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VTDYDAIVVGAGHNGLTAAAVLQRAGLRTLCMEANTYTGGMAATVELIDGFHFEIAGSVQFPTASQISKE LGLDTLPTVAPEVMSTNIGESSEEAMIFYRDPLQLISHLGEKHGSAAVTGMAELIGWSQGPARALGRFEV RTPPRTLDEMYACATNQAERRAIHEMLFGSAMDVIDRFLPDKEKHAVMRGMLAFLAVNSTYRGPFTPGSA ACLAFALAVPDDSTAMMTKLRGGIGALTDHLRELFASAGGEIRFRSKVVEIVVDRGAVSGVRLPDGSVIS TPVVVSNLAPDVTLAKLVGPEHVGADLLARLAGRDHRASFVQIHFALDALPEFAPPYELLNEPGMQQSVG IFGTPEEQQQQWETCRRGIVPENPSMGMQIPSVHDSGLAPPGKHAASAYAYAFPVEVGRDQHGHLKRLMA QRVIDKITRFAPNFKDIVIRYITFAPYHMQTMFGAPSGDFCHGLLHPDLMGPNRPGPKGFLDFPIPIDGL YLGGAGCHGGPGITFIPGYNAAYQVLEDVATRQTSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2813 | - | - | 100% (526) | dehydrogenase |
| M. marinum M | MMAR_5383 | - | 0.0 | 61.26% (524) | dehydrogenase |
| M. marinum M | MMAR_4639 | - | 7e-12 | 25.88% (313) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 0.0 | 60.11% (524) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1677 | - | 0.0 | 61.58% (518) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3829c | - | 0.0 | 60.31% (524) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0948c | - | 5e-08 | 21.23% (537) | hypothetical protein MAB_0948c |
| M. avium 104 | MAV_2787 | - | 0.0 | 80.92% (519) | FAD dependent oxidoreductase, putative |
| M. smegmatis MC2 155 | MSMEG_0664 | - | 6e-44 | 29.18% (538) | FAD dependent oxidoreductase |
| M. thermoresistible (build 8) | TH_4571 | - | 2e-06 | 24.75% (299) | PUTATIVE dehydrogenase |
| M. ulcerans Agy99 | MUL_2934 | - | 0.0 | 98.10% (526) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0988 | - | 0.0 | 74.71% (518) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3859c|M.bovis_AF2122/97 ----------------------MTGYDAIVIGAGHNGLTAAVLLQRAGLR
Rv3829c|M.tuberculosis_H37Rv ----------------------MTGYDAIVIGAGHNGLTAAVLLQRAGLR
Mflv_1677|M.gilvum_PYR-GCK ----------------------MTDFDAIVVGAGHNGLTAAALLQQAGLR
MMAR_2813|M.marinum_M ----------------------MTDYDAIVVGAGHNGLTAAAVLQRAGLR
MUL_2934|M.ulcerans_Agy99 ----------------------MTDYDAIVVGAGHNGLTAAAVLQRAGLR
MAV_2787|M.avium_104 --------------------MSDTNYDAIVVGAGHNGLTAAAILQRAGLR
Mvan_0988|M.vanbaalenii_PYR-1 ----------------------MSDYDAIIIGAGHNGLTAATVLQRAGLR
MSMEG_0664|M.smegmatis_MC2_155 ---------------------MSNNYDALVIGGGHNGLVSAAYLARAGAR
MAB_0948c|M.abscessus_ATCC_199 -----------------MGLSESDRYDTVIVGGGHNALTAAAYLARAGQR
TH_4571|M.thermoresistible__bu VAAERSGADHGHLVPVPRRAGGGGVTTATVVGSGPNGLAAAVTLAKAGVA
: ::*.* *.*.:*. * :**
Mb3859c|M.bovis_AF2122/97 TACLDAKRYAGGMASTVELFDG---YRFDIAGSVQFPTSSAVSSELGLDS
Rv3829c|M.tuberculosis_H37Rv TACLDAKRYAGGMASTVELFDG---YRFEIAGSVQFPTSSAVSSELGLDS
Mflv_1677|M.gilvum_PYR-GCK TVCLDFKLYAGGMASTVELFDG---FRFEIAGSVQVPTSAVVSDALELGD
MMAR_2813|M.marinum_M TLCMEANTYTGGMAATVELIDG---FHFEIAGSVQFPTASQISKELGLDT
MUL_2934|M.ulcerans_Agy99 TLCMEANTYAGGMAATVELIDG---FHFEIAGSVQFPTASQISKELGLDT
MAV_2787|M.avium_104 TVCLEANTYAGGMAATVELIDG---FRYEIAGSVQFPMAAQLAKDLGLDT
Mvan_0988|M.vanbaalenii_PYR-1 TVLLEANTYAGGMAATVELIDG---FRYEIAGSVQFPTPAVVAKELGLDQ
MSMEG_0664|M.smegmatis_MC2_155 TLVLESRSSLGGAATTEAPWDDAPHLRVTRLSYVMSLMPPTIVRDLALER
MAB_0948c|M.abscessus_ATCC_199 VMLLERLDVFGGAAISAPAFEG-VEARLSRYSYLVSLMPRQIIDDLGLDV
TH_4571|M.thermoresistible__bu VTVLEAADEIGGGTRSFEAIVPG-LLHDHCSAIHPMAVGSPFINEFGLDR
. :: ** : : : . . : *
Mb3859c|M.bovis_AF2122/97 LPTVDLEVMSVALRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLL
Rv3829c|M.tuberculosis_H37Rv LPTVDLEVMSVALRGVGDDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLL
Mflv_1677|M.gilvum_PYR-GCK LPTVDLDVMSVQLRGVGDDPLVYYTDPMKLLTHLNDVHGAEAVNGMAGLM
MMAR_2813|M.marinum_M LPTVAPEVMSTNIGESSEEAMIFYRDPLQLISHLGEKHGSAAVTGMAELI
MUL_2934|M.ulcerans_Agy99 LPTVAPEVMSTNIGESDEEAMIFYRDPLQLISHLGEKHGSAAVTGMAELI
MAV_2787|M.avium_104 LPAVEPDVMSTNIGEHGEEPMIFYRDLVRLMTHLSDKHGLNAVTGMADLI
Mvan_0988|M.vanbaalenii_PYR-1 LPTVDTEVMSVNLGDDGDEPMIFYRDPMQFMTHLAEKHGADAVAGMAGLL
MSMEG_0664|M.smegmatis_MC2_155 HGYKVHPMGPYYQAFPEGGSLTIYEDDPARTYEQLSRFSKKDADAWPKWN
MAB_0948c|M.abscessus_ATCC_199 R-LARRKYASYTPDPMNGGQRGFLAGP----------------NDFAEFG
TH_4571|M.thermoresistible__bu HGLRWRWPDIDCVHPLDDGTAGVLRRSVDHTAAGLGPDGRVWRALFGRPV
Mb3859c|M.bovis_AF2122/97 AWSQAPTRALGRFEAGTLP----KSFDEMYACATNEFERSAIDDMLFGSV
Rv3829c|M.tuberculosis_H37Rv AWSQAPTRALGRFEAGTLP----KSFDEMYACATNEFERSAIDDMLFGSV
Mflv_1677|M.gilvum_PYR-GCK AWCQAPTRALGRFEAAQPP----KTLDEMFACATNEFERQAISDILFGSV
MMAR_2813|M.marinum_M GWSQGPARALGRFEVRTPP----RTLDEMYACATNQAERRAIHEMLFGSA
MUL_2934|M.ulcerans_Agy99 GWSQGPARALGRFEVRTPP----RTLDEMYACATNQAERRAIHEMLFGSA
MAV_2787|M.avium_104 GWSRGPAKALGRFDVRQPP----KTLDEMYACAVDDNERRAIHEMLFGSA
Mvan_0988|M.vanbaalenii_PYR-1 GWSHGPAQALGRFDVCTPP----KTIDEMYACAADEDQRRAIHDVLFGTA
MSMEG_0664|M.smegmatis_MC2_155 AWLEGIADVMGPLLTQVPPNIGSHRPADLLDLAKLAWGQRGITSRAVADI
MAB_0948c|M.abscessus_ATCC_199 ALCDSVTRPMWDSMLQPLR----------RRGAVRTGAWEQLIETPIGEV
TH_4571|M.thermoresistible__bu DRFDAVNDAVMGPLLRVPK-------------HPLTLARFGAPTVLPASA
. : .
Mb3859c|M.bovis_AF2122/97 TDVLDR----HFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFGL
Rv3829c|M.tuberculosis_H37Rv TDVLDR----HFPDREKHGALRGSMTVLAVNTLYRGPATPGSAAALAFGL
Mflv_1677|M.gilvum_PYR-GCK TDVLDR----YLPDREKHGALRGMLAFLAVNTTYRGPATPGSAAALAFGL
MMAR_2813|M.marinum_M MDVIDR----FLPDKEKHAVMRGMLAFLAVNSTYRGPFTPGSAACLAFAL
MUL_2934|M.ulcerans_Agy99 MDVIDR----FLPDKEKHAVMRGILAFLAVNSTYRGPFTPGSAACLAFAL
MAV_2787|M.avium_104 MDVIDR----YLPDRDKHAVMRGMLAFLAVNSTYRGPYTPGSAACLAFAL
Mvan_0988|M.vanbaalenii_PYR-1 MDAIDR----YLPDRHRHAVLRSMLAFLAVNSTYRGPYTPGSATCLAFAL
MSMEG_0664|M.smegmatis_MC2_155 TRLLTMSIADLLDDWFESPQIKGALAVNGVIGTWAGPYEPGTAYVMAHHS
MAB_0948c|M.abscessus_ATCC_199 IRAATP-----------DDVRRGVLLTDALIGTFASADDLSLQQNICFLY
TH_4571|M.thermoresistible__bu LARVFR-----------TPAARALWGGVAAHAFRPLHLPMTSAIGVGIIT
:. . :
Mb3859c|M.bovis_AF2122/97 G--VPEGDFVRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDN
Rv3829c|M.tuberculosis_H37Rv G--VPEGDFVRWKKLRGGIGALTTHLSQLLERTGGEVRLRSKVTEIVVDN
Mflv_1677|M.gilvum_PYR-GCK A--VPDENATLIKKFRGGMGAVTEHLLQMFTAAGGELRLRTKVDEILVD-
MMAR_2813|M.marinum_M A--VPDDSTAMMTKLRGGIGALTDHLRELFASAGGEIRFRSKVVEIVVD-
MUL_2934|M.ulcerans_Agy99 A--VPDDSTAMMTKLRGGIGALTDHLRERFASAGGEIRFRSKVVEIVVD-
MAV_2787|M.avium_104 A--VPDDSTAMMTKLRGGIGALTEHLRELFVSQGGEIRFRTKVEEILVT-
Mvan_0988|M.vanbaalenii_PYR-1 A--VPDDSTAMMTKLQGGIGALCDHLLDQYLRCGGAIRYRAKVDGITVD-
MSMEG_0664|M.smegmatis_MC2_155 IGDVGDGQLGSWGFPEGGMGAVSAAIACSARSFGAEIRTNARVSRLLVR-
MAB_0948c|M.abscessus_ATCC_199 H------QMNPWDVPIGGMGAVTGSLEASARRHGAELLSGAEVLSISPD-
TH_4571|M.thermoresistible__bu AG-----HRHGWAVAEGGSRAITDAMAARLRELGGTIETGVRVRDIADLP
** *: : *. : .* :
Mb3859c|M.bovis_AF2122/97 SRSSARVRGVRTAAGDTLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRY
Rv3829c|M.tuberculosis_H37Rv SRSSARVRGVRTAAGDTLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRY
Mflv_1677|M.gilvum_PYR-GCK ---GGRVTGVRLEDGATLSAPVVVSNLAPDLTVNQLVDGSAIPADIRERF
MMAR_2813|M.marinum_M ---RGAVSGVRLPDGSVISTPVVVSNLAPDVTLAKLVGPEHVGADLLARL
MUL_2934|M.ulcerans_Agy99 ---RGAVSGVRLPDGSVIGTPVVVSNLAPDVTLAKLVGPEHVPADLLARL
MAV_2787|M.avium_104 ---GRQVTGVRLRDESTVSAPIVVSNLSPDITLTELIAPEHVPAQLVSRV
Mvan_0988|M.vanbaalenii_PYR-1 ---GGRVTGVRLRDGSRIDAPAVISTLAPDLTLNTMVGAEHLPADLTARL
MSMEG_0664|M.smegmatis_MC2_155 ---NGRVEGAVLDNGDEIHAPVVVTTLHPKTAFLDHIPRTELPQDFVGDI
MAB_0948c|M.abscessus_ATCC_199 ----AEVRYRSDGGEHTVAGDRVLSGVSP-----------TVLAGLLGET
TH_4571|M.thermoresistible__bu --------------------PTTITVFDLAPEAVAEILGDRLPPRVARAY
.:: . : .
Mb3859c|M.bovis_AF2122/97 LRIDHRGSYLQMHFALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQ
Rv3829c|M.tuberculosis_H37Rv LRIDHRGSYLQMHFALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQ
Mflv_1677|M.gilvum_PYR-GCK ARIDHRGSYVQMHFALDGPPTFAEPYEVLNDPEYQSAIGIFTTPEELQQQ
MMAR_2813|M.marinum_M AGRDHRASFVQIHFALDALPEFAPPYELLNEPGMQQSVGIFGTPEEQQQQ
MUL_2934|M.ulcerans_Agy99 AGRDHRASFVQIHFALDALPEFAPPYELLNEPGMQQSVGIFGTPEEQQQQ
MAV_2787|M.avium_104 SGRDHRASFVQIHFALDGLPEFAPPHEFLNEEGMQQSVGIFGSPEEQQLH
Mvan_0988|M.vanbaalenii_PYR-1 TGRDHRASFVQIHFALDGLPEFAPPYDFLNEPGMQGSIGMFNSPEEQQRQ
MSMEG_0664|M.smegmatis_MC2_155 EHWKSRSGVVKINLALAELPNFTADPSSGIAEHHTGSVEMAPTMEFIEAA
MAB_0948c|M.abscessus_ATCC_199 PPAGQPGAQVKVNLLLRRLPRLRDE-NVTPEQAFGGTFHVNETYTQLEYA
TH_4571|M.thermoresistible__bu RAFRRGPGAFKVDFAVEGGVPWCNP-----DAHRAGTVHVGGTFEEIAAT
. .::.: : :. : :
Mb3859c|M.bovis_AF2122/97 WEDCRRGIVPADP-----TVVLQIPSLHDPSLAPAGKQAASAFAMWFPIE
Rv3829c|M.tuberculosis_H37Rv WEDCRRGIVPADP-----TVVLQIPSLHDPSLAPAGKQAASAFAMWFPIE
Mflv_1677|M.gilvum_PYR-GCK WEDSRRGVVPADP-----AIALQIPSANDPTLAPPGKHAVSAFSLWFPLS
MMAR_2813|M.marinum_M WETCRRGIVPENP-----SMGMQIPSVHDSGLAPPGKHAASAYAYAFPVE
MUL_2934|M.ulcerans_Agy99 WETCRRGIVPENP-----SMGMQIPSVHDSGLAPPGKHAASAYAYAFPVE
MAV_2787|M.avium_104 WENCRRGVVPDNP-----SMGMQIPSVHDPSMAPPGKHAASAFAYAFPVE
Mvan_0988|M.vanbaalenii_PYR-1 WEECRRGVIPDNP-----SMGMQIPSVHDPAMAPPGMHAASAFAYAFPVE
MSMEG_0664|M.smegmatis_MC2_155 FQDARNGKPALLP-----FSDGVIPTTLDTTLNPDGTHIMSLFTQWVPAE
MAB_0948c|M.abscessus_ATCC_199 YQQASHGRIPDPLPCEIYCHSLADPSILSPELRASGAHTLTVFGLHTPHG
TH_4571|M.thermoresistible__bu ERDVNAGRMPERP----------FVLVAQQYVADPGRSVGDIHPVWSYAH
. * . . : * .
Mb3859c|M.bovis_AF2122/97 GGSKYG-GYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMF
Rv3829c|M.tuberculosis_H37Rv GGSKYG-GYGRAKVEMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMF
Mflv_1677|M.gilvum_PYR-GCK --EEIS-GYGALKTEMGRRVIDKITRLATDFEKLILRHTTFTPKHMGTMF
MMAR_2813|M.marinum_M VGRDQ---HGHLKRLMAQRVIDKITRFAPNFKDIVIRYITFAPYHMQTMF
MUL_2934|M.ulcerans_Agy99 VDRDQ---HGHLKRIMARRVIDKITRFAPNFKDIVIRYITFAPYHMQTMF
MAV_2787|M.avium_104 VARDQ---HGRLKNAMAQRVIDKITRLAPNFKDIVIRHITFAPYHMNTMF
Mvan_0988|M.vanbaalenii_PYR-1 TPRDQ---HGRLKNVMAEKVIDKICRYAPNFRDVQIRHITFAPYHMDTMF
MSMEG_0664|M.smegmatis_MC2_155 WAAEP---HTEELDAYADRLIELYDQVAPGFKASITHRDIVGPYDMEHEY
MAB_0948c|M.abscessus_ATCC_199 LGASAEQLQQAVLASLSSVLAEPITDVVATDTHGRPCIETKTTIDLESAL
TH_4571|M.thermoresistible__bu VPHGYP-------GDATEAVVAQIERFAPGFRDRIVGYRTESAEGMARFN
: .. . :
Mb3859c|M.bovis_AF2122/97 G-APGGDYCHALLHSDQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGG
Rv3829c|M.tuberculosis_H37Rv G-APGGDYCHALLHSDQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGG
Mflv_1677|M.gilvum_PYR-GCK N-APGGDYCHGLIHPEQMGPNRPGPKGYVDQPIPIAG--LYLAGAGCHGG
MMAR_2813|M.marinum_M G-APSGDFCHGLLHPDLMGPNRPGPKGFLDFPIPIDG--LYLGGAGCHGG
MUL_2934|M.ulcerans_Agy99 G-APSGDFCHGLLHPDLMGPNRPGPGGFLDFPIPIDG--LYLGGAGCHGG
MAV_2787|M.avium_104 G-APSGDFCHGLLHPDLMGPNRPGPKGFVDMPIEIDG--LYLAGAGCHGG
Mvan_0988|M.vanbaalenii_PYR-1 A-APAGDFCHGLLHPDLMGPNRPGPKGFLDMPVPIDG--LYLGGAGCHGG
MSMEG_0664|M.smegmatis_MC2_155 G-LIGGNIFHGELSLEQLFHMRPAP-GYADYRTPIAG--LYNGSSATHAG
MAB_0948c|M.abscessus_ATCC_199 G-MTAGNIFHGGLQWPFAEDDDPLETAAQRWGVATNHDRILLCGSGSRRG
TH_4571|M.thermoresistible__bu ANFTGGDILTGAKDIRQLTFG--PRITLSPYATGAPG--YYICSAATPPG
.*: . .:. *
Mb3859c|M.bovis_AF2122/97 PGITFIPGYNAARQALADRRAANCCVLSGR----------
Rv3829c|M.tuberculosis_H37Rv PGITFIPGYNAARQALADRRAANCCVLSGR----------
Mflv_1677|M.gilvum_PYR-GCK PGITFIPGYNAAQQVLAEH---------------------
MMAR_2813|M.marinum_M PGITFIPGYNAAYQVLEDVATRQTSG--------------
MUL_2934|M.ulcerans_Agy99 PGITFIPGYNAAYQVLEDVATRQTSG--------------
MAV_2787|M.avium_104 PGITFTPGYNAAYQVLDDAS--------------------
Mvan_0988|M.vanbaalenii_PYR-1 PGITFIPGYNAAHQVLADRVSAASARTR------------
MSMEG_0664|M.smegmatis_MC2_155 GGVCGIPGWQAARAVLADKKRARRSEALRKRLPAALGGRS
MAB_0948c|M.abscessus_ATCC_199 GGVSGLGGYHAARAVLETH---------------------
TH_4571|M.thermoresistible__bu PGAHGMCGYHAAQTALRELAR-------------------
* *::** .*