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MKHFEKDAILSGIGISRIGRRTGIPGLELTMEAVRAAVADAGLTPADVDGIATLGDTPAADVNAELQIDA PDCGTGFGTGGLLSPVMSACRAVAERRARHVIVYRTIQMLGGTVALQPEQDAPAPPLARMFDVAEGAPRP AVGPMDDITDLIAAHAYSAANWLALNCRRHMELYGTTREQLGWVALNGRRNAALNPLAVYREPMTMADYL GARPVSTPLGLLDCDVPIDGCVAVLVSTAEYARDCPHRAVRVEAIGGSDGSGGWFHRADYPKMAMSDAAA QMWSRTALKPADLEVAQLYDGFTFLTLAWLEALGICADGEAGPFVEGGARIARDGKLPLNTYGGQLSAGR MHGYWALHEGCLQLRGDAGQRQVPRRPEVGVVSVGGGPIAGCMLLTC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1629 | - | - | 100% (397) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_4731 | - | 8e-82 | 44.72% (407) | 3-ketoacyl-CoA thiolase |
| M. marinum M | MMAR_5027 | ltp2_1 | 3e-48 | 34.07% (408) | acetyl-CoA acetyltransferase (PaaJ-like), Ltp2_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3570c | ltp2 | 2e-46 | 34.07% (408) | lipid-transfer protein |
| M. gilvum PYR-GCK | Mflv_2483 | - | 4e-84 | 45.57% (406) | hypothetical protein Mflv_2483 |
| M. tuberculosis H37Rv | Rv3540c | ltp2 | 2e-46 | 34.07% (408) | lipid-transfer protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0618 | - | 2e-47 | 33.83% (402) | lipid-transfer protein |
| M. avium 104 | MAV_1865 | - | 3e-94 | 46.94% (409) | DitF protein |
| M. smegmatis MC2 155 | MSMEG_4814 | - | 2e-85 | 44.23% (407) | hypothetical protein MSMEG_4814 |
| M. thermoresistible (build 8) | TH_4141 | - | 7e-95 | 47.07% (410) | PUTATIVE DitF protein |
| M. ulcerans Agy99 | MUL_3406 | - | 0.0 | 99.46% (367) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4171 | - | 1e-85 | 46.06% (406) | hypothetical protein Mvan_4171 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1629|M.marinum_M --------------------------------------------------
MUL_3406|M.ulcerans_Agy99 --------------------------------------------------
MAV_1865|M.avium_104 --------------------------------------------------
TH_4141|M.thermoresistible__bu --------------------------------------------------
Mflv_2483|M.gilvum_PYR-GCK MSRLP---LPLLTFDNEFFWTSGADGVLRIQECGDCKSLIHPPQPVCRYC
Mvan_4171|M.vanbaalenii_PYR-1 MSRLP---LPQLTFDNEFFWKSGADGVLRIQECGDCKALIHPPQPVCRYC
MSMEG_4814|M.smegmatis_MC2_155 MSQIPGRPLPTVTALNEYFWTAGRDGVLRIQECRSCDALIHPPQPICRYC
Mb3570c|M.bovis_AF2122/97 --------------------------------------------------
Rv3540c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0618|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1629|M.marinum_M --------------------------------------------------
MUL_3406|M.ulcerans_Agy99 --------------------------------------------------
MAV_1865|M.avium_104 --------------------------------------------------
TH_4141|M.thermoresistible__bu --------------------------------------------------
Mflv_2483|M.gilvum_PYR-GCK HSHNMGPREVSGRAVLSAFTVNHRFSIPGLEAPYVVAQVAIEEDPRVRLT
Mvan_4171|M.vanbaalenii_PYR-1 HSHNMGPREVSGRAVLSAFTVNHRFSIPGLQAPYVVAQVAIEEDPRVRLT
MSMEG_4814|M.smegmatis_MC2_155 RSHDLGVRDVSGRATLAGFTVNERFGFPDMPPPYVVAEVAIVEDPRVRLT
Mb3570c|M.bovis_AF2122/97 --------------------------------------------------
Rv3540c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0618|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1629|M.marinum_M --------------------------------------------------
MUL_3406|M.ulcerans_Agy99 --------------------------------------------------
MAV_1865|M.avium_104 --------------------------------------------------
TH_4141|M.thermoresistible__bu --------------------------------------------------
Mflv_2483|M.gilvum_PYR-GCK TNIVDCDPDELELGRVVEVVFEQNEDVWLPLFRPTAEPETAALPDDEIAP
Mvan_4171|M.vanbaalenii_PYR-1 TNIIDCDPDELELGRVVEVVFEENDDVWLPLFRPTAETETAPLPEDEIAP
MSMEG_4814|M.smegmatis_MC2_155 TNIVDCDPQSLELGQPVEVSFQHIDDVWLPVFTPSADTTPTPAPVEDIAP
Mb3570c|M.bovis_AF2122/97 --------------------------------------------------
Rv3540c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0618|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1629|M.marinum_M ------------MKHFEKDAILSGIGISRIGRRTGIPGLELTMEAVRAAV
MUL_3406|M.ulcerans_Agy99 ------------------------------------------MEAVRAAV
MAV_1865|M.avium_104 ----MANVTKMTGGPFDGKAVITGAGKSQVGRRLGRTGLDLTLEAVLRAI
TH_4141|M.thermoresistible__bu ----------MSRGPFDGKAVLTGAGKSQVGRRLGRTGLDLTLEAVLRAI
Mflv_2483|M.gilvum_PYR-GCK QEFPKFVRPMLTTEKFEDAAAITGIGASKMGRRLMVSPLSLTVEACEKAI
Mvan_4171|M.vanbaalenii_PYR-1 QDFGKFVRPMLTTEKFEDAAAITGIGASRMGRRLMVSPLSLTVEACEAAI
MSMEG_4814|M.smegmatis_MC2_155 QDIGKFVRPMLTEDKFEDHSAITGIGMSRIGRRLMVPPLSLTIEAAEQAV
Mb3570c|M.bovis_AF2122/97 --------------MLSGQAAIVGIGATDFSKNSGRSELRLAAEAVLDAL
Rv3540c|M.tuberculosis_H37Rv --------------MLSGQAAIVGIGATDFSKNSGRSELRLAAEAVLDAL
MAB_0618|M.abscessus_ATCC_1997 ------------MTGLSGRSAIAGIGATDFSKKSGRSELRLAAEAVLDAL
** *:
MMAR_1629|M.marinum_M ADAGLTPADVDGIATLGDTPAAD----------VNAELQIDAPDCGTGFG
MUL_3406|M.ulcerans_Agy99 ADAGLTPADVDGIATLGDTPAAD----------VNAELQIDAPDCGTGFG
MAV_1865|M.avium_104 EDAGLAVDDVDGIASYPGPGVPDPGFSGATIQEVRNALGLRCRWYVSAME
TH_4141|M.thermoresistible__bu ADAGLDVDDIDGIASYPGPGVPDPGFSGAGIHDVRNALGLRSRWYISSME
Mflv_2483|M.gilvum_PYR-GCK ADAGLTLADIDGLSTYPAMDAMG--MGEGGCTVLEGALGIRPTWINGGMD
Mvan_4171|M.vanbaalenii_PYR-1 ADAGLTLADIDGLSTYPAMDAMG--MGEGGVTALEGALGIRPTWINGGMD
MSMEG_4814|M.smegmatis_MC2_155 ADAGLTFDDIDGLSTYPGLDIAG--MGEGGVSVLEGALGLRPTWINGGMD
Mb3570c|M.bovis_AF2122/97 ADAGLSPTDVDGLTTFTMDTNTE--------IAVARAAGIGELTFFSKIH
Rv3540c|M.tuberculosis_H37Rv ADAGLSPTDVDGLTTFTMDTNTE--------IAVARAAGIGELTFFSKIH
MAB_0618|M.abscessus_ATCC_1997 DDAGLSPSDVDGLVTFTMDSNLE--------TAVARATGIGELKFFSQIG
**** *:**: : : : :
MMAR_1629|M.marinum_M TGG--LLSPVMSACRAVAERRARHVIVYRTIQMLGGTVALQPEQDAPAPP
MUL_3406|M.ulcerans_Agy99 TGG--LLSPVMSACRAVAERRARHVIVYRTIQMLGGTVALQPEQDAPAPP
MAV_1865|M.avium_104 TAG--QIGPVIEACMAVTLGLANHVVVYRSVWES--TAAQQAGGGRASVL
TH_4141|M.thermoresistible__bu TAG--QIGPVMEACMAVSLGLANHVVVFRSVWES--TAAQQGGGGRASVL
Mflv_2483|M.gilvum_PYR-GCK TFG--PGGSLIAAVMAVATGMARHVLCFRTLWEA--TFNQLMKEGKASPP
Mvan_4171|M.vanbaalenii_PYR-1 TFG--PGGSVIAAVMAVATGMARHVLCFRTLWEA--TFNQLMKEGRVSPP
MSMEG_4814|M.smegmatis_MC2_155 TFG--PGGSVIAAMMAISAGLARHVLCFRTLWEA--TFGQLVKEGKMSPP
Mb3570c|M.bovis_AF2122/97 YGGGAACATVQHAAMAVATGVADVVVAYRAFNERSGMRFGQVQTRLTENA
Rv3540c|M.tuberculosis_H37Rv YGGGAACATVQHAAMAVATGVADVVVAYRAFNERSGMRFGQVQTRLTENA
MAB_0618|M.abscessus_ATCC_1997 YGGGAAAATVQQAALAVAAGVAEVVVAYRAFNERSEFRFGQVMTGLSSTA
* ..: * *:: * *: :*:.
MMAR_1629|M.marinum_M LARMFDVAEGAPRPAVGPMDDITDLIAAH-AYSAANWLALNCRRHMELYG
MUL_3406|M.ulcerans_Agy99 LARMFDVAEGAPRPAVGPMDDITDLIAAH-AYSAANWLALNCRRHMELYG
MAV_1865|M.avium_104 FS-------------GGKLPSHLEWVAPFGALSAANWLAMPAQRYMHDFG
TH_4141|M.thermoresistible__bu FS-------------GGKLPPHLEWVAPFGALSAANWLAMPAQRYMQEYG
Mflv_2483|M.gilvum_PYR-GCK GG-----------------ARVNSWQAPFGATSAAHTLALNAQRHFHRYG
Mvan_4171|M.vanbaalenii_PYR-1 GG-----------------TRVNSWQAPFGATSAAHTLALNAQRHFHRYG
MSMEG_4814|M.smegmatis_MC2_155 MS-----------------ARTNSWQQPYGATSAAHTLAQNAGRHFHRYG
Mb3570c|M.bovis_AF2122/97 DS----------------TGVDNSFSYPHGLSTPAAQVAMIARRYMHLSG
Rv3540c|M.tuberculosis_H37Rv DS----------------TGVDNSFSYPHGLSTPAAQVAMIARRYMHLSG
MAB_0618|M.abscessus_ATCC_1997 DS----------------RGVEYSWSYPHGLSTPAASVAMIARRYMHEYG
. . .. :.* :* . *::. *
MMAR_1629|M.marinum_M TTREQLGWVALNGRRNAALNPLAVYR-EPMTMADYLGARPVSTPLGLLDC
MUL_3406|M.ulcerans_Agy99 TTREQLGWVALNGRRNAALNPLAVYR-EPMTMADYLGARPVSTPLGLLDC
MAV_1865|M.avium_104 LTREQLGWIALNARRNAGLNPDAVYR-EPMTMDGYLGARMISEPLCLYDC
TH_4141|M.thermoresistible__bu LTREQLGAIAINARRNAGLNPDAIYR-EPMTMDDYLGARMISEPLCLYDC
Mflv_2483|M.gilvum_PYR-GCK TTKETLGWIALNQRANAALNPTAIYR-DPMTMQDYLNARPITTPFGLYDC
Mvan_4171|M.vanbaalenii_PYR-1 TTKETLGWIALNQRANAALNPTAIYR-DPMTMDDYLNARPITTPFGLYDC
MSMEG_4814|M.smegmatis_MC2_155 TTRETLGWIALNQRANAALNPTAIYR-EPLTMEDYLSARTITTPFGLYDC
Mb3570c|M.bovis_AF2122/97 ATSRDFGAVSVADRKHAANNPKAYFYGKPITIEDHQNSRWIAEPLRLLDC
Rv3540c|M.tuberculosis_H37Rv ATSRDFGAVSVADRKHAANNPKAYFYGKPITIEDHQNSRWIAEPLRLLDC
MAB_0618|M.abscessus_ATCC_1997 ATSADFGAVSVADRKHAATNPKAFFYGKPITIEDHQNSRMIADPVRLLDC
* :* ::: * :*. ** * : .*:*: .: .:* :: *. * **
MMAR_1629|M.marinum_M DVPIDGCVAVLVSTAEYARDCPHRAVRVEAIG-GSDGS----GGWFHRAD
MUL_3406|M.ulcerans_Agy99 DVPIDGCVAVLVSTAEYARDCPPRAVRVEAIG-GSDGS----GGWFHRAD
MAV_1865|M.avium_104 DVPCDGATAVIVSRRDATKGLPRYPLTVESVGPGMFER----ATWDQRSD
TH_4141|M.thermoresistible__bu DIPCDGATAVIVSRRDAAKGLPRHPLTVGSVGPGMFER----ATWDQRSD
Mflv_2483|M.gilvum_PYR-GCK DVPCDGAVAVIVSAVDAAADAPKPPVFFEAVGTQIIER----TDWDQTTL
Mvan_4171|M.vanbaalenii_PYR-1 DVPCDGAVAVVVSAVDAAVDLPKPPVYFEAVGTQIIER----TDWDQTTL
MSMEG_4814|M.smegmatis_MC2_155 DVPCDGAVAVIVSAVDAARDLPRPPIRFEAVGTQIIER----LDWDQTTL
Mb3570c|M.bovis_AF2122/97 CQETDGAVAIVVTSAARARDLKQRPVVIEAAAQGCSPDQYTMVSYYRPEL
Rv3540c|M.tuberculosis_H37Rv CQETDGAVAIVVTSAARARDLKQRPVVIEAAAQGCSPDQYTMVSYYRPEL
MAB_0618|M.abscessus_ATCC_1997 CQESDGGVAIVVTTPERAKDLKNRPVIIEAAAQGSGEDQFTMYSYYRDEL
** .*::*: : . .: . : . : :
MMAR_1629|M.marinum_M YPKMAMSDAAAQMWSRTALKPADLEVAQLYDGFTFLTLAWLEALGICADG
MUL_3406|M.ulcerans_Agy99 YPKMAMSDAAAQMWSRTALKPADLEVAQLYDGFTFLTLAWLEALGICADG
MAV_1865|M.avium_104 ITTMAAHDSGATLWQNTTLTPADVDMAQLYDGFSFLTVMWLEALGFCEHG
TH_4141|M.thermoresistible__bu LTTMAAHDSAATLWQNTTLTPKDVDMAQIYDGFSFLTVMWLEALGFCEHG
Mflv_2483|M.gilvum_PYR-GCK THEPQVLGQAAHLWTRTSLRPDDVDVAELYDGFTFNCLSWLEALGFCGIG
Mvan_4171|M.vanbaalenii_PYR-1 THEPQVLGQAAHLWTRTSLRPADVDVAELYDGFTFNCLSWLEALGFCGIG
MSMEG_4814|M.smegmatis_MC2_155 THEPQVLGQSAHMWSRTSLRPSDVDVAELYDGFTFNCLSWLEGLGFCGIG
Mb3570c|M.bovis_AF2122/97 DGLPEMGLVGRQLWAQSGLTPADVQTAVLYDHFTPFTLIQLEELGFCGKG
Rv3540c|M.tuberculosis_H37Rv DGLPEMGLVGRQLWAQSGLTPADVQTAVLYDHFTPFTLIQLEELGFCGKG
MAB_0618|M.abscessus_ATCC_1997 G-LPEMGLVGRQLWDQSGLTPNDIQTAILYDHFTPYTLLQLEELGFCGKG
. :* .: * * *:: * :** *: : ** **:* *
MMAR_1629|M.marinum_M EAGPFVEGGARIARDGKLPLNTYGGQLSAGRMHGYWALHEGCLQLRGDAG
MUL_3406|M.ulcerans_Agy99 EAGPFVEGGARIARDGKLPLNTYGGQLSARRMHGYWALHEGCLQLRGDAG
MAV_1865|M.avium_104 KVGDFIEGGERIAIDGPLPINTSGGQLSGGRLHGMGFLHEACVQMWGEGG
TH_4141|M.thermoresistible__bu RVGEFIEGGQRIALDGDLPINTSGGQLSAGRLHGMGFLHEACVQMWGEGG
Mflv_2483|M.gilvum_PYR-GCK ESKDFLDGGHAIARDGVIPLNTHGGQLSHGRTHGMGLVHEAVSQLRGEAG
Mvan_4171|M.vanbaalenii_PYR-1 EAKDFLDGGKAIARDGVIPLNTHGGQLSHGRTHGMGLIHEAVSQLRGEAG
MSMEG_4814|M.smegmatis_MC2_155 EAKDFLDGGRNIARDGIIPLNTHGGQLSHGRTHGMGLIHEAVTQLRGEAG
Mb3570c|M.bovis_AF2122/97 EAKDFIADG-AIEVGGRLPINTHGGQLGEAYIHGMNGIAEGVRQLRGTSV
Rv3540c|M.tuberculosis_H37Rv EAKDFIADG-AIEVGGRLPINTHGGQLGEAYIHGMNGIAEGVRQLRGTSV
MAB_0618|M.abscessus_ATCC_1997 EAKDFIANG-AIELGGKLPINTHGGQLGEAYIHGMNGIAEGVRQLRGTSV
. *: .* * .* :*:** ****. ** : *. *: * .
MMAR_1629|M.marinum_M QRQVPRRPEVGVVSVGGGPIAGCMLLTC--
MUL_3406|M.ulcerans_Agy99 QRQVPRRPEVGVVSVGGGPIAGCMLLTC--
MAV_1865|M.avium_104 HRQAPKTPEVVAVGVGGGPVAGSMLLSSR-
TH_4141|M.thermoresistible__bu DRQAPKTPEVVAVGVGGGPVAGSMLLSSR-
Mflv_2483|M.gilvum_PYR-GCK ERQVAD-ARVAVVSSGGLTPSGVMLLRTGA
Mvan_4171|M.vanbaalenii_PYR-1 ERQVDG-ARVAVVSSGGLTPSGALLLRTAT
MSMEG_4814|M.smegmatis_MC2_155 ERQVED-ARVAVASSGGLTPSGVLLLRRDD
Mb3570c|M.bovis_AF2122/97 N-PVAGVEHVLVTAGTGVPTSGLILG----
Rv3540c|M.tuberculosis_H37Rv N-PVAGVEHVLVTAGTGVPTSGLILG----
MAB_0618|M.abscessus_ATCC_1997 N-QVPNVEHVLVTAGTGVPTSGLILG----
. . .* ... * . :* :*