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MISCTTTEATAMSLLLDRFRELAACIPANTAISFVNEKGRVAESMSRADVVSDMGEVAEFLRHHCGLEPG DRAILAYPSGLDFVRGLIGCLAAGVVPVPIYPPDPINPQKTVDRMQRVVASSGAKAVLTSRRYANARRLG TARSIVTGSTVGWPGDLPWHITSRGIGGRRMRGPGTPGAPGRGWSPSPDAPALLQYTSGSTSDPKGVVIT HGNLAHQVDFNRRLLGLGLDARGVFWLPPYHDFGLISVILSGLAGSGEVTLMSPLTFLQRPALWFDVMDR VRATHTAAPNFAYELAVRKTTAEQRAAWDLSSLQVVMSAAEPVREDTTSRFLDAFSGTGLRRDAFCPAYG LAEHTVAVTMFGRSTLSVDRHQLETQRLAVPADGPGSQALIGCGQVADDVDVRIVDPELHVPLADGQVGE IWVDSPSKAAGYWGLPDKSRDTFGARLAGSDDSRSYLRTGDLGLLHDGELYVCGRLKDLLILAGRNIHPQ DIEESLRDCHPAIRPGGIAAFAVDAGDVGDVEGLAVLVEVKADIATEMLSGVADEVQAVVLKNHQLRCSA VVVAPPGSVSKTTSGKVQRARCRTRLLDGTLEAEALLVARLEDAGPPDVPDDELGTAGPVVTSAGAWPAA PGDPLLASVRDQVAAVFGIRAARVDIDQPLSEQGLDSVGFVKLASRLSQAFDRDVPPVDVFNHPTVRGLA HMLRDAEVAGCEHHPPQALLQHPNPARCGPAGHGDDASTRDSFEALLKGAITTGRISEGMHLLRSASQLR LAVQSESGARTWPTAVPTTFTSGPKAPHLIFLCTSVFSSGVHNYARIASEFRGVRAVSAIPLPGFARGEP LPDSPEAAVECLARIVVELVGDEPFVLAGQSSGGKFAYALGKHFEDVRNRNLAGVALLDSHKESDPELTE LLTREILYDVYGESGGQDLFHATRLTAVVSWSDLLPNMYDGPLESDVLFVQCTRPWVMPYGAGDITYPAT EPWSPSNTVRTVAVDHVSLLVEGAKPAAQILEEWISRG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_1876 | - | - | 100% (1018) | long-chain acyl-CoA synthetase |
M. marinum M | MMAR_3099 | - | 0.0 | 63.94% (696) | polyketide synthase and peptide synthetase |
M. marinum M | MMAR_1170 | fadD29_1 | 1e-84 | 34.06% (646) | fatty-acid-CoA ligase FadD29_1 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1217c | fadD21 | 2e-76 | 34.51% (597) | acyl-CoA synthetase |
M. gilvum PYR-GCK | Mflv_1168 | - | 8e-78 | 33.44% (601) | acyl-CoA synthetase |
M. tuberculosis H37Rv | Rv1185c | fadD21 | 2e-76 | 34.51% (597) | acyl-CoA synthetase |
M. leprae Br4923 | MLBr_01234 | - | 1e-73 | 33.33% (600) | acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_3579c | - | 1e-86 | 37.17% (600) | putative acyl-CoA synthase/polyketide synthase |
M. avium 104 | MAV_4122 | - | 1e-101 | 38.47% (590) | AMP-binding enzyme |
M. smegmatis MC2 155 | MSMEG_3465 | - | 2e-74 | 34.95% (555) | acyl-CoA synthetase |
M. thermoresistible (build 8) | TH_4458 | - | 1e-97 | 37.48% (643) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
M. ulcerans Agy99 | MUL_1117 | - | 2e-78 | 35.37% (540) | fatty-acid-CoA ligase |
M. vanbaalenii PYR-1 | Mvan_0999 | - | 1e-96 | 35.08% (724) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_1876|M.marinum_M ---------------------MISCTTTEATAMSLLLDRFRELAACIPAN MAB_3579c|M.abscessus_ATCC_199 --------------------------MQTTYDFTDYFSTVTEWVARQPDQ TH_4458|M.thermoresistible__bu ----------------------------------LLS-LLRQRSERYGDK Mvan_0999|M.vanbaalenii_PYR-1 -----------------------------MFLEDLLSRRLRRHADEFPDE Mb1217c|M.bovis_AF2122/97 ------------------------------MSDSSVLSLLRERAGLQPDD Rv1185c|M.tuberculosis_H37Rv ------------------------------MSDSSVLSLLRERAGLQPDD MLBr_01234|M.leprae_Br4923 ------------------------------MQNSSVLSFLRERAGLQPDD Mflv_1168|M.gilvum_PYR-GCK ---------------MAFHNPFLKDGLIKFPDNGNLVRHVERWAKVRGDK MSMEG_3465|M.smegmatis_MC2_155 MDSGSRTQYEAPTGLLRIEDCLDADGGIVLPPGTTLISLIERNIANVGDS MAV_4122|M.avium_104 --------------------------------METLIDYLHLWEERRPEQ MUL_1117|M.ulcerans_Agy99 -------------------------MAHLPPPHLNLVERLAWRARNQPDE . . MMAR_1876|M.marinum_M TAISFVN-EKGRVAESMSRADVVSDMGEVAEFLRHHCGL--EPGDRAILA MAB_3579c|M.abscessus_ATCC_199 IALGYLE-EGAGELTERAWTYAELVSHATAVAARLREDL--EPGDRTLLL TH_4458|M.thermoresistible__bu IAFDYCTGEQE---HSR-LTYQELDIRARAIAAHLQDQG--VAGERVLVL Mvan_0999|M.vanbaalenii_PYR-1 RILSFLDDRLE---VADSLTFGRLDDRARSVAAGLLDRG--MGGAPVVLS Mb1217c|M.bovis_AF2122/97 AAFTYIDYEQDWAGITETLTWSEVFRRTRIVAHEVRRHC--TTGDRAVIL Rv1185c|M.tuberculosis_H37Rv AAFTYIDYEQDWAGITETLTWSEVFRRTRIVAHEVRRHC--TTGDRAVIL MLBr_01234|M.leprae_Br4923 EAFSFTDYEQDWAGVRKTLTWAQLYQRTLNVAHELRRHG--SIRDRAVIL Mflv_1168|M.gilvum_PYR-GCK MAYRFIDFSTERDGVERDLHWADFSTRNKAVGARLQQVT--EPGDRVAIL MSMEG_3465|M.smegmatis_MC2_155 VAYRYLDYSHGELQVA-ELTWRQLGVRLRAVGAAVQQVA--ARGDRVAVL MAV_4122|M.avium_104 TLFRFVDVDGR---ELEHYTYRSFAERTRELAAYLSTEAGLRAGDRALLV MUL_1117|M.ulcerans_Agy99 LAMVELRGMCG---ETDKATYARLDARARAIAFQLKSLG--NQGDRVLLV . : MMAR_1876|M.marinum_M YPSGLDFVRGLIGCLAAGVVPVPIYPPDPINPQKTVDRMQRVVASSGAKA MAB_3579c|M.abscessus_ATCC_199 YPPGLPFVAAFLGCLAAGVVAVPAPLPD--GRDKAQHRLAGIIADAGTRV TH_4458|M.thermoresistible__bu CPSGLDFITAMFGCFYVGAVAVPVHPPV---HNRLLSRVASIVADVRATS Mvan_0999|M.vanbaalenii_PYR-1 YPPGLDFVSAFCGCLYAGAIAVPAALPQ---SRRTAERLAAVLKDSAARC Mb1217c|M.bovis_AF2122/97 APQGLAYIAAFLGSMQAGAIAVPLSVPQ---IGSHDERVSAVLADASPSV Rv1185c|M.tuberculosis_H37Rv APQGLAYIAAFLGSMQAGAIAVPLSVPQ---IGSHDERVSAVLADASPSV MLBr_01234|M.leprae_Br4923 APQGLDYIIAFLGAMQAGFIAVPLSVPQ---AGSHDERVGAVLADTSPSV Mflv_1168|M.gilvum_PYR-GCK CPQNLDYLVAFFGTLYSGRIAVPLFDPN---EPGHVGRLHAVLDDCTPSA MSMEG_3465|M.smegmatis_MC2_155 APQGLDYVIGFFAAIKAGTIAVPLFAPE---LQGHAERLDTALSDARPTT MAV_4122|M.avium_104 YPPGLEMVAALYACARIGVIAVPVSPPLPMSFESGLAKLGFIARDCQARA MUL_1117|M.ulcerans_Agy99 MGHCLDYVVGFLACAYARRVAVNLPVPR---RAKHLDRLAHVVADCGAEV * : .: . :.* * :: . . MMAR_1876|M.marinum_M VLTSRRYANARRLGTARSIVTGSTVGWPGDLPWHITSRGIGGRRMRGPGT MAB_3579c|M.abscessus_ATCC_199 VLT-------------ESSVAPLIAGWADALPTPIALIATD----AIPVE TH_4458|M.thermoresistible__bu VLT-------------TAATRADLKEILDGLHDGDPLRWLAVD--TIEAD Mvan_0999|M.vanbaalenii_PYR-1 VLT-------------SAAHRAELYSHAG--AAPSVVDVIATD--VLPSR Mb1217c|M.bovis_AF2122/97 ILT-------------TSAVAEAVAEHIHRPNTNNVGPIIEID--SLDLT Rv1185c|M.tuberculosis_H37Rv ILT-------------TSAVAEAVAEHIHRPNTNNVGPIIEID--SLDLT MLBr_01234|M.leprae_Br4923 VLT-------------TSAVADAIAKYVDHSDTDTVPAILEVD--SPNLD Mflv_1168|M.gilvum_PYR-GCK ILT-------------TTAAAEGVRKFFRTRPAKDRPRVIAVD--AVPDE MSMEG_3465|M.smegmatis_MC2_155 VLT-------------TAAVEEAVTGFLDKLSGK-QPHVVVID--EVPDS MAV_4122|M.avium_104 VLSTKQF----------EYDFRMLLGQRHGGQPWSDAGLPELPWFATDGA MUL_1117|M.ulcerans_Agy99 LLTSGP-------------EAKELTASVAADLRLDFLTVLRLDWLLAIPD :*: MMAR_1876|M.marinum_M PGAPGRGWSPSPDAPALLQYTSGSTSDPKGVVITHGNLAHQVDFNRRLLG MAB_3579c|M.abscessus_ATCC_199 LGREFVPVRSAPSDTAFLQYTSGSTNAPKGVIVTHGNLVHNEQELGARIE TH_4458|M.thermoresistible__bu DETSWTPTTVDTDSVAFVQYTSGSTSTPKGVVLTHHNLLANLESISRDAG Mvan_0999|M.vanbaalenii_PYR-1 PGDGRVALP-DPDQVAFLQYTSGSTRSPRGVMVRHGDLAANLNSLREILA Mb1217c|M.bovis_AF2122/97 G-NSPSFRVKDLPSAAYLQYTSGSTRAPAGVMISHRNLQANFQQLMSNYF Rv1185c|M.tuberculosis_H37Rv G-NSPSFRVKDLPSAAYLQYTSGSTRAPAGVMISHRNLQANFQQLMSNYF MLBr_01234|M.leprae_Br4923 VENKSNIRLTDAPSTAYLQYTSGSTRLPAGVMVTHRNLMVNFQQLMADYF Mflv_1168|M.gilvum_PYR-GCK VGATWEPVDVQHDTIAYLQYTSGSTRIPTGVQITHLNLATNVVQVIEALD MSMEG_3465|M.smegmatis_MC2_155 AGADFAPVPVDVDDVSHLQYTSGSTRPPVGVEITHRAVGTNLLQMILSID MAV_4122|M.avium_104 QEFGGAPVPDTPGDVLFLQYTSGSTSDPKGVIVSHKNVIANVSAFTGGS- MUL_1117|M.ulcerans_Agy99 EDWQ--PVAPASKDVCLLQYTSDSTSAPRGVVVTHDNLMFNCAQIQYGFG :****.** * ** : * : : MMAR_1876|M.marinum_M LGLDARGV------FWLPPYHDFGLISVILSGLAGSGEVTLMSPLTFLQR MAB_3579c|M.abscessus_ATCC_199 NDPSFSML------SWLPQFHDMGLIGMLLWPLFYGGTSRFLSPVTFIKH TH_4458|M.thermoresistible__bu QGDEARVV------SWLPLHHDMGLIGGIFGVVHFGGTAYLMPPSSFIQR Mvan_0999|M.vanbaalenii_PYR-1 FDDHATGV------SWLPVFHDMGLIAGVLLPIWSARPQFLMAPATFVRN Mb1217c|M.bovis_AF2122/97 GDRNGVAPPDTTIVSWLPFYHDMGLVLGIIAPILGGYRSELTSPLAFLQR Rv1185c|M.tuberculosis_H37Rv GDRNGVAPPDTTIVSWLPFYHDMGLVLGIIAPILGGYRSELTSPLAFLQR MLBr_01234|M.leprae_Br4923 APTNGVAPLDLTIVSWLPFYHDMGLVLGVVAPILGGWRSELTSPISFLQR Mflv_1168|M.gilvum_PYR-GCK AE-EGDRG-----VSWLPFFHDMGLITVLLSPMLG-HHISFMTPAAFVRR MSMEG_3465|M.smegmatis_MC2_155 LLNRNTHG-----MSWLPLYHDMGLSMIGFPAVYG-GHSTLMSPTAFIRR MAV_4122|M.avium_104 ----EVLVS------WLPQHHDMGLISAYMFILLQGGTTHAMSPLDFLAR MUL_1117|M.ulcerans_Agy99 LTAEDRALS------WLPLYHDMGLILGVLTPIFAGFPVVLADPLSFVKR *** .**:** . : * *: . MMAR_1876|M.marinum_M PALWFDVMDRVRA----THTAAPNFAYELAVR-KTT-AEQRAAWDLSSLQ MAB_3579c|M.abscessus_ATCC_199 PIQWIRAMSKYRA----TVGVAPNFAFDLVAR-RCT-HEALEGVDLSCVR TH_4458|M.thermoresistible__bu PMSWLEAISWHGA----NISVGPNFGYQLCVE-RST-PEERATLDLSTWV Mvan_0999|M.vanbaalenii_PYR-1 PLSWLEAISRYGG----THQGAPNFGYQACVD-AAR-AAGATTFDLRNWR Mb1217c|M.bovis_AF2122/97 PARWLHSLANGSP----SWSAAPNFAFELAVR-KTT-DADIEGLDLGNVL Rv1185c|M.tuberculosis_H37Rv PARWLHSLANGSP----SWSAAPNFAFELAVR-KTT-DADIEGLDLGNVL MLBr_01234|M.leprae_Br4923 PARWIQAMATSSH----PFSAGPNFAFELAAR-RTS-DADIAGLDLGACQ Mflv_1168|M.gilvum_PYR-GCK PGRWIRAMARKPDDTGGVISVAPNFAFDHAAA-RALPKDDEPPLDLSNIK MSMEG_3465|M.smegmatis_MC2_155 PQRWIQALSDESR-FGRVITAAPNFAYEWTAQ-RGVPEHGD-EIDLSNVV MAV_4122|M.avium_104 PSAWLRLISDVRA----THTPVPNFALEYCLREDKVPAAELAGIDLSSLE MUL_1117|M.ulcerans_Agy99 PDLWLRAISDYRI----TFTGGPNFAYDLCA--DAASYTDLSGIDLSCWN * *: : ***. : ** MMAR_1876|M.marinum_M VVMSAAEPVREDTTSRFLDAFSGTGLRRDAFCPAYGLAEHTVAVTMFGR- MAB_3579c|M.abscessus_ATCC_199 SLLNGSEPVQWASIERFTTLLAPFGLAEHAVTPVYGLAEATLFVTGDPHG TH_4458|M.thermoresistible__bu RAYCGAEPVRAATMRRFTEAFAPAGFRADAFHPVYGLAEATLFVSGRPEN Mvan_0999|M.vanbaalenii_PYR-1 VAWNGAEPVRPDTLHQFRDQFALNGFGSECLSPGYGLAEATLVVSGSDGS Mb1217c|M.bovis_AF2122/97 GITSGAERVHPNTLSRFCNRFAPYNFREDMIRPSYGLAEATLYVASRNSG Rv1185c|M.tuberculosis_H37Rv GITSGAERVHPNTLSRFCNRFAPYNFREDMIRPSYGLAEATLYVASRNSG MLBr_01234|M.leprae_Br4923 GIISGSERIHPATLNRFSDRFARINFRDDMMLPSYGLAEGTVYAASRPKG Mflv_1168|M.gilvum_PYR-GCK CILNGSEPISAATVRRFNEAFSPYGFKPEAIKPSYGLAEATLFVSTPPIH MSMEG_3465|M.smegmatis_MC2_155 LII-GSEPVSPSAIADFNKAFAPYGLPATAFKPSYGIAEATLFVATIAPA MAV_4122|M.avium_104 CIVVGAEPLRANTFHQFRERFAPYGLRPEALTGAYGMAESTLIVSIRGRQ MUL_1117|M.ulcerans_Agy99 VALNGAEPIRATTLERFNAALAPLGWAPTCMQPSYGLAENTLAVSTKIPA .:* : : * :: . . **:** *: .: MMAR_1876|M.marinum_M ---STLSVDRHQLETQRLAVPAD-GPGSQALIGCGQVADDVDVRIVDPEL MAB_3579c|M.abscessus_ATCC_199 TPVTTAVVDGEALAENRLVVANE-GAPRSRVLVASGRIGGIEVSVVGADG TH_4458|M.thermoresistible__bu VLPTVRSLDNAALREHRVVPAAADDANAAAVVGCGPAAYGEEIVIVDPAT Mvan_0999|M.vanbaalenii_PYR-1 KPATELTVDESELHVGQVRPRIDDGPGVKRLVGSGRPAAGTEVQIVR-AD Mb1217c|M.bovis_AF2122/97 DKPEVVYFEPDKLSTGSANRCEPKTGTPLLSYG---MPTSPTVRIVDPDT Rv1185c|M.tuberculosis_H37Rv DKPEVVYFEPDKLSTGSANRCEPKTGTPLLSYG---MPTSPTVRIVDPDT MLBr_01234|M.leprae_Br4923 SSPEVVYFEPAKLSEGTVKRCEARTGAPLLSYG---TPKSPIVRIVDSDT Mflv_1168|M.gilvum_PYR-GCK EHPKIISVDRDELNSHRFVQVPDDSPKAVAQAGAGQIGIAEWAVIVDNDT MSMEG_3465|M.smegmatis_MC2_155 AQASVVYFDRDELAQGRAVPVAGDAVDAVAHVSCGQVARSLQAVIVDPGT MAV_4122|M.avium_104 TLTVNKRGLEKNVARVEKALPE-NSNQV-PLVSCGKPLEETVVRVVDPQT MUL_1117|M.ulcerans_Agy99 TEPTVVEIYVAALRQSQVCAPRGDSPSR-RLVSSGRILAGTMVKIVDPET : :* MMAR_1876|M.marinum_M HVPLADGQVGEIWVDSPSKAAGYWGLPDKSRDTFGARLAGSD-------- MAB_3579c|M.abscessus_ATCC_199 -APLPDGEIGEIWLRGTSVAAGYWNLPELSAEIFGATPIGG--------- TH_4458|M.thermoresistible__bu RREFPPDVVGEIWVAGENVAQGYLGKPSESAETFAAHLAD---------- Mvan_0999|M.vanbaalenii_PYR-1 GRVAEPHTLGEIWVRSDSVAQGYWNNPGETSGTFGACLT----------- Mb1217c|M.bovis_AF2122/97 CIECPAGTIGEIWVKGDNVAEGYWNKPDETRHTFGAML-------VHPSA Rv1185c|M.tuberculosis_H37Rv CIECPAGTIGEIWVKGDNVAEGYWNKPDETRHTFGAML-------VHPSA MLBr_01234|M.leprae_Br4923 CIECPTGRVGEIWLHGDNVAEGYWHKPEETQRTFGGKL-------ANPSP Mflv_1168|M.gilvum_PYR-GCK ATELPDGQIGEIWISGQNMGTGYWNKPEETIATFQNLLKSRTTP-SHAEG MSMEG_3465|M.smegmatis_MC2_155 GEELGDGTVGEIWLHGNNIGRGYWNLPEQTRETFGATLRARLRDGTHSGN MAV_4122|M.avium_104 RQALGEGRVGEVWLAGPSKGRGYWNRPQLTAEMFEARLAG---------- MUL_1117|M.ulcerans_Agy99 GHPVGPDRVGEIWLTGRSVAKGYWGRDIQTEEVFAARLPG---------- :**:*: . . . ** : * MMAR_1876|M.marinum_M --DSRSYLRTGDLGLLHDGELYVCGRLKDLLILAGRNIHPQDIEESLRDC MAB_3579c|M.abscessus_ATCC_199 ---TGGWLRTGDLGTLVDGNLFITGRTKDVIIVNGRNLYAHDIEAAARAA TH_4458|M.thermoresistible__bu -SGRGPFLRTGDYGFLLDGELFVTGRLKDLIIIRGRNYHPNDIEATVQEV Mvan_0999|M.vanbaalenii_PYR-1 -TGEGPYLRTGDLGFVDDGELFVIGRLNDVIVIRGVNYYPHDIEYTVERS Mb1217c|M.bovis_AF2122/97 GTPDGSWLRTGDLGFLSEDEMFIVGRMKDMLIVYGRNHYPEDIESTVQEI Rv1185c|M.tuberculosis_H37Rv GTPDGSWLRTGDLGFLSEDEMFIVGRMKDMLIVYGRNHYPEDIESTVQEI MLBr_01234|M.leprae_Br4923 GTPEGPWLRTGDLGFISEDELFIVGRMKDLLIVYGRNHYPEDIESTVQEI Mflv_1168|M.gilvum_PYR-GCK ADADATWVRTGDLGAYHDGELFITGRVKDLVIIDGRNHYPQDLEYSAQEA MSMEG_3465|M.smegmatis_MC2_155 APADARWLRTGDLGVYRDGELYVTGRIADLVVIDGRSHYPHDIETTVADA MAV_4122|M.avium_104 -DDEHSYLRTGDLGFLYEGELFVCGRSKDLIIVRGVNCYPSDIEAVVERS MUL_1117|M.ulcerans_Agy99 -DPAR-YLRTGDLGFCRDDELFVVGRLKDLVIVHGANHYPQDLEETAEGA ::**** * :.:::: ** *:::: * . :. *:* MMAR_1876|M.marinum_M HPAIRPGGIAAFAVDAGDVGD----------------VEGLAVLVEVKAD MAB_3579c|M.abscessus_ATCC_199 APALARGVGAAFAVGT---------------------PERLVLVHEIRPE TH_4458|M.thermoresistible__bu HPALMSGRGAAFAVSPDPSGTEQ-----------------LVIVQEVDRG Mvan_0999|M.vanbaalenii_PYR-1 HPALQPDAGAVIGVER--SGRVD-----------------LVSVSEIRRD Mb1217c|M.bovis_AF2122/97 T----GGRVAAISVPVDHTEK-------------------LVTVIELKLL Rv1185c|M.tuberculosis_H37Rv T----GGRVAAISVPVDHTEK-------------------LVTVIELKLL MLBr_01234|M.leprae_Br4923 T----GGRVAAISVPVDETEK-------------------LVTIIEVKKR Mflv_1168|M.gilvum_PYR-GCK TKALRTGFVAAFSVPANQLPDEVFDNAHAGIKRDPDDSSEQLVIVGERAP MSMEG_3465|M.smegmatis_MC2_155 SPLVRRGHVTAFTVAAQDVP-----GASDGQTQDG------LVVIAERAV MAV_4122|M.avium_104 AKQVRGGCVAALSVEQDDQEA-------------------LVVVAEVRDE MUL_1117|M.ulcerans_Agy99 HPAVRSHFVAVFAEEREDREA-------------------LIVVAEIRRE :.: : MMAR_1876|M.marinum_M -IATEMLSGVADEVQ----AVVLKNHQLRCSAVVVAPPGSVSKTTSGKVQ MAB_3579c|M.abscessus_ATCC_199 NLGDASLDDVLAAVR----TAIFAEFATPLSDLVLVAKGEVARTTSGKIR TH_4458|M.thermoresistible__bu RLGEVDTDELIAAIR----TAVTSQHDIGVHTVVLVDPLRIPTTSSGKIR Mvan_0999|M.vanbaalenii_PYR-1 LVDSIVGDDIVDAIR----RAVARDHQLALQRVVLLRPGGMPKTSSGKIQ Mb1217c|M.bovis_AF2122/97 GDSAGEAMDELDVIKNNVTAAISRSHGLNVADLVLVPPGSIPTTTSGKIR Rv1185c|M.tuberculosis_H37Rv GDSAGEAMDELDVIKNNVTAAISRSHGLNVADLVLVPPGSIPTTTSGKIR MLBr_01234|M.leprae_Br4923 GDSDAEAMQKLVAVKNNITAAISKSHGLNVADLVLVPPGSIPTTTSGKVR Mflv_1168|M.gilvum_PYR-GCK GAHKLDMGPIIDDIR----AAIAVRHGVTVRDVLLTPAGAIPRTSSGKIG MSMEG_3465|M.smegmatis_MC2_155 GTTRADPQPGIDAIR----AAVAHRHGVTVADVRFVPAGAIPRTTSGKLA MAV_4122|M.avium_104 HN-LPDAR----ALAR----AIRRHCHIDPHTIVFAPPRSIPKTTSGKIR MUL_1117|M.ulcerans_Agy99 AERGLDPRDVGQRIAR----AITREHEVSVDAVFLARCGEVPKTTSGKIQ : .: : . :. *:***: MMAR_1876|M.marinum_M RARCRTRLLDGTLEAEALLVARLEDAGPPDVPDDELGTAGPVVTSAGAWP MAB_3579c|M.abscessus_ATCC_199 RTHMR-------------------------------------ASYEGGRI TH_4458|M.thermoresistible__bu RRTCRQRFLDGELDAFAEWRLATPRPAQPVPAADEQAD---EQAGAGPGA Mvan_0999|M.vanbaalenii_PYR-1 RARCRDELGRSGLPVVHDWQASPAR------QATIDFD---LESLSQPGM Mb1217c|M.bovis_AF2122/97 RAACVEQYRLQQFTRLDG-------------------------------- Rv1185c|M.tuberculosis_H37Rv RAACVEQYRLQQFTRLDG-------------------------------- MLBr_01234|M.leprae_Br4923 RTACVEQYRRQQFSRLDG-------------------------------- Mflv_1168|M.gilvum_PYR-GCK RRACRSAYLDGSLRSGKVANAFPDEVD----------------------- MSMEG_3465|M.smegmatis_MC2_155 RRACRAQYLEGKLGAH---------------------------------- MAV_4122|M.avium_104 RASTRQLWLDGALPTFSSWVNPAATRGHDGTAAGAGPLERFANLIESYDL MUL_1117|M.ulcerans_Agy99 RSLCRELLRQGGLALH-------------------GALEK---------- * MMAR_1876|M.marinum_M AAPGDPLLASVRDQVAAVFGIRAARVDIDQPLSEQGLDSVGFVKLASRLS MAB_3579c|M.abscessus_ATCC_199 TAFADPRLASAGGDVVR--------------------------------- TH_4458|M.thermoresistible__bu GPGADEIRAWFVAQLAGELGLSPDDIDTGQPFAYYGLDSVRAIQLMTALE Mvan_0999|M.vanbaalenii_PYR-1 ------LERQLADWLRQELSIS--DLTWSTPLTELGIDSLKGVELVNVLS Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 TGDEDCSFADLGIDSLALAELRNDMQALLAEHGAAELADEVNTRLLQRLT MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M QAFDRDVPPVDVFNHPTVRGLAHMLRDAEVAGCEHHPPQALLQHPNPARC MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu AWSGIKVAPTLAYDHPTIDLAAEHLAGLTHT----ATSTAADAGVSTGAG Mvan_0999|M.vanbaalenii_PYR-1 AAFDFTFPPTSMLDHPSIAS----LAGLIRD----AKLGAGHRAASN--- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 VAEFFSLIRQFGEGSGQPLDALRRALDQISAEYEAHEAAQMRADAALPLP MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M GPAGHGDDASTRDSFEALLKGAITTGRISEGMHLLRSASQLRLAVQSESG MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu RRPEHGPAPDRADEPIAIIGIGCRFPGADGPAAYWRLLREGRDAITATPP Mvan_0999|M.vanbaalenii_PYR-1 -RPDAG-------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 DPAPARAGTPTDILLTGATGFLGPFLLSSLLARTPYTVHALVRATDPGHG MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M ARTWPTAVPTTFTSGPKAPHLIFLCTSVFSSGVHNYARIASEFRGVRAVS MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu ERWDTDSVGDGTRWGGFLERIDGFDAGFFGISPREAVRIDPQQRLLLEVA Mvan_0999|M.vanbaalenii_PYR-1 ----VYSAG----------QIDALD---------EAALVDLLQQR----- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 LDRIVASLRKAQLWTPALEAEVRARVRVICGDLAEPALGIGEPAFARLAR MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M AIPLPGFARGEPLPDSPEAAVECLAR------------IVVELVGDEPFV MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu WEALEDAGLVPDRLAGSRTGVFTGVSTYDYLHLQLSHPELIDAYSGTGTA Mvan_0999|M.vanbaalenii_PYR-1 ---------VDDILDGGRS------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 DVDAVVHNGALVNYVRTYDALRPTNVEGTRELLRLAMTDHAKTFHLVSST MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M LAGQSSGGKFAYALGKHFEDVRNRNLAGVALLDSHKESDPELTELLTREI MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu SSIAANRLSYVFDFRGPSLTLDSACSSSLVAVHQACRSLRDGECDLALAG Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 FIYGWSTQPVVGEWDANEKMAGLDFGYSQTKWVAEQLALAAQRKGLDVRI MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M LYDVYGESGGQDLFHATRLTAVVSWSDLLPNMYDGPLESDVLFVQCTRPW MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu GVNIMLSAGIGLNFTRAGVMATDGRCKTFDARADGWVRGEGAGIVVLKPL Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 YRPSLISPTRSGFGSQDDILVRLTAFMIEHGLAVNALNQISLLPADLIAD MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M VMPYGAGDITYPATEPWSPSNTVRTVAVDHVSLLVEGAKPAAQILEEWIS MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu REALADEDPIYAVIRGSAVNQDGRTNGLMAPSRTAQEVVLTDAYRRAGVS Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 HIVALMDLPDESGSVFNMTADDYYNLTDVTRILSERYGYRFDYHDIDSFA MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M RG------------------------------------------------ MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu PGVVQYVEAQGIGTPVGDAIEVGALGTVLAEDRPPDSPCLIGSVKTNIGH Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 EQLNRRCTPDDQMYPLVDFLTRSADKIAAMRDKRYDNTQYRHRRGLVPVR MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu LEAAAGIAGLIKVALALRHRMIPPTLNFTEPNPTIEFDKLPVRVAQTLTP Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 LREPALTETVDHLVRFLRTERMITEVEDEAQRSA---------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu WPDDSGRAVAGVSAFGFGGTNAHVVLAEAPQVRAAATADDHADGFVEILP Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu LSARSQAALDALAERYESALTGGVPPADLCHTAGARRAHHDHRLAVVGAS Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu RAELIGALAAYRRGEPHPGVFTGRSQSGHRSGVVFVFSDEGSQWRGMAQR Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu LYAEDQVFRTALAECDRALRRHMEISPLSELLADPSHSRMDEVTIASPAL Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu FAVQVALAALWQSWGVEPAAVIGHRMGEVAAAHVAGVLGLDDAAALLCGR Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu TRLSRLASTGAVREGLDGLLANLRPDDPRIPLYSTVTGDAVTGRGFGAAH Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu WMENLHSPVRFSAAVRRLLGRGHDAFLEISAHPMLLSAVQEDAADLGRSC Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu TTLVSMRRGECGRDVLMTSLAALYASGHAVDWARVHPHGSHCTAAPTYPW Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu QRQRFWLDIDRCDTGDGAGTGGTAERTVVPAPLPAPSASAAPTVDEVLLC Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu ADQRERRELLESYLRDRVAAELGVLPPLLDVAAPLSTLGIDSLTAAELRA Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu RVERDLGIVIPVAQLLNGPSVSDLAEWISTTMVGFGSTTPEPESAGVPGR Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu SRPPDGAVASGSGDGGRWIELLNQMPEVSDDTVDELLRQLLAAGENHDDT Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1217c|M.bovis_AF2122/97 -------------------------------------------------- Rv1185c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mflv_1168|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_3465|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4122|M.avium_104 -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- MMAR_1876|M.marinum_M --- MAB_3579c|M.abscessus_ATCC_199 --- TH_4458|M.thermoresistible__bu QLH Mvan_0999|M.vanbaalenii_PYR-1 --- Mb1217c|M.bovis_AF2122/97 --- Rv1185c|M.tuberculosis_H37Rv --- MLBr_01234|M.leprae_Br4923 --- Mflv_1168|M.gilvum_PYR-GCK --- MSMEG_3465|M.smegmatis_MC2_155 --- MAV_4122|M.avium_104 --- MUL_1117|M.ulcerans_Agy99 ---