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SDTNYDAIVVGAGHNGLTAAAILQRAGLRTVCLEANTYAGGMAATVELIDGFRYEIAGSVQFPMAAQLAK DLGLDTLPAVEPDVMSTNIGEHGEEPMIFYRDLVRLMTHLSDKHGLNAVTGMADLIGWSRGPAKALGRFD VRQPPKTLDEMYACAVDDNERRAIHEMLFGSAMDVIDRYLPDRDKHAVMRGMLAFLAVNSTYRGPYTPGS AACLAFALAVPDDSTAMMTKLRGGIGALTEHLRELFVSQGGEIRFRTKVEEILVTGRQVTGVRLRDESTV SAPIVVSNLSPDITLTELIAPEHVPAQLVSRVSGRDHRASFVQIHFALDGLPEFAPPHEFLNEEGMQQSV GIFGSPEEQQLHWENCRRGVVPDNPSMGMQIPSVHDPSMAPPGKHAASAFAYAFPVEVARDQHGRLKNAM AQRVIDKITRLAPNFKDIVIRHITFAPYHMNTMFGAPSGDFCHGLLHPDLMGPNRPGPKGFVDMPIEIDG LYLAGAGCHGGPGITFTPGYNAAYQVLDDAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2787 | - | - | 100% (522) | FAD dependent oxidoreductase, putative |
| M. avium 104 | MAV_0198 | - | 0.0 | 60.15% (522) | FAD dependent oxidoreductase, putative |
| M. avium 104 | MAV_5090 | - | 8e-25 | 24.86% (547) | putative dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3859c | - | 1e-177 | 57.36% (523) | putative dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1677 | - | 0.0 | 62.14% (515) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv3829c | - | 1e-177 | 57.55% (523) | dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0948c | - | 4e-08 | 43.42% (76) | hypothetical protein MAB_0948c |
| M. marinum M | MMAR_2813 | - | 0.0 | 80.92% (519) | dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0664 | - | 2e-44 | 29.00% (531) | FAD dependent oxidoreductase |
| M. thermoresistible (build 8) | TH_2567 | - | 1e-11 | 27.89% (337) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_2934 | - | 0.0 | 80.35% (519) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0988 | - | 0.0 | 76.02% (517) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3859c|M.bovis_AF2122/97 -----MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMASTV
Rv3829c|M.tuberculosis_H37Rv -----MTGYDAIVIGAGHNGLTAAVLLQRAGLRTACLDAKRYAGGMASTV
Mflv_1677|M.gilvum_PYR-GCK -----MTDFDAIVVGAGHNGLTAAALLQQAGLRTVCLDFKLYAGGMASTV
MMAR_2813|M.marinum_M -----MTDYDAIVVGAGHNGLTAAAVLQRAGLRTLCMEANTYTGGMAATV
MUL_2934|M.ulcerans_Agy99 -----MTDYDAIVVGAGHNGLTAAAVLQRAGLRTLCMEANTYAGGMAATV
MAV_2787|M.avium_104 ---MSDTNYDAIVVGAGHNGLTAAAILQRAGLRTVCLEANTYAGGMAATV
Mvan_0988|M.vanbaalenii_PYR-1 -----MSDYDAIIIGAGHNGLTAATVLQRAGLRTVLLEANTYAGGMAATV
MSMEG_0664|M.smegmatis_MC2_155 ----MSNNYDALVIGGGHNGLVSAAYLARAGARTLVLESRSSLGGAATTE
MAB_0948c|M.abscessus_ATCC_199 MGLSESDRYDTVIVGGGHNALTAAAYLARAGQRVMLLERLDVFGGAAISA
TH_2567|M.thermoresistible__bu --MTTEQEFDAIVIGAGAGGLFTAARLAHQGFRTVVVERLDKVGGRAS-T
:*::::*.* ..* :*. * : * *. :: ** *
Mb3859c|M.bovis_AF2122/97 ELFDG---YRFDIAGSVQFPTSSAVSSELGLDSLPTVDLEVMSVALRGVG
Rv3829c|M.tuberculosis_H37Rv ELFDG---YRFEIAGSVQFPTSSAVSSELGLDSLPTVDLEVMSVALRGVG
Mflv_1677|M.gilvum_PYR-GCK ELFDG---FRFEIAGSVQVPTSAVVSDALELGDLPTVDLDVMSVQLRGVG
MMAR_2813|M.marinum_M ELIDG---FHFEIAGSVQFPTASQISKELGLDTLPTVAPEVMSTNIGESS
MUL_2934|M.ulcerans_Agy99 ELIDG---FHFEIAGSVQFPTASQISKELGLDTLPTVAPEVMSTNIGESD
MAV_2787|M.avium_104 ELIDG---FRYEIAGSVQFPMAAQLAKDLGLDTLPAVEPDVMSTNIGEHG
Mvan_0988|M.vanbaalenii_PYR-1 ELIDG---FRYEIAGSVQFPTPAVVAKELGLDQLPTVDTEVMSVNLGDDG
MSMEG_0664|M.smegmatis_MC2_155 APWDDAPHLRVTRLSYVMSLMPPTIVRDLALERHGYKVHPMGPYYQAFPE
MAB_0948c|M.abscessus_ATCC_199 PAFEG-VEARLSRYSYLVSLMPRQIIDDLGLDVR-LARRKYASYTPDPMN
TH_2567|M.thermoresistible__bu DDIDG-----FKVNNGAIVIETGGITQQTCEEVGAPFDIREPKPPILYRI
:. . . :
Mb3859c|M.bovis_AF2122/97 DDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRALGRFEAGT
Rv3829c|M.tuberculosis_H37Rv DDPVVQFTDPTKMLTHLHRVHGADAVTGMAGLLAWSQAPTRALGRFEAGT
Mflv_1677|M.gilvum_PYR-GCK DDPLVYYTDPMKLLTHLNDVHGAEAVNGMAGLMAWCQAPTRALGRFEAAQ
MMAR_2813|M.marinum_M EEAMIFYRDPLQLISHLGEKHGSAAVTGMAELIGWSQGPARALGRFEVRT
MUL_2934|M.ulcerans_Agy99 EEAMIFYRDPLQLISHLGEKHGSAAVTGMAELIGWSQGPARALGRFEVRT
MAV_2787|M.avium_104 EEPMIFYRDLVRLMTHLSDKHGLNAVTGMADLIGWSRGPAKALGRFDVRQ
Mvan_0988|M.vanbaalenii_PYR-1 DEPMIFYRDPMQFMTHLAEKHGADAVAGMAGLLGWSHGPAQALGRFDVCT
MSMEG_0664|M.smegmatis_MC2_155 GGSLTIYEDDPARTYEQLSRFSKKDADAWPKWNAWLEGIADVMGPLLTQV
MAB_0948c|M.abscessus_ATCC_199 GGQRGFLAGP----------------NDFAEFGALCDSVTRPMWDSMLQP
TH_2567|M.thermoresistible__bu GG---------------------KNVDVTGGGWGFLLGKLTRQGAKLVKG
. .
Mb3859c|M.bovis_AF2122/97 LP----KSFDEMYACATNEFERSAIDDMLFGSVTDVLDR----HFPDREK
Rv3829c|M.tuberculosis_H37Rv LP----KSFDEMYACATNEFERSAIDDMLFGSVTDVLDR----HFPDREK
Mflv_1677|M.gilvum_PYR-GCK PP----KTLDEMFACATNEFERQAISDILFGSVTDVLDR----YLPDREK
MMAR_2813|M.marinum_M PP----RTLDEMYACATNQAERRAIHEMLFGSAMDVIDR----FLPDKEK
MUL_2934|M.ulcerans_Agy99 PP----RTLDEMYACATNQAERRAIHEMLFGSAMDVIDR----FLPDKEK
MAV_2787|M.avium_104 PP----KTLDEMYACAVDDNERRAIHEMLFGSAMDVIDR----YLPDRDK
Mvan_0988|M.vanbaalenii_PYR-1 PP----KTIDEMYACAADEDQRRAIHDVLFGTAMDAIDR----YLPDRHR
MSMEG_0664|M.smegmatis_MC2_155 PPNIGSHRPADLLDLAKLAWGQRGITSRAVADITRLLTMSIADLLDDWFE
MAB_0948c|M.abscessus_ATCC_199 LR----------RRGAVRTGAWEQLIETPIGEVIRAATP-----------
TH_2567|M.thermoresistible__bu IG-------------AARNDSGLPEDEISTAEWVAKYTK-----------
* . .
Mb3859c|M.bovis_AF2122/97 HGALRGSMTVLAVNTLYRGPATPGSAAALAFGLG--VPEGDFVRWKKLRG
Rv3829c|M.tuberculosis_H37Rv HGALRGSMTVLAVNTLYRGPATPGSAAALAFGLG--VPEGDFVRWKKLRG
Mflv_1677|M.gilvum_PYR-GCK HGALRGMLAFLAVNTTYRGPATPGSAAALAFGLA--VPDENATLIKKFRG
MMAR_2813|M.marinum_M HAVMRGMLAFLAVNSTYRGPFTPGSAACLAFALA--VPDDSTAMMTKLRG
MUL_2934|M.ulcerans_Agy99 HAVMRGILAFLAVNSTYRGPFTPGSAACLAFALA--VPDDSTAMMTKLRG
MAV_2787|M.avium_104 HAVMRGMLAFLAVNSTYRGPYTPGSAACLAFALA--VPDDSTAMMTKLRG
Mvan_0988|M.vanbaalenii_PYR-1 HAVLRSMLAFLAVNSTYRGPYTPGSATCLAFALA--VPDDSTAMMTKLQG
MSMEG_0664|M.smegmatis_MC2_155 SPQIKGALAVNGVIGTWAGPYEPGTAYVMAHHSIGDVGDGQLGSWGFPEG
MAB_0948c|M.abscessus_ATCC_199 DDVRRGVLLTDALIGTFASADDLSLQQNICFLYH------QMNPWDVPIG
TH_2567|M.thermoresistible__bu NEGVHGIFRNMCASVFAVGSEDLPARVFLTYFTR----KSAFKRFGFHPE
:. : .. : .
Mb3859c|M.bovis_AF2122/97 GIGALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGD-
Rv3829c|M.tuberculosis_H37Rv GIGALTTHLSQLLERTGGEVRLRSKVTEIVVDNSRSSARVRGVRTAAGD-
Mflv_1677|M.gilvum_PYR-GCK GMGAVTEHLLQMFTAAGGELRLRTKVDEILVD----GGRVTGVRLEDGA-
MMAR_2813|M.marinum_M GIGALTDHLRELFASAGGEIRFRSKVVEIVVD----RGAVSGVRLPDGS-
MUL_2934|M.ulcerans_Agy99 GIGALTDHLRERFASAGGEIRFRSKVVEIVVD----RGAVSGVRLPDGS-
MAV_2787|M.avium_104 GIGALTEHLRELFVSQGGEIRFRTKVEEILVT----GRQVTGVRLRDES-
Mvan_0988|M.vanbaalenii_PYR-1 GIGALCDHLLDQYLRCGGAIRYRAKVDGITVD----GGRVTGVRLRDGS-
MSMEG_0664|M.smegmatis_MC2_155 GMGAVSAAIACSARSFGAEIRTNARVSRLLVR----NGRVEGAVLDNGD-
MAB_0948c|M.abscessus_ATCC_199 GMGAVTGSLEASARRHGAELLSGAEVLSISPD-----AEVRYRSDGGEH-
TH_2567|M.thermoresistible__bu GTIGLWRGLAGAVERHGGQVWLSTPATKILTD----GTAVQGVVVERDGR
* .: : *. : : . : *
Mb3859c|M.bovis_AF2122/97 --TLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHF
Rv3829c|M.tuberculosis_H37Rv --TLTSPIVVSAIAPDVTINELIDPAVLPSEIRDRYLRIDHRGSYLQMHF
Mflv_1677|M.gilvum_PYR-GCK --TLSAPVVVSNLAPDLTVNQLVDGSAIPADIRERFARIDHRGSYVQMHF
MMAR_2813|M.marinum_M --VISTPVVVSNLAPDVTLAKLVGPEHVGADLLARLAGRDHRASFVQIHF
MUL_2934|M.ulcerans_Agy99 --VIGTPVVVSNLAPDVTLAKLVGPEHVPADLLARLAGRDHRASFVQIHF
MAV_2787|M.avium_104 --TVSAPIVVSNLSPDITLTELIAPEHVPAQLVSRVSGRDHRASFVQIHF
Mvan_0988|M.vanbaalenii_PYR-1 --RIDAPAVISTLAPDLTLNTMVGAEHLPADLTARLTGRDHRASFVQIHF
MSMEG_0664|M.smegmatis_MC2_155 --EIHAPVVVTTLHPKTAFLDHIPRTELPQDFVGDIEHWKSRSGVVKINL
MAB_0948c|M.abscessus_ATCC_199 --TVAGDRVLSGVSP-----------TVLAGLLGETPPAGQPGAQVKVNL
TH_2567|M.thermoresistible__bu QLTLTAPVVVSDVGPAATVT-LLGEENVPADYRKMVKKGDRPTSMISVNF
: *:: : * : . :.:::
Mb3859c|M.bovis_AF2122/97 ALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADP-
Rv3829c|M.tuberculosis_H37Rv ALAQPPAFAAPYQALNDPSMQASMGIFCTPEQVQQQWEDCRRGIVPADP-
Mflv_1677|M.gilvum_PYR-GCK ALDGPPTFAEPYEVLNDPEYQSAIGIFTTPEELQQQWEDSRRGVVPADP-
MMAR_2813|M.marinum_M ALDALPEFAPPYELLNEPGMQQSVGIFGTPEEQQQQWETCRRGIVPENP-
MUL_2934|M.ulcerans_Agy99 ALDALPEFAPPYELLNEPGMQQSVGIFGTPEEQQQQWETCRRGIVPENP-
MAV_2787|M.avium_104 ALDGLPEFAPPHEFLNEEGMQQSVGIFGSPEEQQLHWENCRRGVVPDNP-
Mvan_0988|M.vanbaalenii_PYR-1 ALDGLPEFAPPYDFLNEPGMQGSIGMFNSPEEQQRQWEECRRGVIPDNP-
MSMEG_0664|M.smegmatis_MC2_155 ALAELPNFTADPSSGIAEHHTGSVEMAPTMEFIEAAFQDARNGKPALLP-
MAB_0948c|M.abscessus_ATCC_199 LLRRLPRLRDE-NVTPEQAFGGTFHVNETYTQLEYAYQQASHGRIPDPLP
TH_2567|M.thermoresistible__bu ASR--------------ERLVDVPGMLSFAKSRRLAYIAN----------
: . :
Mb3859c|M.bovis_AF2122/97 ----TVVLQIPSLHDPSLAPAGKQAASAFAMWFPIEGGSKYG-GYGRAKV
Rv3829c|M.tuberculosis_H37Rv ----TVVLQIPSLHDPSLAPAGKQAASAFAMWFPIEGGSKYG-GYGRAKV
Mflv_1677|M.gilvum_PYR-GCK ----AIALQIPSANDPTLAPPGKHAVSAFSLWFPLS--EEIS-GYGALKT
MMAR_2813|M.marinum_M ----SMGMQIPSVHDSGLAPPGKHAASAYAYAFPVEVGRDQ---HGHLKR
MUL_2934|M.ulcerans_Agy99 ----SMGMQIPSVHDSGLAPPGKHAASAYAYAFPVEVDRDQ---HGHLKR
MAV_2787|M.avium_104 ----SMGMQIPSVHDPSMAPPGKHAASAFAYAFPVEVARDQ---HGRLKN
Mvan_0988|M.vanbaalenii_PYR-1 ----SMGMQIPSVHDPAMAPPGMHAASAFAYAFPVETPRDQ---HGRLKN
MSMEG_0664|M.smegmatis_MC2_155 ----FSDGVIPTTLDTTLNPDGTHIMSLFTQWVPAEWAAEP---HTEELD
MAB_0948c|M.abscessus_ATCC_199 CEIYCHSLADPSILSPELRASGAHTLTVFGLHTPHGLGASAEQLQQAVLA
TH_2567|M.thermoresistible__bu ----------FTDTCPEMAPEGWNLYVGTAVPKPSIGDFDQ----AAETE
: . : . * : * .
Mb3859c|M.bovis_AF2122/97 EMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHS
Rv3829c|M.tuberculosis_H37Rv EMGQNVIDKITRLAPNFKGSILRYTTFTPKHMGVMFGAPGGDYCHALLHS
Mflv_1677|M.gilvum_PYR-GCK EMGRRVIDKITRLATDFEKLILRHTTFTPKHMGTMFNAPGGDYCHGLIHP
MMAR_2813|M.marinum_M LMAQRVIDKITRFAPNFKDIVIRYITFAPYHMQTMFGAPSGDFCHGLLHP
MUL_2934|M.ulcerans_Agy99 IMARRVIDKITRFAPNFKDIVIRYITFAPYHMQTMFGAPSGDFCHGLLHP
MAV_2787|M.avium_104 AMAQRVIDKITRLAPNFKDIVIRHITFAPYHMNTMFGAPSGDFCHGLLHP
Mvan_0988|M.vanbaalenii_PYR-1 VMAEKVIDKICRYAPNFRDVQIRHITFAPYHMDTMFAAPAGDFCHGLLHP
MSMEG_0664|M.smegmatis_MC2_155 AYADRLIELYDQVAPGFKASITHRDIVGPYDMEHEYGLIGGNIFHGELSL
MAB_0948c|M.abscessus_ATCC_199 SLSSVLAEPITDVVATDTHGRPCIETKTTIDLESALGMTAGNIFHGGLQW
TH_2567|M.thermoresistible__bu LLLQDLRDNIDDFDN---RARILNIAITRDDWPPQRAVAGFDLPHDTPFA
: : . . : *
Mb3859c|M.bovis_AF2122/97 DQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGGPGITFIPGYNAARQA
Rv3829c|M.tuberculosis_H37Rv DQIGPNRPGPKGFIGQPIPIAG--LYLGSAGCHGGPGITFIPGYNAARQA
Mflv_1677|M.gilvum_PYR-GCK EQMGPNRPGPKGYVDQPIPIAG--LYLAGAGCHGGPGITFIPGYNAAQQV
MMAR_2813|M.marinum_M DLMGPNRPGPKGFLDFPIPIDG--LYLGGAGCHGGPGITFIPGYNAAYQV
MUL_2934|M.ulcerans_Agy99 DLMGPNRPGPGGFLDFPIPIDG--LYLGGAGCHGGPGITFIPGYNAAYQV
MAV_2787|M.avium_104 DLMGPNRPGPKGFVDMPIEIDG--LYLAGAGCHGGPGITFTPGYNAAYQV
Mvan_0988|M.vanbaalenii_PYR-1 DLMGPNRPGPKGFLDMPVPIDG--LYLGGAGCHGGPGITFIPGYNAAHQV
MSMEG_0664|M.smegmatis_MC2_155 EQLFHMRPAP-GYADYRTPIAG--LYNGSSATHAGGGVCGIPGWQAARAV
MAB_0948c|M.abscessus_ATCC_199 PFAEDDDPLETAAQRWGVATNHDRILLCGSGSRRGGGVSGLGGYHAARAV
TH_2567|M.thermoresistible__bu NLWNVG--------------DG-----VKEYANGGTTACAETAKLVVDKI
. * . ..
Mb3859c|M.bovis_AF2122/97 LADRRAANCCVLSGR----------
Rv3829c|M.tuberculosis_H37Rv LADRRAANCCVLSGR----------
Mflv_1677|M.gilvum_PYR-GCK LAEH---------------------
MMAR_2813|M.marinum_M LEDVATRQTSG--------------
MUL_2934|M.ulcerans_Agy99 LEDVATRQTSG--------------
MAV_2787|M.avium_104 LDDAS--------------------
Mvan_0988|M.vanbaalenii_PYR-1 LADRVSAASARTR------------
MSMEG_0664|M.smegmatis_MC2_155 LADKKRARRSEALRKRLPAALGGRS
MAB_0948c|M.abscessus_ATCC_199 LETH---------------------
TH_2567|M.thermoresistible__bu LASHRPAASR---------------
*