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TTTTLAERTVTVDGKPIFFAEAGSGPTVVLLHGGGPGATGLSNYARNIDLLAQRFRLIIPDMPGYGRSSK GVDQSDPFGYLASAIRGLLDELRIPSAHLVGNSYGGAAALRLALDSPHRVDRLVLMGPGGIGTTRSAPTA GLKTLLSYYAGDGPSRAKLAHLIRTYLVYEGDSVPDELIDLRYQASIDPAVIADPPLRRPNGLRTLWRMD LTRDRRLRQLPTPTLVLWGRDDKINRPAGGPKLLNLMPNAELVMTSRTGHWMQWERAELFNQLVAEFLSQ SSAFAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1502 | - | - | 100% (287) | hypothetical protein MMAR_1502 |
| M. marinum M | MMAR_5064 | bphD | 6e-46 | 39.22% (283) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. marinum M | MMAR_4771 | - | 9e-26 | 31.65% (278) | hypothetical protein MMAR_4771 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 4e-45 | 38.28% (290) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_1464 | - | 2e-41 | 37.08% (267) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 4e-45 | 38.28% (290) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_02297 | - | 1e-07 | 26.76% (284) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4366c | - | 6e-50 | 39.73% (292) | putative hydrolase, alpha/beta fold |
| M. avium 104 | MAV_2517 | - | 1e-130 | 76.47% (289) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_6037 | - | 3e-41 | 36.70% (267) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. thermoresistible (build 8) | TH_1741 | - | 2e-43 | 39.34% (272) | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD |
| M. ulcerans Agy99 | MUL_4140 | bphD | 6e-46 | 39.22% (283) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_0592 | - | 1e-124 | 78.03% (264) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1502|M.marinum_M ------------MTTTTLAERTVTVDGKPIF---------FAEAG--SGP
MAV_2517|M.avium_104 ------------MTTSNMADHAVTVNGKSIF---------FAEKG--TGA
Mvan_0592|M.vanbaalenii_PYR-1 ------------MTRSD-SEYRVRVGTAEIS---------VTDTGG-DGA
Mflv_1464|M.gilvum_PYR-GCK -----MTSFAAEAAQQQEITFESTSRYAQVR---EDMRLHYHEAGVGNPK
TH_1741|M.thermoresistible__bu -----MTSYIQEAENQVEITFESTSRYAEVKAGDRDMRLHYHEAGIGHAQ
MSMEG_6037|M.smegmatis_MC2_155 -----------MVTATQEITFESTSRFADVQAGELAMRLHYHEAGDPSAQ
Mb3600c|M.bovis_AF2122/97 ------------MTATEELTFESTSRFAEVD-VDGPLKLHYHEAGVGNDQ
Rv3569c|M.tuberculosis_H37Rv ------------MTATEELTFESTSRFAEVD-VDGPLKLHYHEAGVGNDQ
MUL_4140|M.ulcerans_Agy99 --------MTVTQSKTAEHTFESTSRYAEVD-VDGPLKLHYHEAGVGNDQ
MAB_4366c|M.abscessus_ATCC_199 ------------MTIHTHLQSISTT-LGEIA------VHDVPAAGGADAP
MLBr_02297|M.leprae_Br4923 MAMSNPSVTRIAGPWHHLDVHANGIRFHVVEAVPTQPAGQDCAPSATARP
: .
MMAR_1502|M.marinum_M TVVLLHGGGPGATGLSNYARNIDLLAQRFRLIIPDMPGYGRSSKGV----
MAV_2517|M.avium_104 PVLLLHGGGPGASGVSNYSRNIDPLAEKFRVIVPDMPGYGRSAKGV----
Mvan_0592|M.vanbaalenii_PYR-1 PVVLLHGGGPGASGISNYSRNIGALAASYRVIVPDMPGYGRSTKYV----
Mflv_1464|M.gilvum_PYR-GCK TVVLLHGGGPGASSWSNFGRNIPVLAKHFHVLAVDQPGYGHSDKHT----
TH_1741|M.thermoresistible__bu KVVLLHGGGPGASSWSNFGRNIAVLARHFHVIAVDQPGYGHSDKHT----
MSMEG_6037|M.smegmatis_MC2_155 TIVLLHGGGPGAASWSNFGRNIAVLAEHFHVLAVDQPGYGLSDKHT----
Mb3600c|M.bovis_AF2122/97 TVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRA----
Rv3569c|M.tuberculosis_H37Rv TVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRA----
MUL_4140|M.ulcerans_Agy99 TVVLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRA----
MAB_4366c|M.abscessus_ATCC_199 TLVMLHGGGPGASGLSNYEQNIPALSRTFRILLPDQPGFGGSYRPTGADL
MLBr_02297|M.leprae_Br4923 LVMLLHGFG---SFWWSWRHQLRGLT-EARLVAVDLRGYGGSDKPP----
:::*** * : .: ::: *: ::: * *:* * :
MMAR_1502|M.marinum_M DQSDPFGYLASAIRGLLDELRIP-SAHLVGNSYGGAAALRLALDSPHRVD
MAV_2517|M.avium_104 DQSDPFGYLADTMRGLLDELGID-SAHLVGNSYGGSCALRLALDNPRRVG
Mvan_0592|M.vanbaalenii_PYR-1 DHSDPFGYLADSIRGMLDEMGVQ-QAHLVGNSYGGAAALRLALDTPHRAD
Mflv_1464|M.gilvum_PYR-GCK EHEQYNRYSATALLNLFDHLGIE-KAALVGNSLGGGTAVRFALDNGKRAG
TH_1741|M.thermoresistible__bu EHEQYNRYSATALLALFDHLGIE-RADLVGNSLGGGTAVRFALDHPKRAG
MSMEG_6037|M.smegmatis_MC2_155 EHEQYNRYSAKAVRGLLDHLGVEGRVPLLGNSLGGGTAVRFALDYPDRAG
Mb3600c|M.bovis_AF2122/97 EHGQFNRYAAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAG
Rv3569c|M.tuberculosis_H37Rv EHGQFNRYAAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAG
MUL_4140|M.ulcerans_Agy99 EHGQFNHYAARALKELFDQLGLG-RVLLVGNSLGGGTAVRFALDYPDRAG
MAB_4366c|M.abscessus_ATCC_199 DERSITEITVDALFQVLDDLAVG-SFHLLGNSLGGAAAIRMAQLRPERVT
MLBr_02297|M.leprae_Br4923 -RGYDGWTLAGDTAGLIRALGHS-SATLVGHAEGGLACWATALLHPRLVR
. . :: : *:*:: ** . * .
MMAR_1502|M.marinum_M RLVLMG---PGGIGTTRSAP----TAGLKTLLSYYAGDGPSR-------A
MAV_2517|M.avium_104 KLVLMG---PGGIGTTRGLP----TAGLNSLLAYYGGRGPSR-------D
Mvan_0592|M.vanbaalenii_PYR-1 KLVLMG---PGGIGTTRGLP----TPGLKSLLGYYAGEGPSR-------E
Mflv_1464|M.gilvum_PYR-GCK KLVLMG---PGGLSVNLFSPDP--TEGVKLLGRFA--AEPTR-------E
TH_1741|M.thermoresistible__bu RLVLMG---PGGLSVNMFAPDP--TEGVKLLARFN--AEPTR-------E
MSMEG_6037|M.smegmatis_MC2_155 KLVLMG---PGGLSVNLFAPDP--TEGVKALAKFN--VEPTR-------E
Mb3600c|M.bovis_AF2122/97 RLVLMG---PGGLSINLFAPDP--TEGVKRLSKFS--VAPTR-------E
Rv3569c|M.tuberculosis_H37Rv RLVLMG---PGGLSINLFAPDP--TEGVKRLSKFS--VAPTR-------E
MUL_4140|M.ulcerans_Agy99 RLVLMG---PGGLSINLFAPDP--TEGVKRLGKFS--VAPTR-------E
MAB_4366c|M.abscessus_ATCC_199 RLVLMA---PGGGWL-PFGPTP--TEGQKEMFRYFNGEGPTE-------K
MLBr_02297|M.leprae_Br4923 AIALINSPHPAALRRSMLTHRNQGYALLPTLLRYQLPIWPERLLTRNNAA
:.*: *.. : : * .
MMAR_1502|M.marinum_M KLAHLIRTYLVYEGDSVPDELIDLRYQASIDPAVIADPPLRRPNG---LR
MAV_2517|M.avium_104 KLEAFIRNYLVYDGASVPDELIDLRYQASVDPEVVADPPLRRPSGPMALR
Mvan_0592|M.vanbaalenii_PYR-1 KLATFIRSYLVYDGPSVPDELIDLRYQASLDPQVVADPPLRRPSG---LR
Mflv_1464|M.gilvum_PYR-GCK NIEKFLR-IMVFDQAMITPELVEERFQIASTPESLAAT---KAMGKSFAG
TH_1741|M.thermoresistible__bu NLEAFLR-IMVYDQSLITEELIDERFAIAATPESLAAT---RAMGKSFMG
MSMEG_6037|M.smegmatis_MC2_155 NLEAFLR-IMVFDQKLITPELVEERFAIASTPESLAAT---RAMGKSFAG
Mb3600c|M.bovis_AF2122/97 NLEAFLR-VMVYDKNLITPELVDQRFALASTPESLTAT---RAMGKSFAG
Rv3569c|M.tuberculosis_H37Rv NLEAFLR-VMVYDKNLITPELVDQRFALASTPESLTAT---RAMGKSFAG
MUL_4140|M.ulcerans_Agy99 NLEAFLR-VMVYDQKLITPELVDQRFELARTPESLAAT---RAMGKSFAA
MAB_4366c|M.abscessus_ATCC_199 KMAAFIR-AMVFDHKQFGRDVVSRRYQASLDEGHIEFY---HHYNAAFAK
MLBr_02297|M.leprae_Br4923 EIERLVRSRSSAKWQACEDFAVTIDHLRIAIQIPAAAHCALEYQRWAVRS
:: ::* . : . .
MMAR_1502|M.marinum_M TLWRMDLTRDRRLRQ-LPTPTLVLWGRDDKINRPAGGPKLLNLMPNAELV
MAV_2517|M.avium_104 TLWRMDLARDRRLKR-LRTPTLVLWGRDDKVNRPAGGPMLLNLMPNAELV
Mvan_0592|M.vanbaalenii_PYR-1 TLWRMDLTRDKRLRR-LPNPTLVLWGRDDKVNRPAGGPMLLNMMPNAELV
Mflv_1464|M.gilvum_PYR-GCK ADFELGMMW-RDVYK-LRQRVLLIWGREDRVNPLDGALVALKQIPRVQLH
TH_1741|M.thermoresistible__bu PDFELGMMW-RDAYK-LRQRVLLIWGREDRVNPLDGALVALKQIPRVQLH
MSMEG_6037|M.smegmatis_MC2_155 ADFELGMMW-REVYK-LRQPVLLIWGREDRVNPLDGALVAVKQIPRVQLH
Mb3600c|M.bovis_AF2122/97 ADFEAGMMW-REVYR-LRQPVLLIWGREDRVNPLDGALVALKTIPRAQLH
Rv3569c|M.tuberculosis_H37Rv ADFEAGMMW-REVYR-LRQPVLLIWGREDRVNPLDGALVALKTIPRAQLH
MUL_4140|M.ulcerans_Agy99 ADFELGMMW-REVYK-LRQPVLLIWGREDRVNPLDGALVALKTIPRAQLH
MAB_4366c|M.abscessus_ATCC_199 RN-GMDPLW-RDLHT-ITAPTLLLWGRDDRTITLEGAQMMLKHISDVQLH
MLBr_02297|M.leprae_Br4923 QLRNEGRKFMKSMSRPFSVPLLHVRGDADPYLLADSVDRTRRYAPHGRYV
. : : * : * * . . . .
MMAR_1502|M.marinum_M MTSRTGHWMQWERAELFNQLVAEFLSQSSAFAS-
MAV_2517|M.avium_104 MTSRTGHWVQWERADLFNKLVTEFLHNTSVFAQ-
Mvan_0592|M.vanbaalenii_PYR-1 MTSHTGHWMQWERAELFNELVSDFLSPDTRLASS
Mflv_1464|M.gilvum_PYR-GCK VFGQCGHWAQLEKFDEFNKLTIDFLTN-------
TH_1741|M.thermoresistible__bu VFGQCGHWAQVEKFDEFNRLTIDFLEDGAKEAKS
MSMEG_6037|M.smegmatis_MC2_155 VFGQCGHWAQVEKFDEFNKLTIDFLGG-------
Mb3600c|M.bovis_AF2122/97 VFGQCGHWVQVEKFDEFNKLTIEFLGGGR-----
Rv3569c|M.tuberculosis_H37Rv VFGQCGHWVQVEKFDEFNKLTIEFLGGGR-----
MUL_4140|M.ulcerans_Agy99 VFGQCGHWAQVEKFDEFNRLTIDFLGGAR-----
MAB_4366c|M.abscessus_ATCC_199 VFGRCGHWVQLERQAEFDRLVADFLGEPA-----
MLBr_02297|M.leprae_Br4923 SVSDAGHFSHEEAPEEINRYLTRFLKQVHGPRLS
. **: : * ::. **