For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
QTTYDFTDYFSTVTEWVARQPDQIALGYLEEGAGELTERAWTYAELVSHATAVAARLREDLEPGDRTLLL YPPGLPFVAAFLGCLAAGVVAVPAPLPDGRDKAQHRLAGIIADAGTRVVLTESSVAPLIAGWADALPTPI ALIATDAIPVELGREFVPVRSAPSDTAFLQYTSGSTNAPKGVIVTHGNLVHNEQELGARIENDPSFSMLS WLPQFHDMGLIGMLLWPLFYGGTSRFLSPVTFIKHPIQWIRAMSKYRATVGVAPNFAFDLVARRCTHEAL EGVDLSCVRSLLNGSEPVQWASIERFTTLLAPFGLAEHAVTPVYGLAEATLFVTGDPHGTPVTTAVVDGE ALAENRLVVANEGAPRSRVLVASGRIGGIEVSVVGADGAPLPDGEIGEIWLRGTSVAAGYWNLPELSAEI FGATPIGGTGGWLRTGDLGTLVDGNLFITGRTKDVIIVNGRNLYAHDIEAAARAAAPALARGVGAAFAVG TPERLVLVHEIRPENLGDASLDDVLAAVRTAIFAEFATPLSDLVLVAKGEVARTTSGKIRRTHMRASYEG GRITAFADPRLASAGGDVVR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_3579c | - | - | 100% (581) | putative acyl-CoA synthase/polyketide synthase |
M. abscessus ATCC 19977 | MAB_1174c | - | 7e-99 | 40.28% (566) | acyl-CoA synthetase |
M. abscessus ATCC 19977 | MAB_1915 | - | 1e-94 | 37.72% (562) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1960 | fadD31 | 1e-84 | 36.63% (576) | acyl-CoA synthetase |
M. gilvum PYR-GCK | Mflv_2901 | - | 2e-99 | 38.43% (575) | acyl-CoA synthetase |
M. tuberculosis H37Rv | Rv1521 | fadD25 | 8e-85 | 36.78% (571) | acyl-CoA synthetase |
M. leprae Br4923 | MLBr_01234 | - | 6e-85 | 36.22% (566) | acyl-CoA synthetase |
M. marinum M | MMAR_0468 | - | 2e-92 | 40.77% (547) | fatty-acid-CoA ligase |
M. avium 104 | MAV_2777 | - | 3e-86 | 36.10% (579) | acyl-CoA synthetase |
M. smegmatis MC2 155 | MSMEG_4301 | - | 4e-96 | 39.18% (564) | acyl-CoA synthetase |
M. thermoresistible (build 8) | TH_4458 | - | 1e-101 | 39.54% (564) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
M. ulcerans Agy99 | MUL_1117 | - | 6e-91 | 40.40% (547) | fatty-acid-CoA ligase |
M. vanbaalenii PYR-1 | Mvan_3604 | - | 2e-96 | 38.86% (579) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment Mb1960|M.bovis_AF2122/97 MNDGSRQELRVRSGLLQIEDCLDADGGIALPAGTTLISLIERNIKYVGDL MAV_2777|M.avium_104 MDDALRRDDGVP-GLLRIEDCLDADGGVALPPGVNLISLIDRNIANVGDT Mflv_2901|M.gilvum_PYR-GCK -----------MSPELRLDDYLDHEGNIVIPPGTTLTSFLGRNAAEFGDT Mvan_3604|M.vanbaalenii_PYR-1 -----------MSPILRLDDYLDREGNIAIPAGVTLTAFLARNVAELGEA MSMEG_4301|M.smegmatis_MC2_155 ---------------MKIEDYLDADGNIAIPDGVTLTSYFDRNVAELADT MAB_3579c|M.abscessus_ATCC_199 --------------------------MQTTYDFTDYFSTVTEWVARQPDQ TH_4458|M.thermoresistible__bu -----------------------------------LLSLLRQRSERYGDK MMAR_0468|M.marinum_M ----------------MNESIPGGRVAHLPPPHLNLVERLAWRARNQPDE MUL_1117|M.ulcerans_Agy99 -------------------------MAHLPPPHLNLVERLAWRARNQPDE Rv1521|M.tuberculosis_H37Rv ----------------------------MSVVESSLPGVLRERASFQPND MLBr_01234|M.leprae_Br4923 ------------------------------MQNSSVLSFLRERAGLQPDD . : Mb1960|M.bovis_AF2122/97 VAYRYLDHARSAAGCALEVTWTQFGMRLAAIGAHVQRFAGPGDRVAILAP MAV_2777|M.avium_104 VAYRYLDYSGSDDGTAHEVTWSQFGVRLEAIGARIQQVASRGERVAVLAP Mflv_2901|M.gilvum_PYR-GCK PAYRYLDFEHD---RTIELTWAQLRTRLDAVGARLQQVTRPGDRVAILTP Mvan_3604|M.vanbaalenii_PYR-1 PAYRYLDFDHD---CTVELSWTQLGARLSAVGARLQQVTQRGDRVAVLTP MSMEG_4301|M.smegmatis_MC2_155 PAYRYLDFEHDG--RVVELTWKELDTRVRAVGARLQQVTKLGDRVAILCP MAB_3579c|M.abscessus_ATCC_199 IALGYLEEGAG-ELTERAWTYAELVSHATAVAARLREDLEPGDRTLLLYP TH_4458|M.thermoresistible__bu IAFDYCTG----EQEHSRLTYQELDIRARAIAAHLQDQGVAGERVLVLCP MMAR_0468|M.marinum_M LAMVELRG--M-RGETDKATYARLDARARAIAFQLKSLGNQGDRVLLVMG MUL_1117|M.ulcerans_Agy99 LAMVELRG--M-CGETDKATYARLDARARAIAFQLKSLGNQGDRVLLVMG Rv1521|M.tuberculosis_H37Rv KALTFIDYERSWDGVEETLTWSQLYRRTLNLAAQLREHGSTGDRALILAP MLBr_01234|M.leprae_Br4923 EAFSFTDYEQDWAGVRKTLTWAQLYQRTLNVAHELRRHGSIRDRAVILAP * :: .: : :. .:: :*. :: Mb1960|M.bovis_AF2122/97 QGIDYVCGFYAAIKAGTVAVPLFAP-ELPGHAERLDTALRDSEPAVILTT MAV_2777|M.avium_104 QGIDYVAGFYAAVKAGTIAVPLFAP-ELPGHAERLDTALRDSQPSVLLTT Mflv_2901|M.gilvum_PYR-GCK QGVEYVIGFFAAIEAGAIAVPLFAP-ELPGHSERLHAVLADAQPSVVLTT Mvan_3604|M.vanbaalenii_PYR-1 QGVEYVVGFFAAILAGAIAVPLFAP-ELPGHTDRLDAVLKDAEPSVVLTT MSMEG_4301|M.smegmatis_MC2_155 QGVDYVVSFFAAIQAGAIAVPLFSP-ELPGHAERLEAVLADATPSVVLTT MAB_3579c|M.abscessus_ATCC_199 PGLPFVAAFLGCLAAGVVAVPAPLPDGRDKAQHRLAGIIADAGTRVVLTE TH_4458|M.thermoresistible__bu SGLDFITAMFGCFYVGAVAVPVHPP-VHNRLLSRVASIVADVRATSVLTT MMAR_0468|M.marinum_M NCLDYVVGFLACAYARRVAVNLPVP-RRAKHLDRLAHVVADCGAEVLLTS MUL_1117|M.ulcerans_Agy99 HCLDYVVGFLACAYARRVAVNLPVP-RRAKHLDRLAHVVADCGAEVLLTS Rv1521|M.tuberculosis_H37Rv QSLDYVVSFIASLQAGIVAVPLSIP-QGGAHDERTVSVFADTAPAIVLTA MLBr_01234|M.leprae_Br4923 QGLDYIIAFLGAMQAGFIAVPLSVP-QAGSHDERVGAVLADTSPSVVLTT : :: .: .. . :** * * . * . :** Mb1960|M.bovis_AF2122/97 AAAKNAVEGFLNNVPRLRKPTVLVID--QIPDREGELFVPVELDIDAVSH MAV_2777|M.avium_104 TVARDAVEQFLAGHPHLHRPRVIAID--EIPDSAAESFAPTELGMDDVSH Mflv_2901|M.gilvum_PYR-GCK TATAEPVREFLRALPHNRRPRLIAVD--AVPDSVGVGFQRAPLQTDDVAY Mvan_3604|M.vanbaalenii_PYR-1 TAAAQPVRDFIRKLPRDRRPRIIAVD--AVPDSVGTDFTPAPLQTDDIAY MSMEG_4301|M.smegmatis_MC2_155 TAAAEAVGAFVRKLPHAGRPRMIAVD--AVPAAVGATFTPAQLHTDGIAY MAB_3579c|M.abscessus_ATCC_199 SSVAPLIAGWADALP--TPIALIATD--AIPVELGREFVPVRSAPSDTAF TH_4458|M.thermoresistible__bu AATRADLKEILDGLHDGDPLRWLAVD--TIEADDETSWTPTTVDTDSVAF MMAR_0468|M.marinum_M GPEAKELTVSVAADLRLDFLTVLRLD--WLLAIPDEDWQPVAPASKDVCL MUL_1117|M.ulcerans_Agy99 GPEAKELTASVAADLRLDFLTVLRLD--WLLAIPDEDWQPVAPASKDVCL Rv1521|M.tuberculosis_H37Rv SSVVDNVVEYVQPQPGQNAPAVIEVDRLDLDARPSSGSRSAAHGHPDILY MLBr_01234|M.leprae_Br4923 SAVADAIAKYVDHSDTDTVPAILEVDSPNLDVENKSNIR--LTDAPSTAY : : * : Mb1960|M.bovis_AF2122/97 LQYTSGSTRPPVGVEITHRAVGTNLVQMILSIDL-----LNRNTHGVSWL MAV_2777|M.avium_104 LQYTSGSTRPPVGVEITHRAVGTNLVQMILSIDL-----LDRNTHGVSWL Mflv_2901|M.gilvum_PYR-GCK LQYTSGSTRAPAGVKITHRSACTNVVQMVLSVG------LDPDINSVSWL Mvan_3604|M.vanbaalenii_PYR-1 LQYTSGSTRAPAGVEITHRSACTNIVQMVLSVG------LDPDIQSVSWL MSMEG_4301|M.smegmatis_MC2_155 LQYTSGSTRTPAGVEITHRGVCTNVLQMIISVG------LDWNIRSVSWL MAB_3579c|M.abscessus_ATCC_199 LQYTSGSTNAPKGVIVTHGNLVHNEQELGARIE------NDPSFSMLSWL TH_4458|M.thermoresistible__bu VQYTSGSTSTPKGVVLTHHNLLANLESISRDAG------QGDEARVVSWL MMAR_0468|M.marinum_M LQYTSGSTSAPRGVVVTHDNLMFNCAQIQYGFG------LTAEDRALSWL MUL_1117|M.ulcerans_Agy99 LQYTSDSTSAPRGVVVTHDNLMFNCAQIQYGFG------LTAEDRALSWL Rv1521|M.tuberculosis_H37Rv LQYTSGSTRTPAGVMVSNKNLFANFEQIMTSYYGVYGKVAPPGSTVVSWL MLBr_01234|M.leprae_Br4923 LQYTSGSTRLPAGVMVTHRNLMVNFQQLMADYFAPTNGVAPLDLTIVSWL :****.** * ** ::: * .: :*** Mb1960|M.bovis_AF2122/97 PLYHDMGLS-MIGFPAVYGGHSTLMSPTAFVRRPLRWIQALSEGSRTGRV MAV_2777|M.avium_104 PLYHDMGLS-MIGFPAVYGGHSTLMSPAAFVRRPQRWIKALSDGSRHGNV Mflv_2901|M.gilvum_PYR-GCK PLFHDMGLL-MIMFPALAGGYLTLMSPVAFVRRPYRWIKELGADDRP--M Mvan_3604|M.vanbaalenii_PYR-1 PLFHDMGLL-MIMFPAVAGGHLTLMSPVAFVRRPYRWIKELGATDAP--T MSMEG_4301|M.smegmatis_MC2_155 PLFHDMGLL-MIMFPALCGGHITLMSPVSFVRRPYRWIKELGASDVP--T MAB_3579c|M.abscessus_ATCC_199 PQFHDMGLIGMLLWPLFYGGTSRFLSPVTFIKHPIQWIRAMSKYRAT--- TH_4458|M.thermoresistible__bu PLHHDMGLIGGIFGVVHFGGTAYLMPPSSFIQRPMSWLEAISWHGAN--- MMAR_0468|M.marinum_M PLYHDMGLILGVLTPIFAGFPVVLADPLSFVKRPDLWLRAISDYRIT--- MUL_1117|M.ulcerans_Agy99 PLYHDMGLILGVLTPIFAGFPVVLADPLSFVKRPDLWLRAISDYRIT--- Rv1521|M.tuberculosis_H37Rv PFYHDMGFVLGLILPILAGIPAVLTSPIGFLQRPARWIQMLASNTLA--- MLBr_01234|M.leprae_Br4923 PFYHDMGLVLGVVAPILGGWRSELTSPISFLQRPARWIQAMATSSHP--- * .****: : * : * *:::* *:. :. Mb1960|M.bovis_AF2122/97 VTAAPNFAYEWAAQRGLPAQGDDVDLSNVV-LIIGSEPVSIDAVTTFNKA MAV_2777|M.avium_104 VTAAPNFAYEWAAQRGLPGGGEDIDLRNVV-MIIGSEPVSMDAIRTFNKA Mflv_2901|M.gilvum_PYR-GCK FAAAPNFAFALAAQRGLPPEGEELDLSNVAGLINGSEPISVAAVEAFNAA Mvan_3604|M.vanbaalenii_PYR-1 FAAAPNFAFELAAERGLPPAGDTLDLSNVAGLINGSEPVNISSVEKFNAA MSMEG_4301|M.smegmatis_MC2_155 FAAAPNFAYELAAHRGLPPAGDELDLSNVAGLINGSEPVSMASINVFNEA MAB_3579c|M.abscessus_ATCC_199 VGVAPNFAFDLVARRCTHEALEGVDLSCVRSLLNGSEPVQWASIERFTTL TH_4458|M.thermoresistible__bu ISVGPNFGYQLCVERSTPEERATLDLSTWVRAYCGAEPVRAATMRRFTEA MMAR_0468|M.marinum_M FTGGPNFAYDLCADAASYADLSGIDLSCWNVALNGAEPIRATTLERFNAA MUL_1117|M.ulcerans_Agy99 FTGGPNFAYDLCADAASYTDLSGIDLSCWNVALNGAEPIRATTLERFNAA Rv1521|M.tuberculosis_H37Rv FTAAPNFAFDLASRKTKDEDMEGLDLGGVHGILNGSERVQPVTLKRFIDR MLBr_01234|M.leprae_Br4923 FSAGPNFAFELAARRTSDADIAGLDLGACQGIISGSERIHPATLNRFSDR . .***.: :** *:* : :: * Mb1960|M.bovis_AF2122/97 FAPYGLPRTAFKPSYGIAEATLLVATIDHAAEPTVVYLDPEQLGAGHATR MAV_2777|M.avium_104 FAPYGLPRTAFKPSYGIAEATLFVATIAPRAEATAVYFDRRQLGAGHAVR Mflv_2901|M.gilvum_PYR-GCK FAPYGLKQTVIKPSYGMAEATLFVSTTPPDSALKAVYVDRKQLTAGRAVI Mvan_3604|M.vanbaalenii_PYR-1 FAPYGLAPTVVKPSYGMAEATLFVSTTAPDARPEATYLDREKLTVGHAVR MSMEG_4301|M.smegmatis_MC2_155 FAPYGLPPTAVKPSYGMAEATLFVSTIGPAAHPSAVYLDREELGAGRAVE MAB_3579c|M.abscessus_ATCC_199 LAPFGLAEHAVTPVYGLAEATLFVTGDPHGTPVTTAVVDGEALAENRLVV TH_4458|M.thermoresistible__bu FAPAGFRADAFHPVYGLAEATLFVSGRPENVLPTVRSLDNAALREHRVVP MMAR_0468|M.marinum_M LAPLGWAPTYMQPSYGLAENTLAVSTKIPATEPTVVEIDVAALRQSQVCA MUL_1117|M.ulcerans_Agy99 LAPLGWAPTCMQPSYGLAENTLAVSTKIPATEPTVVEIYVAALRQSQVCA Rv1521|M.tuberculosis_H37Rv FAPFNLDPKAIRPSYGMAEATVYVATRKAGQPPKIVQFDPQKLPDGQAER MLBr_01234|M.leprae_Br4923 FARINFRDDMMLPSYGLAEGTVYAASRPKGSSPEVVYFEPAKLSEGTVKR :* . . * **:** *: .: . * Mb1960|M.bovis_AF2122/97 VAPDAPNAVVHVSCGHVARSLWAVIVDPDTGPEAGAELPDGEIGEVWLQG MAV_2777|M.avium_104 VPANAPDAVAAVSCGQVARSARAGIVA------DGAELPDGQVGEIWLHG Mflv_2901|M.gilvum_PYR-GCK VDSDHPDATVQVSCGNVARSQWAVIVDP--ATDC--ELPDGCVGEIWLHG Mvan_3604|M.vanbaalenii_PYR-1 VDPGHPDAVAQVSCGTVSRSQWAAIVDP--GTET--EQPDGRVGEIWLHG MSMEG_4301|M.smegmatis_MC2_155 VPEDDPRAIAQVSCGKIARSQWAVIVDP--NSDTGAELPDGHVGEIWLYG MAB_3579c|M.abscessus_ATCC_199 ANEGAPRSRVLVASGRIG-GIEVSVVG-----ADGAPLPDGEIGEIWLRG TH_4458|M.thermoresistible__bu AAADDANAAAVVGCGPAAYGEEIVIVDP----ATRREFPPDVVGEIWVAG MMAR_0468|M.marinum_M PRGDSP-SRRLVSSGRILAGTMVKIVDP----ETGHPVGPDRVGEIWLTG MUL_1117|M.ulcerans_Agy99 PRGDSP-SRRLVSSGRILAGTMVKIVDP----ETGHPVGPDRVGEIWLTG Rv1521|M.tuberculosis_H37Rv TESDGGTPLVSYG---IVDTQLVRIVDP----DTGIERPAGTIGEIWVHG MLBr_01234|M.leprae_Br4923 CEARTGAPLLSYG---TPKSPIVRIVDS----DTCIECPTGRVGEIWLHG . . :* . :**:*: * Mb1960|M.bovis_AF2122/97 DNVARGYWGRPEETRMTFGARLQSPLAEGSHADGSAIDDTWLRTGDLGVY MAV_2777|M.avium_104 NNIGRGYWGMPEETRRVFGATLRSRLPDGSHAAGADPDGSWLRTGDLGVY Mflv_2901|M.gilvum_PYR-GCK DNIGNGYWERPEETELTFRNKLQSRLARGSHAERSADSALWLRTGDLGVY Mvan_3604|M.vanbaalenii_PYR-1 DNIGRGYWGRPKETELTFQNKLQARLPAGSHAANCPENALWLRTGDLGVY MSMEG_4301|M.smegmatis_MC2_155 DNVGKGYWGRPHETEVSFHNKLQSRLPQGSHAAGAPDGAAWFRTGDLGMY MAB_3579c|M.abscessus_ATCC_199 TSVAAGYWNLPELSAEIFGATPIG------------GTGGWLRTGDLGTL TH_4458|M.thermoresistible__bu ENVAQGYLGKPSESAETFAAHLADS-----------GRGPFLRTGDYGFL MMAR_0468|M.marinum_M RSVAKGYWGRDIQTEEVFAARLPG------------DPARYLRTGDLGFC MUL_1117|M.ulcerans_Agy99 RSVAKGYWGRDIQTEEVFAARLPG------------DPARYLRTGDLGFC Rv1521|M.tuberculosis_H37Rv DNVAIGYWQKPEATERTFSATIVNP-------SEGTPAGPWLRTGDSGFL MLBr_01234|M.leprae_Br4923 DNVAEGYWHKPEETQRTFGGKLANP-------SPGTPEGPWLRTGDLGFI .:. ** : * ::**** * Mb1960|M.bovis_AF2122/97 LDGELYITGRIADLLTIDGRNHYPQDIEATAAEASPMVRRGYITAFTVPA MAV_2777|M.avium_104 LDGELYVTGRIADLVRIDGRNHYPQDIEATVAEASPMVRRGYVTAFSVPA Mflv_2901|M.gilvum_PYR-GCK LDGELYITGRIKDLIIVDGRNHYPQDIEATAAAASPSVRAGFVAAFSVPG Mvan_3604|M.vanbaalenii_PYR-1 LDGQLYITGRIKDLVIVDGRNHYPQDIEATAGEASTSVRSGFVAAFSVPG MSMEG_4301|M.smegmatis_MC2_155 LGGELYITGRIKDMVIVDGRNHYPQDLEATVAEASSQVRAGYIAAFSVPS MAB_3579c|M.abscessus_ATCC_199 VDGNLFITGRTKDVIIVNGRNLYAHDIEAAARAAAPALARGVGAAFAVG- TH_4458|M.thermoresistible__bu LDGELFVTGRLKDLIIIRGRNYHPNDIEATVQEVHPALMSGRGAAFAVSP MMAR_0468|M.marinum_M RDDELFVVGRLKDLVIVHGANHYPQDLEETAEGAHPAVRSHFVAVFAEER MUL_1117|M.ulcerans_Agy99 RDDELFVVGRLKDLVIVHGANHYPQDLEETAEGAHPAVRSHFVAVFAEER Rv1521|M.tuberculosis_H37Rv SEGELFIMGRIKDLLIVYGRNHSPDDIEATIQTIS----PGRCAAIAVSE MLBr_01234|M.leprae_Br4923 SEDELFIVGRMKDLLIVYGRNHYPEDIESTVQEIT----GGRVAAISVPV .:*:: ** *:: : * * ..*:* : :.:: Mb1960|M.bovis_AF2122/97 SDGDDRNQRLVIIAERAAG-TSRSDPRP----ALDAIRAAVCNRHGLSVA MAV_2777|M.avium_104 VD-DPEAGRLVVVAERAAG-TSRQDPRP----AIEAIRAAVAQRHELAVA Mflv_2901|M.gilvum_PYR-GCK EG----REEVVIVAERAPG-AGRAEAAP----IQEAIRAEVSRKHAIPVR Mvan_3604|M.vanbaalenii_PYR-1 DG----REEAVIVAERAPG-AGRAEAAP----IQESIRAAVSRRHALPVK MSMEG_4301|M.smegmatis_MC2_155 EH----GERLVIVAERAPG-AGRADPAP----IVDAIRAAISKRHAVAVH MAB_3579c|M.abscessus_ATCC_199 -----TPERLVLVHEIRPENLGDASLDD----VLAAVRTAIFAEFATPLS TH_4458|M.thermoresistible__bu DP--SGTEQLVIVQEVDRGRLGEVDTDE----LIAAIRTAVTSQHDIGVH MMAR_0468|M.marinum_M E----DREALIVVAEIRREAERGLDPRD----VGQRIARAITREHEVSVD MUL_1117|M.ulcerans_Agy99 E----DREALIVVAEIRREAERGLDPRD----VGQRIARAITREHEVSVD Rv1521|M.tuberculosis_H37Rv HG----AEKLVAIIELKKKDESDDEAAERLGFVKREVTSAISKSHGLSVA MLBr_01234|M.leprae_Br4923 DE----TEKLVTIIEVKKRGDSDAEAMQKLVAVKNNITAAISKSHGLNVA : : * . : : . : Mb1960|M.bovis_AF2122/97 DLSFLPAGAIPRTTSGKLARQACRAQYLSGRLGVH--------------- MAV_2777|M.avium_104 DVRLLPAGAIPRTTSGKLARRACRAQYLDGSLGTR--------------- Mflv_2901|M.gilvum_PYR-GCK DVKLVRSGVIPRTTSGKLARRSCRASYLDGTL------------------ Mvan_3604|M.vanbaalenii_PYR-1 DVKLVAAGVIPRTTSGKLARQACRAAYLNGEL------------------ MSMEG_4301|M.smegmatis_MC2_155 DIKLVAAGSIPRTTSGKLARRACQAQYLAELQTS---------------- MAB_3579c|M.abscessus_ATCC_199 DLVLVAKGEVARTTSGKIRRTHMRASYEGGRITAFADPRLAS-------- TH_4458|M.thermoresistible__bu TVVLVDPLRIPTTSSGKIRRRTCRQRFLDGELDAFAEWRLATPRPAQPVP MMAR_0468|M.marinum_M AVFLARCGEVPKTTSGKIQRSLCRELLRQGGLALHGALEK---------- MUL_1117|M.ulcerans_Agy99 AVFLARCGEVPKTTSGKIQRSLCRELLRQGGLALHGALEK---------- Rv1521|M.tuberculosis_H37Rv DLVLVSPGSIPITTSGKIRRAQCVELYRQDEFTRLDA------------- MLBr_01234|M.leprae_Br4923 DLVLVPPGSIPTTTSGKVRRTACVEQYRRQQFSRLDG------------- : : :. *:***: * Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -----------------AGGDVVR-------------------------- TH_4458|M.thermoresistible__bu AADEQADEQAGAGPGAGPGADEIRAWFVAQLAGELGLSPDDIDTGQPFAY MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu YGLDSVRAIQLMTALEAWSGIKVAPTLAYDHPTIDLAAEHLAGLTHTATS MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu TAADAGVSTGAGRRPEHGPAPDRADEPIAIIGIGCRFPGADGPAAYWRLL MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu REGRDAITATPPERWDTDSVGDGTRWGGFLERIDGFDAGFFGISPREAVR MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu IDPQQRLLLEVAWEALEDAGLVPDRLAGSRTGVFTGVSTYDYLHLQLSHP MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu ELIDAYSGTGTASSIAANRLSYVFDFRGPSLTLDSACSSSLVAVHQACRS MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu LRDGECDLALAGGVNIMLSAGIGLNFTRAGVMATDGRCKTFDARADGWVR MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu GEGAGIVVLKPLREALADEDPIYAVIRGSAVNQDGRTNGLMAPSRTAQEV MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu VLTDAYRRAGVSPGVVQYVEAQGIGTPVGDAIEVGALGTVLAEDRPPDSP MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu CLIGSVKTNIGHLEAAAGIAGLIKVALALRHRMIPPTLNFTEPNPTIEFD MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu KLPVRVAQTLTPWPDDSGRAVAGVSAFGFGGTNAHVVLAEAPQVRAAATA MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu DDHADGFVEILPLSARSQAALDALAERYESALTGGVPPADLCHTAGARRA MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu HHDHRLAVVGASRAELIGALAAYRRGEPHPGVFTGRSQSGHRSGVVFVFS MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu DEGSQWRGMAQRLYAEDQVFRTALAECDRALRRHMEISPLSELLADPSHS MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu RMDEVTIASPALFAVQVALAALWQSWGVEPAAVIGHRMGEVAAAHVAGVL MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu GLDDAAALLCGRTRLSRLASTGAVREGLDGLLANLRPDDPRIPLYSTVTG MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu DAVTGRGFGAAHWMENLHSPVRFSAAVRRLLGRGHDAFLEISAHPMLLSA MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu VQEDAADLGRSCTTLVSMRRGECGRDVLMTSLAALYASGHAVDWARVHPH MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu GSHCTAAPTYPWQRQRFWLDIDRCDTGDGAGTGGTAERTVVPAPLPAPSA MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu SAAPTVDEVLLCADQRERRELLESYLRDRVAAELGVLPPLLDVAAPLSTL MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu GIDSLTAAELRARVERDLGIVIPVAQLLNGPSVSDLAEWISTTMVGFGST MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 -------------------------------------------------- MAV_2777|M.avium_104 -------------------------------------------------- Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3604|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------- MAB_3579c|M.abscessus_ATCC_199 -------------------------------------------------- TH_4458|M.thermoresistible__bu TPEPESAGVPGRSRPPDGAVASGSGDGGRWIELLNQMPEVSDDTVDELLR MMAR_0468|M.marinum_M -------------------------------------------------- MUL_1117|M.ulcerans_Agy99 -------------------------------------------------- Rv1521|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_01234|M.leprae_Br4923 -------------------------------------------------- Mb1960|M.bovis_AF2122/97 --------------- MAV_2777|M.avium_104 --------------- Mflv_2901|M.gilvum_PYR-GCK --------------- Mvan_3604|M.vanbaalenii_PYR-1 --------------- MSMEG_4301|M.smegmatis_MC2_155 --------------- MAB_3579c|M.abscessus_ATCC_199 --------------- TH_4458|M.thermoresistible__bu QLLAAGENHDDTQLH MMAR_0468|M.marinum_M --------------- MUL_1117|M.ulcerans_Agy99 --------------- Rv1521|M.tuberculosis_H37Rv --------------- MLBr_01234|M.leprae_Br4923 ---------------