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TATDHAPAPDTVGTVTASGRWRALLLAAVAACAACGIIYELALLTLSTSLDGGGIVATSLIVAGYIAALG AGALLVKPLLAHAAIAFIAVEVLLGIIGGLSAAALYVAFAFIDGSTWVLALGTALIGGLVGAEVPLLMTL LQRGRLAEAADTGRTLANLNAADYLGALIGGLVWPFVLLPHLGMIRGAAATGIVNLVAAAVVSIFLLRQV VSTRQLAMALSSLLAALGLLVTLLVHARDIETTSRQELYADPIIAYRHTSYQEIVVTRRGNDLRLYLDGG LQFSTRDEYRYTESLVYPALGDGARSVLVLGGGDGLAARELLRLPRIERIVQVELDPAVIELARTTMREA NGGALDDPRVQVVIGDAMKWLRGTDSGQSRRFDAVIVDLPDPDTPALGRLYSAEFYALAAHALAPDGLMV VQAGSPFSTPTAFWRTVSTIKAAGYAVTPYHVHVPTFGDWGFALARRGGTAPIPAVPADAPSLRFLNQPV LNAATVFSSDVGPTMLEPSTLDNPRIVEDMRRGYR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2104 | speE | - | 100% (526) | spermidine synthase, SpeE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2632 | speE | 0.0 | 81.21% (511) | spermidine synthase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2601 | speE | 0.0 | 81.21% (511) | spermidine synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_3480 | - | 0.0 | 82.91% (509) | spermidine synthase |
| M. smegmatis MC2 155 | MSMEG_0085 | - | 4e-05 | 26.60% (203) | PTS system, Fru family protein, IIABC components |
| M. thermoresistible (build 8) | TH_0626 | speE | 0.0 | 78.16% (499) | PROBABLE SPERMIDINE SYNTHASE SPEE (PUTRESCINE |
| M. ulcerans Agy99 | MUL_1708 | speE | 0.0 | 98.67% (526) | spermidine synthase |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2104|M.marinum_M ------MTATDHAPAPDTVGTVTASGRWRALLLAAVAACAACGIIYELAL
MUL_1708|M.ulcerans_Agy99 ------MTATDHAPAPDTVGTVTASGRSRTLLLAAVAACAACGIIYEIAL
Mb2632|M.bovis_AF2122/97 ------MTSTRQAG-----EATEASVRWRAVLLAAVAACAACGLVYELAL
Rv2601|M.tuberculosis_H37Rv ------MTSTRQAG-----EATEASVRWRAVLLAAVAACAACGLVYELAL
TH_0626|M.thermoresistible__bu -----------------------------------VAACAACGLIYELAL
MAV_3480|M.avium_104 ------MSTVEVSAP---EAAPPSPGRWRALLLAAVAACAACGIIYELAL
MSMEG_0085|M.smegmatis_MC2_155 MTQPIITDDLVLLDVDAGSDKEAVIARLAGALGGAGRASDTAGLVGAAMA
*. :.*::
MMAR_2104|M.marinum_M LTLSTSLDGGGIVATSLIVAGYIAALGAGALLVKPLLAH------AAIAF
MUL_1708|M.ulcerans_Agy99 LTLSTSLDGGGIVATSLIVAGYIAALGAGALLVKPLLAH------AAIAF
Mb2632|M.bovis_AF2122/97 LTLAASLNGGGIVATSLIVAGYIAALGAGALLIKPLLAH------AAIAF
Rv2601|M.tuberculosis_H37Rv LTLAASLNGGGIVATSLIVAGYIAALGAGALLIKPLLAH------AAIAF
TH_0626|M.thermoresistible__bu LTLSASVHGGGIVATSLIVAGYVAALGAGALLVKPLLGH------AAITF
MAV_3480|M.avium_104 LTLSASLDGGGIVATSLIVAGYIAALGVGALLAKPLLAH------AALGF
MSMEG_0085|M.smegmatis_MC2_155 REAQSATGLPGGIAIPHCRSPYVDTATIGFARLDPKVDFGAPDGPADLAF
:: * :* . : *: : * .* : . * : *
MMAR_2104|M.marinum_M IAVEVLLG----IIGGLSAAALYVAFAFID---GSTWVLALGTALIGGLV
MUL_1708|M.ulcerans_Agy99 IAVEVLLG----MIGGLSAAALYVAFAFID---GSTWVLALGTALIGGLV
Mb2632|M.bovis_AF2122/97 IAVEAVLG----IIGGLSAAALYAAFAFLDELDGSTLVLAVGTALIGGLV
Rv2601|M.tuberculosis_H37Rv IAVEAVLG----IIGGLSAAALYAAFAFLDELDGSTLVLAVGTALIGGLV
TH_0626|M.thermoresistible__bu IAVETLLG----IIGGLSAAALYLAFVFIG---GSLWVLVVGTALIGCLV
MAV_3480|M.avium_104 IAVEALLG----VVGGLSAAALYVVFAFLDGSVGSTWVLAVSTALIGGLV
MSMEG_0085|M.smegmatis_MC2_155 LIAAPESGGSEHMKLLSSLARALVRKDFVESLRSASSTQEVVELVNSAVK
: . * : * * *: .: . : : . :
MMAR_2104|M.marinum_M GAEVPLLMTLLQRGRLAEAADTGRTLANLN------AADYLGALIGGLVW
MUL_1708|M.ulcerans_Agy99 GAEVPLLMTLLQRGRLAEAADTGRTLANLN------AADYLGALIGGLVW
Mb2632|M.bovis_AF2122/97 GAEVPLLMTLLQRGRVAGAADAGRTLANLN------AADYLGALVGGLAW
Rv2601|M.tuberculosis_H37Rv GAEVPLLMTLLQRGRVAGAADAGRTLANLN------AADYLGALVGGLAW
TH_0626|M.thermoresistible__bu GAEVPLLMTLLQRGRVAGAADTGRVLANLN------AADYLGALIGGLSW
MAV_3480|M.avium_104 GAEVPLLMTLLQRGRTAGPADAGRTLANLN------AADYLGALLGGLVW
MSMEG_0085|M.smegmatis_MC2_155 PAAAPPASAPKPAAEPKPAADKSVSIVAVTSCPTGIAHTYMAADALKAAA
* .* : .. .** . :. :. * *:.*
MMAR_2104|M.marinum_M PFVLLPHLGMIRGAAATG--IVNLVAAAVVSIFLLRQVVSTRQLAMALSS
MUL_1708|M.ulcerans_Agy99 PFVLLPHLGMIRGAAATG--IVNLVAAAVVSIFLLRQVVSTRQLAMALCS
Mb2632|M.bovis_AF2122/97 PFLLLPQLGMIRGAAVTG--IVNLAAAGVVSIFLLRHVVSGRQLVTALCA
Rv2601|M.tuberculosis_H37Rv PFLLLPQLGMIRGAAVTG--IVNLAAAGVVSIFLLRHVVSGRQLVTALCA
TH_0626|M.thermoresistible__bu PFLLLPQLGMIRGAAVTG--VINLTAAAVVAVFLLRHIISGRQLAAALGV
MAV_3480|M.avium_104 PFLLLPQLGMIRGAAATG--MINLAAAAVVAIFLLRQVVSARQLALALCA
MSMEG_0085|M.smegmatis_MC2_155 EKAGVACTVETQGSAGSTPLSAETIAAADAVIFATDVGVKDRQRFAGKPV
:. :*:* : : **. . :* :. ** .
MMAR_2104|M.marinum_M LLAALG--------LLVTLLVHARDIETTSRQELYADPIIAYR-----HT
MUL_1708|M.ulcerans_Agy99 LLAALG--------LLVTLLVHARDIETTSRQELYADPIIAYR-----HT
Mb2632|M.bovis_AF2122/97 LAAALG--------LIATLLVHSHDIETTGRQQLYADPIIAYR-----HS
Rv2601|M.tuberculosis_H37Rv LAAALG--------LIATLLVHSHDIETTGRQQLYADPIIAYR-----HS
TH_0626|M.thermoresistible__bu LAAALT--------LLTTLLVRADGIETTSRQRLYADPIIAYE-----RS
MAV_3480|M.avium_104 LAAALA--------LLATLLLRSADVETTSRQRLYADPIIAYR-----HT
MSMEG_0085|M.smegmatis_MC2_155 IASGVKRAINEPDKMVAEAISAASDPGAPWVAGQAAESASAPAGDVGWGT
: :.: ::. : : . :. *:. * :
MMAR_2104|M.marinum_M SYQEIVVTRRGNDLRLYLDGGLQFST----------RDEYRYTESLVYPA
MUL_1708|M.ulcerans_Agy99 SYQEIVVTRRGNDLRLYLDGGLQFST----------RDEYRYTESLVYPA
Mb2632|M.bovis_AF2122/97 AYQEIVVTRRGDDLRLYLDGGLQFCT----------RDEYRYTESLVYPA
Rv2601|M.tuberculosis_H37Rv AYQEIVVTRRGDDLRLYLDGGLQFCT----------RDEYRYTESLVYPA
TH_0626|M.thermoresistible__bu PYQEIVITRRGADLRLYLDGGLQFST----------RDEHRYTESLVHPA
MAV_3480|M.avium_104 PYQEIVVTRRGDDTRLYLDGGLQFST----------RDEYRYTESLVYPA
MSMEG_0085|M.smegmatis_MC2_155 RIRQILLTGVSYMIPFVAAGGLLIALGFLLAGYEIGNTPDGETQSLGNII
::*::* . : *** :. . *:**
MMAR_2104|M.marinum_M LGDGARSVLVLGGGDGLAARELLRLPRIERIVQVELDPAVIELARTTMRE
MUL_1708|M.ulcerans_Agy99 LGDGARSVLVLGGGDGLAARELLRLPRIERIVQVELDPAVIELARTTMRE
Mb2632|M.bovis_AF2122/97 VSDGARSVLVLGGGDGLAARELLRQPGIEQIVQVELDPAVIELARTTLRD
Rv2601|M.tuberculosis_H37Rv VSDGARSVLVLGGGDGLAARELLRQPGIEQIVQVELDPAVIELARTTLRD
TH_0626|M.thermoresistible__bu LDESTRSVLILGGGDGLAARELLRYPGIDSIVQVELDPAVIELARTTLRP
MAV_3480|M.avium_104 LGNGARSVLVLGGGDGLAARELLRQPGISRIVQVELDPAVIEIARTTLRA
MSMEG_0085|M.smegmatis_MC2_155 ATHNSLTNLPSGGVAQYLGAVLFTLGGLAFSFLVPALAGYIAFAIADRPG
..: : * ** . *: : . * .. * :* :
MMAR_2104|M.marinum_M AN-------------GGALDDPRVQVVIGDAMKWLRG--TDSGQSRRFDA
MUL_1708|M.ulcerans_Agy99 AN-------------GGALDDPRVQVVIGDAMKWLRG--TDSGQSRRFDA
Mb2632|M.bovis_AF2122/97 VN-------------AGSLDNPRVHVVIDDAMSWLRG---AAVPPAGFDA
Rv2601|M.tuberculosis_H37Rv VN-------------AGSLDNPRVHVVIDDAMSWLRG---AAVPPAGFDA
TH_0626|M.thermoresistible__bu VN-------------GGALDDPRVTVVTDDAMRWLREPPPDLRPPGGFDA
MAV_3480|M.avium_104 AN-------------GGSLDNPRVRVLTGDAMAWLRG-----PNPDRFDA
MSMEG_0085|M.smegmatis_MC2_155 IAPGFTAGAVAVFVGGGFIGGIVGGLIAGFAALWISRIGVPQWARGLMPV
.* :.. :: . * *: : .
MMAR_2104|M.marinum_M VIVDLPDPDTP------ALGRLYSAEFYALAAHALAPDGLMVVQAGSPFS
MUL_1708|M.ulcerans_Agy99 VIVDLPDPDTP------ALGRLYSAEFYALAAHALAPDGLMVVQAGSPFS
Mb2632|M.bovis_AF2122/97 VIVDLRDPDTP------VLGRLYSTEFYALAARALAPGGLMVVQAGSPYS
Rv2601|M.tuberculosis_H37Rv VIVDLRDPDTP------VLGRLYSTEFYALAARALAPGGLMVVQAGSPYS
TH_0626|M.thermoresistible__bu VIVDLPDPDTP------VLGRLYSTEFYALVTRALAPGGRMVVQAGSPYS
MAV_3480|M.avium_104 VIVDLPDPDTP------VLGRLYSTEFYTLAARALAPGGLLVVQAGSPFS
MSMEG_0085|M.smegmatis_MC2_155 VVIPLFASMVVGLLMFLLLGRPLAALTSGLTNWLGGLSGGSAIALGVILG
*:: * . . *** :: *. . .* .: * .
MMAR_2104|M.marinum_M TPTAFWRTVSTIKAAGYAVTPYHVHVPTFGDWGFALARRGG--TAPIPAV
MUL_1708|M.ulcerans_Agy99 TPTAFWRTVSTIKAAGYAVTPYHVHVPTFGDWGFALARRGG--TAPIPAV
Mb2632|M.bovis_AF2122/97 TPTAFWRIISTIRSAGYAVTPYHVHVPTFGDWGFALARLTD--IAPTPAV
Rv2601|M.tuberculosis_H37Rv TPTAFWRIISTIRSAGYAVTPYHVHVPTFGDWGFALARLTD--IAPTPAV
TH_0626|M.thermoresistible__bu TPTAFWRTVSTIASAGYAVTPYHVHVPTFGDWGFVLATRGT--EPPRPTV
MAV_3480|M.avium_104 TPTAYWRTVSTIRAAGYAVTPYHVHVPTFGDWGFVLAQRGD--TPPAPKV
MSMEG_0085|M.smegmatis_MC2_155 -LMMCFDLGGPVNKAAYAFATASLVNPTQANLQIMAAVMAAGMVPPLAMA
: ..: *.**.:. : ** .: : * .* . .
MMAR_2104|M.marinum_M PADAPSLRFLNQP---------VLNAATVFSSDVGPTMLEPSTLDNPRIV
MUL_1708|M.ulcerans_Agy99 PADAPSLRFLNQP---------VLNAATVFSSDVGPTMLEPSTLDNPRIV
Mb2632|M.bovis_AF2122/97 PSTAPALRFLDQQ---------VLEAATVFSGDIRPRTLDPSTLDNPHIV
Rv2601|M.tuberculosis_H37Rv PSTAPALRFLDQQ---------VLEAATVFSGDIRPRTLDPSTLDNPHIV
TH_0626|M.thermoresistible__bu PANAPELRFLDQR---------VLDAATVFGKDRPPLTLEPSTLDRPRVV
MAV_3480|M.avium_104 PPDAPPLRFLDQR---------VLQAAVVFSGDVGPRPLEPSTLDNPRIV
MSMEG_0085|M.smegmatis_MC2_155 LATVIRPRLFSEPERENGRAAWLLGASFITEGAIPFAAADPLRVIPSMMV
. . *::.: :* *: : :* : . :*
MMAR_2104|M.marinum_M EDMRRGYR------------------------------------------
MUL_1708|M.ulcerans_Agy99 EDMRPGLRRC----------------------------------------
Mb2632|M.bovis_AF2122/97 EDMRHGWD------------------------------------------
Rv2601|M.tuberculosis_H37Rv EDMRHGWD------------------------------------------
TH_0626|M.thermoresistible__bu DDIRRGWQ------------------------------------------
MAV_3480|M.avium_104 GDMRHGYD------------------------------------------
MSMEG_0085|M.smegmatis_MC2_155 GGAVTGATVMAAAVTLRAPHGGIFVFFAIGNLLWFVIAVALGTVVSALTV
. *
MMAR_2104|M.marinum_M ----------------------
MUL_1708|M.ulcerans_Agy99 ----------------------
Mb2632|M.bovis_AF2122/97 ----------------------
Rv2601|M.tuberculosis_H37Rv ----------------------
TH_0626|M.thermoresistible__bu ----------------------
MAV_3480|M.avium_104 ----------------------
MSMEG_0085|M.smegmatis_MC2_155 IAAKQFTKRPVTAPEAPALATT