abscessus_ATCC_1997 SRRRNLGDDLLSALIQVEEAGD---QLTEEEIISTCTLLLIAGHETTVNL
Mb1912c|M.bovis_AF2122/97 QLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNL
Rv1880c|M.tuberculosis_H37Rv QLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNL
MUL_2979|M.ulcerans_Agy99 QLRRNPGDDLMSQLIRVAESGDAGTYLDKSELRAIAGLVLVAGFETTVNL
TH_3048|M.thermoresistible__bu ERRHHPGTDLISLMLLSEDGDR----LTDDEIFWGVVMLIVAGNETTTNL
* .*:* :: . : : ::::** ::*.*
MMAR_2930|M.marinum_M ITNCVMTLLRNPGSWDLVRQRPELIPRTIEEVQRLQSAVQFFPSRSATDE
Mvan_0401|M.vanbaalenii_PYR-1 ISNCVLTFLRNPGTVELLRDRPELIPRAIEEVQRLQSAVQFFPSRSATAD
Mflv_1229|M.gilvum_PYR-GCK IANAILALLSNDGQWSALAADPARVGAVVEETLRYDPPVQLVG-RIAAED
MSMEG_6312|M.smegmatis_MC2_155 IANAALAMLRTPGQWAALAADGSRASAVIEETMRYDPPVQLVS-RYAGDD
MAV_0358|M.avium_104 IGNAVLAMLRDPGQWAALGADPGRAPAIVEETLRYDPPVQLAG-QIALDD
MLBr_02088|M.leprae_Br4923 IANAVLAMLRNPSQWKALSSNPQRAPLVVEETLRYDPAIHLIG-RVAAKD
MAB_0276|M.abscessus_ATCC_1997 IANASLAMLRHPEQWKLLGQNADRAPLVVEETLRYDPPVHMVA-RVADGE
Mb1912c|M.bovis_AF2122/97 LGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTA-RVACRD
Rv1880c|M.tuberculosis_H37Rv LGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTA-RVACRD
MUL_2979|M.ulcerans_Agy99 LGNGIRMLLDAPEQLETLRQRPELWPNAVEEILRLDSPVQLTA-RVARTD
TH_3048|M.thermoresistible__bu LGWLLHTFALRPDVYDTVRARPELIPSLIEEQLRFESPVQGFY-RTATSD
: : : :** * :..:: : * :
MMAR_2930|M.marinum_M IEIGGTVIPAGSAVHLIYAAANRDPRRFDNPNRFDPLREDN-EHFGWGSG
Mvan_0401|M.vanbaalenii_PYR-1 IEVGGTVIPEGAAVHLMYGAANRDPRRFADPDTFDIFRPDN-EHFGWGSG
Mflv_1229|M.gilvum_PYR-GCK MTVGTTTVPKGDNMLLLTAAAHRDPDAVDRPDEFDPDRESF-RHLGFGKG
MSMEG_6312|M.smegmatis_MC2_155 LTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDRAQI-RHLGFGKG
MAV_0358|M.avium_104 MVIGGVEVPAGDVMMLLLAAANRDPAEFDRPDTFDPDRKSL-RHLGFGRG
MLBr_02088|M.leprae_Br4923 MTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAVG
MAB_0276|M.abscessus_ATCC_1997 MAIRDFILPDGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEI-KHLAFGHG
Mb1912c|M.bovis_AF2122/97 VEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTG
Rv1880c|M.tuberculosis_H37Rv VEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTG
MUL_2979|M.ulcerans_Agy99 VEIASWPINRGEMVVAYLAGANRDPAVFPNPHRFDVERANAGRHLAFSTG
TH_3048|M.thermoresistible__bu YPIGDHVIPRQSRVLLLFAAANRDPRHFDDPNTFRPDRDPN-DHLAFGGG
: : : ..*:*** . * * *:.:. *
MMAR_2930|M.marinum_M IHTCMGGPLARLEVNLAVEIFLRRVQSPKLVVDPPPYRHNQIFRGPRHLW
Mvan_0401|M.vanbaalenii_PYR-1 IHTCVGGPLARLEVNLALEIFLRRVHRPRLVSDPPPYRQSQIFRGPRHVL
Mflv_1229|M.gilvum_PYR-GCK PHFCIGAPLARLEAAVALTALTSRFPGAQLA-GEPSYKQNVTLRGMSELP
MSMEG_6312|M.smegmatis_MC2_155 AHFCLGAPLARLEATVALPALAARFPEARLS-GEPEYKRNLTLRGMSTLS
MAV_0358|M.avium_104 VHYCLGAPLARLEAGVALSAVTARFPRARLD-GEPQYKTNVTLRGLSRLV
MLBr_02088|M.leprae_Br4923 SHFCLGAALARLEATVTLSAISARFPQVQLA-GELVYKPNVAMRGMSALP
MAB_0276|M.abscessus_ATCC_1997 PHFCLGAPLARLEARLALSSITARFPGARLM-DEPTYKPNVTLRGLAELP
Mb1912c|M.bovis_AF2122/97 RHFCLGAALARAEGEVGLRTFFDRFPDVRAA-GAGSRRDTRVLRGWSTLP
Rv1880c|M.tuberculosis_H37Rv RHFCLGAALARAEGEVGLRTFFDRFPDVRAA-GAGSRRDTRVLRGWSTLP
MUL_2979|M.ulcerans_Agy99 RHFCLGAALARAEGEVGLRTFFERFPDVRAA-GAGSRRDTRVLRGWSTLP
TH_3048|M.thermoresistible__bu VHFCLGAGLSRLEARHVVAHLTQRVAAVHLA-GTPRRLHNATMHGWTSLP
* *:*. *:* * : . *. : . . ::* :
MMAR_2930|M.marinum_M VDFAAITE----
Mvan_0401|M.vanbaalenii_PYR-1 VDVEAIGD----
Mflv_1229|M.gilvum_PYR-GCK ITL---------
MSMEG_6312|M.smegmatis_MC2_155 IAV---------
MAV_0358|M.avium_104 VAV---------
MLBr_02088|M.leprae_Br4923 VQV---------
MAB_0276|M.abscessus_ATCC_1997 VSIA--------
Mb1912c|M.bovis_AF2122/97 VTLGPARSMVSP
Rv1880c|M.tuberculosis_H37Rv VTLGPARSMVSP
MUL_2979|M.ulcerans_Agy99 VTLGPARALAAS
TH_3048|M.thermoresistible__bu LRLKPA------
: .