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SSVDVIVPVGAALVIAGLAWYFFAPRRAHAASLSEGVQRILVTIRGGYSPNVVQVRQGAPVEIEFDRQES GDCSSRVVFPDLHLSAALPAHQRTTVRFTPQQAGSFGFFCSMNMINGTLVVTPDGQAAGSAEPEQPNASI GYAATNSGDEPAAAEIEAAQAQERRAEITDLSRRVAFGAVLSAPVLYAVMAQPLGAGWVPAVLLHHWLQL ALITPVMFYVGWPIHRTGWLALAHRSADMNSLITLGTFAAYGYSLLVTAASTALPAELQDVYYEAVGVIL TLIMLGRLLEARAKAGTGEAIRALLGLQARTARVIRNGTQAEIPVDEVVVGDDILVRPGEKIAVDATVVS GQSTVDESMVTGESMPVTKHTGDTVIGATVNTTGSLRIRAAKVGADTMLAQIIGMVQQAQASRAPIQRLA DAISAYFVPVVIAIAIATFAVWFVAGPTPELTQALVSAVAVLIIACPCALGLATPLSIMVGTGKGARAGI LIRSAEALETAHKLDTIVLDKTGTVTAGRPALTDVEVTGTLQQNELLALVAAAEANSEHPVATAVLAGSR DRGIDHSAADDFASITGKGVRATVAGRTVLVGTATLLAENNVTTSELERIGADLAAKGKTPILAAVDGRP AGVLAVADTVKDDSMAAIAALGKLGLQVVMITGDNARTAKAIARQVGVSRVLAEVLPEHKAGEIRRLQAE GRTVGMVGDGINDAPALAQADVGLAIGTGTDVAIEAADITLISGSLAGVVTAIQLSRATMRNIRENLFFA LIYNAIGIPLAAGVLYPTLGLRLSPMIAAAAMALSSLSVVGNANRLRRYRVEPLPPAEAPTTEPRVETVT AQSESGDR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_1448 | - | - | 100% (849) | zinc cation transport ATPase |
M. marinum M | MMAR_2536 | - | e-171 | 50.15% (680) | metal cation transporter p-type ATPase |
M. marinum M | MMAR_4876 | ctpV | e-168 | 52.93% (614) | metal cation transporter p-type ATPase, CtpV |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0994 | ctpV | 1e-166 | 52.12% (614) | metal cation transporter P-type ATPase CtpV |
M. gilvum PYR-GCK | Mflv_2849 | - | 1e-165 | 46.43% (715) | heavy metal translocating P-type ATPase |
M. tuberculosis H37Rv | Rv0969 | ctpV | 1e-165 | 51.95% (614) | metal cation transporter P-type ATPase CtpV |
M. leprae Br4923 | MLBr_02000 | ctpB | 1e-133 | 39.28% (751) | cation-transporting ATPase |
M. abscessus ATCC 19977 | MAB_3984c | - | 1e-141 | 44.21% (656) | putative metal transporter ATPase |
M. avium 104 | MAV_5246 | - | 1e-146 | 40.67% (772) | copper-translocating P-type ATPase |
M. smegmatis MC2 155 | MSMEG_5014 | - | 1e-162 | 46.37% (716) | copper-translocating P-type ATPase |
M. thermoresistible (build 8) | TH_4361 | - | 1e-161 | 46.92% (697) | PUTATIVE heavy metal translocating P-type ATPase |
M. ulcerans Agy99 | MUL_0423 | ctpV | 1e-166 | 52.44% (614) | metal cation transporter p-type ATPase, CtpV |
M. vanbaalenii PYR-1 | Mvan_4449 | - | 1e-161 | 46.61% (693) | heavy metal translocating P-type ATPase |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_5014|M.smegmatis_MC2_155 ---------------------------------MTTATGHVELQIGG--- Mvan_4449|M.vanbaalenii_PYR-1 -------------------------------------MNTIELSIGG--- Mflv_2849|M.gilvum_PYR-GCK -----------------------------MTTSIPVSGPSIELRIGG--- MAV_5246|M.avium_104 ------------------MSTPPRHIDEGTFPDHTASTARIELEITG--- TH_4361|M.thermoresistible__bu --------------------------------MNTGGMNTVTLTVGG--- MAB_3984c|M.abscessus_ATCC_199 ------------------------------METTNTGMETTDLRLHG--- MLBr_02000|M.leprae_Br4923 ----------------------MTASLVEDTNNNHESVRRIQLDVAG--- Mb0994|M.bovis_AF2122/97 --------------------MRVCVTGFNVDAVRAVAIEETVSQVTG--- Rv0969|M.tuberculosis_H37Rv --------------------MRVCVTGFNVDAVRAVAIEETVSQVTG--- MUL_0423|M.ulcerans_Agy99 --------------------MRVHANGFAIDATRAAAIEESVGRVGG--- MMAR_1448|M.marinum_M MSSVDVIVPVGAALVIAGLAWYFFAPRRAHAASLSEGVQRILVTIRGGYS : * MSMEG_5014|M.smegmatis_MC2_155 --MTCASCAARIERKLNKLD----GVTASVNYATEKASVEVAGEVSPETL Mvan_4449|M.vanbaalenii_PYR-1 --MTCASCAARVEKKLNKLD----GVTATVNFATEKARVAFGDEVSPGQL Mflv_2849|M.gilvum_PYR-GCK --MTCASCANRIERKLNKID----GVAATVNYATEKATVTVPDGYDPALL MAV_5246|M.avium_104 --MTCASCAARIEKKLNKLD----GVTATVNYATEKAAVSAPASYDPQTL TH_4361|M.thermoresistible__bu --MTCASCAARVEKRLNRID----GVVATVNFATEQATVRYPDHVDPADL MAB_3984c|M.abscessus_ATCC_199 --MTCASCASRVEKGLNKIT----GVNARVNLALESARVEHDGSVTGEDL MLBr_02000|M.leprae_Br4923 --MLCAACASRVETKLNKIP----GVRASVNFATRVATIDAVD-VAVDEL Mb0994|M.bovis_AF2122/97 --VHAVHAYPRTASVVIWYSPELGDTAAVLSAITKAQHVPAELVPARAPH Rv0969|M.tuberculosis_H37Rv --VHAVHAYPRTASVVIWYSPELGDTAAVLSAITKAQHVPAELVPARAPH MUL_0423|M.ulcerans_Agy99 --VRAVRAYPRTASVVIWYSPAHCDTAAIVSAIAEAEHAGDASAPAPAAR MMAR_1448|M.marinum_M PNVVQVRQGAPVEIEFDRQESGDCSSRVVFPDLHLSAALPAHQRTTVRFT : . . . . . MSMEG_5014|M.smegmatis_MC2_155 IEVVETAGYTAHLPA-PPQPE----------------------------- Mvan_4449|M.vanbaalenii_PYR-1 VSAVESAGYQAELPE-RPD------------------------------- Mflv_2849|M.gilvum_PYR-GCK IAEVQNAGYSAALPT-PEKPA----------------------------- MAV_5246|M.avium_104 ITEIENAGYAAAVAT-PSPP------------------------------ TH_4361|M.thermoresistible__bu IAAIEATGYTASLPA-PQRDTG---------------------------- MAB_3984c|M.abscessus_ATCC_199 VKAVESVGYTAQVVGGSHQDAH---------------------------- MLBr_02000|M.leprae_Br4923 RQVIEQAGYRATAHAESAVEE----------------------------- Mb0994|M.bovis_AF2122/97 SAGVRGVGVVRKITGGIRRMLS--------------RPPGVDKPLKASRC Rv0969|M.tuberculosis_H37Rv SAGVRGVGVVRKITGGIRRMLS--------------RPPGVDKPLKASRC MUL_0423|M.ulcerans_Agy99 VAGIADGGVVGRVIGGLARALLGMRTDDN----DDDPPPEIARLRAALDR MMAR_1448|M.marinum_M PQQAGSFGFFCSMNMINGTLVVTPDGQAAGSAEPEQPNASIGYAATNSGD * MSMEG_5014|M.smegmatis_MC2_155 ------TGGTEQDPEDRATDALRTRLLVSAVLTVPVI--AMA----MVPA Mvan_4449|M.vanbaalenii_PYR-1 ---------EPAEPTDDPTAALKRRLLICVALSVPVI--AMA----MVPV Mflv_2849|M.gilvum_PYR-GCK ------LTGETGETEDPDLVSLRHRLTGSVLLSVPVI--AMA----MIPV MAV_5246|M.avium_104 -------------RDDPELASLRRRLVTAIALAGPVI--AVA----MIPA TH_4361|M.thermoresistible__bu GAPAGAATGAAGDDHDAEAERWRRRLTISAALSIPVV--VLS----MIPA MAB_3984c|M.abscessus_ATCC_199 AGDHDGHDPHDHMNHDVPDDQLKSRLIGSLILAIPVV--VIS----MAMP MLBr_02000|M.leprae_Br4923 -----------IDPDADYARNLLRRLIVAALLFVPLA--DLSTMFAIVPT Mb0994|M.bovis_AF2122/97 GGRPRGPVRGSASWPGEQNRRERRTWLPRVWLALPLG--LLALG-SSMFF Rv0969|M.tuberculosis_H37Rv GGRPRGPVRGSASWPGEQNRRERRTWLPRVWLALPLG--LLALG-SSMFF MUL_0423|M.ulcerans_Agy99 IGYSPEQDTATQLSPSEQARSGIRFWSRRAWLAWPLG--LLASG-LTMFF MMAR_1448|M.marinum_M EPAAAEIEAAQAQERRAEITDLSRRVAFGAVLSAPVLYAVMAQPLGAGWV * *: :: MSMEG_5014|M.smegmatis_MC2_155 LQFTNWQWLSLTLAAPVVVWGALPFHRAAWLNLRHGTATMDTLISMGTLA Mvan_4449|M.vanbaalenii_PYR-1 LQFTYWQWLSLTLAAPVVVWGAWPFHQAAWTNLRHGTATMDTLISIGTLA Mflv_2849|M.gilvum_PYR-GCK LQFTYWQWASLVLAAPVIVWAAWPFHRAAWANLRHATATMDTLISLGTLS MAV_5246|M.avium_104 LQFQHWHWAALALTAPVVGWCGRPFHAAAWANLKHGVTTMDTLISIGTLA TH_4361|M.thermoresistible__bu LQFTHWQWLALTLTSPVVVWGAWPFHRAAVANLRHGTATMDTLISLGVTA MAB_3984c|M.abscessus_ATCC_199 LHFSGWEILVAALTTPILLWGGYPFHRAALVNARHGASTMDTLVSLGTIA MLBr_02000|M.leprae_Br4923 NRFPGWGYLLTALAAPIVTWAAWPFHRVALRNARYRAASMETLISAGILA Mb0994|M.bovis_AF2122/97 GAYPWAGWLAFAATLPVQFVAGWPILRGAVQQARALTSNMDTLIALGTLT Rv0969|M.tuberculosis_H37Rv GAYPWAGWLAFAATLPVQFVAGWPILRGAVQQARALTSNMDTLIALGTLT MUL_0423|M.ulcerans_Agy99 GAYPWAGWLAFAATIPVQFIAGWPFLVGAVQQARARSANMNTLISLGTLT MMAR_1448|M.marinum_M PAVLLHHWLQLALITPVMFYVGWPIHRTGWLALAHRSADMNSLITLGTFA . *: . *: . : *::*:: * : MSMEG_5014|M.smegmatis_MC2_155 AFGWSLYALFWGTAGVPGMTHPFSLVGSR------TDGAGNIYLEVAAGV Mvan_4449|M.vanbaalenii_PYR-1 ALGWSIYALFWGTAGIPGMTHPFELTIAR------TDGTSNIYLEAAAGV Mflv_2849|M.gilvum_PYR-GCK AFLWSLYALFFGTAGTPGMKHPFELTLAP------SHGAANIYLEVAAGV MAV_5246|M.avium_104 AFLWSLYALVLGAADRPGMRHDFELTVGHGAHVSHVAAPCHVYFEVAAGV TH_4361|M.thermoresistible__bu AYLWSLWALFFTAAGMPGMTMTFTLLPAD-------TGEPHIYLEVAAAV MAB_3984c|M.abscessus_ATCC_199 AYLWSLWVLFANAGHT--------------------HGDVHVYFEVVAAV MLBr_02000|M.leprae_Br4923 ATGWSLSTIFVDKEPRQTHGIWQAILHSD-----------SIYFEVAAGV Mb0994|M.bovis_AF2122/97 AFVYSTYQLFAG---------------------------GPLFFDTSALI Rv0969|M.tuberculosis_H37Rv AFVYSTYQLFAG---------------------------GPLFFDTSALI MUL_0423|M.ulcerans_Agy99 AFIYSTYQLFAG---------------------------GPLFFDTAALI MMAR_1448|M.marinum_M AYGYSLLVTAASTALP--------------------AELQDVYYEAVGVI * :* :: :. . : MSMEG_5014|M.smegmatis_MC2_155 TTFILAGRYFEAKSKRRASAALRALMELGAKDVAILR-NGAEQRIPIDQL Mvan_4449|M.vanbaalenii_PYR-1 TTFILAGRYFEARAKRRAGAALRALLELGAREVTVRR-GGAEQRIPIEQL Mflv_2849|M.gilvum_PYR-GCK TTFILAGRYFEKRSKRQAGAALRALLEMGAKEVSVLR-DGVESKIAVEDL MAV_5246|M.avium_104 TLFVLAGRYFERRSKRTAGAALRALLALGAKDVAVLR-AGAETRIPIERL TH_4361|M.thermoresistible__bu TTFIIAGRYFEARAKRQSGAALRALLDMGANDVAVLR-DGAEKRVPIGEL MAB_3984c|M.abscessus_ATCC_199 TVFLLAGRFAESRAKRSAGSALRALLSLGAKDVAVLR-GGHETRIPVDQL MLBr_02000|M.leprae_Br4923 TVFVLAGRFFEARAKSKAGSALRALAARGAKNVEVLLPNGAELTIPAGEL Mb0994|M.bovis_AF2122/97 IAFVVLGRHLEARATGKASEAISKLLELGAKEATLLV-DGQELLVPVDQV Rv0969|M.tuberculosis_H37Rv IAFVVLGRHLEARATGKASEAISKLLELGAKEATLLV-DGQELLVPVDQV MUL_0423|M.ulcerans_Agy99 IAFVVLGRYFEATAHGKTREAISKLLDMGAKETRLIV-DGEEHLVPVDRV MMAR_1448|M.marinum_M LTLIMLGRLLEARAKAGTGEAIRALLGLQARTARVIR-NGTQAEIPVDEV ::: ** * : : *: * *. . : * : :. : MSMEG_5014|M.smegmatis_MC2_155 GVGDEFVVRPGEKIATDGVVVDGSSAVDASMLTGESVPVEVGPGDQVVGA Mvan_4449|M.vanbaalenii_PYR-1 VIGDEFVVRPGEKIAADGTVVEGASAVDASMLTGESVPEEVQPGDQVVGA Mflv_2849|M.gilvum_PYR-GCK VVGDEFVVRPGEKIATDGVVASGTSAVDASMLTGESVPVEVGPGDTVVGA MAV_5246|M.avium_104 AVGDEFVVRPGERIATDGIVVAGSSAVDAAMLTGESVPVEVGVGDGVTGG TH_4361|M.thermoresistible__bu HVGDVFVVRPGEKIATDGEVVAGNSAVDASMLTGESVPVEVGPGDQVVGA MAB_3984c|M.abscessus_ATCC_199 AVGDEFVVRPGERVATDGEVIEGHSALDTSTMTGESVPMEVTVGGPVLGG MLBr_02000|M.leprae_Br4923 KKQQHFLVRPGETITADGVVIDGTATIDMSAITGEARPVHASPASTVVGG Mb0994|M.bovis_AF2122/97 QVGDLVRVRPGEKIPVDGEVTDGRAAVDESMLTGESVPVEKTAGDRVAGA Rv0969|M.tuberculosis_H37Rv QVGDLVRVRPGEKIPVDGEVTDGRAAVDESMLTGESVPVEKTAGDRVAGA MUL_0423|M.ulcerans_Agy99 QVGDLVRVRPGEKIPVDGEVIDGRAAVDESMLTGESVPVEKGVGDWVAGA MMAR_1448|M.marinum_M VVGDDILVRPGEKIAVDATVVSGQSTVDESMVTGESMPVTKHTGDTVIGA : . ***** :..*. * * :::* : :***: * .. * *. MSMEG_5014|M.smegmatis_MC2_155 TVNVGGRLVVRANRIGSDTQLAQMARLVEDAQSGKAQAQRLADRVSAVFV Mvan_4449|M.vanbaalenii_PYR-1 TVNVDGRLVVRADRVGSDTQLAQMARMVEDAQNGKAQAQRLADRISGVFV Mflv_2849|M.gilvum_PYR-GCK TVNAGGRLVVRAARVGSDTQLAQMAQLVENAQTGKAQVQRLADRISGVFV MAV_5246|M.avium_104 TVNAGGRLVVRATGIGDDTQLARMAQLVERAQSGKADAQRLADRVSGVFV TH_4361|M.thermoresistible__bu TVNVGGHLQVRATRVGADTQLAQMARLVTEAQSGKAEVQRLADRVSAVFV MAB_3984c|M.abscessus_ATCC_199 YVNTHGRIVVRANKVGADTQLARMARLVSDAQTGKAQVQRLADRVSSVFV MLBr_02000|M.leprae_Br4923 TTVLDGRLVIEATAVGGDTQFAAMVRLVEDAQVQKARVQHLADRIAAVFV Mb0994|M.bovis_AF2122/97 TVNLDGLLTVRATAVGADTALAQIVRLVEQAQGDKAPVQRLADRVSAVFV Rv0969|M.tuberculosis_H37Rv TVNLDGLLTVRATAVGADTALAQIVRLVEQAQGDKAPVQRLADRVSAVFV MUL_0423|M.ulcerans_Agy99 TVNTDGLLTVRATAVGADTALAQIVRLVEEAQGGKAPVQRLADRVSAVFV MMAR_1448|M.marinum_M TVNTTGSLRIRAAKVGADTMLAQIIGMVQQAQASRAPIQRLADAISAYFV . * : :.* :* ** :* : :* ** :* *:*** ::. ** MSMEG_5014|M.smegmatis_MC2_155 PIVIALAVATLGFWLG--TGGSVAAAFTAAVAVLIIACPCALGLATPTAL Mvan_4449|M.vanbaalenii_PYR-1 PIVIALSVATLGFWIG--SGFPVAAAFTAAVAVLIIACPCALGLATPTAL Mflv_2849|M.gilvum_PYR-GCK PIVLAIAVITLGAWLG--AGFPVAAAFTAAVAVLVIACPCALGLATPTAL MAV_5246|M.avium_104 PVVLLLAVATLAGWLA--AGGTLATALTAAVAVLIIACPCALGLATPTAL TH_4361|M.thermoresistible__bu PIVIALSALTLAGWLLL-TDAPVSAAFTAAVAVLIIACPCALGLATPTAL MAB_3984c|M.abscessus_ATCC_199 PVVLAISALTFVAWAA--LGNSLASAFTAAVAVLIIACPCALGLATPTAI MLBr_02000|M.leprae_Br4923 PMVFVIAGLAGASWLL--AGASPDRAFSVVLGVLVIACPCTLGLATPTAM Mb0994|M.bovis_AF2122/97 PAVIGVAVATFAGWTLI-AANPVAG-MTAAVAVLIIACPCALGLATPTAI Rv0969|M.tuberculosis_H37Rv PAVIGVAVATFAGWTLI-AANPVAG-MTAAVAVLIIACPCALGLATPTAI MUL_0423|M.ulcerans_Agy99 PVVVRIAAATFAGWTLL-AANPVAG-MTAAVSVLIIACPYALGLATPTAI MMAR_1448|M.marinum_M PVVIAIAIATFAVWFVAGPTPELTQALVSAVAVLIIACPCALGLATPLSI * *. :: : * : .:.**:**** :****** :: MSMEG_5014|M.smegmatis_MC2_155 LVGTGRGAQLGILIKGPEVLESTRRVDTIVLDKTGTITTGSMTLLDVVVA Mvan_4449|M.vanbaalenii_PYR-1 MVGTGRGAQLGILIKGPEVLEDTRRVDTVILDKTGTVTTGSMTLVDVFAA Mflv_2849|M.gilvum_PYR-GCK LVGTGRGAQMGVLIKGPEVLESTRKVDTVVLDKTGTVTTGKMTLVDVVTA MAV_5246|M.avium_104 LVGTGRAAQLGVLIKGPEVLETTRAVDTVVLDKTGTVTTGAMTVLDVVAA TH_4361|M.thermoresistible__bu LVGTGRGAQLGILIKGPQVLESTRRIDTVVLDKTGTVTTGQMSVTSVHVA MAB_3984c|M.abscessus_ATCC_199 LVGTGRGAQLGVLIKGPEVLENVKDIDTVVLDKTGTVTTGVMSVVEVRRS MLBr_02000|M.leprae_Br4923 MVASGRGAQLGIFIKGYRALETINAIDTVVFDKTGTLTLGQLSVSTVTST Mb0994|M.bovis_AF2122/97 MVGTGRGAELGILVKGGEVLEASKKIDTVVFDKTGTLTRARMRVTDVIAG Rv0969|M.tuberculosis_H37Rv MVGTGRGAELGILVKGGEVLEASKKIDTVVFDKTGTLTRARMRVTDVIAG MUL_0423|M.ulcerans_Agy99 IVGTGRGADMGILVKGGEVLEASKKIDTVVFDKTGTLTRAQMELTDVIAG MMAR_1448|M.marinum_M MVGTGKGARAGILIRSAEALETAHKLDTIVLDKTGTVTAGRPALTDVEVT :*.:*:.* *::::. ..** . :**:::*****:* . : * MSMEG_5014|M.smegmatis_MC2_155 DGE---DRDDVLRVAAAVEDASEHPIARAIAAGARERTGELPAVEGFANI Mvan_4449|M.vanbaalenii_PYR-1 EGE---QPDEVLRVAGAVESSSEHPIARAIAAGAQEKFGELPAVTAFTNL Mflv_2849|M.gilvum_PYR-GCK PGT---DRGNLLRLAGALENASEHPIAQAVATAATEELGTLPTPEDFANV MAV_5246|M.avium_104 DGT---DRATLLRYAGALEAASEHPIAHAIARDAKAELGPLPTPTGFRAV TH_4361|M.thermoresistible__bu DGL---SETELLRLAGAVEHASEHPIARAVATHAAQTVPPLPEVSDFENH MAB_3984c|M.abscessus_ATCC_199 IGSGVADADEILRIAASVESASEHPVARAIVAAAASARLTLSPVTNFRNE MLBr_02000|M.leprae_Br4923 GGW---CSGEVLALASAVEAASEHSVATAIVAAYADPR----PVADFVAF Mb0994|M.bovis_AF2122/97 QRR---QPNQVLRLAAAVESGSEHPIGAAIVAAAHERGLAIPAANAFTAV Rv0969|M.tuberculosis_H37Rv QRR---QPDQVLRLAAAVESGSEHPIGAAIVAAAHERGLAIPAANAFTAV MUL_0423|M.ulcerans_Agy99 KRR---QPDVVLRIAAAVESGSEHPIGAAIVAGARERELEVPPATEFTNL MMAR_1448|M.marinum_M GTL---QQNELLALVAAAEANSEHPVATAVLAGSRDRGIDHSAADDFASI :* ..: * ***.:. *: * MSMEG_5014|M.smegmatis_MC2_155 EGLGVQGTVEGRAVVVGRPRLFGDPEKSLPRKLADAMEAAQAQGRTAVVV Mvan_4449|M.vanbaalenii_PYR-1 RGLGVSGQVDGRAVLLGRLRLLADRSHEIPSELEVAVARAESDGRTAVVV Mflv_2849|M.gilvum_PYR-GCK EGKGVQGIVDGHAVVVGRESLLADWSQHLSPELARAKASAEAQGKTAVAV MAV_5246|M.avium_104 GGGGVHGRVDGHAVAIGRPSWLAERGLRPDAALAAAAARAEHDGKTVVAV TH_4361|M.thermoresistible__bu GGNGVSGRVDGHDVRVGRLAWLG---LSAGDRLRNAAAQAEAAGHTPVWV MAB_3984c|M.abscessus_ATCC_199 PGVGVSGVVDGQEVSI----------------------EAIEGQNTTAAV MLBr_02000|M.leprae_Br4923 AGCGVSGVVAEHHVKIGKPSWVTRN-APCDVVLESARREGESRGETVVFV Mb0994|M.bovis_AF2122/97 AGHGVRAQVNGGPVVVGRRKLVDEQHLVLPDHLAAAAVEQEERGRTAVFV Rv0969|M.tuberculosis_H37Rv AGHGVRAQVNGGPVVVGRRKLVDEQHLVLPDHLAAAAVEQEERGRTAVFV MUL_0423|M.ulcerans_Agy99 AGHGVRGEVGGKSVLVGRRKLVDEQHLRLPEQLAAAAADLEERGRTAVYV MMAR_1448|M.marinum_M TGKGVRATVAGRTVLVGTATLLAEN-NVTTSELERIGADLAAKGKTPILA * ** . * * : .* . MSMEG_5014|M.smegmatis_MC2_155 GWDGTARGVLVVADAVKATSAEAIGQLRKLGLQPIMLTGDNGAAARAIAD Mvan_4449|M.vanbaalenii_PYR-1 GWDGQARGVLMVADAVKPTSAEAISLLKRLGLTPIMVTGDNEAVARAVAA Mflv_2849|M.gilvum_PYR-GCK GWDGEARGVLVVADTVKPTSAQAISQMREIGLTPVLLTGDNEAVARQIAA MAV_5246|M.avium_104 GWDGRARGILALADTVKPSSAAAVRQFTRLGLTPILLTGDNHTVARRTAG TH_4361|M.thermoresistible__bu AVDGRIAGVIVVSDTVKDHAAEAIAELRALGATPVLLTGDNDRAARTVAA MAB_3984c|M.abscessus_ATCC_199 SWGGLRRGEIEVADTVKPSSRRAIDELKAMGITPVLLTGDNAEVAARVAS MLBr_02000|M.leprae_Br4923 SVDGVACGAVAIADTVKDSAADAISALCSRGLHTILLTGDNQAAARAVAA Mb0994|M.bovis_AF2122/97 GQDGQVVGVLAVADTVKDDAADVVGRLHAMGLQVAMITGDNARTAAAIAK Rv0969|M.tuberculosis_H37Rv GQDGQVVGVLAVADTVKDDAADVVGRLHAMGLQVAMITGDNARTAAAIAK MUL_0423|M.ulcerans_Agy99 GQDGQVVGVLAVADTVKDDAADVVSQLHAMGLQVALITGDNARTAAAIAA MMAR_1448|M.marinum_M AVDGRPAGVLAVADTVKDDSMAAIAALGKLGLQVVMITGDNARTAKAIAR . .* * : ::*:** : .: : * ::**** .* * MSMEG_5014|M.smegmatis_MC2_155 QVGID--DVYAEVLPQDKADVIKRLQAEGRVVAMVGDGVNDAAALAQADL Mvan_4449|M.vanbaalenii_PYR-1 EVGID--EVIAGVLPQDKVDTVKRLQRDGKVVAMVGDGVNDAAALAQADL Mflv_2849|M.gilvum_PYR-GCK EVGID--TVIAEVMPKDKVDVIVRLQAEGKTVAMVGDGVNDAPALAQADL MAV_5246|M.avium_104 ELGIG--EVISGALPADKVEAVKRLQSAGRVVAMVGDGVNDAAALAAADL TH_4361|M.thermoresistible__bu QVGID--DVIAGVLPAEKVDHIKQLQDRGRVVAMIGDGVNDAAALAQADL MAB_3984c|M.abscessus_ATCC_199 EVGIAAGDVIAGVKPTEKADVVKRLQAEGKRVAMVGDGVNDSAALATADI MLBr_02000|M.leprae_Br4923 QVGID--TVIADMLPEAKVDVIQRLRDQGHTVAMVGDGINDGPALACADL Mb0994|M.bovis_AF2122/97 QVGIE--KVLAEVLPQDKVAEVRRLQDQGRVVAMVGDGVNDAPALVQADL Rv0969|M.tuberculosis_H37Rv QVGIE--KVLAEVLPQDKVAEVRRLQDQGRVVAMVGDGVNDAPALVQADL MUL_0423|M.ulcerans_Agy99 QVGID--RVLAEVLPADKVNEVRRLQDEGRIVAMVGDGVNDAPALVQADL MMAR_1448|M.marinum_M QVGVS--RVLAEVLPEHKAGEIRRLQAEGRTVGMVGDGINDAPALAQADV ::*: * : * *. : :*: *: *.*:***:**..**. **: MSMEG_5014|M.smegmatis_MC2_155 GLSMGTGTDVAIEAGDLTLVRGDLRTAADAIRLSRRTLATIKGNLFWAFA Mvan_4449|M.vanbaalenii_PYR-1 GLAMGSGTDVAIEASDLTLVSNDLRAVPDAIRLSRKTLSTIKGNLFWAFA Mflv_2849|M.gilvum_PYR-GCK GLAMGTGTDVAIEASDITLVRGDLRSAVDAIRLSRRTLSTIKTNLFWAFV MAV_5246|M.avium_104 GLAMGTGTDVAIEAADVTVVRGDLRAAVDAIRLSRRTLATIKTNLVWAFG TH_4361|M.thermoresistible__bu GLAIGTGTDVAIEASDLTLVTGDLRAAPDAIRLGRATLRTIKGNLFWAFA MAB_3984c|M.abscessus_ATCC_199 GMAMGTGTDAAIEASDLTLVRGDLTTVPTALRLSRKTLGTIKANLFWAFA MLBr_02000|M.leprae_Br4923 GLAMGRGTDVAIGAADLILVRDSLGVVPVALDLARATMRTIRINMIWAFG Mb0994|M.bovis_AF2122/97 GIAIGTGTDVAIEASDITLMSGRLDGVVRAIELSRQTLRTIYQNLGWAFG Rv0969|M.tuberculosis_H37Rv GIAIGTGTDVAIEASDITLMSGRLDGVVRAIELSRQTLRTIYQNLGWAFG MUL_0423|M.ulcerans_Agy99 GIAIGTGTDVAIEASDITLMSGRLDGVVSAIELSRRTLRTIYQNLGWAFG MMAR_1448|M.marinum_M GLAIGTGTDVAIEAADITLISGSLAGVVTAIQLSRATMRNIRENLFFALI *:::* ***.** *.*: :: . * . *: *.* *: .* *: :*: MSMEG_5014|M.smegmatis_MC2_155 YNVAALPLAA------AGL-LNPMLAGAAMAFSSVFVVSNSLRLKRFR-- Mvan_4449|M.vanbaalenii_PYR-1 YNVAALPLAA------AGL-LNPMIAGAAMAFSSVFVVSNSLRLRAFTPS Mflv_2849|M.gilvum_PYR-GCK YNVAAIPVAA------LGM-LNPMLAGAAMAFSSVFVVGNSLRLRGFTST MAV_5246|M.avium_104 YNLAAIPLAA------LGM-LNPMLAGAAMALSSVLVVGNSLRLRSFASI TH_4361|M.thermoresistible__bu YNVAALPLAA------AGL-LNPLIAGAAMAFSSVFVVSNSLRLRRFTPS MAB_3984c|M.abscessus_ATCC_199 YNTAAIPLAA------LGL-LNPMIAGAAMAMSSVFVVLNSLRLRTFR-- MLBr_02000|M.leprae_Br4923 YNVAAIPIAS------SGL-LNPLIAGAAMAFSSFFVVSNSLRLSNFGLS Mb0994|M.bovis_AF2122/97 YNTAAIPLAA------LGA-LNPVVAGAAMGFSSVSVVTNSLRLRRFGRD Rv0969|M.tuberculosis_H37Rv YNTAAIPLAA------LGA-LNPVVAGAAMGFSSVSVVTNSLRLRRFGRD MUL_0423|M.ulcerans_Agy99 YNTAAIPLAA------LGV-LNPVVAGAAMGLSSVSVVTNSLRLRRFGRD MMAR_1448|M.marinum_M YNAIGIPLAAGVLYPTLGLRLSPMIAAAAMALSSLSVVGNANRLRRYRVE ** .:*:*: * *.*::*.***.:**. ** *: ** : MSMEG_5014|M.smegmatis_MC2_155 -------------------------- Mvan_4449|M.vanbaalenii_PYR-1 R------------------------- Mflv_2849|M.gilvum_PYR-GCK STSSAPTH------------------ MAV_5246|M.avium_104 IPGA---------------------- TH_4361|M.thermoresistible__bu R------------------------- MAB_3984c|M.abscessus_ATCC_199 -------------------------- MLBr_02000|M.leprae_Br4923 QTSD---------------------- Mb0994|M.bovis_AF2122/97 GRTA---------------------- Rv0969|M.tuberculosis_H37Rv GRTA---------------------- MUL_0423|M.ulcerans_Agy99 V------------------------- MMAR_1448|M.marinum_M PLPPAEAPTTEPRVETVTAQSESGDR