For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. marinum M MMAR_1391 (-)

annotation: PE-PGRS family protein, PE_PGRS9
coordinates: 1689881 - 1692475
length: 864
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*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_1391--100% (864)PE-PGRS family protein, PE_PGRS9
M. marinum MMMAR_4398-0.064.62% (927) PE-PGRS family protein, PE_PGRS9_3
M. marinum MMMAR_4399-0.065.84% (925) PE-PGRS family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0767PE_PGRS90.062.34% (879) PE-PGRS family protein
M. gilvum PYR-GCKMflv_5091-1e-15346.57% (773) triple helix repeat-containing collagen
M. tuberculosis H37RvRv0746PE_PGRS90.063.94% (832) PE-PGRS family protein
M. leprae Br4923MLBr_01183-7e-1140.23% (87) hypothetical protein MLBr_01183
M. abscessus ATCC 19977MAB_4284c-4e-5133.13% (495) hypothetical protein MAB_4284c
M. avium 104MAV_4827-5e-2443.64% (165) hypothetical protein MAV_4827
M. smegmatis MC2 155MSMEG_0868-1e-11938.66% (895) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3810-1e-3942.24% (303) PUTATIVE -
M. ulcerans Agy99MUL_2485-0.095.16% (744) PE-PGRS family protein
M. vanbaalenii PYR-1Mvan_1264-1e-14846.23% (796) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_1391|M.marinum_M               --------------------------------------------------
MUL_2485|M.ulcerans_Agy99           --------------------------------------------------
Mb0767|M.bovis_AF2122/97            --------------------------------------------------
Rv0746|M.tuberculosis_H37Rv         --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_1391|M.marinum_M               ------------------MTLVDVVPGMVQAAANDLAGLNTTLNAANAAA
MUL_2485|M.ulcerans_Agy99           ------------------MTLVDVVPGMVQAAANDLAGLNTTLNAANAAA
Mb0767|M.bovis_AF2122/97            ------------------MSFVLAMPEVLGSAATDLAALGSVLGAADAAA
Rv0746|M.tuberculosis_H37Rv         ------------------MSFVLAMPEVLGSAATDLAALGSVLGAADAAA
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------MSIIDFILNLFRDPVEAASYVADPEAALANAG
MAV_4827|M.avium_104                ------------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEED
                                                                                      

MMAR_1391|M.marinum_M               ATQITTVVAAAQDEVSAAIAAQFSGHGLAYQQLSTQVGVFSDQFVAALSA
MUL_2485|M.ulcerans_Agy99           ATQITTVVAAAQDEVSAAIAAQFSGHGLAYQQLSTQVGVFSDQFVAALSA
Mb0767|M.bovis_AF2122/97            AATTTGIVAAVQDEVSAAIAALFSAHGRAYQVASAQAAAVHAQFVEALSA
Rv0746|M.tuberculosis_H37Rv         AATTTGIVAAAQDEVSAAIAALFSAHGRAYQVASAQAAAVHAQFVEALSA
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      LSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAA
MAV_4827|M.avium_104                AIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEA
                                                                                      

MMAR_1391|M.marinum_M               SAS-----------------------------------------------
MUL_2485|M.ulcerans_Agy99           SAS-----------------------------------------------
Mb0767|M.bovis_AF2122/97            GAG-----------------------------------------------
Rv0746|M.tuberculosis_H37Rv         GAG-----------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      QPD-----------------------------------------------
MAV_4827|M.avium_104                AALR----------------------------------------------
                                                                                      

MMAR_1391|M.marinum_M               ---------------------GYSAAEAANTGPLQ--------QLLTLIN
MUL_2485|M.ulcerans_Agy99           ---------------------GYSAAEAANTGPLQ--------QLLTLIN
Mb0767|M.bovis_AF2122/97            ---------------------AYASAEAAGAAVLANPAQSVQQDLLAAVN
Rv0746|M.tuberculosis_H37Rv         ---------------------AYASAEAAGAAVLANPAQSVQQDLLAAVN
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------------GPSILSPSLLSPRDNDFLSHNDTDFA
MAV_4827|M.avium_104                --------------------------------------DALAARRIDNVM
                                                                                      

MMAR_1391|M.marinum_M               APLLAATGRPLIGNGANGAPG-----TGANGGDGGWLLGDGGIGGSGTPG
MUL_2485|M.ulcerans_Agy99           APLLAATGRPLIGNGANGAPG-----TGANGGDGGWLLGDGGIGGSGTPG
Mb0767|M.bovis_AF2122/97            AQSVALTGRPLIGNGANGAPG-----TGANGAPGGWLLGNGGAGGSAAAG
Rv0746|M.tuberculosis_H37Rv         AQSVALTGRPLIGNGANGAPG-----TGANGAPGGWLLGNGGAGGSAAAG
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
TH_3810|M.thermoresistible__bu      ------------------------------------------------VD
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVA
MAV_4827|M.avium_104                LVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVY
                                                                                      

MMAR_1391|M.marinum_M               TVANPTGGIGGAGGAAGLLGSGGAGGA---GGSSAFGDGGAGGVGGAGGW
MUL_2485|M.ulcerans_Agy99           TVANPTGGVGGVGGAAGLLGSGGAGGA---GGSSAFGDGGAGGVG---GW
Mb0767|M.bovis_AF2122/97            -----SGLPGGAGGAAGLFGTGGAGGA---GGSSTVGDGGAGGAGGSGGW
Rv0746|M.tuberculosis_H37Rv         -----SGLPGGAGGAAGLFGTGGAGGA---GGSSTVGDGEAGGAGGSGGW
Mflv_5091|M.gilvum_PYR-GCK          G----NGGNGGNAGAFALFGNGGNGGN---GGVGVVGATGAVG--APGVA
Mvan_1264|M.vanbaalenii_PYR-1       G----DGGNGGDAGLFSLFGRGGNGGN---GGVGIAGATGAVG--APGVA
MSMEG_0868|M.smegmatis_MC2_155      L----DGGNGGSGG--LLMGIGGAGGA---GGVGADGTSAHVDGGTGGTG
TH_3810|M.thermoresistible__bu      G----DGGSGGRTGLFSKLSRGGDGGD---GGLG-------------GNG
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      VGGSNSGPIASGQGSTAVNGDVRDSNI---INADHGSNVGVDQSQTRVGG
MAV_4827|M.avium_104                KQQIRAESYGDAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQ
                                                                                      

MMAR_1391|M.marinum_M               LSGNAGAGGAGGPGLFGFNGGAGGAGGAGGLLGAGGLGGAGG--------
MUL_2485|M.ulcerans_Agy99           LSGNAGAGGAGGPGLFGFNG---GAGGAGGLLGAGGLGGAGG--------
Mb0767|M.bovis_AF2122/97            LLGTGGVGGVGGLGAG--AGGAGGVGGAGGLLGAGGHGGAGG--------
Rv0746|M.tuberculosis_H37Rv         LLGTGGVGGVGGLGAG--AGGAGGVGGAGGLLGAGGHGGAGG--------
Mflv_5091|M.gilvum_PYR-GCK          GATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------
Mvan_1264|M.vanbaalenii_PYR-1       GATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------
MSMEG_0868|M.smegmatis_MC2_155      GTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVL
TH_3810|M.thermoresistible__bu      GHGGGTGIIS--------------------LLSLAGNGGNGG--------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      DYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTN--------
MAV_4827|M.avium_104                TTTFLDVSVAEEPETALARGAALAAANAPLFASSTAALAYAQ--------
                                                                                      

MMAR_1391|M.marinum_M               -------YGPGGVGGTGGAGGAGGLLAGLVGAGGGHGGTGGFGAGGTGGD
MUL_2485|M.ulcerans_Agy99           -------YGPGGVGGTGGAGGAGGLLAGLVGAGGGHGGTGGFGAGGTGGD
Mb0767|M.bovis_AF2122/97            -------LG-AVTGGVGGAGGAGGLLA-----------------------
Rv0746|M.tuberculosis_H37Rv         -------LG-AVTGGVGGTGGAGGLLA-----------------------
Mflv_5091|M.gilvum_PYR-GCK          ------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG---------
Mvan_1264|M.vanbaalenii_PYR-1       ------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG---------
MSMEG_0868|M.smegmatis_MC2_155      IAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGAN
TH_3810|M.thermoresistible__bu      -------NGYRTTDNNALDGGHGG--------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -------IGSGNTTNTEIGSHNQANIG-----------------------
MAV_4827|M.avium_104                ------DPGTGAVDQYSLPDYLYVPVDP----------------------
                                                                                      

MMAR_1391|M.marinum_M               GGAGGNAGLFGGPGGAGGTGGVGTGGDGGNGGAG----------------
MUL_2485|M.ulcerans_Agy99           GGAGGNAGLFGGPGGAGGTGGVGTGGDGGNGGAG----------------
Mb0767|M.bovis_AF2122/97            -------GLLAGPGGAGGTGGRGFLNDGGVGGAG----------------
Rv0746|M.tuberculosis_H37Rv         -------GLLAGPGGAGGTGGRGFLNNGGVGGAG----------------
Mflv_5091|M.gilvum_PYR-GCK          -------AVGAAGAAG------TVGTAGATGGTG---------------T
Mvan_1264|M.vanbaalenii_PYR-1       -------AIGTAGVAG------AAGTAGATGGTG---------------V
MSMEG_0868|M.smegmatis_MC2_155      GGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTAT
TH_3810|M.thermoresistible__bu      -------------------------------------------------N
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------------------TSTSAGGSAAVG----------------
MAV_4827|M.avium_104                ---------------------EPGDDELAYSAVG----------------
                                                                                      

MMAR_1391|M.marinum_M               GNAGALFGTGGAGGAGGSG-----------VAGAGGVGGAGGNAGLLFSA
MUL_2485|M.ulcerans_Agy99           GNAGALFGTGGAGGAGGSG-----------VAGAGGVGGAGGNAGLLFSA
Mb0767|M.bovis_AF2122/97            GNAGLLFGAGGTGGSGGAG-----------LGGDGGAGGAGGNAGVLFGN
Rv0746|M.tuberculosis_H37Rv         GNAGLLFGAGGTGGSGGAG-----------LGGDGGAGGAGGNTGVLFGN
Mflv_5091|M.gilvum_PYR-GCK          GANGGAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGA
Mvan_1264|M.vanbaalenii_PYR-1       GGNGGAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGV
MSMEG_0868|M.smegmatis_MC2_155      GGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGA
TH_3810|M.thermoresistible__bu      GGNVGFFSLFNLGG--------------------AGGWGGSGVDG-----
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -GNAGLAGNAGLAGNAGLAG----------NAGLAGNAGLAGNAGLAGNA
MAV_4827|M.avium_104                -EEDAESPTVVIEKLFLPE-------------DSEPRRRPVLLVGSGLAV
                                                                                      

MMAR_1391|M.marinum_M               GGVGGAGGYGSSDGGAGGAGGNGGLLYSNGGVGGTGG-------------
MUL_2485|M.ulcerans_Agy99           GGVGGAGGYGSSDGGAGGAGGNGGLLYSNGGVGGTGG-------------
Mb0767|M.bovis_AF2122/97            AGSGGTGGFGDTDGGAGGAGGDAGWLGS-GGVGGAGG-------------
Rv0746|M.tuberculosis_H37Rv         AGSGGTGGFGDTDGGAGGAGGDAGWLGS-GGVGGAGG-------------
Mflv_5091|M.gilvum_PYR-GCK          GGVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG----
Mvan_1264|M.vanbaalenii_PYR-1       GGIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG----
MSMEG_0868|M.smegmatis_MC2_155      GGMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTG
TH_3810|M.thermoresistible__bu      ----------------VDVVGGNP--------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG-------------
MAV_4827|M.avium_104                VGISAVLALEIALAIGIRTTGTVALQPTPNQHLIVPT-------------
                                                                                      

MMAR_1391|M.marinum_M               -----------YGAAAAGGAGGAGGRAGLAIG------------------
MUL_2485|M.ulcerans_Agy99           -----------YGAAAAGGVGGAGGRAGLAIG------------------
Mb0767|M.bovis_AF2122/97            -----------FGETGDGGVGGAGGKAGLLIG------------------
Rv0746|M.tuberculosis_H37Rv         -----------FGETGDGGVGGAGGKAGLLIG------------------
Mflv_5091|M.gilvum_PYR-GCK          ---------LQGGKGGDGGAGGKGGDADSMGS------------------
Mvan_1264|M.vanbaalenii_PYR-1       ---------LQGGQGGDGGTGGTGGDATSMGE------------------
MSMEG_0868|M.smegmatis_MC2_155      GKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGA
TH_3810|M.thermoresistible__bu      ----------------DGGTPG----------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----------LAGNAGLAGNAGLAGNAGLAGN------------------
MAV_4827|M.avium_104                -----------EQAPAPPPVQASAPQPKISVP------------------
                                                                                      

MMAR_1391|M.marinum_M               ---GGGAGGAGGEGATTGGDGGAGGTG-----------------------
MUL_2485|M.ulcerans_Agy99           ---GGGAGGAGGEGATTGGDGGAGGTG-----------------------
Mb0767|M.bovis_AF2122/97            ---NGGAGGAG---------------------------------------
Rv0746|M.tuberculosis_H37Rv         ---NGGAGGAGGQGAVTGGTGGAGGDG-----------------------
Mflv_5091|M.gilvum_PYR-GCK          AGATGGKGGNGGNGGRGGLFG---------------KGGNAGNGAD----
Mvan_1264|M.vanbaalenii_PYR-1       AGATGGKGGNGGNGGRGSLFG---------------RGGNAGNGGN----
MSMEG_0868|M.smegmatis_MC2_155      ASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQ
TH_3810|M.thermoresistible__bu      --AHGESHTPGVYTDRQ---------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ----AGLAGNAGLAGNAGLAG-----------------------------
MAV_4827|M.avium_104                ----EPVAAPKPLSPPVAAPLP----------------------------
                                                                                      

MMAR_1391|M.marinum_M               ----------------VLIGNGGNAGVGGTGPAAGATGVGGTSG------
MUL_2485|M.ulcerans_Agy99           ----------------VLIGNGGNAGVGGTGPAAGATGVGGTSG------
Mb0767|M.bovis_AF2122/97            ----------------VLIGNGGNAGIGGTGPTAGDTGAGGISG------
Rv0746|M.tuberculosis_H37Rv         ----------------VLIGNGGNAGIGGTGPTAGDTGAGGISG------
Mflv_5091|M.gilvum_PYR-GCK          ------------------GGTGGAGGAGGTGG-TGGAGGTGG--------
Mvan_1264|M.vanbaalenii_PYR-1       ------------------GGTGGNGGNGGTGG-TGGNGGTGG--------
MSMEG_0868|M.smegmatis_MC2_155      AYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKAN
TH_3810|M.thermoresistible__bu      ----------------------GEDGEDGTGTGIGGRGGNGG--------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      -----------------NAGLAGNAGLAGNAAVAGNAAVAGNAA------
MAV_4827|M.avium_104                -----------------------AAPPPAAPPLPEAPPIPAAPP------
                                                                                      

MMAR_1391|M.marinum_M               --------LLLGLDGFNAPASTSPLHTFQQQALGAVNAPVQTLTGRPLIG
MUL_2485|M.ulcerans_Agy99           --------LLLGLDGFNAPASTSPLHTFQQQALGAVNAPVQTLTGRPLIG
Mb0767|M.bovis_AF2122/97            --------LLLGADGFNAPASASPLHTLKQQALAAINAPTQTLTGRPLIG
Rv0746|M.tuberculosis_H37Rv         --------LLLGADGFNTPASASPLHTLKQQALAAINAPTQTLTGRPLIG
Mflv_5091|M.gilvum_PYR-GCK          ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1       ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155      GQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGH
TH_3810|M.thermoresistible__bu      --------SSSGTHPMAEDG--------EHVKALDGRPGLD---GGNGSH
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------VAGNAAVGGVLNTGVSGAIGGSSHVGG--AINESLGGSGSV
MAV_4827|M.avium_104                --------VVPVPVVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQPV
                                                                                      

MMAR_1391|M.marinum_M               NGTPGAAGSGAAGTAGGWVF------GDGGAGGSGAMS----------TG
MUL_2485|M.ulcerans_Agy99           NGTPGAAGSGAAGTAGGWVF------GDGGADGSGAMS----------TG
Mb0767|M.bovis_AF2122/97            NGTPGAVGSGATGAPGGWLL------GDGGAGGSGAAG----------SG
Rv0746|M.tuberculosis_H37Rv         NGTPGAVGSGATGAPGGWLL------GDGGAGGSGAAG----------SG
Mflv_5091|M.gilvum_PYR-GCK          GGTGGKGGTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTG
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGKGGTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTG
MSMEG_0868|M.smegmatis_MC2_155      GGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAG
TH_3810|M.thermoresistible__bu      GGNGGHGGRGGFLGIGGSG-------GWGGHGGNGGD-----------TD
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      GGSTAVGGGAHTGVGGGVSTG----VGVGSHVGGG------------ISE
MAV_4827|M.avium_104                QPPVRVPQPPSPPQVGGTVPQ-----SPPQHQTPPGEG---------TPP
                                                                                      

MMAR_1391|M.marinum_M               ADGGAGGAAG------------MWGTGGSGGAG-----------------
MUL_2485|M.ulcerans_Agy99           ADGGAGGAAG------------MWGTGGSGGAG-----------------
Mb0767|M.bovis_AF2122/97            APGGAGGAAG------------LWGTGGAG--------------------
Rv0746|M.tuberculosis_H37Rv         APGGAGGAAG------------LWGTGGAGGAGG----------------
Mflv_5091|M.gilvum_PYR-GCK          GTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG---
Mvan_1264|M.vanbaalenii_PYR-1       GTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG---
MSMEG_0868|M.smegmatis_MC2_155      GNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEAL
TH_3810|M.thermoresistible__bu      ADGGNGGDG---------------GNGGSAG-------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SLGGSGSVG---------------GSTAVGG-------------------
MAV_4827|M.avium_104                KPDGPGNYGG--------------GHVPTPG-------------------
                                                                                      

MMAR_1391|M.marinum_M               -------------AAGIGGGLTGGAGGAGGAGGWLT--GTGGAGGSGGYS
MUL_2485|M.ulcerans_Agy99           -------------PAGIGGGLTGGAGGAGGAG---------------GYS
Mb0767|M.bovis_AF2122/97            ---------------GAGGWLLG-DGGAGGIGG----------------A
Rv0746|M.tuberculosis_H37Rv         ---SSAGGGGAGGAGGAGGWLLG-DGGAGGIGG----------------A
Mflv_5091|M.gilvum_PYR-GCK          --------------TGGTGGQGG-LGGGGGTG------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------TGGTGGQGG-LGGVGGTG------------------
MSMEG_0868|M.smegmatis_MC2_155      IRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQAS
TH_3810|M.thermoresistible__bu      --------------RGGTGGLRGVFGINGGNG------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ---------------GAHTGVGGGVSTGVGVG------------------
MAV_4827|M.avium_104                --------------AGGSGGSGGGHVPTPGAG------------------
                                                                                      

MMAR_1391|M.marinum_M               STADGGVGGAGGAGGLWGGGGIGGTGGFG--------ALNG--AAGGVGG
MUL_2485|M.ulcerans_Agy99           STADGGVGGAGGAGGLWGGGGIGGTGGFG--------ALNG--AAGGVGG
Mb0767|M.bovis_AF2122/97            STVLGGTGGGGGVGGLWGAGGAGGAGGTG--------LVGGDGGAGGAGG
Rv0746|M.tuberculosis_H37Rv         STVLGGTGGGGGVGGLWGAGGAGGAGGTG--------LVGGDGGAGGAGG
Mflv_5091|M.gilvum_PYR-GCK          -----GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGG
Mvan_1264|M.vanbaalenii_PYR-1       -----GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGG
MSMEG_0868|M.smegmatis_MC2_155      GTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGG
TH_3810|M.thermoresistible__bu      ------RAGLGGRGXXXXGGGVGAAVRSG---------------NGVFSG
MLBr_01183|M.leprae_Br4923          ------MPLFLNAEPQALTAAANTLEGLS---------------AATVAS
MAB_4284c|M.abscessus_ATCC_199      -----SHVGGGISESLGGSGSVGGSTAVG---------------GGAHTG
MAV_4827|M.avium_104                -------GSGGSGGGHVPTPGTGGPGGTG----------------GSGGG
                                                        . .     .                .   .

MMAR_1391|M.marinum_M               AGGLLGGLVGAGGGDGGAGGYGLTGAGGAGG------------------A
MUL_2485|M.ulcerans_Agy99           AGGLLGGLVGAGGGDGGAGGYGLTGAGGAGG------------------A
Mb0767|M.bovis_AF2122/97            TGGLLAGLIGAGGGHGGTGGLNTNGDGGVGG------------------A
Rv0746|M.tuberculosis_H37Rv         TGGLLAGLIGAGGGHGGTGGLSTNGDGGVGG------------------A
Mflv_5091|M.gilvum_PYR-GCK          LGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----G
Mvan_1264|M.vanbaalenii_PYR-1       LGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----G
MSMEG_0868|M.smegmatis_MC2_155      LGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQ
TH_3810|M.thermoresistible__bu      GGGTPSAGFGVPTTIQFPAGSCTSRAVSREG-------------------
MLBr_01183|M.leprae_Br4923          NAAAAQLTTEIAPPAADDVSILLAHFFSGHG-------------------
MAB_4284c|M.abscessus_ATCC_199      VGGGVNTGVGVGSHVGGGISESLGGSGSVGG------------------S
MAV_4827|M.avium_104                HVPTPGAGTPGGSGGGHLPFPGAGSTPGGSG-------------------
                                                               .  *                   

MMAR_1391|M.marinum_M               GGNSGLLSGPGGSGGTGGAG-AVADGGVGGAG--------GSAGLLFGSG
MUL_2485|M.ulcerans_Agy99           GGNSGLLSGPGGSGGTGGAG-AVADGAVGGAG--------GSAGLLFGSG
Mb0767|M.bovis_AF2122/97            GGNAGMLAGPGGAGGAGGDGENLDTGGDGGAG--------GSAGLLFGSG
Rv0746|M.tuberculosis_H37Rv         GGNAGMLAGPGGAGGAGGDGENLDTGGDGGAG--------GSAGLLFGSG
Mflv_5091|M.gilvum_PYR-GCK          SGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAA
Mvan_1264|M.vanbaalenii_PYR-1       SGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGAS
MSMEG_0868|M.smegmatis_MC2_155      SGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNT
TH_3810|M.thermoresistible__bu      -----IMPSSRAASARAG---------------------------AACAS
MLBr_01183|M.leprae_Br4923          ----RQYQAHASQGATNHQD--------------------LIQSLLTSSS
MAB_4284c|M.abscessus_ATCC_199      TAVGGGAHTSAINDALGGSGSVGGSTAVG-----------GGAHTSAINE
MAV_4827|M.avium_104                ---GGHLPTPGAGTPGGGLGGFG-----------------GGHAPAPGGG
                                                                                      

MMAR_1391|M.marinum_M               GIGGDGGFGSNTGGAGGAGGNAGLLFSSAGAGGFGGFGVANGGGSGGAGG
MUL_2485|M.ulcerans_Agy99           RIGGDGGFGSNTG-------------------------------------
Mb0767|M.bovis_AF2122/97            GAGGAGGFG-FLGGDGGAGGNAGLLLSSGGAGGFGGFG--TAGGVGGAGG
Rv0746|M.tuberculosis_H37Rv         GAGGAGGFG-FLGGDGGAGGNAGLLLSSGGAGGFGGFG--TAGGVGGAGG
Mflv_5091|M.gilvum_PYR-GCK          GKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGS
Mvan_1264|M.vanbaalenii_PYR-1       GAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGS
MSMEG_0868|M.smegmatis_MC2_155      ATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGG
TH_3810|M.thermoresistible__bu      STSRSRRSFCCSRA------------------------------------
MLBr_01183|M.leprae_Br4923          AYAGTETANHDSL-------------------------------------
MAB_4284c|M.abscessus_ATCC_199      SMNSSINASHSSSMNESFG-------------------------------
MAV_4827|M.avium_104                LGGGGGHAPAPGGGLGGFG-------------------------------
                                                                                      

MMAR_1391|M.marinum_M               NAGLLGCGGAGGAGGLGIAGTGGSGGAGGTGGVLLGTGGAGGSGAESLGV
MUL_2485|M.ulcerans_Agy99           --------------------------------------------------
Mb0767|M.bovis_AF2122/97            NAGWLGFGGAGGIGGIGGNANGGAGGNGGTGGQLWGSGGAGGEGGAALSV
Rv0746|M.tuberculosis_H37Rv         NAGWLGFGGAG---------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          QGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG
Mvan_1264|M.vanbaalenii_PYR-1       QGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG
MSMEG_0868|M.smegmatis_MC2_155      KGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGG
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4827|M.avium_104                --------------------------------------------------
                                                                                      

MMAR_1391|M.marinum_M               GDSGGAGGMGGNAVLIGTGGNGGNGGVGAG--------TGTRGAGGSGGL
MUL_2485|M.ulcerans_Agy99           ------------------------------------------GAGGSGGL
Mb0767|M.bovis_AF2122/97            GDTGGAGGVGGSAGLIGTGGNGGNGGTGAN--------AGSPGTGGAGGL
Rv0746|M.tuberculosis_H37Rv         -------GVGGSAGLIGTGGNGGNGGTGAN--------AGSPGTGGAGGL
Mflv_5091|M.gilvum_PYR-GCK          -----------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGS
Mvan_1264|M.vanbaalenii_PYR-1       -----------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGS
MSMEG_0868|M.smegmatis_MC2_155      NTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGT
TH_3810|M.thermoresistible__bu      --------------------------------------------------
MLBr_01183|M.leprae_Br4923          --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      ------------------SSMGSHGAAGTG--------FEAQGHAQGHAS
MAV_4827|M.avium_104                ---------------------------------------GGHSGGGLGGL
                                                                                      

MMAR_1391|M.marinum_M               LLGQDGSDGLP-----------------------
MUL_2485|M.ulcerans_Agy99           LLGQDGSDGLP-----------------------
Mb0767|M.bovis_AF2122/97            LLGQNGLNGLP-----------------------
Rv0746|M.tuberculosis_H37Rv         LLGQNGLNGLP-----------------------
Mflv_5091|M.gilvum_PYR-GCK          GAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1       GTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155      TAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP
TH_3810|M.thermoresistible__bu      ----------------------------------
MLBr_01183|M.leprae_Br4923          ----------------------------------
MAB_4284c|M.abscessus_ATCC_199      ETAHTTLPGAEHH---------------------
MAV_4827|M.avium_104                GGGHK-----------------------------