For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. marinum M MMAR_2459 (-)

annotation: PE-PGRS family protein
coordinates: 2971419 - 2973089
length: 556

MSFLLVQPEMVSAATESLTAIRSALGEVSAAVAGPTTAVVAAAGDEVSAAISQVFGAYGQEFQALNAQAA
AFQAEFEGLLSGGAAAYVSAEALNSSVFGPPMQELLKVVNAPTQMLLGRSLIADGANATVAGGDGRPGGI
LMGKGGDGAPGGPGQPGGNGGAAGLIGTGGAGGKEAPSMPGGLGGRGGLLWGDGGKGGDGGAPVYDAWGY
LLAEAGTGGAGGLPGMFGGLPGVAGAWGGEVPTALAAPMALSAAASSPAAVGGAYQTLFDNTWTNLQAIG
ATWNADPAPFLSQFIANQQTYANTVFTSLSNSVQDFGAGLVALPAAYQGAFQALMTGNVSGAVEILGKGY
LGLVFNGFDYTNVPVVTVQGALGDLLPITTIPGQISQNMTNVLQTVTDTSIMANISLLSPSFTTGFPLTL
ALDALGAPIVTGQAALQSATTFIDAVQAGDVAGAFGAIVDAPAVIANGFLNGEGTITLDLPTYLSPISGT
ESLTSAIPIGGILTPLQPVDSTIVFRVLPHTPPVTQHITLGGTEFGGLIPGLQSASAQLADAIKLS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_2459--100% (556)PE-PGRS family protein
M. marinum MMMAR_2460-2e-8836.24% (643) PE-PGRS family protein
M. marinum MMMAR_2458-1e-8635.54% (650) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1679cPE_PGRS303e-8142.52% (461) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-2e-1841.10% (146) triple helix repeat-containing collagen
M. tuberculosis H37RvRv1651cPE_PGRS303e-8142.52% (461) PE-PGRS family protein
M. leprae Br4923MLBr_01183-3e-0729.35% (92) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_0321c-5e-1236.84% (152) hypothetical protein MAB_0321c
M. avium 104MAV_1346-4e-1328.25% (269) PE family protein
M. smegmatis MC2 155MSMEG_0868-2e-2246.34% (123) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_4350-2e-1728.04% (271) PUTATIVE putative conserved hypothetical protein
M. ulcerans Agy99MUL_1639-0.098.74% (556) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_0928-5e-2142.41% (158) carboxymuconolactone decarboxylase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_2459|M.marinum_M               --------------------------------------------------
MUL_1639|M.ulcerans_Agy99           --------------------------------------------------
Mb1679c|M.bovis_AF2122/97           --------------------------------------------------
Rv1651c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------------------------------------------------
MUL_1639|M.ulcerans_Agy99           --------------------------------------------------
Mb1679c|M.bovis_AF2122/97           --------------------------------------------------
Rv1651c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------------------------------------------------
MUL_1639|M.ulcerans_Agy99           --------------------------------------------------
Mb1679c|M.bovis_AF2122/97           --------------------------------------------------
Rv1651c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------------------------------------------------
MUL_1639|M.ulcerans_Agy99           --------------------------------------------------
Mb1679c|M.bovis_AF2122/97           --------------------------------------------------
Rv1651c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------------------------------------------------
MUL_1639|M.ulcerans_Agy99           --------------------------------------------------
Mb1679c|M.bovis_AF2122/97           --------------------------------------------------
Rv1651c|M.tuberculosis_H37Rv        --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       -----------------MSGTQSAESDDDADDSEGDASADDAEDAEEFVG
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------MS-FLLVQPEMVSAATESLTAIRSALGEVSAAVAGPTTAVVA
MUL_1639|M.ulcerans_Agy99           --------MS-FLLVQPEMVSAATESLTAIRSALGEVSAAVAGPTTAVVA
Mb1679c|M.bovis_AF2122/97           --------MS-FLLVEPDLVTAAAANLAGIRSALSEAAAAASTPTTALAS
Rv1651c|M.tuberculosis_H37Rv        --------MS-FLLVEPDLVTAAAANLAGIRSALSEAAAAASTPTTALAS
MLBr_01183|M.leprae_Br4923          --------MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTEIAP
MAV_1346|M.avium_104                --------MS-FVTTRPEALLAVASMLEGLGSSMDAQNAAAAAPTTSIAP
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       DSGNGGSDDDAADDSEKDVDSSTDDGVGDFEGVVLDDAESEADSQLSVPQ
TH_4350|M.thermoresistible__bu      ----MLASIRPYATAGVALVGAGVIAVTPVAPPPADIQVSRQAVALSAIS
                                                                                      

MMAR_2459|M.marinum_M               AAGDEVSAAISQVFGAYGQEFQALNAQAAAFQAEFEGLLSGGAAAYVSAE
MUL_1639|M.ulcerans_Agy99           AAGDEVSAAISQVFGAYGQEFQALNAQAAAFQAEFEGLLSGGAAAYVSAE
Mb1679c|M.bovis_AF2122/97           AGADEVSAAVSRLFGAYGQQFQALNARAATFHAEFVSLLNGGAAAYTGAE
Rv1651c|M.tuberculosis_H37Rv        AGADEVSAAVSRLFGAYGQQFQALNARAATFHAEFVSLLNGGAAAYTGAE
MLBr_01183|M.leprae_Br4923          PAADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSAYAGTE
MAV_1346|M.avium_104                AAADEVSALQAAQFSAYGTWYQQVSAQAKAIHQTLVQNLDTNADSYGATE
Mflv_5091|M.gilvum_PYR-GCK          GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155      LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       PASTESTEQSADVANDADGNADPIADAGPEAVTAPVALSGASAPAIPDGP
TH_4350|M.thermoresistible__bu      NPGDPVVAYGELIANTIG-SLQGLGGQFAADPAPVLVKILQNQIANGQLI
                                                                                      

MMAR_2459|M.marinum_M               ALNSSVFGPPMQELLKVVNAPTQMLLGRSLIADGAN-----ATVAGGDGR
MUL_1639|M.ulcerans_Agy99           ALNSSVFGPPMQELLKVVNAPTQMLLGRSLIADGAN-----ATAAGGDGR
Mb1679c|M.bovis_AF2122/97           AASVS----SMQALLDAVNAPTQTLLGRPLIGNGADGVAGTGSNAGGNGG
Rv1651c|M.tuberculosis_H37Rv        AASVS----SMQALLDAVNAPTQTLLGRPLIGNGADGVAGTGSNAGGNGG
MLBr_01183|M.leprae_Br4923          TAN-----------------------------------------------
MAV_1346|M.avium_104                AANRV-----------NTSAAALQGLAPNVIPNAAP--------------
Mflv_5091|M.gilvum_PYR-GCK          VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
MSMEG_0868|M.smegmatis_MC2_155      GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       APVEPMGPLINSLWWAVPKSGGRSTNDASLTLAGTGIYPSVTSLFAFGGR
TH_4350|M.thermoresistible__bu      GSALDEALGFLLQGVEALPGALEEAFALLTQGDLKG--------------
                                                                                      

MMAR_2459|M.marinum_M               PGGILMGKGGDGAPGGP-GQPGGNGGAAGLIGTGGAGGKE---APSMPGG
MUL_1639|M.ulcerans_Agy99           PGGILMGKGGDGAPGGP-GQPGGNGGAAGLIGTGGAGGKG---APSMPGG
Mb1679c|M.bovis_AF2122/97           PGGILYGNGGNGGAGGPDGGAGGNGGAAGLIGNGGAGGAGGVGGAGGAGG
Rv1651c|M.tuberculosis_H37Rv        PGGILYGNGGNG-------GAGGNGGAAGLIGNGGAGGAGGAGGAGGAGG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          VG--SAGAAGEAGETGTWGNAGLPGKAGDAGGAG----AVGAAG---AAG
MSMEG_0868|M.smegmatis_MC2_155      VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       CGLICDGADGTEQNPNGVGGGWLFGDGGDGWSSTLAGIAGGKGGAAGLLW
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               LGGRGGLLWGDG--------------------------------------
MUL_1639|M.ulcerans_Agy99           LGGRGGLLWGDG--------------------------------------
Mb1679c|M.bovis_AF2122/97           AGGTGGLLYGNGGAGGNGGSAAAAGGAGGNALLFGNGGNGGSGASGGAAG
Rv1651c|M.tuberculosis_H37Rv        AGGTGGLLYGNGGAGGNGGSAAAAGGAGGNALLFGNGGNGGSGASGGAAG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          TVGTAGATGGTG----TGANGGAGGVG-----GVGGTGAAGAAGGAG---
MSMEG_0868|M.smegmatis_MC2_155      AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       GSGGDGGAGGAGAAGGTGGNAGLLWGNG----------------------
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------------------------GKGGDGGAPVYDAWGY--------
MUL_1639|M.ulcerans_Agy99           --------------------------GKGGDGGAPVYDAWGY--------
Mb1679c|M.bovis_AF2122/97           HAGTIFGNGGNAGAGSGLAGADGGLFGNGGDGGSSTSKAGGAGGNALFGN
Rv1651c|M.tuberculosis_H37Rv        HAGTIFGNGGNAGAGSGLAGADGGLFGNGGDGGSSTSKAGGAGGNALFGN
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ---GLGETGTTG--------------GAGGVGGQGTAGGTGGVGGIG---
MSMEG_0868|M.smegmatis_MC2_155      TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------GHGGAGGAGVNGAVGTSGVNN---
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               ------------------LLAEAGTGGAGGLPGMFG-----GLPGVAGAW
MUL_1639|M.ulcerans_Agy99           ------------------LLAEAGTGGAGGLPGIFG-----GLPGVAGAW
Mb1679c|M.bovis_AF2122/97           GGDGGSSTVAAGGAGGNTLVGNGGAGGAGGTSGLTGSGVAGGAGGSVGLW
Rv1651c|M.tuberculosis_H37Rv        GGDGGSSTVAAGGAGGNTLVGNGGAGGAGGTSGLTGSGVAGGAGGSVGLW
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------GAGSTGAVGG-----------VGGKGIQGG
MSMEG_0868|M.smegmatis_MC2_155      SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA
MAB_0321c|M.abscessus_ATCC_199      ------------------------------------------------MA
Mvan_0928|M.vanbaalenii_PYR-1       -----------------GRGGDGTAGGSGGAGGNAGLLSGRGGDGGVGGA
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               G-------------------------------------------------
MUL_1639|M.ulcerans_Agy99           G-------------------------------------------------
Mb1679c|M.bovis_AF2122/97           GSGGAGGDGGAATSLLGVGMNAGAGGAGGNAGLLYGNGGAGGAGGNGGDT
Rv1651c|M.tuberculosis_H37Rv        GSGGAGGDGGAATSLLGVGMNAGAGGAGGNAGLLYGNGGAGGAGGNGGDT
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          QGLQGGKGGDGGAGGKGGDADSMGS-------------------------
MSMEG_0868|M.smegmatis_MC2_155      KAGHGGKASDGGKGGNGGDALVMAAGATGVAT------------------
MAB_0321c|M.abscessus_ATCC_199      NIISNGPDGD----------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       GGKGGAGAHG----------------------------------------
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               ---------------------------------GEVPTALAAPMALSAAA
MUL_1639|M.ulcerans_Agy99           ---------------------------------GEVPTALAAPMALSAAA
Mb1679c|M.bovis_AF2122/97           TVPLFDSGVGGAGGAGGNASLFGNGGTGGVGGKGGTSSDLASATSGAGGA
Rv1651c|M.tuberculosis_H37Rv        TVPLFDSGVGGAGGAGGNASLFGNGGTGGVGGKGGTSSDLASATSGAGGA
MLBr_01183|M.leprae_Br4923          ------------------------------------------HDSL----
MAV_1346|M.avium_104                ----------------------------------AADPPPAGTTSLGTSI
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------AGATGGKGGN
MSMEG_0868|M.smegmatis_MC2_155      -----------------------------GNTAIGGNGGAASANGAVGGN
MAB_0321c|M.abscessus_ATCC_199      ----------------------------------------AGATGAQGSQ
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------------SDAVAAEEDGGPGGSGGA
TH_4350|M.thermoresistible__bu      ----------------------------------AVDAFMMGIIPAALGM
                                                                                      

MMAR_2459|M.marinum_M               SSPAAVG-------------------------------------------
MUL_1639|M.ulcerans_Agy99           SSPAAVG-------------------------------------------
Mb1679c|M.bovis_AF2122/97           GGAGGVGGLLYGNGGNGGAGGIGGAAINILANAGAGGAGGAAGSSFIGNG
Rv1651c|M.tuberculosis_H37Rv        GGAGGVGGLLYGNGGNGGAGGIGGAAINILANAGAGGAGGAAGSSFIGNG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                GWAQNVG-------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGNGGRGGLFG---------------KGGNAGNG----------------
MSMEG_0868|M.smegmatis_MC2_155      GGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN-----
MAB_0321c|M.abscessus_ATCC_199      G-------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       GGNAGAGGVGGR--------------------------------------
TH_4350|M.thermoresistible__bu      IVPLVAGSMIITN-------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------------------------------------------------
MUL_1639|M.ulcerans_Agy99           --------------------------------------------------
Mb1679c|M.bovis_AF2122/97           GNGGAGGAGGAAALFSSGVGGAGGSGGTALLLGSGGAGGNGGTGGANSGS
Rv1651c|M.tuberculosis_H37Rv        GNGGAGGAGGAAALFSSGVGGAGGSGGTALLLGSGGAGGNGGTGGANSGS
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          -------------------------------------------ADGGTGG
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------GPAGTTIDKGKAAGGNGG
MAB_0321c|M.abscessus_ATCC_199      -------------------------------------------ATGAAGA
Mvan_0928|M.vanbaalenii_PYR-1       --------------------------------------GALLFGRGGDGG
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------------------------------------------------
MUL_1639|M.ulcerans_Agy99           --------------------------------------------------
Mb1679c|M.bovis_AF2122/97           LFASPGGTGGAGGHGGAGGLIWGNGGAGGNGGNGGTTADGALEGGTGGIG
Rv1651c|M.tuberculosis_H37Rv        LFASPGGTGGAGGHGGAGGLIWGNGGAGGNGGNGGTTADGALEGGTGGIG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          AGGAGGTGG-TGGAGGTGG-----------------TGGTGGIGGAGSTG
MSMEG_0868|M.smegmatis_MC2_155      DGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTF
MAB_0321c|M.abscessus_ATCC_199      MANCNWIDDDCATRGGTGG-----------------TGGNGGPGGAG---
Mvan_0928|M.vanbaalenii_PYR-1       DGGSAGTGGAGGFGGTGGAIVVTLPG-----GKLSDSDGAGGAGGVGGAA
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------------------------------------------------
MUL_1639|M.ulcerans_Agy99           --------------------------------------------------
Mb1679c|M.bovis_AF2122/97           GTGGSAIAFGNGGQGGAGGTGGDHSGGNGIGGKGGASGNGGNAGQVFGDG
Rv1651c|M.tuberculosis_H37Rv        GTGGSAIAFGNGGQGGAGGTGGDHSGGNGIGGKGGASGNGGNAGQVFGDG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKGGTGGTGGAGGTG----
MSMEG_0868|M.smegmatis_MC2_155      VNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRGGDGALGGNGGTGGVGL
MAB_0321c|M.abscessus_ATCC_199      ---GPGGHGGVIDFEVETFMDGVT--LQAKGGRGGNGGHGGAGGTG----
Mvan_0928|M.vanbaalenii_PYR-1       GLGGDGGGGGLGGLLGQAGVNGDSGATAAAGNAGGVGGAGGLGGRLPIVD
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               --------------------------------------------------
MUL_1639|M.ulcerans_Agy99           --------------------------------------------------
Mb1679c|M.bovis_AF2122/97           GTGGTGGAGGAGSGTKAGGTGSDGGHGGNATLIGNGGDGGAGGAGGAGSP
Rv1651c|M.tuberculosis_H37Rv        GTGGTGGAGGAGSGTKAGGTGSDGGHGGNATLIGNGGDGGAGGAGGAGSP
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GDGGTGGTGGTGGTG---------GTGGTGGTGGAG-----------DGT
MSMEG_0868|M.smegmatis_MC2_155      GNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTAT
MAB_0321c|M.abscessus_ATCC_199      GTGGKGGDGDDCEFG---------------------------------RT
Mvan_0928|M.vanbaalenii_PYR-1       LNNASPAQATLAALIKKLGLPIQAATG-----------------IQLEDV
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               -------------------------------------------GAYQTLF
MUL_1639|M.ulcerans_Agy99           -------------------------------------------GAYQTLF
Mb1679c|M.bovis_AF2122/97           AGAPGNGGTGGTGGVLFGQSGSSGPPGAAALAFPSLSSSVPILGPYEDLI
Rv1651c|M.tuberculosis_H37Rv        AGAPGNGGTGGTGGVLFGQSGSSGPPGAAALAFPSLSSSVPILGPYEDLI
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGTGGTGG----TGGQGGQGGQGG-----------------TGGTGGQGG
MSMEG_0868|M.smegmatis_MC2_155      GGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNGG
MAB_0321c|M.abscessus_ATCC_199      GGNGGTGG-------RGGDGN--------------------FAGTGGNGG
Mvan_0928|M.vanbaalenii_PYR-1       DGRLVGPLNAYLYNTIIGKAIFDVGNTFSSASLSARVKEIVILSVGGQWG
TH_4350|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               DNTWTNLQAIGATWNADPAPFLSQFIANQQTYANTVFTSLSNSVQDFGAG
MUL_1639|M.ulcerans_Agy99           DNTWTNLQAIGATWNADPAPFLSQFIANQQTYANTVFTSLSNSVQDFGAG
Mb1679c|M.bovis_AF2122/97           ANTVANLASIGNTWLADPAPFLQQYLANQFGYGQLTLTALTDATRDFAIG
Rv1651c|M.tuberculosis_H37Rv        ANTVANLASIGNTWLADPAPFLQQYLANQFGYGQLTLTALTDATRDFAIG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                -------------------------------AAASDFITLGEGQFAPVPG
Mflv_5091|M.gilvum_PYR-GCK          -LGGGGGTG-----------------------GQGGTGGTGGQGGTGGTG
MSMEG_0868|M.smegmatis_MC2_155      TLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHGGNGGQG
MAB_0321c|M.abscessus_ATCC_199      -----------------------------------AILVKCQHDLSLGTH
Mvan_0928|M.vanbaalenii_PYR-1       SEYELYAHKLAAQLFGIPADAIAALANGQAPVGLSGNELLAAQFVQELVS
TH_4350|M.thermoresistible__bu      ----------------------TADNFARAVSAVLDVDAMLPTLLGFAGP
                                                                                      

MMAR_2459|M.marinum_M               LVALPAAYQGAFQALMTGNVSGAVEILGKGYLGLVFNGFDYTNVPVVTVQ
MUL_1639|M.ulcerans_Agy99           LVALPAAYQGAFQALMTGNVSGAVEILGKGYLGLVFNGFDYTNVPVVTVQ
Mb1679c|M.bovis_AF2122/97           LAGIPPSLQSALQALAAGDVSGAVTDVLGAVVKVFVSGVDASDLSNILLL
Rv1651c|M.tuberculosis_H37Rv        LAGIPPSLQSALQALAAGDVSGAVTDVLGAVVKVFVSGVDASDLSNILLL
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                AAGIPNFNPGLTAATTAGPPAPAAPAAAAGAPVLASMGRGPSIG------
Mflv_5091|M.gilvum_PYR-GCK          GTGGTG--------GTGGAGGDGGLGGLGGFGGSGGTGGQGGLGGPGGST
MSMEG_0868|M.smegmatis_MC2_155      TIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVVNTTANAANPGSAT
MAB_0321c|M.abscessus_ATCC_199      PMDVSA--------GTGGNGG------IGGGGGGG---------------
Mvan_0928|M.vanbaalenii_PYR-1       TRRVSDALFEAAEAAFGQTGVVDMVNLAGTYLGVSATLNAFKVRGPESFS
TH_4350|M.thermoresistible__bu      VLSAVDGFVTSGQAVLDGVLAGDPIAVLNAVASTPAVLIDAVLNGSGALL
                                                                                      

MMAR_2459|M.marinum_M               GALGDLLPITTIPGQISQNMTNVLQTVTDTSIMANISLLSPS--FTTGFP
MUL_1639|M.ulcerans_Agy99           GALGDLLPMTTIPGQISQNMTNVLQTVTDTSIMANISLLNPS--FTTGFP
Mb1679c|M.bovis_AF2122/97           GPVGDLFPILSIPGAMSQNFTNVVMTVTDTTIAFSIDTTNLTGVMTFGLP
Rv1651c|M.tuberculosis_H37Rv        GPVGDLFPILSIPGAMSQNFTNVVMTVTDTTIAFSIDTTNLTGVMTFGLP
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                ---GLSVPPSWAPGGVAPAAN-----------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGATGAAGASGGKGAQG
MSMEG_0868|M.smegmatis_MC2_155      GTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGNATGTATAGKGGEA
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       APVLPAAPSPVPASDEYGLGGRLPLIDLDTATPAQLDLAAKIKALAVPTQ
TH_4350|M.thermoresistible__bu      G--FLPLPGLLTPATAPIGGPIATLLGIRNAIADALQPVEQIAAASAAAP
                                                                                      

MMAR_2459|M.marinum_M               LTLALDALG-------APIVTGQAALQSATTFIDAVQAGDVAGAFG----
MUL_1639|M.ulcerans_Agy99           LTLALDALG-------APIVTGQAALQSATTFIDAVQAGDVAGAFG----
Mb1679c|M.bovis_AF2122/97           LAMTLNAVG-------SPITTAIAFAESTTAFVSAVQAGNLQAAAA----
Rv1651c|M.tuberculosis_H37Rv        LAMTLNAVG-------SPITTAIAFAESTTAFVSAVQAGNLQAAAA----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                -ATPAQLVG-------AGFTSAAPDTAPVTAVPGGVPSMATAGRGG----
Mflv_5091|M.gilvum_PYR-GCK          ATGAQGATG------AQGATG-ATGAAGKAGATGAAGAAGAAGSAG----
MSMEG_0868|M.smegmatis_MC2_155      SNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAATTAGATGGAGGFSN
MAB_0321c|M.abscessus_ATCC_199      --GSVGANG--------ATTGVFSSSSDCSGP-GPQPNPGSPGDPG----
Mvan_0928|M.vanbaalenii_PYR-1       QATGIELVSP-----DGRLIGPLNGYLYNPVIGQALFEVGNAFASS----
TH_4350|M.thermoresistible__bu      MAAKAEVKAEEEVDAVAAVTSVPGENFRTVNLTTELSTAVENPVAG----
                                                                                      

MMAR_2459|M.marinum_M               --------------AIVDAPAVIANGFLNGEGTITLDLPTYLSPISGTES
MUL_1639|M.ulcerans_Agy99           --------------AIVDAPAVIANGFLNGEETITLDLPTYLSPISGTES
Mb1679c|M.bovis_AF2122/97           --------------ALVGAPANVANGFLNGEARLPLALPTSAT---GGIP
Rv1651c|M.tuberculosis_H37Rv        --------------ALVGAPANVANGFLNGEARLPLALPTSAT---GGIP
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------YGLGAPRYGVKPTVMPKPAI----------------
Mflv_5091|M.gilvum_PYR-GCK          -------TTGAQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG------
MSMEG_0868|M.smegmatis_MC2_155      IAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANS
MAB_0321c|M.abscessus_ATCC_199      ----------------TSVAVSGAQGNPGQAQFLIVP-------------
Mvan_0928|M.vanbaalenii_PYR-1       -----------SLSSRIKEIVILSVGGQWGSGYEVYAHEKVARLVGIPEE
TH_4350|M.thermoresistible__bu      --------EPKKSAAVDGVPTTVATEEATTGATESLDPAAATEGDDGLED
                                                                                      

MMAR_2459|M.marinum_M               LTSAIPIG-----------------------------------------G
MUL_1639|M.ulcerans_Agy99           LTSAIPIG-----------------------------------------G
Mb1679c|M.bovis_AF2122/97           VTVEVPVG-----------------------------------------G
Rv1651c|M.tuberculosis_H37Rv        VTVEVPVG-----------------------------------------G
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --AAGEDGDAGSGGSG-INGGAGGAGG-----------------AGGEGG
MSMEG_0868|M.smegmatis_MC2_155      SAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGG
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       AIVSLASGHAPVGLSG-----------------------SELVAARFVQE
TH_4350|M.thermoresistible__bu      DSAKNANG------------------------------------------
                                                                                      

MMAR_2459|M.marinum_M               ILTPLQPVDSTIVFRVLPHTPPVTQHITLGGTEFGGLIPGLQS-ASAQLA
MUL_1639|M.ulcerans_Agy99           ILTPLQPVESTIVFRVLPHTPPVTQHITLGGTEFGGLIPGLQS-ASAQLA
Mb1679c|M.bovis_AF2122/97           ILAPLQPFQATAVIPVIG---PVT--VTLEGTPAGGIVPALVNYAPTQLA
Rv1651c|M.tuberculosis_H37Rv        ILAPLQPFQATAVIPVIG---PVT--VTLEGTPAGGIVPALVNYAPTQLA
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAV_1346|M.avium_104                --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          EGGDGGKGGAG--AEGGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSG
MSMEG_0868|M.smegmatis_MC2_155      NGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTP
MAB_0321c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_0928|M.vanbaalenii_PYR-1       LVSTYEVSSELYHSAEAAFGQAGLVDLVNLASTYLGASALLNVFEVPVPT
TH_4350|M.thermoresistible__bu      -GTDLSDGNKATPATTAGDTSADSGSNKAGQSTLRAGVKKATAKASAASS
                                                                                      

MMAR_2459|M.marinum_M               DAIKLS-----
MUL_1639|M.ulcerans_Agy99           DAIKLS-----
Mb1679c|M.bovis_AF2122/97           QAIAP------
Rv1651c|M.tuberculosis_H37Rv        QAIAP------
MLBr_01183|M.leprae_Br4923          -----------
MAV_1346|M.avium_104                -----------
Mflv_5091|M.gilvum_PYR-GCK          GSGGAAGDSDD
MSMEG_0868|M.smegmatis_MC2_155      GTAGTTGANNP
MAB_0321c|M.abscessus_ATCC_199      -----------
Mvan_0928|M.vanbaalenii_PYR-1       AALITTS----
TH_4350|M.thermoresistible__bu      TGGSDE-----