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DVTVVGSGPNGLTAAVICARAGLRVQVIEAQQTFGGGARTAADFEFPGVLHDVCSAVHPLALASPFFVEF DLAARGVRLAVPHISYANPLPDRPAAIAYRDLRQTCAELEHGPSWERLLGPLVENCDAAVDLLLGDKRSV PTALRPAMHLGLRVLAQGTPAWRGLAGEDARALFTGVAAHAISPLPSLVSAGAGLMLATLAHRVGWPIPI GGSQVIADALIADLRAHGGELTAGIEVTEPPQGVAVFDTAPTALLQVYRDTIPNRYATALRRYRFGSGVA KVDFVLNGDIPWSDDRIATAPTFHLGGTREQMAHAEAEIAAGRHADWPMVLASSPHTSDPGRVDDGGHRP FWTYAHVPAGSSVDATEAVCRVVERFAPGFRDVVVAARSVPAAAMAAHNANYVGGDIAVGANSVWRAMAG PTPRLNPWRTPIPKVYLCSAATPPGAGVHGMAGYYCARTLLRREFGIAEMPKLSL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1714 | - | - | 100% (476) | alanine rich dehydrogenase |
| M. marinum M | MMAR_2237 | - | 3e-96 | 42.24% (464) | dehydrogenase |
| M. marinum M | MMAR_1580 | - | 2e-94 | 40.60% (463) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3021 | - | 0.0 | 78.27% (474) | alanine rich dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4235 | - | 0.0 | 69.68% (475) | hypothetical protein Mflv_4235 |
| M. tuberculosis H37Rv | Rv2997 | - | 0.0 | 78.48% (474) | alanine rich dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4734 | - | 3e-97 | 40.30% (464) | dehydrogenase |
| M. avium 104 | MAV_3848 | - | 0.0 | 77.68% (475) | P49 protein |
| M. smegmatis MC2 155 | MSMEG_2377 | - | 0.0 | 72.01% (468) | P49 protein |
| M. thermoresistible (build 8) | TH_2036 | - | 0.0 | 72.38% (467) | POSSIBLE ALANINE RICH DEHYDROGENASE |
| M. ulcerans Agy99 | MUL_1826 | - | 3e-96 | 42.80% (465) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2127 | - | 0.0 | 71.16% (475) | hypothetical protein Mvan_2127 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3021|M.bovis_AF2122/97 ------MDVTVVGSGPNGLATAVICARAGLNVQVVEAQATFGGGARSAAD
Rv2997|M.tuberculosis_H37Rv ------MDVTVVGSGPNGLATAVICARAGLNVQVVEAQATFGGGARSAAD
MMAR_1714|M.marinum_M ------MDVTVVGSGPNGLTAAVICARAGLRVQVIEAQQTFGGGARTAAD
MAV_3848|M.avium_104 ------MDVTIVGSGPNGLTAALICARAGLKVQVVEAQPTFGGGARTAAD
Mflv_4235|M.gilvum_PYR-GCK MGSNGQVELTVVGSGPNGLAAAVICARAGVSVRVVEAQPTAGGGARTLPD
Mvan_2127|M.vanbaalenii_PYR-1 MGSNVQVELTVVGSGPNGLAAAVICARAGLSVRVVEAQPTPGGGARTLPD
MSMEG_2377|M.smegmatis_MC2_155 ------MDVTVVGSGPNGLTAAVICARAGLAVRVIEAQTTPGGGARTLPD
TH_2036|M.thermoresistible__bu ------MDVTVVGSGPNGLAAAVTCARAGLSVQVLEAQPTAGGGARTTAD
MAB_4734|M.abscessus_ATCC_1997 -----MSTAVIVGGGPNGLTAAILLAQQGVHVTVLEAADSVGGGVRSGA-
MUL_1826|M.ulcerans_Agy99 -----MTKAVVVGAGPNGLAAAIQLARHGVEVQVLEAHDTIGGGARSGE-
.:**.*****::*: *: *: * *:** : ***.*:
Mb3021|M.bovis_AF2122/97 FEFPEVLHDVCSAVHPLALASPFFAEFDLPARGVTLTVPDIAYANPLPGR
Rv2997|M.tuberculosis_H37Rv FEFPEVLHDVCSAVHPLALASPFFAEFDLPARGVTLTVPDIAYANPLPGR
MMAR_1714|M.marinum_M FEFPGVLHDVCSAVHPLALASPFFVEFDLAARGVRLAVPHISYANPLPDR
MAV_3848|M.avium_104 PDSAGVLHDICSAVHPLALASPFFAEFDLPARGVQLAVPEISYANPLPGR
Mflv_4235|M.gilvum_PYR-GCK PEFSGVSHDICSAVHPLALASPFFAAFDLRARGVTLEVPEVSYGNPLPGR
Mvan_2127|M.vanbaalenii_PYR-1 PEFSGVSHDICSAVHPLALASPFFAEFDLQARGVTLAVPEVSYGNPLPGR
MSMEG_2377|M.smegmatis_MC2_155 PEFGGVSHDICSAVHPLALASPFFSAYDLTAHGVRLAVPEIAYANPLVER
TH_2036|M.thermoresistible__bu PEFEGIVHDVCSAVHPMALASPFMAEFDLPARGVRLQVPAISYANPLLDR
MAB_4734|M.abscessus_ATCC_1997 ATGPGLIHDYCSAIHPMAVGSPVLAGLDLEKHGLQWLWPEVDCAHPLDDG
MUL_1826|M.ulcerans_Agy99 LTVPGVIHDHCSAFHPLGVGSPFWNEIDLQSYGLTWNWPEVDCAHPLDDG
: ** ***.**:.:.**. ** *: * : .:**
Mb3021|M.bovis_AF2122/97 PAAIAYHDLAHTSAKLD-DGASWRRLLGPLVAHSETVVEFMLSDKRSLPT
Rv2997|M.tuberculosis_H37Rv PAAIAYHDLAHTCAKLD-DGASWRRLLGPLVAHSETVVEFMLSDKRSLPT
MMAR_1714|M.marinum_M PAAIAYRDLRQTCAELE-HGPSWERLLGPLVENCDAAVDLLLGDKRSVPT
MAV_3848|M.avium_104 PAAIAYRDLDRTCAELE-HGASFRRLLGPLVARSEDVVALLLGDKRSLPN
Mflv_4235|M.gilvum_PYR-GCK RAAIGYLDIDRTCAELE-DGEPWRRLLGPLAADCDGVVGLLLGDKRSIPP
Mvan_2127|M.vanbaalenii_PYR-1 PAAVGYRDIERTCAELD-DGASWRRLLGPLADDCDGVVGLLLGDKRSIPP
MSMEG_2377|M.smegmatis_MC2_155 PAAIGYRDIDRTCAELD-DGRSWRRLLGPLADDCDGVVGLMLGDKRSLPP
TH_2036|M.thermoresistible__bu PAAVAYRDLDRTCAELV-NGHSWRRLFGPLTARDDGVLDLVMGDKRSIPS
MAB_4734|M.abscessus_ATCC_1997 SCGVLYRDVAATANGLGRDGRRWRALFERPARNFDLLTADIMGPLLRIPR
MUL_1826|M.ulcerans_Agy99 TAGVLHQSIERTAAGMGPDGKRWRCAVGDLAAGFDELAGDLLRPVLGVPR
..: : .: *. : .* :. . . : :: :*
Mb3021|M.bovis_AF2122/97 ALGSVLRLGLRMLAQGTPAWRSLAGEDARALFTGVAAHAISPLPSLVSAG
Rv2997|M.tuberculosis_H37Rv ALGSVLRLGLRMLAQGTPAWRSLAGEDARALFTGVAAHAISPLPSLVSAG
MMAR_1714|M.marinum_M ALRPAMHLGLRVLAQGTPAWRGLAGEDARALFTGVAAHAISPLPSLVSAG
MAV_3848|M.avium_104 SPTSALRLGLRMLAQGTPAWGTLAGEDARALFTGVAAHIISRMPSLTAAG
Mflv_4235|M.gilvum_PYR-GCK SIPAALRVAPRLLAQGTPAWGTLLGEDARALFTGVAAHTISRMPSLVASG
Mvan_2127|M.vanbaalenii_PYR-1 SIPAAVRVAPRLLAQGSPAWGTLAGEDARALFTGVAAHTISRMPSLVSAG
MSMEG_2377|M.smegmatis_MC2_155 SIPAALRVAPRMLGQGTALWRLLRGDDARALFSGVAAHTISPMPSLVSAG
TH_2036|M.thermoresistible__bu DPIAALQLGMRMLAQGSAAWGSLSGSDARALFSGVAGHAISRMPSLISAG
MAB_4734|M.abscessus_ATCC_1997 HPLALTRFGVPTVLPAAATAQLFRTRQARALFGGIAAHAFRPLHYPMTSA
MUL_1826|M.ulcerans_Agy99 HPLRPAAFGPRAALPATMMARWFRTEQARALFGGAAAHVYTRLDRPLTAS
.. .: : :***** * *.* : ::.
Mb3021|M.bovis_AF2122/97 AGLMLATLAHSVGWPIPVGGTQAIADALIADLRAHGGRLAAGVEITE---
Rv2997|M.tuberculosis_H37Rv AGLMLATLAHSVGWPIPVGGTQAIADALIADLRAHGGRLAAGVEITE---
MMAR_1714|M.marinum_M AGLMLATLAHRVGWPIPIGGSQVIADALIADLRAHGGELTAGIEVTE---
MAV_3848|M.avium_104 AGLMLATLAHSVGWPIPVGGSQAITDALIADLRAHGGELTAGAEVTK---
Mflv_4235|M.gilvum_PYR-GCK AGLMLSTLAHAVGWPIPVGGSQAIPDALIADLRAHGGELVVGEEVST---
Mvan_2127|M.vanbaalenii_PYR-1 AGLMLATLGHTVGWPVPSGGSQAIPDALLADLQAHGGELVLGEEVTS---
MSMEG_2377|M.smegmatis_MC2_155 AGLMLATLAHAVGWPIPIGGSQAIPDALIADLRAHGGELVLGEEVTE---
TH_2036|M.thermoresistible__bu AGLLLATLAHTVGWPIPIGGSQRITDALIADLTAHGGELRVGEPVTR---
MAB_4734|M.abscessus_ATCC_1997 IGLGIITAGHRHGWPVAAGGSQSITDALSSLLAQFGGRIETGVHVTSFTQ
MUL_1826|M.ulcerans_Agy99 LGLMILASGHRYGWPVAQGGSGSITAALGAALDALGGVVATGITVTSRRD
** : : .* ***:. **: *. ** : * ** : * ::
Mb3021|M.bovis_AF2122/97 -PQRSVVVFDTAPTALLRVYRDKLPHRYAKALRRYRFRAGIAKVDFVLSD
Rv2997|M.tuberculosis_H37Rv -PQRSVVVFDTAPTALLRVYRDKLPHRYAKALRRYRFRAGIAKVDFVLSD
MMAR_1714|M.marinum_M -PPQGVAVFDTAPTALLQVYRDTIPNRYATALRRYRFGSGVAKVDFVLNG
MAV_3848|M.avium_104 -PPGGVVAYDTAPTALLRIYGDALPPRYAKALQRYTFGPGVAKVDFVLSD
Mflv_4235|M.gilvum_PYR-GCK -PPSGVVLYDTAPTALLDIYGDRLPSRYARTLRRYRYGPGVAKVDFVLSG
Mvan_2127|M.vanbaalenii_PYR-1 -PPSGVVLYDTAPTALLRIYGDRLPPGYAKTLRRYRYGPGVAKVDFVLSG
MSMEG_2377|M.smegmatis_MC2_155 -PPSGVVVYDTAPTALLSIYRDAVPPRYAKALRNYTYGSGVAKVDFVLSG
TH_2036|M.thermoresistible__bu -PPEGVVIYDTAPTALLDIYGDALPARYARALRRYRFGPGVAKVDFVLSD
MAB_4734|M.abscessus_ATCC_1997 LPTADVTLFDLSPTQVADILRDHLPTSVARGLSRFRYGPGAFKVDFAIED
MUL_1826|M.ulcerans_Agy99 IPDADIVMLDLSPANVLTLYGDEMPARIKRSYRRYREGSSAFKVDFAIEG
* .:. * :*: : : * :* .: .. ****.:..
Mb3021|M.bovis_AF2122/97 EIPWSDPRLRRAATLHLGGTRDQMARAEADVAAGRHADWPMVLAACPHVA
Rv2997|M.tuberculosis_H37Rv EIPWSDPRLRRAATLHLGGTRDQMARAEADVAAGRHADWPMVLAACPHVA
MMAR_1714|M.marinum_M DIPWSDDRIATAPTFHLGGTREQMAHAEAEIAAGRHADWPMVLASSPHTS
MAV_3848|M.avium_104 EIPWSDPRLRQAPTLHLGGTREQMARAEADIAAGRHAQWPMVLAASPHVA
Mflv_4235|M.gilvum_PYR-GCK EIPWRDKRLASAPTLHMGGDRATMALAEKDIAEGRHAQWPMVLASLPHLA
Mvan_2127|M.vanbaalenii_PYR-1 EIPWRDPRLANAPTLHLGGDRATMARAEKDVAAGRHAEWPMVLASLPHLA
MSMEG_2377|M.smegmatis_MC2_155 EIPWRDPRLAQSPTLHLGGSREQMALAESEVARGRHAEWPMVLAASPHIA
TH_2036|M.thermoresistible__bu EIPWQDPRLANAPTLHLGGSREQMAHAEREIFADRHAEWPMTLASLPHLV
MAB_4734|M.abscessus_ATCC_1997 GVPWTNPDAGRAGTVHLGGTFAEVASTERAVHAGRMPERPFVLVGQQYLA
MUL_1826|M.ulcerans_Agy99 DIPWTNPDCRRAGTVHLGGTFAEIADTERQRAQGRMVQRPFVLIGQQYLA
:** : : *.*:** :* :* .* : *:.* . :
Mb3021|M.bovis_AF2122/97 DPGRIDETGRRPFWTYAHVPSGSTLDATETVTSVLERFAPGFRDIVVAAR
Rv2997|M.tuberculosis_H37Rv DPGRIDETGRRPFWTYAHVPSGSTLDATETVTSVLERFAPGFRDIVVAAR
MMAR_1714|M.marinum_M DPGRVDDGGHRPFWTYAHVPAGSSVDATEAVCRVVERFAPGFRDVVVAAR
MAV_3848|M.avium_104 DPGRIDAAGRRPFWTYAHVPAGSTLDATEAVTAVVERFAPGFHDVVVAAR
Mflv_4235|M.gilvum_PYR-GCK DPGRIDAAGRRPLWTYAHVPAGSTVDMAETITGVFERFAPGFRDLVVGVR
Mvan_2127|M.vanbaalenii_PYR-1 DPGRVDPQGRRPLWTYAHVPAGSTVDMAEAVTEVIERFAPGFRDVVVGVR
MSMEG_2377|M.smegmatis_MC2_155 DPGRIDARGRRPLWTYAHVPSGSPVDMADTVTSILERFAPGFRDLVVAVR
TH_2036|M.thermoresistible__bu DPGRVDGQGRRPLWSYVHVPAHSPVDQTESVIKIFERFAPGFRDIVVAAR
MAB_4734|M.abscessus_ATCC_1997 DPGRSNGN-IHPLWTYAHVPHGFTGDATQALIDQIERFAPGFRDRIVATA
MUL_1826|M.ulcerans_Agy99 DPSRSAGN-INPIWAYAHVPFGYAGDATAAVIDQIERFAPGFRDRITATV
**.* .*:*:*.*** . * : :: .*******:* :...
Mb3021|M.bovis_AF2122/97 AVPAARMADHNANYVGGDITVGANSTWRAIAGPTPRLNPWRTPIPKVYLC
Rv2997|M.tuberculosis_H37Rv AVPAARMADHNANYVGGDITVGANSTWRAIAGPTPRLNPWRTPIPKVYLC
MMAR_1714|M.marinum_M SVPAAAMAAHNANYVGGDIAVGANSVWRAMAGPTPRLNPWRTPIPKVYLC
MAV_3848|M.avium_104 AIPAARLCDHNANYVGGDIGIGGNSAWRAIAGPTPRVNPWSTPIPKVYLC
Mflv_4235|M.gilvum_PYR-GCK SVPAARLADHNANLVGGDIGVGGNNMFSALTGPALRWNPWATPIPRTYLC
Mvan_2127|M.vanbaalenii_PYR-1 SVPAARLSAHNANLVGGDIGVGGNNMVSALTGPALRWNPWSTPIPKAYLC
MSMEG_2377|M.smegmatis_MC2_155 SVPASQMSHHNANLIGGDIGVGGNNMISALTGPTPRVNPWTTPIPKAYLC
TH_2036|M.thermoresistible__bu CVPAARLADDNANYVGGDIAVGGNDTWRALAGPTPRLNPWSTPIPRAYQC
MAB_4734|M.abscessus_ATCC_1997 VRSTTDMTVYNPNYVGGDIVTGAKDIRQLVFGPRTTAHPYRLGIPGMYIC
MUL_1826|M.ulcerans_Agy99 SKSTAELQAYNRNFIGGDIIGGANDGLQVIFRPRIALDPYAIGVPGVYLC
.:: : * * :**** *.:. : * .*: :* * *
Mb3021|M.bovis_AF2122/97 SAATPPGAGVHGMCGWYAARTLLRTEFGITRMPPLGHELRP---------
Rv2997|M.tuberculosis_H37Rv SAATPPGAGVHGMCGWYAARTLLRTEFGITRMPPLGHELRP---------
MMAR_1714|M.marinum_M SAATPPGAGVHGMAGYYCARTLLRREFGIAEMPKLSL-------------
MAV_3848|M.avium_104 SAATPPGGGVHGMAGYYAARTLLRREFGLD-MPRLAP-------------
Mflv_4235|M.gilvum_PYR-GCK SSATPPGGGVHGMAGYYAARTVLRREFGIREMPPLAP-------------
Mvan_2127|M.vanbaalenii_PYR-1 SSATPPGGGVHGMAGFYAARTVLRREFGIRELPPLAP-------------
MSMEG_2377|M.smegmatis_MC2_155 SSATPPGSGVHGMSGFYAARTVLRREFGLG-LPALR--------------
TH_2036|M.thermoresistible__bu SSATPPGPGVHGLAGYYAARTVLRREFGXXXGTATSSRTPTTYSARRSEF
MAB_4734|M.abscessus_ATCC_1997 SAATPPGPGAHGMCGAHAAAEALRHLRASI--------------------
MUL_1826|M.ulcerans_Agy99 SQSAPPGAGIHGLCGYHAAESALQGLRKRR--------------------
* ::*** * **:.* :.* *:
Mb3021|M.bovis_AF2122/97 -----------------------------------------
Rv2997|M.tuberculosis_H37Rv -----------------------------------------
MMAR_1714|M.marinum_M -----------------------------------------
MAV_3848|M.avium_104 -----------------------------------------
Mflv_4235|M.gilvum_PYR-GCK -----------------------------------------
Mvan_2127|M.vanbaalenii_PYR-1 -----------------------------------------
MSMEG_2377|M.smegmatis_MC2_155 -----------------------------------------
TH_2036|M.thermoresistible__bu GASYRRRFFALASFLRRGLLIAPTNSLVCNIEGRDRRELDR
MAB_4734|M.abscessus_ATCC_1997 -----------------------------------------
MUL_1826|M.ulcerans_Agy99 -----------------------------------------