For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TLVDVVPGMVQAAANDLAGLNTTLNAANAAAATQITTVVAAAQDEVSAAIAAQFSGHGLAYQQLSTQVGV FSDQFVAALSASASGYSAAEAANTGPLQQLLTLINAPLLAATGRPLIGNGANGAPGTGANGGDGGWLLGD GGIGGSGTPGTVANPTGGIGGAGGAAGLLGSGGAGGAGGSSAFGDGGAGGVGGAGGWLSGNAGAGGAGGP GLFGFNGGAGGAGGAGGLLGAGGLGGAGGYGPGGVGGTGGAGGAGGLLAGLVGAGGGHGGTGGFGAGGTG GDGGAGGNAGLFGGPGGAGGTGGVGTGGDGGNGGAGGNAGALFGTGGAGGAGGSGVAGAGGVGGAGGNAG LLFSAGGVGGAGGYGSSDGGAGGAGGNGGLLYSNGGVGGTGGYGAAAAGGAGGAGGRAGLAIGGGGAGGA GGEGATTGGDGGAGGTGVLIGNGGNAGVGGTGPAAGATGVGGTSGLLLGLDGFNAPASTSPLHTFQQQAL GAVNAPVQTLTGRPLIGNGTPGAAGSGAAGTAGGWVFGDGGAGGSGAMSTGADGGAGGAAGMWGTGGSGG AGAAGIGGGLTGGAGGAGGAGGWLTGTGGAGGSGGYSSTADGGVGGAGGAGGLWGGGGIGGTGGFGALNG AAGGVGGAGGLLGGLVGAGGGDGGAGGYGLTGAGGAGGAGGNSGLLSGPGGSGGTGGAGAVADGGVGGAG GSAGLLFGSGGIGGDGGFGSNTGGAGGAGGNAGLLFSSAGAGGFGGFGVANGGGSGGAGGNAGLLGCGGA GGAGGLGIAGTGGSGGAGGTGGVLLGTGGAGGSGAESLGVGDSGGAGGMGGNAVLIGTGGNGGNGGVGAG TGTRGAGGSGGLLLGQDGSDGLP*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_1391 | - | - | 100% (864) | PE-PGRS family protein, PE_PGRS9 |
M. marinum M | MMAR_4398 | - | 0.0 | 64.62% (927) | PE-PGRS family protein, PE_PGRS9_3 |
M. marinum M | MMAR_4399 | - | 0.0 | 65.84% (925) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0767 | PE_PGRS9 | 0.0 | 62.34% (879) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-153 | 46.57% (773) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv0746 | PE_PGRS9 | 0.0 | 63.94% (832) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 7e-11 | 40.23% (87) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 4e-51 | 33.13% (495) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_4827 | - | 5e-24 | 43.64% (165) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-119 | 38.66% (895) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 1e-39 | 42.24% (303) | PUTATIVE - |
M. ulcerans Agy99 | MUL_2485 | - | 0.0 | 95.16% (744) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-148 | 46.23% (796) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_1391|M.marinum_M -------------------------------------------------- MUL_2485|M.ulcerans_Agy99 -------------------------------------------------- Mb0767|M.bovis_AF2122/97 -------------------------------------------------- Rv0746|M.tuberculosis_H37Rv -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1391|M.marinum_M ------------------MTLVDVVPGMVQAAANDLAGLNTTLNAANAAA MUL_2485|M.ulcerans_Agy99 ------------------MTLVDVVPGMVQAAANDLAGLNTTLNAANAAA Mb0767|M.bovis_AF2122/97 ------------------MSFVLAMPEVLGSAATDLAALGSVLGAADAAA Rv0746|M.tuberculosis_H37Rv ------------------MSFVLAMPEVLGSAATDLAALGSVLGAADAAA Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------MSIIDFILNLFRDPVEAASYVADPEAALANAG MAV_4827|M.avium_104 ------------------MNIVLGVSMAPSSIQMVVLEGEYADGATVEED MMAR_1391|M.marinum_M ATQITTVVAAAQDEVSAAIAAQFSGHGLAYQQLSTQVGVFSDQFVAALSA MUL_2485|M.ulcerans_Agy99 ATQITTVVAAAQDEVSAAIAAQFSGHGLAYQQLSTQVGVFSDQFVAALSA Mb0767|M.bovis_AF2122/97 AATTTGIVAAVQDEVSAAIAALFSAHGRAYQVASAQAAAVHAQFVEALSA Rv0746|M.tuberculosis_H37Rv AATTTGIVAAAQDEVSAAIAALFSAHGRAYQVASAQAAAVHAQFVEALSA Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 LSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAA MAV_4827|M.avium_104 AIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEA MMAR_1391|M.marinum_M SAS----------------------------------------------- MUL_2485|M.ulcerans_Agy99 SAS----------------------------------------------- Mb0767|M.bovis_AF2122/97 GAG----------------------------------------------- Rv0746|M.tuberculosis_H37Rv GAG----------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 QPD----------------------------------------------- MAV_4827|M.avium_104 AALR---------------------------------------------- MMAR_1391|M.marinum_M ---------------------GYSAAEAANTGPLQ--------QLLTLIN MUL_2485|M.ulcerans_Agy99 ---------------------GYSAAEAANTGPLQ--------QLLTLIN Mb0767|M.bovis_AF2122/97 ---------------------AYASAEAAGAAVLANPAQSVQQDLLAAVN Rv0746|M.tuberculosis_H37Rv ---------------------AYASAEAAGAAVLANPAQSVQQDLLAAVN Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------------GPSILSPSLLSPRDNDFLSHNDTDFA MAV_4827|M.avium_104 --------------------------------------DALAARRIDNVM MMAR_1391|M.marinum_M APLLAATGRPLIGNGANGAPG-----TGANGGDGGWLLGDGGIGGSGTPG MUL_2485|M.ulcerans_Agy99 APLLAATGRPLIGNGANGAPG-----TGANGGDGGWLLGDGGIGGSGTPG Mb0767|M.bovis_AF2122/97 AQSVALTGRPLIGNGANGAPG-----TGANGAPGGWLLGNGGAGGSAAAG Rv0746|M.tuberculosis_H37Rv AQSVALTGRPLIGNGANGAPG-----TGANGAPGGWLLGNGGAGGSAAAG Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG TH_3810|M.thermoresistible__bu ------------------------------------------------VD MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVA MAV_4827|M.avium_104 LVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVY MMAR_1391|M.marinum_M TVANPTGGIGGAGGAAGLLGSGGAGGA---GGSSAFGDGGAGGVGGAGGW MUL_2485|M.ulcerans_Agy99 TVANPTGGVGGVGGAAGLLGSGGAGGA---GGSSAFGDGGAGGVG---GW Mb0767|M.bovis_AF2122/97 -----SGLPGGAGGAAGLFGTGGAGGA---GGSSTVGDGGAGGAGGSGGW Rv0746|M.tuberculosis_H37Rv -----SGLPGGAGGAAGLFGTGGAGGA---GGSSTVGDGEAGGAGGSGGW Mflv_5091|M.gilvum_PYR-GCK G----NGGNGGNAGAFALFGNGGNGGN---GGVGVVGATGAVG--APGVA Mvan_1264|M.vanbaalenii_PYR-1 G----DGGNGGDAGLFSLFGRGGNGGN---GGVGIAGATGAVG--APGVA MSMEG_0868|M.smegmatis_MC2_155 L----DGGNGGSGG--LLMGIGGAGGA---GGVGADGTSAHVDGGTGGTG TH_3810|M.thermoresistible__bu G----DGGSGGRTGLFSKLSRGGDGGD---GGLG-------------GNG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VGGSNSGPIASGQGSTAVNGDVRDSNI---INADHGSNVGVDQSQTRVGG MAV_4827|M.avium_104 KQQIRAESYGDAAGQLSAMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQ MMAR_1391|M.marinum_M LSGNAGAGGAGGPGLFGFNGGAGGAGGAGGLLGAGGLGGAGG-------- MUL_2485|M.ulcerans_Agy99 LSGNAGAGGAGGPGLFGFNG---GAGGAGGLLGAGGLGGAGG-------- Mb0767|M.bovis_AF2122/97 LLGTGGVGGVGGLGAG--AGGAGGVGGAGGLLGAGGHGGAGG-------- Rv0746|M.tuberculosis_H37Rv LLGTGGVGGVGGLGAG--AGGAGGVGGAGGLLGAGGHGGAGG-------- Mflv_5091|M.gilvum_PYR-GCK GATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-------- Mvan_1264|M.vanbaalenii_PYR-1 GATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-------- MSMEG_0868|M.smegmatis_MC2_155 GTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVL TH_3810|M.thermoresistible__bu GHGGGTGIIS--------------------LLSLAGNGGNGG-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 DYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTN-------- MAV_4827|M.avium_104 TTTFLDVSVAEEPETALARGAALAAANAPLFASSTAALAYAQ-------- MMAR_1391|M.marinum_M -------YGPGGVGGTGGAGGAGGLLAGLVGAGGGHGGTGGFGAGGTGGD MUL_2485|M.ulcerans_Agy99 -------YGPGGVGGTGGAGGAGGLLAGLVGAGGGHGGTGGFGAGGTGGD Mb0767|M.bovis_AF2122/97 -------LG-AVTGGVGGAGGAGGLLA----------------------- Rv0746|M.tuberculosis_H37Rv -------LG-AVTGGVGGTGGAGGLLA----------------------- Mflv_5091|M.gilvum_PYR-GCK ------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG--------- Mvan_1264|M.vanbaalenii_PYR-1 ------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG--------- MSMEG_0868|M.smegmatis_MC2_155 IAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGAN TH_3810|M.thermoresistible__bu -------NGYRTTDNNALDGGHGG-------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------IGSGNTTNTEIGSHNQANIG----------------------- MAV_4827|M.avium_104 ------DPGTGAVDQYSLPDYLYVPVDP---------------------- MMAR_1391|M.marinum_M GGAGGNAGLFGGPGGAGGTGGVGTGGDGGNGGAG---------------- MUL_2485|M.ulcerans_Agy99 GGAGGNAGLFGGPGGAGGTGGVGTGGDGGNGGAG---------------- Mb0767|M.bovis_AF2122/97 -------GLLAGPGGAGGTGGRGFLNDGGVGGAG---------------- Rv0746|M.tuberculosis_H37Rv -------GLLAGPGGAGGTGGRGFLNNGGVGGAG---------------- Mflv_5091|M.gilvum_PYR-GCK -------AVGAAGAAG------TVGTAGATGGTG---------------T Mvan_1264|M.vanbaalenii_PYR-1 -------AIGTAGVAG------AAGTAGATGGTG---------------V MSMEG_0868|M.smegmatis_MC2_155 GGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTAT TH_3810|M.thermoresistible__bu -------------------------------------------------N MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------TSTSAGGSAAVG---------------- MAV_4827|M.avium_104 ---------------------EPGDDELAYSAVG---------------- MMAR_1391|M.marinum_M GNAGALFGTGGAGGAGGSG-----------VAGAGGVGGAGGNAGLLFSA MUL_2485|M.ulcerans_Agy99 GNAGALFGTGGAGGAGGSG-----------VAGAGGVGGAGGNAGLLFSA Mb0767|M.bovis_AF2122/97 GNAGLLFGAGGTGGSGGAG-----------LGGDGGAGGAGGNAGVLFGN Rv0746|M.tuberculosis_H37Rv GNAGLLFGAGGTGGSGGAG-----------LGGDGGAGGAGGNTGVLFGN Mflv_5091|M.gilvum_PYR-GCK GANGGAGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGA Mvan_1264|M.vanbaalenii_PYR-1 GGNGGAGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGV MSMEG_0868|M.smegmatis_MC2_155 GGDGGHSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGA TH_3810|M.thermoresistible__bu GGNVGFFSLFNLGG--------------------AGGWGGSGVDG----- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -GNAGLAGNAGLAGNAGLAG----------NAGLAGNAGLAGNAGLAGNA MAV_4827|M.avium_104 -EEDAESPTVVIEKLFLPE-------------DSEPRRRPVLLVGSGLAV MMAR_1391|M.marinum_M GGVGGAGGYGSSDGGAGGAGGNGGLLYSNGGVGGTGG------------- MUL_2485|M.ulcerans_Agy99 GGVGGAGGYGSSDGGAGGAGGNGGLLYSNGGVGGTGG------------- Mb0767|M.bovis_AF2122/97 AGSGGTGGFGDTDGGAGGAGGDAGWLGS-GGVGGAGG------------- Rv0746|M.tuberculosis_H37Rv AGSGGTGGFGDTDGGAGGAGGDAGWLGS-GGVGGAGG------------- Mflv_5091|M.gilvum_PYR-GCK GGVGGQ--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG---- Mvan_1264|M.vanbaalenii_PYR-1 GGIGGQ--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG---- MSMEG_0868|M.smegmatis_MC2_155 GGMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTG TH_3810|M.thermoresistible__bu ----------------VDVVGGNP-------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG------------- MAV_4827|M.avium_104 VGISAVLALEIALAIGIRTTGTVALQPTPNQHLIVPT------------- MMAR_1391|M.marinum_M -----------YGAAAAGGAGGAGGRAGLAIG------------------ MUL_2485|M.ulcerans_Agy99 -----------YGAAAAGGVGGAGGRAGLAIG------------------ Mb0767|M.bovis_AF2122/97 -----------FGETGDGGVGGAGGKAGLLIG------------------ Rv0746|M.tuberculosis_H37Rv -----------FGETGDGGVGGAGGKAGLLIG------------------ Mflv_5091|M.gilvum_PYR-GCK ---------LQGGKGGDGGAGGKGGDADSMGS------------------ Mvan_1264|M.vanbaalenii_PYR-1 ---------LQGGQGGDGGTGGTGGDATSMGE------------------ MSMEG_0868|M.smegmatis_MC2_155 GKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGA TH_3810|M.thermoresistible__bu ----------------DGGTPG---------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------LAGNAGLAGNAGLAGNAGLAGN------------------ MAV_4827|M.avium_104 -----------EQAPAPPPVQASAPQPKISVP------------------ MMAR_1391|M.marinum_M ---GGGAGGAGGEGATTGGDGGAGGTG----------------------- MUL_2485|M.ulcerans_Agy99 ---GGGAGGAGGEGATTGGDGGAGGTG----------------------- Mb0767|M.bovis_AF2122/97 ---NGGAGGAG--------------------------------------- Rv0746|M.tuberculosis_H37Rv ---NGGAGGAGGQGAVTGGTGGAGGDG----------------------- Mflv_5091|M.gilvum_PYR-GCK AGATGGKGGNGGNGGRGGLFG---------------KGGNAGNGAD---- Mvan_1264|M.vanbaalenii_PYR-1 AGATGGKGGNGGNGGRGSLFG---------------RGGNAGNGGN---- MSMEG_0868|M.smegmatis_MC2_155 ASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQ TH_3810|M.thermoresistible__bu --AHGESHTPGVYTDRQ--------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----AGLAGNAGLAGNAGLAG----------------------------- MAV_4827|M.avium_104 ----EPVAAPKPLSPPVAAPLP---------------------------- MMAR_1391|M.marinum_M ----------------VLIGNGGNAGVGGTGPAAGATGVGGTSG------ MUL_2485|M.ulcerans_Agy99 ----------------VLIGNGGNAGVGGTGPAAGATGVGGTSG------ Mb0767|M.bovis_AF2122/97 ----------------VLIGNGGNAGIGGTGPTAGDTGAGGISG------ Rv0746|M.tuberculosis_H37Rv ----------------VLIGNGGNAGIGGTGPTAGDTGAGGISG------ Mflv_5091|M.gilvum_PYR-GCK ------------------GGTGGAGGAGGTGG-TGGAGGTGG-------- Mvan_1264|M.vanbaalenii_PYR-1 ------------------GGTGGNGGNGGTGG-TGGNGGTGG-------- MSMEG_0868|M.smegmatis_MC2_155 AYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKAN TH_3810|M.thermoresistible__bu ----------------------GEDGEDGTGTGIGGRGGNGG-------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------NAGLAGNAGLAGNAAVAGNAAVAGNAA------ MAV_4827|M.avium_104 -----------------------AAPPPAAPPLPEAPPIPAAPP------ MMAR_1391|M.marinum_M --------LLLGLDGFNAPASTSPLHTFQQQALGAVNAPVQTLTGRPLIG MUL_2485|M.ulcerans_Agy99 --------LLLGLDGFNAPASTSPLHTFQQQALGAVNAPVQTLTGRPLIG Mb0767|M.bovis_AF2122/97 --------LLLGADGFNAPASASPLHTLKQQALAAINAPTQTLTGRPLIG Rv0746|M.tuberculosis_H37Rv --------LLLGADGFNTPASASPLHTLKQQALAAINAPTQTLTGRPLIG Mflv_5091|M.gilvum_PYR-GCK ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 ---------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGH TH_3810|M.thermoresistible__bu --------SSSGTHPMAEDG--------EHVKALDGRPGLD---GGNGSH MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------VAGNAAVGGVLNTGVSGAIGGSSHVGG--AINESLGGSGSV MAV_4827|M.avium_104 --------VVPVPVVVPPVPVPVPVRIPVPDPVSPPQLLAPPRLSVPQPV MMAR_1391|M.marinum_M NGTPGAAGSGAAGTAGGWVF------GDGGAGGSGAMS----------TG MUL_2485|M.ulcerans_Agy99 NGTPGAAGSGAAGTAGGWVF------GDGGADGSGAMS----------TG Mb0767|M.bovis_AF2122/97 NGTPGAVGSGATGAPGGWLL------GDGGAGGSGAAG----------SG Rv0746|M.tuberculosis_H37Rv NGTPGAVGSGATGAPGGWLL------GDGGAGGSGAAG----------SG Mflv_5091|M.gilvum_PYR-GCK GGTGGKGGTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTG Mvan_1264|M.vanbaalenii_PYR-1 GGTGGKGGTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTG MSMEG_0868|M.smegmatis_MC2_155 GGDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAG TH_3810|M.thermoresistible__bu GGNGGHGGRGGFLGIGGSG-------GWGGHGGNGGD-----------TD MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GGSTAVGGGAHTGVGGGVSTG----VGVGSHVGGG------------ISE MAV_4827|M.avium_104 QPPVRVPQPPSPPQVGGTVPQ-----SPPQHQTPPGEG---------TPP MMAR_1391|M.marinum_M ADGGAGGAAG------------MWGTGGSGGAG----------------- MUL_2485|M.ulcerans_Agy99 ADGGAGGAAG------------MWGTGGSGGAG----------------- Mb0767|M.bovis_AF2122/97 APGGAGGAAG------------LWGTGGAG-------------------- Rv0746|M.tuberculosis_H37Rv APGGAGGAAG------------LWGTGGAGGAGG---------------- Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG--- Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG--- MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEAL TH_3810|M.thermoresistible__bu ADGGNGGDG---------------GNGGSAG------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SLGGSGSVG---------------GSTAVGG------------------- MAV_4827|M.avium_104 KPDGPGNYGG--------------GHVPTPG------------------- MMAR_1391|M.marinum_M -------------AAGIGGGLTGGAGGAGGAGGWLT--GTGGAGGSGGYS MUL_2485|M.ulcerans_Agy99 -------------PAGIGGGLTGGAGGAGGAG---------------GYS Mb0767|M.bovis_AF2122/97 ---------------GAGGWLLG-DGGAGGIGG----------------A Rv0746|M.tuberculosis_H37Rv ---SSAGGGGAGGAGGAGGWLLG-DGGAGGIGG----------------A Mflv_5091|M.gilvum_PYR-GCK --------------TGGTGGQGG-LGGGGGTG------------------ Mvan_1264|M.vanbaalenii_PYR-1 --------------TGGTGGQGG-LGGVGGTG------------------ MSMEG_0868|M.smegmatis_MC2_155 IRATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQAS TH_3810|M.thermoresistible__bu --------------RGGTGGLRGVFGINGGNG------------------ MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------GAHTGVGGGVSTGVGVG------------------ MAV_4827|M.avium_104 --------------AGGSGGSGGGHVPTPGAG------------------ MMAR_1391|M.marinum_M STADGGVGGAGGAGGLWGGGGIGGTGGFG--------ALNG--AAGGVGG MUL_2485|M.ulcerans_Agy99 STADGGVGGAGGAGGLWGGGGIGGTGGFG--------ALNG--AAGGVGG Mb0767|M.bovis_AF2122/97 STVLGGTGGGGGVGGLWGAGGAGGAGGTG--------LVGGDGGAGGAGG Rv0746|M.tuberculosis_H37Rv STVLGGTGGGGGVGGLWGAGGAGGAGGTG--------LVGGDGGAGGAGG Mflv_5091|M.gilvum_PYR-GCK -----GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGG Mvan_1264|M.vanbaalenii_PYR-1 -----GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGG MSMEG_0868|M.smegmatis_MC2_155 GTATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGG TH_3810|M.thermoresistible__bu ------RAGLGGRGXXXXGGGVGAAVRSG---------------NGVFSG MLBr_01183|M.leprae_Br4923 ------MPLFLNAEPQALTAAANTLEGLS---------------AATVAS MAB_4284c|M.abscessus_ATCC_199 -----SHVGGGISESLGGSGSVGGSTAVG---------------GGAHTG MAV_4827|M.avium_104 -------GSGGSGGGHVPTPGTGGPGGTG----------------GSGGG . . . . . MMAR_1391|M.marinum_M AGGLLGGLVGAGGGDGGAGGYGLTGAGGAGG------------------A MUL_2485|M.ulcerans_Agy99 AGGLLGGLVGAGGGDGGAGGYGLTGAGGAGG------------------A Mb0767|M.bovis_AF2122/97 TGGLLAGLIGAGGGHGGTGGLNTNGDGGVGG------------------A Rv0746|M.tuberculosis_H37Rv TGGLLAGLIGAGGGHGGTGGLSTNGDGGVGG------------------A Mflv_5091|M.gilvum_PYR-GCK LGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----G Mvan_1264|M.vanbaalenii_PYR-1 LGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----G MSMEG_0868|M.smegmatis_MC2_155 LGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQ TH_3810|M.thermoresistible__bu GGGTPSAGFGVPTTIQFPAGSCTSRAVSREG------------------- MLBr_01183|M.leprae_Br4923 NAAAAQLTTEIAPPAADDVSILLAHFFSGHG------------------- MAB_4284c|M.abscessus_ATCC_199 VGGGVNTGVGVGSHVGGGISESLGGSGSVGG------------------S MAV_4827|M.avium_104 HVPTPGAGTPGGSGGGHLPFPGAGSTPGGSG------------------- . * MMAR_1391|M.marinum_M GGNSGLLSGPGGSGGTGGAG-AVADGGVGGAG--------GSAGLLFGSG MUL_2485|M.ulcerans_Agy99 GGNSGLLSGPGGSGGTGGAG-AVADGAVGGAG--------GSAGLLFGSG Mb0767|M.bovis_AF2122/97 GGNAGMLAGPGGAGGAGGDGENLDTGGDGGAG--------GSAGLLFGSG Rv0746|M.tuberculosis_H37Rv GGNAGMLAGPGGAGGAGGDGENLDTGGDGGAG--------GSAGLLFGSG Mflv_5091|M.gilvum_PYR-GCK SGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAA Mvan_1264|M.vanbaalenii_PYR-1 SGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGAS MSMEG_0868|M.smegmatis_MC2_155 SGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNT TH_3810|M.thermoresistible__bu -----IMPSSRAASARAG---------------------------AACAS MLBr_01183|M.leprae_Br4923 ----RQYQAHASQGATNHQD--------------------LIQSLLTSSS MAB_4284c|M.abscessus_ATCC_199 TAVGGGAHTSAINDALGGSGSVGGSTAVG-----------GGAHTSAINE MAV_4827|M.avium_104 ---GGHLPTPGAGTPGGGLGGFG-----------------GGHAPAPGGG MMAR_1391|M.marinum_M GIGGDGGFGSNTGGAGGAGGNAGLLFSSAGAGGFGGFGVANGGGSGGAGG MUL_2485|M.ulcerans_Agy99 RIGGDGGFGSNTG------------------------------------- Mb0767|M.bovis_AF2122/97 GAGGAGGFG-FLGGDGGAGGNAGLLLSSGGAGGFGGFG--TAGGVGGAGG Rv0746|M.tuberculosis_H37Rv GAGGAGGFG-FLGGDGGAGGNAGLLLSSGGAGGFGGFG--TAGGVGGAGG Mflv_5091|M.gilvum_PYR-GCK GKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGS Mvan_1264|M.vanbaalenii_PYR-1 GAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGS MSMEG_0868|M.smegmatis_MC2_155 ATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGG TH_3810|M.thermoresistible__bu STSRSRRSFCCSRA------------------------------------ MLBr_01183|M.leprae_Br4923 AYAGTETANHDSL------------------------------------- MAB_4284c|M.abscessus_ATCC_199 SMNSSINASHSSSMNESFG------------------------------- MAV_4827|M.avium_104 LGGGGGHAPAPGGGLGGFG------------------------------- MMAR_1391|M.marinum_M NAGLLGCGGAGGAGGLGIAGTGGSGGAGGTGGVLLGTGGAGGSGAESLGV MUL_2485|M.ulcerans_Agy99 -------------------------------------------------- Mb0767|M.bovis_AF2122/97 NAGWLGFGGAGGIGGIGGNANGGAGGNGGTGGQLWGSGGAGGEGGAALSV Rv0746|M.tuberculosis_H37Rv NAGWLGFGGAG--------------------------------------- Mflv_5091|M.gilvum_PYR-GCK QGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG Mvan_1264|M.vanbaalenii_PYR-1 QGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG MSMEG_0868|M.smegmatis_MC2_155 KGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MMAR_1391|M.marinum_M GDSGGAGGMGGNAVLIGTGGNGGNGGVGAG--------TGTRGAGGSGGL MUL_2485|M.ulcerans_Agy99 ------------------------------------------GAGGSGGL Mb0767|M.bovis_AF2122/97 GDTGGAGGVGGSAGLIGTGGNGGNGGTGAN--------AGSPGTGGAGGL Rv0746|M.tuberculosis_H37Rv -------GVGGSAGLIGTGGNGGNGGTGAN--------AGSPGTGGAGGL Mflv_5091|M.gilvum_PYR-GCK -----------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGS Mvan_1264|M.vanbaalenii_PYR-1 -----------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGS MSMEG_0868|M.smegmatis_MC2_155 NTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGT TH_3810|M.thermoresistible__bu -------------------------------------------------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ------------------SSMGSHGAAGTG--------FEAQGHAQGHAS MAV_4827|M.avium_104 ---------------------------------------GGHSGGGLGGL MMAR_1391|M.marinum_M LLGQDGSDGLP----------------------- MUL_2485|M.ulcerans_Agy99 LLGQDGSDGLP----------------------- Mb0767|M.bovis_AF2122/97 LLGQNGLNGLP----------------------- Rv0746|M.tuberculosis_H37Rv LLGQNGLNGLP----------------------- Mflv_5091|M.gilvum_PYR-GCK GAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD Mvan_1264|M.vanbaalenii_PYR-1 GTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD- MSMEG_0868|M.smegmatis_MC2_155 TAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP TH_3810|M.thermoresistible__bu ---------------------------------- MLBr_01183|M.leprae_Br4923 ---------------------------------- MAB_4284c|M.abscessus_ATCC_199 ETAHTTLPGAEHH--------------------- MAV_4827|M.avium_104 GGGHK-----------------------------