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MSTVEVSAPEAAPPSPGRWRALLLAAVAACAACGIIYELALLTLSASLDGGGIVATSLIVAGYIAALGVG ALLAKPLLAHAALGFIAVEALLGVVGGLSAAALYVVFAFLDGSVGSTWVLAVSTALIGGLVGAEVPLLMT LLQRGRTAGPADAGRTLANLNAADYLGALLGGLVWPFLLLPQLGMIRGAAATGMINLAAAAVVAIFLLRQ VVSARQLALALCALAAALALLATLLLRSADVETTSRQRLYADPIIAYRHTPYQEIVVTRRGDDTRLYLDG GLQFSTRDEYRYTESLVYPALGNGARSVLVLGGGDGLAARELLRQPGISRIVQVELDPAVIEIARTTLRA ANGGSLDNPRVRVLTGDAMAWLRGPNPDRFDAVIVDLPDPDTPVLGRLYSTEFYTLAARALAPGGLLVVQ AGSPFSTPTAYWRTVSTIRAAGYAVTPYHVHVPTFGDWGFVLAQRGDTPPAPKVPPDAPPLRFLDQRVLQ AAVVFSGDVGPRPLEPSTLDNPRIVGDMRHGYD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3480 | - | - | 100% (523) | spermidine synthase |
| M. avium 104 | MAV_4987 | - | 9e-05 | 26.95% (141) | sugar transporter family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2632 | speE | 0.0 | 81.69% (508) | spermidine synthase |
| M. gilvum PYR-GCK | Mflv_0983 | - | 7e-05 | 28.24% (216) | hypothetical protein Mflv_0983 |
| M. tuberculosis H37Rv | Rv2601 | speE | 0.0 | 81.69% (508) | spermidine synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2104 | speE | 0.0 | 82.91% (509) | spermidine synthase, SpeE |
| M. smegmatis MC2 155 | MSMEG_3563 | - | 4e-05 | 27.89% (251) | drug transporter |
| M. thermoresistible (build 8) | TH_0626 | speE | 0.0 | 77.64% (501) | PROBABLE SPERMIDINE SYNTHASE SPEE (PUTRESCINE |
| M. ulcerans Agy99 | MUL_1708 | speE | 0.0 | 82.48% (508) | spermidine synthase |
| M. vanbaalenii PYR-1 | Mvan_3722 | - | 4e-05 | 23.02% (391) | hypothetical protein Mvan_3722 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2632|M.bovis_AF2122/97 -MTSTRQAG-----EATEASVRWRAVLLAAVAACAAC--GLVYELALLTL
Rv2601|M.tuberculosis_H37Rv -MTSTRQAG-----EATEASVRWRAVLLAAVAACAAC--GLVYELALLTL
MAV_3480|M.avium_104 -MSTVEVSAP---EAAPPSPGRWRALLLAAVAACAAC--GIIYELALLTL
MMAR_2104|M.marinum_M -MTATDHAPAPDTVGTVTASGRWRALLLAAVAACAAC--GIIYELALLTL
MUL_1708|M.ulcerans_Agy99 -MTATDHAPAPDTVGTVTASGRSRTLLLAAVAACAAC--GIIYEIALLTL
TH_0626|M.thermoresistible__bu ------------------------------VAACAAC--GLIYELALLTL
Mflv_0983|M.gilvum_PYR-GCK ---------------MMALTVGLAVFVGIALGLLGGG--GSILTVPLLAY
MSMEG_3563|M.smegmatis_MC2_155 MTSSPASAPPQPPELLLTPRRRNLVFLAVLFGMLLAALDQTIVATALPTV
Mvan_3722|M.vanbaalenii_PYR-1 -MTGTPPVPEDHPSSQPLPGVGAGTAAILVFTSSAAVLVVEITALRLLAP
. . : * :
Mb2632|M.bovis_AF2122/97 AASLNGG---GIVATSLIVAGYIAALGAGAL-------------------
Rv2601|M.tuberculosis_H37Rv AASLNGG---GIVATSLIVAGYIAALGAGAL-------------------
MAV_3480|M.avium_104 SASLDGG---GIVATSLIVAGYIAALGVGAL-------------------
MMAR_2104|M.marinum_M STSLDGG---GIVATSLIVAGYIAALGAGAL-------------------
MUL_1708|M.ulcerans_Agy99 STSLDGG---GIVATSLIVAGYIAALGAGAL-------------------
TH_0626|M.thermoresistible__bu SASVHGG---GIVATSLIVAGYVAALGAGAL-------------------
Mflv_0983|M.gilvum_PYR-GCK VAGMDAK---QAIATSLLVVGVTSAIGA----------------------
MSMEG_3563|M.smegmatis_MC2_155 VADLGGAGHQSWVVTSYLLASTIVTAVVGKVGDLFGRKVVFQAAVLFFLA
Mvan_3722|M.vanbaalenii_PYR-1 YLGLTLET--STLVIGIALAAIALGSWAGGR-------------------
.: :. . :.. .
Mb2632|M.bovis_AF2122/97 -LIKPLLAHAAIAFIAVEAVLGIIGGLSAAALYAAFAFLDEL------DG
Rv2601|M.tuberculosis_H37Rv -LIKPLLAHAAIAFIAVEAVLGIIGGLSAAALYAAFAFLDEL------DG
MAV_3480|M.avium_104 -LAKPLLAHAALGFIAVEALLGVVGGLSAAALYVVFAFLDGS------VG
MMAR_2104|M.marinum_M -LVKPLLAHAAIAFIAVEVLLGIIGGLSAAALYVAFAFID---------G
MUL_1708|M.ulcerans_Agy99 -LVKPLLAHAAIAFIAVEVLLGMIGGLSAAALYVAFAFID---------G
TH_0626|M.thermoresistible__bu -LVKPLLGHAAITFIAVETLLGIIGGLSAAALYLAFVFIG---------G
Mflv_0983|M.gilvum_PYR-GCK ------VSHARAGRVQWRTGL-IFGAAGMAGAYAG--------------G
MSMEG_3563|M.smegmatis_MC2_155 GSVLCGLSGSMTMLVAARALQGIGGGAMMVTATALIGEVIPLRDRGRYQG
Mvan_3722|M.vanbaalenii_PYR-1 ------LADRDDPRRWLGTSLGVSGVVVAFTPSAVRAAAEWAP------A
:. . : * .
Mb2632|M.bovis_AF2122/97 STLVLAVGTALIG-GLVG-------------------------AEVPLLM
Rv2601|M.tuberculosis_H37Rv STLVLAVGTALIG-GLVG-------------------------AEVPLLM
MAV_3480|M.avium_104 STWVLAVSTALIG-GLVG-------------------------AEVPLLM
MMAR_2104|M.marinum_M STWVLALGTALIG-GLVG-------------------------AEVPLLM
MUL_1708|M.ulcerans_Agy99 STWVLALGTALIG-GLVG-------------------------AEVPLLM
TH_0626|M.thermoresistible__bu SLWVLVVGTALIG-CLVG-------------------------AEVPLLM
Mflv_0983|M.gilvum_PYR-GCK LLARFIPGTVLLI-GFAL-------------------------MMIATAV
MSMEG_3563|M.smegmatis_MC2_155 ALGAVFGVTTVIG-PLLGGFFTDHMSWRWAFWINVPVGILVLVIAAGAIP
Mvan_3722|M.vanbaalenii_PYR-1 TLLIVATLTILAPG-----------------------------ALLSAVT
. * :
Mb2632|M.bovis_AF2122/97 TLLQRGRVAGAADAGRTLANLNAA-DYLGALVGGLAWPFLLLPQLGMIRG
Rv2601|M.tuberculosis_H37Rv TLLQRGRVAGAADAGRTLANLNAA-DYLGALVGGLAWPFLLLPQLGMIRG
MAV_3480|M.avium_104 TLLQRGRTAGPADAGRTLANLNAA-DYLGALLGGLVWPFLLLPQLGMIRG
MMAR_2104|M.marinum_M TLLQRGRLAEAADTGRTLANLNAA-DYLGALIGGLVWPFVLLPHLGMIRG
MUL_1708|M.ulcerans_Agy99 TLLQRGRLAEAADTGRTLANLNAA-DYLGALIGGLVWPFVLLPHLGMIRG
TH_0626|M.thermoresistible__bu TLLQRGRVAGAADTGRVLANLNAA-DYLGALIGGLSWPFLLLPQLGMIRG
Mflv_0983|M.gilvum_PYR-GCK AMLR-GRKNVQATEGSHRLPVPKI-LAEGLLVG---------LVTGLVG-
MSMEG_3563|M.smegmatis_MC2_155 ALVRSGRRPAIDYVGILFVGLGASGLTLATSWGGGEYAWTSPMIIGLFIG
Mvan_3722|M.vanbaalenii_PYR-1 PMVTKLRLIKLAQTGTIVGQLSGV-GTMGAIAGTVLTGFVFVSRMPVSVI
.:: * * : . * :
Mb2632|M.bovis_AF2122/97 AAVTGIVNLAAAGVVSIFLLRHVVSGR--------QLVTALCALAAALGL
Rv2601|M.tuberculosis_H37Rv AAVTGIVNLAAAGVVSIFLLRHVVSGR--------QLVTALCALAAALGL
MAV_3480|M.avium_104 AAATGMINLAAAAVVAIFLLRQVVSAR--------QLALALCALAAALAL
MMAR_2104|M.marinum_M AAATGIVNLVAAAVVSIFLLRQVVSTR--------QLAMALSSLLAALGL
MUL_1708|M.ulcerans_Agy99 AAATGIVNLVAAAVVSIFLLRQVVSTR--------QLAMALCSLLAALGL
TH_0626|M.thermoresistible__bu AAVTGVINLTAAAVVAVFLLRHIISGR--------QLAAALGVLAAALTL
Mflv_0983|M.gilvum_PYR-GCK -AGGGFLVVPALALLGGLPMPVAVGTS--------LIVIAMKSFAGLGGY
MSMEG_3563|M.smegmatis_MC2_155 SITALVLFVRAETRAAEPILPMRLFRSPVFTVCCVLSFIVGFAMLGALTF
Mvan_3722|M.vanbaalenii_PYR-1 LIGLGSILVLGGIVVESRMRRRNTLSA--------IVITLATVGAGLAGY
: : . .
Mb2632|M.bovis_AF2122/97 IATLLVHSHDIETTGRQQLYADPIIAYRHSAYQEIVVTRRGDDLRLYLDG
Rv2601|M.tuberculosis_H37Rv IATLLVHSHDIETTGRQQLYADPIIAYRHSAYQEIVVTRRGDDLRLYLDG
MAV_3480|M.avium_104 LATLLLRSADVETTSRQRLYADPIIAYRHTPYQEIVVTRRGDDTRLYLDG
MMAR_2104|M.marinum_M LVTLLVHARDIETTSRQELYADPIIAYRHTSYQEIVVTRRGNDLRLYLDG
MUL_1708|M.ulcerans_Agy99 LVTLLVHARDIETTSRQELYADPIIAYRHTSYQEIVVTRRGNDLRLYLDG
TH_0626|M.thermoresistible__bu LTTLLVRADGIETTSRQRLYADPIIAYERSPYQEIVITRRGADLRLYLDG
Mflv_0983|M.gilvum_PYR-GCK LSS-----------------------------------------------
MSMEG_3563|M.smegmatis_MC2_155 LPTFMQFVDGVSATESGLRTLPMVAGLLITSTGSGALVGRTGRYKIFPVM
Mvan_3722|M.vanbaalenii_PYR-1 VAPG-------GCDVETKYHCARVIADPERDSGRTLMLDGARHSYIDLQD
: .
Mb2632|M.bovis_AF2122/97 GLQFCTRDEYRYTESLVYPAVSDGARSVLVLGGGDGLAARELLRQPG---
Rv2601|M.tuberculosis_H37Rv GLQFCTRDEYRYTESLVYPAVSDGARSVLVLGGGDGLAARELLRQPG---
MAV_3480|M.avium_104 GLQFSTRDEYRYTESLVYPALGNGARSVLVLGGGDGLAARELLRQPG---
MMAR_2104|M.marinum_M GLQFSTRDEYRYTESLVYPALGDGARSVLVLGGGDGLAARELLRLPR---
MUL_1708|M.ulcerans_Agy99 GLQFSTRDEYRYTESLVYPALGDGARSVLVLGGGDGLAARELLRLPR---
TH_0626|M.thermoresistible__bu GLQFSTRDEHRYTESLVHPALDESTRSVLILGGGDGLAARELLRYPG---
Mflv_0983|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3563|M.smegmatis_MC2_155 GTAIMVVGFLLLSRMDATTPFVLQSLYLFILGTGIGLCMQVLILTVQNTS
Mvan_3722|M.vanbaalenii_PYR-1 PALLQFIYVRAFASVVDASFPSKKALEAYHLGGGGLTFPRYLAATRP---
Mb2632|M.bovis_AF2122/97 -IEQIVQVELDPAVIELARTTLRDVNAGSLDNPRVHVVIDDAMSWLRGAA
Rv2601|M.tuberculosis_H37Rv -IEQIVQVELDPAVIELARTTLRDVNAGSLDNPRVHVVIDDAMSWLRGAA
MAV_3480|M.avium_104 -ISRIVQVELDPAVIEIARTTLRAANGGSLDNPRVRVLTGDAMAWLRGP-
MMAR_2104|M.marinum_M -IERIVQVELDPAVIELARTTMREANGGALDDPRVQVVIGDAMKWLRGTD
MUL_1708|M.ulcerans_Agy99 -IERIVQVELDPAVIELARTTMREANGGALDDPRVQVVIGDAMKWLRGTD
TH_0626|M.thermoresistible__bu -IDSIVQVELDPAVIELARTTLRPVNGGALDDPRVTVVTDDAMRWLREPP
Mflv_0983|M.gilvum_PYR-GCK -----VQIDWSLALAVTAAAVVGALLG-----------------------
MSMEG_3563|M.smegmatis_MC2_155 RFDDLGVATSGVTFFRTIGSSFGAAIFGSLFANFLSSRLVTAIAESGAPP
Mvan_3722|M.vanbaalenii_PYR-1 -GSHNVVSEIDGGVVRIDRDELGSASEAGIEVRVEDGRLGLARLDDDSRD
. . .
Mb2632|M.bovis_AF2122/97 --V-PPAGFDAVIVDLRDPDTPVLGRLYSTEFYALAARALA---------
Rv2601|M.tuberculosis_H37Rv --V-PPAGFDAVIVDLRDPDTPVLGRLYSTEFYALAARALA---------
MAV_3480|M.avium_104 ----NPDRFDAVIVDLPDPDTPVLGRLYSTEFYTLAARALA---------
MMAR_2104|M.marinum_M --SGQSRRFDAVIVDLPDPDTPALGRLYSAEFYALAAHALA---------
MUL_1708|M.ulcerans_Agy99 --SGQSRRFDAVIVDLPDPDTPALGRLYSAEFYALAAHALA---------
TH_0626|M.thermoresistible__bu PDLRPPGGFDAVIVDLPDPDTPVLGRLYSTEFYALVTRALA---------
Mflv_0983|M.gilvum_PYR-GCK ----------ARLTSMVNPDS--LRKAFGWFVLAMSSVILA---------
MSMEG_3563|M.smegmatis_MC2_155 AAGESPKVLHELPPEIAAPIVEAYADSLGLVFLCAAPVALLGFVVSLFLK
Mvan_3722|M.vanbaalenii_PYR-1 -----------LIVGDAFGGVSVPWHLTTVESLTDIRRVLK---------
*
Mb2632|M.bovis_AF2122/97 --PGGLMVVQAGSPYSTPTAFWRIISTIRSAGYAVTPYHVHVPTFGDWGF
Rv2601|M.tuberculosis_H37Rv --PGGLMVVQAGSPYSTPTAFWRIISTIRSAGYAVTPYHVHVPTFGDWGF
MAV_3480|M.avium_104 --PGGLLVVQAGSPFSTPTAYWRTVSTIRAAGYAVTPYHVHVPTFGDWGF
MMAR_2104|M.marinum_M --PDGLMVVQAGSPFSTPTAFWRTVSTIKAAGYAVTPYHVHVPTFGDWGF
MUL_1708|M.ulcerans_Agy99 --PDGLMVVQAGSPFSTPTAFWRTVSTIKAAGYAVTPYHVHVPTFGDWGF
TH_0626|M.thermoresistible__bu --PGGRMVVQAGSPYSTPTAFWRTVSTIASAGYAVTPYHVHVPTFGDWGF
Mflv_0983|M.gilvum_PYR-GCK --QEIHLAVGIAG---------AALTAIAALMTFACSRYAHCPLRRITGI
MSMEG_3563|M.smegmatis_MC2_155 EVPLQELDPTAAVDMGEGFGMPSTEPAEKVLETAISRIMRHSPEIRLRTV
Mvan_3722|M.vanbaalenii_PYR-1 --KDGVYVANLIDYGELAFARAEVSTLTKVFDYVIVAGEAGDVGVDTAAT
.
Mb2632|M.bovis_AF2122/97 ALARLTDIAPT--------------------------------------P
Rv2601|M.tuberculosis_H37Rv ALARLTDIAPT--------------------------------------P
MAV_3480|M.avium_104 VLAQRGDTPPA--------------------------------------P
MMAR_2104|M.marinum_M ALARRGGTAPI--------------------------------------P
MUL_1708|M.ulcerans_Agy99 ALARRGGTAPI--------------------------------------P
TH_0626|M.thermoresistible__bu VLATRGTEPPR--------------------------------------P
Mflv_0983|M.gilvum_PYR-GCK GAARGAHA------------------------------------------
MSMEG_3563|M.smegmatis_MC2_155 AGCPGCDLDVAGLWALLQIYRHSQVFGSATLTAIAERLRVPYEVFEPIFD
Mvan_3722|M.vanbaalenii_PYR-1 PDGGNLVVLAS--------------------------------------D
Mb2632|M.bovis_AF2122/97 AVPSTAPALRFLDQQVLEAATVFSGDIRPRTLDPSTLDNPHIVEDMRHGW
Rv2601|M.tuberculosis_H37Rv AVPSTAPALRFLDQQVLEAATVFSGDIRPRTLDPSTLDNPHIVEDMRHGW
MAV_3480|M.avium_104 KVPPDAPPLRFLDQRVLQAAVVFSGDVGPRPLEPSTLDNPRIVGDMRHGY
MMAR_2104|M.marinum_M AVPADAPSLRFLNQPVLNAATVFSSDVGPTMLEPSTLDNPRIVEDMRRGY
MUL_1708|M.ulcerans_Agy99 AVPADAPSLRFLNQPVLNAATVFSSDVGPTMLEPSTLDNPRIVEDMRPGL
TH_0626|M.thermoresistible__bu TVPANAPELRFLDQRVLDAATVFGKDRPPLTLEPSTLDRPRVVDDIRRGW
Mflv_0983|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3563|M.smegmatis_MC2_155 RLVAGGYALRTGDRLWLTQAGLSQVDAVSTALVGRIIEKLEKSPSFEGRP
Mvan_3722|M.vanbaalenii_PYR-1 RPVDPGALQRVLNTRKTGWTITAGEDLRKWIGDARVLTDDYAPVDQLLDP
Mb2632|M.bovis_AF2122/97 D------------------------------------
Rv2601|M.tuberculosis_H37Rv D------------------------------------
MAV_3480|M.avium_104 D------------------------------------
MMAR_2104|M.marinum_M R------------------------------------
MUL_1708|M.ulcerans_Agy99 RRC----------------------------------
TH_0626|M.thermoresistible__bu Q------------------------------------
Mflv_0983|M.gilvum_PYR-GCK -------------------------------------
MSMEG_3563|M.smegmatis_MC2_155 DRVQVEAALERIAHRMLVQRDWSDDRAELASAAGPAA
Mvan_3722|M.vanbaalenii_PYR-1 YRRQSGE------------------------------